484
56
9
155
11
Cat. No. | Product Name | ||
---|---|---|---|
L1800 | 抗感染化合物库 | 2938 compounds | |
2938 种具有抗感染活性的化合物的特有集合,包括抗细菌、抗真菌、抗巨细胞病毒、抗HIV、抗SARS、抗流感等活性; | |||
L9700 | 内质网应激化合物库 | 193 compounds | |
193 个内质网应激相关的化合物集合,可用于高通量和高内涵筛选; | |||
L3400 | 临床期小分子药物库 | 3404 compounds | |
3404 个临床期化合物集合,可用于高通量筛选和高内涵筛选; | |||
L2910 | 抗氧化化合物库 | 1314 compounds | |
氧化应激(Oxidative Stress,OS)是指体内氧化与抗氧化作用失衡的一种状态。氧化应激导致活性氧(ROS)大量积累,氧化程度超出抗氧化物的清除能力,从而引起氧化损伤,氧化应激损伤是许多疾病发生的基础,不同程度的氧化应激造成的细胞效应与心脑血管疾病、神经退行性病变、炎症和肿瘤密切相关。抗氧化剂是一类能够对抗氧化应激,降低氧化损伤的一类化合物。 TargetMol 抗氧化化合物库是1314 种对氧化应激具有抑制作用的小分子特有集合,是研究氧化应激的有用工具,可以用于高通量筛选和高内涵筛选。 | |||
L9420 | 外泌体相关化合物库 | 76 compounds | |
76 种外泌体相关的化合物,可以用于高通量和高内涵筛选; | |||
L9820 | β-内酰胺类化合物库 | 97 compounds | |
97 种β-内酰胺类化合物的集合,可以用于高通量和高内涵筛选; | |||
L1720 | 核苷类化合物库 | 334 compounds | |
334 种核苷类化合物,包括核苷酸、核苷酸类似物及衍生物等,适用于抗病毒、抗肿瘤、抗真菌、抗抑郁等药物的研发; | |||
L6610 | 抗感染天然产物库 | 1060 compounds | |
1060 个抗感染相关的天然产物集合,是药物开发、药理研究的有效工具; | |||
L7600 | 趋化因子抑制剂库 | 59 compounds | |
59 种趋化因子或其受体抑制剂的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1305 |
Ceftazidime
GR20263,头孢他啶 |
Antibacterial; Antibiotic | Microbiology/Virology |
Ceftazidime (GR20263) 是可静脉内或肌肉给药的第头孢菌素。它对革兰氏阳性和革兰氏阴性需氧细菌有体外活性。它对肠杆菌科特别有效,对大多数 β-内酰胺酶具有抗水解作用。 | |||
T1154 |
Rifaximin
|
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Rifaximin 是一种胃肠道选择性抗生素,与细菌 DNA 依赖性 RNA 聚合酶的 β 亚基结合,抑制细菌 RNA 合成。与革兰氏阴性菌(MIC:8-50 毫克/毫升)相比,它对革兰氏阳性菌株(MIC:0.03-5 毫克/毫升)的敏感性更高。 | |||
T11539 |
HCV-IN-29
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
HCV-IN-29 是一种丙型肝炎病毒抑制剂。 | |||
T37514 |
Hydroxy Dimetridazole
|
Drug Metabolite | Metabolism |
Hydroxy Dimetridazole 是Dimetridazol 的羟基化代谢产物。Dimetridazol 是一种硝基咪唑类药物,可用于对抗原生动物感染。 | |||
T0234 |
Methicillin sodium salt
Methicillin sodium,Meticillin sodium,甲氧西林钠 |
Antibacterial; Antibiotic | Microbiology/Virology |
Methicillin sodium salt 是β-内酰胺抗生素,抑制参与肽聚糖合成的青霉素结合蛋白。 | |||
T8337 |
Nequinate
|
Xanthine Oxidase; Parasite | Metabolism; Microbiology/Virology |
Nequinate 是一种喹啉化合物,是一种抗球虫剂,可预防球虫病。它抑制黄嘌呤氧化还原酶活性。 | |||
T8722 |
iKIX1
|
Antifungal | Microbiology/Virology |
iKIX1 是一种 Pdr1 依赖性基因激活。 它在体外和在播散性和泌尿道光滑念珠菌感染的动物模型中使耐药的光滑念珠菌对唑类抗真菌剂重新敏感。它可研究多药耐药性和光滑念珠菌感染。 | |||
T20525 |
Chloramphenicol palmitate
|
Antibacterial; Antibiotic | Microbiology/Virology |
Chloramphenicol palmitate 是一种广谱抗生素,对革兰氏阳性和革兰氏阴性细菌具有活性。 Chloramphenicol palmitate 可用于在含有氯霉素抗性基因的转化细胞中作为细菌选择剂的研究。 | |||
T11541 |
HCV-IN-30
|
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
HCV-IN-30 是 HCV NS5A 复制复合物的抑制剂(基因型 1a 和 1b 复制子的 IC50 = 901 和 102 nM)。 | |||
T5477 |
ELQ-300
|
Parasite | Microbiology/Virology |
ELQ-300 是一种有口服生物活性的抗疟疾剂,可作为细胞色素 bc1 复合物的还原位点的抑制剂 | |||
T1444 |
Lomefloxacin
洛美沙星,SC47111A |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Lomefloxacin (SC47111A) 是一种广谱喹诺酮类抗生素,具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。 | |||
T4985 |
Neticonazole Hydrochloride
|
Antifungal | Microbiology/Virology |
Neticonazole hydrochloride 是一种咪唑衍生物,具有抗感染和抗癌作用。它也是一种长效抗真菌剂。 | |||
T60050 |
ANT3310
|
Antibacterial | Microbiology/Virology |
ANT3310 是一种广谱共价丝氨酸 β-内酰胺酶抑制剂,对 AmpC、CTX-M-15、TEM-1、OXA-48、OXA-23 和 KPC-2 的 IC50 范围为 1 nM 至 175 nM。 ANT3310 可用于细菌感染研究。 | |||
T1883 |
Des(benzylpyridyl) Atazanavi
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Des(benzylpyridyl) Atazanavi 是 Atazanavir 的 N-脱烷基代谢物 (M1),一种 HIV 蛋白酶抑制剂。 | |||
T10797 |
Chlormidazole hydrochloride
Clomidazole hydrochloride |
Antifungal | Microbiology/Virology |
Chlormidazole hydrochloride (Clomidazole hydrochloride) 是一种抗真菌剂,抑制多种真菌和部分革兰氏阳性球菌,可治疗指甲和皮肤的真菌和细菌感染。 | |||
T8371 |
ML188
|
Virus Protease; SARS-CoV | Microbiology/Virology |
ML188是一种选择性非共价 SARS-CoV3CLpro 抑制剂,具有抗病毒活性,IC50为 1.5 μM。 | |||
T0830 |
Bithionol
硫双二氯酚,Actamer,硫氯酚 |
cAMP; Parasite | GPCR/G Protein; Microbiology/Virology |
Bithionol (Actamer) 是一种抗寄生虫药物,对若干癌细胞有抑制作用。 | |||
T0748 |
Sulfameter
5-Methoxysulfadiazine,Sulfametoxydiazine,磺胺对甲氧嘧啶 |
DHFR; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Sulfameter (Sulfametoxydiazine) 是一种长效磺胺类抗生素,具有抗菌活性。它可研究尿路感染和麻风病。 | |||
T0395 |
Pyrantel tartrate
Banminth,酒石酸噻吩嘧啶 |
Antibiotic; Parasite | Microbiology/Virology |
Pyrantel tartrate (Banminth) 是一种四氢嘧啶类广谱牲畜驱虫剂,是烟碱乙酰胆碱受体激动剂。它能引起寄生虫的痉挛性肌肉麻痹。它可研究胃肠道线虫感染。 | |||
T19862 |
Voxilaprevir
维昔普维,伏西瑞韦 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Voxilaprevir 是丙型肝炎病毒非结构蛋白 3/4A 蛋白酶的抑制剂,具有抗病毒活性。它抑制基因型 1b 和 3a 野生型 NS3 蛋白酶的 Ki 值分别为 0.038 nM 和 0.066 nM。 | |||
T0328 |
Hexetidine
NSC-17764,海克替啶 |
Antibacterial; Antifungal | Microbiology/Virology |
Hexetidine (NSC-17764) 是一种口服活性的抗菌抗真菌试剂,可用于口腔感染的相关研究。 | |||
T1647 |
Ronidazole
洛硝哒唑,Ronidazol,罗硝唑,Ridzol |
Antibacterial; Antibiotic; Parasite | Microbiology/Virology |
Ronidazole (Ronidazol) 是一种口服有效的抗原虫和抗菌试剂。它在猫模型中对胎儿三毛滴虫有效,还可研究组织口癣和猪痢疾。 | |||
T6582 |
Mezlocillin Sodium
美洛西林钠,Baycipen |
Antibacterial; Antibiotic | Microbiology/Virology |
Mezlocillin Sodium (Baycipen) 是一种青霉素 β-内酰胺类抗生素,用于治疗由易感染微生物引起的细菌感染。 | |||
T18928 |
Brilliant Black BN
亮黑1,E 151 |
Others; Virus Protease | Microbiology/Virology; Others |
Brilliant Black BN (E 151) 是一种偶氮染料和一种食品着色剂。它抑制 EV71 与其细胞脱壳因子亲环蛋白 A 之间的相互作用,是一种很有前途的抗 EV71 感染的抗病毒药物。 | |||
T1070 |
Cefmetazole sodium
头孢美唑钠,Sodium cefmetazole |
Antibacterial; Antibiotic | Microbiology/Virology |
Cefmetazole sodium (Sodium cefmetazole) 是具有广谱抗菌活性的半合成头孢霉素抗生素。它通过与青霉素结合蛋白结合,阻止肽聚糖的交联,导致细胞壁完整性的丧失。它可研究妇科、腹腔内、尿道、呼吸道和皮肤和软组织感染。 | |||
T2411 |
Luliconazole
NND 502,卢立康唑 |
Antibiotic; Antifungal | Microbiology/Virology |
Luliconazole (NND 502) 是一种咪唑类抗生素,具有广谱抗真菌活性。它可研究皮肤感染。 | |||
T1259 |
Pyrantel pamoate
双羟萘酸噻嘧啶,Pyrantel embonate |
Others; Antibiotic; Parasite | Microbiology/Virology; Others |
Pyrantel pamoate (Pyrantel embonate) 是一种四氢嘧啶光谱驱虫剂,是烟碱乙酰胆碱受体激动剂。它可引起寄生虫的痉挛性肌肉麻痹。它可研究胃肠道线虫感染。 | |||
T37340 |
N4-Acetylsulfamethoxazole
N-acetyl Sulfamethoxazole,醋磺胺甲噁唑 |
Others | Others |
N4-Acetylsulfamethoxazole 是磺胺甲恶唑的一种代谢物。Sulfamethoxazole 属于磺胺类抗菌素,可用于细菌感染。 | |||
T8139 |
Sulfamethoxazole sodium
新诺明钠,Ro 4-2130 sodium,磺胺甲恶唑钠 |
Others; Antibacterial; Antibiotic | Microbiology/Virology; Others |
Sulfamethoxazole sodium (Ro 4-2130 sodium) 是一种磺胺类抗菌素。它常用于各种尿道病原体的研究,与 Trimethoprim 联用,可用于尿路感染的研究。 | |||
T1557 |
Acetylspiramycin
Spiramycin II,Foromacidin B,乙酰螺旋霉素,ASPM,Spiramycin B |
ribosome; Antibacterial; Antibiotic | Microbiology/Virology |
Acetylspiramycin (Spiramycin B) 是口服大环内酯抗生素,由多种链霉菌产生,是螺旋霉素的乙酰化衍生物 。它是对革兰氏阳性菌有效的抗菌试剂。它也是一种抗原虫剂,有效抵抗寄生虫感染。 | |||
T7766 |
Remdesivir
瑞德西韦,GS-5734 |
SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Remdesivir (GS-5734) 是一种核苷类似物,一种广谱的抗病毒化合物,通过抑制病毒的 RNA 依赖性 RNA 聚合酶发挥活性。Remdesivir 对埃博拉病毒、SARS 病毒、MERS病毒等均有活性,对 COVID-19 有潜在治疗价值。 | |||
T3279 |
Silver sulfadiazine
Silvadene,磺胺嘧啶银,Dermazin,Flamazine |
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Silver sulfadiazine (Dermazin) 是一种磺胺类抗生素,具有抗菌和抗真菌活性。它的通磺胺部分(SD-SDZ) 对细菌生长有双重抑制作用,可阻止细菌叶酸吸收以及 DNA 合成。它释放的银结合并破坏 DNA 结构,阻止细菌 DNA 复制。 | |||
T4382 |
Proguanil hydrochloride
Paludrine hydrochloride,盐酸氯胍,Chlorguanide hydrochloride,Chloroquanil |
Others; Dehydrogenase; DNA/RNA Synthesis; Antifolate; Parasite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; Others |
Proguanil hydrochloride (Chloroquanil) 是一种双胍类抗疟疾剂,在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。 | |||
T1623 |
Lopinavir
ABT-378,洛匹那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Lopinavir (ABT-378) 是一种选择性肽模拟 HIV-1 蛋白酶的高效抑制剂。它通过阻止 HIV-1 的成熟而起作用,从而阻断其感染性。它也是 SARS-CoV 3CLpro 的抑制剂。 | |||
T35427 |
β-Lactamase-IN-2
|
Antibacterial | Microbiology/Virology |
β-Lactamase-IN-2 是 β-内酰胺酶的有效抑制剂。β-Lactamase-IN-2显示出抗菌活性。 | |||
T15394 |
Glyceryl monocaprate
2,3-Dihydroxypropyl decanoate,一癸酸甘油酯,DECANOIN,Monocaprin |
Antibacterial; HSV | Microbiology/Virology |
Glyceryl monocaprate (2,3-Dihydroxypropyl decanoate) 对单纯疱疹病毒具有抑制作用,有潜力治疗唇疱疹。它是一种癸酸的1-单甘油酯,可抗革兰氏阳性细菌感染。 | |||
TQ0095 |
Brincidofovir
CMX001,HDP-CDV |
Others; Antiviral; HSV | Immunology/Inflammation; Microbiology/Virology; Others |
Brincidofovir (HDP-CDV) 是 Cidofovir 的一种具有口服活性的亲脂性形式的前体药物,是一种口服长效的抗病毒药物,有广泛的抗 DNA 病毒活性。 | |||
T6349 |
Sitafloxacin Hydrate
西他沙星水合物,DU-6859a,DU6859a hydrate |
Antibacterial; Antibiotic | Microbiology/Virology |
Sitafloxacin Hydrate (DU-6859a) 是一种口服有效的氟喹诺酮类抗生素,在体外可对抗广泛的革兰氏阳性和阴性细菌有活性。Sitafloxacin 可研究呼吸道感染和尿路感染。 | |||
T1625 |
Lomefloxacin hydrochloride
Lomefloxacin HCl,盐酸洛美沙星,Okacyn,Maxaquin |
Topoisomerase; Antibacterial; Antibiotic | DNA Damage/DNA Repair; Microbiology/Virology |
Lomefloxacin hydrochloride (Okacyn) 是一种广谱喹诺酮类抗生素,具有抗菌活性。它可研究支气管炎、尿路感染、结膜炎、外耳炎和中耳炎。 | |||
T7779 |
Nelfinavir
AG1341,甲磺酸萘非那韦 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Nelfinavir (AG1341) 是一种口服活性的 HIV-1 蛋白酶抑制剂,用于抑制 HIV 感染,是一种广谱抗癌剂。 | |||
T22323 |
Enoxaparin sodium
|
Thrombin | Proteases/Proteasome |
Enoxaparin sodium 是一种低分子量肝素 (LMWH),已获得美国 FDA 批准,可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用,并抑制凝血因子 XIa、IXa、Xa 和 IIa(凝血酶),从而防止血栓形成。 | |||
T7330 |
Nucleozin
[4-(2-氯-4-硝基苯基)-1-哌嗪基](5-甲基-3-苯基-4-异噁唑基)-甲酮 |
Influenza Virus | Microbiology/Virology |
Nucleozin 靶向流感 A 核蛋白,这是一种病毒复制所必需的多功能 RNA 结合蛋白。 | |||
T4991 |
Ertapenem sodium
厄他培南钠,MK-826,L-749345,尔他培南钠 |
Antibacterial; Antibiotic | Microbiology/Virology |
Ertapenem sodium (MK-826) 是碳青霉烯,是一种 β-内酰胺抗生素,具有广谱抗菌活性。 | |||
T1646 |
Famciclovir
泛昔洛韦,BRL 42810 |
DNA/RNA Synthesis; HSV | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Famciclovir (BRL 42810) 是一种单纯疱疹病毒核苷类似物 DNA 聚合酶抑制剂。 | |||
T31482 |
Diloxanide
Diloxanid,RD 3803,RD3803,RD-3803,Diloxanida,二氯尼特 |
Parasite | Microbiology/Virology |
Diloxanide (RD3803) 是一种抗原虫制剂,可研究组织学内阿米巴原虫或者其他原虫感染引起的无症状肠道阿米巴病。它是一种活性的鲁米那抗阿米巴试剂,是由其前药二氯尼特糠酸酯在胃肠道中水解得来的。 | |||
T12732 |
Rezafungin
棘白菌素,SP-3025,CD101,Biafungin |
Others; Antifungal | Microbiology/Virology; Others |
Rezafungin (SP-3025) 是一种长效的广谱棘皮菌素,对念珠菌、曲霉和肺孢子菌具有强效抗真菌活性。 | |||
T25268L |
Coblopasvir dihydrochloride
Coblopasvir dihydrochloride(1312608-46-0 Free base) |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Coblopasvir dihydrochloride 是一种泛基因型非结构蛋白 5A(NS5A)抑制剂。本品可用于慢性丙型肝炎病毒感染的研究。 | |||
T1675 |
Adefovir dipivoxil
Hepsera,GS 0840,阿德福韦酯,Preveon |
Others; HBV; Reverse Transcriptase | Microbiology/Virology; Others |
Adefovir dipivoxil (GS 0840) 是一种腺苷类似物,是核苷逆转录酶抑制剂 Adefovir 的口服前药,具有抗乙型肝炎病毒、疱疹病毒和人类免疫缺陷病毒的活性。 | |||
T7387 |
Ceftaroline fosamil
TAK-599,头孢罗林酯,PPI0903 |
Antibacterial; Antibiotic | Microbiology/Virology |
Ceftaroline fosamil (TAK-599) 是一种头孢菌素衍生物,是抗甲氧西林金黄色葡萄球菌 (MRSA) T-91825 的 N-膦酰基前药,可研究 MRSA 感染。 | |||
T15781 |
LP-935509
|
Serine/threonin kinase; AAK1 (AP2 associated kinase 1) | Cell Cycle/Checkpoint; Metabolism; Neuroscience |
LP-935509 是一种选择性的、具有脑渗透的、小分子的衔接蛋白-2 相关激酶1 (AAK1) ATP 竞争性抑制剂,其 IC50=3.3 nM,Ki=0.9 nM。它是一种 BIKE 的有效抑制剂 (IC50=14 nM) 和中度的 GAK 抑制剂 (IC50=320 nM)。它能够逆转 SNL 手术后的疼痛。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9599 |
3,4,5-Trimethoxybenzaldehyde
|
Anti-infection; Antibacterial | Microbiology/Virology |
3,4,5-Trimethoxybenzaldehyde 是合成各种药物,特别是治疗细菌感染的甲氧苄啶的中间体,它有抗念珠菌功效并抑制粘附和生物膜。 | |||
T9715 |
Aplidine
|
SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性,抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤,晚期癌症及 COVID-19 领域有研究的价值。 | |||
T8716 |
physalin F
酸浆苦味素F,酸浆苦素 F |
Apoptosis | Apoptosis |
Physalin F 是一种分泌型甾体,诱导人外周血单个核细胞凋亡,降低人 T 淋巴细胞 1 型病毒感染后的自发增殖和细胞因子的产生,具有强烈抗炎和免疫调节作用。 | |||
T8205 |
Norwogonin
5,7,8-Trihydroxyflavone,去甲汉黄芩素 |
Virus Protease | Microbiology/Virology |
Norwogonin (5,7,8-Trihydroxyflavone) 是从黄芩中分离出来的,对肠道病毒 71 具有抗病毒活性,IC50为 31.83 μg/ ml。 | |||
T1313 |
Nitrofurantoin
Furadantine,呋喃妥因,Macrodantin,Furadonine |
Antibacterial; Antibiotic | Microbiology/Virology |
Nitrofurantoin (Furadantine) 是一种具有口服活性的广谱内酰胺酶抗菌剂。它是一种抗生素,可研究尿路感染。 | |||
T8689 |
Chloroquine
CQ,氯喹 |
SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Chloroquine 是一种 Toll 样受体抑制剂,可以抑制自噬。Chloroquine 具有抗疟疾和抗炎活性,广泛用于治疗疟疾和类风湿性关节炎。Chloroquine 还具有抗 SARS-CoV-2 (COVID-19) 活性、抗 HIV-1 活性。 | |||
T20712 |
Conessine
Conessinum,Wrightine,地麻素,Roquessine,Neriine,Konessin |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Conessine (Conessinum) 是一种具有抗疟活性的甾体生物碱,是高效选择性H3 受体拮抗剂,对于人、狗、豚鼠和大鼠 H3受体的Ki 分别为 5.4、6.0、5.7 和 25 nM。 | |||
T1079 |
Metronidazole
Flagyl,Metronidazol,甲硝唑,Anagiardil |
Apoptosis; NADPH; Hydrogenase; Antibacterial; Antibiotic; Parasite; Antifection | Apoptosis; Metabolism; Microbiology/Virology |
Metronidazole (Metronidazol) 是一种合成的硝基咪唑衍生物,一种抗生素和抗原虫剂,具有口服活性和血脑屏障渗透性。Metronidazole 可用于治疗或预防厌氧菌引起的系统或局部感染。 | |||
TN2111 |
Prunin
Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷 |
Phosphatase; Anti-infection; Virus Protease | Metabolism; Microbiology/Virology |
Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B,IC50值为 5.5 μM。 | |||
T3950 |
Tridecanoic acid
n-Tridecoic Acid,n-Tridecanoic Acid,十三酸,Tridecylic Acid |
Others; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology; Others |
Tridecanoic acid (Tridecylic Acid) 是一种存在于乳制品中的 13 碳饱和脂肪酸,也是正十六烷厌氧生物降解的产物。 它是磷脂酶 A2 的底物,可作为抗粘剂和抗生物膜剂,用于研究细菌感染。它抑制大肠杆菌的持久性和生物膜形成。 | |||
T1104 |
Paromomycin Sulfate
Aminosidine sulfate,Paromomycin sulfate salt,硫酸巴龙霉素,巴龙霉素硫酸盐 |
Antibacterial; Antibiotic; Parasite | Microbiology/Virology |
Paromomycin Sulfate (Aminosidine sulfate) 是一种广谱氨基糖苷类抗生素 ,是具有杀螨杀菌作用的新霉素衍生物。它通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合,使 mRNA 的翻译提前终止,并抑制蛋白质合成。它可研究细菌和寄生虫感染。 | |||
T0956 |
Avermectin B1
Avermectin B1a-Avermectin B1b mixt.,Abamectin,阿维菌素 |
Antibiotic; Parasite; Autophagy | Autophagy; Microbiology/Virology |
Avermectin B1 是驱虫杀虫剂。 | |||
TN3500 |
beta-Amyrone
β-Amyron,β-香树脂酮 |
COX; AChR; PPAR; Antifection | DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience |
beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性,EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。 | |||
T0974 |
Novobiocin Sodium
Albamycinsodium,新生霉素钠,Cathomycin,Albamycin |
Potassium Channel; DNA gyrase; Topoisomerase; Antibacterial; Antibiotic; ABC; Autophagy | Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology |
Novobiocin Sodium (Albamycinsodium) 是源自 Streptomyces niveus 的抗生素。 它的化学结构类似于香豆素。Novobiocin 与 DNA 促旋酶结合并阻断三磷酸腺苷活性。 | |||
T1505 |
Imipenem monohydrate
N-Formimidoyl thienamycin monohydrate,亚胺培南,Imipenem,亚胺培南一水物 |
Antibacterial; Antibiotic | Microbiology/Virology |
Imipenem monohydrate (Imipenem) 是从微生物 Streptomyces cattleya 分离得到的碳青霉烯类抗生素,是一种用于静脉注射的β 内酰胺类抗生素,作用于细菌细胞壁,能广泛有效抑制多种革兰氏阳性和阴性菌。 | |||
T8261 |
Ceftazidime Pentahydrate
头孢他啶五水合物,头孢他啶 |
Antibacterial; Antibiotic | Microbiology/Virology |
Ceftazidime pentahydrate 是一种β-内酰胺类抗菌剂,对革兰氏阳性和革兰氏阴性需氧细菌有广谱活性,可静脉内或肌肉给药。它对肠杆菌科特别有效,对大多数 β-内酰胺酶具有抗水解作用。 | |||
T0194 |
Chloroquine phosphate
Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate |
SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Chloroquine phosphate (Aralen phosphate) 是广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。它是autophagy 和toll-like receptors 抑制剂,有效抑制SARS-CoV-2(COVID-19) 感染 (EC50=1.13 μM)。 | |||
T4816 |
6-Hydroxynicotinic acid
6-Hydroxypyridine-3-carboxylic acid,6-羟基烟酸,2-Hydroxy-5-pyridinecarboxylic acid |
Others; Endogenous Metabolite | Metabolism; Others |
6-Hydroxynicotinic acid (6-Hydroxypyridine-3-carboxylic acid) 用于核磁共振波谱或气相色谱-质谱法诊断尿路感染中的铜绿假单胞菌。在引起尿液感染的常见细菌中,只有铜绿假单胞菌从烟酸中产生6-羟基烟酸。 | |||
T2S0257 |
Dehydroandrographolide succinate
|
Others; Influenza Virus | Microbiology/Virology; Others |
Dehydroandrographolide succinate 是从中药穿心莲中提取的一种天然产物,具有免疫刺激、抗感染和抗炎作用,有潜力研究病毒性肺炎和病毒性上呼吸道感染。 | |||
T3S1852 |
Cephaeline hydrochloride
|
Others; Virus Protease; Influenza Virus | Microbiology/Virology; Others |
Cephaeline hydrochloride 是 Indian Ipecac 中的一种酚类生物碱。它有效抑制病毒 ZIKV 和 EBOV 感染。 | |||
T38375 |
Pseudane IX
2-nonyl-4-hydroxyquinoline,2-nonyl-1H-quinolin-4-one,2-nonyl-4(1h)-quinolone |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Pseudane IX (2-nonyl-1H-quinolin-4-one) 可减少丙型肝炎病毒 (HCV) 对 Huh 7.5 细胞的感染,IC50 为 1.4 μg/ml。 | |||
T0729 |
Benzyl benzoate
Ascabiol,Novoscabin,Scabitox,苯甲酸苄酯,Benzoic acid benzyl ester |
Parasite | Microbiology/Virology |
Benzyl benzoate (Benzoic acid benzyl ester) 是化妆品中的香料成分,可研究疥疮和蠕形螨相关的炎症性皮肤病。 | |||
T8257 |
Maduramicin ammonium
Maduramicin,Maduramycin Ammonium,马杜霉素铵盐 |
Apoptosis; Antibacterial; Antibiotic | Apoptosis; Microbiology/Virology |
Maduramicin ammonium (Maduramycin Ammonium) 是从放线菌Actinomadura rubra 中分离出来的。它是一种抗球虫药,可用于艾美耳球菌,腺苷球菌,鸡血肠球菌和分散肠球菌感染的相关研究。它诱导鸡心肌细胞凋亡。 | |||
TN1877 |
Lonicerin
忍冬苦苷,金银花 |
Apoptosis; Antibacterial | Apoptosis; Microbiology/Virology |
Lonicerin 是一种抗藻酸盐分泌蛋白的黄酮类化合物,对铜绿假单胞菌有抑制作用。它可预防脂多糖诱导的急性肺损伤的炎症和细胞凋亡。 | |||
T3667 |
Kalii Dehydrographolidi Succinas
Ddhads,穿琥宁,Dehydroandrographolide Succinate Potasium Salt |
Others | Others |
Kalii Dehydrographolidi Succinas (Dehydroandrographolide Succinate Potasium Salt) 从中药穿心莲中提取得到,具有免疫刺激、抗感染和抗炎作用,对病毒性肺炎和病毒性上呼吸道感染具有潜在的研究价值。 | |||
T34295 |
Resiniferatoxin
RTX,[3H]resiniferatoxin,树脂毒素 |
IL Receptor | Immunology/Inflammation |
Resiniferatoxin ([3H]resiniferatoxin) 抑制 Th1 细胞因子的产生,有助于防御 T.spiralis 感染,并可用于免疫反应调节剂的研究。 | |||
T16165 |
Myriocin
ISP-I,Thermozymocidin |
HCV Protease; Antifungal | Microbiology/Virology; Proteases/Proteasome |
Myriocin (Thermozymocidin) 是一种从 Myriococcum albomyces 中得到的代谢产物,是一种丝氨酸-棕榈酰转移酶 (SPT) 抑制剂,具有潜在的抗肿瘤抗癌和抗寄生虫活性,通过 PI3K/Akt/mTOR 通路调节巨噬细胞极化和功能来抑制肿瘤生长。Myriocin 抑制 HCV 感染,可用于研究神经病变和真菌感染。 | |||
T3810 |
Saikosaponin B2
柴胡皂苷 B2,柴胡皂甙 B2 |
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Saikosaponin B2 是从柴胡根中分离得到的一种活性成分,可抑制 HCV 病毒感染的侵入,有抗癌作用。 | |||
TN3048 |
4-Methoxycinnamaldehyde
p-Methoxycinnamaldehyde |
RSV | Microbiology/Virology |
4-Methoxycinnamaldehyde (p-Methoxycinnamaldehyde) 是 Agastache rugosa 的一种活性成分。4-Methoxycinnamaldehyde 对人喉癌细胞系中的呼吸道合胞病毒 (RSV) 具有细胞保护活性,有助于控制 RSV 感染诱发的疾病,IC50 约为 0.055 μg/mL。 | |||
T3S0057 |
Dihydrochelerythrine
12,13-Dihydrochelerythrine,二氢白屈菜红碱 |
Antifungal | Microbiology/Virology |
Dihydrochelerythrine (12,13-Dihydrochelerythrine) 是一种从榕树叶片分离出的天然化合物,具有抗真菌活性,有潜力治疗多丝蚴引起的严重感染。 | |||
T6S1885 |
Benzoylmesaconine
Mesaconine 14-benzoate,苯甲酰新乌头原碱 |
Others | Others |
Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。 | |||
T1165 |
Ethionamide
Bayer 5312,乙硫异烟胺,2-ethylthioisonicotinamide,Ethinamide |
Dehydrogenase; CAT; Antibacterial; Antibiotic | Metabolism; Microbiology/Virology; oxidation-reduction |
Ethionamide (2-ethylthioisonicotinamide) 是一种抗结核抗生素。 | |||
T6S0525 |
Farrerol
|
ERK; p38 MAPK; Akt | Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Farrerol 是一种杜鹃花的生物活性成分,具有抗氧化、抗肿瘤、抗炎、神经保护和肝保护等多种功能。 | |||
TN5263 |
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Xanthohumol,黄腐酚 |
Apoptosis; BCL; PARP; HCV Protease; IAP; Caspase; HIV Protease; NMDAR; p53 | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
1-[2,4-Dihydroxy-6-methoxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one (Xanthohumol) 是一种从蛇麻草中提纯的具有多种生物功能的天然产物。黄腐酚对 HIV-1 有效,可能是一种有趣的先导化合物。它可能代表一种用于 HIV-1 感染的新型化疗药物。 | |||
T6S1572 |
Sauchinone
|
ERK; p38 MAPK; NF-κB | MAPK; NF-κB |
Sauchinone 是一种从Saururus chinensis 中获得的非对映异构的木脂素。它通过抑制I-κBα磷酸化和p65核易位来抑制 LPS 诱导的 iNOS,TNF-α 和 COX-2 表达。它具有抗炎和抗氧化活性。 | |||
T37753 |
Aureusimine B
|
Cysteine Protease; Antibacterial | Microbiology/Virology; Proteases/Proteasome |
Aureusimine B 是一种钙蛋白酶抑制剂,由金黄色葡萄球菌生物膜产生,可能是金黄色葡萄球菌生物膜感染的潜在生物标志物。 | |||
TN1722 |
Hamamelitannin
|
Antifection | Microbiology/Virology |
Hamamelitannin 是分离自 Hamamelis virginiana 树皮的一种多酚,是群体感应抑制剂。它通过影响肽聚糖生物合成和 eDNA 释放增加金黄色葡萄球菌生物膜的抗生素敏感性。 | |||
T37876 |
Fengycin
|
Others | Others |
Fengycin is a cyclic lipopeptide used as an agricultural fungicide. Fengmycin has an anti-fungal infection effect by damaging the target’s cell membrane[1]. [1]. Sreyoshi Sur, et al. Selectivity and Mechanism of Fengycin, an Antimicrobial Lipopeptide, from Molecular Dynamics. J Phys Chem B. 2018 Mar 1;122(8):2219-2226. | |||
T11895 |
Luteolin-7-rutinoside
|
Others | Others |
Luteolin-7-rutinoside has both antifungal activities and anti-arthritic, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection. | |||
TN3809 |
Dehydrojuncusol
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Dehydrojuncusol, a new inhibitor of hepatitis C virus RNA replication, it inhibits infection of different HCV genotypes by targeting the NS5A protein and is active against resistant HCV variants frequently found in patients with treatment failure. | |||
TN1649 |
Frangulin A
|
Others | Others |
Frangulin A 保护葡萄叶免受葡萄单胞菌感染,并抑制葡萄藤的生物营养菌丝发育。 | |||
TN5079 |
Sulochrin
|
HCV Protease; Antifection | Microbiology/Virology; Proteases/Proteasome |
Sulochrin shows antifungal and antibacterial activities, it can inhibit hepatitis C virus (HCV) infection in a dose-dependent manner without any apparent cytotoxicity up to 50 uM. Sulochrin has an inhibitory activity to eosinophil degranulation. | |||
T75450 |
P-orlandin
|
Others | Others |
P-orlandin,一种真菌代谢产物,具有阻止FREP1与其配子体或[卵动细胞]结合的功能。该化合物能有效抑制蚊子体内的恶性疟原虫感染。 | |||
T38295 |
Calpinactam
|
Others | Others |
Calpinactam is a fungal metabolite originally isolated from M. alpina that has antimycobacterial activity. It is active against M. smegmatis (MIC = 0.78 μg/ml) but not a panel of 13 other bacteria and fungi. Calpinactam increases survival in a silkworm model of M. smegmatis infection (ED50 = 5 μg/larva). | |||
T13199 |
Triacsin C
WS 1228A,FR 900190 |
Others | Others |
Triacsin C (WS 1228A) 来自金黄色链霉菌 (Streptomyces aureofaciens) ,是一种花生四烯酰辅酶A合成酶和非特异性长链酰辅酶A合成酶的差异抑制剂,抗动脉粥样硬化活性,抑制 ACSL 活性, 抑制 TAG 积聚成脂滴 (LD) 。Triacsin C 可用于研究轮状病毒感染和阿尔茨海默症。 | |||
TN4308 |
Isolupalbigenin
|
Antifection | Microbiology/Virology |
Isolupalbigenin shows promising cytotoxic effects toward HL-60 cells (IC50 4.3 ± 0.7 to 18.0 ± 1.7 uM), it also shows in vitro inhibitory activity toward human glyoxalase I. Isolupalbigenin shows two different antibacterial activities against MRSA: direct growth inhibition and intensification of methicillin sensitivity, it could lead to the development of compounds for new approaches against MRSA infection. | |||
T79934 |
Clavirolide L
|
Others | Others |
Clavirolide L (Compound 3)为多拉贝烷二萜类化合物,源自Clavularia viridis。该化合物对HIV-1具有显著抑制效果,同时不针对RT酶,适用于HIV感染的研究。 | |||
TN1632 |
Euparin
|
Antifection | Microbiology/Virology |
Euparin exhibits a moderate antioxidant activity, it also exhibits antifungal activity against Trichophyton mentagrophytes. Euparin has antiviral activity, it exerts its effect during the early events of the replication cycle, from the virus adsorption to | |||
T35751 |
Violacein
|
Others | Others |
Violacein is a bacterial metabolite originally isolated from C. violaceum that has antibacterial and antiprotozoal activities.[1] [2] It is produced by C. violaceum as a purple pigment in response to N-hexanoyl homoserine lactone , a property that has been modified to create a strain of C. violaceum used in detecting quorum-sensing molecules.[3] Violacein is active against Gram-positive bacteria, including B. subtilis and S. aureus (MICs = 0.8 and 1.6 µM, respectively). It is also active aga... | |||
T73758 |
Glycolithocholic acid 3-sulfate
|
Others | Others |
Glycolithocholic acid 3-sulfate (SLCG) 为一种胆汁酸衍生物及甘胆酸的代谢产物,具有抑制HIV-1复制的作用。该化合物在HIV感染和胆囊疾病的研究中有潜在应用价值。 | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00047 |
IFN gamma Protein, Human, Recombinant (His & Avi)
IFN gamma,interferon,Interferon-γ,γ,IFI,干扰素,Interferon-gamma... |
Human | HEK293 Cells |
Interferon-gamma (IFN gamma) is a cytokine that plays physiologically important roles in promoting innate and adaptive immune responses. The absence of IFN gamma production or cellular responsiveness in humans and experimental animals significantly predisposes the host to microbial infection, a result that validates the physiologic importance of this cytokine in preventing infectious disease. IFN gamma Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi ... | |||
TMPY-02929 |
ENTPD2 Protein, Human, Recombinant (aa 29-460, His)
ectonucleoside triphosphate diphosphohydrolase 2,NTPDase-2,R... |
Human | Baculovirus Insect Cells |
NTPDase 2, also known as ENTPD2, belongs to the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). Members of E-NTPDase family are nucleotidases able to hydrolyze 5′-nucleoside tri- and/or diphosphates; the main role of these enzymes is the termination of purinergic signaling. NTPDases are ubiquitous and were previously shown in other parasites including the trypanosomatides of genus Leishmania and in T. brucei. NTPase activity would act as a timer and is crucial to T. gondii in... | |||
TMPY-02550 |
Eotaxin/CCL11 Protein, Human, Recombinant (His)
SCYA11,chemokine (C-C motif) ligand 11 |
Human | E. coli |
CCL11 or chemokine (C-C motif) ligand 11 is a member of the chemokine (C-C motif) ligand family. Chemokin (C-C motif) ligand 11 is a member of the chemokine family. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. Chemokines are a family of small ... | |||
TMPY-02219 |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)
NS1 Protein |
H1N1 | E. coli |
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As... | |||
TMPY-06802 |
HSV 2 (strain 333) Glycoprotein D/gD Protein (His)
|
HSV2 | HEK293 Cells |
Herpes simplex viruses (human herpesviruses types 1 and 2) commonly cause recurrent infection affecting the skin, mouth, lips, eyes, and genitals. Herpes simplex virus type 2 (HSV-2) infection is responsible for significant neurological morbidity, perhaps more than any other virus. Herpes simplex virus type 2–associated neurological disease may result from primary infection or reactivation of latent HSV-2. Common severe infections include encephalitis, meningitis, neonatal herpes, and, in immun... | |||
TMPH-01632 |
MRC1 Protein, Human, Recombinant (His)
Human mannose receptor,C-type lectin domain family 13 member... |
Human | E. coli |
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.; (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.; (Microbial infection) Interacts with Hepatitis B virus envelope protein. MRC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 69.9... | |||
TMPH-00696 |
OmpC Protein, E. coli, Recombinant
Outer membrane protein 1B,Porin OmpC,Outer membrane porin C,... |
E. coli | E. coli |
Forms pores that allow passive diffusion of small molecules across the outer membrane.; (Microbial infection) Supports colicin E5 entry in the absence of its major receptor OmpF.; (Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536; polymorphisms in extracellular loops 4 and 5 of OmpC confer susceptibility to CdiA-EC536-mediated toxicity. | |||
TMPY-04144 |
Kremen-1 Protein, Human, Recombinant (His)
KREMEN,KRM1,kringle containing transmembrane protein 1 |
Human | HEK293 Cells |
KREMEN1 (Kringle Containing Transmembrane Protein 1) is a Protein Coding gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The cell surface molecule KREMEN1 is an entry receptor for coxsackievirus A1 (CV-A10). Whereas loss of KREMEN1 renders cells resistant to CV-A10 infection, KREMEN1 overexpression enhances CV-A10 binding to the cell surface and increases susceptibility... | |||
TMPK-01230 |
CLEC2D Protein, Human, Recombinant (hFc & Avi)
Lectin-like NK cell receptor,LLT-1,OCIL,LLT1,Lectin-like tra... |
Human | HEK293 Cells |
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. However, this implication may be confounded by highly active anti-retroviral treatment (HAART). | |||
TMPH-01283 |
EEF1A1 Protein, Human, Recombinant (His)
EF-1-alpha-1,EEF1A,EEF1A1,Elongation factor 1-alpha 1,EF1A,e... |
Human | E. coli |
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.; (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. | |||
TMPH-01672 |
Human metapneumovirus (strain CAN97-83) Matrix protein (His & Myc)
M,Matrix protein,M protein |
HMPV | E. coli |
Plays a crucial role in virus assembly into filaments and budding. Early in infection, localizes in the nucleus where it may inhibit host cell transcription. Later in infection, traffics to the cytoplasm through the action of host CRM1 to associate with inclusion bodies, the site of viral transcription and replication. During virus assembly and budding, acts as a bridge between the nucleocapsid and the lipid bilayer. | |||
TMPK-01231 |
CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated
OCILmember D,LLT1,CLAX,CLEC2D,CLAXLLT-1,LLT-1,OCIL |
Human | HEK293 Cells |
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. | |||
TMPH-00695 |
OmpC Protein, E. coli, Recombinant (His)
Outer membrane protein C,ompC,Outer membrane porin C,Porin O... |
E. coli | E. coli |
Forms pores that allow passive diffusion of small molecules across the outer membrane.; (Microbial infection) Supports colicin E5 entry in the absence of its major receptor OmpF.; (Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536; polymorphisms in extracellular loops 4 and 5 of OmpC confer susceptibility to CdiA-EC536-mediated toxicity. | |||
TMPH-00697 |
OmpF Protein, E. coli, Recombinant (His & Myc)
Outer membrane protein F,Outer membrane porin F,Porin OmpF,o... |
E. coli | E. coli |
Forms pores that allow passive diffusion of small molecules across the outer membrane.; (Microbial infection) It is also a receptor for the bacteriophage T2. Is the major receptor for colicin E5.; (Microbial infection) A mixed OmpC-OmpF heterotrimer is the outer membrane receptor for toxin CdiA-EC536; polymorphisms in extracellular loops 4 and 5 of OmpC confer susceptibility to CdiA-EC536-mediated toxicity. | |||
TMPH-00033 |
ASFV (strain Ba71V) p30 Protein (His)
Ba71V-93,Phosphoprotein p30,p30,CP204L,Phosphoprotein p32 |
ASFV | E. coli |
Modifies the subcellular distribution of heterogeneous nuclear ribonucleoprotein K (HNRNPK) and may contribute to modulate HNRNPK functions related to processing and export of mRNAs during ASFV infection. | |||
TMPH-01284 |
EEF1A1 Protein, Human, Recombinant
EF-Tu,LENG7,EEF1A,eEF1A-1,EF1A,EF-1-alpha-1,EEF1A1,Elongatio... |
Human | E. coli |
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.; (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. | |||
TMPH-01673 |
Human metapneumovirus (strain CAN97-83) Matrix protein (His)
M,Matrix protein,M protein |
HMPV | P. pastoris (Yeast) |
Plays a crucial role in virus assembly into filaments and budding. Early in infection, localizes in the nucleus where it may inhibit host cell transcription. Later in infection, traffics to the cytoplasm through the action of host CRM1 to associate with inclusion bodies, the site of viral transcription and replication. During virus assembly and budding, acts as a bridge between the nucleocapsid and the lipid bilayer. | |||
TMPH-01600 |
Lactoperoxidase/LPO Protein, Human, Recombinant (His & Myc)
LPO,Salivary peroxidase,Lactoperoxidase |
Human | HEK293 Cells |
Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May contribute to airway host defense against infection. | |||
TMPH-01575 |
KRT10 Protein, Human, Recombinant (His)
Keratin, type I cytoskeletal 10,Keratin-10,Cytokeratin-10,KR... |
Human | E. coli |
Plays a role in the establishment of the epidermal barrier on plantar skin.; (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.; (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occu... | |||
TMPH-00133 |
AcMNPV Major capsid Protein (His & Myc)
VP39,P39 |
AcMNPV | E. coli |
Most abundant structural protein of the nucleocapsid produced during the infection cycle. The monomers are arranged in stacked rings around the nucleoprotein core. AcMNPV Major capsid Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 46.4 kDa and the accession number is P17499. | |||
TMPK-01467 |
HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Monomer Protein, Human, MHC (His & Avi)
HPV16,E6,Human papillomavirus type 16 |
Human | HEK293 Cells |
Human papillomavirus (HPV) 16 infection is a necessary condition for the pathogenesis and development of cervical cancer. The E6 protein is expressed by the HPV16 E6 gene and promotes malignant phenotype transformation, which is an important mechanism for the occurrence and development of cervical cancer. | |||
TMPH-00548 |
Epstein-Barr virus (strain B95-8) BZLF1 Protein (His & SUMO)
Zta,Trans-activator protein BZLF1,Lytic switch protein BZLF1... |
EBV | E. coli |
Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1). | |||
TMPH-02239 |
TMPRSS4 Protein, Human, Recombinant (His & Myc)
Channel-activating protease 2,TMPRSS4,Transmembrane protease... |
Human | E. coli |
Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC.; (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. TMPRSS4 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10... | |||
TMPK-00550 |
CD55/DAF Protein, Cynomolgus, Recombinant (His)
TC,DAF-GPI,CR,CROM,Daf1,CD55,Cd55a,DAF |
Cynomolgus | HEK293 Cells |
Decay Accelerating Factor (or CD55) is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection. | |||
TMPY-04904 |
Zika virus (ZIKV) (strain Zika SPH2015) M/Membrane protein (Fc)
|
ZIKV | HEK293 Cells |
Zika virus (ZIKV) infection causes microcephaly and has been linked to other brain abnormalities. ZIKV has a more selective and larger impact on the expression of genes involved in DNA replication and repair. P53 inhibitors can block the apoptosis induced by ZIKV-M in hNPCs. | |||
TMPY-02516 |
Interferon alpha 10/IFNA10 Protein, Human, Recombinant (hFc)
interferon, α10,interferon, alpha 10,IFN-alphaC,MGC119879,干扰... |
Human | HEK293 Cells |
Interferon alpha-10 (IFNA10) is a member of the interferon family. Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogen... | |||
TMPK-01466 |
HLA-A*02:01&B2M&HPV 16 E6 (KLPQLCTEL) Tetramer Protein, Human, MHC (His & Avi)
Human papillomavirus type 16,E6,HPV16 |
Human | HEK293 Cells |
Human papillomavirus (HPV) 16 infection is a necessary condition for the pathogenesis and development of cervical cancer. The E6 protein is expressed by the HPV16 E6 gene and promotes malignant phenotype transformation, which is an important mechanism for the occurrence and development of cervical cancer. | |||
TMPH-00549 |
Epstein-Barr virus (strain GD1) BZLF1 Protein (His & Myc)
bZIP transcription factor ZEBRA,Lytic switch protein BZLF1,T... |
EBV | E. coli |
Plays a key role in the switch from latent infection to lytic cycle producing new virions. Acts as a transcription factor, inducing early lytic cycle genes, and as a origin binding protein for genome replication. BZLF1 activates the promoter of another EBV gene (BSLF2+BMLF1). | |||
TMPH-03021 |
PstP Protein, Mycobacterium tuberculosis, Recombinant (His)
Mycobacterial Ser/Thr phosphatase,PP2C-family Ser/Thr phosph... |
Mycobacterium tuberculosis | E. coli |
Plays an important role in regulating cell division and growth by reversible phosphorylation signaling. May play important roles in regulating cellular metabolism and signaling pathways, which could mediate the growth and development of the cell. Plays a role in establishing and maintaining infection. | |||
TMPH-00151 |
IBV (strain UK/142/86) Spike glycoprotein (His)
S,Peplomer protein,Spike glycoprotein,E2 |
IBV | E. coli |
S1 attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection. IBV (strain UK/142/86) Spike glycoprotein (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 27.1 kDa and the accession number is P30207. | |||
TMPH-00152 |
IBV (strain UK/167/84) Spike glycoprotein (His)
Spike glycoprotein,S,E2,Peplomer protein |
IBV | E. coli |
S1 attaches the virion to the cell membrane by interacting with cell receptors, initiating the infection. IBV (strain UK/167/84) Spike glycoprotein (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 27.1 kDa and the accession number is P30208. | |||
TMPK-01412 |
HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi)
SARS-CoV-2 epitope,MHC |
Human | HEK293 Cells |
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype. | |||
TMPK-01267 |
TREM-1 Protein, Cynomolgus, Recombinant (His)
CD354,TREM-1 |
Cynomolgus | HEK293 Cells |
TREM1 (Triggering Receptor Expressed on Myeloid Cells 1) is a pro-inflammatory receptor expressed by phagocytes, which can also be released as a soluble molecule (sTREM1). The roles of TREM1 and sTREM1 in liver infection and inflammation are not clear. | |||
TMPH-01550 |
Interferon kappa/IFNK Protein, Human, Recombinant (His & SUMO)
Interferon kappa,IFNK |
Human | E. coli |
May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. | |||
TMPH-00761 |
Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant
Cutin hydrolase,CUTA,Cutinase |
Neocosmosporum cucurbitae | E. coli |
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 22.4 kDa and the accession number is Q99174. | |||
TMPH-01457 |
Human herpesvirus 6B (HHV-6 variant B) (strain Z29) mRNA export factor ICP27 homolog (His & Myc)
mRNA export factor ICP27 homolog |
HHV-6B | E. coli |
Immediate early (EI) protein that plays many roles during productive infection including regulation of viral gene expression and nuclear export of intronless viral RNAs. Human herpesvirus 6B (HHV-6 variant B) (strain Z29) mRNA export factor ICP27 homolog (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.6 kDa and the accession number is P52539. | |||
TMPK-00134 |
ULBP-1 Protein, Human, Recombinant (His & Avi)
ALCAN-beta,ALCAN-β,ULBP-1,MULT-1,NKG2D ligand 1,AET1I,NKG2DL... |
Human | HEK293 Cells |
Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natural killer (NK) cells. ULBP-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.2 kDa and the accession number is Q9BZM6. | |||
TMPK-00308 |
Nectin-4 Protein, Human, Recombinant (His & Avi)
PVRL4,LNIR,NECTIN4,PRR4,EDSS1 |
Human | HEK293 Cells |
Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus. Nectin-4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 37.2 kDa and the accession number is Q96NY8. | |||
TMPH-02989 |
ESAT-6 Protein, Mycobacterium bovis, Recombinant (His & Myc)
ESAT-6,6 kDa early secretory antigenic target,esxA |
Mycobacterium bovis | E. coli |
A secreted protein. Acts as a strong host T-cell antigen. Plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm. ESAT-6 Protein, Mycobacterium bovis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.2 kDa and the accession number is P0A565. | |||
TMPK-00705 |
MASP2 Protein, Human, Recombinant (His)
MAP19,sMap,MASP-2,MASP1P1 |
Human | E. coli |
The pathogenesis of severe acute respiratory disease syndrome (SARS) is not fully understood. One case-control study has reported an association between susceptibility to SARS and mannan-binding lectin (MBL) in China. As the downstream protein of MBL, variants of the MBL-associated serine protease-2 (MASP2) gene may be associated with SARS coronavirus (SARS-CoV) infection in the same population. | |||
TMPK-00255 |
CD209/DC-SIGN Protein, Human, Recombinant (His)
CD209,DC-SIGN,CLEC4L,CD209 molecule,DC-SIGN1,MGC129965,CDSIG... |
Human | HEK293 Cells |
C-type lectin CD209/DC-SIGN and CD209L/L-SIGN proteins are distinct cell adhesion and pathogen recognition receptors that mediate cellular interactions and recognize a wide range of pathogens, including viruses such as SARS, SARS-CoV-2, bacteria, fungi and parasites. Pathogens exploit CD209 family proteins to promote infection and evade the immune recognition system. | |||
TMPH-00760 |
Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant (His)
Cutin hydrolase,CUTA,Cutinase |
Neocosmosporum cucurbitae | P. pastoris (Yeast) |
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Fusarium solani subsp. Cucurbitae, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 23.7 kDa and the accession number is Q99174. | |||
TMPH-00424 |
Cutinase Protein, Colletotrichum capsici, Recombinant (His & SUMO)
Cutinase,CUTA,Cutin hydrolase |
Colletotrichum capsici | E. coli |
Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle. Allows pathogenic fungi to penetrate through the cuticular barrier into the host plant during the initial stage of the fungal infection. Cutinase Protein, Colletotrichum capsici, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.0 kDa and the accession number is P10951. | |||
TMPK-00135 |
ULBP-1 Protein, Human, Recombinant (His & Avi), Biotinylated
ALCAN-β,NKG2D ligand 1,ULBP-1,NKG2DL,MULT-1,ULBP1,ALCAN-beta... |
Human | HEK293 Cells |
Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natural killer (NK) cells. ULBP-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.2 kDa and the accession number is Q9BZM6. | |||
TMPH-01104 |
Claudin-9 Protein-VLP, Human, Recombinant (His)
CLDN9,Claudin-9 |
Human | HEK293 Cells |
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. Claudin-9 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 24.2 kDa and the accession number is O95484. | |||
TMPK-01416 |
HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein, Human, MHC (His & Avi), Biotinylated
MHC,SARS-CoV-2 epitope |
Human | HEK293 Cells |
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype. | |||
TMPJ-00744 |
Toxin B Protein, Vibriocholerae, Recombinant
Cholera enterotoxin γ chain,Choleragenoid,Cholera enterotoxi... |
Vibrio cholerae | E. coli |
Cholera toxin is protein complex secreted by the bacterium Vibrio cholerae. It is responsible for the massive, watery diarrhea characteristic of cholera infection. Cholera enterotoxin subunit B (CTXB) pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself. | |||
TMPH-01269 |
SMURF2 Protein, Human, Recombinant (His)
SMAD ubiquitination regulatory factor 2,E3 ubiquitin-protein... |
Human | E. coli |
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby downregulating TGF-beta signaling. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1. Also forms a stable com... | |||
TMPH-03022 |
PstP Protein, Mycobacterium tuberculosis, Recombinant
PP2C-family Ser/Thr phosphatase,pstP,Serine/threonine protei... |
Mycobacterium tuberculosis | E. coli |
Plays an important role in regulating cell division and growth by reversible phosphorylation signaling. May play important roles in regulating cellular metabolism and signaling pathways, which could mediate the growth and development of the cell. Plays a role in establishing and maintaining infection. PstP Protein, Mycobacterium tuberculosis, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 25.3 kDa and the accession number is P9WHW4. | |||
TMPH-02981 |
Mumps virus (strain RW) Hemagglutinin-neuraminidase Protein (His)
HN,Hemagglutinin-neuraminidase |
MuV | E. coli |
Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.; Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins. Mumps virus (strain RW) Hemagglutinin-neuraminidase Protein (His) is expressed in E. coli expression system with N-10... | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T60016 |
VV116
GS-621763-d1,JT001 |
SARS-CoV; RSV | Microbiology/Virology |
VV116 (JT001) 是一种针对呼吸道合胞病毒和 SARS-CoV-2 感染的选择性和口服活性核苷抗病毒剂。 | |||
T73712 |
Metformin-d6 hydrochloride
1,1-Dimethylbiguanide-d6 hydrochloride |
AMPK; Autophagy | Autophagy; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Metformin-d6 hydrochloride (Metformin-d6 hydrochloride) 是 Metformin 的一种氘代化物,可用于研究 Metformin 在体内的代谢,常作为Metformin的内标。 | |||
TMIJ-0184 |
Cefditoren-d3
|
||
Cefditoren-d3 是 Cefditoren 的氘代化合物。Cefditoren 的 CAS 号为 104146-53-4。 | |||
TMIJ-0295 |
Flubendazole-d3 (methyl-d3)
|
||
Flubendazole-d3 (methyl-d3) 是 Flubendazole 的氘代化合物。Flubendazole 的 CAS 号为 31430-15-6。Flubendazole 是用于治疗人类蠕虫感染的驱虫药。它通过抑制微管功能等机制发挥抗癌作用。它诱导p53介导的细胞凋亡,抑制 G2/M 细胞周期。 | |||
T70174 |
Pirlindole-d4 HCl
|
||
Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor. It is selective for MAO-A over MAO-B. In rats, it reverses the depressive-like effects induced by chronic mild stress (CMS), increases proliferation of hippocampal neural progenitor cells, and reverses dendritic atrophy in granule neurons. Pirlindole is also an inhibitor of enterovirus-D68 and coxsackieviru... | |||
TMIH-0146 |
Chloroquine-d5
|
||
Chloroquine-d5 是 Chloroquine 的氘代化合物。Chloroquine 的 CAS 号为 54-05-7。Chloroquine 是一种自噬和 Toll 样受体抑制剂。 氯喹是一种抗疟疾和抗炎剂,广泛用于治疗疟疾和类风湿性关节炎。它在体外控制 SARS-CoV-2 (COVID-19) 感染方面非常有效,EC50 为 1.13 μM。 | |||
T36537 |
Nitrofurantoin-13C3
Nitrofurantoin-13C3 |
||
Nitrofurantoin-13C3is intended for use as an internal standard for the quantification of nitrofurantoin by GC- or LC-MS. Nitrofurantoin is a nitrofuran antibiotic.1In vivo, nitrofurantoin (25-100 mg/kg) reducesE. colireplication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates ofP. mirabilis. Nitrofurantoin also prevents alkalization of urine, as well as ca... | |||
T38297 |
Ribavirin-13C5
Ribavirin-13C5 |
||
Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro... | |||
T71055 |
Albendazole-d7
|
||
Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben... | |||
T37250 |
Cefazolin-13C2,15N
Cefazolin-13C2,15N |
||
Cefazolin-13C2,15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml). It also inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg/ml). In vivo, cefazolin protects against S. aureus, E. coli, and P. mirabilis infection in mice (ED50... | |||
T36021 |
Flumequine-13C3
Flumequine-13C3 |
||
Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3In vivo, fl... |