Fosamprenavir Calcium Salt (GW433908G) (GW433908G) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility. Fosamprenavir Calcium Salt has Anti-HIV infection.

经口灌胃给予DATS显著延缓了裸鼠体内PC-3异种移植瘤的生长，而未造成体重减轻。例如，治疗开始后20天，对照组小鼠的平均肿瘤体积约为DATS处理组小鼠的3倍。DATS处理组小鼠的肿瘤展示出与对照组肿瘤相比明显更高的凋亡体计数。与在培养的PC-3细胞中的结果一致，DATS介导的PC-3异种移植瘤生长抑制与诱导促凋亡蛋白Bax和Bak的表达相关。尽管DATS处理抑制了培养的PC-3细胞的迁移，并与血管内皮生长因子受体-2蛋白的下调有关，但通过CD31免疫染色判断，对照组和DATS处理组小鼠肿瘤的新血管形成相当[1]。

DATS was given orally (6 micromoL, thrice weekly) to male athymic mice s.c. implanted with PC-3 cells. Tumor sections from control and DATS-treated mice were examined for apoptotic bodies by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay. Protein levels of apoptosis and cell cycle regulating proteins in tumor tissues of control and DATS-treated mice were determined by immunoblotting. The effect of DATS treatment on in vivo angiogenesis was determined by immunohistochemical analysis of CD31 in tumors[1].