KDU731

Name: KDU731
Brand: TargetMol
SKU: T15651
Rating: 4.5 (1 reviews)

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产品编号 T15651Cas号 1610610-48-4

KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety. KDU731is an orally active C. parvum inhibitor of PI4K (IC50: 25 nM). KDU731 blocks Cryptosporidium infection in vitro and in vivo.

KDU731

还可以

产品编号 T15651Cas号 1610610-48-4

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品介绍

生物活性

产品描述	KDU731 is a promising drug candidate for the treatment of diarrhea caused by Cryptosporidium and meets a broad range of safety. KDU731is an orally active C. parvum inhibitor of PI4K (IC50: 25 nM). KDU731 blocks Cryptosporidium infection in vitro and in vivo.
体内活性	KDU731 (p.o.; 5 mg/kg; every 12 hours for 7 days) is tolerated in all calves, and treated calves shed obviously fewer oocysts than vehicle-treated calves in their stool. KDU731 (p.o.; 7 or 10mg/kg; 16 days) has;effective activity against Cryptosporidium in immunocompromised IFN-γ KO mice and dramatically reduces oocyst shedding[2].

化学信息

分子量	396.4
分子式	C₂₂H₁₆N₆O₂
CAS No.	1610610-48-4
密度	1.36 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 83.33 mg/mL (210.22 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5227 mL	12.6135 mL	25.2270 mL	126.1352 mL
5 mM	0.5045 mL	2.5227 mL	5.0454 mL	25.2270 mL
10 mM	0.2523 mL	1.2614 mL	2.5227 mL	12.6135 mL
20 mM	0.1261 mL	0.6307 mL	1.2614 mL	6.3068 mL
50 mM	0.0505 mL	0.2523 mL	0.5045 mL	2.5227 mL
100 mM	0.0252 mL	0.1261 mL	0.2523 mL	1.2614 mL