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Cat. No. | Product Name | ||
---|---|---|---|
L6900 | 稀有天然产物库 | 693 compounds | |
693 种稀有天然产物的集合,可以用于高通量和高内涵筛选; | |||
L7840 | 高溶解性卤化片段化合物库 | 796 compounds | |
高溶解性卤化片段库包含796 个卤化片段化合物。 | |||
DP1000 | PPI计算机辅助药物设计库 | 230000 compounds | |
ChemDiv’s Protein-Protein Interaction Library contains 210,000 compounds. 陶术生物针对小规模PPI 药物筛选,基于结构多样性构建PPI 多样性子库,包含10397种小分子化合物。 | |||
L6150 | 天然产物共价化合物库 | 583 compounds | |
提供产品的生物学信息和药物学信息,为筛选提供理论方向和研究基础; | |||
L7870 | 可溶性羧酸片段化合物库 | 1806 compounds | |
可溶性羧酸片段库包含 1806 个化合物 | |||
L7830 | 高溶解性片段药效团化合物库 | 985 compounds | |
高溶解性片段药效团库包含985 个片段小分子。 | |||
VM1400 | 多样性核心库Part2 | 25920 compounds | |
分子量<500,主要集中于250-450之间,方便后续的改造优化; | |||
L2000 | 抑制剂库 | 8328 compounds | |
8328 个小分子抑制剂的独特集合,主要用于细胞信号研究、新药筛选、高通量筛选和高内涵筛选; | |||
L9400 | PPI抑制剂库 | 485 compounds | |
485 种已知活性的 PPI 相关的抑制剂,可用于高通量、高内涵筛选; | |||
L4500 | 抗真菌库 | 252 compounds | |
252 个抗真菌活性化合物的独特集合,包含作用于真菌相关靶点的化合物和临床中用于真菌类疾病的药物,是相关疾病药物筛选的有效工具。 | |||
L8600 | 泛素化化合物库 | 210 compounds | |
210 种泛素化相关的小分子,用于高通量和高内涵筛选; | |||
L3700 | JAK-STAT 化合物库 | 252 compounds | |
252 个 JAK/STAT 靶点相关的小分子化合物的独特集合,用于高通量、高内涵筛选; | |||
L9240 | 农药化合物库 | 270 compounds | |
270种农药相关化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2540 | 肠道微生物代谢化合物库 | 614 compounds | |
614 种肠道微生物代谢物的集合,可以用于高通量和高内涵筛选; | |||
L9300 | 大环化合物库 | 210 compounds | |
210 种活性已知的大环化合物,用于高通量、高内涵筛选; | |||
L8500 | HIF-1化合物库 | 1336 compounds | |
1336 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究; | |||
DO2200 | 共价抑制剂库CD | 12000 compounds | |
数量多:超过12000种共价结合化合物,并且数量在持续增加; | |||
DO1200 | 药物靶点库 | 53200 compounds | |
数量多,含53200种小分子化合物,是高通量筛选的有力工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1199 |
Mitotane
Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦 |
Apoptosis; AChR | Apoptosis; Neuroscience |
Mitotane (NCI-C04933) 是 DDD 的同分异构体和 DDT 的衍生物,可作用于肾上腺皮质癌,有抗癌活性。 | |||
T6404 |
Bazedoxifene hydrochloride
Bazedoxifene HCl,盐酸巴多昔芬,TSE-424 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Bazedoxifene hydrochloride (TSE-424) 是一种 IL-6/GP130蛋白相互作用抑制剂,可用于胰腺癌的研究。它也是一种有口服活性的,能透过血脑屏障的,非甾体、选择性的雌激素受体调节剂 (SERM),对 ERα 和 ERβ 作用的 IC50值分别为 26 nM 和 99 nM,可用于研究骨质疏松症。 | |||
T2544 |
Bazedoxifene acetate
醋酸巴多昔芬,WAY-TES 424,TSE 424,WAY-140424 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Bazedoxifene acetate (WAY-TES 424) 是一种非甾体的、有口服活性的、选择性的雌激素受体调节剂,能够作用于 ERα (IC50:26 nM) 和 ERβ (IC50:99 nM) ,可用于研究骨质疏松症。它也是一种IL-6/GP130蛋白相互作用抑制剂,可用于研究胰腺癌。 | |||
T9184L |
Compound 3344 hydrochloride
Compound 3344 hydrochloride (2368246-78-8 free base) |
Ras | GPCR/G Protein; MAPK |
Compound 3344 hydrochloride 是 KRAS 效应相互作用的抑制剂,亲和力为 126nm。 | |||
T9954 |
K-975
|
Others | Others |
K-975是一种高选择性的具有口服活性的TEAD 抑制剂,可有效抑制TEAD 和YAP1/TAZ 之间的蛋白质-蛋白质相互作用。 | |||
T7570 |
RGD peptide (GRGDNP)
RGD peptide GRGDNP(2TFA),H-甘氨酰-精氨酰-甘氨酰-天冬氨酰-天冬酰胺酰-脯氨酸-OH,RGD peptide GRGDNP |
Apoptosis; Integrin | Apoptosis; Cytoskeletal Signaling |
RGD peptide (GRGDNP) (RGD peptide GRGDNP(2TFA)) 是一种整合素-配体相互作用的抑制剂,通过激活构象变化促进细胞凋亡,从而增强 caspase-3的活化,在细胞黏附、迁移、生长和分化中发挥重要作用。 | |||
T36411 |
9-Ethylguanine
|
Others | Others |
9-Ethylguanine 是一种模型核碱基,常用于研究 DNA 与有机金属配合物的相互作用。 | |||
T60006 |
Aromatase inhibitor 23
|
Others | Others |
Aromatase inhibitor 23 是一种针对 RAD51 重组酶家族中蛋白质-蛋白质相互作用的抑制剂。 | |||
T6023 |
Nutlin-3a
(-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3 |
Apoptosis; E1/E2/E3 Enzyme; Autophagy | Apoptosis; Autophagy; Ubiquitination |
Nutlin-3a ((−)-Nutlin-3) 是 Nutlin-3 的活性对映体,是一种 MDM2抑制剂,可抑制 MDM2-p53相互作用,稳定 p53 蛋白,从而诱导细胞自噬和凋亡,有潜力研究 TP53野生型卵巢癌。 | |||
T9544 |
Compound 1T-0216
|
Others | Others |
Compound 1T-0216 是AKT1-FAK 相互作用的阻滞剂,在不影响基础FAK 磷酸化的情况下,减少对人类SW620结肠癌细胞细胞外压力的FAK 磷酸化的刺激。 | |||
T9039 |
HIV-1 Nef-IN-1
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
HIV-1 Nef-IN-1 是 HIV-1 Nef 蛋白的抑制剂。 它有效地竞争 Nef-SH3Hck 相互作用,Kd 值为 6.7 μM。 | |||
T3635 |
IQ 1
IQ1,IQ-1 |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
IQ 1 有多种作用,如保持小鼠ESCs 的多功能性、降低Wnt 刺激的磷酸化、阻止PP2A/Nkd 的相互作用等等。 | |||
T10205 |
A-395
|
Histone Methyltransferase | Chromatin/Epigenetic |
A-395 是一种多梳抑制复合物 2 (PRC2) 蛋白质-蛋白质相互作用的拮抗剂,可有效抑制三聚体 PRC2 复合物 (EZH2-EED-SUZ12),IC50为 18 nM。 | |||
T77695 |
Muvalaplin
LY3473329 |
Others | Others |
Muvalaplin (LY3473329) 是一种具有口服活性的脂蛋白 (a) Lp (a) 抑制剂,可阻断 apo(a)-apo B100 相互作用来抑制 Lp(a) 的形成。 | |||
T38170 |
RMC-0331
RM-023 |
Raf | MAPK |
RMC-0331 (RM-023) 是一种可口服且具有高效性的 SOS1 抑制剂。RMC-0331 具有潜在的抗癌活性,通过破坏 RAS-SOS1 相互作用阻断 RAS 激活。 | |||
T9109 |
SSAA09E2
|
RAAS; SARS-CoV | Endocrinology/Hormones; Microbiology/Virology |
SSAA09E2 是一种新型的SARS-CoV 复制抑制剂,通过阻断SARS-S 与SARS-CoV 受体血管紧张素转换酶-2 的早期相互作用发挥作用。 | |||
T3112 |
Verteporfin
维替泊芬,BPD-MA,CL 318952 |
Apoptosis; YAP; VDA; Autophagy | Angiogenesis; Apoptosis; Autophagy; Stem Cells |
Verteporfin (BPD-MA) 是一种 YAP 抑制剂,抑制 YAP-TEAD 相互作用。Verteporfin 也是一种光敏剂,用于光动力疗法。Verteporfin 还可以诱导细胞凋亡,抑制自噬。 | |||
T60081 |
BV02
2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1,3-dioxoisoindoline-5-carboxylic acid |
Others | Others |
BV02 是 14-3-3 蛋白-蛋白相互作用的抑制剂,可用于治疗慢性粒细胞白血病的研究。 BV02 破坏表达 IM 抗性 T315I 突变和 IM 敏感的野生型 Bcr-Abl 的造血细胞。 | |||
T28643 |
Ex26
S1P1-IN-Ex26 |
S1P Receptor | GPCR/G Protein |
Ex26 (S1P1-IN-Ex26) 是一种具有选择性和高效性的 sphingosine 1-phosphate receptor 1 (S1P1) 拮抗剂,可破坏 SR-B1-S1PR1相互作用,抑制 S1P-S1PR1 信号转导。Ex26 可用于实验性自身免疫性脑脊髓炎、动脉粥样硬化和胃癌。 | |||
T13586L |
BPK-29 hydrochloride
|
Others | Others |
BPK-29 hydrochloride 是特殊配体,能够共价修饰 C274 ,破坏非典型孤核受体NR0B1与RBM45、SNW1蛋白质的相互作用。它能够损害KEAP1突变癌细胞的锚定独立生长。 | |||
T65550 |
Gefitinib analog III
4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate |
Others | Others |
Gefitinib analog III (4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl acetate) 具有潜在的抗炎和抗肿瘤活性,可用于研究其在生物体内的相互作用和活性。 | |||
T9849 |
HQ461
|
CDK; Molecular Glues | Cell Cycle/Checkpoint; PROTAC |
HQ461 是一种分子胶,可促进 CDK12-DDB1 相互作用并触发cyclin K降解, cyclin K 的降解会损害 CDK12 的功能,导致 CDK12 底物磷酸化降低、DNA 损伤反应基因下调和细胞死亡。 | |||
T28078 |
MMRi64
|
Apoptosis; Mdm2; p53 | Apoptosis |
MMRi64 是 Mdm2-MdmX E3 连接酶活性的特异性抑制剂。MMRi64 能有效诱导 p53 积累,并诱导白血病/淋巴瘤细胞中 p53 途径的凋亡,破坏 Mdm2-MdmX 相互作用, 下调白血病细胞中的 Mdm2 和 MdmX。MMRi64 MMRi64 可用于癌症研究。 | |||
T14299 |
AP20187
B/B Homodimerizer |
Others | Others |
AP20187 (B/B Homodimerizer) 是一种细胞渗透性配体,用于二聚化 FK506 结合蛋白 (FKBP) 融合蛋白。它启动生物信号级联和基因表达或破坏蛋白质-蛋白质相互作用。 | |||
T12078 |
ML334
LH601A |
Nrf2 | Immunology/Inflammation |
ML334 (LH601A) 是一种可穿过细胞膜且具有有效性的 NRF2 激活剂,抑制 Keap1-NRF2 蛋白质相互作用,抑制心脏成纤维细胞活化和增殖来改善心肌梗死诱导的心脏纤维化。 | |||
T63042 |
NDB
|
FXR | Metabolism |
NDB 是一种具有选择性和有效性的 hFXRα 拮抗剂,可抑制原代小鼠肝细胞中 GW4064 刺激的 FXR/RXR 相互作用和 FXRα 靶基因表达。NDB可用于研究糖尿病。 | |||
T12134 |
MYCMI-6
NSC354961 |
Apoptosis; c-Myc | Apoptosis; Cell Cycle/Checkpoint |
MYCMI-6 (NSC-354961) 是一种内源性MYC:MAX 蛋白相互作用抑制剂,选择性结合 MYC bHLHZip 域,Kd 值为 1.6 μM。它阻断 MYC 驱动的转录,以 MYC 依赖性的方式抑制肿瘤细胞的生长 ,诱导细胞凋亡。 | |||
T77725 |
YAP-TEAD-IN-3
IAG933 |
YAP | Stem Cells |
YAP-TEAD-IN-3 是 YAP/TAZ-TEAD 相互作用的抑制剂,对于 Avi-人 TEAD4217-434 的 IC50 为 9 nM。 YAP-TEAD-IN-3 抑制 YAP 报告基因表达 (IC50 = 0.048 μM) 和 NCI-H2052 细胞增殖 (IC50 = 0.048 μM)。 | |||
T83976 |
ARB-272572 hydrochloride
ARB-272572 hydrochloride(2368182-63-0 Free base) |
PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
ARB-272572 hydrochloride 是一种小分子 PD-L1 抑制剂,对PD-1/PD-L1 HTRF的 IC50 值为 400 pM。ARB-272572 hydrochloride 通过诱导 PD-L1 蛋白同源相互作用来抑制 PD-1/PD-L1 细胞信号传导。 | |||
T63771 |
Golcadomide
CC-99282,CC 99282,CC99282 |
Ligand for E3 Ligase | PROTAC |
Golcadomide (CC-99282) 是一种具有口服活性的 CRBN E3 连接酶调节剂 ,诱导 CRBN 与其新底物之间的相互作用,募集靶致病蛋白和 E3 泛素连接酶。Golcadomide 可用于研究血液系统恶性肿瘤。 | |||
T3708 |
BP-1-102
|
STAT | JAK/STAT signaling; Stem Cells |
BP-1-102 是可口服的转录因子Stat3小分子抑制剂,IC50值为 6.8 μM。 | |||
T36433 |
A2ti-2
A2ti-2 |
Virus Protease; Antiviral | Immunology/Inflammation; Microbiology/Virology |
A2ti-2 是一种亲和力较低且具有选择性的膜联蛋白 A2/S100A10 异四聚体 (A2t) 抑制剂(IC50 : 230 μM)。A2ti-2 具有抗病毒活性,可选择性破坏 A2 和 S100A10 之间的蛋白质相互作用,可防止人乳头瘤病毒 16 型 (HPV16) 感染。 | |||
T2534 |
Pitavastatin calcium
P-872441,nisvastatin,itavastatin,Pitavastatin hemicalcium,匹伐他汀钙,NK-104 |
Apoptosis; Mitophagy; Endogenous Metabolite; HMG-CoA Reductase; Autophagy | Apoptosis; Autophagy; Metabolism |
Pitavastatin calcium (NK-104) 是一种羟甲基戊二酰-CoA 还原酶抑制剂。它在 HepG2 细胞中抑制乙酸合成胆固醇的IC50为 5.8 nM。它是高效的肝细胞低密度脂蛋白胆固醇受体诱导剂。具有抗癌活性。 | |||
T74398 |
DATPT
|
Reactive Oxygen Species; Antibacterial | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
DATPT 是一种小分子 12WLVSKF17 肽模拟分子。DATPT 抑制 SNX9-p47phox 相互作用,抑制活性氧和炎性细胞因子的产生。DATPT 具有抗炎和抗菌活性,通过减少 ATP 的产生发挥作用。DATPT 是治疗脓毒症的潜在化合物。 | |||
T6531 |
Heparin sodium salt
肝素钠,Sodium heparinate,Heparin sodium |
Factor Xa; Thrombin; Autophagy | Autophagy; Metabolism; Proteases/Proteasome |
Heparin sodium salt (Sodium heparinate) 是一种抗凝血剂,可以干扰血凝过程中的多个环节。Heparin sodium salt 可以与抗凝血酶 III 可逆结合,加快凝血酶因子 IIa 和 Xa 的失活速度,从而发挥抗凝作用。 | |||
T10526 |
β-NF-JQ1
|
Others; PROTACs | Others; PROTAC |
β-NF-JQ1是一种PROTAC,可将芳烃受体E3 (AhR E3) 连接酶招募到目标蛋白上。β-NF-JQ1使用β-NF 作为AhR 配体靶向含溴odomain(BRD)的蛋白,诱导AhR 和BRD 蛋白相互作用。β-NF-JQ1显示出与蛋白敲除活性相关的强大的抗癌活性 。 | |||
T69529 |
BI-0474
|
Ras | GPCR/G Protein; MAPK |
BI-0474 是一种高效的 KRASG12C 抑制剂,对 GDP-KRAS:SOS1 蛋白-蛋白相互作用具有抑制作用,IC50 值为 7.0 nM。BI-0474 对携带 G12C 突变的 NCI-H358 细胞具有显著的抗增殖活性,在非小细胞肺癌异种移植模型中显示出显著的抗肿瘤活性。BI-0474 可用于研究癌症。 | |||
TP1895L1 |
KYL acetate(676657-00-4 free base)
|
Ephrin Receptor | Tyrosine Kinase/Adaptors |
KYL acetate(676657-00-4 free base) 是EphA4受体酪氨酸激酶抑制剂(Kd = 0.8 μM);抑制 EphA4-EphrinA5 相互作用 (IC50 = 6.34 μM)。防止 AβO 诱导的突触损伤、树突棘丢失并防止海马 CA3-CA1 传输中 LTP 的阻断。在细胞培养基中表现出较长的半衰期(在 PC3 和 C2C12 培养基中分别为 8 和 12 小时)。它有神经保护作用。 | |||
T9108 |
BI-0115
|
Lipoxygenase | Metabolism |
BI-0115 是LOX-1的选择性抑制剂,其IC50值为 5.4 µM,可以阻止细胞摄取氧化低密度脂蛋白。它通过形成同源二聚体配体结合域的二聚体来触发受体抑制。 | |||
T11230 |
ERRα antagonist-1
ERR+/- antagonist-1,ERRa antagonist-1 |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
ERRα antagonist-1 (ERR+/- antagonist-1) 是一种选择性的,高亲和力的雌激素相关受体α (ERRα) 拮抗剂。ERRα antagonist-1 抑制 ERRα 与增殖物激活的受体γ共激活因子 1α (PGC-1α) 和 PGC-1β 的相互作用,IC50 值分别为 170 nM 和 180 nM。ERRα antagonist-1 不抑制 ERRβ 或 ERRγ 与 PGC-1α 和 PGC-1β 共激活剂的相互作用,也不抑制 ERα 或 ERβ 与 PGC-1α 或 SRC-1 的相互作用。 | |||
T35841 |
5-Benzyloxygramine
|
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
5-Benzyloxygramine 是一种 N 蛋白、蛋白互作的原位稳定剂,具有抗病毒和稳定 N-NTD 蛋白的作用。它能够阻断多巴胺受体,可拮抗 5-HT 对大鼠子宫和兔耳的作用。 | |||
T70264 |
AKOS024836912
|
Others | Others |
AKOS024836912 is an inhibitor of EGF-EGFR interactions. | |||
T26567 |
ADS-103317
|
Others | Others |
ADS-103317 is an inhibitor of EGF-EGFR Interactions. | |||
T24654 |
PPT
|
Others | Others |
PPT is a modulator of water-heme interactions of CYP2C9d and CYP125A1 in low-spin P450 complexes. | |||
T69658 |
Ethyl-3,4-dephostatin
|
Others | Others |
Ethyl-3,4-dephostatin is a novel inhibitor of the interactions of CFTR-associated ligand and PSD-95/Dlg1/ZO-1 domain. | |||
T19730 |
12-Crown-4
12 C 4,12-Crown-4 ether,12C4,12-C-4 |
Others | Others |
12-Crown-4 disrupts Aβ40 fibrils. 12-Crown-4 can enter into the hydrophobic core region and form competitive, hydrophobic interactions with key hydrophobic residues. | |||
T28767 |
SGM8
|
Others | Others |
SGM8 is a covalent allosteric inhibitor of human cytomegalovirus DNA polymerase subunit Interactions. | |||
TP1117 |
IFN-α Receptor Recognition Peptide 1
IRRP1 |
||
IFN-α Receptor Recognition Peptide 1 is a peptide of IFN-α associated with receptor interactions. | |||
T69464 |
Mycro2
|
Others | Others |
Mycro2 is an inhibitor of the protein-protein interactions between the bHLHZip proteins c-Myc and Max. | |||
T24808 |
SMI-6860766
TRAFSTOP 6860766,TRAF-STOP 6860766,SMI 6860766,TRAFSTOP6860766,SMI6860766 |
Others | Others |
SMI-6860766 is a CD40-Traf6 interactions blocker that acts by ameliorating the complications of diet-induced obesity in mice. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T40370 |
2′-Deoxyadenosine 5′-monophosphate disodium
|
Endogenous Metabolite | Metabolism |
2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide present in DNA. It is employed for researching adenosine-based interactions within DNA synthesis and damage analysis. | |||
TN1513 |
Clitorin
碟豆宁,碟豆素 |
PKC; Antifection | Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology |
Clitorin 是一种山奈酚糖苷,分离自 Acalypha indica 的花和叶,表现出抗氧化活性。 | |||
T3797 |
Isosilybin
Isosilybinin,Isosilibinin,异水飞蓟宾,Silymarin,Silybin B,Q-100795 |
P450 | Metabolism |
Isosilybin (Isosilibinin) 是一种类黄酮,来源于乳蓟;能够抑制CYP3A4诱导(IC50:74 μM)。 | |||
T3S2390 |
Caftaric acid
trans-Caftaric acid,单咖啡酰洒石酸 |
Others | Others |
Caftaric acid (trans-Caftaric acid) 是一种具有抗氧化和抗炎作用的天然产物,具有抗致突变性,也是Src 家族激酶介导的蛋白质-蛋白质相互作用的抑制剂。 | |||
T5238 |
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine
1,2-Dipalmitoyl-sn-glycero-3-PE,L-磷脂酰乙醇胺,1,2-Dipalmitoyl-sn-glycerol-3-Phosphoethanolamine,1,2-DPPE |
Others; Endogenous Metabolite | Metabolism; Others |
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) 是内源性代谢产物的一种。 | |||
T5567 |
Tetradecanedioic acid
十四烷二酸,Tetradecanedicarboxylate |
Others; Endogenous Metabolite | Metabolism; Others |
Tetradecanedioic acid (Tetradecanedicarboxylate) 是一种长链脂肪酸,属于内源性代谢物的一种。它能够作为有机阴离子转运多肽介导的药物-药物相互作用的候选生物标志物。 | |||
T20089 |
ATP
Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate |
Endogenous Metabolite | Metabolism |
ATP (Adenosine triphosphate) 可为细胞提供能量,参与整体能量平衡,维持细胞内稳态。ATP 可以通过与特异性嘌呤能受体的相互作用充当细胞外信号分子,以介导神经传递、炎症、细胞凋亡和骨重塑等多种过程。 | |||
T16223 |
N-Dodecyl-β-D-maltoside
十二烷基-β-D-麦芽糖苷,Lauryl Maltoside |
Others | Others |
N-Dodecyl-β-D-maltoside (Lauryl Maltoside) 是一种芘 (Py) 的衍生物。它可用作烷基吡喃麦芽糖苷清洁剂,尤其是在转运蛋白和呼吸复合物中。它已用于诸如 RNA 聚合酶的纯化和稳定化,以及蛋白质-脂质相互作用的检测的应用中。 | |||
T5S2361 |
Epiberberine
|
ERK; Beta-Secretase; MEK; BACE; AMPK; AChR; AChE | Chromatin/Epigenetic; MAPK; Neuroscience; PI3K/Akt/mTOR signaling |
Epiberberine 是一种从黄连中得到的生物碱,是AChE 和BChE 抑制剂,和非竞争性BACE1抑制剂。在 3T3-L1 细胞分化早期,它能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。它具有抗氧化作用,能够清除 ONOO-,可用于阿尔滋海默症和糖尿病的研究。 | |||
T39219 |
Ficusonolide
|
Others | Others |
Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase. | |||
TN4404 |
Ladanein
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Ladanein is a phytochemicals inhibitor that is known to disrupt the interactions of core and other hepatitis C virus (HCV) proteins.Ladanein possesses free radicals DPPH and ABTS +.scavenging activity, it also displays moderate (20-40 microM) activities against K562, K562R (imatinib-resistant), and 697 human leukemia cell lines. | |||
T10194 |
7-Methylguanine
|
Others | Others |
7-Methylguanine is a metabolite of DNA methylation. It can be generated by methylating agents and used as a probe of DNA–protein interactions and a key component of the DNA sequencing method. | |||
T72579 |
Dihydroaltenuene B
|
Others | Others |
Dihydroaltenuene B 是一种有效的 mushroomtyrosinase 抑制剂,IC50为 38.33 µM。Dihydroaltenuene B 显示了 3-OH 和 4'-OH 与酪氨酸酶的 His244、Met280 和 Gly281 残基之间的氢键相互作用。 | |||
T73205 |
Praelolide
|
Others | Others |
Praelolide是一种有效的Nrf2激活剂,能够抑制破骨细胞的生成与活性氧(ROS)的产生,并通过与Keap1的非共价结合,破坏Keap1-Nrf2蛋白质-蛋白质相互作用。因此,Praelolide展现出在破骨细胞性骨病研究中的应用潜力。 | |||
TN2945 |
3-Hydroxybakuchiol
|
ATPase; Caspase | Apoptosis; Membrane transporter/Ion channel; Proteases/Proteasome |
3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial perm | |||
T37810 |
6',7'-Epoxybergamottin
|
Others | Others |
6'7'-Epoxybergamottin is a furanocoumarin found in grapefruit. It is a potent inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 with an IC50 value of 0.30 ppm in a cell-free assay, 0.33 μM in HL7 human liver cells, and 0.22 μM in S9 human intestine cells. It has been studied in the context of drug interactions with grapefruit constituents. It is found in grapefruit juice at concentrations of 0.1-7.4 μM and inhibits the transport of talinolol , a permeability glycoprotein (P-gp/ABCB1) transpo... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01009 |
TGFBI Protein, Human, Recombinant (His)
CDG2,CSD,EBMD,CSD1,CDGG1,CSD3,transforming growth factor, be... |
Human | HEK293 Cells |
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondral bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dys... | |||
TMPK-01392 |
Tenascin Protein, Human, Recombinant (His)
Tenascin-C,TNC,TN,Hexabrachion,Hxb,TN-C |
Human | HEK293 Cells |
Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin. Tenascin-C has many extracellular binding partners, including matrix components, soluble factors and pathogens; it also influences cell phenotype directly through interactions with cell surface receptors. Tena... | |||
TMPK-01393 |
Tenascin Protein, Mouse, Recombinant (His)
Hexabrachion,Hxb,TN-C,TN,TNC,Tenascin-C |
Mouse | HEK293 Cells |
Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin. Tenascin-C has many extracellular binding partners, including matrix components, soluble factors and pathogens; it also influences cell phenotype directly through interactions with cell surface receptors. Tena... | |||
TMPY-02292 |
IGSF11 Protein, Human, Recombinant (His)
CT119,immunoglobulin superfamily, member 11,BT-IgSF,Igsf13,C... |
Human | HEK293 Cells |
Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to overexpressed in colorectal cancers and hep... | |||
TMPY-04329 |
Vimentin Protein, Human, Recombinant (His)
CTRCT30,HEL113,vimentin |
Human | Baculovirus Insect Cells |
Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. ... | |||
TMPY-04989 |
Galectin-9 Protein, Human, Recombinant (hFc)
LGALS9A,lectin, galactoside-binding, soluble, 9,HUAT |
Human | HEK293 Cells |
LGALS9 (Galectin 9) is a Protein Coding gene. 6 alternatively spliced human isoforms have been reported. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or i... | |||
TMPY-03650 |
BirA Protein, E. coli, Recombinant (His & MBP)
BirA,dhbB,bioR |
E. coli | E. coli |
The enzyme BirA is a key reagent because of its ability to biotinylate proteins at a specific residue in a recognition sequence. This enzyme is used to biotinylate the C termini of membrane proteins, allowing these proteins to be tetramerized by binding to streptavidin. Because of the specificity of the biotinylation at the C terminus, the orientation of the membrane proteins on the streptavidin is equivalent to that of the native protein on the cell surface. These tetrameric proteins can be use... | |||
TMPY-00117 |
FGF-16 Protein, Human, Cynomolgus, Recombinant
fibroblast growth factor 16 |
Human,Cynomolgus | Baculovirus Insect Cells |
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ... | |||
TMPY-03431 |
HDAC4 Protein, Human, Recombinant (aa 612-1084)
histone deacetylase 4,HA6116,HDAC-4,HD4,BDMR,HDAC-A,AHO3,HDA... |
Human | Baculovirus Insect Cells |
HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Th... | |||
TMPY-02030 |
CD82 Protein, Human, Recombinant (His)
CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,TSPAN27,ST6,IA4,GR1... |
Human | HEK293 Cells |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud... | |||
TMPY-01648 |
TREML2 Protein, Human, Recombinant (His)
TLT2,dJ238O23.1,triggering receptor expressed on myeloid cel... |
Human | HEK293 Cells |
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune respons... | |||
TMPY-00105 |
Recombinant Protein G
|
E. coli | |
Protein G is a bacterial cell wall protein expressed at the cell surface of certain group C and group G Streptococcal strains. It has affinity for both Fab- and Fc-fragments of human IgG by independent and separate binding sites. Binding to the Fc region of immunoglobulins from several species by a non-immune mechanism exhibits great affinity for almost all mammalian immunoglobulin G (IgG) classes, including all human IgG subclasses (IgG1, IgG2, IgG3 and IgG4) and also rabbit, mouse, and goat Ig... | |||
TMPH-02134 |
U2AF1 Protein, Human, Recombinant (GST)
U2 auxiliary factor 35 kDa subunit,U2AF1,U2 snRNP auxiliary ... |
Human | E. coli |
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. U2AF1 Protein, Human, Recombinant (GST) is expressed in E. coli expression ... | |||
TMPH-02266 |
TNFAIP6 Protein, Human, Recombinant (His & Myc)
TNFAIP6,Tumor necrosis factor-inducible gene 6 protein,Tumor... |
Human | Baculovirus Insect Cells |
Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. | |||
TMPH-02306 |
VTI1B Protein, Human, Recombinant (His & SUMO)
Vti1-rp1,VTI1B,Vesicle transport through interaction with t-... |
Human | E. coli |
V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. | |||
TMPK-00308 |
Nectin-4 Protein, Human, Recombinant (His & Avi)
PVRL4,LNIR,NECTIN4,PRR4,EDSS1 |
Human | HEK293 Cells |
Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus. Nectin-4 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 37.2 kDa and the accession number is Q96NY8. | |||
TMPH-02933 |
Thrombospondin-2/THBS2 Protein, Mouse, Recombinant (His)
Thrombospondin-2,Thbs2 |
Mouse | P. pastoris (Yeast) |
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. Thrombospondin-2/THBS2 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.1 kDa and the accession number is Q03350. | |||
TMPK-00309 |
Nectin-4 Protein IgV Domain, Human, Recombinant (His & Avi)
PRR4,PVRL4,LNIR,NECTIN4,EDSS1 |
Human | HEK293 Cells |
Nectin-4 seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.(Microbial infection) Acts as a receptor for measles virus. Nectin-4 Protein IgV Domain, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 15.8 kDa and the accession number is Q96NY8-1. | |||
TMPH-02265 |
TNFAIP6 Protein, Human, Recombinant (His)
Hyaluronate-binding protein,TNF-stimulated gene 6 protein,Tu... |
Human | E. coli |
Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. TNFAIP6 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33.1 kDa and the accession number is P98066. | |||
TMPY-03395 |
PC4/SUB1 Protein, Human, Recombinant (His)
PC4,RPO2TC1,SUB1 homolog, transcriptional regulator,p14,SUB1... |
Human | E. coli |
SUB1 belongs to the transcriptional coactivator PC4 family. It is a general coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. SUB1 binds single-stranded DNA. Single-stranded DNA-binding proteins play many roles in nucleic acid metabolism, but their importance during transcription remains unclear. SUB1 exhibits strong genetic interactions with factors necessary for promoter melting. It loc... | |||
TMPH-02812 |
Nidogen-1 Protein, Mouse, Recombinant (His)
Nid1,Nidogen-1,Entactin |
Mouse | P. pastoris (Yeast) |
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. | |||
TMPH-03094 |
Phl p 5b Protein, Phleum pratense, Recombinant (His & SUMO)
Pollen allergen Phl p 5b,Allergen Phl p Vb |
Phleum pratense | E. coli |
Has ribonuclease activity. May be involved in host-pathogen interactions. Phl p 5b Protein, Phleum pratense, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 42.1 kDa and the accession number is Q40963. | |||
TMPH-00649 |
LptA Protein, E. coli, Recombinant (His & SUMO)
lptA,Lipopolysaccharide export system protein LptA |
E. coli | E. coli |
Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. | |||
TMPJ-01441 |
OX40L/TNFSF4 Protein, Cynomolgus, Recombinant (His)
OX-40L,TNFSF4,Tumor necrosis factor ligand 2B |
Cynomolgus | HEK293 Cells |
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein. OX40L is expressed by DCs, macrophages and B cells and signals via its cognate receptor OX40 which is mainly expressed on APCs. OX40L/OX40 interactions are important in T-cell activation and survival and for the generation of memory T cells from activated effector T cells. It is a cytokine that binds to TNFRSF4, Co-stimulates T-cell proliferation and cytokine production. OX40L/OX40 interact... | |||
TMPK-00514 |
IL-18RAP Protein, Cynomolgus, Recombinant (His)
IL-18RAcP,IL-1R7,IL-18R-β,IL-18Rbeta,IL18RAP,IL18RB,IL-1R-7,... |
Cynomolgus | HEK293 Cells |
IL-18RAP, also known as IL-18Rβ or IL-1R7, is component of IL-18 receptor complex and its interactions with IL-18R1 mediate signal transduction initiated by IL-18 although it does not directly bind IL-18 in vitro. | |||
TMPH-02934 |
Thrombospondin-3/THBS3 Protein, Mouse, Recombinant (GST)
Thrombospondin-3,Thbs3 |
Mouse | E. coli |
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen. Thrombospondin-3/THBS3 Protein, Mouse, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 62.7 kDa and the accession number is Q05895. | |||
TMPH-02932 |
Thrombospondin-2/THBS2 Protein, Mouse, Recombinant (E. coli, His)
Thrombospondin-2,Thbs2 |
Mouse | E. coli |
Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. Thrombospondin-2/THBS2 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.1 kDa and the accession number is Q03350. | |||
TMPH-03613 |
NblA Protein, Synechococcus elongatus, Recombinant (His & Myc)
nblA,Phycobilisome degradation protein NblA |
Synechococcus elongatus | E. coli |
Involved in phycobilisome (PBS) degradation during nutrient deprivation. May mark the PBS for degradation by covalent association with PBS components or may disrupt the PBS via ionic interactions. NblA Protein, Synechococcus elongatus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.5 kDa and the accession number is P35087. | |||
TMPJ-00339 |
ALCAM Protein, Mouse, Recombinant (hFc)
CD6 ligand,CD166 antigen,CD6L,activated leucocyte cell adhes... |
Mouse | HEK293 Cells |
Activated leukocyte cell adhesion molecule (ALCAM), also named as CD166 and MEMD, is a typeI transmembrane glycoprotein of immunoglobulin superfamily, which mediates homotypic and heterotypic interactions between cells. ALCAM interacts with high affinity with CD6 molecule but weaker homotypic (ALCAM–ALCAM) interactions have also been described. ALCAM–CD6 interactions play an important role in the maintenance of T cell activation, proliferation as well as in formation of immune synapse between an... | |||
TMPK-00255 |
CD209/DC-SIGN Protein, Human, Recombinant (His)
CD209,DC-SIGN,CLEC4L,CD209 molecule,DC-SIGN1,MGC129965,CDSIG... |
Human | HEK293 Cells |
C-type lectin CD209/DC-SIGN and CD209L/L-SIGN proteins are distinct cell adhesion and pathogen recognition receptors that mediate cellular interactions and recognize a wide range of pathogens, including viruses such as SARS, SARS-CoV-2, bacteria, fungi and parasites. Pathogens exploit CD209 family proteins to promote infection and evade the immune recognition system. | |||
TMPY-05321 |
CYP3A4 Protein, Human, Recombinant (His)
P450C3,P450PCN1,CYPIIIA4,CP34,cytochrome P450 family 3 subfa... |
Human | E. coli |
CYP3A4 is an important member of the cytochrome P450 enzyme superfamily, with 33 allelic variants. Human cytochrome P450 3A4 (CYP3A4) is an important drug metabolizing enzyme involved in a number of drug-drug and food-drug interactions. Systemic inflammation has been linked to suppressed CYP3A4 activity. | |||
TMPJ-00426 |
Siglec-5 Protein, Cynomolgus, Recombinant (His)
Sialic acid-binding Ig-like lectin 5,Siglec-5 |
Cynomolgus | HEK293 Cells |
Sialic acid-binding Ig-like lectin 5 is a protein that in Cynomolgus is encoded by the SIGLEC5 gene, Cynomolgus SIGLEC5 cDNA encodes 551 amino acids (aa) that include a 16 aa signal sequence, a 439aa extracellular domain (ECD) with three Ig-like domains, a transmembrane region and a cytoplasma tail. No Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biologic... | |||
TMPH-02188 |
Tenascin-X Protein, Human, Recombinant (His & Myc)
TNXB,Tenascin-X,Hexabrachion-like protein |
Human | E. coli |
Appears to mediate interactions between cells and the extracellular matrix. Substrate-adhesion molecule that appears to inhibit cell migration. Accelerates collagen fibril formation. May play a role in supporting the growth of epithelial tumors. Tenascin-X Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 81.5 kDa and the accession number is P22105. | |||
TMPH-01221 |
GLCE Protein, Human, Recombinant (His)
Heparosan-N-sulfate-glucuronate 5-epimerase,D-glucuronyl C5-... |
Human | E. coli |
Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. GLCE Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 70.9 kDa and the accession number is O94923. | |||
TMPH-02813 |
Nidogen-1 Protein, Mouse, Recombinant (E. coli, His)
Nid1,Nidogen-1,Entactin |
Mouse | E. coli |
Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions. Nidogen-1 Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 30.3 kDa and the accession number is P10493. | |||
TMPK-00352 |
Siglec-4a/MAG Protein, Human, Recombinant (His & Avi), Biotinylated
S-MAG,MAG,GMA,Siglec-4a,Siglec4a |
Human | HEK293 Cells |
Siglec-4a, also known as Myelin-Associated Glycoprotein (MAG), is a type I transmembrane glycoprotein belonging to the Siglec family, a subgroup of the Ig superfamily. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). | |||
TMPJ-01055 |
HBA1 Protein, Human, Recombinant (His)
α-globin,Hemoglobin subunit alpha,HBH,HBA-T3,Alpha-globin,He... |
Human | E. coli |
Hemoglobin subunit alpha 1 (HBA1), also known as α2β2, is a hetero-tetramer consisting of two α and two β subunits held together by non-covalent interactions. Each subunit contains a heme group with an iron atom in the Fe2+ state. Cooperativity of Hemoglobin (Hb) in binding with O2 and allosteric regulatory binding properties with CO2, H+, Cl−, and 2,3-DPG (2,3-bisphosphoglycerate) are based on subunit interactions. HBA1 is the most common type of Hb in adult humans, which mediates the transport... | |||
TMPH-03252 |
BCAN Protein, Rat, Recombinant (hFc)
Bcan,Behab,BEHAB,Brevican core protein,Brain-enriched hyalur... |
Rat | HEK293 Cells |
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Isoform 2 may function as a chondroitin sulfate-bearing cell surface receptor. BCAN Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFC tag. The predicted molecular weight is 44 kDa and the accession number is P55068. | |||
TMPH-02709 |
SAP130 Protein, Mouse, Recombinant (His)
Sap130,130 kDa Sin3-associated polypeptide,Sin3-associated p... |
Mouse | E. coli |
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. SAP130 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.8 kDa and the accession number is Q8BIH0. | |||
TMPH-01984 |
CLECL1P Protein, Human, Recombinant (His & Myc)
Putative C-type lectin-like domain family 1,DC-associated le... |
Human | Baculovirus Insect Cells |
May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response. CLECL1P Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 13 kDa and the accession number is Q8IZS7. | |||
TMPJ-00273 |
IGSF11 Protein, Human, Recombinant (hFc)
CXADRL1,BT-IgSF,CT119,Igsf13,VSIG3 |
Human | HEK293 Cells |
Immunoglobulin superfamily member 11(IGSF11) is abundantly expressed in testis and ovary and to a lower extent in brain, kidney and skeletal muscle.IGSF11 functions as a cell adhesion molecule through homophilic interaction and can also stimulates cell growth.IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. | |||
TMPH-03253 |
BCAN Protein, Rat, Recombinant (His & Myc)
Brevican core protein,Behab,Bcan,Brain-enriched hyaluronan-b... |
Rat | Baculovirus Insect Cells |
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Isoform 2 may function as a chondroitin sulfate-bearing cell surface receptor. BCAN Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 19 kDa and the accession number is P55068. | |||
TMPK-00830 |
P-Selectin Protein, Human, Recombinant (Avi & His), Biotinylated
FLJ45155,CD62P,GRMP,CD62,P-Selectin,PSEL,GMP140,LECAM3,SELP,... |
Human | HEK293 Cells |
Human P-Selectin (GMP-140, LECAM-3, PADGEM, CD62P), a member of the Selectin family, is a cell surface glycoprotein expressed by activated platelets and endothelial cells. A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. | |||
TMPH-00249 |
Bovine coronavirus (strain Quebec) Nucleoprotein/NP Protein (His)
N,NC,Nucleoprotein,Nucleocapsid protein,Protein N |
BCoV | E. coli |
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Bovine coronavirus (strain Quebec) Nucleoprotein/NP Protein (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 50.3 kDa and ... | |||
TMPH-00250 |
Bovine coronavirus (strain F15) Nucleoprotein/NP Protein (His)
Nucleoprotein,Nucleocapsid protein,Protein N,N,NC |
BCoV | HEK293 Cells |
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Bovine coronavirus (strain F15) Nucleoprotein/NP Protein (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 51.7 kDa and the ac... | |||
TMPH-00140 |
IBV (strain V18/91) Nucleoprotein/NP Protein (His)
N,Nucleocapsid protein,Nucleoprotein |
IBV | HEK293 Cells |
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. IBV (strain V18/91) Nucleoprotein/NP Protein (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 48 kDa and the accession number... | |||
TMPH-00136 |
IBV (strain Beaudette CK) Nucleoprotein/NP Protein (His)
N,Nucleocapsid protein,Nucleoprotein |
IBV | HEK293 Cells |
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. IBV (strain Beaudette CK) Nucleoprotein/NP Protein (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 47.2 kDa and the accessio... | |||
TMPH-00141 |
IBV (strain D1466) Nucleoprotein/NP Protein (His)
N,Nucleoprotein,Nucleocapsid protein |
IBV | E. coli |
Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. IBV (strain D1466) Nucleoprotein/NP Protein (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 46.1 kDa and the accession nu... | |||
TMPH-01798 |
Nucleolar transcription factor 1 Protein, Human, Recombinant (Cell-Free, His & SUMO)
Nucleolar transcription factor 1,Upstream-binding factor 1,U... |
Human | E. coli |
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. Nucleolar transcription factor 1 Protein, Human, Recombinant (Cell-Free, His & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO tag. The predicted molecular weight is 107.9 kDa and the accession number is P17480. | |||
TMPH-03587 |
GspB Protein, S. gordonii, Recombinant (GST)
Serine-rich adhesin for platelets,Serine-rich repeat protein... |
Streptococcus gordonii | E. coli |
Plays a role in virulence and host-pathogen interactions. Mediates binding to human platelets via interaction with the human cell surface glycoprotein GP1BA. Plays a positive role in biofilm formation, possibly by self-association via the basic region (BR). GspB Protein, S. gordonii, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.5 kDa and the accession number is Q939N5. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T35790 |
Palmitic acid-1,2,3,4-13C4
Palmitic Acid-13C (C1, C2, C3, and C4 labeled) |
||
Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula... |