MAIT-203, a cyclopentyalanin-derived peptidomimetic, effectively disrupts the interaction between adenomatous polyposis coli (APC) and Asef (RhoGEF4), without affecting APC-Sam68 or APC-striatin interactions. It binds to APC-ARM domains with a K i of 0.015 μM and a K d of 0.036 μM, and notably inhibits the migration and invasion of colorectal cancer cells.

MAIT-203 (10 μM与25 μM；作用24小时) 在HEK293T细胞中通过剂量依赖方式降低了Asef-APC的相互作用 [1]。