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Cyclo(RGDfC) TFA (Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA) 是一种环状五肽,对 αvβ3 具有高亲和力的环状 RGD 多肽,能够破坏细胞整合素相互作用。Cyclo(RGDfC) TFA 抑制胚胎干细胞 (ESC) 的多能性基因表达,并在体内抑制 mESC 的致瘤潜力。Cyclo(RGDfC) TFA 可用于肿瘤相关的研究。
Cyclo(RGDfC) TFA (Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA) 是一种环状五肽,对 αvβ3 具有高亲和力的环状 RGD 多肽,能够破坏细胞整合素相互作用。Cyclo(RGDfC) TFA 抑制胚胎干细胞 (ESC) 的多能性基因表达,并在体内抑制 mESC 的致瘤潜力。Cyclo(RGDfC) TFA 可用于肿瘤相关的研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 268 | 期货 | |
5 mg | 询价 | 现货 |
产品描述 | Cyclo(RGDfC) TFA (Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA) is a cyclic pentapeptide, a cyclic RGD polypeptide with high affinity for αvβ3, which is capable of disrupting cellular integrin interactions. Cyclo(RGDfC) TFA inhibits pluripotent gene expression in embryonic stem cells (ESCs) and inhibits tumorigenic potential of mESCs in vivo. Cyclo(RGDfC) TFA inhibits the tumorigenic potential of mESC. Cyclo(RGDfC) TFA can be used for tumor-related studies. |
体外活性 | 0.5 mM Cyclo(RGDfC) TFA,处理24小时能够下调mESC中的转录因子Oct 4、Sox 2和Nanog的表达,并抑制mESC-col I(I型胶原蛋白)构建中的整合素基因表达。此外,处理后的mESC细胞会形成团聚体并从表面脱离。[1] |
体内活性 | 0.5 mM Cyclo(RGDfC) TFA,处理24小时,处理的mESC在有或没有白血病抑制因子(LIF)的条件下(通过双腿注射),抑制了严重联合免疫缺陷(SCID)小鼠的畸胎瘤形成。[1] |
别名 | Cyclo(RGDfC) 三氟乙酸盐, Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA |
分子量 | 692.67 |
分子式 | C26H35F3N8O9S |
Smiles | O=C([C@@H](NC(CNC([C@@H](NC([C@@H](NC1=O)CS)=O)CCCNC(N)=N)=O)=O)CC(O)=O)N[C@@H]1CC2=CC=CC=C2.OC(C(F)(F)F)=O |
存储 | keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | H2O: 10 mg/mL (14.44 mM), Sonication is recommended. | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
H2O
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