购物车
- 全部删除
- 您的购物车当前为空
Amyloid-Forming peptide GNNQQNY是由酵母蛋白Sup35的N-末端朊病毒决定结构域中得来的七肽段,具有生物活性,并能形成淀粉样纤维。它的详细原子低聚结构之研究,使其成为揭示早期聚集阶段的理想模型。GNNQQNY二聚体以三种稳定构形存在:寄存器内并排、寄存器外并排和反向并排。对准的平行二聚体其β-pleated sheet结构中肽链间氢键较少,强调了疏水作用的重要性,相较于反向并排结构有更高的构象熵。
Amyloid-Forming peptide GNNQQNY是由酵母蛋白Sup35的N-末端朊病毒决定结构域中得来的七肽段,具有生物活性,并能形成淀粉样纤维。它的详细原子低聚结构之研究,使其成为揭示早期聚集阶段的理想模型。GNNQQNY二聚体以三种稳定构形存在:寄存器内并排、寄存器外并排和反向并排。对准的平行二聚体其β-pleated sheet结构中肽链间氢键较少,强调了疏水作用的重要性,相较于反向并排结构有更高的构象熵。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | Amyloid-Forming peptide GNNQQNY, a biologically active heptapeptide derived from the N-terminal prion-determining domain of yeast Sup35, is instrumental in amyloid fibril formation. Its atomic oligomeric structure has been detailed, serving as an excellent model for investigating early-stage aggregation. The peptide can form three stable β-sheet structures: in-register parallel, off-register parallel, and anti-parallel. Notably, the in-register parallel dimer aligns closely with amyloid β-sheet architecture, relying on fewer interpeptide hydrogen bonds and emphasizing hydrophobic interactions, which enhances conformational entropy relative to the anti-parallel arrangement. |
分子量 | 836.81 |
分子式 | C33H48N12O14 |
CAS No. | 339091-39-3 |
存储 | keep away from moisture | Shipping with blue ice. |
版权所有©2015-2024 TargetMol Chemicals Inc.保留所有权利.
评论内容