312
67
4
53
6
Cat. No. | Product Name | ||
---|---|---|---|
L1720 | 核苷类化合物库 | 334 compounds | |
334 种核苷类化合物,包括核苷酸、核苷酸类似物及衍生物等,适用于抗病毒、抗肿瘤、抗真菌、抗抑郁等药物的研发; | |||
L2193 | 抗肝癌化合物库 | 1787 compounds | |
1787 种与肝癌相关的化合物,可以用于抗肝癌药物研发和药理研究; | |||
L1100 | 蛋白酶抑制剂库 | 343 compounds | |
343 种已知的小分子蛋白酶抑制剂的特有集合,可用于高通量筛选和高内涵筛选; | |||
L6730 | 抗病毒中药单体化合物库 | 268 compounds | |
268 种具有抗病毒活性的中药单体集合,是药物开发、药理研究的有效工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1520 |
Hepatitis B Virus Core (128-140)
Hepatitis B Virus Core 128-140 |
||
The hepatitis B virus (HBV) core protein has been found in the nucleus, the cytoplasm, or both of HBV-infected hepatocytes. nuclear localization of the HBV core protein is negatively regulated by phosphorylation during the cell cycle. | |||
T39503 |
Hepatitis Virus C NS3 Protease Inhibitor 2
|
||
Hepatitis Virus C NS3 Protease Inhibitor 2 is a peptide inhibitor derived from a product that targets the NS3 protease of the hepatitis C virus (HCV). Its inhibitory activity against the NS3 protease is characterized by a Ki value of 41 nM. | |||
TP2231 |
HBcAg [Hepatitis B virus] (18-27)
|
Others | Others |
HBcAg (core antigen) is a hepatitis B viral protein. It is an indicator of active viral replication; this means the person infected with Hepatitis B can likely transmit the virus on to another person. | |||
T23407 |
surface antigen (208-215) [Hepatitis B Virus]
|
Others | Others |
The nucleocapsid of the hepatitis B virus is covered by an envelope of HBV surface antigen (HBsAg), which has the common, group-specific determinant a. The four major subtypes of HBsAg, adw, adr, ayw and ayr, are generated, and they have been proposed to | |||
T76524 |
Hepatitis C Virus S5A/5B
|
||
Hepatitis C Virus S5A/5B是一种合成肽底物,模拟非结构蛋白(NS)的NS5A/5B连接,用于研究HCVNS3蛋白酶活性。 | |||
T76527 |
Hepatitis B Virus Receptor Binding Fragment
|
||
Hepatitis B Virus Receptor Binding Fragment(hepatitis B peptide 4980)为一合成肽类似物,特异性结合Hep G2细胞。基于病毒中和粘附阻断理念,此Fragment可望激发保护性抗体生成,展现作为免疫原的巨大潜力。 | |||
T16366 |
NVR 3-778
|
HBV | Microbiology/Virology |
NVR 3-778 是一种 SBA 类的口服有效HBV CAM 衣壳组装调制剂,具有抗 HBV 活性。 | |||
T11669 |
IR415
|
HBV | Microbiology/Virology |
IR415 选择性地与 HBx 相互作用 (Kd=2 nM) 并阻断 HBV 介导的 RNAi 抑制,逆转 HBx 蛋白对 Dicer 核糖核酸内切酶活性的抑制作用。IR415 具有抗 HBV 的活性。 | |||
T27527 |
HBF-0259
HBF 0259 |
Antiviral | Immunology/Inflammation |
HBF-0259 是有效的乙型肝炎病毒 表面抗原分泌选择性抑制剂,在 HepG2.2.15 细胞中的 EC50为 1.5 μM。 | |||
T17190 |
U18666A
|
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
U18666A 是一种细胞渗透性药物,是一种胆固醇合成和转运抑制剂,抑制埃博拉病毒,登革热病毒和人类丙型肝炎病毒的复制。 | |||
T5938 |
4-Phenoxybenzylamine
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
4-Phenoxybenzylamine 通过稳定无活性构象来抑制NS3蛋白的功能,对 HCV NS3/4a 的 IC50 约为 500 μM。 | |||
T76528 |
Hepatitis b virus pre-s region (120-145)
|
||
Hepatitis b virus pre-s region (120-145) 是一种 preS2 肽,可抑制单链 Fv 片段 (scFv) 或IgG 与 r-HBsAg 的结合。 | |||
T5832 |
Besifovir
|
HBV | Microbiology/Virology |
Besifovir 是由 LB80380 转化而来的一种 LB80380 母体药物,进一步代谢为其活性形式 LB80317。LB80380 是抗乙型肝炎病毒的抗病毒药物。 | |||
T83511 |
[Ala127] Hepatitis B Virus Pre-S Region (120-131)
|
||
[Ala127] Hepatitis B Virus Pre-S Region (120-131) 是一种肽,序列为MQWNSTAFHQT。该肽适用于活性增强的研究。 | |||
T15573 |
Inarigivir soproxil
SB9200 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Inarigivir soproxil (SB9200) 是一种先天免疫激动剂。 它还显示出针对耐药丙型肝炎病毒 (HCV) 变体的有效抗病毒活性。在基因型 1 HCV 复制子系统细胞中, HCV 1a/1b 的 EC50 为 2.2 和 1.0 μM。 | |||
T20048 |
Vidarabine phosphate
|
Antiviral | Immunology/Inflammation |
Vidarabine phosphate 是一种单磷酸腺苷类似物。它是 VIDARABINE 的单磷酸酯。它还具有抗病毒和可能的抗肿瘤特性。 | |||
T9577 |
HCV-IN-31
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
HCV-IN-31 是一种HCV 抑制剂,EC50/EC95值为15.7 μM。 | |||
T6846 |
Vesatolimod
GS-9620,维沙莫德 |
Apoptosis; HCV Protease; HBV; TLR; HIV Protease | Apoptosis; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Vesatolimod (GS-9620) 是一种选择性 Toll 样受体 7 口服激动剂,EC50值为291 nM。 | |||
T4475 |
JNJ-632
|
HBV | Microbiology/Virology |
JNJ-632 是一种乙型肝炎病毒衣壳组装调节剂。 | |||
T25268L |
Coblopasvir dihydrochloride
Coblopasvir dihydrochloride(1312608-46-0 Free base) |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Coblopasvir dihydrochloride 是一种泛基因型非结构蛋白 5A(NS5A)抑制剂。本品可用于慢性丙型肝炎病毒感染的研究。 | |||
T3444 |
Merimepodib
美泊地布,VX-497,VI-21497 |
Dehydrogenase; Antiviral; HCV Protease; HBV | Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Merimepodib (VX-497) 是一种新型非竞争性肌苷一磷酸脱氢酶抑制剂,具有广谱抗病毒活性。 | |||
TQ0017 |
AB-423
|
HBV | Microbiology/Virology |
AB-423 是一种 HBV 衣壳组装抑制剂,抑制 HBV 复制。在细胞中,EC50/EC90值分别为 0.08-0.27 μM/0.33-1.32 μM。 | |||
T16088 |
MK-0608
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
MK-0608 是一种可口服的体外 HCV 复制抑制剂。在亚基因组复制子测定中,EC50值为 0.3 μM,EC90值为 1.3 μM。 | |||
T11409 |
GLP-26
|
HBV | Microbiology/Virology |
GLP-26 是一种HBV 衣壳组装调节剂,抑制 Hep AD38 系统中的 HBV DNA 复制,IC50值为3 nM。 在 1 μM 时,使 cccDNA 降低> 90%。它破坏前基因组 RNA 的衣壳化,导致核衣壳解体,并减少 cccDNA 库。 | |||
T11539 |
HCV-IN-29
|
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
HCV-IN-29 是一种丙型肝炎病毒抑制剂。 | |||
T11541 |
HCV-IN-30
|
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
HCV-IN-30 是 HCV NS5A 复制复合物的抑制剂(基因型 1a 和 1b 复制子的 IC50 = 901 和 102 nM)。 | |||
T4544 |
Elbasvir
MK-8742 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Elbasvir (MK-8742) 是丙型肝炎病毒的非结构蛋白 5A 抑制剂,可用于治疗慢性 HCV 感染。 | |||
T38237 |
2′-O-Methylcytidine
|
Nucleoside Antimetabolite/Analog; HCV Protease | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome |
2'-O-Methylcytidine 是 2'-代核苷,可抑制 HCV 复制。 它在体外抑制 NS5B 催化的 RNA 合成,其抑制方式是与底物核苷三磷酸竞争。 | |||
T3449 |
Bay 41-4109 racemate
|
HBV | Microbiology/Virology |
BAY 41-4109 racemate 是BAY 41-4109的消旋体。BAY 41-4109有效抑制人乙型肝炎病毒,IC50值为53 nM。 | |||
T0013 |
Mecarbinate
优多降,Dimecarbine,Dimecarbin,美卡比酯 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Mecarbinate 是一种吲哚衍生物,具有抗 HCV 活性和免疫调节作用。 | |||
T1565 |
Deferiprone
去铁酮,Deferidone,CP20 |
Others; HCV Protease; Ferroptosis; UGT | Apoptosis; Metabolism; Microbiology/Virology; Others; Proteases/Proteasome |
Deferiprone (Deferidone) 是口服活性铁螯合剂,可研究地中海贫血中的输血性铁过载。 | |||
T9225 |
Vebicorvir
ABI-H0731 |
HBV | Microbiology/Virology |
Vebicorvir (ABI-H0731) 是一种乙型肝炎病毒核心蛋白的抑制剂,有抗病毒活性。 | |||
T7447 |
Adefovir
|
HBV; Reverse Transcriptase; Telomerase | DNA Damage/DNA Repair; Microbiology/Virology |
Adefovir 是一种单磷酸腺苷类似物抗病毒剂,在细胞内转化为 Adefovir diphosphate 后可抑制HBVDNA 聚合酶。它在 HepG2.2.15 细胞系中对HBV 的IC50为 0.7 μM。它对多种病毒(包括HBV 和疱疹病毒)具有良好的抗病毒活性。 | |||
T0044 |
Oxethazaine
奥昔卡因,Oxetacaine |
HBV; Sodium Channel | Membrane transporter/Ion channel; Microbiology/Virology |
Oxethazaine (Oxetacaine) 是一种具有耐酸性和口服活性试剂,是芬特明的酸性前体,有潜力缓解消化性溃疡疾病或食管炎引起的疼痛。 | |||
T4121 |
Bicyclol
SY801,双环醇 |
HBV; Autophagy | Autophagy; Microbiology/Virology |
Bicyclol (SY801) 是一种抗肝炎 HBV 和 HCV 药物。 | |||
T12097 |
Morphothiadin
GLS4,莫非赛定 |
HBV | Microbiology/Virology |
Morphothiadin (GLS4) 是一种有效的抑制野生型和阿德福韦耐药 HBV 复制的抑制剂,IC50值为 12 nM。 | |||
T0353 |
Osalmid
Oxaphenamide,4'-Hydroxysalicylanilide,羟苯水杨胺,柳胺酚 |
HBV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Osalmid (Oxaphenamide) 是一种利胆药物,通过靶向核糖核苷酸还原酶小亚基 M2 来抑制核糖核苷酸还原酶的活性,IC50值为8.23 μM。 | |||
T7158 |
Ombitasvir
奥比他韦,ABT-267 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Ombitasvir (ABT-267) 是丙型肝炎病毒非结构蛋白 5A 的口服生物可利用的强效抑制剂。对 HCV 基因型 1 至 5 的 EC50 为 0.82 至 19.3 pM,对基因型 6a 的 EC50 为 366 pM。 | |||
T1822 |
Clemizole
克立咪唑,吡咯咪唑 |
HCV Protease; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Clemizole 是一种 H1 组胺受体拮抗剂,可抑制 NS4B 的 RNA 结合和丙型肝炎病毒复制。它也是TRP5通道抑制剂。 | |||
T5126 |
Glecaprevir
ABT-493 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Glecaprevir (ABT-493) 是一种新型的 HCV NS3/4A 蛋白酶抑制剂,其 IC50值在 3.5 和 11.3 nM 之间。它也是 SARS-CoV 3CLpro 的抑制剂,IC50为 4.09 μM。 | |||
T1513 |
Telbivudine
NV 02B,L-Thymidine,Epavudine,替比夫定 |
Others; HBV; Reverse Transcriptase | Microbiology/Virology; Others |
Telbivudine (NV 02B) 是一种乙型肝炎病毒复制的抗病毒抑制剂,是一种具有口服活性的胸腺嘧啶核苷类似物。 | |||
T4547 |
Grazoprevir
MK-5172 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Grazoprevir (MK-5172) 是一种丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂,具有跨基因型和耐药变体的广泛活性,对 gt1b、gt1a、gt2a、gt2b 和 gt3a 的Ki 分别为 0.01 nM、0.01 nM、0.08 nM、0.15 nM 和 0.90 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。 | |||
T9341 |
Bemnifosbuvir
AT-511 |
Others; HCV Protease; SARS-CoV | Microbiology/Virology; Others; Proteases/Proteasome |
Bemnifosbuvir (AT-511) 是一种口服活性抑制剂,抑制 HCV 病毒复制,具有全基因型抗病毒活性。它有效抑制 SARS-CoV-2 (COVID-19)感染 (EC90=0.47 μM)。 | |||
T6200 |
Ledipasvir
GS-5885,雷迪帕韦 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Ledipasvir (GS-5885) 是一种丙型肝炎病毒 NS5A 抑制剂。它也是 P-糖蛋白抑制剂和乳腺癌抗性蛋白抑制剂。 | |||
T14489 |
Azvudine
4-氨基-1-(4-C-叠氮基-2-脱氧-2-氟-BETA-D-呋喃阿拉伯糖基)-2(1H)-嘧啶酮,FNC,RO-0622 |
HCV Protease; HBV; HIV Protease; Reverse Transcriptase | Microbiology/Virology; Proteases/Proteasome |
Azvudine (FNC) 是一种有效的核苷逆转录酶抑制剂 (NRTI),对 HIV、HBV 和 HCV 具有抗病毒活性。它抑制耐 NRTI 的病毒株,高效抑制 HIV-1和 HIV-2。 | |||
T11760 |
KIN101
3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene,3-(4-溴苯基)-4-氧代-7-[(甲磺酰基)氧基]-4H-色烯 |
HCV Protease; Influenza Virus; RSV; Antifection | Microbiology/Virology; Proteases/Proteasome |
KIN101 (3-(4-Bromophenyl)-7-[(methylsulfonyl)oxy]-4-oxo-4H-chromene) 是 IRF-3 依赖性信号传导的异黄酮激动剂,可诱导 IRF-3 核易位。 它对 RNA 病毒、HCV 和 RSV 具有抗病毒活性。 | |||
T3334 |
Velpatasvir
GS-5816,维帕他韦 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Velpatasvir (GS-5816) 是一种的 HCV NS5A 抑制剂。它也是 SARS-CoV 3CLpro 的抑制剂,IC50为 2.16 μM。 | |||
T26674 |
AT-130
AT 130 |
HBV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
AT-130 是一种苯基丙烯酰胺衍生物,是乙型肝炎病毒复制的非核苷抑制剂。它抑制病毒 DNA 的合成,EC50为 0.13 μM。 | |||
T12719 |
RG7834
RO 7020322 |
HBV | Microbiology/Virology |
RG7834 (RO 7020322) 是一种高度选择性 HBV 口服抑制剂,在 dHepaRG 细胞中,可抑制 HBV 抗原 HBeAg、HBsAg 和 HBV DNA,IC50值分别为 2.6、2.8 和 3.2 nM。 | |||
T22142 |
RO8191
RO4948191,CDM-3008 |
HCV Protease; HBV; JAK; IFNAR; STAT | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells |
RO8191 (CDM-3008) 是干扰素 (IFN) 受体激动剂。它直接与 IFNα/β 受体 2 结合,激活 IFN 刺激的基因表达和 JAK/STAT 磷酸化。它通过具有干扰素样活性发挥 cccDNA 调节剂作用,并具有抗 HBV 活性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4S1718 |
Punicalin
|
HBV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Punicalin 是从Punica granatumL. 或Terminalia catappaL. 的叶子中分离的,一种可水解的单宁,具有抗炎活性。它是一种抗乙型肝炎病毒药物。 | |||
TN1482 |
Chamaechromone
|
P450; HBV | Metabolism; Microbiology/Virology |
Chamaechromone 是从 Stellera chamaejasme L. 的根中分离出来的天然产物。 Chamaechromone 具有抗 HBV 和杀虫活性。 | |||
T3273 |
Bifendate
联苯双酯,Bifendatatum |
HBV; Reverse Transcriptase | Microbiology/Virology |
Bifendate (Bifendatatum) 是 Schisandrin C 的合成中间体,在慢性 B 型肝炎的研究中具有抗HBV 功效,用于治疗病毒性肝炎和药物性肝损伤引起的转氨酶升高。 | |||
T2780 |
Catalpol
梓醇,Catalpinoside,Digitalis purpurea L |
Others; HBV | Microbiology/Virology; Others |
Catalpol (Catalpinoside) 是一种在Rehmannia glutinosa 中发现的鸢尾花苷,具有神经保护、降血糖、抗癌、抗痉挛、抗氧化、抗HBV 和抗肝炎病毒作用。 | |||
T3S0872 |
Paederoside
|
Antiviral; HBV | Immunology/Inflammation; Microbiology/Virology |
Paederoside 是从Paederia pertomentosa 分离的一种单萜 S-甲基硫代碳酸酯。它抑制 Epstein-Barr 病毒的激活,有抗肿瘤促进作用。 | |||
T5S1598 |
Mulberroside C
桑皮苷 C,桑皮苷C |
Antioxidant; HCV Protease | Microbiology/Virology; oxidation-reduction; Proteases/Proteasome |
Mulberroside C 是桑树中的主要生物活性成分之一,可抑制 HCV 复制,具有抗病毒活性。 | |||
T3750 |
4-Hydroxyacetophenone
对羟基苯乙酮,4-Acetylphenol,Piceol,p-Acetylphenol,4'-Hydroxyacetophenone |
HBV; Xanthine Oxidase | Metabolism; Microbiology/Virology |
4-Hydroxyacetophenone (4-Acetylphenol) 是蒿属植物和木香属植物中的一种黄嘌呤氧化酶抑制剂,具有保肝促胆、抗乙型肝炎病毒和抗炎作用。 | |||
TQ0248 |
Alisol F
泽泻醇 F,泽泻醇F |
HBV | Microbiology/Virology |
Alisol F 是从泽泻中分离得到的一种三萜,具有免疫抑制和抗病毒功能。 | |||
T2770 |
Gentiopicroside
Gentiopicrin,龙胆苦甙,龙胆苦苷 |
P450; HCV Protease | Metabolism; Microbiology/Virology; Proteases/Proteasome |
Gentiopicroside (Gentiopicrin) 是天然环烯醚萜苷,具有抗炎和抗氧化活性。它抑制P450的活性,对 CYP2A6 的 IC50和 Ki 值分别为 61 µM 和 22.8 µM, | |||
TN2089 |
Platycodin D3
桔梗皂苷D3,桔梗皂苷 D3 |
HCV Protease; NF-κB | Microbiology/Virology; NF-κB; Proteases/Proteasome |
Platycodin D3 是桔梗中有抗HCV 活性的一种三萜皂苷类天然产物。 | |||
T1922 |
Pseudolaric Acid B
土槿乙酸B,土荆皮乙酸 |
Apoptosis; p38 MAPK; Ferroptosis; HBV; Autophagy; Antifungal | Apoptosis; Autophagy; MAPK; Microbiology/Virology |
Pseudolaric Acid B 是一种从Pseudolarix kaempferiGorden (pinaceae) 根部分离的二萜酸,具有抗癌、抗真菌、抗受精和免疫抑制活性。它还诱导细胞自噬。 | |||
T3810 |
Saikosaponin B2
柴胡皂苷 B2,柴胡皂甙 B2 |
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Saikosaponin B2 是从柴胡根中分离得到的一种活性成分,可抑制 HCV 病毒感染的侵入,有抗癌作用。 | |||
T3921 |
Punicalagin
安石榴甙,安石榴苷 |
SARS-CoV; HBV | Microbiology/Virology |
Punicalagin 是一种在石榴中发现的主要鞣花单宁,是可逆且非竞争性的 3CLpro 抑制剂。Punicalagin 具有抗氧化、抗炎和抗肿瘤活性。 | |||
T5S2254 |
Swertianolin
Bellidifolin-8-O-Glucoside,当药醇苷 |
Others; HBV; Antibacterial; AChE | Microbiology/Virology; Neuroscience; Others |
Swertianolin (Bellidifolin-8-O-Glucoside) 是从Gentianella Acuta 分离得到的一种黄酮,具有抗 HBV 和抗菌活性,可抑制乙酰胆碱酯酶。 | |||
T21936 |
M50054
2,2′-亚甲基双(1,3-环己二酮) |
Caspase | Apoptosis; Proteases/Proteasome |
M50054 是一种有效的细胞凋亡抑制剂,可用于研究抗 Fas 抗体引起的肝炎和化疗引起的脱发。它抑制 Etoposide 诱导的 U937 细胞 caspase-3 活化,IC50为 79 μg/mL。 | |||
T3815 |
Isoscopoletin
异莨菪亭,7-Methoxyesculetin,6-Hydroxy-7-methoxycoumarin |
Others; HBV | Microbiology/Virology; Others |
Isoscopoletin (7-Methoxyesculetin) 是艾叶中的一种活性成分。它具有显著的细胞增殖抑制作用,对人类 CCRF-CEM 白血病细胞和耐药亚系 CEM/ADR5000 作用的 IC50值分别为 4.0 μM 和 1.6 μM。它具有抑制 HBV 复制的活性。 | |||
T2848 |
Osthole
Osthol,NSC 31868,蛇床子素,Ostol |
Apoptosis; HBV; Parasite; Histamine Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Osthole (Osthol) 是一种天然抗组胺药替代试剂,可刺激成骨细胞增殖和分化。它可抑制组胺 H1受体活性,还可抑制细胞培养物中 HBV 的分泌。 | |||
T3001 |
Honokiol
和厚朴酚,NSC 293100 |
ERK; HCV Protease; MEK; Akt; Autophagy | Autophagy; Cytoskeletal Signaling; MAPK; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Honokiol (NSC-293100) 是厚朴提取物的活性成分,靶向多种信号分子,具有抗氧化,抗炎,抗血管生成和抗癌活性。它可抑制 Akt 的激活并增强 ERK1/ERK2 的磷酸化。 | |||
T7607 |
PSI-6130
R 1656,2'-去氧-2'-氟-2'-C-甲基胞苷 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
PSI-6130 (R 1656) 是高效选择性 HCV NS5B 聚合酶抑制剂,抑制 HCV 复制,IC50值为 0.6 μM。 | |||
T5098 |
Isochlorogenic acid A
3,5-CQA,异绿原酸 A,3,5-Dicaffeoylquinic acid,金银花 |
Reactive Oxygen Species; HBV; Endogenous Metabolite | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB |
Isochlorogenic acid A (3,5-Dicaffeoylquinic acid) 是一种天然酚酸,具有抗氧化和抗炎活性。 | |||
T3821 |
Deapioplatycodin D
Deapi-platycodin D,去芹糖桔梗皂苷 D,去芹糖桔梗皂苷D,DesapioplatycodinD |
Others; HCV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
Deapioplatycodin D 是从桔梗中分离出的一种三萜皂苷,具有抗丙型肝炎病毒活性。 | |||
T0392 |
Artemisinin
Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,青蒿素,Artemisinine |
HCV Protease; Ferroptosis; Akt; Parasite | Apoptosis; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Artemisinin (Qinghaosu) 是一种倍半萜烯内酯,是从青蒿植物的地上部分分离的一种抗疟疾药物。它有神经保护和抗癌作用。 | |||
T1188 |
Mizoribine
Bredinin,NSC 289637,咪唑立宾,HE 69 |
HCV Protease; SARS-CoV; Tyrosinase | Microbiology/Virology; Proteases/Proteasome |
Mizoribine (NSC-289637) 是一种免疫抑制剂,抑制HCVRNA 复制,有抗 HCV 活性,IC50约为 100 μM。它抑制SARS-CoV 复制,对 SARS-CoV Frankfurt-1 和 SARS-CoV HKU39849 的 IC50分别为 3.5 μg/mL 和 16 μg/mL。 | |||
T7203 |
Oglufanide
奥谷法奈,L-Glutamyl-L-tryptophan,H-Glu-Trp-OH |
VEGFR; HCV Protease; Endogenous Metabolite | Angiogenesis; Metabolism; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Oglufanide (H-Glu-Trp-OH) 是一种从小牛胸腺中分离出来的二肽免疫调节剂,可抑制血管内皮生长因子,可刺激细胞内细菌感染和对丙型肝炎病毒的免疫反应。 | |||
T2S1158 |
4,5-Dicaffeoylquinic acid
3,4-Dicaffeoylquinic acid,异绿原酸C(4,5),Isochlorogenic acid C |
Others; HBV; Endogenous Metabolite | Metabolism; Microbiology/Virology; Others |
4,5-Dicaffeoylquinic acid (Isochlorogenic acid C) 是一种天然产物,有抗病毒、抗肝毒性活性。 | |||
TN1033 |
Sennidin A
|
HCV Protease; transporter; Akt; PI3K | Cytoskeletal Signaling; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Sennidin A 是从狭叶番泻分离得到的一种天然产物,能够抑制 HCV NS3 解旋酶,其 IC50值为0.8 μM。它诱导 Akt 和葡萄糖转运蛋白4的磷酸化,刺激葡萄糖掺入。 | |||
TN1034 |
Sennidin B
|
HCV Protease; transporter; Akt; PI3K | Cytoskeletal Signaling; Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Sennidin B 是从Cassia angustifolia 分离得到的Sennidin A 异构体,它刺激葡萄糖掺入,诱导Akt 和葡萄糖转运蛋白4 的磷酸化。 | |||
T0894 |
Thiamine hydrochloride
盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺(维生素B1),Thiamine chloride hydrochloride |
Apoptosis; HBV; Endogenous Metabolite | Apoptosis; Metabolism; Microbiology/Virology |
Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素,是许多中枢代谢酶的辅因子。 | |||
T1020 |
Doxorubicin hydrochloride
Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,DOX hydrochloride,盐酸阿霉素,NSC 123127 |
Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素,是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化,还可诱导凋亡和自噬。 | |||
T7060 |
Amantadine
1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine |
Others | Others |
Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 | |||
TN6732 |
Oenothein B
|
Apoptosis; HCV Protease; Antibacterial; Antifungal | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Oenothein B 是一种聚(ADP-核糖)糖水解酶的特异性抑制剂。 Oenothein B 具有抗氧化、抗炎、抗真菌、抗 HCV 和抗肿瘤特性。 | |||
T1456 |
Doxorubicin
Hydroxydaunorubicin,DOX,阿霉素,Adriamycin |
Topoisomerase; AMPK; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling |
Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素,具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II,IC50分别为0.8 μM 和2.67 μM,从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬 。 | |||
T6S1918 |
Schisantherin B
Gomisin-B,Wuweizi ester-B,五味子酯乙,Schizantherin-B |
Beta Amyloid; Others | Neuroscience; Others |
Schisantherin B (Schizantherin-B) 是一种天然产物。 | |||
T9371 |
DL-Pyroglutamic acid
|
Others | Others |
DL-Pyroglutamic acid 对乙型肝炎表面抗原表现出强烈的灭活作用。 | |||
T38375 |
Pseudane IX
2-nonyl-4-hydroxyquinoline,2-nonyl-1H-quinolin-4-one,2-nonyl-4(1h)-quinolone |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Pseudane IX (2-nonyl-1H-quinolin-4-one) 可减少丙型肝炎病毒 (HCV) 对 Huh 7.5 细胞的感染,IC50 为 1.4 μg/ml。 | |||
TN2088 |
Platycodin D2
桔梗皂苷D2 |
IL Receptor; HBV | Immunology/Inflammation; Microbiology/Virology |
Platycodin D2 是分离自桔梗的皂苷类物质,显示除抗癌活性。 | |||
TN1956 |
Mulberrofuran G
|
Phosphatase; HBV; Glucosidase | Metabolism; Microbiology/Virology |
Mulberrofuran G分离自自 Morus alba L.,具有抗乙型肝炎病毒活性,可保护缺血损伤诱导的细胞死亡。Mulberrofuran G 是一种 PTP1B 和 α-葡萄糖苷酶的双重抑制剂,可用于研究阿尔茨海默症。 | |||
TN1543 |
Cynaropicrin
|
HCV Protease; NF-κB; Microtubule Associated | Cytoskeletal Signaling; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Cynaropicrin 是一种存在于朝鲜蓟 (Cynara scolymus) 中倍半萜内酯,具有抗丙型肝炎活性和抗锥虫活性活性,抑制NF-κB活化。 Cynaropicrin 破坏微管蛋白和 c-Myc 相关信号传导,并诱导多发性骨髓瘤中的 parthanatos 型细胞死亡。 | |||
T4A2399 |
Cinobufotalin
华蟾毒它灵,华蟾素 |
IL Receptor; Akt; MRP; P-gp | Cytoskeletal Signaling; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience; PI3K/Akt/mTOR signaling |
Cinobufotalin 是一种从蟾蜍的皮肤分泌物中提取的强心类固醇或丁二烯内酯。它已被用作强心药,利尿药和止血药,也是潜在的抗肺癌药物。 | |||
T15245 |
Erythromycin estolate
Phtalic anhydride,ilosone |
Antibacterial | Microbiology/Virology |
Erythromycin estolate 是红霉素的衍生物,属于大环内酯类抗生素,常用于研究多种细菌感染。酯酸红霉素对胆汁酸转运有抑制作用,可引起肝损伤,主要是胆汁淤积性肝炎。 | |||
TN4660 |
Niranthin
|
Anti-infection; HBV; PAFR; Topoisomerase | DNA Damage/DNA Repair; GPCR/G Protein; Microbiology/Virology |
Niranthin 是一种木脂素,具有广泛的药理活性。它是L. donovaniIB 拓扑异构酶的非竞争性抑制剂,可用于研究耐药利什曼病的治疗。 | |||
T0690 |
Quinine
奎宁树 |
Potassium Channel; Platelet aggregation; Parasite | Membrane transporter/Ion channel; Microbiology/Virology; Others |
Quinine 是一种从金鸡纳树皮中提取的生物碱,用于预防和治疗疟疾。它也用于特发性肌肉痉挛,可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其IC50值为 169 μM,是一种钾离子通道抑制剂。 | |||
T2754 |
Oxymatrine
Oxysophoridine,氧化苦参碱,Matrine N-oxide |
Influenza Virus; Autophagy; TGF-beta/Smad | Autophagy; Microbiology/Virology; Stem Cells |
Oxymatrine (Oxysophoridine) 是来自槐属物种根部的一种生物碱,具有抗炎,抗纤维化和抗肿瘤的作用。它是一种用于治疗乙型肝炎病毒的中药。它可抑制博卡病毒 MVC 复制,降低病毒基因表达并减少病毒感染诱导的细胞凋亡。它还可以抑制 iNOS 的表达和 TGF-β/Smad 通路。 | |||
T2787 |
Picroside I
6'-Cinnamoylcatalpol,胡黄连苦苷I |
MMP; STAT | JAK/STAT signaling; Proteases/Proteasome; Stem Cells |
Picroside I (6'-Cinnamoylcatalpol) 是胡黄连的一种天然产物,是有肝脏保护作用的代谢成分,可用于哮喘研究,有减轻炎症作用,还下调 pSTAT6 和 GATA3 表达。 | |||
T5S2343 |
Acetylshikonin
乙酰紫草素,Acetyl shikonin |
Others; P450; AChE | Metabolism; Neuroscience; Others |
Acetylshikonin 来源于紫草根,具有抗癌、抗炎作用。它是一种 AChE 抑制剂,具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂,对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。 | |||
T3794 |
Pentagalloylglucose
Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖 |
Influenza Virus | Microbiology/Virology |
1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中,具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。 | |||
TMA0993 |
Ganoderic acid E
灵芝酸F,Ganoderic acid F |
Antiviral | Immunology/Inflammation |
Ganoderic acid F has anti-hepatitis B, anti-inflammatory, and anti-tumor-promoting activities. | |||
TN2185 |
Schisantherin C
|
Others | Others |
Schisantherin A, B, C, and D show good effect in lowering the serum glutamic-pyruvic transaminase level of the patients suffering from chronic virus hepatitis. | |||
T26111 |
Robustaflavone
|
||
Robustaflavone is a naturally occurring biflavanoid isolated from Rhus succedanea and is a hepatitis B virus replication inhibitor. | |||
TN3012 | 4,5-Dihydroblumenol A | HBV | Microbiology/Virology |
4, 5-Dihydroblumenol shows significant inhibition against HepG2 cells transected with cloned hepatitis B virus DNA. | |||
------------------------ 更多 ------------------------ |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-05822 |
Hepatitis B Virus (HBV)(ayw/France/Tiollais/1979) Capsid protein (His)
|
HBV-D | E. coli |
Hepatitis B virus (HBV) capsid assembly is a critical step in the propagation of the virus and is mediated by the core protein. The first cytoplasmic step in the formation of an infectious HBV virion is the formation of a capsid containing pregenomic RNA (pgRNA) and the viral polymerase (Pol). HBV capsid assembly is an attractive target for new antiviral therapies. | |||
TMPY-01621 |
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His)
TIMD-3,hepatitis A virus cellular receptor 2,HAVcr-... |
Human | HEK293 Cells |
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.3 kDa and the accession number is AAL65157.1. | |||
TMPY-05227 |
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated
TIMD3,hepatitis A virus cellular receptor 2,CD366,K... |
Human | HEK293 Cells |
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.3 kDa and the accession number is AAL65157.1. | |||
TMPY-01455 |
TIM-1/KIM-1/HAVCR1 Protein, Rat, Recombinant (His)
hepatitis A virus cellular receptor 1 |
Rat | HEK293 Cells |
TIM-1/KIM-1/HAVCR1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is O54947. | |||
TMPY-01350 |
TIM-1/KIM-1/HAVCR1 Protein, Canine, Recombinant (His)
hepatitis A virus cellular receptor 1 |
Canine | HEK293 Cells |
TIM-1/KIM-1/HAVCR1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.6 kDa and the accession number is A0A8C0N5Y0. | |||
TMPY-01671 |
TIM-1/KIM-1/HAVCR1 Protein, Rhesus, Recombinant (His)
hepatitis A virus cellular receptor 1 |
Rhesus | HEK293 Cells |
TIM-1/KIM-1/HAVCR1 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is BAJ61041.1. | |||
TMPY-01951 |
TIM-1/KIM-1/HAVCR1 Protein, Rhesus, Recombinant
hepatitis A virus cellular receptor 1 |
Rhesus | HEK293 Cells |
TIM-1/KIM-1/HAVCR1 Protein, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32.4 kDa and the accession number is BAJ61041.1. | |||
TMPH-00809 |
Hepatitis C Genome polyprotein (His)
Genome polyprotein |
HCV | E. coli |
Hepatitis C Genome polyprotein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 71.3 kDa and the accession number is S4UAW6. | |||
TMPY-01317 |
TIM-1/KIM-1/HAVCR1 Protein, Rat, Recombinant (His & hFc)
hepatitis A virus cellular receptor 1 |
Rat | HEK293 Cells |
TIM-1/KIM-1/HAVCR1 Protein, Rat, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with hHis and Fc tag. The predicted molecular weight is 52.6 kDa and the accession number is O54947. | |||
TMPY-00553 |
TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (hFc)
hepatitis A virus cellular receptor 2 |
Cynomolgus | HEK293 Cells |
TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is G7P6Q7. | |||
TMPY-04280 |
TIM-1/KIM-1/HAVCR1 Protein, Canine, Recombinant (mFc)
hepatitis A virus cellular receptor 1 |
Canine | HEK293 Cells |
TIM-1/KIM-1/HAVCR1 Protein, Canine, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 41.8 kDa and the accession number is A0A8C0N5Y0. | |||
TMPK-01491 |
HLA-A*02:01&B2M&HBV (FLLTRILTI) Monomer Protein, Human, MHC (His & Avi), Biotinylated
MHC,HBV,Hepatitis B virus |
Human | HEK293 Cells |
Hepatitis B virus (HBV), is the leading cause of liver diseases infecting an estimated 240 million persons worldwide. The HBV prevalence rates are variables between different countries, with an high level of endemicity in the south-eastern part of Europe. Seven main HBV-D subgenotypes have been described until now (D1-D7). | |||
TMPK-01501 |
HLA-A*02:01&B2M&HBV (FLLTRILTI) Tetramer Protein, Human, MHC (His & Avi)
MHC,Hepatitis B virus,HBV |
Human | HEK293 Cells |
Hepatitis B virus (HBV), is the leading cause of liver diseases infecting an estimated 240 million persons worldwide. The HBV prevalence rates are variables between different countries, with an high level of endemicity in the south-eastern part of Europe. Seven main HBV-D subgenotypes have been described until now (D1-D7). | |||
TMPK-01492 |
HLA-A*02:01&B2M&HBV (FLLTRILTI) Monomer Protein, Human, MHC (His & Avi)
Hepatitis B virus,HBV,MHC |
Human | HEK293 Cells |
Hepatitis B virus (HBV), is the leading cause of liver diseases infecting an estimated 240 million persons worldwide. The HBV prevalence rates are variables between different countries, with an high level of endemicity in the south-eastern part of Europe. Seven main HBV-D subgenotypes have been described until now (D1-D7). | |||
TMPY-03677 |
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (hFc)
Tim3,TIM-3,hepatitis A virus cellular receptor 2,Ti... |
Mouse | HEK293 Cells |
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.9 kDa and the accession number is AAL65156.1. | |||
TMPY-03424 |
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (His)
hepatitis A virus cellular receptor 2,TIM-3,Timd3,T... |
Mouse | HEK293 Cells |
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.3 kDa and the accession number is AAL65156.1. | |||
TMPY-01564 |
Hepatitis C virus (HCV-1a) E2 Protein (His)
HCV-1a E2 |
HCV | HEK293 Cells |
Hepatitis C virus (HCV-1a) E2 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32 kDa and the accession number is NP_751921.1. | |||
TMPY-01244 |
TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His & hFc)
TIM-1,KIM-1,Tim1,Timd1,AI503787,hepatitis A virus c... |
Mouse | HEK293 Cells |
TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with hHis and Fc tag. The predicted molecular weight is 49 kDa and the accession number is Q3V033. | |||
TMPH-00812 |
Hepatitis E virus genotype 1 (HEV-1) Protein ORF3 (His & SUMO)
Protein ORF3 |
HEV-1 | E. coli |
Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. Acts also as a viroporin and forms ion conductive pores allowing viral particle release. Impairs the generation of type I interferon by downregulating host TLR3 and TLR7 as well as their downstream signaling pathways. Hepatitis E virus genotype 1 (HEV-1) Protein ORF3 (His & SUMO) is... | |||
TMPH-00814 |
Hepatitis E virus genotype 3 (HEV-3) Capsid protein (His)
Pro-secreted protein ORF2,Protein ORF2 |
HEV-3 | P. pastoris (Yeast) |
Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA. Hepatitis E virus genotype 3 (HEV-3) Capsid protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.3 kDa and the accession number is Q9YLQ9. | |||
TMPH-00810 |
Hepatitis delta virus genotype I (HDV) Large delta antigen Protein (His & Myc)
p27,Large delta antigen |
HDV | P. pastoris (Yeast) |
Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication. Hepatitis delta virus genotype I (HDV) Large delta antigen Protein (His & Myc) is expressed i... | |||
TMPH-00813 |
Hepatitis E virus genotype 1 (HEV-1) Secreted protein ORF2 (His)
Protein ORF2,Pro-secreted protein ORF2 |
HEV-1 | Baculovirus Insect Cells |
Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.; Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation. Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes. Hepatitis E virus gen... | |||
TMPH-00811 |
Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc)
Small delta antigen,p24 |
HDV | P. pastoris (Yeast) |
Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome. Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc) is expressed in yeast with N-6xHi... | |||
TMPY-00296 |
Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His)
HCV-1a E2 |
HCV | HEK293 Cells |
Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.2 kDa and the accession number is BAA03581.1. | |||
TMPY-05463 |
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (mFc)
HAVCR2,TIM3,CD366,TIMD3,hepatitis A virus cellular ... |
Human | HEK293 Cells |
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.2 kDa and the accession number is Q8TDQ0-1. | |||
TMPY-06296 |
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & Avi), Biotinylated
HAVcr-2,KIM-3,TIM3,CD366,HAVCR2,hepatitis A virus c... |
Human | HEK293 Cells |
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 48.41 kDa and the accession number is Q8TDQ0-1. | |||
TMPY-05428 |
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc)
HAVcr-2,KIM-3,Tim-3,TIMD3,HAVCR2,TIMD-3,TIM3,hepatitis |
Human | HEK293 Cells |
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.6 kDa and the accession number is Q8TDQ0-1. | |||
TMPY-05166 |
Hepatitis C virus (HCV) (serotype 1b, isolate HC-J4) Envelope/E2 Protein (His)
HCV-1a E2 |
HCV | HEK293 Cells |
Hepatitis C virus (HCV) (serotype 1b, isolate HC-J4) Envelope/E2 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.4 kDa and the accession number is AAC15723.1. | |||
TMPY-00323 |
Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST)
NS3 |
HCV | E. coli |
HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, t... | |||
TMPY-01768 |
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His)
TIM1,HAVCR-1,KIM1,TIM,TIMD-1,hepatitis A virus cell... |
Human | HEK293 Cells |
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.3 kDa and the accession number is AAC39862.1. | |||
TMPJ-00423 |
TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His)
Hepatitis A virus cellular receptor 1 homolog,HAVcr... |
Mouse | HEK293 Cells |
TIM-1/KIM-1/HAVCR belongs to the immunoglobulin superfamily that cosisits 305 amino acid (aa). It is expressed by stimulated T-cells. TIM-1/KIM-1/HAVCR may play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. And may have a role in kidney injury and repair. Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hypera... | |||
TMPY-01173 |
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 1-135, His)
KIM-1,hepatitis A virus cellular receptor 1,HACVR,C... |
Human | HEK293 Cells |
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 1-135, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.8 kDa and the accession number is AAC39862.1. | |||
TMPY-01161 |
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His & hFc)
KIM1,HACVR,hepatitis A virus cellular receptor 1,TI... |
Human | HEK293 Cells |
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with hHis and Fc tag. The predicted molecular weight is 57 kDa and the accession number is AAC39862.1. | |||
TMPY-04135 |
Hepatitis C virus Envelope Glycoprotein E1/HCV-E1 (subtype 1b, strain HC-J4) Protein (His)
HCV-E1 |
HCV | HEK293 Cells |
Hepatitis C virus Envelope Glycoprotein E1/HCV-E1 (subtype 1b, strain HC-J4) Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.7 kDa and the accession number is AAC15725.1. | |||
TMPJ-00624 |
TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His)
Tim3,HAVcr-2,Timd3,Hepatitis A virus cellular recep... |
Marmoset | HEK293 Cells |
TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-45 KDa and the accession number is F7I881. | |||
TMPJ-00599 |
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His)
TIM3,Hepatitis A virus cellular receptor 2,KIM-3,T-... |
Human | HEK293 Cells |
Hepatitis A virus cellular receptor 2(HAVCR2)is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T ... | |||
TMPJ-00173 |
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His)
T-cell membrane protein 3,T-cell immunoglobulin and mucin do... |
Mouse | HEK293 Cells |
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-50 KDa and the accession number is Q8VIM0. | |||
TMPJ-00174 |
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His)
T-cell immunoglobulin mucin receptor 3,Hepatitis A ... |
Mouse | HEK293 Cells |
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-55 KDa and the accession number is Q8VIM0. | |||
TMPJ-01273 |
ACY3 Protein, Human, Recombinant (His)
Acylase III,Aminoacylase-3,ACY3,Hepatitis C virus c... |
Human | E. coli |
Aspartoacylase 3, also known as ACY3, N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming), Acylase III, Aminoacylase-3, Aspartoacylase-2, Aspartoacylase-2, HCV core-binding protein 1 and ASPA2, is a member of the Aspartoacylase subfamily. ACY3 plays an important role in deacetylating mercapturic acids in kidney proximal tubules and acts on N-acetyl-aromatic amino acids.ACY3 is located in the cytoplasm of S2 and S3 proximal tubules and the apical domain of S1 proximal tubules. ACY3 ... | |||
TMPY-02285 |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS2 Protein
NS2 Protein |
H1N1 | E. coli |
Non-structural protein 2 (NS2) plays a crucial role in the hepatitis C virus (HCV) assembly. NS2 was predicted to be composed of three transmembrane (TM) segments. Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage but also for infectious virus production.NS2 protein is essential for hepatitis C virus (HCV) replication. NS2 protein was expressed and purified. Aptamers against NS2 protein were raised and ant... | |||
TMPH-01104 |
Claudin-9 Protein-VLP, Human, Recombinant (His)
CLDN9,Claudin-9 |
Human | HEK293 Cells |
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. Claudin-9 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 24.2 kDa and the accession number is O95484. | |||
TMPH-01548 |
IFI6 Protein, Human, Recombinant (B2M & His)
Interferon-induced protein 6-16,IFI6,Interferon alpha-induci... |
Human | E. coli |
Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells. | |||
TMPH-00848 |
OASL Protein, Human, Recombinant (His)
59 kDa 2'-5'-oligoadenylate synthase-like protein,Thyroid re... |
Human | E. coli |
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. OASL Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 65.1 kDa and the accession number is Q15646. | |||
TMPY-02193 |
GOLPH2/GOLM1 Protein, Human, Recombinant (His)
HEL46,PSEC0257,GOLPH2,bA379P1.3,C9orf155,GP73,golgi membrane... |
Human | HEK293 Cells |
Golgi membrane protein 1, also known as Golgi membrane protein GP73, Golgi phosphoprotein 2, and GOLM1, is a protein that belongs to the GOLM1 / CASC4 family. GOLM1 is widely expressed. It is highly expressed in the colon, prostate, trachea, and stomach. It is expressed at a lower level in testis, muscle, lymphoid tissues, white blood cells, and spleen. It is predominantly expressed by cells of the epithelial lineage. GOLM1 is expressed at a low level in the normal liver. Expression significantl... | |||
TMPH-01632 |
MRC1 Protein, Human, Recombinant (His)
Human mannose receptor,C-type lectin domain family 13 member... |
Human | E. coli |
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.; (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.; (Microbial infection) Interacts with Hepatitis B virus envelope protein. MRC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 69.9... | |||
TMPH-01902 |
DDX60 Protein, Human, Recombinant (His)
Probable ATP-dependent RNA helicase DDX60,DEAD box protein 6... |
Human | E. coli |
Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). DDX60 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.1 kDa and the accession number is Q8IY2... | |||
TMPY-02909 |
ASGR2 Protein, Human, Recombinant (His)
HBXBP,ASGPR2,HL-2,asialoglycoprotein receptor 2,ASGP-R2,CLEC... |
Human | HEK293 Cells |
ASGR2 is a subunit of the asialoglycoprotein receptor. Asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. ASGR2 is ... | |||
TMPJ-00420 |
CTLA-4 Protein, Mouse, Recombinant (Flag)
Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-ass... |
Mouse | HEK293 Cells |
Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their fu... | |||
TMPJ-00505 |
Serpin A1 Protein, Human, Recombinant (aa 25-418, His)
Alpha-1-Antiproteinase,α-1-Antiproteinase,SERPINA1,Serpin A1... |
Human | HEK293 Cells |
Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants re... | |||
TMPH-02131 |
SKP2 Protein, Human, Recombinant (His & SUMO)
S-phase kinase-associated protein 2,SKP2,F-box protein Skp2,... |
Human | E. coli |
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UB... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12955 |
Sofosbuvir D6
PSI-7977 D6,GS-7977 D6 |
Others | Others |
Sofosbuvir D6 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity. | |||
T11814 |
Lamivudine 13C,15N2
|
Others | Others |
Lamivudine 13C,15N2, an impurity of Lamivudine (BCH-189), functions as an inhibitor of both HIV-1/2 reverse transcriptase and hepatitis B virus reverse transcriptase, classifying it as a nucleoside reverse transcriptase inhibitor (NRTIs). | |||
TMIH-0524 |
Sofosbuvir-13C-d3
|
||
Sofosbuvir-13C-d3 是 Sofosbuvir 的 13C 和氘代化合物。Sofosbuvir 的 CAS 号为 1190307-88-0。Sofosbuvir 是一种丙型肝炎病毒聚合酶 NS5B 的尿苷单磷酸类似物抑制剂,用作治疗慢性丙型肝炎的抗病毒剂。 | |||
TMIH-0297 |
Ledipasvir-d6
|
||
Ledipasvir-d6 是 Ledipasvir 的氘代化合物。Ledipasvir 的 CAS 号为 1256388-51-8。Ledipasvir 是一种丙型肝炎病毒 NS5A 抑制剂。它也是 P-糖蛋白抑制剂和乳腺癌抗性蛋白抑制剂。 | |||
TMIH-0555 |
Telbivudine-d3
|
||
Telbivudine-d3 是 Telbivudine 的氘代化合物。Telbivudine 的 CAS 号为 3424-98-4。Telbivudine 是一种乙型肝炎病毒复制的抗病毒抑制剂,是一种具有口服活性的胸腺嘧啶核苷类似物。 | |||
T38297 |
Ribavirin-13C5
Ribavirin-13C5 |
||
Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro... |