|
TMPY-06987
|
Wnt Surrogate/Wnt3a Protein, Recombinant
Wnt 3a,wnt3a,Wnt-3a
|
Human
|
HEK293 Cells
|
|
Wnt Surrogate/Wnt3a Protein, Recombinant is expressed in HEK293 mammalian cells with hFc tag. |
|
TMPY-01174
|
DKK1 Protein, Rhesus, Recombinant (N256Q, His)
dickkopf WNT signaling pathway inhibitor 1
|
Rhesus
|
HEK293 Cells
|
|
DKK1 Protein, Rhesus, Recombinant (N256Q, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.2 kDa and the accession number is XP_001098844.1. |
|
TMPY-00775
|
DKK1 Protein, Human, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 1,SK,DKK-1
|
Human
|
HEK293 Cells
|
|
DKK1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.22 kDa and the accession number is I1W660. |
|
TMPY-04811
|
DKK1 Protein, Mouse, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 1,mdkk-1
|
Mouse
|
HEK293 Cells
|
|
DKK1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.6 kDa and the accession number is O54908. |
|
TMPY-01121
|
DKK3 Protein, Mouse, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 3,C87148,A...
|
Mouse
|
HEK293 Cells
|
|
DKK3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is Q9QUN9. |
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TMPH-01960
|
Wnt2b Protein, Human, Recombinant (His & SUMO)
Protein Wnt-2b,WNT2B,Protein Wnt-...
|
Human
|
E. coli
|
|
Wnt2b Protein, Human, Recombinant (His & SUMO) is expressed in in vitro E. coli expression system. |
|
TMPH-01962
|
Wnt4 Protein, Human, Recombinant (His & SUMO)
Protein Wnt-4,WNT4
|
Human
|
E. coli
|
|
Wnt4 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. |
|
TMPH-01961
|
Wnt3a Protein, Human, Recombinant (His)
WNT3A,Protein Wnt-3a
|
Human
|
E. coli
|
|
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube. Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro). Wnt3a Protein, Human, Recombinant (His) is expressed in E. coli ... |
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TMPH-02859
|
Wnt3a Protein, Mouse, Recombinant (His)
Wnt3a,Protein Wnt-3a
|
Mouse
|
E. coli
|
|
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube. Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro). Wnt3a Protein, Mouse, Recombinant (His) is expressed in E. coli ... |
|
TMPH-01957
|
Wnt10a Protein, Human, Recombinant (His)
Protein Wnt-10a,WNT10A
|
Human
|
P. pastoris (Yeast)
|
|
Wnt10a Protein, Human, Recombinant (His) is expressed in Yeast. |
|
TMPH-01963
|
Wnt5a Protein, Human, Recombinant (His)
WNT5A,Protein Wnt-5a
|
Human
|
E. coli
|
|
Wnt5a Protein, Human, Recombinant (His) is expressed in E. coli. |
|
TMPH-02861
|
Wnt7b Protein, Mouse, Recombinant (His & Myc & SUMO)
Wnt7b,Protein Wnt-7b
|
Mouse
|
E. coli
|
|
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. |
|
TMPH-03756
|
Wnt7b Protein, Human, Recombinant (His & Myc & SUMO)
Protein Wnt-7b,WNT7B
|
Human
|
E. coli
|
|
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Wint7b Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 56.3 kDa and ... |
|
TMPH-02857
|
Wnt10a Protein, Mouse, Recombinant (His & Myc)
Wnt10a,Protein Wnt-10a
|
Mouse
|
E. coli
|
|
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae. Requir... |
|
TMPH-02860
|
Wnt6 Protein, Mouse, Recombinant (His & SUMO)
Protein Wnt-6,Wnt6
|
Mouse
|
E. coli
|
|
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Wnt6 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.2 kDa and the accession number is P22727. |
|
TMPH-02862
|
Wnt8b Protein, Mouse, Recombinant (His & Myc & SUMO)
Wnt8b,Protein Wnt-8b
|
Mouse
|
E. coli
|
|
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. |
|
TMPH-02858
|
Wnt2 Protein, Mouse, Recombinant (His)
Protein Wnt-2,INT-1-related protein,Wnt2
|
Mouse
|
E. coli
|
|
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons. |
|
TMPH-02865
|
Wnt3 Protein, Mouse, Recombinant (His & SUMO)
Proto-oncogene Int-4,Proto-oncogene Wnt-3,Wnt
|
Mouse
|
E. coli
|
|
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development. |
|
TMPH-02864
|
Wnt1 Protein, Mouse, Recombinant (His & Myc)
Proto-oncogene Wnt-1,Wnt1,Proto-oncogene I...
|
Mouse
|
E. coli
|
|
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis. |
|
TMPH-01958
|
Wnt2 Protein, Human, Recombinant (His)
Int-1-related protein,WNT2,Protein Wnt-2,I...
|
Human
|
Baculovirus Insect Cells
|
|
Wnt2 Protein, Human, Recombinant (His) is expressed in Baculovirus. |
|
TMPH-01959
|
Wnt2 Protein, Human, Recombinant (E. coli, His)
Int-1-related protein,Protein Wnt-2,WNT2,I...
|
Human
|
E. coli
|
|
Wnt2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. |
|
TMPY-05797
|
DKK1 Protein, Rat, Recombinant (His)
dickkopf WNT signaling pathway inhibitor 1
|
Rat
|
HEK293 Cells
|
|
DKK1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.44 kDa and the accession number is A6I0Z0. |
|
TMPY-06377
|
DKK3 Protein, Human, Recombinant
REIC,dickkopf WNT signaling pathway inhibitor 3,RIG
|
Human
|
HEK293 Cells
|
|
DKK3 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 36.29 kDa and the accession number is Q9UBP4. |
|
TMPY-01175
|
DKK1 Protein, Rhesus, Recombinant (N256Q, mFc)
dickkopf WNT signaling pathway inhibitor 1
|
Rhesus
|
HEK293 Cells
|
|
DKK1 Protein, Rhesus, Recombinant (N256Q, mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 53.5 kDa and the accession number is XP_001098844.1. |
|
TMPJ-00517
|
WIF-1 Protein, Human, Recombinant (His)
Wnt Inhibitory Factor 1,WIF-1,WIF1
|
Human
|
HEK293 Cells
|
|
Wnt Inhibitory Factor 1 (WIF1) is a secreted protein, which binds WNT proteins and inhibits their activities. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. is found to be present in fish, amphibia and mammals. WIF1 is a recurrent target in human salivary gland oncogenesis.WIF1 may be involved in mesoderm segmentation. WIF1 is a tumor suppress... |
|
TMPY-02849
|
WIF1 Protein, Mouse, Recombinant (His)
AW107799,WIF-1,WNT inhibitory factor 1
|
Mouse
|
HEK293 Cells
|
|
WIF1, also known as WIF-1 and wnt inhibitory factor 1, is a secreted protein that binds WNT proteins and inhibits their activities. It contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. WNT proteins are extracellular signaling molecules involved in the control of embryonic development. WIF1 may be involved in mesoderm segmentation and can be detected in fish, amphibia and mammals. WIF-1 is a recurrent target in human salivary gland oncogenesis. Downre... |
|
TMPY-05479
|
DKK1 Protein, Human, Recombinant (hFc)
dickkopf WNT signaling pathway inhibitor 1,DKK-1,SK
|
Human
|
HEK293 Cells
|
|
DKK1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 52.5 kDa and the accession number is I1W660. |
|
TMPH-02437
|
5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc)
TPBG,WAIF1,Wnt-activated inhibitory factor 1,Tropho...
|
Cynomolgus
|
HEK293 Cells
|
|
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 39.9 kDa and the accession number is Q4R8Y9. |
|
TMPH-03392
|
5T4/TPBG Protein, Rat, Recombinant (His & SUMO)
Wnt-activated inhibitory factor 1,Trophoblast glyco...
|
Rat
|
E. coli
|
|
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 51.8 kDa and the accession number is Q5PQV5. |
|
TMPH-02436
|
5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc)
TPBG,Trophoblast glycoprotein,Wnt-activated inhibit...
|
Cynomolgus
|
E. coli
|
|
May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. 5T4/TPBG Protein, Cynomolgus, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.9 kDa and the accession number is Q4R8Y9. |
|
TMPH-03367
|
SOSTDC1 Protein, Rat, Recombinant (His & Myc)
Sostdc1,Sclerostin domain-containing protein 1,Wnt-...
|
Rat
|
HEK293 Cells
|
|
Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner. May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction. Enhances Wnt signaling and inhibits TGF-beta signaling. SOSTDC1 Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 24.6 kDa and the accession number is Q642G2. |
|
TMPY-02115
|
R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)
CRISTIN1,THSD2,R-spondin 3,PWTSR
|
Human
|
HEK293 Cells
|
|
R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify s... |
|
TMPY-04153
|
RNF43 Protein, Human, Recombinant (His)
ring finger protein 43,URCC,RNF43,RNF124
|
Human
|
HEK293 Cells
|
|
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and t... |
|
TMPY-03962
|
AFM Protein, Human, Recombinant (His)
afamin,ALBA,ALB2,ALF
|
Human
|
HEK293 Cells
|
|
Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of... |
|
TMPY-00117
|
FGF-16 Protein, Human, Cynomolgus, Recombinant
fibroblast growth factor 16
|
Human,Cynomolgus
|
Baculovirus Insect Cells
|
|
Fibroblast growth factor 16 (FGF16) is preferentially expressed in the heart after birth, suggesting its regulation is associated with tissue-specific chromatin remodeling and DNA-protein interactions. Mutation of the MEF2 site resulted in a blunting of FGF16 promoter activity in transfected neonatal rat cardiac myocytes, that chromatin remodeling and MEF2 binding in the FGF16 promoter contribute to expression in the postnatal heart. FGF16 involvement in the fine tuning of the human skeleton of ... |
|
TMPH-01825
|
NOTUM Protein, Human, Recombinant (His)
NOTUM,hNOTUM,Palmitoleoyl-protein carboxylesterase NOTUM
|
Human
|
E. coli
|
|
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. NOTUM Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.8 kDa and the accession number is Q6P988. |
|
TMPH-01275
|
ZNRF3 Protein, Human, Recombinant (His)
ZNRF3,RING-type E3 ubiquitin transferase ZNRF3,RING finger p...
|
Human
|
HEK293 Cells
|
|
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs ... |
|
TMPH-01274
|
ZNRF3 Protein, Human, Recombinant (His & SUMO)
RING-type E3 ubiquitin transferase ZNRF3,E3 ubiquitin-protei...
|
Human
|
E. coli
|
|
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs ... |
|
TMPJ-00156
|
DKK1 Protein, Human, Recombinant (Avi & His), Biotinylated
Dickkopf-1,Dickkopf-related protein 1,Dkk-1
|
Human
|
HEK293 Cells
|
|
Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, lim... |
|
TMPJ-00354
|
FZD1/Frizzled 1 Protein, Mouse, Recombinant (hFc)
Frizzled-1,mFz1,Fzd1,Fz-1,Frizzled homolog 1
|
Mouse
|
HEK293 Cells
|
|
Frizzled homolog 1 (FZD1), also known as Frizzled-1, a member of the G-protein-coupled receptor superfamily, mediates Wnt signaling by serving as a co-receptor with LRP-5 for Wnt ligands. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. |
|
TMPH-02886
|
SOST Protein, Mouse, Recombinant (hFc)
Sost,Sclerostin
|
Mouse
|
HEK293 Cells
|
|
Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. |
|
TMPK-01080
|
PTK7/CCK4 Protein, Mouse, Recombinant (His)
PTK7,CCK-4
|
Mouse
|
HEK293 Cells
|
|
Protein Tyrosine Kinase 7 (PTK7) is as a critical regulator of canonical and non-canonical Wnt-signaling during embryonic development and cancer cell formation. Disrupting PTK7 activity perturbs vertebrate nervous system development, and also promotes human cancer formation. Observations in different model systems suggest a complex cross-talk between PTK7 protein and Wnt signaling. PTK7/CCK4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted mo... |
|
TMPH-01223
|
DKK2 Protein, Human, Recombinant (His & SUMO)
Dickkopf-related protein 2,DKK2,Dickkopf-2,Dkk-2,hDkk-2
|
Human
|
E. coli
|
|
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. DKK2 Prote... |
|
TMPY-04422
|
Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)
CK1g2,casein kinase 1, γ2,casein kinase 1, gamma 2,Casein Ki...
|
Human
|
Baculovirus Insect Cells
|
|
Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha, beta, gamma, and delta). Dishevelled (Dsh), another positive component of the Wnt pathway, becomes phosphorylated in response to Wnt signals. All the CKI isoforms, with the exce... |
|
TMPY-00920
|
SFRP2 Protein, Mouse, Recombinant (His)
secreted frizzled-related protein 2,AI851596,Sdf5
|
Mouse
|
HEK293 Cells
|
|
The Secreted frizzled-related protein (SFRP) family consists of five secreted glycoproteins in humans (SFRP1~5) that act as extracellular signaling ligands. Each SFRP is approximately 3 amino acids in length and contains a cysteine-rich domain (CRD) that shares 3-5% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs are able to bind Wnt proteins and Fz receptors in the extracellular compartment. The in... |
|
TMPY-00918
|
SFRP1 Protein, Human, Recombinant (His)
SARP2,secreted frizzled-related protein 1,FRP-1,FRP1,FRP,Frz...
|
Human
|
HEK293 Cells
|
|
Secreted frizzled-related protein 1, also known as sFRP1, is a 35 kDa prototypical member of the SFRP family. SFRP family consists of five secreted glycoproteins in humans acting as extracellular signaling ligands. Each is approximately 3 amino acids in length and contains a cysteine-rich domain (CRD) that shares 3-5% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs act as soluble modulators of Wnt s... |
|
TMPK-00744
|
LRP-6 Protein, Human, Recombinant (mFc)
DCAD2,LRP-6,FLJ90421,LRP6,FLJ90062
|
Human
|
HEK293 Cells
|
|
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte activation, detachment, and transition to myofibroblasts in vivo in response to kidney injury, resulting in attenuated fibrogenesis, capillary rarefaction, and inflammation.LRP-6 interacts closely with PDGF receptor β and TGF-β receptor 1 at the cell membrane, suggesting that it ... |
|
TMPH-01611
|
LGR6 Protein, Human, Recombinant (His)
LGR6,Leucine-rich repeat-containing G-protein coupled recept...
|
Human
|
E. coli
|
|
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to t... |
|
TMPY-00950
|
WISP1/CCN4 Protein, Human, Recombinant (His)
WISP1c,WISP1i,CCN4,WNT1 inducible signaling pathway...
|
Human
|
HEK293 Cells
|
|
CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a ... |
|
TMPK-01227
|
DKK3 Protein, Human, Recombinant (His & Avi), Biotinylated
C87148,Dickkopf-3,Dkk3,RIG-like 7-1,AW061014,REIC,RIG,REICdk...
|
Human
|
HEK293 Cells
|
|
Dkk-3, also known as REIC (Reduced Expansion in Immortalized Cells), is one of four numbered members of the Dickkopf family of Wnt antagonists.DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. DKK3 Protein, Human, Recombinant (His & Avi), Biotinylate... |
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