|
TMPJ-00154
|
IL-15RA Protein, Mouse, Recombinant (hFc, Human Cells)
sIL-15 receptor subunit α,Il15ra,Interleukin-15 receptor sub...
|
Mouse
|
HEK293 Cells
|
|
Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il... |
|
TMPJ-01099
|
IL-15RA Protein, Human, Recombinant (hFc, Human Cells)
interleukin-15 receptor subunit α,IL15RA,interleukin-15 rece...
|
Human
|
HEK293 Cells
|
|
Interleukin 15 Receptor alpha (IL-15Rα) is a transmembrane glycoprotein that plays a pleiotropic role in immune development and function, including the positive maintenance of lymphocyte homeostasis. IL-15Rα chain can bind soluble IL-15 and “transpresent” cytokine to the cells, allowing them to respond to IL-15. Soluble IL-15Rα can function as a specific high-affinity IL-15 antagonist. The soluble IL-15/IL-15Rα complexes exhibit a strong agonistic activity which is mediated through membrane-boun... |
|
TMPJ-00261
|
TGF beta 2 Protein, Mouse/Rat, Recombinant
transforming growth factor β-2,BSC-1 cell growth in...
|
Mouse,Rat
|
HEK293 Cells
|
|
Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure. Mice with TGF-β2 gene deletion show defects in development of cardiac, lung, craniofacial, limb, spinal column, eye, inner ear and urogenital systems. All TGF-β isoforms signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the n... |
|
TMPJ-00249
|
TGF beta 1 Protein, Human, Recombinant (Avi), Biotinylated
TGF-Beta-1,TGFB1,Transforming Growth Factor β-1,Lat...
|
Human
|
HEK293 Cells
|
|
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family... |
|
TMPK-00925
|
Noggin/NOG Protein, Mouse, Recombinant
NOG,SYM1,SYNS1,Noggin
|
Mouse
|
HEK293 Cells
|
|
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt. Noggin/NOG... |
|
TMPJ-00651
|
CD155/PVR Protein, Human, Recombinant (aa 21-343, His)
Poliovirus Receptor,PVS,Nectin-Like Protein 5,NECL-5,CD155,P...
|
Human
|
HEK293 Cells
|
|
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension be... |
|
TMPJ-00542
|
TPSB2 Protein, Human, Recombinant (His)
Tryptase-2,Tryptase Beta-2,TPS2,TPSB2,Tryptase II,Tryptase <...
|
Human
|
HEK293 Cells
|
|
Tryptases are Trypsin-like Serine Proteases. β-Tryptases are the main isoenzymes in mast cells. Βtryptases form active tetramers with heparin proteoglycan. In the tetramer, the unique arrangement of the active sites facing a narrow central pore, β-Tryptases are resistant to macromolecule protease inhibitors . When mast cells are activated, β-Tryptases are released and participate in provoking inflammatory conditions . β-Tryptases have been implicated as mediators in the pathogenesis of asthma an... |
|
TMPJ-01243
|
DEFB4 Protein, Human, Recombinant
DEFB4,DEFB104B,hBD-4,DEFB104,BD-4,DEFB-4,Beta-Defensin 104,B...
|
Human
|
E. coli
|
|
Defensins are cationic peptides. It is an important ingredient of the innate immune system. β-defensins are expressed on some leukocytes and epithelial surfaces. Four human β-Defensins have been identified to date: BD-1, BD-2, BD-3 and BD-4. β-defensins contain a six-cysteine motif, they forms three intra-molecular disulfide bonds. β-defensins are also chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursor... |
|
TMPJ-00572
|
Vasorin Protein, Human, Recombinant (His)
Vasorin,VASN,SLITL2,Protein Slit-Like 2
|
Human
|
HEK293 Cells
|
|
Vasorin is a Type I membrane protein, which is predominantly expressed in vascular smooth muscle cells in a developmentally regulated pattern. The expression level of Vasorin can be down regulated during vessel repair after arterial injury. Vasorin binds to transforming growth factor beta (TGF-β) and attenuates TGF-β signaling in vitro. |
|
TMPJ-01055
|
HBA1 Protein, Human, Recombinant (His)
α-globin,Hemoglobin subunit alpha,HBH,HBA-T3,Alpha-globin,He...
|
Human
|
E. coli
|
|
Hemoglobin subunit alpha 1 (HBA1), also known as α2β2, is a hetero-tetramer consisting of two α and two β subunits held together by non-covalent interactions. Each subunit contains a heme group with an iron atom in the Fe2+ state. Cooperativity of Hemoglobin (Hb) in binding with O2 and allosteric regulatory binding properties with CO2, H+, Cl−, and 2,3-DPG (2,3-bisphosphoglycerate) are based on subunit interactions. HBA1 is the most common type of Hb in adult humans, which mediates the transport... |
|
TMPJ-00003
|
DEFB1 Protein, Human, Recombinant
Beta-Defensin 1,BD-1,HBD1,Defensin β1,BD1,Defensin ...
|
Human
|
E. coli
|
|
β-Defensin 1 (DEFB1) is a member of the β-defensin family, which is highly expressed by epithelial cells. β-defensins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal peptide. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-defensin 1 is an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. Defects in β-Defensin-1 contribute to asthma diagnosis,... |
|
TMPY-03058
|
SLITL2/VASN Protein, Human, Recombinant (His)
SLITL2,vasorin
|
Human
|
HEK293 Cells
|
|
Vasorin is a typical type I membrane protein. It contains 1 EGF-like domain, 1 fibronectin type-III domain, 10 LRR (leucine-rich) repeats, 1 LRRCT domain and 1 LRRNT domain. Vasorin is predominantly expressed in vascular smooth muscle cells, and that its expression is developmentally regulated. vasorin It directly binds to transforming growth factor (TGF)-β and attenuates TGF-β signaling in vitro. This suggests that down-regulation of vasorin expression contributes to neointimal formation after ... |
|
TMPJ-00786
|
ITGB1 Protein, Human, Recombinant (aa 21-728, His)
Integrin Beta-1,VLA-4 Subunit β,Fibronectin Recepto...
|
Human
|
HEK293 Cells
|
|
Integrin β-1 (ITGB1) belongs to the integrin β chain family. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. ITGB1 is an integrin unit associated with very late antigen receptors, which contains one VWFA domain. It is known to conjoin with α-3 subunit to create α3β1 complex that reacts to such molecules as netrin-1 and ree... |
|
TMPJ-00771
|
TGF beta 1 Protein, Mouse/Rat, Recombinant
TGFB,TGFbeta,CEDLAP,TGF-beta-1,TGF-beta 1 protein,latency-as...
|
Mouse,Rat
|
HEK293 Cells
|
|
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II)... |
|
TMPJ-00415
|
HGFR/c-Met Protein, Human, Recombinant (aa 25-932, His & Avi), Biotinylated
SF receptor,HGF receptor,Scatter factor receptor,Tyrosine-pr...
|
Human
|
HEK293 Cells
|
|
Hepatocyte growth factor receptor (HGF R) is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domai... |
|
TMPK-00155
|
DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi)
hDkk-1,Dickkopf-1,Dkk1,hDkk1,SK,Dkk-1,Dickkopf-related 1
|
Human
|
HEK293 Cells
|
|
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 38.69 kDa and the accession number is O94907. |
|
TMPK-00223
|
Ephrin B2/EFNB2 Protein, Human, Recombinant (hFc)
Ephrin B2,EFNB2,EPLG5,LERK5,HTKL
|
Human
|
HEK293 Cells
|
|
Ephrin-B2 controls platelet-derived growth factor receptor β (PDGFRβ) distribution in the VSMC plasma membrane, endocytosis, and signaling in a fashion that is highly distinct from its role in the endothelium. Ephrin-B2 is an important regulator of PDGFRβ endocytosis and thereby acts as a molecular switch controlling the downstream signaling activity of this receptor in mural cells. |
|
TMPK-00156
|
DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi)
Dickkopf-1,Dkk1,hDkk-1,hDkk1,Dkk-1,SK,Dickkopf-related 1
|
Human
|
HEK293 Cells
|
|
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 40.25 kDa and the accession number is O94907. |
|
TMPK-00158
|
DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated
hDkk1,Dkk1,Dickkopf-1,Dkk-1,Dickkopf-related 1,SK,hDkk-1
|
Human
|
HEK293 Cells
|
|
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 40.25 kDa and the accession number is O94907. |
|
TMPK-00157
|
DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated
hDkk-1,SK,Dkk1,Dickkopf-related 1,Dickkopf-1,Dkk-1,hDkk1
|
Human
|
HEK293 Cells
|
|
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes. DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 38.69 kDa and the accession number is O94907. |
|
TMPJ-00792
|
DNA PolymeraseBeta Protein, Human, Recombinant (His)
DNA Polymeraseβ,POLB,DNA Polymerase Beta,DNA Polyme...
|
Human
|
E. coli
|
|
Human DNA polymerase β is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. It conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a proce... |
|
TMPK-00997
|
SEZ6 Protein, Human, Recombinant (hFc)
SEZ-6,BSRP-C,SEZ6,BSRPC
|
Human
|
HEK293 Cells
|
|
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is... |
|
TMPK-01065
|
SEZ6 Protein, Mouse, Recombinant (His)
BSRP-C,SEZ-6,BSRPC,SEZ6
|
Mouse
|
HEK293 Cells
|
|
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... |
|
TMPK-00541
|
SEZ6 Protein, Cynomolgus, Recombinant (His)
SEZ-6,BSRPC,BSRP-C,SEZ6
|
Cynomolgus
|
HEK293 Cells
|
|
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weig... |
|
TMPK-00926
|
Noggin/NOG Protein, Mouse, Recombinant (His & Flag)
SYNS1,NOG,SYM1,Noggin
|
Mouse
|
HEK293 Cells
|
|
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt. Noggin/NOG... |
|
TMPJ-01234
|
IL-36 gamma Protein, Mouse, Recombinant
白介素,Interleukin-36 γ,IL-1F9,Interleukin-36 gamma,IL-1 epsilo...
|
Mouse
|
E. coli
|
|
Interleukin-36 gamma (IL-36γ) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in both neuronal and synovial tissue, whereas IL-36β and IL-36γ are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36β and IL-36γ stimulate proliferation, maturation and/or cytokine expression by innate immune cells (such as keratinocyte... |
|
TMPJ-00160
|
EMMPRIN/CD147 Protein, Human, Recombinant (His)
5F7,TCSF,OK Blood Group Antigen,Tumor Cell-Derived Collagena...
|
Human
|
HEK293 Cells
|
|
Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) belongs to the immunoglobulin superfamily, which has the homology to both the immunoglobulin V domain and MHC class II antigen β-chain. EMMPRIN is a transmembrane glycoprotein with different forms, resulting from different modes of glycosylation and N-terminal sequence variants. EMMPRIN can be expressed in breast cancer, oral squamous cell carcinoma, glioma, lymphoma, lung, bladder, and melanoma carcinomas cells. EMMPRIN promotes invasion,... |
|
TMPK-00998
|
SEZ6 Protein, Human, Recombinant (His)
BSRPC,BSRP-C,SEZ-6,SEZ6
|
Human
|
HEK293 Cells
|
|
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is... |
|
TMPJ-01061
|
Nucleobindin-2 Protein, Human, Recombinant
NUCB2,NEFA,Gastric cancer antigen Zg4,Nesfatin-1,Prepronesfa...
|
Human
|
E. coli
|
|
Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage. Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic islets β-cells, gastric endocrine cells and adipocytes. Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner. Nesfatin-1 may ... |
|
TMPK-00996
|
SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated
BSRPC,BSRP-C,SEZ6,SEZ-6
|
Human
|
HEK293 Cells
|
|
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. SEZ6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predi... |
|
TMPK-00328
|
TGFBR2 Protein, Human, Recombinant (mFc & Avi)
TAAD2,LDS2B,LDS2,MFS2,TGFBR2,AAT3,LDS1B,TGFβR2,Tbet...
|
Human
|
HEK293 Cells
|
|
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division. TGFBR2 Protein, Human, Recombinant (mFc & Avi) is expressed in HEK293 mammalian cells with C-mFc-Avi tag. The pred... |
|
TMPK-01304
|
Kremen-2 Protein, Cynomolgus, Recombinant (His)
KREMEN2,KRM2,Dickkopf receptor 2,Kremen-2
|
Cynomolgus
|
HEK293 Cells
|
|
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy. Kremen-2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian c... |
|
TMPJ-00457
|
OGG1 Protein, Human, Recombinant
OGH1,N-Glycosylase/DNA Lyase,DNA-(Apurinic or Apyrimidinic S...
|
Human
|
E. coli
|
|
Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma. |
|
TMPK-01093
|
Kremen-2 Protein, Mouse, Recombinant (His)
KRM2,KREMEN2,Dickkopf receptor 2,Kremen-2
|
Mouse
|
HEK293 Cells
|
|
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy. Kremen-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells ... |
|
TMPK-01106
|
Kremen-2 Protein, Human, Recombinant (His)
KRM2,KREMEN2,Kremen-2,Dickkopf receptor 2
|
Human
|
HEK293 Cells
|
|
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy. Kremen-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells ... |
|
TMPK-00329
|
TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated
LDS2B,TbetaR-II,TGFβR2,LDS2,RIIC,TGF-β RII...
|
Human
|
HEK293 Cells
|
|
The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division. TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-mFc-Avi... |
|
TMPJ-00028
|
CCL2 Protein, Mouse, Recombinant
Ccl2,Je,Mcp1,C-C motif chemokine 2,Platelet-derived growth f...
|
Mouse
|
E. coli
|
|
C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major... |
|
TMPK-00457
|
HGFR/c-Met Protein, Human, Recombinant (His & Avi)
cMET,Met (c-Met),MET,HGF/SF receptor,SF receptor,RCCP2,AUTS9...
|
Human
|
HEK293 Cells
|
|
c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ... |
|
TMPJ-00292
|
CD36 Protein, Human, Recombinant (hFc)
FATCHDS7,Glycoprotein IIIb,SCARB3,CD36,Fatty acid translocas...
|
Human
|
HEK293 Cells
|
|
Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal muscle, epithelial cells of the retina, breast, and intestine, smooth muscle cells, erythroid precursors, platelets, megakaryocytes, dendritic cells, monocytes/macrophages, and microglia. As a member of the scavenger receptor family, CD36 is a multiligand pattern recognition rece... |
|
TMPJ-00680
|
ANGPTL7 Protein, Human, Recombinant (His)
CDT6,Cornea-derived transcript 6 protein,Angiopoietin-like p...
|
Human
|
HEK293 Cells
|
|
Angiopoietin-like 7 (ANGPTL7) is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 shares 89% aa sequence identity with mouse and rat ANGPTL7. It is secreted as a 45-50kDa monomer that forms disulfide-linked homotrimers and tetramers via the coiled coil domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated ... |
|
TMPJ-00993
|
CCL5 Protein, Rat, Recombinant (E. coli, His)
Small-inducible cytokine A5,SIS-δ,C-C motif chemokine 5,T-ce...
|
Rat
|
E. coli
|
|
C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leu... |
|
TMPK-00499
|
HGFR/c-Met Protein, Cynomolgus, Recombinant (His)
MET,oncogene MET,cMET,SF receptor,HGF/SF receptor,AUTS9,Met ...
|
Cynomolgus
|
HEK293 Cells
|
|
c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. HGFR/c-Met ... |
|
TMPY-03627
|
CREB3L1 Protein, Human, Recombinant (aa 396-519, His)
OASIS,PSEC0238,cAMP responsive element binding protein 3-lik...
|
Human
|
HEK293 Cells
|
|
CREB3L1, also known as OASIS, is a cellular transcription factor synthesized as a membrane-bound precursor. It is a putative endoplasmic reticulum (ER) stress sensor in astrocytes with a mechanism of activation. OASIS mRNA expression was detected in pancreatic β-cell lines and rodent islets, and the expression level was up-regulated by ER stress-inducing compounds. CREB3L1 may have a role in pancreas development. CREB3L1 may also play an important role in limiting virus spread by inhibiting prol... |
|
TMPJ-00933
|
PRDX5 Protein, Human, Recombinant (His)
Antioxidant enzyme B166,Alu corepressor 1,Peroxiredoxin-5,PL...
|
Human
|
HEK293 Cells
|
|
Peroxisomes are essential organelles that participate in multiple important metabolic processes, including the β-oxidation of fatty acids, plasmalogen synthesis, and the metabolism of reactive oxygen species (ROS). Peroxiredoxins is overexpressed in breast cancer tissues to a great extent suggesting that they has a proliferative effect and may be related to cancer development or progression. Peroxiredoxin 5 (PRDX5) is a thioredoxin peroxidase that belongs to the atypical 2-Cys class of the TSA/a... |
|
TMPJ-00100
|
Artemin Protein, Human, Recombinant
ARTN,Artemin,EVN,Enovin,Neublastin
|
Human
|
E. coli
|
|
Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I... |
|
TMPJ-00238
|
Lefty-A Protein, Human, Recombinant (His)
Endometrial bleeding-associated factor,TGFB4,TGF-β-...
|
Human
|
HEK293 Cells
|
|
Left-right determination factor 2(LEFTY2) is a secreted protein which belongs to the TGF-beta family. Lefty was first identified in a screen for undifferentiated cell-specific cDNAs from the P19 mouse embryonal carcinoma cells. Its mRNA expression on the left side of the developing embryo earned the name “Lefty”. The human orthologue was initially identified as Ebaf, Endometrial bleeding associated factor. Lefty contains the six cysteine residues that are conserved among TGF-β related proteins a... |
|
TMPJ-00304
|
ALK-1 Protein, Mouse, Recombinant (hFc)
TSR-I,Serine/threonine-protein kinase receptor R3,ALK-1,SKR3...
|
Mouse
|
HEK293 Cells
|
|
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1... |
|
TMPY-03861
|
Amelotin Protein, Human, Recombinant (mFc)
amelotin,UNQ689
|
Human
|
HEK293 Cells
|
|
Amelotin (AMTN) is a tooth enamel protein which is expressed in maturation-stage ameloblasts and also in the internal basal lamina of junctional epithelium, a unique epithelial structure attached to the tooth surface which protects against the constant microbiological challenge to the periodontium. TNF-α stimulates AMTN gene transcription in human gingival epithelial cells via C/EBP1, C/EBP2, and YY1 elements in the human AMTN gene promoter.AMTN mRNA levels increased at 6 h and reached maximum a... |
|
TMPY-03341
|
ASF1B Protein, Human, Recombinant (His)
anti-silencing function 1B histone chaperone,CIA-II
|
Human
|
Baculovirus Insect Cells
|
|
The histone chaperone anti-silencing factor 1a (ASF1a) interacts with MDC1 and is recruited to sites of DSBs to facilitate the interaction of phospho-ATM with MDC1 and phosphorylation of MDC1, which are required for the recruitment of RNF8/RNF168 histone ubiquitin ligases. Thus, ASF1a deficiency reduces histone ubiquitination at DSBs, decreasing the recruitment of 53BP1, and decreases NHEJ, rendering cells more sensitive to DSBs. This role of ASF1a in DSB repair cannot be provided by the closely... |
|
TMPY-01052
|
R-Cadherin/CDH4 Protein, Human, Recombinant (His)
R-CAD,cadherin 4, type 1, R-cadherin (retinal),RCAD,CAD4
|
Human
|
HEK293 Cells
|
|
The cadherin superfamily is a large family that engage in both homo- and heterotypic, calcium-dependent, cell-cell adhesion events, and can be divided into at least four subfamilies based on the extracellular (EC) regions and cytoplasmic domains, that is: classical cadherins, desmosomal cadherins, protocadherins, and cadherin-like molecules. Human cadherin 4, type 1, R-cadherin (retinal), also known as CDH4, CAD4 and RCAD, is a classical cadherin from the cadherin superfamily. It is a calcium-de... |
沪公网安备 31010602006700号