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Indacaterol maleate

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产品编号 T1239Cas号 753498-25-8
别名 马来酸茚达特罗, QAB149

Indacaterol maleate (QAB149) 是一种超长效的 β-肾上腺素受体激动剂。

Indacaterol maleate

Indacaterol maleate

Rating icon 很棒
纯度: 99.67%
产品编号 T1239 别名 马来酸茚达特罗, QAB149Cas号 753498-25-8

Indacaterol maleate (QAB149) 是一种超长效的 β-肾上腺素受体激动剂。

规格价格库存数量
5 mg¥ 248现货
10 mg¥ 348现货
25 mg¥ 563现货
50 mg¥ 878现货
100 mg¥ 1,470现货
200 mg¥ 2,250现货
500 mg¥ 3,830现货
1 mL x 10 mM (in DMSO)¥ 312现货
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产品介绍

生物活性
产品描述
Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.
靶点活性
β2-adrenoceptor:5.48(pKi), β1-adrenoceptor:7.36(pKi)
体外活性
Indacaterol inhibits cAMP production in Chinese hamster ovary cells stably transfected with human β2 adrenoceptors with pEC50 of 8.06. Indacaterol inhibits electrically induced contraction on the electrically stimulated guinea pig trachea in a concentration-dependent manner with pEC50 of 8.23. Indacaterol induces a concentration-dependent inotropic effect with maximal efficacy of 75% in the isolated guinea pig left atrium. [1] Indacaterol reverses the carbachol-induced contraction in a concentration-dependent manner with IC50 of 37 nM in human small airways. Indacaterol concentration dependently reverses the serotonin-induced contraction with IC50 of 10.5 nM in rat small airways. Indacaterol has the highest intrinsic efficacy of 53% in rat small airways and 73% in human small airways. [2] Indacaterol (10 μM) induces close to full inhibition of the EFS-induced contraction of isolated human bronchi and the effect lasts 12 hours. [3] Indacaterol inhibits the IgE-dependent release of histamine from mast cells with the intrinsic activity (Emax of a long-acting Indacaterol/Emax of Isoprenaline) of 1.03. [4] Indacaterol inihbits cAMP release from human airway smooth muscle with pEC50 of 8.53 and Emax of 48%. Indacaterol appears to have a reduced efficacy compared with the CHO-K1 data in the primary ASM cells. [5]
体内活性
Indacaterol (6.7 μg/kg) inhibits 5-HT-induced bronchoconstriction with a maximal effect of 85% in the conscious guinea pig. Indacaterol (12.5 μg/kg) dose-dependently inhibits methacholine-induced bronchoconstriction with a maximal effect of 85% in the anesthetized rhesus monkey. [1]
别名马来酸茚达特罗, QAB149
化学信息
分子量508.56
分子式C28H32N2O7
CAS No.753498-25-8
SmilesOC(=O)\C=C/C(O)=O.CCc1cc2CC(Cc2cc1CC)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12
密度no data available
储存&溶解度
存储Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度信息
DMSO: 94 mg/mL (184.8 mM)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
溶液配制表
1mg5mg10mg50mg
1 mM1.9663 mL9.8317 mL19.6634 mL98.3168 mL
5 mM0.3933 mL1.9663 mL3.9327 mL19.6634 mL
10 mM0.1966 mL0.9832 mL1.9663 mL9.8317 mL
20 mM0.0983 mL0.4916 mL0.9832 mL4.9158 mL
50 mM0.0393 mL0.1966 mL0.3933 mL1.9663 mL
100 mM0.0197 mL0.0983 mL0.1966 mL0.9832 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法:
TargetMol | Animal experiments比如您的给药剂量是 10 mg/kg ,每只动物体重 20 g ,给药体积 100 μLTargetMol | Animal experiments 一共给药动物 10 只 ,您使用的配方为 5% TargetMol | reagent DMSO+ 30%PEG300+ 5%Tween 80 + 60% ddH2O. 那么您的工作液浓度为 2 mg/mL
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent ( 母液浓度为 40 mg/mL ), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:50μLDMSOTargetMol | reagent 母液,添加 300 μLPEG300TargetMol | reagent 混匀澄清,再加 50μLTween 80, 混匀澄清,再加 600μLddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。

1 请输入动物实验的基本信息
mg/kg
g
μL
2 请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
%Tween 80
%ddH2O

剂量转换

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