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TMPY-03425
|
Tau Protein, Human, Recombinant (His)
PPND,FTDP-17,MTBT1,DDPAC,MAPTL,MTBT2,microtubule-as...
|
Human
|
E. coli
|
|
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP... |
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TMPH-01685
|
MAST4 Protein, Human, Recombinant (His & Myc)
Microtubule-associated serine/threonine-protein kin...
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Human
|
E. coli
|
|
MAST4 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. |
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TMPY-03340
|
MAP1LC3A Protein, Human, Recombinant (His)
LC3,ATG8E,microtubule-associated protein 1 light ch...
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Human
|
E. coli
|
|
LC3A, also known as MAP1LC3A, is one of the light chain subunits that function together with both MAP1A and/or MAP1B. MAP1A and MAP1B are microtubule-associated proteins that mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. As a light chain subunit, MAP1LC3A has an important part in neuronal development and in maintaining the balance between neuronal plasticity and r... |
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TMPY-03749
|
LC3B Protein, Human, Recombinant (His)
microtubule-associated protein 1 light chain 3 beta...
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Human
|
E. coli
|
|
MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. LC3B is a member of the MAP1 LC3 family. It is most abundantly expressed in the heart, brain, skeletal muscle, and testis. LC3B is a subunit of the neuronal microtubule and functions in the formation of autophagosomal... |
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TMPH-02785
|
Tau Protein, Mouse, Recombinant (His)
Microtubule-associated protein tau,Mapt,Paired heli...
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Mouse
|
HEK293 Cells
|
|
Tau Protein, Mouse, Recombinant (His) is expressed in HEK293. |
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TMPH-01683
|
Tau-F Protein, Human, Recombinant (HEK293, His)
Microtubule-associated protein tau,Paired helical f...
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Human
|
HEK293 Cells
|
|
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the ... |
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TMPH-03335
|
Tau Protein, Rat, Recombinant (E. coli, His)
Mapt,Neurofibrillary tangle protein,Microtubule-ass...
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Rat
|
E. coli
|
|
Tau Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 82.4 kDa and the accession number is P19332. |
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TMPH-02443
|
Tau Protein, Rhesus macaque, Recombinant (His & SUMO)
Neurofibrillary tangle protein,MAPT,Microtubule-ass...
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Rhesus
|
E. coli
|
|
Tau Protein, Rhesus macaque, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 63.8 kDa and the accession number is P57786. |
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TMPH-03336
|
Tau Protein, Rat, Recombinant (His)
Neurofibrillary tangle protein,Mapt,Paired helical filament-...
|
Rat
|
HEK293 Cells
|
|
Tau Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 81.2 kDa and the accession number is P19332. |
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TMPH-02444
|
Tau Protein, Rhesus macaque, Recombinant (His)
Microtubule-associated protein tau,MAPT,Paired heli...
|
Rhesus
|
HEK293 Cells
|
|
Tau Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 50.6 kDa and the accession number is P57786. |
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TMPJ-00828
|
Tau-F Protein, Human, Recombinant
Neurofibrillary tangle protein,Paired helical filament-tau,M...
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Human
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E. coli
|
|
Tau proteins are proteins which contain four Tau/MAP repeats. They promote microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. The tau proteins are the product of alternative splicing from a single gene that in humans is designated MAPT. When tau proteins are def... |
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TMPH-02113
|
SSNA1 Protein, Human, Recombinant (His)
Sjoegren syndrome nuclear autoantigen 1,Microtubule...
|
Human
|
E. coli
|
|
N/A. SSNA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.0 kDa and the accession number is O43805. |
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TMPY-03865
|
EB3 Protein, Human, Recombinant (His)
microtubule-associated protein, RP/EB family, membe...
|
Human
|
E. coli
|
|
MAPRE3 (Microtubule Associated Protein RP/EB Family Member 3, also known as EB3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. MAPRE3 is a member of the RP/EB family. It localizes to the cytoplasmic microtubule network and binds APCL. MAPRE3 regulates the dynamics of the microtubule cytoskeleton and promotes microtubule growth. It may be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. MAPRE3 may also play a role i... |
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TMPJ-00827
|
Tau-D Protein, Human, Recombinant (His)
PHF-Tau,MAPTL,MAPT,Paired Helical Filament-Tau,Microtubu...
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Human
|
E. coli
|
|
Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective,... |
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TMPJ-01321
|
MAP1LC3B Protein, Human, Recombinant
Autophagy-related ubiquitin-like modifier LC3 B,MAP1A/MAP1B ...
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Human
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E. coli
|
|
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in the MAP1LC3 subfamily (others include MAP1LC3A, MAP1LC3C, and MAP1LC3B2). It is moat abundantly expressed in heart, brain, skeletal muscle and testis. LMAP1LC3B is a subunit of neuronal microtubule and functions in formation of autophagosomal vacuoles (autophagosomes). It associat... |
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TMPH-01684
|
MAP1LC3C Protein, Human, Recombinant (His)
MAP1A/MAP1B light chain 3 C,Microtubule-associated ...
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Human
|
E. coli
|
|
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated and aggregated proteins. MAP1LC3C Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.7 kDa and the accession number is Q9BXW... |
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TMPH-01692
|
MAPK3 Protein, Human, Recombinant (His)
MAP kinase isoform p44,p44-ERK1,MAPK3,Extracellular signal-r...
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Human
|
E. coli
|
|
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c... |
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TMPY-04329
|
Vimentin Protein, Human, Recombinant (His)
CTRCT30,HEL113,vimentin
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Human
|
Baculovirus Insect Cells
|
|
Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers compose the basic subunit of vimentin assembly. Vimentin is crucial for supporting and anchoring the position of the organelles in the cytosol. Vimentin provided cells with a resilience absent from the microtubule or actin filament networks, when under mechanical stress in vivo. ... |
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TMPJ-01076
|
FKBP4 Protein, Human, Recombinant (His)
FKBP4,HSP-binding immunophilin,immunophilin FKBP52,FK506-bin...
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Human
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E. coli
|
|
FKBP4 act as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments, it also may have a protective role against oxidative stress in mitochondria. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. |
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TMPH-01254
|
DNM1 Protein, Human, Recombinant (His)
DNM,Dynamin,Dynamin-1,DNM1,Dynamin I
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Human
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E. coli
|
|
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis. DNM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.2 kDa and the accession number is Q05193. |
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TMPY-03047
|
Stathmin 1 Protein, Human, Recombinant (His)
SMN,OP18,stathmin 1,LAP18,C1orf215,PP17,Lag,PP19,PR22
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Human
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E. coli
|
|
Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and could be a novel therapeutic target in metastatic GC. STMN1 expression might serve as a biomarker for determining patient atypical meningioma prognosis. Stathmin1 (STMN1) is a cytosolic protein involved in microtubule dynamics through inhibition of tubulin polymerization and prom... |
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TMPH-02944
|
TCTP/TPT1 Protein, Mouse, Recombinant (His)
21 kDa polypeptide,p21,Tpt1,Translationally-controlled tumor...
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Mouse
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E. coli
|
|
Involved in calcium binding and microtubule stabilization. TCTP/TPT1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.5 kDa and the accession number is P63028. |
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TMPH-02138
|
Stathmin-4 Protein, Human, Recombinant (GST)
STMN4,Stathmin-4,Stathmin-like protein B3
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Human
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E. coli
|
|
Exhibits microtubule-destabilizing activity. Stathmin-4 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 52.4 kDa and the accession number is Q9H169. |
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TMPH-01592
|
KIF18B Protein, Human, Recombinant (His & Myc)
Kinesin-like protein KIF18B,KIF18B
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Human
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E. coli
|
|
In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. |
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TMPH-01256
|
Dystonin Protein, Human, Recombinant (His & SUMO)
DT,DST,BPAG1,BP240,BP230,KIAA0728,Dystonin,DMH
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Human
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E. coli
|
|
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transpo... |
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TMPH-01257
|
Dystonin Protein, Human, Recombinant (His)
DT,BP230,Dystonin,BP240,DST,DMH,BPAG1,KIAA0728
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Human
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P. pastoris (Yeast)
|
|
Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transpo... |
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TMPH-02313
|
RPGR Protein, Human, Recombinant (hFc)
RPGR,X-linked retinitis pigmentosa GTPase regulator
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Human
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HEK293 Cells
|
|
Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes. May be involved in microtubule organization and regulation of transport in primary cilia. |
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TMPH-03375
|
Stathmin-2 Protein, Rat, Recombinant (His)
Superior cervical ganglion-10 protein,Stmn2,Stathmin-2
|
Rat
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E. coli
|
|
Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. Stathmin-2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26.7 kDa and the accession number is P21818. |
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TMPH-02304
|
Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO)
Vasohibin-2,VASH2,Vasohibin-like protein,Tubulinyl-Tyr carbo...
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Human
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E. coli
|
|
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation. Vasohibin-2/VASH2 Protein, Human,... |
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TMPH-02622
|
DOCK8 Protein, Mouse, Recombinant (E. coli, His)
DOCK8,Dedicator of cytokinesis protein 8
|
Mouse
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E. coli
|
|
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing cent... |
|
TMPY-04025
|
CEP57 Protein, Human, Recombinant (GST)
MVA2,PIG8,TSP57,centrosomal protein 57kDa
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Human
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E. coli
|
|
CEP57 is a centrosomal protein and is involved in nucleating and stabilizing microtubules. CEP57 was initially identified as a regulator of centriole overduplication in an RNA interference screen. There is a link between altered microenvironmental signaling cues such as FGF-2 overexpression and mitotic instability and provide a rationale for the therapeutic targeting of the FGF-2/FGFR1/CEP57 axis in prostate cancer. CEP57 is involved in intracellular transport processes, and its overexpression c... |
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TMPH-01207
|
DOCK8 Protein, Human, Recombinant (His)
DOCK8,Dedicator of cytokinesis protein 8
|
Human
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P. pastoris (Yeast)
|
|
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing c... |
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TMPH-02623
|
DOCK8 Protein, Mouse, Recombinant (His)
Dedicator of cytokinesis protein 8,DOCK8
|
Mouse
|
P. pastoris (Yeast)
|
|
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing cent... |
|
TMPH-00895
|
Human adenovirus B serotype 3 Hexon protein (His & Myc)
Hexon protein,Protein II,L3
|
HAdV-3
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E. coli
|
|
Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus. Hum... |
|
TMPY-03596
|
JTB Protein, Human, Recombinant (mFc)
PAR,hJT,jumping translocation breakpoint,JTB,HSPC222,HJTB
|
Human
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HEK293 Cells
|
|
Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB is expressed in all normal human tissues studied but overexpressed or underexpressed in many of their malignant counterparts. It is required for normal cytokinesis during mitosis. JTB plays a role in the regulation of cell proliferation. It may be a component of the chromosomal... |
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TMPY-02980
|
BLOC1S2 Protein, Human, Recombinant (GST)
CEAP,CEAP11,BLOS2,biogenesis of lysosomal organelles complex...
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Human
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E. coli
|
|
BLOC1S2, also known as BLOS2, belongs to the BLOC1S2 family. It is a component of BLOC-1 complex. The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. BLOC1S2 interacts directly with BLOC1S1, BLOC1S3, MUTED, CNO/cappuccino and SNAPIN. It may play a role in cell proliferation. It also plays a role in intracell... |
|
TMPY-03509
|
TCTP/TPT1 Protein, Human, Recombinant (His)
tumor protein, translationally-controlled 1,HRF,TCTP,p23,p02
|
Human
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E. coli
|
|
Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TPT1) (or P23) is a protein that has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first... |
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TMPH-02846
|
BICD2 Protein, Mouse, Recombinant (GST)
Bicd2,Kiaa0699,Bic-D 2,Protein bicaudal D homolog 2
|
Mouse
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E. coli
|
|
Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (... |
|
TMPY-02718
|
Doublecortin/DCX Protein, Human, Recombinant (aa 45-150, GST)
XLIS,doublecortin,LISX,DBCN,DC,SCLH
|
Human
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E. coli
|
|
DCX (doublecortin, N-GST chimera)contains 2 doublecortin domains and belongs to the doublecortin family. It is highly expressed in neuronal cells of fetal brain, but not expressed in other fetal tissues. In the adult, it is highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas. DCX is a microtubule-associated protein required for initial steps of neuronal dispersion an... |
|
TMPY-04558
|
NEK7 Protein, Human, Recombinant (His & GST)
NIMA-related kinase 7
|
Human
|
Baculovirus Insect Cells
|
|
NIMA (never in mitosis gene a)-related kinase 7, NEK7 belongs to the NIMA subfamily, NEK Ser/Thr protein kinase family, protein kinase superfamily. NEKs (NIMA-related kinases) are mammalian serine/threonine (Ser/Thr) protein kinases structurally related to Aspergillus NIMA (Never in Mitosis, gene A), which plays essential roles in mitotic signaling. NEKs share an amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the control of several aspects of mitosis, and dive... |
|
TMPH-01621
|
BRCC3 Protein, Human, Recombinant (His & SUMO)
BRCC36,CXorf53,C6.1A,BRCC3,BRCA1/BRCA2-containing complex su...
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Human
|
E. coli
|
|
Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, anta... |
|
TMPY-04455
|
PKC iota Protein, Human, Recombinant (GST)
PKCI,nPKC-iota,protein kinase C, ι,DXS1179E,nPKC-ι,protein k...
|
Human
|
Baculovirus Insect Cells
|
|
Protein kinase C iota type, also known as Atypical protein kinase C-lambda/iota, aPKC-lambda/iota and PRKCI, is a cytoplasm, membrane and nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and PKC subfamily. PRKCI contains one AGC-kinase C-terminal domain, one OPR domain, one phorbol-ester/DAG-type zinc finger and one protein kinase domain. PRKCI is predominantly expressed in lung and brain, but also expressed at lower levels in many tissues includ... |
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TMPH-02275
|
Lck Protein, Human, Recombinant (His)
Proto-oncogene Lck,T cell-specific protein-tyrosine kinase,T...
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Human
|
E. coli
|
|
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules... |
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