D8-MMAF

Name: D8-MMAF
Brand: TargetMol
SKU: T10949
Rating: 4.5 (1 reviews)

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产品编号 T10949

别名 Monomethylauristatin F D8

D8-MMAF is a microtubule destroyer, deuterated form of MMAF.

还可以

产品编号 T10949 别名 Monomethylauristatin F D8

D8-MMAF is a microtubule destroyer, deuterated form of MMAF.

规格	价格	库存	数量
100 mg	询价	期货
500 mg	询价	期货

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生物活性

产品描述	D8-MMAF is a microtubule destroyer, deuterated form of MMAF.
体外活性	MMAF showed cytotoxicity in vitro against a group of cell lines. Karpas 299, H3396, 786-O and Caki-1 have IC50 values of 119, 105, 257 and 200 nM, respectively. Targeted MMAF is more effective than free drug, and the cAC10 conjugate of MMAF shows significant activity. On a molar basis, the average potency of cAC10-L1-MMAF4 is more than 2200 times higher than free MMAF, and it is active in all tested CD30 positive cell lines.
体内活性	The maximum tolerated dose of MMAF (> 16 mg / kg) mice is much higher than that of MMAE (1 mg / kg). The MTD of cAC10-L1-MMAF4 is 50 mg / kg in mice and 15 mg / kg in rats. The corresponding cAC10-L4-MMAF4 ADC is much less toxic, with MTD greater than 150 mg / kg and 90 mg / kg in mice and rats, respectively.
别名	Monomethylauristatin F D8