Herpotrichone B exhibits potent anti-neuroinflammatory activity in BV-2 microglial cells induced by lipopolysaccharide (LPS), with a half-maximal inhibitory concentration (IC50) of 0.11μM.
Quinolactactin A is a quinolone fungal metabolite originally isolated from Penicillium. It inhibits TNF production induced by LPS in murine peritoneal macrophages (IC50 = 12.2 μg/ml). It is not active against a variety of bacteria, fungi, and yeasts. Quinolactacin A is a mixture of quinolactacin A1 and A2.