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Beclometasone dipropionate (Vancenase) 是具有口服活性的糖皮质激素,具有抗炎和免疫抑制作用。它是Betamethasone 的前体药物,Betamethasone 是 LPS 诱导的炎症及 MMP 释放的抑制剂。
Beclometasone dipropionate (Vancenase) 是具有口服活性的糖皮质激素,具有抗炎和免疫抑制作用。它是Betamethasone 的前体药物,Betamethasone 是 LPS 诱导的炎症及 MMP 释放的抑制剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 mg | ¥ 178 | 现货 | |
100 mg | ¥ 247 | 现货 | |
500 mg | ¥ 787 | 现货 | |
1 g | ¥ 1,230 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 233 | 现货 |
产品描述 | Beclometasone dipropionate (Vancenase) is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. |
体外活性 | Beclometasone dipropionate (BDP)是用于治疗哮喘和过敏性鼻炎(AR)的抗炎皮质类固醇。BDP曾经开发为治疗AR的水性鼻用制剂。此外,BDP也曾以氯氟烃(CFC)计量剂量吸入器鼻喷雾的形式推出干鼻气雾制剂,但含CFC的制剂已经从市场撤回,目前已不再提供。BDP氢氟烃(HFA)吸入气雾剂目前可供患者使用,适用于5岁及以上患者哮喘的维持治疗和预防治疗。新近研发的BDP HFA鼻用气雾剂,是一种治疗AR的鼻内气雾制剂。 |
别名 | 二丙酸倍氯米松, 丙酸倍氯米松, Vancenase, Beconase, Beclovent, Beclomethasone dipropionate |
分子量 | 521.04 |
分子式 | C28H37ClO7 |
CAS No. | 5534-09-8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (105.56 mM) Ethanol: 18 mg/mL (34.55 mM) | ||||||||||||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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