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B I09是一种 IRE-1 RNase 抑制剂,IC50为1230 nM,对人 WaC3细胞中 XBP1 mRNA 的剪接和 LPS 刺激的 B 细胞中 xbp -1的表达有抑制作用。B I09可用于 CLL 细胞模拟XBP-1缺陷的研究。
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B I09是一种 IRE-1 RNase 抑制剂,IC50为1230 nM,对人 WaC3细胞中 XBP1 mRNA 的剪接和 LPS 刺激的 B 细胞中 xbp -1的表达有抑制作用。B I09可用于 CLL 细胞模拟XBP-1缺陷的研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 467 | 现货 | |
5 mg | ¥ 1,070 | 现货 | |
10 mg | ¥ 1,650 | 现货 | |
25 mg | ¥ 2,760 | 现货 | |
50 mg | ¥ 3,980 | 现货 | |
100 mg | ¥ 5,630 | 现货 |
产品描述 | B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells., an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells., an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cells. |
靶点活性 | IRE1 Rnase:1230 nM |
体外活性 | B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM[1] and it also is highly effective in inhibiting splicing of XBP1 mRNA in human WaC3 cells and the expression of XBP-1s in LPS stimulated B cells[2]. Treatment of CLL cells with this inhibitor (B I09) mimick XBP-1 deficiency, including upregulation of IRE-1 expression and compromised BCR signaling. |
体内活性 | B I09 has a halflife of approximately 1.5 hours and reaches its peak concentration of approximately 39 μM in mouse plasma serum 15 minutes after administration. Administration of B I09 to CLL tumor-bearing mice suppress leukemic progression by inducing apoptosis. And it do not cause systemic toxicity[2]. |
分子量 | 303.31 |
分子式 | C16H17NO5 |
CAS No. | 1607803-67-7 |
Smiles | Oc1ccc2c3CCNCc3c(=O)oc2c1C1OCCCO1 |
密度 | 1.44 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | DMSO: 11 mg/mL (36.27 mM), Sonication is recommended. | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
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