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Targets Recommended: c-Kit c-Kit

174

抑制剂 & 化合物

5

天然产物

21

TargetMol 试剂盒

27

重组蛋白

8

同位素标记化合物

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Cat. No.	Product Name	Form	Specificity Of Inhibition
C0005	Cell Counting Kit-8 (CCK-8) Cell Counting Kit-8 (CCK-8)	Solution in bottle
C0120	Flag Tag Immunoprecipitation Kit Flag Tag 免疫沉淀试剂盒	Suspension in bottle	IP, Co-IP
C0117	Protein L Immunoprecipitation Kit Protein L 免疫沉淀试剂盒	Suspension in bottle	IP, Co-IP, ChIP
C0122	GFP Tag Immunoprecipitation Kit GFP Tag 免疫沉淀试剂盒	Suspension in bottle	IP, Co-IP
C0105	Protein A Immunoprecipitation Kit Protein A 免疫沉淀试剂盒	Suspension in bottle	IP, Co-IP, ChIP
C0119	MYC Tag Immunoprecipitation Kit MYC Tag 免疫沉淀试剂盒	Suspension in bottle	IP, Co-IP
C0116	Protein G Immunoprecipitation Kit Protein G 免疫沉淀试剂盒	Suspension in bottle	IP, Co-IP, ChIP
C0118	HA Tag Immunoprecipitation Kit HA Tag 免疫沉淀试剂盒	Suspension in bottle	IP, Co-IP
C0050	BCA Protein Quantification Kit BCA蛋白浓度测定试剂盒	Solution in bottle
C0121	GST Tag Immunoprecipitation Kit GST Tag 免疫沉淀试剂盒	Suspension in bottle	IP, Co-IP
C0099	Mag Beads NHS Kit (2 μm) NHS 磁珠试剂盒 (2 μm)	Suspension in bottle	体外诊断、免疫检测、细胞分选、免疫沉淀/共沉淀、蛋白/抗体分离纯化
C0104	Protein A/G Immunoprecipitation Kit Protein A/G 免疫沉淀试剂盒	Suspension in bottle	IP, Co-IP, ChIP
C0066	Human CD34+ Cell Enrichment Kit (positive selection) 人 CD34+ 细胞富集试剂盒 (阴选)	Suspension in bottle	适用于从人脐带血单个核细胞（CBMC）或外周血单个核细胞（PBMC）中富集 CD34+ 细胞。
C0067	Mouse CD4+ Cell Isolation Kit (positive selection) 小鼠 CD4+ 细胞分选试剂盒 (阳选)	Suspension in bottle	适用从小鼠淋巴器官，如脾脏和淋巴结中分选 CD4+ 细胞。
C0101	Magrose Beads NHS Kit (10-30 μm) NHS 琼脂糖磁珠试剂盒 (10-30 μm)	Suspension in bottle	体外诊断、免疫检测、细胞分选、免疫沉淀/共沉淀、蛋白/抗体分离纯化
C0068	Mouse CD8+ Cell Isolation Kit (positive selection) 小鼠 CD8+ 细胞分选试剂盒 (阳选)	Suspension in bottle	适用从小鼠淋巴器官，如脾脏和淋巴结中分选 CD4+ 细胞。
C0064	Mouse Neutrophil Cell Isolation Kit (negative selection) 小鼠中性粒细胞分选试剂盒 (阴选)	Suspension in bottle	适用于从小鼠骨髓细胞、小鼠脾脏细胞、小鼠外周血及其混合样本中中分选出中性粒细胞。
C0061	Mouse CD3+ T Cell Isolation Kit (negative selection) 小鼠 CD3+ T细胞分选试剂盒 (阴选)	Suspension in bottle	适用于从小鼠脾脏和淋巴结及其混合样本中分选出 CD3+ T 细胞。
C0065	Human CD3+ T Cell Isolation Kit (negative selection) 人 CD3+ T 细胞分选试剂盒 (阴选)	Suspension in bottle	适用于从人 PBMC 中分选出 CD3+ T 细胞。
C0062	Mouse CD4+ T Cell Isolation Kit (negative selection) 小鼠 CD4+ T细胞分选试剂盒 (阴选)	Suspension in bottle	适用于从小鼠脾脏和淋巴结及其混合样本中分选出 CD4+ T 细胞。
C0063	Mouse CD8+ T Cell Isolation Kit (negative selection) 小鼠 CD8+ T细胞分选试剂盒 (阴选)	Suspension in bottle	适用于从小鼠脾脏和淋巴结及其混合样本中分选出 CD8+ T 细胞。

TargetMol 试剂盒

Cell Counting Kit-8 (CCK-8)

Cat.No: C0005

Flag Tag 免疫沉淀试剂盒

Cat.No: C0120

Protein L 免疫沉淀试剂盒

Cat.No: C0117

GFP Tag 免疫沉淀试剂盒

Cat.No: C0122

Protein A 免疫沉淀试剂盒

Cat.No: C0105

MYC Tag 免疫沉淀试剂盒

Cat.No: C0119

Protein G 免疫沉淀试剂盒

Cat.No: C0116

HA Tag 免疫沉淀试剂盒

Cat.No: C0118

BCA蛋白浓度测定试剂盒

Cat.No: C0050

GST Tag 免疫沉淀试剂盒

Cat.No: C0121

NHS 磁珠试剂盒 (2 μm)

Cat.No: C0099

Protein A/G 免疫沉淀试剂盒

Cat.No: C0104

人 CD34+ 细胞富集试剂盒 (阴选)

Cat.No: C0066

小鼠 CD4+ 细胞分选试剂盒 (阳选)

Cat.No: C0067

NHS 琼脂糖磁珠试剂盒 (10-30 μm)

Cat.No: C0101

小鼠 CD8+ 细胞分选试剂盒 (阳选)

Cat.No: C0068

小鼠中性粒细胞分选试剂盒 (阴选)

Cat.No: C0064

小鼠 CD3+ T细胞分选试剂盒 (阴选)

Cat.No: C0061

人 CD3+ T 细胞分选试剂盒 (阴选)

Cat.No: C0065

小鼠 CD4+ T细胞分选试剂盒 (阴选)

Cat.No: C0062

小鼠 CD8+ T细胞分选试剂盒 (阴选)

Cat.No: C0063

Cat. No.	Product Name	Target	Signaling Pathways
T10651	c-Kit-IN-3	c-Kit	Tyrosine Kinase/Adaptors
	c-Kit-IN-3 是 c-KIT 激酶的特异性抑制剂，对 c-Kit (wt) 和 c-Kit (T670I) 的 IC50 分别为 4 nM、8 nM。
T4332	c-Kit-IN-1 PDGFR inhibitor 1,DCC-2618	c-Met/HGFR; c-Kit	Tyrosine Kinase/Adaptors
	c-Kit-IN-1 (DCC-2618) 是c-Kit 和c-Met 抑制剂(IC50<200 nM)。
T10801	CHMFL-ABL/KIT-155 CHMFL-ABL-KIT-155	c-Kit	Tyrosine Kinase/Adaptors
	CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis.
T22256	c-Kit-IN-5-1 3-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one,AMG-25,3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one	c-Kit	Tyrosine Kinase/Adaptors
	c-Kit-IN-5-1 (AMG-25) 是一种新型的、高效的、选择性的 c-Kit 抑制剂。
T10650	c-Kit-IN-2	c-Kit	Tyrosine Kinase/Adaptors
	c-Kit-IN-2 is a c-KIT inhibitor (IC50: 82 nM), shows superior antiproliferative activities against all the three GIST cell lines, GIST430, GIST882, and GIST48 (GI50s: 1, 3, and 2 nM).
T19222	c-Kit-IN-3 maleate	Others	Others
	c-Kit-IN-3 maleate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I).
T19220	c-Kit-IN-3 hydrochloride	Others	Others
	c-Kit-IN-3 hydrochloride is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I).
T19223	c-Kit-IN-3 tartrate	Others	Others
	c-Kit-IN-3 tartrate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I).
T19221	c-Kit-IN-3 L-tartrate	Others	Others
	c-Kit-IN-3 L-tartrate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I).
T19219	c-Kit-IN-3 D-tartrate	Others	Others
	c-Kit-IN-3 D-tartrate is a potent and selective c-KIT kinase inhibitor (IC50s: 4 nM, 8 nM for c-KIT wt, and c-KIT T670I).
T3452	ISCK03	c-Kit	Tyrosine Kinase/Adaptors
	ISCK03 是一种特异性的 SCF/c-Kit 抑制剂。
T22349	JNJ-38158471 CS-2660	VEGFR; c-RET; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	JNJ-38158471 (CS-2660) 是一种耐受性好的，有口服活性的、高效的、选择性的 VEGFR-2抑制剂 (IC50:40 nM)，还能抑制 Ret (IC50:180 nM) 和 Kit (IC50:500 nM)。
T5409	AZD3229	c-Kit	Tyrosine Kinase/Adaptors
	AZD3229 是一种突变型酪氨酸激酶受体抑制剂，可用于胃肠道间质瘤的研究。
T41003	KG5	Raf; FLT; PDGFR; c-Kit	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	KG5 是 PDGFRβ 和 B-Raf 的双重变构抑制剂，对 PDGFRβ 和 PDGFRα 的 Kd 分别为 520 nM 和 300 nM。 KG5 抑制 FLT3、KIT 和 c-Raf，具有抗癌和抗血管生成活性。
T9689	M4205	c-Kit	Tyrosine Kinase/Adaptors
	M4205 是一种 c-Kit 抑制剂，对外显子 11、13、17 中的 c-Kit 突变具有高活性。
T4320	Flumatinib HHGV678	Bcr-Abl; PDGFR; c-Kit	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Flumatinib (HHGV678) 是一种具有口服活性的选择性 Bcr-Abl 抑制剂，能够作用于 c-Abl (IC50:1.2 nM)，PDGFRβ (IC50:307.6 nM) 和 c-Kit (IC50:665.5 nM)。
T5109	Avapritinib BLU-285	PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Avapritinib (BLU-285) 是选择性的、高效的、具有口服活性的 KIT 和 PDGFRA 激活环突变激酶抑制剂，能够作用于 KIT D816V (IC50:0.27 nM) 和 PDGFRA D842V (IC50:0.24 nM)。它减弱 ABCB1 和 ABCG2 的传输功能。它与激酶的活性构象结合，并显示抗肿瘤活性。
T7945	SU14813	VEGFR; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	SU14813 是一种多靶点受体酪氨酸激酶抑制剂，能够抑制 VEGFR2 (IC50:50 nM)，VEGFR1 (IC50:2 nM)，PDGFRβ (IC50:4 nM)，KIT (IC50:15 nM)。
T6166	Telatinib Bay 57-9352,替拉替尼	VEGFR; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Telatinib (Bay 57-9352) 是一种口服具有活力的，小分子的 VEGFR2，VEGFR3，PDGFα 和 c-Kit 抑制剂，它们的 IC50 值分别为6，4，15，1 nM。
T2288	Motesanib AMG 706,莫特塞尼,莫替沙尼	VEGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Motesanib (AMG 706) 是有效的、ATP 竞争性的 VEGFR1/2/3 的抑制剂，其IC50值为 2 nM/3 nM/6 nM，与对 Kit 的选择性相似，是 PDGFR 和 Ret 的 10 倍多。
T10652	Vimseltinib DCC-3014	c-Fms; CSF-1R; c-Kit	Tyrosine Kinase/Adaptors
	Vimseltinib (DCC-3014) 是 c-FMS(CSF-IR) 和 c-Kit 抑制剂，IC50值分别为 <0.01 μM 和 0.1-1 μM。
T4349	Sitravatinib MG516,MGCD516	Discoidin Domain Receptor (DDR); VEGFR; FLT; Trk receptor; TAM Receptor; c-Kit; Ephrin Receptor	Angiogenesis; Tyrosine Kinase/Adaptors
	Sitravatinib (MGCD516) 是一种有口服活性的受体酪氨酸激酶抑制剂。它单独使用即具有有效的抗肿瘤功效，且通过促进抗肿瘤免疫微环境增强了 PD-1 阻断的活性。
TQ0235	AC710	FLT; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	AC710是一种 PDGFR 抑制剂，能够作用于 FLT3 (Kd:0.6)，CSF1R (Kd:1.57)，KIT (Kd:1)，PDGFRα (Kd:1.3) 和 PDGFRβ (Kd:1.0)。
T2115	Pexidartinib PLX-3397	Apoptosis; c-Fms; FLT; CSF-1R; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Pexidartinib (PLX-3397) 是一种 CSF-1R 和 c-Kit 的抑制剂 (IC50=20/10 nM)，具有选择性、ATP 竞争性和口服活性。Pexidartinib 具有抗肿瘤活性，可以诱导细胞凋亡。
T1836	AZD2932	VEGFR; FLT; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	AZD2932是一种多靶点激酶抑制剂，细胞试验中能够抑制 VEGFR2 (IC50:8 nM)，PDGFβ (IC50:4 nM)，PDGFβ (IC50:7 nM) 和 PDGFβ (IC50:9 nM)。
T13178	Toceranib 托西尼布,PHA 291639E,SU11654	VEGFR; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Toceranib (PHA 291639E) 是口服具有活力的受体酪氨酸激酶 (RTK) 抑制剂，能有效抑制PDGFR，VEGFR，Kit，抑制 PDGFRβ 和 Flk-1/KDR 的Ki 分别为 5 nM 和 6 nM。它具有抗肿瘤和抗血管生成作用，用于研究犬肥大细胞肿瘤。
T2288L	Motesanib Diphosphate Motesanib,AMG 706,二磷酸莫替沙尼	VEGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Motesanib Diphosphate (AMG 706) 是一种有效的VEGFR1/2/3的 ATP 竞争性抑制剂，IC50值为 2 nM/3 nM/6 nM，与对 Kit 的选择性相似，是 PDGFR 和 Ret 的 10 倍多。
T0520	Lenvatinib 仑伐替尼,E7080	VEGFR; FGFR; c-RET; PDGFR; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Lenvatinib (E7080) 是一种多靶点受体酪氨酸激酶抑制剂，抑制 VEGFR1-3、FGFR1-4、KIT、PDGFR 和 RET 等，具有口服活性。Lenvatinib 对 VEGFR2 和 VEGFR3 的抑制活性最强 (IC50=4/5.2 nM)。Lenvatinib 具有强效抗肿瘤活性。
T0097L	Pazopanib 帕唑帕尼,GW786034	VEGFR; FGFR; PDGFR; c-Kit; Autophagy	Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
	Pazopanib (GW786034) 是一种小分子抑制剂，可抑制多种具有潜在抗肿瘤活性的蛋白酪氨酸激酶。它抑制VEGFR1、VEGFR2、VEGFR3、PDGFRβ、c-Kit、FGFR1和c-Fms 的IC50分别为10、30、47、84、74、140和146 nM。
T4191	Multi-kinase inhibitor 1 Multi-kinase inhibitor I	Others; Bcr-Abl; PDGFR; c-Kit	Angiogenesis; Cytoskeletal Signaling; Others; Tyrosine Kinase/Adaptors
	Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) 是多激酶抑制剂。它有用于导致与酪氨酸激酶活性异常或失控有关的疾病或失调的潜力，特别是与c-Kit，PDGF-R，Bcr-abl 活性相关的疾病。
T8482	Ripretinib DCC-2618,瑞普替尼	Apoptosis; VEGFR; FLT; PDGFR; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Ripretinib (DCC-2618) 是一种口服生物利用的，选择性 KIT 和 PDGFRA 开关控制抑制剂，具有抗肿瘤作用并诱导细胞凋亡。它专门针对 KIT 和 PDGFRA 的野生型和突变型并与之结合在其开关口袋结合位点，从而防止这些激酶从无活性构象转变为有活性构象，并使它们的野生型和突变体形式失活。
T2624	OSI-930 OSI 930,噻尔非尼	Apoptosis; c-Fms; Raf; VEGFR; FLT; CSF-1R; Src; c-Kit	Angiogenesis; Apoptosis; MAPK; Tyrosine Kinase/Adaptors
	OSI-930 是 Kit，KDR 和 CSF-1R (c-Fms)的口服选择性抑制剂，IC50分别为 80 nM，9 nM 和 15 nM。它具有抗肿瘤活性，靶向肿瘤中的癌细胞增殖和血管生成。它还适度抑制 Flt-1，c-Raf 和 Lck，并且对 PDGFRα/β，Flt-3和 Abl 具有较弱的抑制活性。
T11641	N-Desmethyl imatinib Imatinib metabolite N-Desmethyl imatinib,Norimatinib,N-去甲基伊马替尼	Bcr-Abl; PDGFR; c-Kit; Drug Metabolite	Angiogenesis; Cytoskeletal Signaling; Metabolism; Tyrosine Kinase/Adaptors
	N-Desmethyl imatinib (Imatinib metabolite N-Desmethyl imatinib) 是 Imatinib 的代谢物。Imatinib 是一个靶向 c-Kit、v-Abl 和 PDGFR 的多靶点抑制剂。
T2609	Masitinib AB1010,马赛替尼	Apoptosis; FAK; c-Fms; FGFR; Bcr-Abl; PDGFR; Src; c-Kit; Hck	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Masitinib (AB1010) 是生物口服可利用的选择性 c-Kit 抑制剂 (对于人重组c-Kit，IC50=200 nM)，它还抑制PDGFRα/β(IC50s=540/800 nM)，Lyn(对 LynB 的IC50=510 nM)，Lck，较小程度上抑制FGFR3和FAK。它有抗增殖，促凋亡活性，且毒性低。
T6230	Imatinib 伊马替尼,STI571,CGP057148B,ST-1571	SARS-CoV; Bcr-Abl; PDGFR; c-Kit; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Imatinib (STI571) 是一种多靶点受体酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL、v-Abl、PDGFR、c-kit 等激酶活性，具有口服活性。Imatinib 具有抗肿瘤活性，可用于治疗慢性粒细胞白血病。
T2051	SKLB4771 FLT3-IN-1,FLT3-IN-1	FLT	Angiogenesis; Tyrosine Kinase/Adaptors
	SKLB4771 (FLT3-IN-1) 是一种新型的、高效的 Flt3 抑制剂 (IC50:10nM)。
T8541	Lenvatinib mesylate 仑伐替尼甲酸盐,E7080 (mesylate),乐伐替尼	VEGFR; FGFR; c-RET; PDGFR; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Lenvatinib mesylate (E7080 (mesylate)) 是一种口服具有活力的，多靶点酪氨酸激酶抑制剂，能够抑制血管内皮生长因子受体(VEGFR1-3)，成纤维细胞生长因子受体(FGFR1-4)，干细胞因子受体(KIT)，血小板衍生生长因子受体(PDGFR)，转染期间重排(RET)，具有效抗癌作用。
T4053	AST 487 NVP-AST 487	VEGFR; FLT; c-RET; Bcr-Abl; c-Kit	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	AST 487 (NVP-AST 487) 是 RET 激酶抑制剂 (IC50:880 nM)，能够抑制 RET 自磷酸化，及下游效应器激活，也抑制 Flt-3 (IC50:520 nM)。
T2516	Amuvatinib MP470,HPK 56	Apoptosis; FLT; c-Met/HGFR; c-RET; DNA/RNA Synthesis; PDGFR; c-Kit	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Tyrosine Kinase/Adaptors
	Amuvatinib (MP470) 是一种多靶点酪氨酸激酶抑制剂，对突变 c-Kit，PDGFRα，Flt3，c-Met 和 c-Ret 具有活性。它还是一种 DNA 修复抑制剂，靶向蛋白 DNA 修复 RAD51，从而破坏 DNA 损伤修复，具有抗肿瘤活性。
T7861	Flumatinib mesylate 甲磺酸氟马替尼/氟马替尼,HHGV678 mesylate,甲磺酸氟马替尼	Bcr-Abl; PDGFR; c-Kit	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Flumatinib mesylate (HHGV678 mesylate) 是一种具有口服活性的选择性Bcr-Abl 抑制剂，能够作用于 c-Abl (IC50:1.2 nM)，PDGFRβ (IC50:307.6 nM) 和 c-Kit (IC50:665.5 nM)。
T35570	Chiauranib CS2164,西奥罗尼	c-Fms; VEGFR; FLT; PDGFR; c-Kit; Aurora Kinase	Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
	Chiauranib 是一种针对肿瘤血管生成的多靶点抑制剂，具有强大的抗癌作用。 Chiauranib 有效抑制血管生成相关激酶（VEGFR1、VEGFR2、VEGFR3、PDGFRα 和 c-Kit）、有丝分裂相关激酶 Aurora B 和慢性炎症相关激酶 CSF1R，IC50 值范围为 1-9 nM。
T8544	Masitinib mesylate 甲磺酸马赛替尼,AB-1010 mesylate,马赛替尼	Apoptosis; FAK; FGFR; PDGFR; Src; c-Kit	Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Masitinib mesylate (AB-1010 mesylate) 是一种生物口服可利用的选择性 c-Kit 抑制剂，IC50 为 200 nM。它还抑制 PDGFRα/β，IC50值为540/800 nM，对 LynB 的 IC50为510 nM。它的毒性低，有抗增殖和促凋亡活性。
T1925	PLX647	c-Fms; c-Kit	Tyrosine Kinase/Adaptors
	PLX647 是具有口服活性的、高效的、特异性的FMS 和KIT 双激酶抑制剂，IC50分别为 28 和 16 nM。它 (1 μM) 在 400 个激酶组中显示出对 FMS 和 KIT 有选择性，但 FLT3 和 KDR 除外 (IC50=91 和 130 nM)。
T1621	Imatinib Mesylate 甲磺酸伊马替尼,ST-1571 Mesylate,STI-571,CGP-57148B	Bcr-Abl; PDGFR; c-Kit; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Imatinib Mesylate (STI571 Mesylate) 是一种多靶点受体酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL、v-Abl、PDGFR、c-kit 等激酶活性，具有口服活性。Imatinib Mesylate 具有抗肿瘤活性，可用于治疗慢性粒细胞白血病。
T6711	Tyrphostin AG1296 Tyrphostin AG 1296,AG 1296	Apoptosis; FGFR; FLT; PDGFR; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Tyrphostin AG1296 (Tyrphostin AG 1296) 抑制人PDGF α和β受体以及相关干细胞因子受体的信号传导，是一种选择性血小板衍生生长因子受体抑制剂，IC50值为 0.8 μM。
T7394	Toceranib Phosphate SU11654 phosphate,PHA 291639 phosphate,托西尼布磷酸盐	VEGFR; Tyrosinase; PDGFR; c-Kit	Angiogenesis; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Toceranib Phosphate (SU11654 phosphate) 是有效的、具有口服活性的酪氨酸激酶 (RTK) 受体抑制剂，能抑制PDGFR，VEGFR，Kit，抑制 PDGFRβ 和 Flk-1/KDR 的Ki 分别为 5 nM 和 6 nM。它具有抗肿瘤和抗血管生成作用，可用于研究犬肥大细胞肿瘤。
T2586	Cabozantinib 卡博替尼,XL184,BMS-907351	Apoptosis; VEGFR; FLT; c-Met/HGFR; c-RET; TAM Receptor; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Cabozantinib (XL184) 是一种多靶点酪氨酸激酶受体抑制剂，可以抑制 VEGFR2、c-Met、Kit、Axl 和 Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM)。Cabozantinib 具有抗肿瘤和抗血管生成活性。
T1792	Regorafenib BAY 73-4506,瑞戈非尼,Fluoro-Sorafenib,瑞格非尼	Raf; VEGFR; c-RET; PDGFR; c-Kit; Autophagy	Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine Kinase/Adaptors
	Regorafenib (BAY 73-4506) 是一种多靶点受体酪氨酸激酶抑制剂，抑制 RET、C-RAF、VEGFR2、c-Kit、VEGFR1 和 PDGFRβ (IC50=1.5/2.5/4.2/7/13/22 nM)，具有口服活性。Regorafenib 具有抗肿瘤和抗血管生成活性。
T4315	Ki20227 N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲	c-Fms; VEGFR; CSF-1R; PDGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Ki20227 是一种高效的、口服具有活性的、选择性的CSF1R(c-Fms 酪氨酸激酶)抑制剂，对 CSF1R，VEGFR2，c-Kit 和PDGFRβ的IC50分别为 2 nM，12 nM，451 nM 和 217 nM。它可以阻止破骨细胞分化和溶骨性破坏。
T1667	Tandutinib MLN518,CT53518,NSC726292,坦度替尼	Apoptosis; FLT; CSF-1R; PDGFR; Src; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Tandutinib (CT53518) 是一种选择性 FLT3抑制剂，其 IC50为 0.22 μM。它还抑制c-Kit 和PDGFR，其IC50分别为 0.17 μM 和 0.20 μM。它可穿透血脑屏障，用于急性骨髓性白血病。

化合物

Cat.No: T10651

Target: c-Kit

Cat.No: T4332

Synonym: PDGFR inhibitor 1,DCC-2618

Target: c-Met/HGFR, c-Kit

CHMFL-ABL/KIT-155

Cat.No: T10801

Synonym: CHMFL-ABL-KIT-155

Target: c-Kit

Cat.No: T22256

Synonym: 3-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one,AMG-25,3-(2-aminoquinazolin-6-yl)-4-methyl-1-[4-(1,3-oxazol-2-yl)phenyl]pyridin-2-one

Target: c-Kit

Cat.No: T10650

Target: c-Kit

c-Kit-IN-3 maleate

Cat.No: T19222

Target: Others

c-Kit-IN-3 hydrochloride

Cat.No: T19220

Target: Others

c-Kit-IN-3 tartrate

Cat.No: T19223

Target: Others

c-Kit-IN-3 L-tartrate

Cat.No: T19221

Target: Others

c-Kit-IN-3 D-tartrate

Cat.No: T19219

Target: Others

Cat.No: T3452

Target: c-Kit

Cat.No: T22349

Synonym: CS-2660

Target: VEGFR, c-RET, c-Kit

Cat.No: T5409

Target: c-Kit

Cat.No: T41003

Target: Raf, FLT, PDGFR, c-Kit

Cat.No: T9689

Target: c-Kit

Cat.No: T4320

Synonym: HHGV678

Target: Bcr-Abl, PDGFR, c-Kit

Cat.No: T5109

Synonym: BLU-285

Target: PDGFR, c-Kit

Cat.No: T7945

Target: VEGFR, PDGFR, c-Kit

Cat.No: T6166

Synonym: Bay 57-9352,替拉替尼

Target: VEGFR, PDGFR, c-Kit

Cat.No: T2288

Synonym: AMG 706,莫特塞尼,莫替沙尼

Target: VEGFR, c-Kit

Cat.No: T10652

Synonym: DCC-3014

Target: c-Fms, CSF-1R, c-Kit

Cat.No: T4349

Synonym: MG516,MGCD516

Target: Discoidin Domain Receptor (DDR), VEGFR, FLT, Trk receptor, TAM Receptor, c-Kit, Ephrin Receptor

Cat.No: TQ0235

Target: FLT, PDGFR, c-Kit

Cat.No: T2115

Synonym: PLX-3397

Target: Apoptosis, c-Fms, FLT, CSF-1R, c-Kit

Cat.No: T1836

Target: VEGFR, FLT, PDGFR, c-Kit

Cat.No: T13178

Synonym: 托西尼布,PHA 291639E,SU11654

Target: VEGFR, PDGFR, c-Kit

Motesanib Diphosphate

Cat.No: T2288L

Synonym: Motesanib,AMG 706,二磷酸莫替沙尼

Target: VEGFR, c-Kit

Cat.No: T0520

Synonym: 仑伐替尼,E7080

Target: VEGFR, FGFR, c-RET, PDGFR, c-Kit

Cat.No: T0097L

Synonym: 帕唑帕尼,GW786034

Target: VEGFR, FGFR, PDGFR, c-Kit, Autophagy

Multi-kinase inhibitor 1

Cat.No: T4191

Synonym: Multi-kinase inhibitor I

Target: Others, Bcr-Abl, PDGFR, c-Kit

Cat.No: T8482

Synonym: DCC-2618,瑞普替尼

Target: Apoptosis, VEGFR, FLT, PDGFR, c-Kit

Cat.No: T2624

Synonym: OSI 930,噻尔非尼

Target: Apoptosis, c-Fms, Raf, VEGFR, FLT, CSF-1R, Src, c-Kit

N-Desmethyl imatinib

Cat.No: T11641

Synonym: Imatinib metabolite N-Desmethyl imatinib,Norimatinib,N-去甲基伊马替尼

Target: Bcr-Abl, PDGFR, c-Kit, Drug Metabolite

Cat.No: T2609

Synonym: AB1010,马赛替尼

Target: Apoptosis, FAK, c-Fms, FGFR, Bcr-Abl, PDGFR, Src, c-Kit, Hck

Cat.No: T6230

Synonym: 伊马替尼,STI571,CGP057148B,ST-1571

Target: SARS-CoV, Bcr-Abl, PDGFR, c-Kit, Autophagy

Cat.No: T2051

Synonym: FLT3-IN-1,FLT3-IN-1

Target: FLT

Lenvatinib mesylate

Cat.No: T8541

Synonym: 仑伐替尼甲酸盐,E7080 (mesylate),乐伐替尼

Target: VEGFR, FGFR, c-RET, PDGFR, c-Kit

Cat.No: T4053

Synonym: NVP-AST 487

Target: VEGFR, FLT, c-RET, Bcr-Abl, c-Kit

Cat.No: T2516

Synonym: MP470,HPK 56

Target: Apoptosis, FLT, c-Met/HGFR, c-RET, DNA/RNA Synthesis, PDGFR, c-Kit

Flumatinib mesylate

Cat.No: T7861

Synonym: 甲磺酸氟马替尼/氟马替尼,HHGV678 mesylate,甲磺酸氟马替尼

Target: Bcr-Abl, PDGFR, c-Kit

Cat.No: T35570

Synonym: CS2164,西奥罗尼

Target: c-Fms, VEGFR, FLT, PDGFR, c-Kit, Aurora Kinase

Masitinib mesylate

Cat.No: T8544

Synonym: 甲磺酸马赛替尼,AB-1010 mesylate,马赛替尼

Target: Apoptosis, FAK, FGFR, PDGFR, Src, c-Kit

Cat.No: T1925

Target: c-Fms, c-Kit

Imatinib Mesylate

Cat.No: T1621

Synonym: 甲磺酸伊马替尼,ST-1571 Mesylate,STI-571,CGP-57148B

Target: Bcr-Abl, PDGFR, c-Kit, Autophagy

Tyrphostin AG1296

Cat.No: T6711

Synonym: Tyrphostin AG 1296,AG 1296

Target: Apoptosis, FGFR, FLT, PDGFR, c-Kit

Toceranib Phosphate

Cat.No: T7394

Synonym: SU11654 phosphate,PHA 291639 phosphate,托西尼布磷酸盐

Target: VEGFR, Tyrosinase, PDGFR, c-Kit

Cat.No: T2586

Synonym: 卡博替尼,XL184,BMS-907351

Target: Apoptosis, VEGFR, FLT, c-Met/HGFR, c-RET, TAM Receptor, c-Kit

Cat.No: T1792

Synonym: BAY 73-4506,瑞戈非尼,Fluoro-Sorafenib,瑞格非尼

Target: Raf, VEGFR, c-RET, PDGFR, c-Kit, Autophagy

Cat.No: T4315

Synonym: N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-2-甲氧基苯基]-N'-[1-(2-噻唑基)乙基]脲

Target: c-Fms, VEGFR, CSF-1R, PDGFR, c-Kit

Cat.No: T1667

Synonym: MLN518,CT53518,NSC726292,坦度替尼

Target: Apoptosis, FLT, CSF-1R, PDGFR, Src, c-Kit

Cat. No.	Product Name	Target	Signaling Pathways
T3717	Hinokitiol 4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇	DNA Methyltransferase; Virus Protease; Estrogen/progestogen Receptor; Nrf2	Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology
	Hinokitiol (4-Isopropyltropolone) 是从日本扁柏中分离到的一种挥发油成分，可抑制紫外线 B 诱导的角质形成细胞凋亡，可调节雌激素受体信号传导并抑制人乳腺癌细胞的增殖。它具有抗感染、抗氧化及抗肿瘤等活性。
T20779	Kitasamycin tartrate Leucomycin tartrate	Others	Others
	Kitasamycin tartrate, a macrolide antibiotic produced by Streptomyces kitasatoensis, has a wide spectrum of antimicrobial activity.
TN6655	(1S,2S)-threo-Honokitriol
	(1S,2S)-threo-Honokitriol是一种天然产物，属于木兰科木兰属，其产品编号为 TN6655，CAS号为 1099687-80-5。(1S,2S)-threo-Honokitriol可用作对照参考。
T6943	Picropodophyllin AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素	Apoptosis; IGF-1R	Apoptosis; Tyrosine Kinase/Adaptors
	Picropodophyllin (Picropodophyllin (PPP)) 是一种选择性的胰岛素样生长因子-1受体抑制剂，IC50为1 nM。
T3S0027	Picropodophyllotoxin AXL 1717,Picropodophyllin,苦鬼臼毒素	IGF-1R	Tyrosine Kinase/Adaptors
	Picropodophyllotoxin (AXL 1717) 是一种环木脂素生物碱，存在于五月树(Podophyllum peltatum) 中，是一种具有潜在抗肿瘤活性的胰岛素样生长因子 1 受体 (IGF1R) 的小分子抑制剂。它特异性抑制 IGF1R 的活性并下调细胞表达，而不干扰其他生长因子受体的活性，例如胰岛素受体、表皮生长因子、血小板衍生生长因子、成纤维细胞生长因子和肥大/干细胞生长因子 (KIT) ）。该药剂在抑制肿瘤细胞增殖和诱导肿瘤细胞凋亡方面显示出有效的活性。 IGF1R 是一种在多种人类癌症中过度表达的受体酪氨酸激酶，在多种癌细胞的生长和存活中起关键作用。

天然产物

Cat.No: T3717

Synonym: 4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇

Target: DNA Methyltransferase, Virus Protease, Estrogen/progestogen Receptor, Nrf2

Kitasamycin tartrate

Cat.No: T20779

Synonym: Leucomycin tartrate

Target: Others

(1S,2S)-threo-Honokitriol

Cat.No: TN6655

Picropodophyllin

Cat.No: T6943

Synonym: AXL1717,苦鬼臼脂素,Picropodophyllin (PPP),Picropodophyllotoxin,PPP,苦鬼臼毒素

Target: Apoptosis, IGF-1R

Picropodophyllotoxin

Cat.No: T3S0027

Synonym: AXL 1717,Picropodophyllin,苦鬼臼毒素

Target: IGF-1R

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01802	c-Kit Protein, Mouse, Recombinant (His) SCO5,SCO1,Bs,Gsfsco1,v-kit Hardy-Zuckerman 4 feline...	Mouse	HEK293 Cells
	c-Kit Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57 kDa and the accession number is P05532-1.
TMPY-04051	c-Kit Protein, Human, Recombinant (hFc) SCFR,v-kit Hardy-Zuckerman 4 feline sarcoma viral o...	Human	HEK293 Cells
	c-Kit Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82 kDa and the accession number is P10721-2.
TMPY-01935	c-Kit Protein, Human, Recombinant (His) PBT,CD117,v-kit Hardy-Zuckerman 4 feline sarcoma vi...	Human	HEK293 Cells
	c-Kit Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.7 kDa and the accession number is P10721-2.
TMPY-05655	c-Kit Protein, Rhesus, Recombinant (hFc) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge...	Rhesus	HEK293 Cells
	c-Kit Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.3 kDa and the accession number is A0A8J8YKB5.
TMPJ-01470	SCF Protein, Human, Recombinant Mast Cell Growth Factor,c-Kit ligand,KITLG...	Human	E. coli
	Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors.
TMPY-02170	SCF Protein, Human, Recombinant (aa 1-189, His) DCUA,Kitl,FPHH,SCF,KL-1,SF,FPH2,MGF,SHEP7,C-kit...	Human	Baculovirus Insect Cells
	SCF Protein, Human, Recombinant (aa 1-189, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.9 kDa and the accession number is P21583-1.
TMPY-01801	c-Kit Protein, Mouse, Recombinant (hFc) SCO1,Gsfsco1,W,v-kit Hardy-Zuckerman 4 feline sarco...	Mouse	HEK293 Cells
	c-Kit Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.5 kDa and the accession number is P05532-1.
TMPY-02105	SCF Protein, Mouse, Recombinant (His) Gb,Kitlg,SF,Clo,Mgf,SLF,Sl,KIT ligand,SCF,...	Mouse	Baculovirus Insect Cells
	SCF Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is P20826-1.
TMPY-06656	c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated CD117,SCFR,C-Kit,v-kit Hardy-Zuckerman 4 f...	Human	HEK293 Cells
	c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 58.50 kDa and the accession number is P10721-2.
TMPY-03567	c-Kit Protein, Human, Recombinant (aa 50-190, His) SCFR,PBT,C-Kit,CD117,v-kit Hardy-Zuckerman...	Human	E. coli
	c-Kit Protein, Human, Recombinant (aa 50-190, His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.9 kDa and the accession number is P10721-1.
TMPY-04564	c-Kit Protein, Human, Recombinant (aa 540-972, His & GST) C-Kit,PBT,SCFR,CD117,v-kit Hardy-Zuckerman...	Human	Baculovirus Insect Cells
	c-Kit Protein, Human, Recombinant (aa 540-972, His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 76.8 kDa and the accession number is P10721-2.
TMPY-03034	c-Kit Protein, Rat, Recombinant (hFc) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge...	Rat	HEK293 Cells
	c-Kit Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.4 kDa and the accession number is Q63116.
TMPY-03136	c-Kit Protein, Rat, Recombinant (His) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge...	Rat	HEK293 Cells
	c-Kit Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.9 kDa and the accession number is Q63116.
TMPY-06652	c-Kit Protein, Rhesus, Recombinant (His) v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge...	Rhesus	HEK293 Cells
	c-Kit Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57 kDa and the accession number is NP_001253024.1.
TMPJ-00166	SCF Protein, Mouse, Recombinant SCF,Hematopoietic growth factor KL,MGF,Steel factor,Mast cel...	Mouse	E. coli
	Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the ...
TMPK-00777	CD117 Protein, Mouse, Recombinant (His) ckit,PBT,SCFR,KIT,CD117,c-kit	Mouse	HEK293 Cells
	The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and megakaryocytic cell lineages. CD117 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 56.63 kDa and the accession number is P05...
TMPK-01270	CD117 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) KIT,PBT,c-kit,CD117,SCFR,ckit	Cynomolgus,Rhesus	HEK293 Cells
	The c-kit proto-oncogen (CD117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and megakaryocytic cell lineages.
TMPJ-00402	CD117 Protein, Human, Recombinant (hFc) KIT,CD117,v-kit Hardy-Zuckerman 4 feline s...	Human	HEK293 Cells
	C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily and CSF-1/PDGF receptor subfamily. SCF R expression on mast cells enables them to infiltrate SCF-secreting tumors where they promote tumor growth and induce local immune suppression. SCF R is up-regulated on dendritic cells by Th2-orTh17-biasing sti...
TMPK-00805	CD117 Protein, Human, Recombinant (His & Avi), Biotinylated CD117,EC 2.7.10,EC 2.7.10.1,c-kit,KIT,SCFR...	Human	HEK293 Cells
	The c-kit proto-oncogen (CD 117) has been shown to be present in several cell types including normal and neoplastic hemopoietic cells. Among normal BM cells, CD117 expression has been found in about half of the CD34 precursors including progenitors committed to the erythroid, granulo-monocytic, and megakaryocytic cell lineages. CD117 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 58.60 kDa and the...
TMPJ-00895	SCF Protein, Rat, Recombinant (HEK293, His) steel factor,Mast cell growth factor,SLF,MGFSHEP7,SCFStem ce...	Rat	HEK293 Cells
	SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. In phase I/II...
TMPY-05135	SCF Protein, Mouse, Recombinant (His), Biotinylated Con,SLF,SF,Mgf,Gb,Clo,KIT ligand,Sl,Kitlg,...	Mouse	Baculovirus Insect Cells
	SCF Protein, Mouse, Recombinant (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 19.7 kDa and the accession number is P20826-1.
TMPJ-00894	SCF Protein, Rat, Recombinant (His) Hematopoietic growth factor KL,Steel factor,Stem cell factor...	Rat	E. coli
	Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase...
TMPH-02352	Influenza A H3N2 (strain A/Kitakyushu/159/1993) Nucleoprotein/NP Protein (His) Nucleocapsid protein,NP,Nucleoprotein	H3N2	E. coli
	Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathw...
TMPY-03968	Secretogranin II Protein, Human, Recombinant (His) EM66,SgII,SN,CHGC,secretogranin II	Human	HEK293 Cells
	Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KITL / kit ligand also belongs to the family of dimeric transmembrane growth factors. The soluble form of KIT ligand is a secreted protein. Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell devel...
TMPY-04391	Lyn Protein, Human, Recombinant (GST) JTK8,LYN proto-oncogene, Src family tyrosine kinase,p56Lyn,p...	Human	Baculovirus Insect Cells
	Tyrosine-protein kinase Lyn is a member of the Src family of protein tyrosine kinases, which is mainly expressed in hematopoietic cells, in neural tissues liver, and adipose tissue. Tyrosine-protein kinase Lyn has many functions. Lyn kinase may downregulate the expression of stem cell growth factor receptor (KIT). Lyn kinase Acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between prolif...
TMPY-02240	STAT1 Protein, Human, Recombinant (His & GST) IMD31A,IMD31B,IMD31C,STAT91,CANDF7,signal transducer and act...	Human	Baculovirus Insect Cells
	STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands, including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. It is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs),...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His) MAP kinase isoform p44,p44-ERK1,MAPK3,Extracellular signal-r...	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...

重组蛋白

c-Kit Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01802

Species: Mouse

Expression System: HEK293 Cells

c-Kit Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04051

Species: Human

Expression System: HEK293 Cells

c-Kit Protein, Human, Recombinant (His)

Cat.No: TMPY-01935

Species: Human

Expression System: HEK293 Cells

c-Kit Protein, Rhesus, Recombinant (hFc)

Cat.No: TMPY-05655

Species: Rhesus

Expression System: HEK293 Cells

SCF Protein, Human, Recombinant

Cat.No: TMPJ-01470

Species: Human

Expression System: E. coli

SCF Protein, Human, Recombinant (aa 1-189, His)

Cat.No: TMPY-02170

Species: Human

Expression System: Baculovirus Insect Cells

c-Kit Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-01801

Species: Mouse

Expression System: HEK293 Cells

SCF Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02105

Species: Mouse

Expression System: Baculovirus Insect Cells

c-Kit Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-06656

Species: Human

Expression System: HEK293 Cells

c-Kit Protein, Human, Recombinant (aa 50-190, His)

Cat.No: TMPY-03567

Species: Human

Expression System: E. coli

c-Kit Protein, Human, Recombinant (aa 540-972, His & GST)

Cat.No: TMPY-04564

Species: Human

Expression System: Baculovirus Insect Cells

c-Kit Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-03034

Species: Rat

Expression System: HEK293 Cells

c-Kit Protein, Rat, Recombinant (His)

Cat.No: TMPY-03136

Species: Rat

Expression System: HEK293 Cells

c-Kit Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-06652

Species: Rhesus

Expression System: HEK293 Cells

SCF Protein, Mouse, Recombinant

Cat.No: TMPJ-00166

Species: Mouse

Expression System: E. coli

CD117 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00777

Species: Mouse

Expression System: HEK293 Cells

CD117 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)

Cat.No: TMPK-01270

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

CD117 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00402

Species: Human

Expression System: HEK293 Cells

CD117 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00805

Species: Human

Expression System: HEK293 Cells

SCF Protein, Rat, Recombinant (HEK293, His)

Cat.No: TMPJ-00895

Species: Rat

Expression System: HEK293 Cells

SCF Protein, Mouse, Recombinant (His), Biotinylated

Cat.No: TMPY-05135

Species: Mouse

Expression System: Baculovirus Insect Cells

SCF Protein, Rat, Recombinant (His)

Cat.No: TMPJ-00894

Species: Rat

Expression System: E. coli

Influenza A H3N2 (strain A/Kitakyushu/159/1993) Nucleoprotein/NP Protein (His)

Cat.No: TMPH-02352

Species: H3N2

Expression System: E. coli

Secretogranin II Protein, Human, Recombinant (His)

Cat.No: TMPY-03968

Species: Human

Expression System: HEK293 Cells

Lyn Protein, Human, Recombinant (GST)

Cat.No: TMPY-04391

Species: Human

Expression System: Baculovirus Insect Cells

STAT1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02240

Species: Human

Expression System: Baculovirus Insect Cells

MAPK3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01692

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T11640	Imatinib-d8 CGP-57148B D8,STI571 D8	Others	Others
	Imatinib D8 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.
TMIH-0378	N-desmethyl Imatinib-d4
	N-desmethyl Imatinib-d4 是 N-desmethyl Imatinib 的氘代化合物。N-desmethyl Imatinib 的 CAS 号为 404844-02-6。N-Desmethyl imatinib 是 Imatinib 的代谢物。Imatinib 是一个靶向 c-Kit、v-Abl和 PDGFR 的多靶点抑制剂。
TMIJ-0124	Regorafenib-13C-d3
	Regorafenib-13C-d3 是 Regorafenib 的 13C 和氘代化合物。Regorafenib 的 CAS 号为 755037-03-7。Regorafenib 是一种多靶点受体酪氨酸激酶抑制剂，对 RET、C-RAF、VEGFR2、c-Kit、VEGFR1和PDGFRβ 的 IC50为1.5、2.5、4.2、7、13和22 nM。
T11639	Imatinib D4 CGP-57148B D4,STI571 D4	Others	Others
	Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.
TMID-0288	Apatinib-d8
	Apatinib-d8 是 Apatinib 的氘代化合物。Apatinib 的 CAS 号为 811803-05-1。Apatinib 是一种口服生物可利用的特异性 VEGFR2 抑制剂 (IC50: 1 nM)。此外，该试剂温和地抑制 c-Kit 和 c-SRC 酪氨酸激酶。
TMIJ-0125	Regorafenib-13C-d3 N-Oxide
	Regorafenib-13C-d3 N-Oxide 是 Regorafenib N-Oxide 的 13C 和氘代化合物。Regorafenib N-Oxide 的 CAS 号为 835621-11-9。Regorafénib N-oxyde M2 是 Regorafenib 的活性代谢物。Regorafenib 是多靶点抑制剂，包括VEGFR1/2/3，PDGFRβ，Kit，RET 和 Raf-1 ， IC50分别是 13/4.2/46，22，7，1.5 和 2.5 nM。
TMIJ-0154	Lenvatinib-d4
	Lenvatinib-d4 是 Lenvatinib 的氘代化合物。Lenvatinib 的 CAS 号为 417716-92-8。Lenvatinib 是一种口服具有活性的，多靶点酪氨酸激酶抑制剂，能够抑制血管内皮生长因子受体(VEGFR1-3)，成纤维细胞生长因子受体(FGFR1-4)，干细胞因子受体(KIT)，血小板衍生生长因子受体(PDGFR)，转染期间重排(RET)，具有效抗癌的作用。
T12521	Ponatinib-d8 AP24534 D8	Others	Others
	Ponatinib D8 is a deuterium labeled Ponatinib. Ponatinib is an orally active inhibitor of multi-targeted kinase(Abl, PDGFRα, VEGFR2, FGFR1, and Src with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM, respectively).

同位素标记化合物

Cat.No: T11640

Synonym: CGP-57148B D8,STI571 D8

Target: Others

N-desmethyl Imatinib-d4

Cat.No: TMIH-0378

Regorafenib-13C-d3

Cat.No: TMIJ-0124

Cat.No: T11639

Synonym: CGP-57148B D4,STI571 D4

Target: Others

Cat.No: TMID-0288

Regorafenib-13C-d3 N-Oxide

Cat.No: TMIJ-0125

Cat.No: TMIJ-0154

Cat.No: T12521

Synonym: AP24534 D8

Target: Others

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