226
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Cat. No. | Product Name | ||
---|---|---|---|
L7840 | 高溶解性卤化片段化合物库 | 796 compounds | |
高溶解性卤化片段库包含796 个卤化片段化合物。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22089 |
HPI 1
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
HPI 1 是一种刺猬 (Hh) 信号抑制剂。在 Shh-LIGHT2 细胞中抑制 Sonic Hedgehog (Shh)-、SAG- 和 Gli 诱导的 Hh 通路激活(Shh-、SAG-、Gli2- 和 Gli1 诱导的激活的 IC50 值为 1.5、1.5、4 和 6 μM) . | |||
T24159 |
IHR-1
IHR 1 |
Smo | Stem Cells |
IHR-1 是一种Smo 拮抗剂,不能透过细胞膜。 | |||
T15370 |
GANT 58
4,44乔,4乔(2,3,4,5-Thiophentetrayl)tetrakis-pyridine,NSC 75503 |
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
GANT 58 (NSC-75503) 是GLI 拮抗剂,能够抑制 GLI1 诱导的转录,其IC50=5 μM。 | |||
T3070 |
GANT 61
NSC 136476,GANT61 |
Hedgehog/Smoothened; Autophagy | Autophagy; GPCR/G Protein; Stem Cells |
GANT 61 (GANT61) 是一种Gli1和Gli2抑制剂,靶向Hedgehog/GLi 通路。 | |||
T6203 |
Saxagliptin
BMS-477118,沙克列汀,Onglyza,沙格列汀 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Saxagliptin (BMS-477118) 是一种选择性,可逆性,竞争性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin 能够用于 2 型糖尿病的研究。 | |||
T12710 |
Retagliptin Phosphate
SP 2086,瑞格列汀磷酸盐 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Retagliptin Phosphate (SP 2086) 是一种选择性、竞争性、口服活性的二肽基肽酶 4 (DPP-4) 抑制剂。Retagliptin phosphate 能够用于 2 型糖尿病 (T2DM) 的研究。 | |||
T64332 |
Glimepiride sulfonamide
|
Immunology/Inflammation related | Immunology/Inflammation |
Glimepiride sulfonamide 是一种抗炎活性化合物。 | |||
T28757 |
Sergliflozin etabonate
GW-869682,GW-869682X,KGT-1251,GW869682X,GW869682,KGT1251 |
SGLT | GPCR/G Protein |
Sergliflozin etabonate (KGT-1251) 是一种 SGLT-2 抑制剂,可用于 2 型糖尿病和肥胖症的研究。 | |||
T34286 |
Remogliflozin etabonate
GSK189075,GSK 189075,GSK-189075A,GSK189075A,GSK-189075,GSK 189075A |
SGLT | GPCR/G Protein |
Remogliflozin etabonate (GSK189075A) 是 regaliflozin 的前药和 SGLT2 抑制剂,对 hSGLT2、rSGLT2、rSGLT1 和 hSGLT1 的 Ki 值分别为 1.95、2.14、8.57 和 43.1μM。 | |||
T2385 |
Ipragliflozin
伊格列净,ASP1941 |
SGLT | GPCR/G Protein |
Ipragliflozin (ASP1941) 是一种口服有效的,选择性的 SGLT2抑制剂,对人 SGLT2 和 SGLT1,大鼠 SGLT2 和 SGLT1,小鼠 SGLT2 和 SGLT1 的 IC50分别为 7.38 和 1876 nM,6.73 和 1166 nM,5.64 和 1380 nM。Ipragliflozin 具有抗糖尿病活性。 | |||
T0191 |
Linagliptin
BI 1356,利格列汀,利拉利汀 |
Ferroptosis; Proteasome; DPP-4; Autophagy | Apoptosis; Autophagy; Proteases/Proteasome; Ubiquitination |
Linagliptin (BI 1356) 是一种有效的、可口服的、基于二氢嘌呤二酮的二肽基肽酶 4 抑制剂,具有降血糖活性。 | |||
T1502 |
Vildagliptin
维达列汀,NVP-LAF 237,维格列汀,LAF237 |
Apoptosis; Ferroptosis; Proteasome; DPP-4 | Apoptosis; Proteases/Proteasome; Ubiquitination |
Vildagliptin (LAF237) 是一种选择性二肽基肽酶IV (DPP-IV) 抑制剂,在人 Caco-2 细胞中抑制 DPP-IV 的IC50为 3.5 nM。它具有出色的口服生物利用度和降血糖活性。 | |||
T0242L |
Sitagliptin phosphate monohydrate
MK-0431,MK-0431 phosphate monohydrate,西他列汀磷酸盐一水合物 |
Proteasome; DPP-4; Autophagy | Autophagy; Proteases/Proteasome; Ubiquitination |
Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) 是一种有效的 DPP-IV 抑制剂,在 Caco-2 细胞提取物中的 IC50 为 19 nM。 | |||
T12835 |
Saroglitazar
Lipaglyn |
PPAR | DNA Damage/DNA Repair; Metabolism |
Saroglitazar (Lipaglyn) 是 PPAR 的激动剂,对 PPARα 和 PPARγ 的 EC50 值为 0.65 pM 和 3 nM。 | |||
T10998 |
Deriglidole
SL 86-0715 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Deriglidole (SL 86-0715) 是一种外周肾上腺素能受体拮抗剂,是一种具有选择性的α2受体抑制剂。 Deriglidole 对可乐定和 Idazoxan 有抑制作用而对哌唑嗪与大鼠皮质和人血小板α2-肾上腺素能受体不显示活性。 | |||
T1634 |
Glibenclamide
格列本脲,Glyburide |
Potassium Channel; Mitochondrial Metabolism; CFTR; P-gp; Autophagy | Autophagy; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Glibenclamide (Glyburide) 是一种具有口服活性的 ATP 敏感的 K+通道抑制剂,可研究糖尿病和肥胖。它抑制 P-糖蛋白,可直接结合并阻断 KATP 的 SUR1亚基并抑制囊性纤维化跨膜传导调节蛋白。它通过诱导膜离子通透性干扰线粒体生物能,可诱导自噬。 | |||
T19710 |
Ciglitazone
Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878 |
Apoptosis; p38 MAPK; PPAR | Apoptosis; DNA Damage/DNA Repair; MAPK; Metabolism |
Ciglitazone (ADD 3878) 是一种强效和选择性的PPARγ激动剂(EC50:3μM)和口服降糖药。Ciglitazone 抑制th17细胞的增殖和分化,降低胰岛素水平、血管内皮生长因子的产生和血压,诱导胃癌细胞的细胞周期停止。Ciglitazone 能诱导负鼠肾上皮细胞的凋亡,激活p38 MAPK 和凋亡诱导因子(AIF)的核转位。 Ciglitazone 在肥胖症和高血糖症的动物模型中表现出降血糖活性。 | |||
T4639 |
Azemiglitazone
MSDC 0602 |
Mitochondrial Metabolism; mTOR | Metabolism; PI3K/Akt/mTOR signaling |
Azemiglitazone (MSDC 0602) 是一种 PPARγ 保留的噻唑烷二酮类药物 (TZD),与能够线粒体丙酮酸载体 (MPC) 相互作用并抑制其活性,降低 pparγ 介导的副作用的风险,有用于 2 型糖尿病研究的潜能。 | |||
T0214 |
Pioglitazone
U 72107,吡格列酮,匹格列酮 |
Ferroptosis; PPAR | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Pioglitazone (U 72107) 是一种胰岛素增敏剂和噻唑烷二酮,适用于治疗 2 型糖尿病。它是一种选择性PPARγ激动剂,高亲和力结合到 PPARγ 配体结合域,作用于人和鼠 PPARγ的EC50分别为 0.93 和 0.99 μM。 | |||
T3104 |
Globalagliatin
LY2608204 |
Glucokinase | Metabolism |
Globalagliatin (LY2608204) 是一种葡萄糖激酶 (GK) 活化剂,EC50=42 nM。 | |||
T26986 |
Cevoglitazar
LBM-642,LBM 642,LBM642 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Cevoglitazar (LBM-642) 是一种 PPARɑ 激动剂和 PPARγ激动剂。Cevoglitazar 能有效减少肥胖小鼠和猴的食物摄入量和体重。 | |||
T16009L |
Managlinat dialanetil
MB06322,MB 6322,CS-917 |
Phosphatase | Metabolism |
Managlinat dialanetil (MB06322) 是一种可口服且具有有效性的 fructose 1,6-bisphosphatase (FBPase) 抑制剂,具有降糖活性,可用于研究 2 型糖尿病。 | |||
T6237 |
Trelagliptin
SYR-472,曲格列汀 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Trelagliptin (SYR-472) 是一种有效的,具有口服活性的DPP-4抑制剂,IC50=4 nM。它可以改善体内血糖控制,能够用于2 型糖尿病 (T2DM) 的研究。 | |||
T22708 |
Darglitazone
CP-86325 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Darglitazone (CP-86325) 是一种噻唑烷二酮,是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢,在 II 型糖尿病中有研究价值。 | |||
T1622 |
Rosiglitazone maleate
BRL 49653C,BRL 49653,马来酸罗格列酮 |
Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Rosiglitazone maleate (BRL 49653) 是一种选择性PPARγ激活剂,具有抗糖尿病特性和潜在抗肿瘤活性。它也是TRP 通道调节剂,可抑制 TRPM2、TRPM3 的活性,激活 TRPC5。 | |||
T15575 |
Indeglitazar
PPM 204 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Indeglitazar (PPM 204) 是 PPAR 的泛激动剂,包括亚型 alpha (α)、delta (δ) 和 gamma (γ)。 | |||
T28501 |
Ragaglitazar
NNC61-0029,NN-622,(-)-DRF-2725,NNC-61-0029,NN 622,NNC 61-0029 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Ragaglitazar(NNC-61-0029) 是一种有效的 PPARα和 PPARγ双重激动剂,在动物模型中显示出有效的降脂和胰岛素增敏作用。Ragaglitazar 可用于研究 2 型糖尿病。 | |||
T16083 |
Mizagliflozin
GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base |
SGLT | GPCR/G Protein |
Mizagliflozin (GSK-1614235 free base) 是口服有效的、选择性的 SGLT1抑制剂,对人 SGLT1 的 Ki 值为 27 nM。Mizagliflozin 对 SGLT1 的选择性是 SGLT2的303 倍。它是抗糖尿病药物,可以改善餐后血糖波动。它在改善慢性便秘方面具有潜在的作用。 | |||
T7486 |
Imeglimin hydrochloride
EMD 387008 hydrochloride,(6R)-1,6-二氢-N2,N2,6-三甲基-1,3,5-三嗪-2,4-二胺盐酸盐 |
Reactive Oxygen Species; Mitochondrial Metabolism | Immunology/Inflammation; Metabolism; NF-κB |
Imeglimin hydrochloride (EMD 387008 hydrochloride) 是一种口服降糖剂。Imeglimin 可改善胰岛素敏感性,能够抑制活性氧的产生、增加线粒体 DNA、改善线粒体功能。 | |||
T1674 |
Nateglinide
那格列奈,A4166,Senaglinide |
Potassium Channel; Proteasome; PPAR | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome; Ubiquitination |
Nateglinide (Senaglinide) 是 D-苯丙氨酸的一种衍生物,是口服有效的、短效促胰岛素释放化合物,也是 DPP IV 抑制剂。 Nateglinide 抑制胰岛 β 细胞中 ATP 敏感的 K+通道。Nateglinide 在 2 型糖尿病中具有研究价值。 | |||
T7133 |
Anagliptin
SK-0403,阿拉格列汀 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Anagliptin (SK-0403) 是一种选择性的二肽酰肽酶 4 抑制剂,IC50=3.8 nM,对 DPP-8/9 的选择性相对较弱,IC50分别为 68 和 60 nM。 | |||
T0334 |
Rosiglitazone
BRL49653,罗格列酮 |
Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Rosiglitazone (BRL49653) 是一种 PPARγ 激动剂、TRPC5 激活剂和 TRPM3 抑制剂,具有口服活性。Rosiglitazone 也是一种降糖剂,是噻唑烷二酮类胰岛素增敏剂。 | |||
T0178 |
Saxagliptin hydrate
沙格列汀单水化合物,Onglyza hydrate,BMS-477118 hydrate |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Saxagliptin hydrate (Onglyza hydrate) 是一种选择性,竞争性,可逆性和口服活性的二肽基肽酶 4 (DPP-4) (Ki= 0.6-1.3 nM) 抑制剂。Saxagliptin hydrate 能够用于 2 型糖尿病的研究。 | |||
T4460 |
Dapagliflozin ((2S)-1,2-propanediol, hydrate)
BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate |
SGLT | GPCR/G Protein |
Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) 是 Dapagliflozin 1,2-propanediol, hydrate 的 S 型异构体,是竞争性葡萄糖协同转运蛋白2 抑制剂,可促进尿液中葡萄糖的排泄,可用于糖尿病的研究。它诱导 HIF1表达并减轻肾脏 IR 损伤。 | |||
T28743 |
Seglitide acetate
MK 678,MK678,MK-678 |
Somatostatin | GPCR/G Protein |
Seglitide acetate (MK-678) 是一种选择性的 sst2生长抑素受体激动剂。 | |||
T23358 |
Sitagliptin phosphate
磷酸西他列汀,Januvia,MK-0431 phosphate,Sitagliptin (phosphate) |
DPP-4; Autophagy | Autophagy; Proteases/Proteasome |
Sitagliptin phosphate (MK-0431 phosphate) 是一种二肽基肽酶 4 (DPP4) 抑制剂,在 Caco-2 细胞中,IC50值为 19 nM。 | |||
T2401 |
Alogliptin Benzoate
苯甲酸阿格列汀,SYR 322,Alogliptin(SYR-322)benzoate |
Ferroptosis; Proteasome; DPP-4 | Apoptosis; Proteases/Proteasome; Ubiquitination |
Alogliptin Benzoate (SYR 322) 是一种有效且特异性的 DPP-4 抑制剂 ,IC50值小于 10 nM,其选择性比 DPP-8/9 高 10,000 倍以上,可用于研究 2 型糖尿病。 | |||
T27841 |
Lobeglitazone Sulfate
CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang |
NOD | Immunology/Inflammation; NF-κB |
Lobeglitazone Sulfate(CKD-501 Sulfate) 是一种新型噻唑烷二酮,具有抗炎活性,抑制LPS诱导的NLRP3炎症小体活化和肝脏炎症,可用于研究 2 型糖尿病 (T2DM)。 | |||
T14176 |
Aleglitazar
RO0728804,R1439 |
PPAR | DNA Damage/DNA Repair; Metabolism |
Aleglitazar (R1439) 是一种高效的 PPARα/γ 双重激动剂,对人 PPARα 和 PPARγ 作用的 IC50 分别为 38 nM 和 19 nM。Aleglitazar 可用于 II 型糖尿病的研究。 | |||
T1875 |
Atglistatin
|
Lipase | Metabolism |
Atglistatin 是脂肪甘油三酯脂酶的选择性抑制剂(IC50:0.7 μM),在体外具有抑制脂解的功能。 | |||
T68053 |
Denagliptin
GW823093 |
DPP-4 | Proteases/Proteasome |
Denagliptin是一种小分子二肽基肽酶IV(DPP-4)抑制剂,可用于治疗内分泌于代谢疾病,可用于研究2型糖尿病。 | |||
T17044 |
Tesaglitazar
|
PPAR | DNA Damage/DNA Repair; Metabolism |
Tesaglitazar 是一种有效且具有选择性的过氧化物 PPAR α / γ受体双重激动剂,对 PPARγ的亲和力比 PPARα更有效,对大鼠PPARα和人PPARα的EC50分别为13.4 μM 和3.6 μM,对大鼠PPARγ和人类 PPARγ的EC50都是0.2 μM。Tesaglitazar 诱导大鼠皮下组织间质间充质细胞DNA 合成和纤维肉瘤形成。 | |||
T2389 |
Dapagliflozin
达格列净,BMS-512148 |
SGLT; HIF | Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein |
Dapagliflozin (BMS-512148) 是一种葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可与靶点竞争性结合。Dapagliflozin 可用于 2 型糖尿病的治疗,可以减少肾脏的葡萄糖重吸收,增加尿液中葡萄糖的排泄,从而降低血浆葡萄糖水平。 | |||
T22860 |
Imeglimin
EMD 387008,EMD-387008,RVT-1501,PXL 008 |
ROS; Mitochondrial Metabolism | Immunology/Inflammation; Metabolism |
Imeglimin (EMD 387008) 是一种可口服的抗糖尿病化合物,可增强线粒体功能、增强胰岛素分泌、促进β细胞增殖并改善小鼠胰岛β细胞存活率。 | |||
T1782 |
Canagliflozin
卡格列净,JNJ 24831754ZAE,JNJ 28431754AAA,TA 7284,JNJ 28431754 |
SGLT | GPCR/G Protein |
Canagliflozin (JNJ 28431754AAA) 是SGLT2的选择性抑制剂,在表达 mSGLT2,rSGLT2 和 hSGLT2 的 CHO 细胞上,IC50分别为 2 nM,3.7 nM 和 4.4 nM。 | |||
T0127 |
Glimepiride
Glimperide,HOE-490,格列美脲 |
Potassium Channel | Membrane transporter/Ion channel |
Glimepiride (HOE-490) 是一种中长效的磺酰脲类抗糖尿病化合物,其 ED50=182 μg/k。 | |||
T7217 |
Bexagliflozin
THR-1442,EGT1442,EGT0001442 |
SGLT | GPCR/G Protein |
Bexagliflozin (EGT1442) 是一种选择性的,口服有效的钠葡萄糖协同转运蛋白-2 (SGLT2) 抑制剂,对人 SGLT2 和 SGLT1 作用的 IC50值分别为 2 nM 和 5.6 μM。EGT1442在 2 型糖尿病中有研究价值。 | |||
T7369L |
Gemigliptin Tartrate(911637-19-9 free base)
吉格列汀酒石酸盐,LC15-0444 tartrate |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Gemigliptin Tartrate (LC15-0444 tartrate) 是一种选择性的,可逆的,竞争性的二肽基肽酶 4 (DPP-4) 抑制剂,对于人重组 DPP-4 的IC50=10.3 nM。Gemigliptin tartrate 具有很强的抗糖基化活性,能够用于晚期糖基化终产物相关的糖尿病并发症的研究。 | |||
T6999 |
Teneligliptin hydrobromide
Teneligliptin hydrobromide anhydrous,MP-513 (hydrobromide) |
Others; Proteasome; DPP-4 | Others; Proteases/Proteasome; Ubiquitination |
Teneligliptin hydrobromide (MP-513(hydrobromide)) 是β2肾上腺素能受体 (β2AR) 阻滞剂,具有抗高血压、抗氧化、清除自由基的活性。 | |||
T7369 |
Gemigliptin
吉格列汀酒石酸盐,LC15-0444 |
Proteasome; DPP-4 | Proteases/Proteasome; Ubiquitination |
Gemigliptin (LC15-0444) 是一种选择性的,可逆的,竞争性的二肽基肽酶 4 (DPP-4) 抑制剂,对人重组 DPP-4 的 IC50=10.3 nM。Gemigliptin 具有很强的抗糖基化活性,能够用于晚期糖基化终产物相关的糖尿病并发症的研究。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6723 |
Voglibose
AO 128,伏格列波糖,Glustat,Basen |
Glucosidase | Metabolism |
Voglibose (Glustat) 是一种 valiolamine 的衍生物,可抑制α-葡萄糖苷酶活性,可作用于高血糖症等。 | |||
T5542 |
Tiglic acid
惕格酸,Sabadillic acid,Tiglinic acid,巴豆酸,Cevadic acid |
Endogenous Metabolite; HSV | Metabolism; Microbiology/Virology |
Tiglic acid 是一种存在于巴豆油和其他几种天然产物中的单羧酸不饱和有机酸。它具有植物代谢物的作用。 | |||
T1529 |
Miglitol
BAY1099,米格列醇,BAY-m1099 |
Others | Others |
Miglitol (BAY1099) 是一种口服抗糖尿病化合物,能够抑制糖复合体分解为葡萄糖。 | |||
TN3520 |
Bisdethiobis(methylthio)gliotoxin
|
PAFR | GPCR/G Protein |
Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist. | |||
TN6086 |
Machigline
|
||
Machigline 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6086,CAS号为 87264-30-0。 | |||
TN4137 |
Glicoricone
|
MAO | Metabolism; Neuroscience |
Glicoricone acts as a partial estrogen antagonist. Glicoricone inhibited the monoamine oxidase with the IC50 values of 6.0 x 10(-5)-1.4 x 10(-4) M. | |||
TN3362 |
Aglinin A
|
Others | Others |
Aglinin A displays moderate cytotoxicity against all the three cancer cell lines((NCI-H187), epidermoid carcinoma (KB) and breast cancer (BC) cell lines). | |||
T41304 |
Hydroaurantiogliocladin
|
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Hydroaurantiogliocladin 在生命科学相关研究中具有广泛的应用。 | |||
T82341 |
Ganglioside GM1
|
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Ganglioside GM1,一种神经节苷脂家族成员,用于神经系统疾病研究。同时,它作为霍乱毒素 1 的功能性组织受体。 | |||
T35741 |
Gliovirin
|
Others | Others |
Gliovirin is a fungal metabolite that has been found inT. harzianumand has fungicidal, antimicrobial and anti-inflammatory activities.1It is active against the plant pathogenic fungusP. ultimum(MIC = 60 ng/ml) and the parasiteT. brucei brucei(IC50= 90 ng/ml), but has no effect on the plant pathogenic fungiR. solani,P. omnivorum,T. basicola,R. arrhizus, andV. dahliaeor the bacteriaB. thuringiensis,P. fluorescens, andX. malvacearumwhen used at concentrations up to 1,000 ng/ml.2,3Gliovirin decrease... | |||
T31935 |
Gliorosein
|
Others | Others |
Gliorosein is a biohcemical. | |||
TN5409 |
Maglifloenone
Denudatone |
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Maglifloenone是一种天然产物,属于木兰科木兰属,其产品编号为 TN5409,CAS号为 82427-77-8。Maglifloenone可用作对照参考。 | |||
T74200 |
Glicophenone
|
Others | Others |
Glicophenone 作为一种抗细菌(antibacterial)剂,对MRSA OM481、MRSA OM505、MRSA OM584、MRSA OM623 以及MSSA 209P的MIC值均为32 μg/mL。 | |||
T82277 |
GM1a Ganglioside oligosaccharide
|
||
GM1a Ganglioside oligosaccharide为ganglioside GM1的半合成形式,后者作为霍乱毒素的天然受体,在生长调节及激素诱导反应的耦合中具有关键功能。 | |||
T82339 |
Gangliotetraose
Gg4 |
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Gangliotetraose(Gg4)是一种含有GM1及其唾液酸化衍生物的四糖。它能促进分化神经元核内Ca2+的外流,进而降低核内Ca2+浓度。Gg4参与调节神经元的可塑性、修复过程以及大脑中神经营养素的释放。 | |||
TN1694 |
Gliotoxin
|
Apoptosis; NF-κB; Wnt/beta-catenin; COX; PKA; Antibacterial; Antifection | Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors |
Gliotoxin 是一种次生代谢产物,由A. fumigatus 分泌,可以抑制巨噬细胞的吞噬作用和其他免疫细胞的免疫功能。它通过阻止 IκB 降解来抑制诱导型NF-κB 活性,从而诱导宿主细胞凋亡。它可以激活PKA 并增加细胞内 cAMP 浓度,调节肌动蛋白细胞骨架重排以促进A. fumigatus 内化到肺上皮细胞。 | |||
TN1379 |
Alphitolic acid
麦珠子酸 |
NF-κB; Akt; p53 | Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling |
Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotoxicity against cancer cells. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02321 |
GLI1 Protein, Human, Recombinant (His)
Zinc finger protein GLI1,Glioma-associated... |
Human | E. coli |
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling.; Acts as a transcriptional activator, but activates a different set of genes tha... | |||
TMPY-01457 |
GLIPR1 Protein, Human, Recombinant (His)
RTVP1,GLI pathogenesis-related 1,CRISP7,GLI |
Human | HEK293 Cells |
GLIPR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.7 kDa and the accession number is P48060-1. | |||
TMPY-03940 |
GLIPR1 Protein, Mouse, Recombinant (His)
RTVP-1,2410114O14Rik,mRTVP-1,GLI pathogenesis-relat... |
Mouse | HEK293 Cells |
GLIPR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.1 kDa and the accession number is Q4QQK5. | |||
TMPY-01384 |
Endoglin/CD105 Protein, Human, Recombinant (His)
endoglin,HHT1,END,ORW1 |
Human | HEK293 Cells |
Endoglin/CD105 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.3 kDa and the accession number is A0A024R878. | |||
TMPY-00783 |
Endoglin/CD105 Protein, Human, Recombinant (hFc)
END,HHT1,ORW1,endoglin |
Human | HEK293 Cells |
Endoglin/CD105 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 87.5 kDa and the accession number is A0A024R878. | |||
TMPH-03646 |
Omega-gliadin Protein, Triticum monococcum, Recombinant (E. coli, GST)
Omega-gliadin |
Triticum monococcum | E. coli |
N/A. Omega-gliadin Protein, Triticum monococcum, Recombinant (E. coli, GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 30.3 kDa and the accession number is P02865. | |||
TMPY-04227 |
Gliomedin Protein, Human, Recombinant (hFc)
COLM,CRGL2,UNC-112,gliomedin,CRG-L2,CLOM |
Human | HEK293 Cells |
Gliomedin Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 74.3 kDa and the accession number is AAQ88511.1. | |||
TMPY-06725 |
Jug r 1 Protein, English walnut, Recombinant
|
English walnut | E. coli |
Jug r 1 Protein, English walnut, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.3 kDa. | |||
TMPY-01615 |
Endoglin/CD105 Protein, Mouse, Recombinant (His)
Endo,CD105,S-endoglin,AI528660,endoglin,AI... |
Mouse | HEK293 Cells |
Endoglin/CD105 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 61.2 kDa and the accession number is Q63961. | |||
TMPH-03647 |
Omega-gliadin Protein, Triticum monococcum, Recombinant (GST)
Omega-gliadin |
Triticum monococcum | P. pastoris (Yeast) |
N/A. Omega-gliadin Protein, Triticum monococcum, Recombinant (GST) is expressed in yeast with N-GST tag. The predicted molecular weight is 30.3 kDa and the accession number is P02865. | |||
TMPK-00359 |
Endoglin/CD105 Protein, Human, Recombinant (His & Avi)
CD105,ORW,ORW1,ENG,END,Endoglin,HHT1 |
Human | HEK293 Cells |
Endoglin (CD105) is a 90 kDa type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin is a vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (PubMed:7894484). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response... | |||
TMPJ-00361 |
Endoglin Protein, Human, Recombinant (Trx & His)
CD105,END,Endoglin,ENG |
Human | E. coli |
Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and/or TGFBR2. It may have an important role in the binding of endothelial cells to integrins an... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIH-0517 |
Saroglitazar oxide-d4
|
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Saroglitazar oxide-d4 是 Saroglitazar oxide 的氘代化合物。Saroglitazar oxide 的 CAS 号为 495399-09-2。Saroglitazar 是 PPAR 的激动剂,对 PPARα 和 PPARγ 的 EC50 值为 0.65 pM 和 3 nM。 | |||
TMIH-0253 |
Gliclazide-d7
|
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Gliclazide-d7 是 Gliclazide 的氘代化合物。Gliclazide 的 CAS 号为 21187-98-4。Gliclazide 是一种有效的全细胞的 β 细胞 ATP 敏感型钾流阻断剂,IC50为 184 nM,用作降糖药。 | |||
TMIH-0516 |
Saroglitazar-d4
|
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Saroglitazar-d4 是 Saroglitazar 的氘代化合物。Saroglitazar 的 CAS 号为 495399-09-2。Saroglitazar 是 PPAR 的激动剂,对 PPARα 和 PPARγ 的 EC50 值为 0.65 pM 和 3 nM。 | |||
T10669 |
Canagliflozin-d4
Canagliflozin D4 |
Others | Others |
Canagliflozin D4 is a deuterium-labeled Canagliflozin. Canagliflozin is an SGLT2 inhibitor. | |||
TMIJ-0142 |
Vildagliptin-d7
|
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Vildagliptin-d7 是 Vildagliptin 的氘代化合物。Vildagliptin 的 CAS 号为 274901-16-5。Vildagliptin 是一种选择性二肽基肽酶IV (DPP-IV) 抑制剂,在人 Caco-2 细胞中抑制 DPP-IV 的IC50为 3.5 nM。它具有出色的口服生物利用度和降血糖活性。 | |||
TMIJ-0126 |
5-Hydroxy Saxagliptin-13C-d2 HCl
|
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5-Hydroxy Saxagliptin-13C-d2 HCl 是 5-Hydroxy Saxagliptin HCl 的 13C 和氘代化合物。5-Hydroxy Saxagliptin HCl 的 CAS 号为 841302-24-7。 | |||
T19548 |
Repaglinide D5
AG-EE 623ZW D5,瑞格列奈 D5 |
Others | Others |
Repaglinide D5 is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for treatment type-2 diabetes mellitus. | |||
TMIH-0302 |
Linagliptin-d4
|
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Linagliptin-d4 是 Linagliptin 的氘代化合物。Linagliptin 的 CAS 号为 668270-12-0。Linagliptin 是一种有效的、可口服的、基于二氢嘌呤二酮的二肽基肽酶 4 抑制剂,具有降血糖活性。 | |||
TMIH-0013 |
(S)-Empagliflozin-d4
|
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(S)-Empagliflozin-d4 是 (S)-Empagliflozin 的氘代化合物。(S)-Empagliflozin 的 CAS 号为 864070-44-0。Empagliflozin 是有效的、选择性的钠葡萄糖协同转运蛋白-2 (SGLT-2) 抑制剂,对人 SGLT-2 的IC50为 3.1 nM。 | |||
TMIJ-0153 |
Dapagliflozin-13C6 (glucitol-13C6)
|
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Dapagliflozin-13C6 (glucitol-13C6) 是 Dapagliflozin 的 13C 的标记化合物。Dapagliflozin 的 CAS 号为 461432-26-8。Dapagliflozin竞争性的葡萄糖协同转运蛋白2 (SGLT2) 抑制剂,可促进尿液中葡萄糖的排泄,在糖尿病 (DM) 研究中具有价值。Dapagliflozin 诱导HIF1表达并减轻肾脏 IR 损伤。 | |||
T10288 |
Alogliptin (13CD3)
SYR-322 (13CD3) |
Others | Others |
Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4. | |||
TMIH-0010 |
(S)-Alogliptin Benzoate Salt-13C-d3
|
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(S)-Alogliptin Benzoate Salt-13C-d3 是 (S)-Alogliptin Benzoate Salt 的 13C 和氘代化合物。 | |||
TMIH-0045 |
3-Hydroxy Repaglinide-d5
|
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3-Hydroxy Repaglinide-d5 是 3-Hydroxy Repaglinide 的氘代化合物。 | |||
TMIJ-0133 |
Empagliflozin-d4
|
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Empagliflozin-d4 是 Empagliflozin 的氘代化合物。Empagliflozin 的 CAS 号为 864070-44-0。Empagliflozin 是有效的、选择性的钠葡萄糖协同转运蛋白-2 (SGLT-2) 抑制剂,对人 SGLT-2 的IC50为 3.1 nM。 | |||
TMIJ-0156 |
rac-Sitagliptin-d4 HCl
|
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rac-Sitagliptin-d4 HCl 是 rac-Sitagliptin HCl 的氘代化合物。 | |||
TMIJ-0143 |
Linagliptin-13C-d3
|
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Linagliptin-13C-d3 是 Linagliptin 的 13C 和氘代化合物。Linagliptin 的 CAS 号为 668270-12-0。Linagliptin 是一种有效的、可口服的、基于二氢嘌呤二酮的二肽基肽酶 4 抑制剂,具有降血糖活性。 | |||
T71981 |
Gliclazide-d4
|
||
Gliclazide-d4 is intended for use as an internal standard for the quantification of gliclazide by GC- or LC-MS. Gliclazide is a sulfonylurea and an inhibitor of pancreatic β-cell ATP-sensitive potassium (KATP) channels. It is selective for pancreatic β-cell over cardiac and arterial smooth muscle cell KATP channels. Gliclazide (5 μM) increases insulin-induced glucose uptake and glucose transporter 4 (GLUT4) translocation to the plasma membrane in a differentiated 3T3L1 adipocyte model of insulin... | |||
TMIH-0267 |
Hydroxy Pioglitazone M-IV-d4
|
||
Hydroxy Pioglitazone M-IV-d4 是 Hydroxy Pioglitazone M-IV 的氘代化合物。 | |||
T12178 |
Nateglinide D5
Senaglinide D5,A4166 D5 |
Others | Others |
Nateglinide D5 is a deuterium labeled Nateglinide. | |||
T12479 |
Pioglitazone-d4
U 72107 D4 |
Others | Others |
Pioglitazone D4 is a deuterium labeled Pioglitazone. Pioglitazone is a agonist of PPARγ . | |||
TMIH-0583 |
Trelagliptin-13C-d3
|
||
Trelagliptin-13C-d3 是 Trelagliptin 的 13C 和氘代化合物。Trelagliptin 的 CAS 号为 865759-25-7。Trelagliptin 是一种有效的,具有口服活性的DPP-4抑制剂,IC50=4 nM。它可以改善体内血糖控制,能够用于2 型糖尿病 (T2DM) 的研究。 | |||
T10958 |
Dapagliflozin-d5
BMS-512148 D5 |
Others | Others |
Dapagliflozin D5 (BMS-512148 D5) is deuterated Dapagliflozin. Dapagliflozin is a competitive SGLT2 inhibitor. | |||
T13121 |
Teneligliptin D8
MP-513 D8 |
Others | Others |
Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4. | |||
TMIJ-0093 |
Keto Pioglitazone-d4
|
||
Keto Pioglitazone-d4 是 Keto Pioglitazone 的氘代化合物。Keto Pioglitazone 的 CAS 号为 146062-45-5。 | |||
TMID-0267 |
Glipizide-d11
|
||
Glipizide-d11 是 Glipizide 的氘代化合物。Glipizide 的 CAS 号为 29094-61-9。Glipizide 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent),在 2 型糖尿病的研究中具有价值,但不适用于1 型糖尿病。Glipizide 是通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP)发挥活性 。 | |||
TMIJ-0523 |
Gliquidone-d6
|
||
Gliquidone-d6 是 Gliquidone 的氘代化合物。Gliquidone 的 CAS 号为 33342-05-1。Gliquidone 是一种磺酰脲类的抗糖尿病药物,可用于2型糖尿病的研究。 |