Atglistatin

Atglistatin 是脂肪甘油三酯脂酶的选择性抑制剂(IC50:0.7 μM)，在体外具有抑制脂解的功能。

产品编号 T1875Cas号 1469924-27-3

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Atglistatin

产品编号 T1875Cas号 1469924-27-3

Atglistatin 是脂肪甘油三酯脂酶的选择性抑制剂(IC50:0.7 μM)，在体外具有抑制脂解的功能。

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规格	价格	库存
1 mg	¥ 265	现货
2 mg	¥ 372	现货
5 mg	¥ 663	现货
10 mg	¥ 995	现货
25 mg	¥ 1,870	现货
50 mg	¥ 3,280	现货
100 mg	¥ 4,780	现货
500 mg	¥ 9,870	现货
1 mL x 10 mM (in DMSO)	¥ 713	现货

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"Atglistatin"的相关化合物库

产品介绍

生物活性

产品描述	Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the concentration up to 50 μM.
靶点活性	ATGL:0.7 μM
体外活性	Atglistatin可抑制ATGL,从而使细胞和器官培养中的脂类分解受到抑制,且浓度达50 μM时仍无细胞毒性。
体内活性	Atglistatin（p.o.）剂量依赖性地减少FA和甘油,减少量分别高达50%和62%,也会显著减少血浆中TG水平（43%）.在体内,Atglistatin(i.p.)剂量与时间依赖性地抑制脂类分解.此外,Atglistatin有明显的组织分布差异,主要在肝脏和脂肪组织中积累。
激酶实验	Determination of lipase activity: For determination of lipase activity, lysates are incubated with a substrate containing radiolabeled [9,10-3H(N)]-triolein. Subsequently, FA are extracted and quantitated by liquid scintilation counting. Data are presented as mean S.D. of triplicate determinations and representative for at least three independent experiments.
细胞实验	For MTT-based in vitro viability assays, cells are seeded in 96-well plates and cultured under standard conditions for 24 h. The next day, cells are pretreated with different concentrations of Atglistatin dissolved in DMSO or Cisplatin dissolved in DMF as positive control for 2 h. Medium is replaced by an identical fresh medium and incubated again for the indicated time points. Thereafter, cells are incubated for 3 h with 100 μL Thiazolyl Blue Tetrazolium Bromide (MTT). The resulting violet formazan crystals are dissolved by adding 100 μL of MTT solubilization solution (0.1% NP-40, 4 mM HCl and anhydrous isopropanol). After complete dissolution of the formazan product, absorbance is measured at 595 nm using 690 nm as reference wavelength.(Only for Reference)