326
36
3
1
336
4
Cat. No. | Product Name | ||
---|---|---|---|
L1400 | MAPK 抑制剂库 | 365 compounds | |
365 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合,可用于高通量筛选和高内涵筛选; | |||
L4100 | TGF-β/Smad靶点化合物库 | 184 compounds | |
184 个 TGF-β/Smad 靶点相关的小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L1300 | PI3K/Akt/mTOR 化合物库 | 420 compounds | |
420 种与PI3K/Akt/mTOR 相关的生物活性小分子化合物的特有集合,用于PI3K/Akt/mTOR 相关研究以及高通量、高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0001 |
Protease Inhibitor Cocktail (EDTA-Free, 100× in DMSO)
蛋白酶抑制剂 Cocktail (EDTA-Free, 100× in DMSO) |
Solution (EDTA-Free,100× in DMSO) | <em>Serine</em> proteases, Aminopeptidases, Cysteine proteases, Aspartic proteases |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35606 |
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium
1,2-Dioleoyl-sn-glycero-3-PS (sodium salt) |
Others | Others |
1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium (1,2-Dioleoyl-sn-glycero-3-PS (sodium salt)) 可与 DOPC 和 DOPE 一起用于脂质混合物中,作为有效的无毒和非病毒 DNA 载体。 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium 已用于单层囊泡的形成,以研究曲率对膜结构的影响,并用于支持脂质双层的形成,以研究各种支持膜小叶之间脂质重新分布的材料。 | |||
T40889 |
DMNB-caged-Serine
|
Others | Others |
DMNB-caged-Serine is a photocaged amino acid . DMNB is a caging group which is sensitive to blue light. DMNB-caged-Serine can be incorporated into proteins in Saccharomyces cerevisiae in response to the amber nonsense codon TAG, which can be helpful for controlling the chemical composition of mammalian proteins.. | |||
T33097 |
Lysyl-serine
|
Others | Others |
Lysyl-serine is a bioactive chemical. | |||
T36065 |
N-Oleoyl-L-Serine
|
||
Bone mass and shape is continuously remodeled by the concerted and balanced action of osteoblasts (bone forming cells) and osteoclasts (bone-resorbing cells). The endocannabinoid system plays an essential role in the maintenance of normal bone mass via signaling through the CB2 receptor. N-Oleoyl-L-serine is an endogenous lipid that has been reported to stimulate bone formation and to inhibit bone resorption. | |||
T33098 |
Lysyl-tyrosyl-serine acetate
|
Others | Others |
Lysyl-tyrosyl-serine acetate is a bioactive chemical. | |||
T66681 |
Glycyl-l-serine
|
Others | Others |
Glycyl-l-serine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66681,CAS号为 7361-43-5。 | |||
T66044 |
DL-Serine Hydrazide Hydrochloride
|
Others | Others |
DL-Serine Hydrazide Hydrochloride 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66044,CAS号为 55819-71-1。 | |||
T78174 |
Serine Hydrolase inhibitor-21
|
Others | Others |
Serine Hydrolase inhibitor-21(化合物8)为一种抑制丝氨酸水解酶的吡啶类化合物,其对BuChE的Ki值为429 nM,有望用于阿尔茨海默病的研究。 | |||
T65211 |
N-Cbz-DL-serine
|
||
N-Cbz-DL-serine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65211,CAS号为 2768-56-1。 | |||
T84551 |
N-Arachidonoyl-L-Serine
ARA-S |
Others | Others |
N-Arachidonoyl-L-serine (ARA-S), a recently isolated endocannabinoid with a distinct activity profile that diverges from typical endocannabinoids, does not interact with central cannabinoid (CB1), peripheral cannabinoid (CB2) receptors, or vanilloid receptor 1 (VR1). Unlike other compounds, ARA-S (5 mg/kg) counteracts the lowering of blood pressure induced by a 10 mg/kg intravenous bolus of abnormal cannabidiol (Abn-CBD) in anesthetized rat models. Additionally, akin to Abn-CBD, ARA-S induces re... | |||
T78617 |
N-Acetylserine
N-Acetyl-L-serine |
Endogenous Metabolite | Metabolism |
N-Acetylserine(N-Acetyl-L-serine)可与CysB脱辅基蛋白结合,作为半胱氨酸生物合成中的生理诱导剂。此外,该化合物能够刺激cysJIH基因在体外(in vitro)的转录。 | |||
T8350 |
TPCK
|
Proteasome | Proteases/Proteasome; Ubiquitination |
TPCK 是丝氨酸蛋白酶抑制剂,通过与 HPV-18 E7 蛋白的视网膜母细胞瘤蛋白 (RB) 结合核心发生反应,并能够消除其 RB 结合能力。将它添加到培养基内,可修饰活角质形成细胞中的 E7 蛋白。 | |||
T13408 |
ZK824190
|
Others; Serine Protease | Others; Proteases/Proteasome |
ZK824190 是具有口服活性尿激酶型纤溶酶原激活剂 (uPA) 选择性抑制剂,对 uPA,tPA 和 Plasmin 的IC50分别为 237,1600 和 1850 nM。ZK824190在多发性硬化症中有研究价值。 | |||
T7017 |
WNK463
|
Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism |
WNK463 是口服有活性的 WNK 激酶抑制剂,能够抑制 WNK1 (IC50:5 nM)、WNK2 (IC50:1 nM)、WNK3 (IC50:6 nM)及 WNK4 (IC50:9 nM)。 | |||
T11666 |
IPR-803
|
Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism |
IPR-803 是一种有效的 uPAR·uPA 蛋白-蛋白相互作用抑制剂,具有抗肿瘤活性。 IPR-803 直接与 uPAR 结合,Ki 为 0.2 μM。 | |||
TP1277 |
Bradykinin
缓激肽 |
Endogenous Metabolite; Bradykinin Receptor | GPCR/G Protein; Metabolism |
Bradykinin 是由激肽释放酶-激肽系统产生的活性肽。 它是炎症调节因子和神经调节因子,对几种血管和肾功能也有调节作用。 | |||
T11885 |
LSP-249
|
Others | Others |
LSP-249是血浆 kallikrein 的抑制剂,用于血管性水肿的研究,EC50值小于 100 nM。 | |||
T66377 |
N-Cbz-D-serine Methyl Ester
|
||
N-Cbz-D-serine Methyl Ester 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66377,CAS号为 93204-36-5。 | |||
T10547 |
BioE-1115
|
Serine/threonin kinase; Casein Kinase | Cell Cycle/Checkpoint; Metabolism; Stem Cells |
BioE-1115 是一种特异性和有效的丝氨酸-苏氨酸蛋白激酶抑制剂 (PASK, IC50 = 4 nM)。 BioE-1115 是一种有效的酪蛋白激酶 2α 抑制剂 (IC50 = 10 μM)。 | |||
T4058 |
R-IMPP
|
Others; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Others |
R-IMPP 是抗 PCSK9分泌的药物 (IC50=4.8 μM),靶向作用于 80S 核糖体,抑制 PCSK9 蛋白的翻译。 | |||
T13257 |
Upamostat
|
PAI-1; Serine/threonin kinase; Serine Protease | Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome |
Upamostat 是一种丝氨酸蛋白酶抑制剂,也是一种具有口服活性的 WX-UK1 前药,是一种尿激酶型纤溶酶原激活剂 (uPA) 抑制剂。 | |||
T25495 |
Hexadecylphosphoserine
Hexadecylphospho-L-serine,Hexadecyl phosphoserine,Hexadecyl-phosphoserine |
Others | Others |
Hexadecylphosphoserine is a representative growth inhibitor. | |||
T8362 |
Benzamidine hydrochloride
Benzamidine HCl,苄脒盐酸盐 |
Serine/threonin kinase; Serine Protease | Cell Cycle/Checkpoint; Metabolism; Proteases/Proteasome |
Benzamidine hydrochloride (Benzamidine HCl) 是可逆的胰蛋白酶样丝氨酸蛋白酶 (trypsin-like serine proteases) 竞争性抑制剂,对 uPA、类胰蛋白酶、胰蛋白酶和 Xa 因子作用的Ki 分别为 97 µM、20 µM、21 µM 和 110 µM。 | |||
T9920 |
Evolocumab
|
Others | Others |
Evolocumab 是人源化单克隆抗体PCSK9的抑制剂。它与循环的 PCSK9 蛋白结合,使得PCSK9与 LDLR 结合受到抑制。它可用研究于高胆固醇血症以及动脉粥样硬化性心血管疾病的研究。 | |||
T4524 |
SBC-110736
SBC110736 |
Others; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Others |
SBC-110736 是一种蛋白转化酶枯草杆菌蛋白酶 9 型 (PCSK9) 抑制剂。 | |||
T8645 |
PF-06446846
|
Others | Others |
PF-06446846 是口服有活性的 PCSK9抑制剂。它能够在密码子区域附近阻断 80S ribosome,选择性地直接抑制 PCSK9 的翻译。 | |||
T14358 |
Avoralstat
BCX4161 |
Others | Others |
Avoralstat (BCX4161) 是血浆激肽释放酶(PKK)抑制剂,具有口服活性,可用于遗传性血管性水肿的研究。 | |||
T21761 |
HNMPA
|
IGF-1R | Tyrosine Kinase/Adaptors |
HNMPA 是膜不可渗透的胰岛素受体酪氨酸激酶 (insulin receptor tyrosine kinase) 抑制剂。HNMPA 可以抑制人胰岛素受体的酪氨酸和丝氨酸自磷酸化。HNMPA 对环 AMP 依赖性蛋白激酶或蛋白激酶 C 活性没有影响。 | |||
T9276 |
SBC-115337
|
Others; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Others |
SBC-115337 是苯并呋喃化合物,也是 PCSK9抑制剂 (IC50:0.5 μM) 。 | |||
T8676 |
FOY 251
|
Others; Serine/threonin kinase; SARS-CoV | Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Others |
FOY 251 是一种蛋白酶抑制剂,是具有抗蛋白水解活性的 Camostate 代谢物,能抑制 SARS-CoV-2 的感染。 | |||
T5456 |
WNK-IN-11
Allosteric WNK Kinase Inhibitor |
Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism |
WNK-IN-11 (Allosteric WNK Kinase Inhibitor) 是(WNK)激酶的变构抑制剂,能够抑制 WNK1 (IC50:4 nM) 。 | |||
T6370 |
AEBSF hydrochloride
AEBSF HCl,Pefabloc SC |
Thrombin; Serine Protease; Influenza Virus | Microbiology/Virology; Proteases/Proteasome |
AEBSF hydrochloride (Pefabloc SC) 是一种丝氨酸蛋白酶的不可逆抑制剂。 | |||
T2626 |
SBC-115076
SBC115076 |
Others; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Others |
SBC-115076 是前蛋白转化酶枯草杆菌蛋白酶/ kexin 9型(PCSK9)抑制剂。其中PCSK9 是一种前蛋白转化酶,在 LDL 受体代谢中的重要物质。 | |||
T63847 |
1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium
|
Others | Others |
Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) 是一种改性 PS 产品,经由 NADPH 氧化酶激活及 Lyso-PS 信号转导后得到。Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium 能够利用巨噬细胞 G2A 功能,增强现有的受体/配体系统,进而解决中性粒细胞炎症。 | |||
T3359 |
Aprotinin
抑酶肽,抑肽酶,Bovine Pancreatic Trypsin Inhibitor,Traskolan,Antilysin |
Others; Serine Protease; Influenza Virus; Proteasome | Microbiology/Virology; Others; Proteases/Proteasome; Ubiquitination |
Aprotinin (Traskolan) 是分离自牛肺的一种广谱丝氨酸蛋白酶抑制剂,可抑制多种不同酯酶和蛋白酶的活性。 | |||
T2392 |
Nafamostat mesylate
甲磺酸萘莫司他,FUT-175 |
Apoptosis; Serine/threonin kinase; SARS-CoV; Serine Protease | Apoptosis; Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Nafamostat mesylate (FUT-175) 是一种广谱丝氨酸蛋白酶抑制剂,血管舒缓素抑制剂,能抑制血液凝固。它通过降低颗粒酶活性和 CTL 细胞溶解抑制T 细胞自身反应活性,可抑制SARS-CoV-2 的激活。它还是潜在的补体抑制剂。 | |||
T31206 |
Darexaban
YM 150,Darexaban, Tanexaban,YM150 |
Factor Xa | Metabolism |
Darexaban (Tanexaban, YM-150) 是选择性的、口服具有活力的 Xa 因子 (FXa) 抑制剂,IC50=54.6 nM。它对其他相关丝氨酸蛋白酶(如胰蛋白酶、凝血酶和激肽释放酶)具有高选择性。它具有抗凝和抗血栓形成作用。 | |||
T8866 |
GW779439X
|
Apoptosis; Antibacterial; CDK; Aurora Kinase | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Microbiology/Virology |
GW779439X 属于吡唑并吡啶类,是一种金黄色葡萄球菌 PASTA 激酶 Stk1抑制剂。它是一种AURKA 抑制剂,可通过 caspases 3/7 诱导细胞凋亡。 | |||
T8574 |
SPHINX
|
Others | Others |
SPHINX 是新一代的 SPRK1抑制剂。 | |||
T3990 |
AA26-9
|
Phospholipase; Serine Protease | Metabolism; Proteases/Proteasome |
AA26-9 是广谱丝氨酸水解酶的高效抑制剂。它的靶点包括丝氨酸肽酶、酰胺酶、脂肪酶、酯酶和硫酯酶。在永生化 T 细胞系,检测到它对 40+ 丝氨酸水解酶中的 1/3 有抑制作用。 | |||
T50103 |
NFAT Inhibitor-2
|
Others; Calcium Channel | Membrane transporter/Ion channel; Metabolism; Others |
NFAT Inhibitor-2 是是钙调磷酸酶 NFAT 信号传导的强效抑制剂。 | |||
T19763 |
Cetraxate hydrochloride
DV-1006,DV 1006,Cetraxate HCl,盐酸西曲酸酯,DV1006 |
Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism |
Cetraxate hydrochloride (DV10062) 是一种有效的顶体蛋白酶 (acrosomal proteinase acrosin) 抑制剂,Ki 和 IC50分别为 0.94 μM 和 3.3 μM。它是一种口服有活性的抗溃疡试剂 (anti-ulcer),具有粘膜保护作用,可用于研究胃溃疡。 | |||
T8936 |
Proteinase K
proteinase K for tritirachium album,Protease K,蛋白酶 K |
Others | Others |
Proteinase K (proteinase K for tritirachium album) 是一种非特异性丝氨酸蛋白酶,可用于蛋白消化。它在有 SDS 或尿素存在的情况下,在很大 pH 值 (4-12)、盐浓度和温度单位内均有活性。 | |||
T15802 |
LY2183240
|
FAAH; Autophagy | Autophagy; Metabolism; Neuroscience |
LY2183240 是大麻素摄取阻滞剂。它是内源性大麻素降解酶脂肪酸酰胺水解酶的有效共价抑制剂。它抑制脂肪酸酰胺水解酶 (FAAH) 活性,IC50 为12.4 nM。它也抑制其他几种脑丝氨酸水解酶,对 MAG 脂肪酶、bh6 和 KIAA1363 的 IC50分别为 5.3、0.09 和 8.2 nM。 | |||
T1954 |
SRPIN340
SRPK inhibitor |
Virus Protease; Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology |
SRPIN340 (SRPK inhibitor) 是 ATP 竞争性 SRPK 抑制剂,能够抑制 SRPK1 活性,Ki 值为 0.89 μM。 | |||
T2391 |
Camostat mesylate
FOY-S980,甲磺酸卡莫司他,FOY305,Camostat mesilate |
Serine/threonin kinase; SARS-CoV; Sodium Channel | Cell Cycle/Checkpoint; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Camostat mesylate (FOY-S980) 是口服活性合成的丝氨酸蛋白酶抑制剂,用于慢性胰腺炎。它是TMPRSS2的抑制剂,对SARS-CoV-2具有抗病毒活性。它抑制前列腺素、胰蛋白酶和苦参多糖的活性。 | |||
T40495 |
Elastase from porcine pancreas
弹性蛋白酶,EC 3.2.1.35 |
Others | Others |
Elastase from porcine pancreas 由 240 个氨基酸残基组成,是一种丝氨酸蛋白酶,可以水解蛋白质和多肽。它可诱发仓鼠气肿。 | |||
T5194 |
SPHINX31
|
Serine/threonin kinase | Cell Cycle/Checkpoint; Metabolism |
SPHINX31 是丝氨酸/富含精氨酸的蛋白激酶1的选择性抑制剂,其IC50值为 5.9 nM。它有效抑制丝氨酸/丰富精氨酸的剪接因子1 磷酸化,有用于局部新生血管性眼病的研究潜力。 | |||
T5125 |
LY3200882
|
TGF-beta/Smad | Stem Cells |
LY3200882 是一种高度选择性的、口服活性的、具有 ATP 竞争性的 TGF-β 受体 1 型 (ALK5) 抑制剂(IC50:38.2 nM)。它能够抑制多种促肿瘤活性,可用作免疫调节剂。 | |||
T9374 |
AA38-3
1-Piperidinecarboxylic acid, 4-nitrophenyl ester |
FAAH; Lipase; MAGL | Metabolism; Neuroscience |
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) 是丝氨酸水解酶抑制剂,能够抑制三种 SHs:ABHD6,ABHD11 和 FAAH。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2O2730 |
L-Serine
(S)-Serine,L-丝氨酸,丝氨酸,serine,(-)-Serine,(S)-2-Amino-3-hydroxypropanoic acid |
Endogenous Metabolite | Metabolism |
L-Serine (serine) 是一种人体非必需氨基酸,它存在于许多蛋白质中,并且在功能上很重要。L-Serine 也存在于丝氨酸蛋白酶类的活性位点,包括胰蛋白酶和凝乳胰蛋白酶。 | |||
T8394 |
D-Serine
(R)-Serine,D-丝氨酸 |
Endogenous Metabolite; NMDAR; iGluR | Membrane transporter/Ion channel; Metabolism; Neuroscience |
D-Serine ((R)-Serine) 是一种具有独特的神经递质特性的神经胶质-突触相互作用中涉及的内源性氨基酸,是 NMDA 谷氨酸受体的有效共激动剂。D-Serine 在主要的 NMDAR 依赖性过程中具有主要的调节作用,包括 NMDAR 介导的神经传递,神经毒性,突触可塑性和细胞迁移。 | |||
T8363 |
DL-Serine
|
PKM | Metabolism |
DL-Serine 是 D-丝氨酸和 L-丝氨酸的混合物,是一种基础代谢物。它具有抗病毒作用,能抑制烟草花叶病毒的增殖。 | |||
T1324 |
O-Phospho-L-serine
L-Serine O-phosphate,磷酸化丝氨酸,Phosphoserine,Dexfosfoserine,L-SOP |
Amino Acids and Derivatives; Endogenous Metabolite; GluR; NMDAR | Metabolism; Neuroscience |
O-Phospho-L-serine (Phosphoserine) 是 L-serine 合成过程中的直接前体物质,是 mGluR 激动剂。 | |||
T4722 |
O-Acetyl-L-serine hydrochloride
|
Others; Endogenous Metabolite | Metabolism; Others |
O-Acetyl-L-serine hydrochloride 是内源性代谢产物的一种。 | |||
T8095 |
O-Acetylserine
O-乙酰-L-丝氨酸,O-Acetyl-L-serine,O-乙醯絲胺酸 |
Others; Endogenous Metabolite | Metabolism; Others |
O-Acetylserine (O-Acetyl-L-serine) 是细菌和植物中半胱氨酸合成过程中的中间体。 | |||
TQ0158 |
Azaserine
CI-337,偶氮丝胺酸,P-165,氮杂丝氨酸,O-Diazoacetyl-L-serine |
Others; Antibiotic | Microbiology/Virology; Others |
Azaserine (CI-337) 是一种从链霉菌属中分离出来的肿瘤抑制抗生素,可作为谷氨酰胺氨基转移酶的抑制剂。 | |||
T5057 |
DL-O-Phosphoserine
DL-O-磷酸丝氨酸,DL-2-Amino-3-hydroxypropanoic acid 3-phosphate,O-PHOSPHO-L-SERINE,DL-SOP |
Others; Endogenous Metabolite | Metabolism; Others |
O-PHOSPHO-L-SERINE 是丝氨酸和磷酸的酯,是人类生物流体中的正常代谢物。O-phospho-L-serine 是一种吞噬抑制剂,抑制光损伤后的神经胶质细胞增殖和锥体细胞再生。 | |||
TN2082 |
Pinostrobin
|
Beta Amyloid; IL Receptor; Serine/threonin kinase; TNF | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; Metabolism; Neuroscience |
Pinostrobin 是一种 PCSK9抑制剂,可抑制 PCSK9 的催化活性。它是能够在多种植物中发现的黄酮类化合物,并具有抗氧化,抗炎,抗癌和神经保护作用。它是有前景的胆固醇调节和脂质管理剂。 | |||
T5S0689 |
Demethylwedelolactone
去甲蟛蜞菊内酯,去甲基蟛蜞内酯 |
Serine Protease | Proteases/Proteasome |
Demethylwedelolactone 是一种分离自 Eclipta alba 中的 coumestan 天然产物。它能抑制乳腺癌细胞的移动和侵袭,是一种有效的trypsin 抑制剂(IC50:3.0 μM)。 | |||
T4757 |
L-Homoserine
(S)-2-氨基-4-羟基丁酸,(S)-(-)-2-AMINO-4-HYDROXYBUTYRIC ACID |
Others; Endogenous Metabolite | Metabolism; Others |
L-Homoserine ((S)-(-)-2-AMINO-4-HYDROXYBUTYRIC ACID) 是天然存在的非蛋白丝氨酸,是合成苏氨酸、蛋氨酸和赖氨酸的共有中间体。它是氨基酸丝氨酸的更具反应性的变体。 | |||
T0710 |
L-Cycloserine
Levcycloserine,Levcicloserina,(-)-Cycloserine,(S)-Cycloserine,Levcycloserinum,环丝氨酸,(S)-4-Amino-3-isoxazolidone |
HIV Protease; GABA Receptor | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
L-Cycloserine ((-)-Cycloserine) 不可逆地抑制大肠杆菌以及各种动物大脑中的 GABA 吡哆醛 5'-磷酸依赖性转氨酶,导致体内抑制性神经递质 γ-氨基丁酸水平升高。 | |||
T4704 |
L-Anserine nitrate
L-鹅肌肽硝酸盐,L-Anserine nitrate salt |
Others; Endogenous Metabolite | Metabolism; Others |
L-Anserine nitrate (L-Anserine nitrate salt) 是一种存在于大多数动物组织中的二肽。在模型系统中,它是一种有效的抗氧化剂和羟基自由基清除剂。该化合物抑制醛糖和酮糖还原糖诱导的非酶蛋白糖基化。 | |||
T1589 |
D-Cycloserine
RO-1-9213,D-环丝氨酸 |
Others; Antibacterial; Antibiotic; iGluR | Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others |
D-Cycloserine (RO-1-9213) 是一种抗生素,靶向细菌细胞壁肽聚糖生物合成酶。它是一种NMDA 部分激动剂,可以改善认知功能,可研究耐多药结核病。 | |||
T7054 |
N-Benzoyl-(2R,3S)-3-phenylisoserine
N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸,taxol side chain |
Antiviral | Immunology/Inflammation |
N-Benzoyl-(2R,3S)-3-phenylisoserine (taxol side chain) 是一种制备用于研究结合位点位置的强效抗癌药物紫杉醇的中间体。 它显示出细胞毒性、抗病毒和免疫调节活性。 | |||
T81722 |
N-(3-Oxodecanoyl)-L-homoserine lactone
3-Oxo-C10-HSL |
||
N-(3-Oxodecanoyl)-L-homoserine lactone (3-Oxo-C10-HSL) 作为一种信号分子,在细菌群体感应中充当自诱导分子的角色。 | |||
T35577 |
Phosphatidylserines (bovine)
|
Others | Others |
Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina. It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine or phosphatidylethanolamine by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversi... | |||
T19440 |
N-(3-Oxooctanoyl)-DL-homoserine lactone
(Rac)-3-oxo-C8-HSL |
Others | Others |
N-(3-Oxooctanoyl)-DL-homoserine lactone with stereochemistry-dependent growth regulatory activity for roots . | |||
T8276 |
Methyl palmitoleate
|
Others | Others |
Methyl palmitoleate 是棕榈油酸的类似物,也是一种脂肪酸甲酯,具有细胞保护性和促进生长性。 | |||
T7444 |
6-(Dimethylamino)purine
N,N-Dimethyladenine,6-二甲基氨基嘌呤 |
Serine/threonin kinase; CDK | Cell Cycle/Checkpoint; Metabolism |
6-(Dimethylamino)purine (N,N-Dimethyladenine) 是一种丝氨酸苏氨酸蛋白激酶和 CDK 抑制剂。 | |||
T5085 |
Pyridoxal 5'-phosphate hydrate
Codecarboxylase,Pyridoxal 5'-phosphate hydrate(1:x),5-磷酸吡多醛水合物,PLP,Pyridoxal 5'-phosphate hydrate |
Others; Endogenous Metabolite | Metabolism; Others |
Pyridoxal 5'-phosphate hydrate (PLP) 是内源性代谢产物的一种。 | |||
T9143 |
D-Isoleucine
(2R,3R)-2-Amino-3-methylpentanoic acid,D-异亮氨酸,(R)-Isoleucine |
Others | Others |
D-Isoleucine ((2R,3R)-2-Amino-3-methylpentanoic acid) 是一种异亮氨酸立体异构体,是 Asc-1 反转运蛋白的选择性激活剂。它能够释放内源性 D-丝氨酸,提高海马 CA1-CA3 的长期增效作用。 | |||
T4915 |
β-Glycerophosphate disodium salt hydrate
|
Phosphatase; Endogenous Metabolite | Metabolism |
β-Glycerophosphate disodium salt hydrate 是一种磷酸酶抑制剂,是内源性代谢产物的一种。 | |||
T4713 |
Phosphorylcholine chloride calcium salt tetrahydrate
Phosphocholine chloride calcium salt tet,胆碱磷酸氯化钙四水,CalciuM Phosphorylcholine Tetrahydrate |
Others; Endogenous Metabolite | Metabolism; Others |
Phosphorylcholine chloride calcium salt tetrahydrate (Phosphocholine chloride calcium salt tet) 是内源性代谢产物的一种。 | |||
T16165 |
Myriocin
ISP-I,Thermozymocidin |
HCV Protease; Antifungal | Microbiology/Virology; Proteases/Proteasome |
Myriocin (Thermozymocidin) 是一种从 Myriococcum albomyces 中得到的代谢产物,是一种丝氨酸-棕榈酰转移酶 (SPT) 抑制剂,具有潜在的抗肿瘤抗癌和抗寄生虫活性,通过 PI3K/Akt/mTOR 通路调节巨噬细胞极化和功能来抑制肿瘤生长。Myriocin 抑制 HCV 感染,可用于研究神经病变和真菌感染。 | |||
TN6872 |
Trypsin
|
Protease-activated Receptor | GPCR/G Protein |
Trypsin 是一种可从鱼类分离出的丝氨酸蛋白酶,可水解赖氨酸或精氨酸羧基侧蛋白质。Trypsin 具有抗炎活性,可通过 PDCoV 的 S 糖蛋白与 pAPN 的相互作用诱导 PDCoV 感染的细胞膜融合,可激活 PAR2 和 PAR4,促进细胞增殖和分化。Trypsin 可用于促进伤口愈合和研究神经源性炎症。 | |||
T4839 |
Ac-Ala-OH
N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。 | |||
T4825 |
D-(+)-Xylose
D(+)-Xylose,木糖,(+)-Xylose,Wood sugar |
Endogenous Metabolite | Metabolism |
D-(+)-Xylose (Wood sugar) 是一种是一种戊醛糖,其化学式为C5H10O5,甜度为蔗糖的40%。木糖也存在于结缔组织的粘多糖中,有时也存在于尿液中。 | |||
T24412 |
Lipoxamycin
G 26146,G-26146,G26146,Neoenactin M1 |
Others | Others |
Lipoxamycin is an inhibitor of serine palmitoyl-transferase. | |||
T19365 |
Hydroxypyruvic acid
3-Hydroxypyruvic acid,β-Hydroxypyruvic acid |
Others | Others |
Hydroxypyruvic acid is an intermediate in the metabolism of glycine, serine, and threonine. It is a substrate for serine-pyruvate aminotransferase and glyoxylate reductase/hydroxypyruvate reductase. | |||
T75648 |
Rivulariapeptolides 1155
|
Others | Others |
Rivulariapeptolides 1155 是一种有效的丝氨酸蛋白酶 (serine protease) 抑制剂,对糜蛋白酶、弹性蛋白酶、蛋白蛋白酶 K 的 IC50分别为 41.84、4.94、56.54 nM。 | |||
T16381 |
Okadaic acid
|
Others | Others |
Okadaic acid is a non-comepetitive, selective and reversible serine/threonine-specific protein phosphatases 1 (PP1), PP2A, and PP3 inhibitor (IC50s: 10-15 nM, 0.5 nM, and 4 nM, respectively). Okadaic acid is extracted from black sponges of the genus Halic | |||
T75649 |
Rivulariapeptolides 1185
|
Others | Others |
Rivulariapeptolides 1185 是一种高效的选择性丝氨酸蛋白酶抑制剂,其对胰凝蛋白酶、弹性蛋白酶和蛋白酶 K 的 IC50分别为 13.17 nM、23.59 nM 和 55.26 nM。 | |||
T75652 |
Molassamide B
|
Others | Others |
Molassamide B,丝氨酸蛋白酶抑制剂,对胰凝乳蛋白酶、弹性蛋白酶及蛋白酶 K 具有显著抑制活性,其IC50值分别为24.65、11.69和5.42 nM。 | |||
T75651 |
Rivulariapeptolides 988
|
Others | Others |
Rivulariapeptolides 988作为一种高效选择性丝氨酸蛋白酶抑制剂,对胰凝蛋白酶、弹性蛋白酶和蛋白酶K的IC50分别为95.46 nM、15.29 nM和85.50 nM。 | |||
T75650 |
Rivulariapeptolides 1121
|
Others | Others |
Rivulariapeptolides 1121,作为一种高效的选择性丝氨酸蛋白酶抑制剂,对胰凝蛋白酶、弹性蛋白酶和蛋白酶K展示出了显著的抑制活性,其IC50值分别为35.52 nM、13.24 nM和48.05 nM。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-02083 |
Serine racemase/SRR Protein, Human, Recombinant (His & SUMO)
L-serine ammonia-lyase,D-serine ammonia-ly... |
Human | E. coli |
Serine racemase/SRR Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-03468 |
D-serine dehydratase Protein, Salmonella heidelberg, Recombinant (His & SUMO)
D-serine deaminase,dsdA,DSD,D-serine dehyd... |
Salmonella heidelberg | E. coli |
D-serine dehydratase Protein, Salmonella heidelberg, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 63.3 kDa and the accession number is B4TA53. | |||
TMPY-02078 |
HtrA2/Omi Protein, Human, Recombinant (His)
PARK13,OMI,HtrA serine peptidase 2,PRSS25 |
Human | E. coli |
Serine protease HTRA2, also known as high-temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass membrane protein that belongs to the peptidase S1B family. HTRA2 contains one PDZ (DHR) domain. HTRA2 is a serine protease that shows proteolytic activity against a non-specific substrate beta-casein. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor... | |||
TMPY-02731 |
SPINK4 Protein, Mouse, Recombinant (hFc)
MPGC60,serine peptidase inhibitor, Kazal type 4,RP2... |
Mouse | HEK293 Cells |
SPINK4 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 34.5 kDa and the accession number is O35679. | |||
TMPH-02895 |
Serpin A3K Protein, Mouse, Recombinant (His)
Contrapsin,SPI-2,Serpina3k,Serine protease inhibito... |
Mouse | P. pastoris (Yeast) |
Contrapsin inhibits trypsin-like proteases. Serpin A3K Protein, Mouse, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 45.7 kDa and the accession number is P07759. | |||
TMPY-01897 |
PRSS3 Protein, Human, Recombinant (His)
PRSS4,TRY4,TRY3,RP11-176F3.3,T9,MTG,protease, serine |
Human | HEK293 Cells |
Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their ... | |||
TMPY-05159 |
Granzyme A/GZMA Protein, Human, Recombinant (His)
CTLA3,granzyme A (granzyme 1, cytotoxic T-lymphocyte-associa... |
Human | HEK293 Cells |
Granzyme A/GZMA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.5 kDa and the accession number is P12544-1. | |||
TMPY-01059 |
BMPR2 Protein, Human, Recombinant (His)
POVD1,PPH1,BMPR3,BRK-3,BMPR-II,bone morphogenetic protein re... |
Human | HEK293 Cells |
BMPR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.6 kDa and the accession number is Q13873. | |||
TMPY-04997 |
Prostasin/PRSS8 Protein, Rat, Recombinant (His)
protease, serine, 8 |
Rat | HEK293 Cells |
Prostasin/PRSS8 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.9 kDa and the accession number is Q9ES87. | |||
TMPJ-00484 |
SHMT1 Protein, Human, Recombinant (His)
Serine Methylase,Glycine Hydroxymethyltransferase,<... |
Human | HEK293 Cells |
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to ... | |||
TMPH-02894 |
HTRA1 Protein, Mouse, Recombinant (His)
Serine protease 11,Serine protease HTRA1,H... |
Mouse | E. coli |
HTRA1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 39.0 kDa and the accession number is Q9R118. | |||
TMPH-02236 |
TMPRSS2 Protein, Human, Recombinant (E. coli, His)
Transmembrane protease serine 2,TMPRSS2,Serine<... |
Human | E. coli |
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.... | |||
TMPH-02237 |
TMPRSS2 Protein, Human, Recombinant (His & Myc)
Serine protease 10,Transmembrane protease serin... |
Human | HEK293 Cells |
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.... | |||
TMPY-00274 |
Enterokinase Protein, Bovine, Recombinant (His)
transmembrane protease, serine 15 |
Bovine | P. pastoris (Yeast) |
Enterokinase Protein, Bovine, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 27.1 kDa and the accession number is P98072-1. | |||
TMPY-04928 |
TMPRSS11B Protein, Human, Recombinant (His)
transmembrane protease, serine 11B |
Human | HEK293 Cells |
TMPRSS11B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.3 kDa and the accession number is CAD91168.1. | |||
TMPH-02081 |
HTRA1 Protein, Human, Recombinant (His & SUMO)
Serine protease HTRA1,HTRA1,Serine proteas... |
Human | E. coli |
HTRA1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-02238 |
TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated
TMPRSS2,Transmembrane protease serine 2,Serine<... |
Human | E. coli |
TMPRSS2 Protein, Human, Recombinant (Avi & His & MBP), Biotinylated is expressed in E. coli expression system with N-MBP and C-6xHis-Avi tag. The predicted molecular weight is 90.6 kDa and the accession number is O15393. | |||
TMPH-02235 |
TMPRSS2 Protein, Human, Recombinant (Cell-Free, His)
Transmembrane protease serine 2,Serine pro... |
Human | E. coli |
TMPRSS2 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 46.9 kDa and the accession number is O15393. | |||
TMPY-00817 |
Granzyme B/GZMB Protein, Human, Recombinant (His)
CGL1,CTLA1,CSP-B,CTSGL1,HLP,SECT,CSPB,granzyme B (granzyme 2... |
Human | HEK293 Cells |
Granzyme B, also known as GZMB, is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B enters the target cells depending on another membrane-binding granule protein, perforin, results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Over 3 substrates of G... | |||
TMPY-04985 |
TMPRSS11D Protein, Human, Recombinant (His)
transmembrane protease, serine 11D,HAT |
Human | HEK293 Cells |
TMPRSS11D (HAT) belongs to the large type II transmembrane serine protease (TTSP) family, participating in various biological and physiological processes. TMPRSS11D protein expression in tumorous tissues were correlated with NSCLC patients' clinical characteristics and overall survival. Both TMPRSS11D mRNA and protein expression levels were significantly higher in NSCLC tumorous tissues than in adjacent normal tissues. High TMPRSS11D protein expression was associated with high TNM stages, and hi... | |||
TMPJ-01320 |
BSSP-4 Protein, Human, Recombinant (His)
BSSP4,Tryptase ε,Serine Protease 26,BSSP-4,Seri... |
Human | HEK293 Cells |
Brain-Specific Serine Protease 4 (BSSP-4) is a serine protease that preferentially cleaves the synthetic substrate H-D-Leu-Thr-Arg-pNA compared to tosyl-Gly-Pro-Arg-pNA. BSSP-4 is expressed abundantly in the epithelial cells of the airways, including trachea, esophagus and fetal lung, but scarce in adult lung and expressed at low levels in placenta, pancreas, prostate and thyroid gland. BSSP-4 belongs to the peptidase S1 family and related to trypsin, referentially hydrolyzing substrates after a... | |||
TMPH-02408 |
SPI Protein, Lentinula edodes, Recombinant (His)
Serine protease inhibitor |
Lentinula edodes | E. coli |
Serine protease inhibitor. Active against beta-trypsin and alpha-chymotrypsin with dissociation constants of 0.35 nM and 40 nM respectively. Inhibits factor XIa, but not other enzymes involved in coagulation and fibrinolysis. Does not inhibit subtilisin, lysyl endopeptidase, arginyl endopeptidase or papain. | |||
TMPH-03326 |
MASP2 Protein, Rat, Recombinant (His)
Mannan-binding lectin serine protease 2,MBL-associa... |
Rat | Baculovirus Insect Cells |
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase. MASP2 Protein, Rat, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 79.2 kDa and the accession number is Q9JJS8. | |||
TMPH-02553 |
BSSP-4 Protein, Mouse, Recombinant (His)
Serine protease 26,Brain-specific serine p... |
Mouse | E. coli |
N/A. BSSP-4 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.9 kDa and the accession number is Q9ER10. | |||
TMPH-03572 |
SplB Protein, S. aureus, Recombinant (His & Myc)
splB,Serine protease SplB |
Staphylococcus aureus | E. coli |
Serine protease that cleaves specifically after the sequence Trp-Glu-Leu-Gln. SplB Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 29.8 kDa and the accession number is A7X3Q8. | |||
TMPH-02080 |
PRSS56 Protein, Human, Recombinant (His & Myc)
PRSS56,Serine protease 56 |
Human | E. coli |
PRSS56 Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPY-00905 |
Prostasin/PRSS8 Protein, Human, Recombinant (His)
CAP1,protease, serine, 8,PROSTASIN |
Human | HEK293 Cells |
Prostasin/PRSS8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.8 kDa and the accession number is Q16651-1. | |||
TMPH-02644 |
Enteropeptidase Protein, Mouse, Recombinant (His & SUMO)
Tmprss15,Entk,Enterokinase,Serine protease 7,Prss7,... |
Mouse | E. coli |
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. Enteropeptidase Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.0 kDa and the accession number is P97435. | |||
TMPH-03573 |
SplD Protein, S. aureus, Recombinant (His & Myc)
Serine protease SplD,splD |
Staphylococcus aureus | E. coli |
SplD Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 29.5 kDa and the accession number is Q2FXC5. | |||
TMPH-01617 |
SDS Protein, Human, Recombinant (His & Myc)
L-serine dehydratase/L-threonine deaminase,L-threon... |
Human | E. coli |
SDS Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPY-05026 |
RISC Protein, Human, Recombinant (His)
serine carboxypeptidase 1,HSCP1,RISC |
Human | HEK293 Cells |
RISC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.4 kDa and the accession number is Q9HB40-1. | |||
TMPH-02643 |
Enteropeptidase Protein, Mouse, Recombinant (His & Myc)
Serine protease 7,Prss7,Transmembrane protease ... |
Mouse | HEK293 Cells |
Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. | |||
TMPY-04407 |
LOK Protein, Human, Recombinant (His)
serine/threonine kinase 10,PRO2729,LOK |
Human | E. coli |
Serine / threonine-protein kinase 1, also known as Lymphocyte-oriented kinase, STK1 and LOK, belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE2 subfamily. Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. The Ste2 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. STK1 is si... | |||
TMPY-04466 |
STK40 Protein, Human, Recombinant (His & GST)
SHIK,SgK495,serine/threonine kinase 40 |
Human | Baculovirus Insect Cells |
STK40 is localized to both the cytoplasm and the nucleus. It is ubiquitously expressed. Mechanistically, Stk40 interacts with Rcn2, which also activates Erk1/2 to induce ExEn specification in mouse ESCs. Stk40 is able to activate the Erk/MAPK pathway and induce extraembryonic-endoderm (ExEn) differentiation in mouse ESCs. Interestingly, cells overexpressing Stk40 exclusively contribute to the ExEn layer of chimeric embryos when injected into host blastocysts. In contrast, deletion of Stk40 in ES... | |||
TMPH-01638 |
MASP1 Protein, Human, Recombinant (His & SUMO)
MASP1,Mannose-binding lectin-associated serine prot... |
Human | E. coli |
MASP1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 93.0 kDa and the accession number is P48740. | |||
TMPH-02239 |
TMPRSS4 Protein, Human, Recombinant (His & Myc)
Channel-activating protease 2,TMPRSS4,Transmembrane protease... |
Human | E. coli |
Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC.; (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. TMPRSS4 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10... | |||
TMPH-02896 |
Serpin A3N Protein, Mouse, Recombinant (His & SUMO)
Serpina3n,Serine protease inhibitor A3N |
Mouse | E. coli |
Serpin A3N Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 60.8 kDa and the accession number is Q91WP6. | |||
TMPY-04500 |
RISC Protein, Mouse, Recombinant (His)
2410018F01Rik,4833411K15Rik,serine carboxypeptidase... |
Mouse | HEK293 Cells |
RISC Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.3 kDa and the accession number is Q920A5. | |||
TMPY-04374 |
MST4 Protein, Human, Recombinant (GST)
serine/threonine protein kinase 26,MST4,MASK |
Human | Baculovirus Insect Cells |
MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains a C-terminal regulatory domain and an N-terminal kinase domain, both of which are required for full activation of the kinase. MST4 is highly expressed in the placenta, thymus, and peripheral blood leukocytes. MST4 specifically activates ERK but not JNK or p38 MAPK in transiently ... | |||
TMPH-02899 |
VRK1 Protein, Mouse, Recombinant (His & Myc)
Vaccinia-related kinase 1,Serine/threonine-protein ... |
Mouse | E. coli |
VRK1 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-6xHis and C-Myc tag. The predicted molecular weight is 55.2 kDa and the accession number is Q80X41. | |||
TMPJ-01282 |
Serpin B12 Protein, Human, Recombinant (His)
SERPINB12,Serine Protease Inhibitor-clade B12,Serpi... |
Human | HEK293 Cells |
Serpin B12 is a member of the serpin family. Serpins are the largest and most diverse family of serine protease inhibitors. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular fluids. Serpin B12 is expressed in many tissues, including brain, bone marrow, lymph node, heart, lung, liver, pancreas, testis, ovary, and intestine. Serpins are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysi... | |||
TMPY-02117 |
Marapsin Protein, Human, Recombinant (His)
UNQ1884/PRO4327,protease, serine 27,CAPH2,MPN |
Human | HEK293 Cells |
The name "Pancreasin" because it is transcribed strongly in the pancreas. This secreted, tryptic serine protease, also known as Marapsin or PRSS27 (Protease, serine, 27), is a member of the peptidase S1 family. Pancreasin is inhibited by benzamidine and leupeptin but resists several classic inhibitors of trypsin. Marapsin was constitutively expressed in nonkeratinizing stratified squamous epithelia of human esophagus, tonsil, cervix, larynx, and cornea. In fact, marapsin was the second most stro... | |||
TMPH-03458 |
STE11 Protein, S. cerevisiae, Recombinant
Serine/threonine-protein kinase STE11,STE11 |
Saccharomyces cerevisiae | E. coli |
Serine/threonine protein kinase required for cell-type-specific transcription and signal transduction in yeast. It is thought that it phosphorylates the STE7 protein kinase which itself, phosphorylates the FUS3 and or KSS1 kinases. STE11 Protein, S. cerevisiae, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.5 kDa and the accession number is P23561. | |||
TMPH-02086 |
SRSF3 Protein, Human, Recombinant (GB1 & His)
Serine/arginine-rich splicing factor 3,Pre-mRNA-spl... |
Human | E. coli |
SRSF3 Protein, Human, Recombinant (GB1 & His) is expressed in E. coli. | |||
TMPH-02898 |
SPINK2 Protein, Mouse, Recombinant (His & Myc)
Serine protease inhibitor Kazal-type 2,Spink2 |
Mouse | E. coli |
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis. It also inhibits trypsin. SPINK2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 15.0 kDa and ... | |||
TMPJ-01253 |
Serpin A3N Protein, Mouse, Recombinant (His)
Serpina3n,Serine protease inhibitor A3N,Spi2,Serpin... |
Mouse | HEK293 Cells |
Serine protease inhibitor A3N(Serpin A3N) is a serine protease inhibitor that is structurally related to α1 antichymotrypsin encoded by the SERPINA3 gene. Serpin A3N is highly expressed in brain, testis, lung, thymus, and spleen. It is expressed with low levels in bone marrow, kidney and skeletal muscle. Serpin A3N secreted by Sertoli cells may regulate the activity of locally produced Granzyme B. Granzyme B inhibition by Serpin A3N may therefore regulate Granzyme Bmediated killing by cytotoxic ... | |||
TMPH-02897 |
SPINK1 Protein, Mouse, Recombinant (His)
Serine protease inhibitor Kazal-type 3,Serine |
Mouse | P. pastoris (Yeast) |
Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens.; In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production. SPINK1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 8.1 kDa and the accession number is P09036. | |||
TMPH-03587 |
GspB Protein, S. gordonii, Recombinant (GST)
Serine-rich adhesin for platelets,Serine-r... |
Streptococcus gordonii | E. coli |
Plays a role in virulence and host-pathogen interactions. Mediates binding to human platelets via interaction with the human cell surface glycoprotein GP1BA. Plays a positive role in biofilm formation, possibly by self-association via the basic region (BR). GspB Protein, S. gordonii, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 68.5 kDa and the accession number is Q939N5. | |||
TMPH-02256 |
Trypsin-3 Protein, Human, Recombinant (His)
Trypsin III,Mesotrypsinogen,PRSS3,Trypsin-3,Serine ... |
Human | E. coli |
Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. | |||
TMPY-04934 |
Serpin A3n Protein, Rat, Recombinant (His)
serine (or cysteine) peptidase inhibitor, clade A, ... |
Rat | HEK293 Cells |
Serpina3n may represent a circulating biomarker of muscle atrophy associated with GC and, broadly, a reflection of dynamic changes in muscle mass. Serpina3n blocks endogenous increases in the activity of select skeletal muscle resident proteases during injury or dystrophic disease, which stabilizes the sarcolemma leading to less myofiber degeneration and increased regeneration. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T32902 |
L-Serine-1-13C
L-(1-13C)Serine,L-(l-13C)Serine |
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L-Serine-1-13C is an amino acid. | |||
T74145 |
Deutarserine
|
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Deutarserine 是内源性 D-丝氨酸 (CTP 692) 的氘代物,用于成人精神分裂症的研究。 | |||
T69395 |
Nicotinamide-d4
|
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Nicotinamide-d4 is intended for use as an internal standard for the quantification of nicotinamide by GC- or LC-MS. Nicotinamide is an amide form of niacin, which is also known as vitamin B3, that can be biosynthesized in vivo or obtained through the diet. It is a precursor in the synthesis of the metabolic cofactor NAD+ and an inhibitor of sirtuin 1 (SIRT1; IC50 = <50 µM). Nicotinamide (10 µM) increases the activity of serine palmitoyltransferase (SPT) and the biosynthesis of ceramide, glucosyl... | |||
T36055 |
Nitisinone-13C6
Nitisinone-13C6 |
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Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F... |