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FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory effect.
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory effect.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 2,630 | 5日内发货 | |
25 mg | ¥ 14,700 | 8-10周 | |
50 mg | ¥ 19,200 | 8-10周 | |
100 mg | ¥ 25,500 | 8-10周 |
产品描述 | FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory effect. |
靶点活性 | Pancreatic elastase (porcine):100 nM, Neutrophil elastase (human):(ki)4.2 nM, Neutrophil elastase (human):83 nM, Neutrophil elastase (mouse):22 nM |
体外活性 | FK706 effectively inhibits the hydrolysis of bovine neck ligament elastin (2 mg/mL final concentration) by human neutrophil elastase (4 μg/mL final concentration) (IC50: 230 nM) [1]. FK706 blocks the release of inflammatory chemokines, suppresses the expression of IL-8 and MCP-1 mRNA, and suppresses NF-κB activation. FK706 may directly block human lung fibroblasts activation of NF-κB, preventing the expression of inflammatory chemokines during cigarette smoke-induced lung inflammation [2]. |
体内活性 | FK706 (10-100 mg/kg; subcutaneous injection; for 1-6 hours; male C57BL mice) treatment obviously inhibits human neutrophil elastase (20 μg/paw)-induced paw edema in mice. It shows a dose-dependent manner (47% inhibition at a dose of 100 mg/kg) [1]. |
分子量 | 593.556 |
分子式 | C26H33F3N4NaO7 |
CAS No. | 144055-55-0 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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