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(+)-SHIN1 ((+)-RZ-2994) 是 SHIN1 的活性 (+) 对映体。SHIN1 是人丝氨酸羟甲基转移酶1和2 (SHMT1/2) 抑制剂。
(+)-SHIN1 ((+)-RZ-2994) 是 SHIN1 的活性 (+) 对映体。SHIN1 是人丝氨酸羟甲基转移酶1和2 (SHMT1/2) 抑制剂。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 11,200 | 6-8周 | |
50 mg | ¥ 19,200 | 6-8周 |
产品描述 | (+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1 [1]. SHIN1 is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor. |
体外活性 | (+)-SHIN1 ((+)-RZ-2994) is potent against cytosolic SHMT1 with growth-blocking IC50s for of less than 50 nM and 870 nM in SHMT2 deletion cells and HCT-116 cells, respectively [1]. |
别名 | (+)-RZ-2994 |
分子量 | 400.47 |
分子式 | C24H24N4O2 |
CAS No. | 2443966-90-1 |
密度 | 1.32 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 100 mg/mL (249.71 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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