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TMPY-04644
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PDGFB Protein, Human, Recombinant (His)
platelet-derived growth factor beta polypeptide,SSV,c-sis,SI...
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Human
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P. pastoris (Yeast)
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Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted... |
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TMPY-02869
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MMP-12 Protein, Human, Recombinant (catalytic domain)
HME,ME,MMP-12,MME,matrix metallopeptidase 12
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Human
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E. coli
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Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ... |
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TMPK-01048
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Aggrecan Protein, Human, Recombinant (His)
CSPG1,MSK16,AGC1,ACAN
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Human
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HEK293 Cells
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Aggrecan is a large proteoglycan that forms giant hydrated aggregates with hyaluronan in the extracellular matrix (ECM). The extraordinary resistance of these aggregates to compression explains their abundance in articular cartilage of joints where they ensure adequate load-bearing. In the brain, they provide mechanical buffering and contribute to formation of perineuronal nets, which regulate synaptic plasticity. Aggrecan is also present in cardiac jelly, developing heart valves, and blood vess... |
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TMPY-00410
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EPHX2 Protein, Human, Recombinant (His)
SEH,CEH,epoxide hydrolase 2, cytoplasmic
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Human
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Baculovirus Insect Cells
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Genetic variation in EPHX2 was significantly associated with risk of incident CHD in Caucasians, implicating EPHX2 as a potential cardiovascular disease-susceptibility gene. Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene had been implicated in susceptibility to cardiovascular disease, including stroke. The human EPHX2 mutations may in part explain the genetic variability in sensitivity to ischemic brain injury and stroke outcome. Epoxide hydrolase is involved in metabolism of vas... |
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TMPY-00319
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GIP Protein, Human, Recombinant (hFc)
gastric inhibitory polypeptide,GIP
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Human
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HEK293 Cells
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Glucose-dependent insulinotropic polypeptide (GIP) is an incretin that plays an important role in fat accumulation. GIP is involved in fat accumulation and insulin resistance with aging. Glucose-dependent insulinotropic polypeptide (GIP) is an intestinal hormone with a broad range of physiological actions. Elevated concentrations of the incretin hormone GIP are found in patients with atherosclerotic cardiovascular disease, while GIP treatment attenuates atherosclerotic plaque inflammation in mi... |
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TMPK-01221
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APLN Protein, Mouse, Recombinant (hFc & Avi), Biotinylated
APEL,APJ endogenous ligand,Apelin
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Mouse
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HEK293 Cells
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Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. |
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TMPJ-01300
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PDCD10 Protein, Human, Recombinant
TFAR15,Programmed Cell Death Protein 10,PDCD10,TF-1 Cell Apo...
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Human
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E. coli
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Programmed Cell Death Protein 10 (PDCD10) belongs to the PDCD10 family. PDCD10 exists as a homodimer and is widely expressed. PDCD10 can increase mitogen-activated protein kinase activity and MST4 activity. PDCD10 is required for normal cardiovascular development and normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. Defects in PDCD10 are the cause of cerebral cavernous malformations type 3. |
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TMPY-04877
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PDGFB Protein, Mouse, Recombinant (His)
platelet-derived growth factor β polypeptide,血小板源生长因子,Sis,pl...
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Mouse
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P. pastoris (Yeast)
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Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted... |
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TMPH-02854
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Jagged 1 Protein, Mouse, Recombinant (His & Myc & SUMO)
Protein jagged-1,Jag1
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Mouse
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E. coli
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Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. May regulate fibroblast growth factor-induced angiogenesis. Jagged 1 Protein, Mouse, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 53.6 ... |
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TMPK-01236
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APLN Protein, Human, Recombinant (hFc)
APJ endogenous ligand,Apelin,APEL
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Human
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HEK293 Cells
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Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. Additionally, due to the widespread distribution of the CVD, more effective therapeutic strategies need to be developed to overcome the related complications. APLN Protein, Human, Recombinant (hFc) is expressed in HE... |
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TMPY-05076
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PDGFB Protein, Canine, Recombinant (His)
platelet-derived growth factor beta polypeptide,platelet-der...
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Canine
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P. pastoris (Yeast)
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Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Canine, Recombinant (His) is expressed in yeast with His tag. The predicte... |
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TMPY-02395
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PDGFB Protein, Cynomolgus, Recombinant (mFc)
血小板源生长因子,platelet-derived growth factor beta polypeptide,pla...
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Cynomolgus
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HEK293 Cells
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Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Cynomolgus, Recombinant (mFc) is expressed in HEK293 mammalian cells with ... |
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TMPK-00299
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ANGPTL2 Protein, Human, Recombinant (His & Avi), Biotinylated
MGC8889,ANGRP2,angiopoietin-like 2,ANGPTL2,HARP,ARP2
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Human
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HEK293 Cells
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Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers. ANGPTL2 Protein, ... |
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TMPK-01222
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APLN Protein, Mouse, Recombinant (hFc)
APJ endogenous ligand,APEL,Apelin
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Mouse
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HEK293 Cells
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Macrophages play key roles during cardiovascular diseases (CVD) and their related complications.Apelin (APLN) is a key molecule, whose roles during CVD have been documented previously. Therefore, it has been hypothesized that APLN may perform its roles via modulation of macrophages. Additionally, due to the widespread distribution of the CVD, more effective therapeutic strategies need to be developed to overcome the related complications. APLN Protein, Mouse, Recombinant (hFc) is expressed in HE... |
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TMPK-00298
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ANGPTL2 Protein, Human, Recombinant (His & Avi)
ANGRP2,ANGPTL2,angiopoietin-like 2,HARP,MGC8889,ARP2
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Human
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HEK293 Cells
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Angiopoietin-like 2 (ANGPTL2) is a proinflammatory protein belonging to the angiopoietin-like family. ANGPTL2 is secreted and detected in the systemic circulation. Different observational clinical studies reported that circulating levels of ANGPTL2 increase significantly in various chronic inflammatory diseases and showed associations between ANGPTL2 levels and diagnosis and/or prognosis of cardiovascular diseases, diabetes, chronic kidney disease, and various types of cancers. ANGPTL2 Protein, ... |
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TMPY-05077
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PDGFB Protein, Rhesus, Recombinant (His)
platelet-derived growth factor β polypeptide,platelet-derive...
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Rhesus
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P. pastoris (Yeast)
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Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionality. Interestingly, this effect exerted by PDGFB was also observed in the presence of DAPT. So PDGFB is able to improve tumor vascularity and allows the anticancer action of DAPT in the tumor. PDGFB Protein, Rhesus, Recombinant (His) is expressed in yeast with His tag. The predicte... |
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TMPJ-00931
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Serpin A4 Protein, Human, Recombinant (His)
Kallistatin,Peptidase Inhibitor 4,KST,Kallikrein Inhibitor,S...
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Human
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HEK293 Cells
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Serpin Peptidase Inhibitor, Clade A (α-1 Antiproteinase, Antitrypsin), Member 4 (Serpin A4) is a member of the Serpin family. Serpin A4 exists as a monomer and some homodimers. Serpin A4 is expressed by the liver and secreted in plasma. Serpin A4 is a regulator of vascular homeostasis capable of controlling a wide spectrum of biological actions in the cardiovascular and renal systems. It can inhibit intracellular reactive oxygen species formation in cultured cardiac and renal cells. In addition,... |
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TMPJ-01414
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GDF-15 Protein, Mouse, Recombinant (His & Flag)
Growth Differentiation Factor 15, Macrophage inhibitory cyto...
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Mouse
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HEK293 Cells
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Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be secreted by a wide variety of cell types in response to a broad range of stressors. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. GDF15 was shown to inhibit proliferation of primitive hematopoietic progenito... |
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TMPY-00286
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Neuropeptide Y Protein, Human, Recombinant (hFc)
PYY4,neuropeptide Y
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Human
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HEK293 Cells
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NPY (Neuropeptide Y) is a Protein Coding gene. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. NPY is a neuromodulator that is widely expressed throughout the central nervous system (CNS) and is consecrated with classic neurotransmitters including GABA and glutamate. NPY/Agouti-related protein (AgRP) ne... |
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TMPJ-00878
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NPR3 Protein, Human, Recombinant (hFc)
ANPRC,ANPR-C,C5orf23,NPR-C,NPRC,NPR3,ANP-C
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Human
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HEK293 Cells
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Atrial Natriuretic Peptide Receptor-3 (NPR3), also known as NPRC or ANPR-C, is one of the three natriuretic peptide receptors, is a type I transmembrane glycoprotein. The natriuretic system is key to the maintenance of vascular tone and cardiovascular homeostasis. Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for N... |
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TMPY-02963
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Calcineurin A/PPP3CA Protein, Human, Recombinant (His)
CALNA1,CNA1,PPP2B,CALNA,CCN1,protein phosphatase 3, catalyti...
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Human
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Baculovirus Insect Cells
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PPP3CA, also known as protein phosphatase 2B, is a member of the PPP phosphatase family, PP-2B subfamily. It is the alpha catalytic subunit of protein phosphatase 2B (PP2B). PP2B is a holoenzyme that is comprised of a catalytic subunit associated with regulatory subunits. It is a calcium regulated enzyme that is activated by calmodulin and participates in the signaling cascades involved in development of the nervous, cardiovascular, and musculoskeletal systems. PPP3CA activates the T cells of th... |
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TMPJ-00817
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HO-1 Protein, Human, Recombinant
HO,HMOX1,HO-1,Heme Oxygenase 1,HO1
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Human
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E. coli
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Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy me... |
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TMPJ-00362
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MMP-2 Protein, Human, Recombinant (His)
72 kDa Gelatinase,TBE-1,Gelatinase A,Matrix Metalloproteinas...
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Human
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HEK293 Cells
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72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis and tissue remodeling, as well as pathologic... |
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TMPJ-00920
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CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His)
TNFSF5,Tumor necrosis factor ligand superfamily member 5,CD4...
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Mouse
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HEK293 Cells
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CD40 Ligand, also known as TNFSF5, CD154, is a type II transmembrane glycoprotein member of the TNF superfamily. Mature mouse CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and a 214 aa extracellular region. CD40 Ligand is expressed as a homotrimer on platelets and activated T cells and B cells. It is upregulated following stimulation of basophils, eosinophils, fibroblasts, mast cells, monocytes, natural killer cells, vascular endothelial cells, and sm... |
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TMPY-05252
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Myeloperoxidase/MPO Protein, Human, Recombinant (His)
myeloperoxidase
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Human
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HEK293 Cells
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MPO (myeloperoxidase) is a peroxidase enzyme secreted by activated leukocytes that plays a pathogenic role in cardiovascular disease, mainly by initiating endothelial dysfunction. Myeloperoxidase (MPO) is an important enzyme, which is one of the components of the antibacterial system in neutrophils and monocytes. MPO participates in the inflammatory response in multiple locations in the body, including the mammary glands. Myeloperoxidase (MPO), a specific polymorphonuclear leukocyte enzyme, has ... |
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TMPY-04562
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GRK2 Protein, Human, Recombinant (His & GST)
β,adrenergic, beta, receptor kinase 1
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Human
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Baculovirus Insect Cells
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G-protein coupled receptor kinase 2 (GRK2), also referred as Adrenergic, beta, receptor kinase 1 (ADRBK1), is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction cascades. GRK2 can phosphorylate a growing number of non-GPCR substrates and associate with a variety of proteins related to signal transduction, thus suggesting that this kinase could also have diverse 'effector' functions. GRK2 has been repor... |
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TMPY-02051
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FABP2 Protein, Human, Recombinant (His)
MGC133132,fatty acid binding protein 2,FABPI,I-FABP
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Human
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E. coli
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Fatty acid binding protein (FABP) is one of the intracellular proteins, with a low molecular weight of approximately 15 kDa, that plays important roles in the transportation and metabolism of long-chain fatty acids. FABP family proteins could be used as tissue specific injury marker based on the following characteristics of FABP. The intestinal fatty acid binding protein (I-FABP), or fatty acid-binding protein 2 (FABP2), an intracellular protein expressed only in the intestine, involved in the a... |
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TMPJ-00100
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Artemin Protein, Human, Recombinant
ARTN,Artemin,EVN,Enovin,Neublastin
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Human
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E. coli
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Human Artemin is a GDNF family ligand that is distantly related to the TGF-β superfamily of molecules. It is synthesized as a preproprotein, and contains a variable length pre-, or signal sequence, plus a 68 amino acid (aa) proregion and a 113 aa mature segment. Following synthesis and proteolytic processing, mature ARTN is secreted as a presumably glycosylated, 28 kDa disulfide-linked homodimer that contains three intrachain disulfide bonds and the typical TGF-β signature cysteine-knot motif. I... |
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TMPY-02220
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HRAS Protein, Human, Recombinant (His)
HAMSV,Harvey rat sarcoma viral oncogene homolog,C-H-RAS,C-HA...
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Human
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Baculovirus Insect Cells
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HRas, also known as HRAS, belongs to the small GTPase superfamily, Ras family, and is widely expressed. It functions in signal transduction pathways. HRas can bind GTP and GDP, and they have intrinsic GTPase activity. It undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Defects in HRAS are the cause of faciocutaneoskeletal syndrome (FCSS). FCSS is a rare condition characterized by prenatally increase... |
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