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Search Results for " non-small "

Targets Recommended: VEGFR

182

抑制剂 & 化合物

28

天然产物

7

化合物库

25

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name
L9410	共价抑制剂库		1920 compounds
	1920 种小分子的独特集合，包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子，如氯乙酰基，2-氯丙酰基，丙烯酰基，1-丙-2-炔基，1-丁-2-炔基，酮羰基，二硫键等，可以用于共价抑制剂药物研发；
L2170	肿瘤免疫治疗小分子化合物库		449 compounds
	449 种靶向肿瘤免疫治疗靶点的小分子，可用于高通量和高内涵筛选，是研究肿瘤免疫治疗的有力工具；
L4700	免疫/炎症分子化合物库		4720 compounds
	4720 种具有抗炎症活性的化合物的特有集合，可用于高通量筛选和高内涵筛选；
L2190	抗肺癌化合物库		1702 compounds
	1702 种与肺癌相关的化合物，可以用于抗肺癌药物研发和药理研究；
L7600	趋化因子抑制剂库		59 compounds
	59 种趋化因子或其受体抑制剂的独特集合，可用于高通量筛选和高内涵筛选；
L8720	细胞焦亡化合物库		1066 compounds
	1066 种细胞焦亡相关的化合物，可以用于细胞焦亡相关研究。
DO1200	药物靶点库		53200 compounds
	数量多，含53200种小分子化合物，是高通量筛选的有力工具；

化合物库

共价抑制剂库

Cat.No: L9410

Compounds: 1920

肿瘤免疫治疗小分子化合物库

Cat.No: L2170

Compounds: 449

免疫/炎症分子化合物库

Cat.No: L4700

Compounds: 4720

抗肺癌化合物库

Cat.No: L2190

Compounds: 1702

趋化因子抑制剂库

Cat.No: L7600

Compounds: 59

细胞焦亡化合物库

Cat.No: L8720

Compounds: 1066

药物靶点库

Cat.No: DO1200

Compounds: 53200

Cat. No.	Product Name	Target	Signaling Pathways
T9929	Ramucirumab	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Ramucirumab 是一种人 VEGFR-2 拮抗剂，具有抗实体瘤活性。它是人源化单克隆抗体，能够与 VEGFR-2 结合，阻碍 VEGFR 配体 VEGF-A，VEGF-C 和 VEGF-D 结合。
T10777	CG347B	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CG347B 是一种选择性HDAC6抑制剂。
T21588	Olomoucine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Olomoucine 是 Cdk2/cyclin A、Cdc2/CyclinB、CDK2/CyclinE、CDK5/p35 和 ERK1/p44 MAP 激酶的 ATP 竞争性抑制剂，IC50 分别为 7、7、7、3 和 25 µM。 Olomoucine 调节细胞周期并表现出抗黑色素肿瘤活性。
T39275	Befotertinib D-0316,Befotertinib	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Befotertinib (D-0316) 是一种 EGFR 酪氨酸激酶抑制剂，可用于 EGFR T790M 阳性非小细胞肺癌的研究。
T9865	Almonertinib mesylate	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Almonertinib mesylate 是一种不可逆的 EGFR 酪氨酸激酶抑制剂，对 EGFR 敏感突变和 T790M 耐药突变具有高选择性。它可用于非小细胞肺癌研究。
T8756	KRAS inhibitor-9 DUN09716	Apoptosis; Ras	Apoptosis; GPCR/G Protein; MAPK
	KRAS inhibitor-9 (DUN09716) 是一种 KRAS 抑制剂，阻止 GTP-KRAS 的形成和 KRAS 下游激活。它以中等的结合亲和力与 KRAS G12D、KRAS G12C 和 KRAS Q61H 蛋白结合，选择性抑制具有 KRAS 突变的 NSC-LC 细胞的增殖。它可导致 G2/M 细胞周期停滞并诱导凋亡。
T60076	Oritinib SH-1028	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Oritinib (SH-1028) 是一种 EGFR 抑制剂，对 EGFR (wt)、EGFR (L858R)、EGFR (L861Q)、EGFR (L858R/T790M)、EGFR (d746-750) 的 IC50 分别为 18、0.7、4、0.1、1.4 和 0.89 nM , EGFR (d746-750/T790M), 分别。奥瑞替尼可用于治疗非小细胞肺癌的研究。
T5462	Almonertinib HS-10296,阿美替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Almonertinib (HS-10296) 是EGFR 激活突变抑制剂和EGFR T790M 耐受突变抑制剂，对 EGFR 致敏和 T790M 耐药突变具有高选择性，用于非小细胞肺癌的研究。它对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性，对野生型的抑制作用较弱。
T2325	Neratinib HKI-272,来那替尼	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Neratinib (HKI-272) 是一种酪氨酸激酶受体抑制剂，可以抑制 HER2 和 EGFR (IC50=59/92 nM)，具有不可逆性和口服活性。Neratinib 具有抗肿瘤活性，可以用于治疗乳腺癌。
T0373	Erlotinib OSI-744,NSC 718781,CP358774,埃罗替尼,R1415	EGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Erlotinib (CP358774) 是一种 EGFR 一代抑制剂，抑制 EGFR 19 Del 和 L858R 突变。Erlotinib 具有抗肿瘤活性，用于治疗 EGFR 突变的非小细胞肺癌。Erlotinib 用药会产生 EGFR C797S 耐药突变。
T8656	CAY10404 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T	Apoptosis; Akt; COX	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling
	CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂，可诱导 NSC-LC 细胞凋亡，具有镇痛、抗炎和抗癌活性。
T6804	Chetomin Chaetomin,NSC289491,BRN0077366	Apoptosis; HSP; HIF	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	Chetomin (BRN0077366) 是球毛壳菌的活性成分，是一种无毒的非小细胞肺癌干细胞靶向分子。它是一种热休克蛋白90/缺氧诱导因子1α 途径的抑制剂。
T5675	Almonertinib hydrochloride HS-10296 hydrochloride,盐酸阿美替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Almonertinib hydrochloride (HS-10296 hydrochloride) 是一种 EGFR 激活突变和 T790M 耐药突变的小分子抑制剂，用于非小细胞肺癌的研究，对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性，对野生型的抑制作用较弱。
T15390	Glufosfamide D 19575,Glucosylifosfamide mustard	Others	Others
	Glufosfamide 是一种新型噁唑磷胺化合物，具有抗癌活性，可用于研究晚期非小细胞肺癌。
T36404L	PRLX-93936 HCL PRLX-93936 hcl(903499-49-0 Free base)	Ferroptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	PRLX-93936 HCL 是 erastin 的类似物，并显示出与顺铂对非小细胞肺癌 (NSCLC) 细胞的协同作用。
T1758	ABT-751 E7010	Microtubule Associated; Autophagy	Autophagy; Cytoskeletal Signaling
	ABT-751 (E7010) 是一种新型的生物相容性的微管蛋白结合剂，用于治疗肺癌、非小细胞肺癌和非小细胞肺癌。它是磺胺类抗有丝分裂抑制剂，对神经母细胞瘤细胞株和非神经母细胞瘤细胞株的IC50分别为1.5 和 3.4 μM。
T30087	Antroquinonol	Reactive Oxygen Species; Nrf2	Immunology/Inflammation; Metabolism; NF-κB
	Antroquinonol 是一种来源于 Antrodia camphorata 的泛醌衍生物，具有抗炎和抗癌活性。Antroquinonol 通过增强 Nrf2 信号通路降低氧化应激，抑制局灶节段性肾小球硬化小鼠的炎症和硬化。Antroquinonol 具有治疗非小细胞肺癌的潜力，可用于结肠癌的研究。
T0373L	Erlotinib hydrochloride 盐酸埃罗替尼,OSI-744,NSC 718781,Erlotinib HCl,CP-358774	EGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Erlotinib hydrochloride (NSC 718781) 抑制EGFR 激酶的IC50为 2 nM，用于治疗非小细胞肺癌。
T9673	RET-IN-3	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	RET-IN-3 是一种具有选择性和高效性的 RETV804M 激酶抑制剂，具有潜在抗癌活性,可用于研究非小细胞肺癌。
T4354	KPT9274 KPT-9274,KPT 9274,PAK4-IN-1	NAMPT; PAK	Cytoskeletal Signaling; Metabolism
	KPT9274 (PAK4-IN-1) 是一种非竞争性的 PAK4 和 NAMPT 双重抑制剂（IC50= ~120 nM）。它是一种口服生物可利用的小分子。
T72043	SCFSkp2-IN-2	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	SCFSkp2-IN-2 是一种 Skp2抑制剂，其 KD 为 28.77 μM。AAA-237 诱导 NSCLC 细胞凋亡 (apoptosis)，显示出抗肿瘤活性。
T39764	KER047 ALK2-IN-4	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	KER047 (ALK2-IN-4) 是一种 ALK2 抑制剂，具有潜在的抗癌活性，可用于研究非小细胞肺癌。
T13564L2	AZ7550 trimesylate salt AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)	MLK	MAPK
	AZ7550 trimesylate salt (AZ7550 Mesylate) 是奥希替尼的活性代谢产物，AZ7550 trimesylate salt 抑制 IGF1R 活性，可用于研究非小细胞肺癌。
T24610	Pegamotecan Prothecan,PEG-camptothecin,PEG-beta-CPT	Topoisomerase	DNA Damage/DNA Repair
	Pegamotecan (PEG-camptothecin)是一种拓扑异构酶I(TOP1)抑制剂，具有抗癌活性，它可用于治疗食管癌、非小细胞肺癌和胰腺癌。
T23974	DDRI-18 DDRI18,DDRI 18	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DDRI-18 是一种调节 DNA 损伤反应的新型小分子抑制剂，具有增敏活性和抗癌活性，抑制非同源末端连接 (NHEJ) DNA 修复过程，增强抗癌 DNA 损伤化合物的细胞毒性作用。
T67934	MRT-2359	Others	Others
	MRT-2359 是一种有效的且可口服的 GSPT1 降解剂，具有抗肿瘤活性。MRT-2359 对耐药非小细胞肺癌 (NSCLC) 和小细胞肺癌 (SCLC) 细胞的生长具有抑制作用。MRT-2359 在 MYC 驱动的细胞系中表现出优先活性。
T9901A-002	Enoblituzumab MGA271,TJ-271	Others	Others
	Enoblituzumab 是一种人源化 IgG1κ 单克隆抗体，可以识别人 B7-H3 蛋白，可用于研究非小细胞肺癌（NSCLC）等实体肿瘤。
T40292	Opnurasib NVP-JDQ443,JDQ-443,Opnurasib	Ras	GPCR/G Protein; MAPK
	Opnurasib (JDQ-443) 是一种可口服且具有选择性和有效性的共价 KRAS G12C 抑制剂，具有抗肿瘤活性，可用于研究晚期非小细胞肺癌。
T35901	EGFR-IN-99 JBJ-03-142-02	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-99 (JBJ-03-142-02) 是一种 EGFR 和 HER2 Exon 20 插入突变抑制剂，具有抗增殖活性，可用于研究非小细胞肺癌 (NSCLC) 。
T76792	Sibrotuzumab BIBH 1,Anti-Human FAP Recombinant Antibody	Others	Others
	Sibrotuzumab (BIBH 1) 是一种靶向成纤维细胞激活蛋白 (FAP)的人源化 IgG1 单克隆抗体。Sibrotuzumab 可用于研究结直肠癌和非小细胞肺癌。
T78156	MC4033	Apoptosis; Histone Acetyltransferase	Apoptosis; Chromatin/Epigenetic
	MC4033 是一种选择性的赖氨酸乙酰转移酶8 (KAT8) 抑制剂（IC50：12.1 μM），具有抗癌作用，可诱导凋亡，可用于研究非小细胞肺癌。
T61016	EMI1	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EMI1 是 EGFR 三重突变体 (EGFR ex19del/T790M/C797S, EGFR L858R/T790M/C797S) 的有效抑制剂。EMI1 可用于 EGFR 突变相关的耐药型非小细胞肺癌 (NSCLC) 的研究。
T64028	Iruplinalkib WX-0593	ALK; ROS Kinase	Angiogenesis; Tyrosine Kinase/Adaptors
	Iruplinalkib (WX-0593) 是一种具有口服活性、选择性和高效性的 ALK 和 ROS1 酪氨酸激酶抑制剂，具有抗癌活性，可用于研究非小细胞肺癌。
T37042	SCH529074 SCH 529074	p53	Apoptosis
	SCH529074 是 p53 的选择性激活剂 (Ki = 1 μM)，可用于非小细胞肺癌的研究。 SCH529074 恢复突变 p53 功能并中断 HDM2 介导的野生型 p53 泛素化。
T74982	Akt3 degrader 1	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Akt3 degrader 1 是一种特异性 Akt3 降解剂，具有抗癌抗增殖活性，可抑制小鼠体内肿瘤的生长。Akt3 degrader 1 可用于研究非小细胞肺癌和胰腺癌。
T8986	ML198	Glucokinase	Metabolism
	ML198 是葡萄糖脑苷脂酶激活剂(EC50:0.4 μM)。它不会抑制该酶的作用，且能促进其易位至溶酶体，可用于研究戈谢病。
T35916	Simotinib AL-6802,SIM-6802	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Simotinib (AL-6802) 是一种具有选择性和口服生物活性的 EGFR 酪氨酸激酶抑制剂（ IC50 ：19.9 nM），具有抗肿瘤活性，可用于研究非小细胞性肺癌。
T13423L	(1S,2R)-2-PCCA (1S,2R)-2-PCCA（Iso-1609563-71-4）	GPR	Endocrinology/Hormones; GPCR/G Protein
	(1S,2R)-2-PCCA 是一种新型有效的小分子 GPR88 受体激动剂，非细胞体系下测的 EC50 值为 3 nM，细胞体系下测得 EC50 值为 603 nM。
T6084	Rabusertib LY2603618,IC-83	Chk; PDK; Autophagy	Autophagy; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling
	Rabusertib (IC-83) 是一种有效的选择性的Chk1抑制剂，IC50为 7 nM。它有潜在的化学增强活性，用于各种癌症和肿瘤治疗的试验。
T15019L	CUR61414 hydrochloride CUR61414 hydrochloride (334998-36-6 Free base)	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	CUR61414 hydrochloride 是属于氨基脯氨酸类化合物的小分子。CUR61414 hydrochloride 是一种细胞渗透性的 Hedgehog 信号通路抑制剂(IC50= 100-200 nM)，可选择性结合 Smoothened (Smo, Ki= 44 nM)。CUR61414 hydrochloride 可以诱导癌细胞凋亡 (apoptosis) 而不影响非癌症细胞。
T9460	iMDK	PI3K	PI3K/Akt/mTOR signaling
	iMDK 是PI3K 抑制剂，能够抑制生长因子MDK。它能够与 MEK 抑制剂协同抑制非小细胞肺癌，而不会伤害正常细胞和小鼠。
T36316	mTOR inhibitor-8 mTOR-IN-8	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	mTOR inhibitor-8 是一种有效的 mTOR 抑制剂和自噬诱导剂，具有抗病毒和抗肿瘤活性。mTOR inhibitor-8 抑制A549细胞的生长，可用于研究非小细胞肺癌。
T35391	Vibostolimab (anti-TIGIT) Vibostolimab (anti-TIGIT)	Others	Others
	Vibostolimab 是一种抗 T 细胞免疫蛋白和 ITIM 域的单克隆抗体。Vibostolimab 在体外实验中显示出抗肿瘤活性，可用于研究非小细胞肺癌 (NSCLC) 和黑色素瘤。
T1848	Dynasore Dynamin Inhibitor I	Dynamin; Virus Protease; Autophagy; HSV	Autophagy; Cytoskeletal Signaling; Microbiology/Virology
	Dynasore (Dynamin Inhibitor I) 是一种可渗透细胞的化学物质，可逆且非竞争性地抑制 dynamin 1/2 的 GTPase 活性。它还抑制线粒体动力蛋白 Drp1，对其他小 GTPase 没有影响。
T60039	KSQ-4279 USP1-IN-1	PARP; DUB	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Ubiquitination
	KSQ-4279 (USP1-IN-1)是 USP1 和 PARP 的抑制剂。KSQ-4279 具有抗癌活性，可用于研究非小细胞肺癌、骨肉瘤、卵巢癌、乳腺癌、胶质母细胞瘤、膀胱癌、子宫癌和胰腺癌。
T76796	Patritumab U3-1287,AMG-888	ERK; EGFR; Akt; HER	Angiogenesis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Patritumab（U3-1287）是抗 HER3 单克隆抗体，具有潜在的抗肿瘤活性，对 EGFR，HER2，HER3，ERK 和 AKT 的磷酸化有抑制作用和。Patritumab 促使细胞凋亡 (apoptosis)，抑制非小细胞肺癌的增殖。
T14997	Conteltinib SY-707,CT-707	FAK; PYK2; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Conteltinib (CT-707) 是一种靶向FAK、ALK 和 Pyk2 的酶抑制剂，具有抗肿瘤活性。Conteltinib 对 FAK 有明显的抑制作用，通过抑制 YAP 信号传导来克服肝细胞癌中缺氧介导的索拉非尼耐药性，可用于晚期 ALK 阳性非小细胞肺癌和淋巴癌。
T72784	OTUB1/USP8-IN-1	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	OTUB1/USP8-IN-1 是一种高效的 OTUB1/USP8 抑制剂，具有潜在的抗癌活性，对 OTUB1 和 USP8 的 IC50 值分别为 0.17 和 0.28 nM。OTUB1/USP8-IN-1 可用于研究非小细胞肺癌。
T2490	Osimertinib AZD-9291,Mereletinib,奥希替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Osimertinib (AZD-9291) 是一种 EGFR 三代抑制剂，抑制二代 EGFR 抑制剂产生的 T790M 耐药突变，具有不可逆性和口服活性。Osimertinib 具有抗肿瘤活性，用于治疗 EGFR 突变的非小细胞肺癌。
T76703	Tislelizumab VDT-482,BGB-A317	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Tislelizumab (BGB-A317) 是一种靶向人程序性死亡受体-1（PD-1）IgG4类单克隆抗体，具有抗肿瘤活性，抑制 Fcγ 受体与巨噬细胞的结合，可用于研究晚期鳞状非小细胞肺癌。

化合物

Cat.No: T9929

Target: VEGFR

Cat.No: T10777

Target: HDAC

Cat.No: T21588

Target: ERK, CDK

Cat.No: T39275

Synonym: D-0316,Befotertinib

Target: EGFR

Almonertinib mesylate

Cat.No: T9865

Target: EGFR

KRAS inhibitor-9

Cat.No: T8756

Synonym: DUN09716

Target: Apoptosis, Ras

Cat.No: T60076

Synonym: SH-1028

Target: EGFR

Cat.No: T5462

Synonym: HS-10296,阿美替尼

Target: EGFR

Cat.No: T2325

Synonym: HKI-272,来那替尼

Target: EGFR, HER

Cat.No: T0373

Synonym: OSI-744,NSC 718781,CP358774,埃罗替尼,R1415

Target: EGFR, Autophagy

Cat.No: T8656

Synonym: 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T

Target: Apoptosis, Akt, COX

Cat.No: T6804

Synonym: Chaetomin,NSC289491,BRN0077366

Target: Apoptosis, HSP, HIF

Almonertinib hydrochloride

Cat.No: T5675

Synonym: HS-10296 hydrochloride,盐酸阿美替尼

Target: EGFR

Cat.No: T15390

Synonym: D 19575,Glucosylifosfamide mustard

Target: Others

Cat.No: T36404L

Synonym: PRLX-93936 hcl(903499-49-0 Free base)

Target: Ferroptosis, Reactive Oxygen Species

Cat.No: T1758

Synonym: E7010

Target: Microtubule Associated, Autophagy

Cat.No: T30087

Target: Reactive Oxygen Species, Nrf2

Erlotinib hydrochloride

Cat.No: T0373L

Synonym: 盐酸埃罗替尼,OSI-744,NSC 718781,Erlotinib HCl,CP-358774

Target: EGFR, Autophagy

Cat.No: T9673

Target: c-RET

Cat.No: T4354

Synonym: KPT-9274,KPT 9274,PAK4-IN-1

Target: NAMPT, PAK

Cat.No: T72043

Target: Apoptosis, E1/E2/E3 Enzyme

Cat.No: T39764

Synonym: ALK2-IN-4

Target: ALK

AZ7550 trimesylate salt

Cat.No: T13564L2

Synonym: AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)

Target: MLK

Cat.No: T24610

Synonym: Prothecan,PEG-camptothecin,PEG-beta-CPT

Target: Topoisomerase

Cat.No: T23974

Synonym: DDRI18,DDRI 18

Target: DNA/RNA Synthesis

Cat.No: T67934

Target: Others

Cat.No: T9901A-002

Synonym: MGA271,TJ-271

Target: Others

Cat.No: T40292

Synonym: NVP-JDQ443,JDQ-443,Opnurasib

Target: Ras

Cat.No: T35901

Synonym: JBJ-03-142-02

Target: EGFR, HER

Cat.No: T76792

Synonym: BIBH 1,Anti-Human FAP Recombinant Antibody

Target: Others

Cat.No: T78156

Target: Apoptosis, Histone Acetyltransferase

Cat.No: T61016

Target: EGFR

Cat.No: T64028

Synonym: WX-0593

Target: ALK, ROS Kinase

Cat.No: T37042

Synonym: SCH 529074

Target: p53

Akt3 degrader 1

Cat.No: T74982

Target: Akt

Cat.No: T8986

Target: Glucokinase

Cat.No: T35916

Synonym: AL-6802,SIM-6802

Target: EGFR

Cat.No: T13423L

Synonym: (1S,2R)-2-PCCA（Iso-1609563-71-4）

Target: GPR

Cat.No: T6084

Synonym: LY2603618,IC-83

Target: Chk, PDK, Autophagy

CUR61414 hydrochloride

Cat.No: T15019L

Synonym: CUR61414 hydrochloride (334998-36-6 Free base)

Target: Hedgehog/Smoothened

Cat.No: T9460

Target: PI3K

mTOR inhibitor-8

Cat.No: T36316

Synonym: mTOR-IN-8

Target: mTOR, Autophagy

Vibostolimab (anti-TIGIT)

Cat.No: T35391

Synonym: Vibostolimab (anti-TIGIT)

Target: Others

Cat.No: T1848

Synonym: Dynamin Inhibitor I

Target: Dynamin, Virus Protease, Autophagy, HSV

Cat.No: T60039

Synonym: USP1-IN-1

Target: PARP, DUB

Cat.No: T76796

Synonym: U3-1287,AMG-888

Target: ERK, EGFR, Akt, HER

Cat.No: T14997

Synonym: SY-707,CT-707

Target: FAK, PYK2, ALK

OTUB1/USP8-IN-1

Cat.No: T72784

Target: DUB

Cat.No: T2490

Synonym: AZD-9291,Mereletinib,奥希替尼

Target: EGFR

Cat.No: T76703

Synonym: VDT-482,BGB-A317

Target: PD-1/PD-L1

Cat. No.	Product Name	Target	Signaling Pathways
T4903	Heptadecanoic acid	Others; Endogenous Metabolite	Metabolism; Others
	Heptadecanoic acid 是奇链饱和脂肪酸，与一些疾病（如冠心病、糖尿病前期和 2 型糖尿病以及多发性硬化症）有关。
T2870	Matrine Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy; Ferroptosis; Opioid Receptor; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Matrine (Vegard) 是一种从槐属植物中分离出来的生物碱，可作为一种κ阿片受体激动剂，有抗肿瘤活性。
T7849	Norspermine	Others	Others
	Norspermine 是一种多胺类似物，用于治疗非小细胞肺癌和乳腺癌。
T25192	Butyrolactone I Olomoucin,丁酸内酯I	CDK	Cell Cycle/Checkpoint
	Butyrolactone I (Olomoucin) 是 CDK 和 cdc2 激酶家族的 ATP 竞争性抑制剂。 Butyrolactone I 在非小细胞肺、小细胞肺和前列腺癌细胞系中显示出抗肿瘤作用。
TN5254	Wighteone Erythrinin B,6-Isopentenylgenistein	Antifungal	Microbiology/Virology
	Wighteone (Erythrinin B) 是一种从 Genista ephedroides 中提取出来的小分子化合物，具有潜在的抗真菌和抗癌活性，对 EGFR L858R/T790M 突变非小细胞肺癌具有抗肿瘤作用。。
TQ0275	LysoPC(14:0/0:0)	Others; Endogenous Metabolite	Metabolism; Others
	LysoPC(14:0/0:0) 是一种溶血磷脂，它是单甘油磷脂，其中甘油取代位点被磷酸胆碱占据。LysoPC(14:0/0:0) 有抗痉挛作用。
T5590	2-(4-Methoxyphenyl)acetic acid 4-Methoxyphenylacetic acid,对甲氧基苯乙酸	Others; Endogenous Metabolite	Metabolism; Others
	2-(4-Methoxyphenyl)acetic acid 是血浆代谢物，具有高度敏感性和特异性，能够作为区分非小细胞癌患者和健康对照组之间的生物指标。
TN1721	Gypenoside L	ERK; p38 MAPK; Calcium Channel; NF-κB; ROS	Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Metabolism; NF-κB
	Gypenoside L 是存在于绞股蓝中的一种皂苷，可增加 SA-β-半乳糖苷酶活性，促进衰老相关分泌细胞因子的产生。它还可以激活p38和ERK MAPK 通路和NF-κB 通路以诱导衰老，具有抗肿瘤和抗炎活性。
TJO2729	L-Alanine L-2-Aminopropionic acid,alanine,丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	L-Alanine (L-2-Aminopropionic acid) 是一种非必需氨基酸，可参与糖和酸的代谢，为肌肉组织、大脑和中枢神经系统提供能量，并增强免疫力。
T1181	Gefitinib ZD1839,吉非替尼	EGFR; Tyrosine Kinases; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Gefitinib (ZD1839) 是一种 EGFR 一代抑制剂，具有口服活性，抑制 EGFR 19 Del 和 L858R 突变。Gefitinib 具有抗肿瘤活性，用于治疗 EGFR 突变的非小细胞肺癌。Gefitinib 用药会产生 EGFR C797S 耐药突变。
T3051	Theaflavin-3-gallate 茶黄素-3-没食子酸酯,茶黄素 3-没食子酸酯,茶黄素 -3-没食子酸,Theaflavine-3-Gallate	Others	Others
	Theaflavin-3-gallate (Theaflavine-3-Gallate) 是红茶茶黄素单体，是红茶生物学上重要的活性成分，对健康有益。它以时间和浓度依赖性方式与还原型谷胱甘肽直接反应。它充当促氧化剂并在癌细胞中诱导氧化应激。
TN1516	Cnidicin 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮	NOS; NO Synthase	Immunology/Inflammation
	Cnidicin 是一种香豆素，对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。
T4723	D-Tagatose 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos	Others; Endogenous Metabolite	Metabolism; Others
	D-Tagatose (D-(-)-Tagatose) 是自然界中发现的一种罕见的单糖，具有益生元特性。它是研究II 型糖尿病的潜在抗糖尿病药物，也是帮助提升结肠有益细菌、预防结肠癌和抑制胆固醇的益生元。它是蔗糖的替代品，也是口香糖、果汁和饮料等食品中的低热量甜味剂。
T2163	Dihydrocapsaicin CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide	Others; TRP/TRPV Channel	Membrane transporter/Ion channel; Others
	Dihydrocapsaicin (CCRIS1589) 是一种天然来源的辣椒素，是TRPV1的选择性激动剂，同时可以增加 p-Akt 水平。它可以增强低温诱导的神经保护。
TN3972	Epimedokoreanin B	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Epimedokoreanin B （EKB）是一种从韩国淫羊藿中分离出的异戊烯化类黄酮，在人非小细胞肺癌（NSCLC）A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性，可有清除 DPPH 自由基的活性，能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -（羧甲基）赖氨酸（CML）和 N (Ï) -（羧甲基）精氨酸（CMA）的形成，可通过抑制高级糖化终产物（AGEs）预防糖尿病的临床并发症。
TN4177	Gypenoside LI	Others	Others
	Gypenoside LI possesses non-small cell lung carcinoma A549 cell inhibitory activity.
TN3355	Agatharesinol acetonide	Antifection	Microbiology/Virology
	Agatharesinol acetonide shows anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM).
TN1642	Ferruginol 铁锈罗汉柏醇	BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells.
TN4355	Jolkinol A	Others	Others
	Jolkinol A can inhibit both MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM.
TN5440	Catechin-7-O-xyloside Catechin 7-O-β-D-xylopyranoside	Others	Others
	Catechin-7-O-xyloside（C7Ox）具有抗癌活性，它通过内质网应激和线粒体功能障碍诱导人非小细胞肺癌H1299细胞凋亡。
TN4166	Griffipavixanthone	ERK; Raf; ROS; MEK; Caspase	Apoptosis; Immunology/Inflammation; MAPK; Proteases/Proteasome
	Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. It can inhibit tumor metastasis
T11009	Destruxin B	Others	Others
	Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces apoptosis of human non-small cell lung cancer cells through the Bcl-2 family-dependent mitochond
TN6062	1,3,9-Trimethyluric acid
	1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 1,3,9-Trimethyluric a
T81132	Soladulcoside A	Others	Others
	Soladulcoside A，一种甾体糖苷及抗肿瘤剂，源自龙葵全株。该化合物可抑制A549细胞，并展示对治疗非小细胞肺癌(NSCLC)等癌症的潜在应用。
TN4774	Physalin A	ERK; BCL; p38 MAPK; NF-κB; Androgen Receptor; ROS; JAK; JNK; STAT; p53; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; JAK/STAT signaling; MAPK; NF-κB; Stem Cells
	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor ex
T82032	Isoglobotriaose Gala-3Galb-4Glc
	Isoglobotriaose (Gala-3Galb-4Glc)是哺乳动物组织中的一种糖鞘脂，属于球状三脂糖的类似物。其神经节苷脂衍生物isoglobotriaosylceramide特定分布于小肠非上皮细胞的残基中，而globotriaosylceramide则在两种细胞隔室中都有分布。
TN7505	Thujopsene NSC 44707	Others	Others
	Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 µg/ml and Ki of 0.8 µM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 µg/ml. It also suppresses antigen-induced β-hexosaminidase release in IgE-se...
T81201	Sartorypyrone B
	Sartorypyrone B为Chevalone C的2β-乙酰氧基衍生物，由海绵源真菌Neosartorya tsunodae(KUFC 9213)的培养物中乙酸乙酯提取得到。该化合物对MCF-7、NCI-H460和A375-C5细胞系展示出较强的生长抑制活性，GI50s值分别为17.8、20.5和25.0 μM，显示其在乳腺癌、非小细胞肺癌和黑色素瘤研究中的应用潜力。

天然产物

Heptadecanoic acid

Cat.No: T4903

Target: Others, Endogenous Metabolite

Cat.No: T2870

Synonym: Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine

Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy

Cat.No: T7849

Target: Others

Butyrolactone I

Cat.No: T25192

Synonym: Olomoucin,丁酸内酯I

Target: CDK

Cat.No: TN5254

Synonym: Erythrinin B,6-Isopentenylgenistein

Target: Antifungal

LysoPC(14:0/0:0)

Cat.No: TQ0275

Target: Others, Endogenous Metabolite

2-(4-Methoxyphenyl)acetic acid

Cat.No: T5590

Synonym: 4-Methoxyphenylacetic acid,对甲氧基苯乙酸

Target: Others, Endogenous Metabolite

Cat.No: TN1721

Target: ERK, p38 MAPK, Calcium Channel, NF-κB, ROS

Cat.No: TJO2729

Synonym: L-2-Aminopropionic acid,alanine,丙氨酸

Target: Others, Endogenous Metabolite

Cat.No: T1181

Synonym: ZD1839,吉非替尼

Target: EGFR, Tyrosine Kinases, Autophagy

Theaflavin-3-gallate

Cat.No: T3051

Synonym: 茶黄素-3-没食子酸酯,茶黄素 3-没食子酸酯,茶黄素 -3-没食子酸,Theaflavine-3-Gallate

Target: Others

Cat.No: TN1516

Synonym: 蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮

Target: NOS, NO Synthase

Cat.No: T4723

Synonym: 塔格糖,D-(-)-Tagatose,D-塔格糖,d-tagatos

Target: Others, Endogenous Metabolite

Dihydrocapsaicin

Cat.No: T2163

Synonym: CCRIS1589,二氢辣椒素,6,7-Dihydrocapsaicin,8-Methyl-N-vanillylnonanamide

Target: Others, TRP/TRPV Channel

Epimedokoreanin B

Cat.No: TN3972

Target: Apoptosis, Others, Antibacterial

Cat.No: TN4177

Target: Others

Agatharesinol acetonide

Cat.No: TN3355

Target: Antifection

Cat.No: TN1642

Synonym: 铁锈罗汉柏醇

Target: BCL, PARP, Caspase

Cat.No: TN4355

Target: Others

Catechin-7-O-xyloside

Cat.No: TN5440

Synonym: Catechin 7-O-β-D-xylopyranoside

Target: Others

Griffipavixanthone

Cat.No: TN4166

Target: ERK, Raf, ROS, MEK, Caspase

Cat.No: T11009

Target: Others

1,3,9-Trimethyluric acid

Cat.No: TN6062

Soladulcoside A

Cat.No: T81132

Target: Others

Cat.No: TN4774

Target: ERK, BCL, p38 MAPK, NF-κB, Androgen Receptor, ROS, JAK, JNK, STAT, p53, Autophagy

Isoglobotriaose

Cat.No: T82032

Synonym: Gala-3Galb-4Glc

Cat.No: TN7505

Synonym: NSC 44707

Target: Others

Sartorypyrone B

Cat.No: T81201

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03958	TGF alpha Protein, Human, Recombinant transforming growth factor α,转化生长因子,transforming growth fact...	Human	E. coli
	The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (...
TMPH-01247	POLR3K Protein, Human, Recombinant (His) RNA polymerase III subunit C11,POLR3K,RNA polymerase III 12....	Human	Baculovirus Insect Cells
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase I...
TMPK-01034	SEMA4B Protein, Mouse, Recombinant (His) SEMA4B,SemC,Semaphorin-C,MGC131831,Semaphorin-4B,KIAA1745,SE...	Mouse	HEK293 Cells
	Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.
TMPK-00341	ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated ALCAM,KG-CAM,MEMD,CD166,CD6L	Human	HEK293 Cells
	Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed ...
TMPK-00339	ALCAM Protein, Mouse, Recombinant (His & Avi), Biotinylated CD6L,ALCAM,MEMD,KG-CAM,CD166	Mouse	HEK293 Cells
	Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian...
TMPK-00340	ALCAM Protein, Human, Recombinant (His & Avi), Biotinylated CD166,CD6L,KG-CAM,ALCAM,MEMD	Human	HEK293 Cells
	Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian...
TMPK-00906	PSCA Protein, Mouse, Recombinant (hFc) UNQ206,PSCA,PRO232	Mouse	HEK293 Cells
	Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein widely expressed in bladder, prostate, and pancreatic cancers. Existing studies have thoroughly recognized the availability of utilizing anti-PSCA CAR-T cells in the treatment of metastatic prostate cancer and non-small-cell lung cancer. PSCA Protein, Mouse, Recomb...
TMPK-00728	PSCA Protein, Human, Recombinant (hFc) UNQ206,PRO232,PSCA	Human	HEK293 Cells
	Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein widely expressed in bladder, prostate, and pancreatic cancers. Existing studies have thoroughly recognized the availability of utilizing anti-PSCA CAR-T cells in the treatment of metastatic prostate cancer and non-small-cell lung cancer. PSCA Protein, Human, Recomb...
TMPY-02391	SUMO1 Protein, Human, Recombinant (His) small ubiquitin-like modifier 1,SMT3C,SMT3,SMT3H3,U...	Human	E. coli
	Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX act...
TMPH-00864	RO60 Protein, Human, Recombinant (His) TROVE domain family member 2,RNA-binding protein RO60,Sjoegr...	Human	E. coli
	RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes.; May play roles in cilia formation and/or maintenance. RO60 Protein, Human, Recombinant (His)...
TMPJ-00063	CD160 Protein, Human, Recombinant (hFc) CD160 Antigen,CD160,BY55,Natural Killer Cell Receptor BY55	Human	HEK293 Cells
	CD160 antigen is a Lipid-anchor that exists as a disulfide-linked homomultimer. CD160 contains one Ig-like V-type domain. The human CD160 precursor is a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain. It is weakly homologous to KIR2DL4. CD160 is expressed in the spleen, peripheral blood, and small intestine. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. CD16...
TMPH-02380	RPB5 Protein, Kluyveromyces marxianus, Recombinant (His) RPB5,DNA-directed RNA polymerases I, II, and III subunit RPA...	Kluyveromyces marxianus	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol...
TMPH-01640	MRGPRX2 Protein, Human, Recombinant (His) Mas-related G-protein coupled receptor member X2,MRGPRX2	Human	E. coli
	Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway c...
TMPY-03986	PIST Protein, Human, Recombinant (His) CAL,dJ94G16.2,golgi-associated PDZ and coiled-coil motif con...	Human	E. coli
	GOPC, also known as PIST, interacts specifically with TC1 (a Rho-family small GTPase)] as a binding partner for Rhotekin. Rhotekin associates with PIST in vitro and both polarized and non-polarized MDCK (Madin-Darby canine kidney) cells. The C-terminal SPV (Ser-Pro-Val) motif of Rhotekin binds to the PDZ domain of PIST. The co-localization of PIST and Rhotekin at the Golgi apparatus can be detected in non-polarized fibroblast-like MDCK cells and AJs (adherens junctions) in the fully polarized ce...
TMPY-04375	Casein Kinase 1 alpha Protein, Human, Recombinant (GST) CKIa,casein kinase 1, alpha 1,casein kinase 1, α1,CK1a,Casei...	Human	Baculovirus Insect Cells
	Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are use...
TMPH-01246	POLR3A Protein, Human, Recombinant (His) RNA polymerase III subunit C160,RNA polymerase III 155 kDa s...	Human	E. coli
	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft ...
TMPY-04417	DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST) DAPK,death-associated protein kinase 1,ROCO3	Human	Baculovirus Insect Cells
	Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains tenANK repeats, onedeath domain and oneprotein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 g...
TMPY-02796	KIAA0101 Protein, Human, Recombinant (His) L5,NS5ATP9,p15PAF,OEATC1,p15(PAF),OEATC,PAF,p15/PAF,OEATC-1,...	Human	E. coli
	KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA binding partners and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF). KIAA11 is localized primarily in the nucleus. It shares the conserved PCNA binding motif with several other PCNA binding proteins including CDK inhibitor p21. KIAA11 is involved in cell ...
TMPJ-00281	CADM1 Protein, Mouse, Recombinant (hFc) IgSF4,NECL-2,Nectin-like protein 2,Immunoglobulin superfamil...	Mouse	HEK293 Cells
	Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in...
TMPH-02314	XRCC5 Protein, Human, Recombinant (His & MBP) Nuclear factor IV,Lupus Ku autoantigen protein p86,ATP-depen...	Human	Baculovirus Insect Cells
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...
TMPY-02399	TRF1 Protein, Human, Recombinant (His) TRF,telomeric repeat binding factor (NIMA-interacting) 1,hTR...	Human	Baculovirus Insect Cells
	Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1 protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Pin2/TRF1 was originally identified as a protein bound to telomeric DNA (TRF1) and as a protein involved in mitotic regulation (Pin2). Pin2/TRF1 negatively regulates telomere length and importantly, its function is tightly regulated during the cell ...
TMPY-04461	TRIB3 Protein, Human, Recombinant (GST) SKIP3,C20orf97,tribbles pseudokinase 3,TRB3,SINK,NIPK	Human	Baculovirus Insect Cells
	Tribbles homolog 3, also known as Neuronal cell death-inducible putative kinase, p65-interacting inhibitor of NF-kappa-B, SINK and TRIB3, is a Nucleus protein that belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family and Tribbles subfamily. Highest expression Of TRIB3 is in liver, pancreas, peripheral blood leukocytes and bone marrow. It is also highly expressed in a number of primary lung, colon and breast tumors. TRIB3 is expressed in spleen, thymus, and prostate an...
TMPY-02032	FLRT1 Protein, Human, Recombinant (His) SPG68,fibronectin leucine rich transmembrane protein 1	Human	HEK293 Cells
	The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT1 is expressed in kidney and brain, which is a target for tyrosine phosphorylation mediated by FGFR1 and implicates a non-receptor Src family kinase (SFK). All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. The phosphorylation ...
TMPH-02315	XRCC5 Protein, Human, Recombinant (His & Myc) ATP-dependent DNA helicase 2 subunit 2,XRCC5,Ku86,Nuclear fa...	Human	E. coli
	Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and bind...
TMPY-04455	PKC iota Protein, Human, Recombinant (GST) PKCI,nPKC-iota,protein kinase C, ι,DXS1179E,nPKC-ι,protein k...	Human	Baculovirus Insect Cells
	Protein kinase C iota type, also known as Atypical protein kinase C-lambda/iota, aPKC-lambda/iota and PRKCI, is a cytoplasm, membrane and nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and PKC subfamily. PRKCI contains one AGC-kinase C-terminal domain, one OPR domain, one phorbol-ester/DAG-type zinc finger and one protein kinase domain. PRKCI is predominantly expressed in lung and brain, but also expressed at lower levels in many tissues includ...

重组蛋白

TGF alpha Protein, Human, Recombinant

Cat.No: TMPY-03958

Species: Human

Expression System: E. coli

POLR3K Protein, Human, Recombinant (His)

Cat.No: TMPH-01247

Species: Human

Expression System: Baculovirus Insect Cells

SEMA4B Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01034

Species: Mouse

Expression System: HEK293 Cells

ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00341

Species: Human

Expression System: HEK293 Cells

ALCAM Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00339

Species: Mouse

Expression System: HEK293 Cells

ALCAM Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00340

Species: Human

Expression System: HEK293 Cells

PSCA Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00906

Species: Mouse

Expression System: HEK293 Cells

PSCA Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00728

Species: Human

Expression System: HEK293 Cells

SUMO1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02391

Species: Human

Expression System: E. coli

RO60 Protein, Human, Recombinant (His)

Cat.No: TMPH-00864

Species: Human

Expression System: E. coli

CD160 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00063

Species: Human

Expression System: HEK293 Cells

RPB5 Protein, Kluyveromyces marxianus, Recombinant (His)

Cat.No: TMPH-02380

Species: Kluyveromyces marxianus

Expression System: E. coli

MRGPRX2 Protein, Human, Recombinant (His)

Cat.No: TMPH-01640

Species: Human

Expression System: E. coli

PIST Protein, Human, Recombinant (His)

Cat.No: TMPY-03986

Species: Human

Expression System: E. coli

Casein Kinase 1 alpha Protein, Human, Recombinant (GST)

Cat.No: TMPY-04375

Species: Human

Expression System: Baculovirus Insect Cells

POLR3A Protein, Human, Recombinant (His)

Cat.No: TMPH-01246

Species: Human

Expression System: E. coli

DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)

Cat.No: TMPY-04417

Species: Human

Expression System: Baculovirus Insect Cells

KIAA0101 Protein, Human, Recombinant (His)

Cat.No: TMPY-02796

Species: Human

Expression System: E. coli

CADM1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00281

Species: Mouse

Expression System: HEK293 Cells

XRCC5 Protein, Human, Recombinant (His & MBP)

Cat.No: TMPH-02314

Species: Human

Expression System: Baculovirus Insect Cells

TRF1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02399

Species: Human

Expression System: Baculovirus Insect Cells

TRIB3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04461

Species: Human

Expression System: Baculovirus Insect Cells

FLRT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02032

Species: Human

Expression System: HEK293 Cells

XRCC5 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02315

Species: Human

Expression System: E. coli

PKC iota Protein, Human, Recombinant (GST)

Cat.No: TMPY-04455

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T11067	VX-984 M9831	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用，可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。
TMIH-0413	Osimertinib-d6
	Osimertinib-d6 是 Osimertinib 的氘代化合物。Osimertinib 的 CAS 号为 1421373-65-0。Osimtinib 是一种小分子酪氨酸激酶受体抑制剂和抗肿瘤剂，用于治疗选定形式的晚期非小细胞肺癌，其有效抑制 L858R 和 L858R/T790M EGFR，IC50 为 12 和 1 nM。
T72818	Dosimertinib-d3
	Dosimertinib-d3是一种有效的口服活性EGFR 抑制剂。Dosimertinib-d3降低 p-EGFR 和 p-ERK 蛋白水平的表达。Dosimertinib-d3显示出抗增殖和抗肿瘤活性。Dosimertinib-d3具有非小细胞肺癌 (NSCLC) 研究的潜力。
T35915	Erlotinib-13C6 Erlotinib-13C6
	Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]...

同位素标记化合物

Cat.No: T11067

Synonym: M9831

Target: DNA-PK

Cat.No: TMIH-0413

Dosimertinib-d3

Cat.No: T72818

Cat.No: T35915

Synonym: Erlotinib-13C6

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