Isoglobotriaose (Gala-3Galb-4Glc), a mammalian tissue glycosphingolipid, is a Globotriaose analogue. The ganglioside derivatives of Isoglobotriaose and Globotriaose differ in their small intestine distribution: isoglobotriaosylceramide localizes exclusively to the non-epithelial residue, whereas globotriaosylceramide is present in both compartments [1] [2].

Isoglobotriaose 是通过含有 UDP-glucose 激酶（GlaU）、UDP-Gal 4-差向异构酶（GalE）以及 α1-3半乳糖转移酶（α1-3GalT）的一锅三酶体系从乳糖、葡萄糖-1-磷酸（Glc-1-P）以及尿苷 5’-三磷酸（UTP）合成而成 [1]。