265
61
17
240
14
Cat. No. | Product Name | ||
---|---|---|---|
L3200 | 自噬库 | 1248 compounds | |
1248 种细胞自噬相关的生物活性小分子化合物的特有集合,用于自噬相关的研究,用于高通量、高内涵筛选; | |||
L1580 | GPCR库Plus | 338 compounds | |
338 种GPCR 靶向、结构新颖的化合物; | |||
L1500 | GPCR靶点分子库 | 1940 compounds | |
1940 种与 G 蛋白及其耦联受体相关的生物活性小分子化合物,所有小分子都具有良好的生物和药理活性,部分是 FDA 批准的上市药物; | |||
L2150 | 抗癌药物库 | 3080 compounds | |
3080 个具有抗癌活性小分子的独特集合,生物活性已经临床前实验证实,可用于高通量、高内涵筛选; | |||
L2160 | 抗癌活性化合物库 | 3188 compounds | |
3188 种具有抗肿瘤活性的化合物的特有集合,用于高通量、高内涵筛选; | |||
L3600 | 细胞因子抑制剂库 | 604 compounds | |
604 个与细胞因子紧密相关的化合物集合,是高通量、高内涵筛选的良好载体; | |||
L2120 | 抗癌临床化合物库 | 2545 compounds | |
2545 个具有抗癌活性小分子的独特集合,可用于高通量高内涵筛选。 | |||
L2110 | 抗癌上市药物库 | 1779 compounds | |
1779 个具有抗癌活性小分子的独特集合,所有化合物都经过了严格的临床前研究和临床试验,由FDA、EMA 或NMPA 批准上市,可用于高通量、高内涵筛选。 | |||
L2100 | 抗癌化合物库 | 7234 compounds | |
7234 种肿瘤相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L2180 | 抗肿瘤库Plus | 1468 compounds | |
1468 种抗肿瘤相关、结构新颖的化合物; | |||
L4010 | 已知活性化合物库 | 22555 compounds | |
22555 个已知活性化合物的集合,可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认; | |||
L4700 | 免疫/炎症分子化合物库 | 4720 compounds | |
4720 种具有抗炎症活性的化合物的特有集合,可用于高通量筛选和高内涵筛选; | |||
L2540 | 肠道微生物代谢化合物库 | 614 compounds | |
614 种肠道微生物代谢物的集合,可以用于高通量和高内涵筛选; | |||
L3800 | NF-κB 通路分子库 | 729 compounds | |
729 个 NF-κB 信号通路相关的小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L9420 | 外泌体相关化合物库 | 76 compounds | |
76 种外泌体相关的化合物,可以用于高通量和高内涵筛选; | |||
L2190 | 抗肺癌化合物库 | 1702 compounds | |
1702 种与肺癌相关的化合物,可以用于抗肺癌药物研发和药理研究; | |||
L2170 | 肿瘤免疫治疗小分子化合物库 | 449 compounds | |
449 种靶向肿瘤免疫治疗靶点的小分子,可用于高通量和高内涵筛选,是研究肿瘤免疫治疗的有力工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83705 |
BING TFA
Blocker of Inter-membrane Stress Responses of Gram-negative Bacteria |
||
BING是一种来源于日本稻田鱼(O. laptipes)的抗菌肽,由液泡蛋白质分选相关蛋白13D样(Vps13D)衍生而来。对包括耐甲氧西林的金黄色葡萄球菌(MRSA; MICs = 4-64 µg/ml)在内的各种革兰氏阴性和革兰氏阳性细菌都有活性。与氨苄西林、阿莫西林和新霉素共同使用时,对抗铜绿假单胞菌(P. aeruginosa)表现出协同效应,并能抑制大肠杆菌(E. coli)对卡那霉素和氨苄西林的抗药性发展。在体内,BING提高了被鳗弧菌(E. tarda)感染的O. laptipes的生存率。 | |||
T7954 |
YM976
|
PDE | Metabolism |
YM976 是磷酸二酯酶 4 抑制剂(IC50:2.2 nM)。它能够抑制抗原诱导的气道反应,并有抗炎的作用。 | |||
T38361 |
GSK717
|
IL Receptor; NOD | Immunology/Inflammation; NF-κB |
GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导,抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。 | |||
T7123 |
AMG-47a
|
VEGFR; p38 MAPK; JAK; Src | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors |
AMG-47a 是具有口服活性的 Lck 抑制剂,IC50值为 0.2 nM。它具有抗炎作用,对 VEGF2、p38α、p38α、Jak3、MLR 和 IL-2的 IC50值分别为 1、3、72、30 和 21 nM。 | |||
T3189 |
B7/CD28 interaction inhibitor 1
CTLA-4 inhibitor |
Others | Others |
B7/CD28 interaction inhibitor 1 (CTLA-4 inhibitor) 是B7.1-CD28相互作用抑制剂(IC50:50 nM)。 | |||
T7511 |
Cyclo(his-pro)
|
NF-κB; Endogenous Metabolite | Metabolism; NF-κB |
Cyclo(his-pro) 是一种口服具有活力的,结构上与促甲状腺激素释放激素相关的环状二肽。它能够抑制NF-κB 核积累,也能够穿越脑血屏障并影响多种炎症和应激反应。 | |||
T9079 |
Apostatin-1
Apt-1 |
Others | Others |
Apostatin-1 (Apt-1) 是一种新型 TRADD 抑制剂。 Apostatin-1 可以与 TRADD 的 N 末端 TRAF2 结合域上的口袋结合。 | |||
T3461 |
Losartan Carboxylic Acid
EXP-3174,E-3174 |
RAAS | Endocrinology/Hormones |
Losartan Carboxylic Acid (E-3174) 是 Losartan 的活性羧酸代谢产物,是血管紧张素Ⅱ受体 1 型(AT1)拮抗剂。它能够阻断血管紧张素 II 诱导的血管平滑肌细胞反应,可以提高血浆肾素活性,降低平均动脉压。 | |||
T4686 |
Simeprevir
TMC435,西咪匹韦,TMC-435350,Olysio |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Simeprevir (TMC435) 是一种有效的 HCV NS3/4A 蛋白酶抑制剂,抑制 HCV 复制,EC50 为 7.8 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。 | |||
T21608L |
β-Interleukin I (163-171), human Acetate
β-Interleukin I (163-171), human Acetate(106021-96-9 Free base) |
Others | Others |
β-Interleukin I (163-171), human Acetate 是一种参与调节免疫反应、炎症反应和造血的肽。 | |||
T77761 |
BMS-502
|
Others | Others |
BMS-502 是一种二酰基甘油激酶 (DGK) α 和 ζ 的强效双重抑制剂, 诱导人和小鼠T细胞的免疫反应,阻断 T 细胞中细胞内检查点信号传导。BMS-502 以剂量依赖的方式刺激免疫反应,可用于研究与免疫相关的疾病。 | |||
T20571 |
cis-PDA
哌啶-2,3-二羧酸,cis PDA |
GluR; NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
cis-PDA (cis PDA) 是一种通用的离子型受体拮抗剂。 cis-PDA 通过阻断 NMDA、AMPA 和红藻氨酸介导的反应发挥作用。 | |||
T28540 |
Ripisartan
UP 269-6,UP-2696,UP 2696,UP-269-6,UP269-6 |
RAAS | Endocrinology/Hormones |
Ripisartan (UP-269-6) 是一种强效的特异性血管紧张素 II 受体拮抗剂,对血管紧张素 II 介导的交感神经性心动过速反应有抑制作用。 | |||
T78082 |
Supercinnamaldehyde
|
NF-κB; Antibacterial; TRP/TRPV Channel | Membrane transporter/Ion channel; Microbiology/Virology; NF-κB |
Supercinnamaldehyde 是一种瞬时受体电位锚蛋白1(TRPA1)激活剂,具有千的抗癌和抗菌活性。Supercinnamaldehyde 抑制NF-κB信号传导,通过Nrf2诱导诱导细胞保护反应和抑制炎症反应。 | |||
T11877 |
LR-90
|
Others | Others |
LR-90, 作为一种高级糖基化终产品(AGE)抑制剂,在糖尿病动物模型研究中被广泛使用。LR-90 有效地抑制了人类单核细胞中的炎症反应。 | |||
T9292 |
ALE-0540
ALE0540 |
Others; Trk receptor | Others; Tyrosine Kinase/Adaptors |
ALE-0540是一种非肽类杂环分子,可抑制NGF 与p75和TrkA 的结合,以及TrkA 受体介导的信号转导和生物反应。 | |||
T11492 |
GSK2983559 free acid
|
Others; RIP kinase | Apoptosis; NF-κB; Others |
GSK2983559 free acid 是一种有效的特异性受体相互作用蛋白 2 (RIP2) 抑制剂。 GSK2983559 free acid 在阻断人类炎症性肠病外植体样品和体内的许多促炎细胞因子反应方面表现出优异的活性。 | |||
T12241 |
Norbinaltorphimine dihydrochloride
nor-BNI dihydrochloride,Nor-BNI dihydrochloride,nor-Binaltorphimine dihydrochloride,Nor-Binaltorphimine dihydrochloride |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Norbinaltorphimine dihydrochloride是一种具有选择性和有效性的κ阿片受体 (κ opioid receptor) 拮抗剂,可在小鼠中诱导瘙痒相关反应。 | |||
T13932 |
TLR1
N-[(1S)-2-甲基-1-(1-吡咯烷羰基)丙基]-苯丙酰胺 |
Others; MyD88 | Immunology/Inflammation; Others |
TLR1 是细胞穿透 Toll/IL-1 receptor/resistance (TIR) domain/BB-Loop 的小分子模拟物,能够阻碍 IL-1 受体介导的反应。 | |||
T36716 |
RO0270608
|
Integrin | Cytoskeletal Signaling |
RO0270608,是 R411 的活性代谢物,是一种具有口服活性的双重 α4β1/α4β7 整合素拮抗剂,具有抗炎活性,可调节炎症,可用于研究过敏性炎症反应。 | |||
T1076 |
Dexamethasone
MK 125,Prednisolone F,NSC 34521,Hexadecadrol,地塞米松 |
Glucocorticoid Receptor; Mitophagy; IL Receptor; SARS-CoV; Antibacterial; Antibiotic; Autophagy; Complement System; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Autophagy; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology |
Dexamethasone (Hexadecadrol) 是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。Dexamethasone 具有抗炎和免疫抑制活性,可诱导自噬。Dexamethasone 抑制 LPS 诱导的巨噬细胞炎症反应。 | |||
T35258 |
YM 16638
YM 638,YM-16638,YM16638 |
LTR | Immunology/Inflammation |
YM 16638 是一种具有口服活性的白三烯(LT)拮抗剂,具有降低甘油三酯和增加过氧化物酶体的作用,可用于研究抗原诱导过敏性绵羊早期和晚期气道反应。 | |||
T78181 |
MMP-7-IN-2
|
MMP; Others | Others; Proteases/Proteasome |
MMP-7-IN-2 可作为一种具有选择性和有效性的 MMP7 抑制剂,可用于研究炎症反应和与血管相关的疾病。 | |||
T2069L |
TH287 hydrochloride
|
DNA/RNA Synthesis; MTH1 | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
TH287 hydrochloride 是一种选择性MTH1抑制剂,IC50值为 0.8 nM。它可用于治疗癌症的研究。 | |||
T11630 |
IFN alpha-IFNAR-IN-1 hydrochloride
|
Others; IFNAR | Immunology/Inflammation; Others |
IFN alpha-IFNAR-IN-1 hydrochloride 是 IFN-α 和 IFNAR 相互作用的抑制剂。 IFN alpha-IFNAR-IN-1 hydrochloride 抑制 BM-pDCs 的 MVA 诱导的 IFN-α 反应,IC50 为 2-8 μM。 | |||
T9119 |
SU0268
|
Others | Others |
SU0268 是有效的 8-8-氧鸟嘌呤 DNA 糖基化酶1的选择性抑制剂,具有调控铜绿假单胞杆菌感染免疫反应的能力。 | |||
T19051 |
Reactive Blue 4
活性艳蓝X-ARL,活性蓝4 |
Others | Others |
Reactive Blue 4 是蒽醌类染料,具有植物毒性、细胞毒性和基因毒性。它可作为单一的比色化学传感器,用于在水介质中连续测定具有不同光学响应的多种分析物。 | |||
T14377 |
AZD5423
|
Glucocorticoid Receptor | Endocrinology/Hormones |
AZD5423 是可吸入的非甾体糖皮质激素受体选择性调节剂,能够有效降改善轻度过敏性哮喘患者的过敏原诱导反应。 | |||
T22414 |
RBN012759
|
PARP | Chromatin/Epigenetic; DNA Damage/DNA Repair |
RBN012759 是选择性和具有口服活性的 PARP14抑制剂,IC50值小于3 nM,可降低促肿瘤巨噬细胞功能并在肿瘤外植体中引发炎症反应,比对 monoPARPs 的选择性高 300 倍,比对 polyPARPs 的选择性高 1000 倍。 | |||
T4613 |
Arg-Gly-Asp TFA (99896-85-2(free base))
RGD Trifluoroacetate,RGD |
Integrin | Cytoskeletal Signaling |
Arg-Gly-Asp TFA (99896-85-2(free base)) (RGD Trifluoroacetate) 是一种三肽,可有效触发细胞粘附、定位某些细胞系并引发特定的细胞反应;与整合素结合。 | |||
T2401 |
Alogliptin Benzoate
苯甲酸阿格列汀,SYR 322,Alogliptin(SYR-322)benzoate |
Ferroptosis; Proteasome; DPP-4 | Apoptosis; Proteases/Proteasome; Ubiquitination |
Alogliptin Benzoate (SYR 322) 是一种有效且特异性的 DPP-4 抑制剂 ,IC50值小于 10 nM,其选择性比 DPP-8/9 高 10,000 倍以上,可用于研究 2 型糖尿病。 | |||
T5489 |
Tryptophan, N-indol-3-ylacetyl- (6CI)
N-(3-吲哚乙酰基)-L-色氨酸,N-(3-Indolylacetyl)-L-tryptophan,Indole-3-acetyl-L-tryptophan |
Glucosidase | Metabolism |
Tryptophan, N-indol-3-ylacetyl- (6CI) (Indole-3-acetyl-L-tryptophan) 参与调节生理和病理生理反应过程中生长素活性的调节机制。还可用于合成β-D-半乳糖苷酶和β-D-葡萄糖苷酶抑制剂。 | |||
T14513 |
BBIQ
|
TLR | Immunology/Inflammation |
BBIQ 是一种有效且选择性的 toll 样受体 7 (TLR7) 激动剂,对人 TLR7 的 EC50 为 59.1 nM。BBIQ 还是一种功能强大的疫苗佐剂,可增强机体的先天免疫应答。 | |||
T3977L |
Lifitegrast sodium
SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra |
Others | Others |
Lifitegrast sodium (SAR-1118) is an LFA-1 antagonist for the therapy of vascular complications of the eye. It inhibits T cell-mediated inflammation by blocking the binding of two cell surface proteins (lymphocyte function-associated antigen 1 and intercel | |||
T19930 |
Nitrosoglutathione
S-Nitrosoglutathione,S-亚硝基谷胱甘肽,SNOG,Glutathione thionitrite,GSNO |
RAAS; NO Synthase | Endocrinology/Hormones; Immunology/Inflammation |
Nitrosoglutathione (GSNO) 是一种外源性的 NO 供体,是大鼠酒精脱氢酶III 类同工酶的底物,能够减少脑血管紧张素II 依赖性及非依赖型的 AT1 受体反应。 | |||
TP2209L |
Xenin 8 acetate
Xenin 8 acetate (117442-28-1 Free base) |
IGF-1R | Tyrosine Kinase/Adaptors |
Xenin 8 acetate 是神经降压素/异视素家族中 Xenin 的生物活性片段。 Xenin 8 acetate 增强精氨酸诱导的胰岛素释放(40%)并增强胰高血糖素对精氨酸(60%)和卡巴胆碱(50%)的反应。 | |||
T10432L |
AZD-8529 mesylate
|
GluR | Neuroscience |
AZD-8529 mesylate 是高度选择性的可口服mGluR2正向调节剂,EC50值为 285 nM。它在 20-25 M 时,对 mGluR1、3、4、5、6、7 和 8 亚型没有显示正变构调节剂反应。 | |||
T76699 |
Sabatolimab
MBG453,NVP-MBG453 |
Others | Others |
Sabatolimab (MBG453) 是一种靶向 TIM-3的人源化 IgG4 (S228P) 抗体,是一种有效的调节适应性和先天免疫反应的抑制性受体。Sabatolimab 具有潜在的免疫抑制活性,可选择性与免疫细胞和骨髓细胞上的 TIM-3 结合。 | |||
T31615 |
Elsibucol
AGI-1096,UNII-O7T92N1Y8T,AGI 1096 |
Antioxidant | oxidation-reduction |
Elsibucol (AGI 1096) 是一种VCAM1抑制剂,可用于研究器官移植排斥。Elsibucol 是一种代谢稳定的丙醇衍生物,具有抗氧化、抗炎和抗增殖的特性。它能降低血液中的胆固醇水平,减少受伤动脉中的氧化应激和炎症反应,从而抑制动脉粥样硬化,保护动脉损伤后的内皮愈合。 | |||
T19723 |
AMTB hydrochloride
AMTB |
TRP/TRPV Channel | Membrane transporter/Ion channel |
AMTB hydrochloride (AMTB HCl) 是TRPM8通道的选择性阻滞剂。它抑制 icilin 诱导的 TRPM8 通道激活,pIC50为 6.23。它在膀胱过度活动和膀胱疼痛综合征中有研究的价值。它是电压门控钠通道的非选择性抑制剂 (NaV)。 | |||
T31195 |
Dalcotidine
KU 1257,KU-1257 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Dalcotidine (KU 1257) 是一种新型组胺H2受体拮抗剂,具有组胺H9受体拮抗活性和抗分泌作用,与豚鼠大脑皮层结合的Ki 值为0.040 对分离性豚鼠右心房组胺诱导的正变时反应的拮抗作用的KB 值为0.041。Dalcotidine 提高了溃疡愈合的质量,可能有助于降低溃疡的复发率和复发率。 | |||
T13867 |
RH01386
|
Others | Others |
RH01386是可以预防 ER 应激诱导的β细胞功能障碍和死亡、抑制促凋亡基因表达的小分子。它恢复内质网应激受损的葡萄糖刺激的胰岛素分泌反应。对2型糖尿病具有潜在的研究价值。 | |||
T11800 |
L-803087
|
Somatostatin | GPCR/G Protein |
L-803087 是一种具有高效性和选择性的生长抑素 sst4 受体激动剂,对 sst4 的 Ki 值为 0.7 nM,比其他生长抑素受体的选择性高 280 倍以上。L-803087 在体外诱导 AMPA 介导的海马突触反应,在体内增加了海藻酸盐促使的小鼠癫痫发作。 | |||
T3614 |
Inosine pranobex
Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun |
IL Receptor; HIV Protease | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Inosine pranobex (Delimmun) 是一种免疫增强剂,它是一种广谱抗病毒剂,用于 HIV 感染。 | |||
T16478 |
PF-04447943
PF 04447943,Edelinontrine,PF04447943 |
PDE | Metabolism |
PF-04447943 (Edelinontrine) 是一种有效且具有选择性的的磷酸二酯酶 9A 抑制剂,IC50 为 12 nM,比作用于其他PDE家族成员选择性高 78 倍 (IC50>1000 nM)。PF-04447943 具有抗炎活性,通过抑制氧化应激、炎症和调节T细胞极化来减轻炎症反应,且可用于研究镰刀型贫血症。 | |||
T0943 |
Carbamazepine
卡马西平,NSC 169864 |
Mitophagy; Sodium Channel; Autophagy | Autophagy; Membrane transporter/Ion channel |
Carbamazepine (NSC-169864) 是与三环抗抑郁药化学相关的三环化合物,具有抗惊厥和镇痛特性。它通过减少多突触反应和阻断强直后增强发挥其抗惊厥活性。 它通常用于治疗与三叉神经痛相关的疼痛。 | |||
T9897 |
7-Methoxy-1-naphthaleneacetic acid
|
Others | Others |
7-Methoxy-1-naphthaleneacetic acid 是植物生长素作用的抑制剂。 7-Methoxy-1-naphthaleneacetic acid 抑制与拟南芥和玉米中生长素不对称分布相关的极性生长素转运和热带反应。 7-Methoxy-1-naphthaleneacetic acid 抑制由酵母中表达的 AUX1、PIN 和 ABCB 蛋白介导的生长素转运。 | |||
T1435 |
Praziquantel
吡喹酮,Pyquiton,Droncit,Biltricide |
Calcium Channel; Antibiotic; Parasite | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Praziquantel (Droncit) 是一种外消旋混合物,由 (R)-Praziquantel 和 (S)-Praziquantel 组成。它可研究血吸虫病。 | |||
T4206 |
E6446
|
TLR | Immunology/Inflammation |
E6446 抑制 Toll 样受体 (TLR)7 和 9 信号传导。 E6446 在多种人和小鼠细胞类型中起作用,并在体外抑制 DNA-TLR9 相互作用。当给予小鼠时,该化合物抑制对刺激 TLR9 的含有胞苷-磷酸-胍 (CpG) 的 DNA 的挑战剂量的反应。 | |||
T50068 |
(2S,5S)-3,6-Dioxo-2,5-piperazinediacetamide
|
Others | Others |
2-[(2S,5S)-5-(carbamoylmethyl)-3,6-dioxopiperazin-2-yl]acetamide 是一种用作分子结构单元的化合物,为环状二肽。它可以诱导细胞凋亡、抑制细胞增殖和调节免疫反应,具有广泛的生物活性,包括抗肿瘤、抗真菌、抗细菌、抗病毒和免疫条件活性等。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5826 |
Eupalinolide A
|
HSP | Cytoskeletal Signaling; Metabolism |
Eupalinolide A 是分离于林泽兰中的一种天然产物,通过抑制 HSF1 与 HSP90 的相互作用,激活 HSF1,诱导 HSP70 的表达。它对 A-549、BGC-823、SMMC-7721 和 HL-60 肿瘤细胞系具有强大的细胞毒性。 | |||
T13502 |
3-Oxo-5β-cholanoic acid
3-氧代-5β-胆烷酸,Dehydrolithocholic acid |
ROR | Metabolism |
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) 是胆汁酸的一种代谢产物。3-Oxo-5β-cholanoic acid 直接与关键转录因子RORγt(Kd=1.13 μM) 结合抑制TH17细胞分化。 | |||
TN2088 |
Platycodin D2
桔梗皂苷D2 |
IL Receptor; HBV | Immunology/Inflammation; Microbiology/Virology |
Platycodin D2 是分离自桔梗的皂苷类物质,显示除抗癌活性。 | |||
T3319 |
Scutellarein
野黄芩素,4',5,6,7-Tetrahydroxyflavone,6-Hydroxyapigenin |
SARS-CoV; Src; Autophagy | Angiogenesis; Autophagy; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Scutellarein (6-Hydroxyapigenin) 是一种天然黄酮,具有抗炎功效。 | |||
T0948L |
Corticosterone
皮质酮,17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,肾上腺酮,Corticosterone (From plants) |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Corticosterone (Kendall's compound B) 是一种肾上腺皮质类固醇,有盐皮质激素和糖皮质激素的活性,具有口服活性。Corticosterone 参与体内能量、免疫反应和应激反应的调节。 | |||
T13557 |
Ascr#5
Ascaroside C3 |
Others | Others |
Ascr#5 (asc-ωC3)是秀丽隐杆线虫中高度保守的蛔苷类物质,可调节秀丽隐杆线虫的多种反应。 | |||
T5235 |
5-Methoxy-DL-tryptophan
|
Others; Endogenous Metabolite | Metabolism; Others |
5-Methoxy-DL-tryptophan 是内源性代谢产物的一种。 | |||
TN2349 |
Taurodeoxycholate sodium salt
Sodium taurodeoxylate,牛磺脱氧胆酸钠 |
Endogenous Metabolite | Metabolism |
Taurodeoxycholate sodium salt (Sodium taurodeoxylate) 是胆盐相关的阴离子洗涤剂,用于分离膜蛋白,包括线粒体内膜蛋白。它还可以抑制各种炎症反应。 | |||
TN1052 |
Lindleyin
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Lindleyin 是从 Rhei rhizoma 中分离得到,通过雌激素受体介导激素作用。它能够与 ERα结合,有类似雌激素的作用。 | |||
TN1594 |
DL-Syringaresinol
(±)-Syringaresinol |
Antioxidant; Antifungal | Microbiology/Virology; oxidation-reduction |
DL-Syringaresinol ( (±)-Syringaresinol) 是一种来自与人参浆果的木质素,具有抗炎、抗氧化、镇痛活性和较弱的抗分枝杆菌活性。DL-Syringaresinol 可通过自噬延缓氧化应激诱导的皮肤老化,通过抑制炎症反应来缓解奥沙利铂诱导的神经性疼痛和脓毒症引起的心功能障碍。 | |||
TN6457 |
N-trans-caffeoyltyramine
Trans-N-Caffeoyltyramine,N-(E)-Caffeoyl-lambda-tyramine,N-cis-Caffeoyltyramine,Typheramide |
Immunology/Inflammation related | Immunology/Inflammation |
N-trans-caffeoyltyramine (Trans-N-Caffeoyltyramine) 是炎症反应的调节剂,可用于慢性炎症性疾病治疗的研究。 | |||
T13555 |
Ascr#2
Ascaroside C6 |
Others | Others |
Ascr#2 (asc-C6-MK)是秀丽隐杆线虫中的糖苷类化合物,促进 dauer 形成。Ascr#2 在低浓度下与 ascr#3 的混合物可作为雄性引诱剂,可用于检测种群密度。 | |||
T67710 |
3-Indoleacrylic acid
|
Endogenous Metabolite | Metabolism |
3-Indoleacrylic acid 是由链球菌属产生的色氨酸的代谢产物。3-Indoleacrylic acid 对肠上皮屏障功能有有益作用,并减轻免疫细胞的炎症反应。 | |||
T5731 |
1-Kestose
蔗果三糖,1-蔗果三糖 |
Others; Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology; Others |
1-Kestose 是低聚果糖成分,有效刺激了 Faecalibacterium prausnitzii 和 Bifidobacteria。它有抗羟基自由基的潜力。它可促进肠道内乳酸菌数量,影响微生物以及肠道和全身免疫反应。 | |||
T2842 |
Tangeretin
NSC53909,Tangeritin,NSC618905,桔皮素 |
Apoptosis; Gamma-secretase | Apoptosis; Neuroscience; Proteases/Proteasome; Stem Cells |
Tangeretin (NSC-618905) 是一种来自柑橘类水果果皮的类黄酮,是一种Notch-1抑制剂,具有抗炎,保护神经等作用。 | |||
TN1879 |
Lucideric acid A
Lucidenic acid A,赤芝酸A |
MMP; p38 MAPK; JNK | MAPK; Proteases/Proteasome |
Lucideric acid A (Lucidenic acid A) 是分离自灵芝的天然产物,可抑制 PMA 诱导的MMP-9活性,具有抵抗肝癌细胞侵袭的作用。 | |||
T6S0657 |
Isorhynchophylline
IsoRhy,异钩藤碱,Isorhyncophylline,Isorhychophylline,7-Isorhyncophylline |
Others | Others |
Isorhynchophylline (7-Isorhyncophylline) 是一种分离自钩藤中的生物碱类化合物,具有舒张血管、降血压、保护神经免于局部缺血造成损伤的作用。 | |||
T5S0089 |
Kaempferol-3-O-glucorhamnoside
Kaempferol 3-glucorhamnoside,百蕊草素I |
Antioxidant; p38 MAPK; NF-κB | MAPK; NF-κB; oxidation-reduction |
Kaempferol-3-O-glucorhamnoside (Kaempferol 3-glucorhamnoside) 是来源于百蕊草的一种类黄酮,在体内外均能通过 MAPK 和 NF-κB 通路抑制炎症反应。 | |||
T4939 |
Indole-3-pyruvic acid
3-(3-吲哚基)-2-氧代丙酸,3-(3-Indolyl)-2-oxopropanoic acid |
Others | Others |
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) 是一种参与Indole-3-acetic acid 生物合成的化合物,Indole-3-acetic acid 是一种植物激素,在调节生长和对环境变化的反应中起重要作用。 | |||
T1614 |
Hydrocortisone
氢化可的松,Cortisol |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Hydrocortisone (Cortisol) 是一种糖皮质激素,由肾上腺素皮质分泌。Hydrocortisone 激动糖皮质激素受体,可促进蛋白质分解代谢、糖异生、毛细血管壁稳定性、肾脏钙排泄,并抑制免疫和炎症反应。 | |||
TN1134 |
Euscaphic acid
|
Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling |
Euscaphic acid 是来源于枣的一种三萜,是DNA 聚合酶抑制剂,可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。 | |||
T5S0993 |
Kurarinone
苦参酮,苦参黄素 |
BCL; Others; IκB/IKK; TNF; NF-κB; JAK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; Others; Stem Cells |
Kurarinone 是从灌木苦参中提取的黄酮类化合物,具有抗肿瘤、雌激素和抗炎活性,对免疫反应也有很强的抑制作用。 | |||
T1004 |
6-Benzylaminopurine
6-苄氨基嘌呤,6-BAP,N6-Benzyladenine,BA,Benzyladenine |
Others | Others |
6-Benzylaminopurine (6-BAP) 是一种细胞分裂素,能够通过刺激细胞分裂引起植物生长和发育,抑制呼吸激酶,从而延长绿色蔬菜的保鲜。 | |||
TN6774 |
Emodin 6-O-β-D-glucoside
大黄素-6-O-β-D-葡萄糖苷,Glucoemodin |
Others | Others |
Emodin 6-O-β-D-glucoside (Glucoemodin) 是一种从 Reynoutria japonica 中提取的活性化合物。它具有显著的抗炎和屏障保护活性,可用于研究动脉粥样硬化及糖尿病并发症。 | |||
T5S1895 |
Norisoboldine
Laurelliptine,去甲异波尔定,(+)-Laurelliptine |
MAPK; Adenosine Receptor | GPCR/G Protein; MAPK; Neuroscience |
Norisoboldine ((+)-Laurelliptine) 是一种可口服的芳基烃受体激动剂,是乌药中主要的异喹啉类生物碱,可用于类风湿性关节炎和溃疡性结肠炎的研究。 | |||
T4928 |
L-Kynurenine
L-犬尿氨酸,(S)-Kynurenine |
AhR; Aryl Hydrocarbon Receptor; Endogenous Metabolite | Immunology/Inflammation; Metabolism |
L-Kynurenine ((S)-Kynurenine) 是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
T5S1177 |
Aloin B
Isobarbaloin,芦荟苷B,芦荟素B |
Others | Others |
Aloin B (Isobarbaloin) 是一种芦荟素的异构体。其中芦荟素是芦荟中的具生理活性蒽醌化合物。 | |||
T1611 |
Isotretinoin
13-cis-Retinoic acid,异维A酸 |
Retinoid Receptor; Endogenous Metabolite; Autophagy | Autophagy; Metabolism |
Isotretinoin (13-cis-Retinoic acid) 是一种天然存在的维甲酸,具有潜在的抗肿瘤活性。 它结合并激活核视黄酸受体 (RAR), 活化的 RARs 作为促进细胞分化和凋亡的转录因子。它是一种类维生素A 和维生素A 衍生物,用于治疗严重的痤疮和某些形式的皮肤、头颈癌。 | |||
T5S1286 |
(+)-Columbianetin
二氢山芹醇,(S)-Columbianetin,Columbianetin |
Antifungal | Microbiology/Virology |
(+)-Columbianetin ((S)-Columbianetin) 是 Columbianetin 的异构体。其中Columbianetin 是一种植物抗毒素,与芹菜贮藏过程中对病原体的抗性有关,具有良好的抗真菌和抗炎作用。 | |||
T3386 |
Kaempferitrin
Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷 |
cell cycle arrest; Glucokinase; IGF-1R | Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors |
Kaempferitrin (Lespenephryl) 是天然黄酮苷类化合物,具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用,可激活胰岛素信号传导。 | |||
T3S0364 |
L-Arginine
L-精氨酸,L-Arg,(S)-(+)-Arginine |
IL Receptor; Endogenous Metabolite; NO Synthase | Immunology/Inflammation; Metabolism |
L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞,并被代谢成一氧化氮、多胺或 L-脯氨酸。 | |||
T3877 |
Esculentoside A
|
NF-κB; COX | Immunology/Inflammation; Neuroscience; NF-κB |
Esculentoside A 是一种三萜皂苷,从商陆根部分离得到。它在具有抗炎活性,对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。 | |||
T4868 |
gamma-Linolenic acid
gamolenic acid,γ-Linolenic acid,γ-亚麻酸 |
Endogenous Metabolite | Metabolism |
gamma-Linolenic acid (gamolenic acid) 是一种 omega-6 (n-6),18 碳 (18C-) 多不饱和脂肪酸 (PUFA),可以从人乳和植物种子油中提取。 | |||
T11855 |
Lipopolysaccharides
脂多糖,LPS |
Others | Others |
Lipopolysaccharides (LPS) 是革兰氏阴性细菌细胞壁的一种特有成分,由脂质A、寡糖核心和 O -特异性多糖 (O-antigen) 3个区域组成。Lipopolysaccharides 有利于维持细胞外膜的完整性,保护细菌免受胆汁盐和脂类抗生素的破坏。Lipopolysaccharides 是一种高免疫原性抗原,可以增强免疫反应,可以用于炎症模型构建。 | |||
T3S0737 |
Flavokawain A
2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A |
Apoptosis; p38 MAPK | Apoptosis; MAPK |
Flavokawain A (Flavokavain A) 是 kava 提取物中的查耳酮,是一种抗癌试剂,具有抗肿瘤活性。它通过 Bax 蛋白依赖和线粒体依赖的凋亡途径诱导细胞凋亡,有潜力用于膀胱癌的相关研究。 | |||
T3673 |
Mollugin
大叶茜草素,Rubimaillin |
HER; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
Mollugin (Rubimaillin) 是Rubia cordifolia L.中主要的生物活性成分。它能通过 p38-Smad 信号通路增强 BMP-2 的成骨作用。它通过抑制 TNF-α 诱导的 NF-κB 激活起抗癌疗效。 | |||
T4S2126 |
Ginkgetin
银杏双黄酮,银杏素 |
Apoptosis; Wnt/beta-catenin; COX; STAT; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells |
Ginkgetin 是从银杏叶中分离得到的一种双黄酮,具有抗肿瘤、抗炎、神经保护、抗真菌的作用。它也是 Wnt 信号抑制剂,IC50值为 5.92 μM。 | |||
T41078 |
Lipopolysaccharides, Escherichiacoli
Lipopolysaccharide, E. coli O111:B4 |
Others | Others |
Lipopolysaccharides, Escherichiacoli (E. coli O111:B4) 是革兰氏阴性细菌细胞壁的一种特有成分,由脂质A、寡糖核心和 O -特异性多糖 (O-antigen) 3个区域组成。Lipopolysaccharides, Escherichiacoli 有利于维持细胞外膜的完整性,保护细菌免受胆汁盐和脂类抗生素的破坏。Lipopolysaccharides, Escherichiacoli 是一种高免疫原性抗原,可以增强免疫反应,可以用于炎症模型构建。 | |||
T4S2326 |
Cornuside
7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside |
ERK; p38 MAPK; NF-κB; JNK | MAPK; NF-κB |
Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷,可用于炎症疾病的研究和促进血液循环。 它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应,用于炎性过敏性疾病中的潜能。 | |||
T35749 |
Thymohydroquinone
Thymoquinol |
Antioxidant; Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
Thymohydroquinone (Thymoquinol) 是中药材百里香、牛至和其他唇形科植物中含有的单萜酚类化合物。 Thymohydroquinone 抑制癌细胞生长、减少氧化应激和调节炎症反应,在无细胞实验中清除2,2-二苯基-1-picrylhydrazyl 自由基(IC50 = 2.4 μg/ml),在浓度为1.6至6.4 μg/ml 的氧自由基吸收能力(ORAC)实验中,它的Trolox 当量值为2.6胸腺对苯二酚对A2780、OVCAR-8和CIS-A2780卵巢癌细胞(IC50分别为3.1、8.9和9.8 μM)和人卵巢永生化上皮细胞(IC50 = 14 μM)的生长有抑制作用,体外对恶性疟原虫也有抑制作用(IC50 = 15.9 μM)。 | |||
TN4804 |
Platycoside A
|
Antifection | Microbiology/Virology |
Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. It induces the IgG and IgG1 antibody responses in the immunized mice. | |||
T20217 |
Grandiflorenic acid
|
Others | Others |
Grandiflorenic acid can reproduce the uterine responses induced by aqueous extract of zoapatle leaves. It is suggested that grandiflorenic acid may have an antifertility effect. | |||
TN4882 |
Quinine HCl
奎宁树 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Quinine HCl produces alpha-adrenergic blockade. Quinine modifies catecholamine- and calcium-induced myocardial contractile force responses. | |||
T39179 |
β-Tomatine
|
Others | Others |
β-Tomatine, a derivative of α-tomatine, is a fungitoxic compound that efficiently inhibits plant defense responses. | |||
TN3482 |
Bakkenolide B
|
NOS; COX | Immunology/Inflammation; Neuroscience |
Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma. | |||
T13968 |
Xanthoplanine
|
Others | Others |
Xanthoplanine is a natural product isolated from theroot of Xylopia parviflora, and inhibits the EC50 ACh responses of both alpha7 and alpha4beta2 nACh receptors (IC50 of 9 μM and 5 μMc for alpha7 and alpha4beta2,respectively). | |||
TN4420 |
Latifolin
檀木 |
IL Receptor; IκB/IKK; TNF; NOS; NF-κB; COX; Nrf2; Prostaglandin Receptor; Antifection; Autophagy | Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience; NF-κB |
Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays potent anticarcinogenic phase II marker enzyme, quinone reductase (QR) inducing activity and high chemopreventive indices. Latifolin also shows antifungal activity against white- and brown-rot fungi. | |||
T83600 |
(+)-Dihydrocarvone
|
||
(+)-Dihydrocarvone对A. mellifera的触角产生显著反应,并影响其对番茄的觅食行为偏好。 | |||
TN7276 |
Methyl 7(Z)-hexadecenoate
Methyl cis-7-hexadecenoate |
Others | Others |
Methyl 7(Z)-hexadecenoate 是Trogoderma glabrum 生产的一种性信息素,能够吸引并引发雄性Trogoderma glabrum 的性兴奋反应。 | |||
T61171 |
Cyclo(his-pro) TFA
|
Others | Others |
Cyclo(his-pro) TFA, an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone, has shown inhibitory effects on NF-κB nuclear accumulation. Additionally, it possesses the ability to cross the blood-brain barrier and impact various inflammatory and stress responses [1, 2]. | |||
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Cat. No. | Product Name | Species | Expression System |
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TMPK-00047 |
IFN gamma Protein, Human, Recombinant (His & Avi)
IFN gamma,interferon,Interferon-γ,γ,IFI,干扰素,Interferon-gamma... |
Human | HEK293 Cells |
Interferon-gamma (IFN gamma) is a cytokine that plays physiologically important roles in promoting innate and adaptive immune responses. The absence of IFN gamma production or cellular responsiveness in humans and experimental animals significantly predisposes the host to microbial infection, a result that validates the physiologic importance of this cytokine in preventing infectious disease. IFN gamma Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi ... | |||
TMPK-00022 |
Galectin-1 Protein, Human, Recombinant (hFc)
GAL1,LGALS1,Galectin-1,S-Lac lectin 1,DKFZp686E23103,GBP,Gal... |
Human | HEK293 Cells |
Galectin 1 (Gal-1), a β-galactoside binding mammalian lectin of 14KDa, is implicated in many signalling pathways, immune responses associated with cancer progression and immune disorders. Inhibition of human Gal-1 has been regarded as one of the potential therapeutic approaches for the treatment of cancer, as it plays a major role in tumour development and metastasis by modulating various biological functions viz. apoptosis, angiogenesis, migration, cell immune escape. | |||
TMPJ-00735 |
PDGF-BB Protein, Human, Recombinant
PDGF-BB,血小板源生长因子,PDGFBB |
Human | E. coli |
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In a... | |||
TMPJ-00864 |
VEGF165 Protein, Human, Recombinant
Vascular Endothelial Growth Factor Isoform 165,血管内皮生长因子,VEGF... |
Human | HEK293 Cells |
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul... | |||
TMPY-05510 |
BDNF Protein, Mouse, Recombinant (His)
brain-derived neurotrophic factor |
Mouse | HEK293 Cells |
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth,... | |||
TMPY-02603 |
STAT6 Protein, Human, Recombinant (His)
STAT6C,IL-4-STAT,STAT6B,signal transducer and activator of t... |
Human | Baculovirus Insect Cells |
Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators... | |||
TMPJ-01204 |
TPSAB1 Protein, Human, Recombinant (His)
TPS1,tryptase alpha/beta 1,TPS2,tryptase α/β1,tryptase α/β 1... |
Human | HEK293 Cells |
Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G, tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1), also known as mast cell protease 7 (MCPT7), it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung, stomach, spleen, heart and s... | |||
TMPY-02904 |
TLR4 Protein, Human, Recombinant (His)
TLR-4,TOLL,toll-like receptor 4,ARMD10,TLR4,CD284 |
Human | Baculovirus Insect Cells |
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed... | |||
TMPY-06981 |
IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
interleukin 1 α,IL1,白介素,IL-1F1,IL1-α,IL-1A,IL1F1,白细胞介素,IL-1 ... |
Human | E. coli |
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage... | |||
TMPJ-00387 |
IL-4R alpha Protein, Mouse, Recombinant (hFc)
Soluble IL-4R-alpha,Interleukin-4 receptor subunit alpha,Sol... |
Mouse | HEK293 Cells |
Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic ... | |||
TMPJ-00137 |
APRIL/TNFSF13 Protein, Human, Recombinant (Flag & His)
TRDL-1,TNF- and APOL-related leukocyte expressed ligand 2,Tu... |
Human | HEK293 Cells |
APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL, which consists almost entirely of a single TNF homology domain, shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily recept... | |||
TMPY-02153 |
TNF beta Protein, Human, Recombinant
LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymphotoxin alpha,lymphotoxin α |
Human | E. coli |
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS... | |||
TMPY-04552 |
AKT1 Protein, Human, Recombinant (His)
RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1,RAC,... |
Human | Baculovirus Insect Cells |
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac... | |||
TMPJ-00042 |
TSLP Protein, Human, Recombinant
TSLP,Thymic stromal lymphopoietin |
Human | E. coli |
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing . lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral... | |||
TMPY-02550 |
Eotaxin/CCL11 Protein, Human, Recombinant (His)
SCYA11,chemokine (C-C motif) ligand 11 |
Human | E. coli |
CCL11 or chemokine (C-C motif) ligand 11 is a member of the chemokine (C-C motif) ligand family. Chemokin (C-C motif) ligand 11 is a member of the chemokine family. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. Chemokines are a family of small ... | |||
TMPY-04483 |
IRAK4 Protein, Human, Recombinant (His)
IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas... |
Human | Baculovirus Insect Cells |
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ... | |||
TMPY-02219 |
Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His)
NS1 Protein |
H1N1 | E. coli |
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the NS2 protein, which mediates the export of vRNPs. The non-structural (NS1) protein is found in Influenzavirus A, Influenzavirus B, and Influenzavirus C. The non-structural (NS1) protein of the highly pathogenic avian H5N1 viruses circulating in poultry and waterfowl in Southeast As... | |||
TMPY-03443 |
NDRG1 Protein, Human, Recombinant (His)
TARG1,PROXY1,RIT42,NDR1,DRG1,RTP,TDD5,CMT4D,CAP43,NMSL,N-myc... |
Human | E. coli |
NDRG1 gene is a member of the N-Myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. NDRG1 is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. NDRG1 is necessary for p53-mediated caspase activation and apoptosis. Mutations in the NDRG1 gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. NDRG1 is a stress-responsive pro... | |||
TMPJ-00446 |
CD32A Protein, Human, Recombinant (R167, His)
FcRII-a,IGFR2,Low Affinity Immunoglobulin Gamma Fc Region Re... |
Human | HEK293 Cells |
Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), which generate multiple isoforms, are recognized. The activating type receptor either has or associates noncovalently with an accessory subunit that has an immunoreceptor tyrosinebased activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG... | |||
TMPK-00123 |
CD8 alpha Protein, Human, Recombinant (aa 22-182, His & Avi), Biotinylated
Leu2,CD8 α/CD8A,MAL,Lyt-2,OKT8 T-cell antigen,CD8a molecule,... |
Human | HEK293 Cells |
CD8 alpha enhances the responses of antigen-specific CTL activated through TCR through binding MHC class I, favoring lipid raft partitioning of TCR, and inducing intracellular signaling. CD8 alpha is also found on dendritic cells and rat macrophages, but whether CD8 alpha enhances responses of a partner receptor, like TCR, to activate these cells is not known. | |||
TMPH-01542 |
ITIH4 Protein, Human, Recombinant (His & SUMO)
Inter-alpha-trypsin inhibitor heavy chain H4,ITIH4,Plasma ka... |
Human | E. coli |
Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. | |||
TMPH-02688 |
Granzyme C/GZMC Protein, Mouse, Recombinant (His & Myc)
Cytotoxic cell protease 2,B10,Gzmc,Granzyme C |
Mouse | E. coli |
This enzyme is probably necessary for target cell lysis in cell-mediated immune responses. Granzyme C/GZMC Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.6 kDa and the accession number is P08882. | |||
TMPH-01541 |
ITIH4 Protein, Human, Recombinant (His)
ITIH4,Inter-alpha-trypsin inhibitor heavy chain H4,Inter-alp... |
Human | P. pastoris (Yeast) |
Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. | |||
TMPK-00698 |
AGR2 Protein, Mouse, Recombinant (His)
AG2,HPC8,hAG-2,Anterior gradient protein 2 homolog,AG-2,hAG ... |
Mouse | E. coli |
Anterior gradient homolog 2 (AGR2) is a functional protein with critical roles in a diverse range of biological systems, including vertebrate tissue development, inflammatory tissue injury responses, and cancer progression. | |||
TMPH-01717 |
CHRM5 Protein, Human, Recombinant (His)
CHRM5,Muscarinic acetylcholine receptor M5 |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.5 kDa and the accession number is P08912. | |||
TMPJ-00030 |
IL-1F10 Protein, Human, Recombinant
Interleukin-1 Family Member 10,白介素,Interleukin-1 HY2,FIL1T,F... |
Human | E. coli |
Human Interleukin 1 Family Member 10 (IL-1F10) is thought to participate in a network of Interleukin 1 cytokine family members to regulate adapted and innate immune responses. IL-1F10 was expressed in fetal skin, spleen and tonsil, mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil. IL-1F10 binds soluble IL-1 receptor type 1 and may be implicated in regulating adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protei... | |||
TMPH-03338 |
CHRM1 Protein, Rat, Recombinant (His)
Muscarinic acetylcholine receptor M1,CHRM1 |
Rat | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.1 kDa and the accession number is P08482. | |||
TMPK-01543 |
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi)
LAGE2A,ESO1CTAG,LAGE-2,CTAG1,CT6.1,MHC,MY-ESO-1,NY-ESO-1,CTA... |
Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. | |||
TMPK-01499 |
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Tetramer Protein, Human, MHC (His & Avi)
ESO1CTAG,LAGE-2,CTAG1B,LAGE2A,MY-ESO-1,CT6.1,NY-ESO-1,CTAG1,... |
Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. | |||
TMPK-01497 |
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled
MY-ESO-1,MHC,ESO1CTAG,NY-ESO-1,CTAG1,LAGE2A,LAGE-2,CT6.1,CTA... |
Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. | |||
TMPH-01716 |
CHRM3 Protein, Human, Recombinant (B2M & His)
Muscarinic acetylcholine receptor M3,CHRM3 |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM3 Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 40.7 kDa and the accession number is P20309. | |||
TMPK-00598 |
Fc gamma RIIIA/CD16a (V176) Protein, Human, Recombinant (His & Avi), Biotinylated
Fc gamma RIIIA,Fc γ RIIIA,FCGR3,FcRIII,FCG3,IGFR3,FCGR3A,FcR... |
Human | HEK293 Cells |
The Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. | |||
TMPK-01500 |
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQV) Monomer Protein, Human, MHC (His & Avi)
CTAG1,CT6.1,CTAG1B,LAGE2A,MY-ESO-1,LAGE-2,MHC,NY-ESO-1,ESO1C... |
Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. | |||
TMPK-01539 |
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (His & Avi), Biotinylated
CTAG1B,CT6.1,MY-ESO-1,LAGE2A,NY-ESO-1,MHC,LAGE-2,ESO1CTAG,CT... |
Human | HEK293 Cells |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. | |||
TMPK-01449 |
HLA-A*02:01&B2M&NY-ESO-1 (SLLMWITQC) Monomer Protein, Human, MHC (E. coli, His & Avi)
MHC,CT6.1,CTAG1,LAGE-2,MY-ESO-1,NY-ESO-1,ESO1CTAG,LAGE2A,CTA... |
Human | E. coli |
NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. | |||
TMPK-01040 |
NKG2C/CD159c Protein, Cynomolgus, Recombinant (His)
NKG2C,NK cell receptor C,CD159c,KLRC2 |
Cynomolgus | HEK293 Cells |
As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. The presented study is the first of its kind that ascribes CD56dimCD16 NKG2C-expressing NK cells a crucial role in biasing adaptive immune responses upon influenza vaccination and suggests NKG2C as a potential biomarker in predicting pandemic influenza vaccine responsiveness. | |||
TMPK-01230 |
CLEC2D Protein, Human, Recombinant (hFc & Avi)
Lectin-like NK cell receptor,LLT-1,OCIL,LLT1,Lectin-like tra... |
Human | HEK293 Cells |
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. However, this implication may be confounded by highly active anti-retroviral treatment (HAART). | |||
TMPK-00599 |
Fc gamma RIIIA/CD16a (V176) Domain 2 Protein, Human, Recombinant (mFc)
FCGR3,IGFR3,FcR-10,Fc γ RIIIA/CD16a (V176) Domain 2 Protein,... |
Human | HEK293 Cells |
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (V176) Domain 2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 35.29 kDa and the accession number is AAH17865. | |||
TMPH-03332 |
OPN4 Protein, Rat, Recombinant (His)
Opn4,Melanopsin,Opsin-4 |
Rat | E. coli |
Photoreceptor that binds cis-retinaldehydes. Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light. May be involved in the optokinetic visual tracking response. May be involved in the regulation of retinal hyaloid vessel growth and regression. OPN4 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 53.9 kDa and the accession number is Q8R456. | |||
TMPH-01714 |
CHRM1 Protein, Human, Recombinant (His)
Muscarinic acetylcholine receptor M1,CHRM1 |
Human | E. coli |
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.8 kDa and the accession number is P11229. | |||
TMPK-01192 |
Varicella-zoster virus (strain Oka vaccine) Envelope glycoprotein E Protein (His)
Envelope glycoprotein E,ORF68,gE |
Varicella-zoster virus (strain Oka vaccine) | HEK293 Cells |
VZV glycoprotein E (gE) is most abundantly expressed on the surface of infected cells, and is an essential component for virus replication and cell-to-cell transmission. It is also the main target of virus-specific antibodies and T cell responses that is often selected as vaccine candidate antigen. | |||
TMPK-01231 |
CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated
OCILmember D,LLT1,CLAX,CLEC2D,CLAXLLT-1,LLT-1,OCIL |
Human | HEK293 Cells |
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. | |||
TMPK-00565 |
PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His)
PSGL-1,CD162,SELPLG,PSGL1,Selectin P ligand,Selpl,CLA,Selp1 |
Cynomolgus | HEK293 Cells |
P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. PSGL-1/CD162 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 34.57 kDa and the accession number is A0A7N9CVJ8. | |||
TMPK-00970 |
FGL2 Protein, Human, Recombinant (hFc & Flag)
pT49,fibrinogen-like 2,Fibroleukin,FGL2 |
Human | HEK293 Cells |
Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses. FGL2 is overexpressed in glioma, and its expression level is negatively associated with the prognosis of glioma patients. FGL2 Protein, Human, Recombinant (hFc & Flag) is expressed in HEK293 mammalian cells with N-hFc-Flag tag. The predicted molecular weight is 54.73 kDa and the accession number is Q14314. | |||
TMPK-00829 |
Galectin-1 Protein, Mouse, Recombinant (hFc)
GBP,DKFZp686E23103,S-Lac lectin 1,GAL1,Galectin-1,HLBP14,LGA... |
Mouse | HEK293 Cells |
Galectin 1(Gal-1), a β-galactoside binding mammalian lectin of 14KDa, is implicated in many signalling pathways, immune responses associated with cancer progression and immune disorders. Inhibition of human Gal-1 has been regarded as one of the potential therapeutic approaches for the treatment of cancer, as it plays a major role in tumour development and metastasis by modulating various biological functions viz. apoptosis, angiogenesis, migration, cell immune escape. | |||
TMPH-02879 |
REG3G Protein, Mouse, Recombinant (His)
Regenerating islet-derived protein III-gamma,Reg3g,Pancreati... |
Mouse | P. pastoris (Yeast) |
Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regula... | |||
TMPK-00536 |
FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag), Biotinylated
Fibroleukin,pT49,FGL2,fibrinogen-like 2 |
Cynomolgus | HEK293 Cells |
Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses. FGL2 is overexpressed in glioma, and its expression level is negatively associated with the prognosis of glioma patients. FGL2 Protein, Cynomolgus, Recombinant (His & Avi, Flag), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi and N-Flag tag. The predicted molecular weight is 31.40 kDa and the accession nu... | |||
TMPK-00439 |
SARS-COV-2 Spike RBD Protein (His & Avi), Biotinylated
S protein RBD,S glycoprotein RBD,Spike protein RBD |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession nu... | |||
TMPK-00912 |
SARS Spike RBD Protein (His & Avi), Biotinylated
S glycoprotein RBD,S protein RBD,Spike protein RBD |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.9 kDa and the accession number... | |||
TMPK-00814 |
FGL2 Protein, Mouse, Recombinant (His & Avi, Flag), Biotinylated
FGL2,Fibroleukin,fibrinogen-like 2,pT49 |
Mouse | HEK293 Cells |
Fibrinogen-like protein 2 (FGL2) is a member of the fibrinogen-like protein family and possesses important regulatory functions in both innate and adaptive immune responses. FGL2 is overexpressed in glioma, and its expression level is negatively associated with the prognosis of glioma patients. FGL2 Protein, Mouse, Recombinant (His & Avi, Flag), Biotinylated is expressed in HEK293 mammalian cells with N-His-Avi and N-Flag tag. The predicted molecular weight is 31.48 kDa and the accession number ... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMID-0229 |
Cortisol-1,2-d2
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Cortisol-1,2-d2 是 Cortisol 的氘代化合物。Cortisol 的 CAS 号为 50-23-7。Hydrocortisone 是肾上腺皮质分泌的糖皮质激素。 | |||
T71206 |
Tiagabine-d6 hydrochloride
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Tiagabine-d6 is intended for use as an internal standard for the quantification of tiagabine by GC- or LC-MS. Tiagabine is an inhibitor of GABA transporter 1. It inhibits seizures induced by DMCM in mice. Tiagabine reduces allodynia in a rodent model of neuropathic pain when used at a dose of 72.8 µmol/kg, and it acts synergistically with gabapentin to delay pain responses in mice in the hot plate test. Formulations containing tiagabine have been used as adjunctive therapies in the treatment of ... | |||
TMIJ-0193 |
Hydrocortisone-d4
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Hydrocortisone-d4 是 Hydrocortisone 的氘代化合物。Hydrocortisone 的 CAS 号为 50-23-7。Hydrocortisone 是肾上腺皮质分泌的糖皮质激素。 | |||
TMIJ-0162 |
Dexamethasone-d4
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Dexamethasone-d4 是 Dexamethasone 的氘代化合物。Dexamethasone 的 CAS 号为 50-02-2。Dexamethasone是一种糖皮质激素受体激动剂和一种 IL 受体调节剂。在脂多糖诱导的巨噬细胞炎症反应中,它抑制含有炎性 microRNA-155 的外泌体的产生。 | |||
T71065 |
Quinapril-d5
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Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con... | |||
T71205 |
Fosinopril-d7 sodium salt
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Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congesti... | |||
T70394 |
Deucravacitinib HCl
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Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional resp... | |||
TMIJ-0518 |
L-Kynurenine-d4-1
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L-Kynurenine-d4-1 是 L-Kynurenine 的氘代化合物。L-Kynurenine 的 CAS 号为 2922-83-0。L-Kynurenine是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
TMID-0071 |
L-Kynurenine-d4
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L-Kynurenine-d4 是 L-Kynurenine 的氘代化合物。L-Kynurenine 的 CAS 号为 2922-83-0。L-Kynurenine是L-色氨酸的代谢物,是芳香烃受体激动剂,可抑制同种异体 T 细胞增殖并增加恶性 U87 神经胶质瘤细胞侵入胶原基质。 | |||
TMIH-0046 |
3-Indoleacrylic acid-d4
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3-Indoleacrylic acid-d4 是 3-Indoleacrylic acid 的氘代化合物。3-Indoleacrylic acid 的 CAS 号为 1204-06-4。3-Indoleacrylic acid是由链球菌属产生的色氨酸的代谢产物。3-Indoleacrylic acid对肠上皮屏障功能有有益作用,并减轻免疫细胞的炎症反应。 | |||
TMID-0294 |
Taurodeoxycholic Acid-d4 Sodium Salt
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Taurodeoxycholic Acid-d4 Sodium Salt 是 Taurodeoxycholic Acid Sodium Salt 的氘代化合物。Taurodeoxycholic Acid Sodium Salt 的 CAS 号为 1180-95-6。Taurodeoxycholate sodium salt 是胆盐相关的阴离子洗涤剂,用于分离膜蛋白,包括线粒体内膜蛋白。它还可以抑制各种炎症反应。 | |||
TMIJ-0272 |
Sarpogrelate-d3 HCl
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Sarpogrelate-d3 HCl 是 Sarpogrelate HCl 的氘代化合物。Sarpogrelate HCl 的 CAS 号为 135159-51-2。Sarpogrelate hydrochloride 是一种选择性5-HT2R拮抗剂,可用于研究与血栓形成有关的血管疾病,对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi值分别为 8.52、6.57 和 7.43。 | |||
TMIJ-0044 |
Carbamazepine-d10
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Carbamazepine-d10 是 Carbamazepine 的氘代化合物。Carbamazepine 的 CAS 号为 298-46-4。Carbamazepine是与三环抗抑郁药化学相关的三环化合物,具有抗惊厥和镇痛特性。它通过减少多突触反应和阻断强直后增强发挥其抗惊厥活性。 它通常用于治疗与三叉神经痛相关的疼痛。 | |||
T38356 |
1,2-Dipalmitoyl-13C-sn-glycero-3-PC
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1,2-Dipalmitoyl-13C-sn-glycero-3-PC is intended for use as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PC by GC- or LC-MS. 1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.1,2,3,4 It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.3 Incorporation... |