Orexin A (Hypocretin-1) (human, rat, mouse) acetate, a hypothalamic neuropeptide with analgesic abilities that penetrates the blood-brain barrier, acts as an OX1R agonist. It promotes the expression of BDNF and TH proteins within SH-SY5Y cells, showing both time- and dose-dependent responses. This compound is valuable for researching appetite control, neurodegenerative conditions, and the modulation of detrimental signaling [1] [2] [3].