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Search Results for " adrenergic "

Targets Recommended: Adrenergic Receptor Adrenergic Receptor

516

抑制剂 & 化合物

43

天然产物

2

化合物库

6

重组蛋白

22

同位素标记化合物

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Cat. No.	Product Name
L2700	肾上腺素能受体化合物库		193 compounds
	193 种特异靶向肾上腺素受体的生物活性小分子化合物的集合，是相关疾病药物筛选的有效工具；
L2610	神经递质受体化合物库		1513 compounds
	1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；

化合物库

肾上腺素能受体化合物库

Cat.No: L2700

Compounds: 193

神经递质受体化合物库

Cat.No: L2610

Compounds: 1513

Cat. No.	Product Name	Target	Signaling Pathways
T37906	Dibenamine hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Dibenamine hydrochloride 是竞争性的、不可逆的肾上腺素能阻断剂，可以修饰肾上腺素的药理作用。它对小鼠体内肾上腺素的破坏率显著增加。
T13016	SR59230A	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	SR59230A 是可透过血脑屏障的、选择性的 β3-肾上腺素能受体拮抗剂，对 β3，β1 和 β2 受体的 IC50分别为 40、408 和 648 nM。
T7065	Tizanidine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tizanidine 是一种 α2-肾上腺素受体激动剂，能够抑制神经递质从CNS 去甲肾上腺素激活的神经元中释放。
T7045	Clonidine Nexiclon,Catapres,Kapvay,可乐定	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Clonidine (Kapvay) 是 alpha2 肾上腺素能激动剂。
T7160	Lofexidine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Lofexidine 是一种选择性α2 受体激动剂，常用于缓解海洛因和其他阿片类戒断的躯体症状。
T40622	Mapenterol hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Mapenterol hydrochloride 是 β2 肾上腺素受体激动剂。
T8348	Phentolamine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phentolamine 是一种 alpha-1 和 alpha-2 选择性肾上腺素能受体拮抗剂。
T8810	Terbutaline	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Terbutaline 是 bambuterol 的活性代谢物，也是β2肾上腺素能受体的短效激动剂，可预防早产及用作支气管扩张剂。
T7728	ACEPROMAZINE MALEATE	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Acepromazine maleate 是一种 α 肾上腺素受体 (alpha-adrenoceptor) 拮抗剂，是一种吩噻嗪类促进安定的试剂。
T0279	Metaraminol tartrate 重酒石酸间羟胺,Metaradrine tartrate,Metaraminol bitartrate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Metaraminol tartrate (Metaradrine tartrate) 是一种 α-肾上腺素能 (α-adrenergic) 激动剂，是一种直接或间接影响肾上腺素受体的拟交感神经胺，其中 α 效应占主导地位，可作为血管加压剂。
T8580	Bupranolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Bupranolol 是竞争性的、口服活性的、非选择性的β-adrenoceptor 拮抗剂，无固有的拟交感神经活性。
T5471	GUANABENZ	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	GUANABENZ 是一种中枢 alpha-2 肾上腺素能激动剂。它的作用机制是作为肾上腺素能 α2-激动剂。
T2524	Dexmedetomidine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Dexmedetomidine 是选择性、具有口服活性的 α2 肾上腺素能受体激动剂，Ki=1.08 nM。它对 α1 肾上腺素受体显示出 1620 倍的选择性。它具有抗焦虑活性，可用于研究促进睡眠和缓解疼痛。
T4983	Isoetharine mesylate salt Isoetarine mesilate,异丙肾上腺素甲磺酸盐	Others; Adrenergic Receptor	GPCR/G Protein; Neuroscience; Others
	Isoetharine mesylate salt (Isoetarine mesilate) 是一种 β-肾上腺素能受体激动剂。它还是能够上调 CYP450 表达的孕烷 X 受体(PXR) 激活剂。
T21640	Talinolol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Talinolol 是一种长效、心脏选择性的 β1-肾上腺素能受体阻滞剂，具有心脏保护和抗高血压作用。它也是众所周知且经常使用的 P-糖蛋白 (P-gp) 活性探针底物。
T1584	Terbutaline Sulfate Terbutaline hemisulfate,硫酸叔丁宁按,硫酸特布他林	Antibacterial; Adrenergic Receptor; Antibiotic	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Terbutaline Sulfate (Terbutaline hemisulfate) 是一种具有口服活性的 β2-肾上腺素能受体激动剂，是班布特罗的活性代谢物。它可研究哮喘。
T10830	CL 316243	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	CL316243 是一种高效的 β3 肾上腺素受体选择性激动剂，EC50 为 3 nM。它是一种有效的脂肪细胞脂解刺激剂，可增加棕色脂肪组织的产热和代谢率，具有治疗肥胖症、糖尿病和急迫性尿失禁的潜力。
T8708	Paroxetine	Serotonin Transporter	Neuroscience
	Paroxetine 是选择性血清素再摄取抑制剂，是苯基哌啶的衍生物。它对于甲肾上腺素摄取抑制功能较弱，但比该位点其他SSRIs 更有效。
T5511	L-765314	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	L-765314 是一种 α1b 肾上腺素能受体的选择性拮抗剂，其在大鼠和人体中的Ki 分别为 5.4 nM 和 2.0 nM。
T1275	Phentolamine mesylate Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phentolamine mesylate (Phentolamine methanesulfonate) 是一种非选择性的、可逆的，具有口服活性的 α1 和 α2 肾上腺素能受体阻滞剂，能够扩张使血管，降低周围血管阻力。它可用于研究嗜铬细胞瘤相关的高血压，心力衰竭和勃起功能障碍。
T12402	Penbutolol sulfate (-)-Terbuclomine,喷布特罗硫酸盐	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Penbutolol sulfate ((-)-Terbuclomine) 是一种非选择性的β阻滞剂，能够结合β-1肾上腺素能受体和β-2肾上腺素能受体 (两种亚型)。Penbutolol 是拟交感神经药，可用于高血压的研究。
T2320	Indacaterol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Indacaterol 是一种超长效β-肾上腺素受体激动剂。
T11318	Dopexamine hydrochloride 盐酸多培沙明,FPL60278AR	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Dopexamine hydrochloride (FPL60278AR) 是β2肾上腺素能受体激动剂。
T12829	Salmeterol 沙美特罗,GR33343X	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Salmeterol (GR33343X) 是一种选择性的人β2肾上腺素受体激动剂。它能够有效刺激 cAMP 积累，作用于 CHO 细胞，对人β2，β1和β3肾上腺素受体的 pEC50分别为 9.6、6.1 和 5.9。
T22406	Prazosin 哌唑嗪,Prazosine,Furazosin,Prazocin	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Prazosin (Prazosine) 是一种 α1 受体阻滞剂，是一种 α1 肾上腺素能受体的反向激动剂，用于治疗高血压。
T6872	L755507	Adrenergic Receptor; CRISPR/Cas9	DNA Damage/DNA Repair; GPCR/G Protein; Neuroscience
	L755507 是一种有效的选择性β3-AR 激动剂，IC50值为 35 nM。
T3284	Carazolol Conducton,Suacron,咔唑心安	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Carazolol (Suacron) 是高效的 β1/β2 肾上腺素受体拮抗剂，也是高效 β3肾上腺素受体选择性激动剂，可用于高血压的研究。
T22316	Doxazosin UK 33274,多沙唑嗪	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Doxazosin (UK 33274) 是选择性的拮抗突触后的α1肾上腺素受体。
T8358	Fenoterol	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Fenoterol 是一种拟交感神经剂，是一种选择性的，具有口服活性 β2-肾上腺素受体 (β2-adrenoceptor) 激动剂，是一种有效的支气管扩张剂，可用于一种与哮喘、支气管炎和其他阻塞性气道疾病相关的支气管痉挛。
T6641	Rilmenidine Phosphate	Apoptosis; Adrenergic Receptor; Autophagy; Imidazoline Receptor	Apoptosis; Autophagy; GPCR/G Protein; Neuroscience
	Rilmenidine phosphate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体激动剂。它可调节白血病细胞增殖，刺激促凋亡蛋白 Bax，从而诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。它可通过减少交感神经过度活跃而发挥中枢作用，并通过抑制 Na+/H+反向转运而在肾脏中发挥作用。
T0394	Moxisylyte hydrochloride 莫西赛利盐酸盐,Thymoxamine hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Moxisylyte hydrochloride (Thymoxamine hydrochloride) 是一种 alpha 1-blocker 的拮抗剂，能在不减少血管压力的情况下，扩张大脑血管。
T1012	Acebutolol hydrochloride 盐酸醋丁洛尔,Acebutolol HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Acebutolol hydrochloride (Acebutolol HCl) 是一种 β-肾上腺素受体拮抗剂，用于研究高血压、心绞痛和心律失常。
T17111	Todralazine hydrochloride Ecarazine hydrochloride,盐酸托屈嗪	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Todralazine hydrochloride (Ecarazine hydrochloride) 是一种 β2AR 阻滞剂，具有抗氧化和自由基清除活性。 Todralazine hydrochloride 可用于抗高血压的研究。
T19680	Zotepine	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Zotepine 是一种抗精神病剂，是有效的5-HT2A、5-HT2C、组胺H1、α1-肾上腺素能和多巴胺D2受体拮抗剂，Kd 值分别为 2.6、3.2、3.3、7.3 和 8 nM。它在体内表现出抗抑郁和抗焦虑作用。
T1132	Nicergoline 尼麦角林,Nicergolinum,Nimergoline	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Nicergoline (Nicergolinum) 是一种有效的，选择性的、具有口服活性的α1A-肾上腺素能受体拮抗剂，是一种溴烟碱酸的麦角林衍生物。它具有血管舒张作用，可以改善阿尔茨海默症小鼠的认知功能。
T21957	Guanabenz hydrochloride NE56490	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Guanabenz hydrochloride (NE56490) 是一种具有降血压作用的口服活性 α2-肾上腺素受体激动剂。
T1671	Mirabegron YM178,米拉贝隆	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Mirabegron (YM178) 是选择性的肾上腺素受体激动剂，EC50=22.4 nM。
T15588	Iobenguane sulfate MIBG sulfate	Others	Others
	Iobenguane sulfate (MIBG sulfate) 是一种具有抗肿瘤活性的神经递质去甲肾上腺素的类似物。Iobenguane sulfate 是一种高亲和力的霍乱毒素底物，干扰细胞单核(ADP-核糖基化)。放射性碘代 Iobenguane sulfate 可用于肾上腺肿瘤诊断和肿瘤靶向药物的研究。
T0993	Methoxamine hydrochloride Methoxamine HCl,盐酸甲氧明	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Methoxamine hydrochloride (Methoxamine HCl) 是一种 alpha1 肾上腺素能受体的选择性激动剂。它通过 Prazosin 敏感机制在兔肺动脉显著增加 ATP、ADP 和 AMP 的溢出，但不增加腺苷的溢出。它引起血管收缩和外周血管阻力增加。
T1247	Clonidine hydrochloride Clonidine HCl,Catapres,盐酸可乐定	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Clonidine hydrochloride (Catapres) 是一种α2-adrenoceptor 激动剂，是一种抗高血压药。
T0397	Tetrahydrozoline 四氢唑林,四氢唑啉,Tetryzolin,Tetryzoline	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tetrahydrozoline (Tetryzoline) 是一种咪唑啉的衍生物，是一种 α-肾上腺素能 (α-adrenergic) 激动剂，能引起血管收缩，广泛用于研究鼻充血、结膜充血。
T0154	Nebivolol hydrochloride R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824	Apoptosis; Adrenergic Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。
T6647	Rotigotine- Neupro,N-0923,罗替戈汀,N-0437,SPM 962	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Rotigotine (N-0923) 是多巴胺受体激动剂，是5-HT1A receptor 的部分激动剂，以及α2B-肾上腺素受体的拮抗剂，用于治疗帕金森病和不宁腿综合征。
T7164	Levalbuterol tartrate 左旋沙丁胺醇酒石酸盐,Levosalbutamol tartrate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Levalbuterol tartrate (Levosalbutamol tartrate) 是一种短效的β2肾上腺素受体激动剂，是一种 salbutamol 的 R 型对映体。
T6766	Atipamezole Antisedan,阿替美唑,MPV 1248	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Atipamezole (Antisedan) 是 α2-肾上腺素受体拮抗剂，Ki=1.6 nM。
T1139	Salbutamol Albuterol,沙丁胺醇,AH-3365	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Salbutamol (Albuterol) 是短效的 β2 肾上腺素受体激动剂，用于哮喘和慢性阻塞性肺疾病(COPD) 引发的支气管痉挛的研究。
T6408	Betaxolol Kerlone,SL 75212,Betoptic,倍他洛尔	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Betaxolol (Kerlone) 是 β1 肾上腺素受体阻断剂，可用于研究高血压和青光眼。
T10952	Dabuzalgron 达布扎琼,Ro 115-1240	Apoptosis; Adrenergic Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Dabuzalgron (Ro 115-1240) 是一种口服活性选择性 α-1A 肾上腺素受体激动剂，用于治疗尿失禁。它通过维持线粒体功能来预防多柔比星引起的心脏毒性。
T1050	Prazosin hydrochloride Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress	Potassium Channel; MRP; Adrenergic Receptor; ABC; Autophagy	Autophagy; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Neuroscience
	Prazosin hydrochloride (Vasoflex) 是一种选择性肾上腺素能 α-1 拮抗剂，可降低外周阻力并放松血管平滑肌。它可用于研究高血压和酒精使用障碍。它是一种合成哌嗪衍生物，具有降压抗肾上腺素能特性。它抑制有机阳离子转运蛋白 OCT-1 和 OCT-3，IC50分别为 1.8 和 13 μM 。
T13376	YS-49	RAAS; Akt; PI3K; Adrenergic Receptor	Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Neuroscience; PI3K/Akt/mTOR signaling
	YS-49 是一种PI3K/Akt(RhoA 的下游靶标) 的激活剂，可减少 3-甲基胆碱处理的细胞中 RhoA/PTEN 的激活。它是异喹啉化合物生物碱，因能激活心脏β-adrenoceptors 而具有强烈的正性肌力作用。它能通过诱导血红素加氧酶来抑制血管紧张素 II 刺激 VSMC 细胞的增殖。

化合物

Dibenamine hydrochloride

Cat.No: T37906

Target: Adrenergic Receptor

Cat.No: T13016

Target: Adrenergic Receptor

Cat.No: T7065

Target: Adrenergic Receptor

Cat.No: T7045

Synonym: Nexiclon,Catapres,Kapvay,可乐定

Target: Adrenergic Receptor

Cat.No: T7160

Target: Adrenergic Receptor

Mapenterol hydrochloride

Cat.No: T40622

Target: Adrenergic Receptor

Cat.No: T8348

Target: Adrenergic Receptor

Cat.No: T8810

Target: Adrenergic Receptor

ACEPROMAZINE MALEATE

Cat.No: T7728

Target: Dopamine Receptor

Metaraminol tartrate

Cat.No: T0279

Synonym: 重酒石酸间羟胺,Metaradrine tartrate,Metaraminol bitartrate

Target: Adrenergic Receptor

Cat.No: T8580

Target: Adrenergic Receptor

Cat.No: T5471

Target: Adrenergic Receptor

Dexmedetomidine

Cat.No: T2524

Target: Adrenergic Receptor

Isoetharine mesylate salt

Cat.No: T4983

Synonym: Isoetarine mesilate,异丙肾上腺素甲磺酸盐

Target: Others, Adrenergic Receptor

Cat.No: T21640

Target: Adrenergic Receptor

Terbutaline Sulfate

Cat.No: T1584

Synonym: Terbutaline hemisulfate,硫酸叔丁宁按,硫酸特布他林

Target: Antibacterial, Adrenergic Receptor, Antibiotic

Cat.No: T10830

Target: Adrenergic Receptor

Cat.No: T8708

Target: Serotonin Transporter

Cat.No: T5511

Target: Adrenergic Receptor

Phentolamine mesylate

Cat.No: T1275

Synonym: Phentolamine methanesulfonate,甲磺酸酚妥拉明,Phentolamine mesilate

Target: Adrenergic Receptor

Penbutolol sulfate

Cat.No: T12402

Synonym: (-)-Terbuclomine,喷布特罗硫酸盐

Target: Adrenergic Receptor

Cat.No: T2320

Target: Adrenergic Receptor

Dopexamine hydrochloride

Cat.No: T11318

Synonym: 盐酸多培沙明,FPL60278AR

Target: Adrenergic Receptor

Cat.No: T12829

Synonym: 沙美特罗,GR33343X

Target: Adrenergic Receptor

Cat.No: T22406

Synonym: 哌唑嗪,Prazosine,Furazosin,Prazocin

Target: Adrenergic Receptor

Cat.No: T6872

Target: Adrenergic Receptor, CRISPR/Cas9

Cat.No: T3284

Synonym: Conducton,Suacron,咔唑心安

Target: Adrenergic Receptor

Cat.No: T22316

Synonym: UK 33274,多沙唑嗪

Target: Adrenergic Receptor

Cat.No: T8358

Target: Adrenergic Receptor

Rilmenidine Phosphate

Cat.No: T6641

Target: Apoptosis, Adrenergic Receptor, Autophagy, Imidazoline Receptor

Moxisylyte hydrochloride

Cat.No: T0394

Synonym: 莫西赛利盐酸盐,Thymoxamine hydrochloride

Target: Adrenergic Receptor

Acebutolol hydrochloride

Cat.No: T1012

Synonym: 盐酸醋丁洛尔,Acebutolol HCl

Target: Adrenergic Receptor

Todralazine hydrochloride

Cat.No: T17111

Synonym: Ecarazine hydrochloride,盐酸托屈嗪

Target: Adrenergic Receptor

Cat.No: T19680

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

Cat.No: T1132

Synonym: 尼麦角林,Nicergolinum,Nimergoline

Target: Adrenergic Receptor

Guanabenz hydrochloride

Cat.No: T21957

Synonym: NE56490

Target: Adrenergic Receptor

Cat.No: T1671

Synonym: YM178,米拉贝隆

Target: Adrenergic Receptor

Iobenguane sulfate

Cat.No: T15588

Synonym: MIBG sulfate

Target: Others

Methoxamine hydrochloride

Cat.No: T0993

Synonym: Methoxamine HCl,盐酸甲氧明

Target: Adrenergic Receptor

Clonidine hydrochloride

Cat.No: T1247

Synonym: Clonidine HCl,Catapres,盐酸可乐定

Target: Adrenergic Receptor

Tetrahydrozoline

Cat.No: T0397

Synonym: 四氢唑林,四氢唑啉,Tetryzolin,Tetryzoline

Target: Adrenergic Receptor

Nebivolol hydrochloride

Cat.No: T0154

Synonym: R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824

Target: Apoptosis, Adrenergic Receptor

Cat.No: T6647

Synonym: Neupro,N-0923,罗替戈汀,N-0437,SPM 962

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor

Levalbuterol tartrate

Cat.No: T7164

Synonym: 左旋沙丁胺醇酒石酸盐,Levosalbutamol tartrate

Target: Adrenergic Receptor

Cat.No: T6766

Synonym: Antisedan,阿替美唑,MPV 1248

Target: Adrenergic Receptor

Cat.No: T1139

Synonym: Albuterol,沙丁胺醇,AH-3365

Target: Adrenergic Receptor

Cat.No: T6408

Synonym: Kerlone,SL 75212,Betoptic,倍他洛尔

Target: Adrenergic Receptor

Cat.No: T10952

Synonym: 达布扎琼,Ro 115-1240

Target: Apoptosis, Adrenergic Receptor

Prazosin hydrochloride

Cat.No: T1050

Synonym: Prazosin hydrochloride,哌唑嗪盐酸盐,Prazosin HCl,cp-12299-1,Peripress,Vasoflex,盐酸哌唑嗪,Minipress

Target: Potassium Channel, MRP, Adrenergic Receptor, ABC, Autophagy

Cat.No: T13376

Target: RAAS, Akt, PI3K, Adrenergic Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T1287	Synephrine 辛弗林,Oxedrine	Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Synephrine (Oxedrine) 是来自 Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂，是一种生物碱。它也是一种拟交感神经化合物，能够用于减肥。
T6688	Synephrine hydrochloride 辛弗林盐酸盐,Oxedrine hydrochloride,Synephrine HCl	Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Synephrine hydrochloride (Oxedrine hydrochloride) 是一种来自Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂的生物碱，也是一种拟交感神经化合物，能够用于减肥。
TN1015	Meranzin	Adrenergic Receptor; Immunology/Inflammation related	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Meranzin 是从传统中药 Chaihu-Shugan-San (CSS) 中的生物活性化合物，是从紫茉莉叶中分离出的，能够调节共有的 α2-肾上腺素受体，并参与 AMPA-ERK1/2-BDNF 信号传导。它有潜在的预防动脉粥样硬化和抑郁症合并症。
T6662	Scopine 东莨菪醇,6,7-Epoxytropine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Scopine (6,7-Epoxytropine) 是一种山莨菪碱的代谢物，是一种 α1-肾上腺素受体激动剂，用于治疗急性循环性休克。
T2142	Yohimbine hydrochloride 盐酸育亨宾,Antagonil,Yohimbine HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Yohimbine hydrochloride (Antagonil) 是一种植物生物碱，具有 α-2-肾上腺素能阻断活性。它被用作散瞳药和治疗勃起功能障碍。
T6519	Gramine NSC 16892,芦竹碱,Donaxine	Adiponectin receptor; Reverse Transcriptase; Adrenergic Receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Gramine (Donaxine) 是从芦竹中得到的一种生物碱，是脂联素受体激动剂，对 AdipoR2 和 AdipoR1 的 IC50值分别为 3.2 和 4.2 µM。它也是小鼠和人β2-肾上腺素受体激动剂，具有抗肿瘤、抗炎和抗病毒作用。
T8149	Dobutamine hydrochloride 盐酸多巴酚丁胺,Dobutamine (hydrochloride)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Dobutamine hydrochloride (Dobutamine(hydrochloride)) 是一种合成的儿茶酚胺，可作用于肾上腺素能受体α1-AR、β1-AR 和β2-AR，是一种选择性的 β1-AR 受体激动剂，对 α1-AR 和 β2-AR 作用相对较弱。它能够增加心输出量，矫正低灌注。
T17310	Phenylephrine 去氧肾上腺素,L-Phenylephrine,去氧肾上腺素碱,(R)-(-)-Phenylephrine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phenylephrine ((R)-(-)-Phenylephrine) 是一种选择性的α1-肾上腺素受体激动剂，常用作减充血剂。
TN1465	Cannabigerol	NOS; 5-HT Receptor; ROS	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Cannabigerol 是一种植物大麻素，是一种高亲和力 α2-肾上腺素能受体激动剂、中度亲和力 5-HT1A 受体拮抗剂和低亲和力 CB1/CB2受体拮抗剂。它可降低眼压，有潜力治疗青光眼。
T13655	DL-Norepinephrine hydrochloride 去甲肾上腺素盐酸盐,Lys,DL-lysine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	DL-Norepinephrine hydrochloride (DL-lysine) 是一种靶向α1 adrenoceptor 和β1 adrenoceptor 的神经递质，可降低心内膜下氧分压。它是一种模拟内源性去甲肾上腺素的拟交感神经作用的合成苯乙胺。
T7044	Norepinephrine 去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol	MMP; Endogenous Metabolite; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Neuroscience; Proteases/Proteasome
	Norepinephrine (Levophed) 属于生物碱类天然产物，是一种神经递质，一种肾上腺素能受体 (AR) 的激动剂，对 α1、α2 和 β1 AR 具有激活活性。Norepinephrine 被用作抗休克的血管活性剂。
T0076	Paliperidone 9-羟基利培酮,帕潘立酮,9-hydroxyrisperidone	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Paliperidone (9-hydroxyrisperidone) 是 Risperidone 的主要活性代谢产物，是多巴胺 D2 拮抗剂和5-HT2A 拮抗剂。它用作非典型抗精神病药，用于精神分裂症的急性及维持治疗。它对α1和α2肾上腺素能受体和 H1组胺能受体也有拮抗作用。
T0505	Methyldopa L-(-)-α-Methyldopa,MK-351,甲基多巴	Dopamine Receptor; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	L-(-)-α-Methyldopa (MK-351) 是一种前药，在中枢神经系统中被代谢成 α-Methylepinephrine。它是 α-肾上腺素能激动剂，对 α2- adrenergic receptors 有选择性。
T0453	Phenylephrine hydrochloride NCI-c55641,Phenylephrine HCl,盐酸去氧肾上腺素,(R)-(-)-Phenylephrine hydrochloride	Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Phenylephrine hydrochloride (NCI-c55641) 是选择性的α1-肾上腺素能受体激动剂，对α1A，α1B 和α1D 受体的pKis 分为4.70，4.87和5.86。
T3158	Harmane Loturine,Harman,Aribine,哈尔满碱	Adrenergic Receptor; Monoamine Oxidase; Imidazoline Receptor	GPCR/G Protein; Neuroscience
	Harmane (Loturine) 是一种在咖啡和烟草烟雾中发现的 β-咔啉生物碱，是有效的神经毒素，可引起严重的动作震颤和精神病学表现。它还是选择性的单胺氧化酶抑制剂，具有致突变作用，对 MAO A/B 的 IC50值分别为 0.5 和 5 μM。
TCS2185	Yohimbine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Yohimbine 是一种有效的、相对非选择性的α2 - 肾上腺素能受体拮抗剂，IC50=0.6μM。
T2889	Isoferulic acid Isoferulate,Hesperetic acid,3-Hydroxy-4-methoxycinnamic acid,Hesperetate,异阿魏酸	Influenza Virus; Adrenergic Receptor	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Isoferulic acid (Hesperetate) 是一种肉桂酸衍生物，有抗糖尿病活性和抗流感病毒活性。它能结合并激活 α1-肾上腺素能受体，增强 β-内啡肽的分泌并增加体外葡萄糖的使用。
T5S2059	Glaucine	Calcium Channel; Dopamine Receptor; Influenza Virus; Adrenergic Receptor; PDE	GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	Glaucine 是从海罂粟中分离的一种生物碱，具有镇咳、抗炎和支气管扩张作用。它是具有口服活性的磷酸二酯酶 4 选择性抑制剂。它还是非选择性的 α-肾上腺素受体拮抗剂，具有抗氧化和抗病毒活性。
T0469	Octopamine hydrochloride 章鱼胺盐酸盐,(±)-p-Octopamine hydrochlorid,(+,-)-Octopamine HCl,章胺盐酸盐	Dopamine Receptor; Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) 是一种与去甲肾上腺素结构相关的生物单胺类物质，在无脊椎动物中起着神经调节剂、神经激素和神经递质的作用。它对转染人 alpha2-肾上腺素受体(ARs)的中国仓鼠卵巢细胞 α2-ARs 有刺激作用。它提高糖原分解、糖酵解、糖异生、摄氧量和门脉灌注压。
T3232	Higenamine hydrochloride Higenamine HCl,Demethylcoclaurine hydrochloride,盐酸去甲乌头碱,norcoclaurine HCl,(+-)-Demethylcoclaurine hydrochloride,Higenamine Hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Higenamine hydrochloride (norcoclaurine HCl) 是一种 β2-AR 激动剂，是用于心力衰竭相关研究的中药乌头的关键成分，具有抗凋亡活性。
T1064	Norepinephrine bitartrate monohydrate 酒石酸去甲肾上腺素,Levophed,Noradrenaline bitartrate monohydrate,降肾上腺素	Endogenous Metabolite; Adrenergic Receptor; Autophagy	Autophagy; GPCR/G Protein; Metabolism; Neuroscience
	Norepinephrine bitartrate monohydrate (Levophed) 是一种β1-选择性的肾上腺素能受体激动剂，EC50为 5.37 μM。
T7056	Dronedarone 决奈达隆,SR 33589	P450; Potassium Channel; Calcium Channel; Sodium Channel; Adrenergic Receptor; AChR; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
	Dronedarone (SR 33589) 是一种胺碘酮类似物，对治疗心房颤动可能有效。它是CYP3A4的底物和中度抑制剂。它是多种离子电流的有效阻滞剂，通过非竞争性结合到肾上腺素能受体显示出抗肾上腺素能的效果。
T4429	Rauwolscine hydrochloride Corynanthidine hydrochloride,盐酸育亨宾碱,萝芙素盐酸盐,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Rauwolscine hydrochloride (Isoyohimbine hydrochloride) 是一种高选择性的 α2 adrenergic 受体拮抗剂，Ki=12 nM。
T1680	Tolazoline hydrochloride Imidaline hydrochloride,苯甲唑啉盐酸盐,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride)	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Tolazoline hydrochloride (NSC35110(hydrochloride)) 是一种 α 肾上腺素受体抑制剂。
T3095	Tyramine 4-hydroxyphenethylamine,酪胺,para-tyramine,p-Tyramine,mydrial,Tocosine,Uteramine	MAO; Endogenous Metabolite	Metabolism; Neuroscience
	Tyramine (Uteramine) 是天然存在于体内或某些食物中的氨基酸。Tyramine 有助于调节血压。
T21066	Norepinephrine bitartrate salt	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Norepinephrine bitartrate salt 是一种肾上腺素能神经递质。
T8304	Anisodamine Hydrobromide 6-Hydroxyhyoscyamine,氢溴酸山莨菪碱	Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) 是来自颠茄的一种生物碱，具有抗氧化、抗炎活性。它也是一种非亚型的选择性毒蕈碱和烟碱类胆碱受体拮抗剂。
T0970	Racanisodamine 山莨菪碱,Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine,消旋山莨菪碱	Adrenergic Receptor; AChR	GPCR/G Protein; Neuroscience
	Racanisodamine (7β-Hydroxyhyoscyamine) 是 anisodamine 的消旋体，是非选择性的毒蕈碱拮抗剂，是近视控制滴眼液的有效成分。
T6S0627	Mesaconitine 新乌碱,新乌头碱；中乌头碱	TNF	Apoptosis
	Mesaconitine 是乌头属植物的一种主要活性成分，通过循环 AMP 和刺激中枢 β-肾上腺素能系统具有镇痛活性，还有抗炎活性。
T0783	Mianserin hydrochloride Mianserin HCl,Org GB 94,盐酸米安色林,ORG GB-94 HCl	Dopamine Receptor; 5-HT Receptor; Opioid Receptor; Adrenergic Receptor; Histamine Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mianserin hydrochloride (Org GB 94) 是一种有抗抑郁活性的 H1 受体反向激动剂。
TN7129	Methyl maslinate 马斯里酸甲酯,Maslinic acid methyl ester,Crategolic acid methyl ester	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Methyl maslinate (Maslinic acid methyl ester) 是一种具有强心和抗心律失常特性的 β-肾上腺素受体拮抗剂。Methyl maslinate 可用于高血压研究。
T1644	Dopamine hydrochloride 盐酸多巴胺,Dopamine HCl,ASL279	Ferroptosis; Dopamine Receptor; 5-HT Receptor; Endogenous Metabolite	Apoptosis; GPCR/G Protein; Metabolism; Neuroscience
	Dopamine hydrochloride (ASL279) 是在脑黑质、脑腹侧被盖区和下丘脑中产生的一种天然儿茶酚胺，由二羟基苯丙氨酸脱羧形成，是去甲肾上腺素和肾上腺素的前体。它通过 D2 多巴胺受体来诱导 VEGFR2 的内吞作用，有促进血管生成活性。
T0266	Quinidine hydrochloride monohydrate 奎宁树,奎尼丁盐酸盐一水合物,奎尼丁盐酸盐,Quinidine hydrochloride	Potassium Channel; Sodium Channel; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	Quinidine hydrochloride monohydrate 是一种抗心律失常剂，也是 K+通道 (K+channel) 的有效阻断剂，其IC50值为 19.9 μM。它是一种有效且选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也可用作疟疾的研究。
T5S1177	Aloin B Isobarbaloin,芦荟苷B,芦荟素B	Others	Others
	Aloin B (Isobarbaloin) 是一种芦荟素的异构体。其中芦荟素是芦荟中的具生理活性蒽醌化合物。
TN4882	Quinine HCl 奎宁树	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Quinine HCl produces alpha-adrenergic blockade. Quinine modifies catecholamine- and calcium-induced myocardial contractile force responses.
T75425	Synephrine hemitartrate	Others	Others
	Synephrine (Oxedrine) hemitartrate，一种生物碱，是一种来自Citrus aurantium 的α-adrenergic 和β-adrenergic 激动剂。Synephrine hemitartrate 是一种拟交感神经化合物，可用于减肥。
T19910	Corynanthine NSC-407306,NSC407306,NSC 407306	Others	Others
	Corynanthe is a plant alkaloid. Corynanthe also has an alpha-2-adrenergic blocking activity.
T11937	m-Tyramine	Others	Others
	m-Tyramine has effects on the adrenergic and dopaminergic receptor.m-Tyramine is an endogenous trace amine neuromodulator.
T2S1727	Lycorenine	Antifection	Microbiology/Virology
	Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph
TN1797	Isorhoifolin	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Isorhoifolin and vicenin II are main compounds of ethyl acetate fraction (EAcF) obtained from Erythrina velutina leaves, EAcF increases the cardiac contractile force by increasing the l-type calcium current and activating the adrenergic receptor pathway.
TN7042	N-methyltyramine	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	N-methyltyramine 是一种从豆科植物大叶相思中分离出的生物碱，是一种 α2-肾上腺素受体拮抗剂，通过酶促肾上腺素合成调节肾上腺素能受体，可用于研究肠道疾病。
T60245	Norepinephrine hydrochloride	Others	Others
	Norepinephrine hydrochloride (Levarterenol hydrochloride) 是一种β1选择性的肾上腺素受体激动剂，EC50值为 5.37 μM。
TN2001	Oblongine	Others	Others
	Oblongine chloride may have potential haemodynamic effects, it can cause a dose-dependent reduction of systolic and diastolic blood pressure, and that these effects are not mediated by α²-adrenergic receptor stimulation.

天然产物

Cat.No: T1287

Synonym: 辛弗林,Oxedrine

Target: Endogenous Metabolite, Adrenergic Receptor

Synephrine hydrochloride

Cat.No: T6688

Synonym: 辛弗林盐酸盐,Oxedrine hydrochloride,Synephrine HCl

Target: Endogenous Metabolite, Adrenergic Receptor

Cat.No: TN1015

Target: Adrenergic Receptor, Immunology/Inflammation related

Cat.No: T6662

Synonym: 东莨菪醇,6,7-Epoxytropine

Target: Adrenergic Receptor

Yohimbine hydrochloride

Cat.No: T2142

Synonym: 盐酸育亨宾,Antagonil,Yohimbine HCl

Target: Adrenergic Receptor

Cat.No: T6519

Synonym: NSC 16892,芦竹碱,Donaxine

Target: Adiponectin receptor, Reverse Transcriptase, Adrenergic Receptor

Dobutamine hydrochloride

Cat.No: T8149

Synonym: 盐酸多巴酚丁胺,Dobutamine (hydrochloride)

Target: Adrenergic Receptor

Cat.No: T17310

Synonym: 去氧肾上腺素,L-Phenylephrine,去氧肾上腺素碱,(R)-(-)-Phenylephrine

Target: Adrenergic Receptor

Cat.No: TN1465

Target: NOS, 5-HT Receptor, ROS

DL-Norepinephrine hydrochloride

Cat.No: T13655

Synonym: 去甲肾上腺素盐酸盐,Lys,DL-lysine

Target: Adrenergic Receptor

Cat.No: T7044

Synonym: 去甲肾上腺素,Levophed,Levonoradrenaline,Aktamin,Nor-Epirenan,Levonor,Arterenol

Target: MMP, Endogenous Metabolite, Adrenergic Receptor, Autophagy

Cat.No: T0076

Synonym: 9-羟基利培酮,帕潘立酮,9-hydroxyrisperidone

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

Cat.No: T0505

Synonym: L-(-)-α-Methyldopa,MK-351,甲基多巴

Target: Dopamine Receptor, Adrenergic Receptor

Phenylephrine hydrochloride

Cat.No: T0453

Synonym: NCI-c55641,Phenylephrine HCl,盐酸去氧肾上腺素,(R)-(-)-Phenylephrine hydrochloride

Target: Endogenous Metabolite, Adrenergic Receptor

Cat.No: T3158

Synonym: Loturine,Harman,Aribine,哈尔满碱

Target: Adrenergic Receptor, Monoamine Oxidase, Imidazoline Receptor

Cat.No: TCS2185

Target: Adrenergic Receptor

Isoferulic acid

Cat.No: T2889

Synonym: Isoferulate,Hesperetic acid,3-Hydroxy-4-methoxycinnamic acid,Hesperetate,异阿魏酸

Target: Influenza Virus, Adrenergic Receptor

Cat.No: T5S2059

Target: Calcium Channel, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, PDE

Octopamine hydrochloride

Cat.No: T0469

Synonym: 章鱼胺盐酸盐,(±)-p-Octopamine hydrochlorid,(+,-)-Octopamine HCl,章胺盐酸盐

Target: Dopamine Receptor, Endogenous Metabolite, Adrenergic Receptor

Higenamine hydrochloride

Cat.No: T3232

Synonym: Higenamine HCl,Demethylcoclaurine hydrochloride,盐酸去甲乌头碱,norcoclaurine HCl,(+-)-Demethylcoclaurine hydrochloride,Higenamine Hydrochloride

Target: Adrenergic Receptor

Norepinephrine bitartrate monohydrate

Cat.No: T1064

Synonym: 酒石酸去甲肾上腺素,Levophed,Noradrenaline bitartrate monohydrate,降肾上腺素

Target: Endogenous Metabolite, Adrenergic Receptor, Autophagy

Cat.No: T7056

Synonym: 决奈达隆,SR 33589

Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy

Rauwolscine hydrochloride

Cat.No: T4429

Synonym: Corynanthidine hydrochloride,盐酸育亨宾碱,萝芙素盐酸盐,α-Yohimbine hydrochloride,Isoyohimbine hydrochloride

Target: Adrenergic Receptor

Tolazoline hydrochloride

Cat.No: T1680

Synonym: Imidaline hydrochloride,苯甲唑啉盐酸盐,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride)

Target: Adrenergic Receptor

Cat.No: T3095

Synonym: 4-hydroxyphenethylamine,酪胺,para-tyramine,p-Tyramine,mydrial,Tocosine,Uteramine

Target: MAO, Endogenous Metabolite

Norepinephrine bitartrate salt

Cat.No: T21066

Target: Adrenergic Receptor

Anisodamine Hydrobromide

Cat.No: T8304

Synonym: 6-Hydroxyhyoscyamine,氢溴酸山莨菪碱

Target: Adrenergic Receptor, AChR

Cat.No: T0970

Synonym: 山莨菪碱,Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine,消旋山莨菪碱

Target: Adrenergic Receptor, AChR

Cat.No: T6S0627

Synonym: 新乌碱,新乌头碱；中乌头碱

Target: TNF

Mianserin hydrochloride

Cat.No: T0783

Synonym: Mianserin HCl,Org GB 94,盐酸米安色林,ORG GB-94 HCl

Target: Dopamine Receptor, 5-HT Receptor, Opioid Receptor, Adrenergic Receptor, Histamine Receptor

Methyl maslinate

Cat.No: TN7129

Synonym: 马斯里酸甲酯,Maslinic acid methyl ester,Crategolic acid methyl ester

Target: Adrenergic Receptor

Dopamine hydrochloride

Cat.No: T1644

Synonym: 盐酸多巴胺,Dopamine HCl,ASL279

Target: Ferroptosis, Dopamine Receptor, 5-HT Receptor, Endogenous Metabolite

Quinidine hydrochloride monohydrate

Cat.No: T0266

Synonym: 奎宁树,奎尼丁盐酸盐一水合物,奎尼丁盐酸盐,Quinidine hydrochloride

Target: Potassium Channel, Sodium Channel, Parasite

Cat.No: T5S1177

Synonym: Isobarbaloin,芦荟苷B,芦荟素B

Target: Others

Cat.No: TN4882

Synonym: 奎宁树

Target: Adrenergic Receptor

Synephrine hemitartrate

Cat.No: T75425

Target: Others

Cat.No: T19910

Synonym: NSC-407306,NSC407306,NSC 407306

Target: Others

Cat.No: T11937

Target: Others

Cat.No: T2S1727

Target: Antifection

Cat.No: TN1797

Target: Adrenergic Receptor

N-methyltyramine

Cat.No: TN7042

Target: Adrenergic Receptor

Norepinephrine hydrochloride

Cat.No: T60245

Target: Others

Cat.No: TN2001

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04562	GRK2 Protein, Human, Recombinant (His & GST) β,adrenergic, beta, receptor kinase 1	Human	Baculovirus Insect Cells
	G-protein coupled receptor kinase 2 (GRK2), also referred as Adrenergic, beta, receptor kinase 1 (ADRBK1), is a ubiquitous member of the G protein-coupled receptor kinase (GRK) family that appears to play a central, integrative role in signal transduction cascades. GRK2 can phosphorylate a growing number of non-GPCR substrates and associate with a variety of proteins related to signal transduction, thus suggesting that this kinase could also have diverse 'effector' functions. GRK2 has been repor...
TMPH-02540	GRK2 Protein, Mouse, Recombinant (His & SUMO) Beta-adrenergic receptor kinase 1,Grk2,G-protein-co...	Mouse	E. coli
	Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and...
TMPJ-00983	ARRB1 Protein, Human, Recombinant (His) Arrestin β-1,β-Arrestin-1,Beta-Arrestin-1,ARR1,ARRB1,Arresti...	Human	E. coli
	β-Arrestin-1 (ARRB1) is a cytoplasmic protein that belongs to the arrestin family. ARRB1 is expressed at high levels in peripheral blood leukocytes and the central nervous system. ARRB1 regulates agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. ARRB1 acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. ARRB1 is believed to play a major role in r...
TMPH-02693	GNAI2 Protein, Mouse, Recombinant (His) Guanine nucleotide-binding protein G(i) subunit alpha-2,Gnai...	Mouse	E. coli
	Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
TMPH-01250	MAP2K3 Protein, Human, Recombinant (His & SUMO) MAP2K3,MAPK/ERK kinase 3,Dual specificity mitogen-activated ...	Human	E. coli
	Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. MAP2K3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.3 kDa and the accession numbe...
TMPH-01422	GNAS Protein, Human, Recombinant (His & SUMO) Guanine nucleotide-binding protein G(s) subunit alpha isofor...	Human	E. coli
	Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. GNAS Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6...

重组蛋白

GRK2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04562

Species: Human

Expression System: Baculovirus Insect Cells

GRK2 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02540

Species: Mouse

Expression System: E. coli

ARRB1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00983

Species: Human

Expression System: E. coli

GNAI2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02693

Species: Mouse

Expression System: E. coli

MAP2K3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01250

Species: Human

Expression System: E. coli

GNAS Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01422

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T12550	Propranolol-d7 hydrochloride Propranolol D7 hydrochloride	Others	Others
	Propranolol D7 hydrochloride is a deuterium labeled Propranolol hydrochloride. Propranolol hydrochloride is a nonselective antagonist of β-adrenergic receptor (βAR).
TMID-0236	Bisoprolol-d7 hemifumarate
	Bisoprolol-d7 hemifumarate 是 Bisoprolol hemifumarate 的氘代化合物。Bisoprolol hemifumarate 的 CAS 号为 104344-23-2。Bisoprolol hemifumarate 是一种 β1 肾上腺素受体阻断剂。
T10229	Acebutolol D7	Others	Others
	Acebutolol D7 is a deuterium-labeled Acebutolol. Acebutolol is a selective antagonist of the β1 adrenergic receptor used in the treatment of angina pectoris, hypertension, and cardiac arrhythmias.
TMIJ-0175	Bisoprolol-d5 Hemifumarate
	Bisoprolol-d5 Hemifumarate 是 Bisoprolol Hemifumarate 的氘代化合物。Bisoprolol Hemifumarate 的 CAS 号为 104344-23-2。Bisoprolol hemifumarate 是一种 β1 肾上腺素受体阻断剂。
T19297	Doxazosin D8 UK 33274 D8	Others	Others
	Doxazosin D8 (UK 33274 D8) is a deuterium labeled Doxazosin (UK 33274).Doxazosin, a quinazoline derivative, selectively antagonizes postsynaptic AP1 adrenergic receptor.
TMID-0197	Metoprolol-d6
	Metoprolol-d6 是 Metoprolol 的氘代化合物。Metoprolol 的 CAS 号为 51384-51-1。
T10149	4-Hydroxypropranolol-d7 hydrochloride (±)-4-hydroxy Propranolol D7 hydrochloride,4-Hydroxypropranolol D7 hydrochloride	Others	Others
	4-Hydroxypropranolol D7 hydrochloride is deuterium-labeled 4-Hydroxypropranolol hydrochloride. 4-Hydroxypropranolol hydrochloride is an active metabolite of Propranolol, with a potency comparable to Propranolol. It inhibits β1- and β2-adrenergic receptors
TMIH-0453	Procaterol-d7 (Rac)-Procaterol-d7
	Procaterol-d7 是 Procaterol 的氘代化合物。Procaterol 的 CAS 号为 81262-93-3。Procaterol hydrochloride用于治疗哮喘的短效β2-肾上腺素受体激动剂。
TMIH-0417	Oxprenolol hydrochloride-d7
	Oxprenolol hydrochloride-d7 是 Oxprenolol hydrochloride 的氘代化合物。Oxprenolol hydrochloride 的 CAS 号为 6452-73-9。Oxprenolol hydrochloride 是一种有效的、具有口服活性的β-肾上腺素受体拮抗剂，Ki为 7.10 nM。
TMIJ-0317	Nadolol-d9 (Mixture of Diastereomers)
	Nadolol-d9 (Mixture of Diastereomers) 是 Nadolol 的氘代化合物。Nadolol 的 CAS 号为 42200-33-9。Nadolol 是一种有机阴离子转运多肽 1A2 (OATP1A2) 的底物，是一种非选择性的、具有口服活性的 β-肾上腺素受体 (β-adrenergic receptors) 阻滞剂，可用于高血压，心绞痛和血管性头痛的研究。
TMIH-0512	Salbutamol-d3
	Salbutamol-d3 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂，用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。
T35591	Guanfacine-13C,15N3 Guanfacine-13C,15N3
	Guanfacine-13C,15N3is intended for us as an internal standard for the quantification of guanfacine by GC- or LC-MS. Guanfacine is an α2-adrenergic receptor (α2-AR) agonist with Kivalues of 93, 1,380, and 3,890 nM for α2A-, α2B-, and α2C-ARs, respectively, in a radioligand binding assay.1It has EC50values of 52, 288, and 602 nM for α2A-, α2B-, and α2C-ARs, respectively, for stimulated [35S]GTPγS binding. It also binds to imidazoline receptor 1 (Ki= 19 nM in a radioligand binding assay).2Guanfacin...
TMID-0233	Salbutamol-d9
	Salbutamol-d9 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂，用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。
TMID-0189	Mianserin-d3 HCl
	Mianserin-d3 HCl 是 Mianserin HCl 的氘代化合物。Mianserin HCl 的 CAS 号为 21535-47-7。Mianserin hydrochloride 是一种有抗抑郁活性的 H1 受体反向激动剂。
TMID-0126	Clonidine-d4 Hydrochloride
	Clonidine-d4 Hydrochloride 是 Clonidine Hydrochloride 的氘代化合物。Clonidine Hydrochloride 的 CAS 号为 4205-91-8。Clonidine hydrochloride 是一种α2-adrenoceptor激动剂，是一种抗高血压药。
TMID-0245	Pindolol-d7
	Pindolol-d7 是 Pindolol 的氘代化合物。Pindolol 的 CAS 号为 13523-86-9。Pindolol 是一种非选择性β-阻断剂，局部的β-肾上腺素能受体激动剂活性，也作为5-HT1A受体部分拮抗剂，Ki为33nM。它是非心脏选择性的，具有内在的拟交感神经作用。
TMIJ-0426	Celiprolol-d9 Hydrochloride
	Celiprolol-d9 Hydrochloride 是 Celiprolol Hydrochloride 的氘代化合物。Celiprolol Hydrochloride 的 CAS 号为 57470-78-7。Celiprolol hydrochloride 是一种选择性肾上腺素受体调节剂，是一种选择性的和具有口服活性的β1肾上腺素受体拮抗剂，具有部分β2激动剂活性，具有降压和抗心绞痛的作用。
TMIJ-0494	Higenamine-d4 HCl
	Higenamine-d4 HCl 是 Higenamine HCl 的氘代化合物。Higenamine HCl 的 CAS 号为 11041-94-4。Higenamine hydrochloride 是一种 β2-AR 激动剂，是用于心力衰竭相关研究的中药乌头的关键成分，具有抗凋亡活性。
T69598	Isoproterenol-d7 HCl
	Isoproterenol-d7 is intended for use as an internal standard for the quantification of isoproterenol by GC- or LC-MS. Isoproterenol is an agonist of β1- and β2-adrenergic receptors (β1- and β2-ARs; Kis = 224 and 458 nM, respectively). It is selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM). Isoproterenol inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM). In vivo, isoproterenol (0.33 mg/kg) decreases blood pressure and increases water intake in nephrectom...
TMIH-0314	Lurasidone-d8 HCl
	Lurasidone-d8 HCl 是 Lurasidone HCl 的氘代化合物。Lurasidone HCl 的 CAS 号为 367514-88-3。Lurasidone hydrochloride 是多巴胺 D2和5-HT7的拮抗剂，IC50值分别为 1.68 和 0.495 nM，用于治疗精神分裂症和双相情感障碍。它也是5-HT1A受体的部分激动剂，IC50值为 6.75 nM。
T70960	Maprotiline-d3 hydrochloride
	Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in r...
TMID-0280	Atehexal-d7
	Atehexal-d7 是 Atehexal 的氘代化合物。Atehexal 的 CAS 号为 29122-68-7。Atenolol 是一种心脏选择性的 β1 肾上腺素能受体 (β1-adrenergic receptor) 阻断剂，可用于研究高血压和心绞痛。它在豚鼠左心室膜β1肾上腺素能受体处的Ki为 697 nM。

同位素标记化合物

Propranolol-d7 hydrochloride

Cat.No: T12550

Synonym: Propranolol D7 hydrochloride

Target: Others

Bisoprolol-d7 hemifumarate

Cat.No: TMID-0236

Cat.No: T10229

Target: Others

Bisoprolol-d5 Hemifumarate

Cat.No: TMIJ-0175

Cat.No: T19297

Synonym: UK 33274 D8

Target: Others

Cat.No: TMID-0197

4-Hydroxypropranolol-d7 hydrochloride

Cat.No: T10149

Synonym: (±)-4-hydroxy Propranolol D7 hydrochloride,4-Hydroxypropranolol D7 hydrochloride

Target: Others

Cat.No: TMIH-0453

Synonym: (Rac)-Procaterol-d7

Oxprenolol hydrochloride-d7

Cat.No: TMIH-0417

Nadolol-d9 (Mixture of Diastereomers)

Cat.No: TMIJ-0317

Cat.No: TMIH-0512

Guanfacine-13C,15N3

Cat.No: T35591

Synonym: Guanfacine-13C,15N3

Cat.No: TMID-0233

Mianserin-d3 HCl

Cat.No: TMID-0189

Clonidine-d4 Hydrochloride

Cat.No: TMID-0126

Cat.No: TMID-0245

Celiprolol-d9 Hydrochloride

Cat.No: TMIJ-0426

Higenamine-d4 HCl

Cat.No: TMIJ-0494

Isoproterenol-d7 HCl

Cat.No: T69598

Lurasidone-d8 HCl

Cat.No: TMIH-0314

Maprotiline-d3 hydrochloride

Cat.No: T70960

Cat.No: TMID-0280

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