Conopeptide rho-TIA, a peptide from Conus tulipa venom, acts as a selective, noncompetitive inhibitor at the human α1B-Adrenergic Receptor and as a competitive inhibitor at the α1A and α1D-Adrenergic Receptors. Binding to these subtypes, conopeptide rho-TIA may inform the creation of new α1-Adrenergic Receptor subtype-selective drugs [1].

Conopeptide rho-TIA（100 nM, 24-48小时）与人体α1B-Adrenergic受体产生非竞争性、可逆的相互作用，暗示这种化合物可能作为一个异位抑制剂 [1]。此外，Conopeptide rho-TIA（30 nM, 2小时）对于α1B-Adrenergic受体也表现出非竞争性抑制作用，在α1A-Adrenergic和α1D-Adrenergic受体亚型上则呈现竞争性抑制 [1]。同时，Conopeptide rho-TIA（10 μM, 单次处理）能够抑制由去甲肾上腺素激发的α1肾上腺素受体介导的细胞内Ca2+浓度升高，而对α2肾上腺素受体介导的突触前反应无影响 [2]。