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Search Results for " g2/m phase "

Targets Recommended: Microtubule Associated

140

抑制剂 & 化合物

12

天然产物

1

化合物库

8

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L8100	细胞周期化合物库		677 compounds
	677 种细胞周期相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

细胞周期化合物库

Cat.No: L8100

Compounds: 677

Cat. No.	Product Name	Target	Signaling Pathways
T1753	D-64131	Microtubule Associated	Cytoskeletal Signaling
	D64131 是一种微管蛋白聚合抑制剂，IC50 值为 0.53 μM。它具有抗丝分裂活性，可用于癌症研究。
T22260	Aminopurvalanol A	CDK	Cell Cycle/Checkpoint
	Aminopurvalanol A 是一种竞争性、选择性和细胞渗透性的Cyclins/Cdk 复合物抑制剂，优先靶向G2/M 期转变进而抑制癌细胞分化。它通过抑制生理获能依赖性肌动蛋白聚合而抑制精子受精能力。
T19664	ON1231320 GBO-006	Apoptosis; PLK	Apoptosis; Cell Cycle/Checkpoint
	ON1231320 (GBO-006) 是一种高度特异性的 polo 样激酶 2 抑制剂，IC50为 0.31 µM。在有丝分裂 G2/M 期阻断肿瘤细胞周期进程，它可导致细胞凋亡。它是一种芳基磺酰基吡啶并嘧啶酮，具有抗肿瘤活性。
T3459	VK3-OCH3 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na	Others	Others
	VK3-OCH3 (2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na) 是一种通过血红素加氧酶(HO-1) 相关机制的选择性抗肿瘤剂；维生素 K3 类似物。
T10723	CDC25B-IN-1 ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate	Phosphatase	Metabolism
	CDC25B-IN-1 是 CDC25B 的抑制剂，Ki 为 8.5 μM。 CDC25B-IN-1 通过抑制细胞增殖和集落形成来增加 G2/M 期。
T3485	Probimane AT-2153,MM-159	Others	Others
	Probimane (AT-2153) 具有抗增殖作用、细胞周期 G2/M 期阻滞和用 MST-16 阻断人类肿瘤细胞系中的染色体分离。
T64923	Sodium citrate Citrosodine,Natrocitral,柠檬酸钠	Others	Others
	Sodium citrate (Natrocitral) 是柠檬酸的钠盐。Sodium citrate 诱导G2/M 期和S 期细胞凋亡和细胞周期阻滞。Sodium citrate 通过降低抗氧化酶活性引起肝脏氧化损伤。
T78701	Tubulin inhibitor 32	Apoptosis	Apoptosis
	Tubulin inhibitor 32是一种口服活性的新型微管抑制剂，具有抗增殖和抗肿瘤活性，可抑制微管聚合，可诱导细胞凋亡及在G2/M期引起细胞周期停滞。
T63732	EGFR-IN-3	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-3 是一种 EGFR 抑制剂，具有潜在的抗肿瘤活性。EGFR-IN-3 抑制 EGFRwt-TK，诱导细胞凋亡 (apoptosis)，可使细胞在G2/M期阻滞。
T6864	Ixabepilone BMS 247550,Ixempra,Azaepothilone B,伊沙匹隆,BMS 247550-1	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Ixabepilone (Azaepothilone B) 是一种可口服的微管抑制剂，能够与微管蛋白结合，促进微管蛋白的聚合和微管的稳定，使细胞停滞在 G2-M 期，诱导细胞凋亡。
T67746	IMS2186	Others	Others
	IMS2186 是一种抗脉络膜新生血管 (CNV) 试剂，可以使癌细胞周期阻滞在 G2/M 期，由此产生抗增殖和抗血管生成作用。IMS2186 能够减少眼睛渗漏和病变细胞的数量，并且无眼内毒性。
T77729	MY-1076	Apoptosis; YAP	Apoptosis; Stem Cells
	MY-1076 是一种高效的 YAP 抑制剂，具有抗胃癌活性。MY-1076 剂量依赖性诱导G2/M期阻滞，诱导 YAP 降解和细胞凋亡，抑制微管蛋白聚合。MY-1076 抑制 MGC-803、SGC-7901、HCT-116 和 KYSE450 细胞增殖。
T28886	Suprafenacine N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide	Microtubule Associated	Cytoskeletal Signaling
	Suprafenacine (N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide) 是一种细胞渗透性微管去稳定剂，可在 G2/M 期诱导细胞周期停滞和细胞凋亡。它与微管结合并抑制秋水仙碱连接处的聚集。它对癌细胞有选择性，包括耐药癌细胞。
T4451	Estramustine phosphate sodium Ro 21-8837/001,Estramustine phosphate disodium,雌莫司汀磷酸钠	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Estramustine phosphate sodium (Ro 21-8837/001) 是雌二醇类似物，是一种具有口服活性抗微管化疗剂，通过与微管相关蛋白和微管蛋白结合而使微管解聚。它可诱导前列腺癌细胞凋亡，可研究前列腺癌。
T77647	Tubulin polymerization-IN-43	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Tubulin polymerization-IN-43 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂。Tubulin polymerization-IN-43 具有多种作用，通过靶向 Colchicine 位点破坏细胞微管网络，促进白血病细胞的细胞周期停滞在 G2/M 期和细胞凋亡 (apoptosis)。Tubulin polymerization-IN-43 具有抗血管生成活性。
T2090	Lexibulin CYT-997	Apoptosis; Reactive Oxygen Species; Microtubule Associated	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
	Lexibulin (CYT-997) 是一种微管蛋白聚集强效抑制剂，可诱导细胞凋亡，并诱导 GC 细胞中的线粒体ROS 生成。它对多种癌细胞的 IC50 值为 10-100n M，在体内外具有高细胞毒性和血管增生阻断作用。
T3124	Carbendazim Bavistin,Carbendazole,多菌灵,Mercarzole	Antifungal	Microbiology/Virology
	Carbendazim (Mercarzole) 是一种具有抗肿瘤活性的苯并咪唑衍生物，可用于癌症研究。它是一种口服广谱苯并咪唑杀菌剂，可作为真菌疾病研究的杀虫剂。
T41163	ZNL 02-096 Pomalidomide-C3-adavosertib	Apoptosis; Wee1	Apoptosis; Cell Cycle/Checkpoint
	ZNL 02-096 (Pomalidomide-C3-adavosertib) 是一种快速和选择性的 Wee1 降解剂 (IC50=3.58 nM)。ZNL 02-096 可在亚摩尔浓度下选择性降解 Wee1，而不损伤 AZD 1775 的二级靶点 PLK1。在体外 MOLT-4 细胞中，ZNL 02-096 可诱导 Wee1 降解、DNA 损伤积累、细胞周期停滞在 G2/M 期和细胞凋亡。ZNL 02-096 在 300 种癌症细胞系中显示出抗增殖作用。
T13901	SS28	Microtubule Associated	Cytoskeletal Signaling
	SS28 inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase.
T31004	Compound 8H Compound-8H,Compound 8-H,Compound 343	Others	Others
	Compound 8H is an inducer of G2/M-phase cell cycle arrest and cell death in cancer cell lines.
T30768	CB-403 UNII-4V9Q0C88UK,CB403,CB 403	Others	Others
	CB-403 is a cinnamaldehyde derivative that has antitumor effects by blocking cell cycle progression in the G2/M phase.
T13227	Tubulin inhibitor 1	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase.
T83020	Antiproliferative agent-37	Others	Others
	Antiproliferative agent-37 (compound 10J) 通过诱导细胞周期在G2/M期的阻滞来实现其抗增殖效果。
T62458	EGFR-IN-56	Others	Others
	EGFR-IN-56 (Compound 13a) 是一种 EGFR 的有效抑制剂，能够作用于 EGFRT790M (IC50: 541.7 nM) 和 EGFRT790M/L858R (IC50: 132.1 nM)。EGFR-IN-56 能够将癌细胞的细胞周期阻滞在 G2/M 期，并诱导细胞凋亡 (apoptosis)。
T23817	BPTQ B-P-T-Q	Others	Others
	BPTQ is a typical intercalator of DNA that acts by inducing a dose-dependent inhibitory effect on the proliferation of cancer cells by arresting cells at the S and G2/M phase.
T61129	Tubulin polymerization-IN-27	Others	Others
	Tubulin polymerization-IN-27 (compound 5j) is an inhibitor of tubulin polymerization. It has the ability to halt the cell cycle specifically at the G2/M phase and also induce apoptosis [1].
T73413	Cadein1	Others	Others
	Cadein1 是一种异喹啉衍生物，在p53功能缺失的癌细胞中，可导致 G2/M 延迟和caspase 依赖的凋亡。
T79463	Antitumor agent-110	Apoptosis	Apoptosis
	Antitumor agent-110 (compound 13) 是一种抗癌咪唑四嗪，具备良好的渗透性，能够阻滞细胞周期于G2/M期并诱导apoptosis。
T61401	3-(3-Phenoxybenzyl)amino-β-carboline	Others	Others
	3-(3-Phenoxybenzyl)amino-β-carboline is a highly effective tubulin inhibitor, selectively degrading αβ-tubulin heterodimers. It induces cell cycle arrest and apoptosis in the G2/M phase. Additionally, 3-(3-Phenoxybenzyl)amino-β-carboline displays notable anticancer activity [1].
T61616	Antitumor agent-38	Others	Others
	Antitumor agent-38 is a highly effective antitumor compound that exhibits antiproliferative activity towards cancer cells. It induces cell cycle arrest specifically at the late S and G2/M phase, while not impeding microtubule formation or altering cell morphology [1].
T36700	CKD 602	Others	Others
	Topoisomerase I inhibitor. Forms stable DNA-topoisomerase complexes during DNA replication and induces cell cycle arrest in the G2/M phase. Inhibits growth of a range of cancer cell lines in vitro, as well as of ovarian and leukemia tumors in vivo.
T61779	STAT3-IN-9	Others	Others
	STAT3-IN-9, a potent inhibitor of STAT3 activation at Tyr705, exhibits no impact on the phosphorylation of STAT1 at Tyr 701. Additionally, this compound efficiently induces apoptosis and cell cycle arrest specifically at the G2/M phase [1].
T68570	TPI-287	Others	Others
	TPI 287 is a synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule assembly/disassembly dynamics, cell cycle arrest at the G2/M phase, and apoptosis.
T63271	Antitumor agent-62	Others	Others
	Antitumor agent-62 是释放 NO 的抗肿瘤剂，对癌细胞表现出抗增殖作用，能够激活线粒体凋亡 (apoptosis) 通路，能够将细胞周期阻滞到 G2/M 期。
T62796	VEGFR-2-IN-13	Others	Others
	VEGFR-2-IN-13 (Compound 19a) 是一种有效的 VEGFR-2 抑制剂 (IC50: 3.4 nM)。VEGFR-2-IN-13 能够将 HepG2 的细胞周期停滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。
T79429	Tubulin polymerization-IN-50	Others	Others
	Tubulin polymerization-IN-50（compound 7n）是一种Tubulin polymerization抑制剂，其在SK-Mel-28细胞中的IC50值为5.05 μM，能够诱导(cell cycle)阻滞在G2/M期。
T62693	Tubulin polymerization-IN-29	Others	Others
	Tubulin polymerization-IN-29 是一种有效的微管蛋白聚合抑制剂，显示出有效的抗增殖效果。Tubulin polymerization-IN-29 能够诱导 HeLa 细胞的细胞周期阻滞在 G2/M 期。
T63304	Topoisomerase II inhibitor 9	Others	Others
	Topoisomerase II inhibitor 9 是 Topo II 抑制剂 (IC50: 0.97 μM)，也是 DNA 嵌入剂 (IC50: 43.51 μM)，能够在 G2/M 期阻滞 Hep G‐2 细胞周期，诱导细胞凋亡 (apoptosis)。
T60505	Antitumor agent-43	Others	Others
	Antitumor agent-43 (Compound 4B) 是一种有效的抗肿瘤剂，可诱导细胞周期阻滞在G2/M 期。Antitumor agent-43对 T-24 细胞的IC50值为0.5 μM。
T60735	Tubulin polymerization-IN-22	Others	Others
	Tubulin aggregation-IN-22 抑制细胞周期在 G2/M 期，并且诱导细胞凋亡。Tubulin aggregation-IN-22 是一种微管蛋白聚合抑制剂 (IC50 = 8.1 μM)。
T72205	Antiproliferative agent-19	Others	Others
	Antiproliferative agent-19 (化合物 4a) 作为一种抗癌剂，通过诱导细胞凋亡和细胞周期在G2/M期的停滞来对肺癌细胞展现抗增殖活性。
T78686	Apoptosis inducer 11	Apoptosis	Apoptosis
	Apoptosisinducer 11（compound 3u）通过线粒体途径引发细胞凋亡。在非霍奇金淋巴瘤细胞系中，该化合物导致G2/M期停滞和S期显著减少。
T79532	Tubulin polymerization-IN-44	Others	Others
	Tubulin polymerization-IN-44 (7w)为具高效性的微管蛋白聚合抑制剂，其IC50为0.21 μM。该化合物可诱发G2/M期阻塞并触发癌细胞凋亡(apoptosis)，适用于肿瘤研究。
T78862	EGFR-IN-86	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-86（化合物4i）是一种高效的EGFR抑制剂，IC50为1.5 nM，对胶质母细胞瘤表现出强抗癌活性。该化合物能够诱导细胞凋亡并使U87细胞周期在G2/M期发生阻滞。
T78940	EGFR-IN-78	Apoptosis	Apoptosis
	EGFR-IN-78（compound A5）为2-氨基嘧啶衍生物，既是EGFRC797S-TK的可逆抑制剂，也能诱导细胞凋亡(apoptosis)。该化合物展现抗增殖能力，阻止EGFR磷酸化，导致细胞周期在G2/M期暂停。
T69316	DA 3003-2 NSC663285	Others	Others
	DA 3003-2为一种高效的选择性Cdc25抑制剂，展示了抗增殖活性，能诱导细胞周期在G2/M期停滞，并提高P-tyr15Cdc2表达量，显示出对前列腺癌研究的应用潜力。
T60776	Anticancer agent 68	Others	Others
	Anticancer agent 68 is (Compound 12) 是一种抗癌剂。Anticancer agent 68 将细胞阻滞在 G2/M 期并诱导程序性细胞死亡。Anticancer agent 68 通过激活 p53 和 PTEN 诱导上调肿瘤抑制。
T60781	Topoisomerase II inhibitor 8	Others	Others
	Topoisomerase II inhibitor 8 (化合物 22) 显示出良好的抗增殖活性，并将细胞周期阻滞在 G2/M 期。Topoisomerase II inhibitor 8是拓扑异构酶 II 的有效抑制剂 (IC 50 = 0.52 μM)。
T60766	Topoisomerase I inhibitor 3	Others	Others
	Topoisomerase I inhibitor 3 (Compound ZML-14) 诱导 HepG2 细胞凋亡，并在 G2/M 期阻滞细胞周期。Topoisomerase I inhibitor 3 是与拓扑异构酶 I-DNA 复合物相互作用的拓扑异构酶 I 抑制剂。
T60452	PCAF-IN-2	Others	Others
	PCAF-IN-2 (compound 17) 是一种有效的 PCAF 抑制剂(IC50 = 5.31 µM)。PCAF-IN-2 具有抗肿瘤活性。PCAF-IN-2 诱导细胞凋亡并且阻滞细胞周期在 G2/M 期。

化合物

Cat.No: T1753

Target: Microtubule Associated

Aminopurvalanol A

Cat.No: T22260

Target: CDK

Cat.No: T19664

Synonym: GBO-006

Target: Apoptosis, PLK

Cat.No: T3459

Synonym: 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-na

Target: Others

Cat.No: T10723

Synonym: ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate

Target: Phosphatase

Cat.No: T3485

Synonym: AT-2153,MM-159

Target: Others

Cat.No: T64923

Synonym: Citrosodine,Natrocitral,柠檬酸钠

Target: Others

Tubulin inhibitor 32

Cat.No: T78701

Target: Apoptosis

Cat.No: T63732

Target: Apoptosis, EGFR

Cat.No: T6864

Synonym: BMS 247550,Ixempra,Azaepothilone B,伊沙匹隆,BMS 247550-1

Target: Apoptosis, Microtubule Associated

Cat.No: T67746

Target: Others

Cat.No: T77729

Target: Apoptosis, YAP

Cat.No: T28886

Synonym: N'-[(E)-(4-methylphenyl)methylidene]-4,5,6,7-tetrahydro-1H-indazole-3-carbohydrazide

Target: Microtubule Associated

Estramustine phosphate sodium

Cat.No: T4451

Synonym: Ro 21-8837/001,Estramustine phosphate disodium,雌莫司汀磷酸钠

Target: Apoptosis, Microtubule Associated

Tubulin polymerization-IN-43

Cat.No: T77647

Target: Apoptosis, Microtubule Associated

Cat.No: T2090

Synonym: CYT-997

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated

Cat.No: T3124

Synonym: Bavistin,Carbendazole,多菌灵,Mercarzole

Target: Antifungal

Cat.No: T41163

Synonym: Pomalidomide-C3-adavosertib

Target: Apoptosis, Wee1

Cat.No: T13901

Target: Microtubule Associated

Cat.No: T31004

Synonym: Compound-8H,Compound 8-H,Compound 343

Target: Others

Cat.No: T30768

Synonym: UNII-4V9Q0C88UK,CB403,CB 403

Target: Others

Tubulin inhibitor 1

Cat.No: T13227

Target: Microtubule Associated

Antiproliferative agent-37

Cat.No: T83020

Target: Others

Cat.No: T62458

Target: Others

Cat.No: T23817

Synonym: B-P-T-Q

Target: Others

Tubulin polymerization-IN-27

Cat.No: T61129

Target: Others

Cat.No: T73413

Target: Others

Antitumor agent-110

Cat.No: T79463

Target: Apoptosis

3-(3-Phenoxybenzyl)amino-β-carboline

Cat.No: T61401

Target: Others

Antitumor agent-38

Cat.No: T61616

Target: Others

Cat.No: T36700

Target: Others

Cat.No: T61779

Target: Others

Cat.No: T68570

Target: Others

Antitumor agent-62

Cat.No: T63271

Target: Others

Cat.No: T62796

Target: Others

Tubulin polymerization-IN-50

Cat.No: T79429

Target: Others

Tubulin polymerization-IN-29

Cat.No: T62693

Target: Others

Topoisomerase II inhibitor 9

Cat.No: T63304

Target: Others

Antitumor agent-43

Cat.No: T60505

Target: Others

Tubulin polymerization-IN-22

Cat.No: T60735

Target: Others

Antiproliferative agent-19

Cat.No: T72205

Target: Others

Apoptosis inducer 11

Cat.No: T78686

Target: Apoptosis

Tubulin polymerization-IN-44

Cat.No: T79532

Target: Others

Cat.No: T78862

Target: EGFR

Cat.No: T78940

Target: Apoptosis

Cat.No: T69316

Synonym: NSC663285

Target: Others

Anticancer agent 68

Cat.No: T60776

Target: Others

Topoisomerase II inhibitor 8

Cat.No: T60781

Target: Others

Topoisomerase I inhibitor 3

Cat.No: T60766

Target: Others

Cat.No: T60452

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TQ0089	Juglanin	Apoptosis; JNK; Autophagy	Apoptosis; Autophagy; MAPK
	Juglanin 是来自金鸡脚的一种黄酮类天然产物，是一种 JNK 的激活剂，能诱导人乳腺癌细胞的凋亡和自噬，具有炎症和抗肿瘤活性。
T5669	Citric acid monohydrate	Others	Others
	Citric acid monohydrate 是一种存在于柑橘类水果中的三羧酸。柠檬酸因其抗氧化特性而被用作药物制剂中的赋形剂。它保持活性成分的稳定性并用作防腐剂。
T5S0636	Citric acid 柠檬酸,Citro,Citretten	Apoptosis; Others; Endogenous Metabolite; Antibacterial; Antibiotic	Apoptosis; Metabolism; Microbiology/Virology; Others
	Citric acid (Citro) 是柑橘类水果中发现的弱有机三羧酸。柠檬酸是食品添加剂和天然防腐剂。
TN2058	Persicogenin	Anti-infection	Microbiology/Virology
	Persicogenin 是分离自 Rhus retinorrhoea 中，具有抗癌作用。
T4S1335	Daphnoretin Dephnoretin,西瑞香素,Thymelol	Influenza Virus; Caspase; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome
	Daphnoretin (Thymelol) 是从了哥王中提取得到的一种天然产物，具有抗癌和抗病毒活性。它通过在 G2/M 期连续阻断细胞并激活 caspase-3 通路导致 HOS 细胞死亡。
T81818	Metachromins X
	Metachromins X，一倍半萜醌类化合物，能阻碍HeLa/Fucci2细胞在S/G2/M期的细胞周期。
TN5190	Tryprostatin A	Topoisomerase; Antifection	DNA Damage/DNA Repair; Microbiology/Virology
	Tryprostatin A is an inhibitor of breast cancer resistance protein. Tryprostatin A and tryprostatin B are indole alkaloid-based fungal products that inhibit mammalian cell cycle at the G2/M phase.
TN5336	9-Oxo-10,11-dehydroageraphorone 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone,泽兰二酮
	9-Oxo-10,11-dehydroageraphorone has acaricidal activity. It induces hepatotoxicity and cholestasis in rats. 9-Oxo-10,11-dehydroageraphorone also effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M pha
TN2344	Swainsonine Tridolgosir	Apoptosis; Others; Antibiotic	Apoptosis; Microbiology/Virology; Others
	Swainsonine (Tridolgosir) 是一种从黄芪中分离出来的一种生物碱，是一种强效和可逆的α-甘露糖苷酶抑制剂。Swainsonine 具有抗肿瘤活性，可诱导细胞凋亡和细胞周期停滞在 G2/M 期。
T75602	Albanol B	Others	Others
	Albanol B 是一种芳基苯并呋喃衍生物，可从桑葚中分离得到。Albanol B 具有抗阿尔茨海默病、抗菌和抗氧化活性。Albanol B 抑制癌细胞增殖，下调 CDK1表达。Albanol B 还会诱导细胞周期停滞在 G2/M 期，诱导细胞凋亡 (apoptosis)。Albanol B 诱导线粒体 ROS 产生并增加 AKT 和 ERK1/2的磷酸化水平。
T36961	Malformin C	Others	Others
	Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human T-cell leukemia-derived Jurkat cells (IC50 = 0.9 nM). It less potently abrogates colchicine-induced M phase arrest in Jurkat cells (IC50 = 24 nM). Malformin C inhibits cell growth dose-dependently in Colon 38 and HCT 115 cancer cells (IC50s = 0.27 and 0.18 μM, respectively) but ...
TN5639	Rocaglaol Ferrugin,Aglaiastatin A
	Rocaglaol is a potent anticancer drug that induces apoptosis of LNCaP cells through the mitochondrial pathway and its G2/M-phase cell cycle arrest is associated with the down-regulation of Cdc25C and the dephosphorylation of Cdc2. Rocaglaol can reduce tis

天然产物

Cat.No: TQ0089

Target: Apoptosis, JNK, Autophagy

Citric acid monohydrate

Cat.No: T5669

Target: Others

Cat.No: T5S0636

Synonym: 柠檬酸,Citro,Citretten

Target: Apoptosis, Others, Endogenous Metabolite, Antibacterial, Antibiotic

Cat.No: TN2058

Target: Anti-infection

Cat.No: T4S1335

Synonym: Dephnoretin,西瑞香素,Thymelol

Target: Influenza Virus, Caspase, PKC

Cat.No: T81818

Cat.No: TN5190

Target: Topoisomerase, Antifection

9-Oxo-10,11-dehydroageraphorone

Cat.No: TN5336

Synonym: 4,7(11)-Cadinadiene-3,8-dione,DTD,7,11-Dehydro-8-oxoageraphorone,泽兰二酮

Cat.No: TN2344

Synonym: Tridolgosir

Target: Apoptosis, Others, Antibiotic

Cat.No: T75602

Target: Others

Cat.No: T36961

Target: Others

Cat.No: TN5639

Synonym: Ferrugin,Aglaiastatin A

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00604	CDTA Protein, E. coli, Recombinant (His) Cytolethal distending toxin subunit A,CDTA,CDT A	E. coli	E. coli
	CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for the delivery of CdtB.
TMPH-03269	COMMD5 Protein, Rat, Recombinant (His & Myc) COMM domain-containing protein 5,COMMD5,Hypertension-related...	Rat	E. coli
	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B.
TMPJ-00988	SEPHS1 Protein, Human, Recombinant (His) water dikinase 1,SELD,Selenophosphate synthase 1,SEPHS1,SPS1...	Human	HEK293 Cells
	Selenophosphate synthetase 1 (SEPHS1) belongs to the selenophosphate synthase 1 family, Class II subfamily. It has four different isoforms by alternative splicing. Isoform 1 and isoform 2 are gradually expressed during the cell cycle until G2/M phase and then decreased, which Isoform 3 is gradually expressed during the cell cycle until S phase and then decreased. SEPHS1 can be activated by phosphate ions and by potassium ions. It can synthesize synthesizes selenophosphate from selenide and ATP....
TMPY-03672	Survivin Protein, Human, Recombinant BIRC5,IAP4,API4,baculoviral IAP repeat containing 5,EPR-1	Human	E. coli
	BIRC5, also known as Survivin and EPR-1, is a member of theIAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-dependently and highly expressed at mitosis. As a multitasking protein, BIRC5 has dual roles in promoting cell proliferation and preventing apoptosis. Survivin is a component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation...
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p33(CDK2)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...
TMPH-00536	Epstein-Barr virus (strain AG876) EBNA2 Protein (His & Myc) Epstein-Barr nuclear antigen 2,EBNA2	EBV	P. pastoris (Yeast)
	Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-ass...
TMPY-02496	Rad6/UBE2A Protein, Human, Recombinant (His) UBC2,HHR6A,MRXS30,MRXSN,RAD6A,ubiquitin-conjugating enzyme E...	Human	E. coli
	Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A), encoded by human DNA repair genes HHR6A, belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication repair and induced mutagenesis. UBE2A is described as a CDK2 substrate. It is the human homologue of the product of the Saccharomyces cerevisiae RAD6 / UBC2 gene, a member of the family of ubiquitin-conjugating enzymes. In vivo, HHR6A phosphorylation peaks during the G2/M phase o...
TMPH-02613	ATF-5 Protein, Mouse, Recombinant (His & Myc) Transcription factor ATFx,Transcription factor-like protein ...	Mouse	E. coli
	Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcrip...

重组蛋白

CDTA Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00604

Species: E. coli

Expression System: E. coli

COMMD5 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03269

Species: Rat

Expression System: E. coli

SEPHS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00988

Species: Human

Expression System: HEK293 Cells

Survivin Protein, Human, Recombinant

Cat.No: TMPY-03672

Species: Human

Expression System: E. coli

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

Epstein-Barr virus (strain AG876) EBNA2 Protein (His & Myc)

Cat.No: TMPH-00536

Species: EBV

Expression System: P. pastoris (Yeast)

Rad6/UBE2A Protein, Human, Recombinant (His)

Cat.No: TMPY-02496

Species: Human

Expression System: E. coli

ATF-5 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02613

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T70808	Cabazitaxel-d6
	Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance...
T71055	Albendazole-d7
	Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben...

同位素标记化合物

Cat.No: T70808

Cat.No: T71055

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