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Search Results for " g1 phase "

Targets Recommended: Others

106

抑制剂 & 化合物

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天然产物

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化合物库

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重组蛋白

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同位素标记化合物

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Cat. No.	Product Name
L8100	细胞周期化合物库		677 compounds
	677 种细胞周期相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；

化合物库

细胞周期化合物库

Cat.No: L8100

Compounds: 677

Cat. No.	Product Name	Target	Signaling Pathways
T7969	Dipyrithione	Others	Others
	Dipyrithione 似乎具有新的细胞毒性和强大的广谱抗肿瘤活性。
T7057	Methylstat	Histone Demethylase; Others	Chromatin/Epigenetic; Others
	Methylstat 是一种含有 Jumonji C 结构域的组蛋白去甲基化酶 (JMJD) 抑制剂的甲酯前药，具有良好的细胞渗透性。在体外试验中，methylstat 的游离酸可抑制 JMJD2A、JMJD2C、JMJD2E、PHF8 和 JMJD3，IC50 值分别约为 4.3、3.4、5.9、10 和 43 µM。 Methylstat 抑制 JMJD2C 敏感的食管癌细胞系 KYSE150 的生长，GI50 为 5.1 µM，而 methylstat 的游离酸在高达 100 µM 时不抑制细胞生长。 Methylstat 以浓度依赖性方式在多个位点诱导组蛋白高甲基化（KYSE150 细胞中 H3K4me3 和 H3K9me3 的 EC50 = 10.3 和 8.6 µM，MCF-7 细胞中的 EC50 分别为 6.7 和 6.3 µM）。
T8616	Fasentin N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide	transporter	Metabolism
	Fasentin (N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide) 是葡萄糖摄取抑制剂，可抑制GLUT-1/GLUT-4转运蛋白，优先抑制 GLUT4，IC50为 68 μM。它是死亡受体刺激敏化剂，可敏化细胞对 FAS 诱导的细胞死亡，具有抗血管生成活性。
T4321	Indisulam E 7070	CDK; Carbonic Anhydrase	Cell Cycle/Checkpoint; Metabolism
	Indisulam (E 7070) 是碳酸酐酶抑制剂。它是细胞周期 G1期的靶向化合物，能够抑制 CDK2及周期蛋白 E 的激活，阻止 G1/S 的转化。它可以募集 DCAF15诱导RBM39降解来靶向剪接，具有抗癌作用。
T61884	C6 Ceramide N-hexanoylsphingosine,N-(hexanoyl)sphing-4-enine	Apoptosis	Apoptosis
	C6 Ceramide (N-hexanoylsphingosine) 是神经酰胺途径的一种激活剂，通过激活ERK使细胞停滞在G0/G1期，可以在多种癌细胞系中发挥作用。
T73577	TJ08	Apoptosis	Apoptosis
	TJ08 是一种具有抗癌的1,2,5-三取代苯并咪唑衍生物，能够有效诱导G1/S期阻滞，同时促进多种癌细胞的凋亡作用。
T83641	HNPMI	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	HNPMI 是一种 EGFR 抑制剂，诱导 CRC 细胞的G0/G1 期停滞结直肠癌，可调节与细胞凋亡相关的酶，可促进细胞凋亡，可用于研究结直肠癌。
T61722	ZDLD20	Apoptosis	Apoptosis
	ZDLD20 是一种具有口服活性和选择性的CDK4抑制剂，是一种 β-咔啉类化合物，具有抗 HCT116 和抗癌活性，抑制集落形成、抑制侵袭和迁移、诱导细胞凋亡和阻止细胞周期的 G1 期。
T22317	DRB18	transporter	Metabolism
	DRB18 is a highly effective pan-class inhibitor of glucose transporter proteins (GLUT). It significantly modulates energy-related metabolism in A549 cells by inducing alterations in the abundance of metabolites associated with glucose-related pathways. DRB18 exerts its effects by promoting G1/S phase arrest, increasing oxidative stress, and prompting necrotic cell death, ultimately displaying notable anti-tumor activity [1].
T83626	YS-67	Apoptosis; EGFR; Akt	Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	YS-67 是一种可口服且具有选择性和高效性的 EGFR 抑制剂，具有抗肿瘤活性，抑制 p-EGFR 和 p-AKT，抑制 A549、PC-9 和 A431 细胞的增殖。YS-67在 G0/G1 期阻止细胞周期进程并诱导细胞凋亡，可用于研究非小细胞肺癌。
T36082	Cysmethynil	Autophagy; Ras	Autophagy; GPCR/G Protein; MAPK
	Cysmethynil 是一种基于吲哚的 Icmt 时间依赖性抑制剂，具有抗肿瘤活性，对 RAS 膜结合和 EGF的信号转导有抑制作用。Cysmethynil 诱导细胞周期阻滞在 G1 期，诱导细胞自噬，可用于研究实体肿瘤。
T21872	CCT018159	Apoptosis; HSP	Apoptosis; Cytoskeletal Signaling; Metabolism
	CCT018159 是一种 3,4-二芳基吡唑间苯二酚，是一种 ATP 竞争性HSP90ATPase 抑制剂，对人 Hsp90β 和酵母 Hsp90 具有抑制作用，IC50分别为 3.2 和 6.6 μM。CCT018159 抑制与侵袭和血管生成有关的关键内皮细胞和肿瘤细胞功能。CCT018159 引起与 G1 期阻滞相关的细胞抑制并诱导细胞凋亡。
T16522	Phenoxodiol 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E	Apoptosis; IAP; Caspase; Topoisomerase; p53	Apoptosis; DNA Damage/DNA Repair; Proteases/Proteasome
	Phenoxodiol (Idronoxil) 是合成genestein 的类似物，激活线粒体caspase 系统，抑制XIAP，使癌细胞对fas 介导的凋亡敏感。它在细胞周期的G1/S 期诱导细胞周期阻滞，通过独立于p53的方式上调p21WAF1。它通过稳定可分裂复合物抑制DNA 拓扑异构酶II，从而阻止DNA 复制。
T35900	JAK2-IN-7 JAK2-IN-7	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	JAK2-IN-7 是一种选择性 JAK2抑制剂，对 JAK2，SET-2 和 Ba/F3V617F 细胞的IC50为 3、11.7 和 41 nM。 JAK2-IN-7 的选择性是 JAK1, JAK3，FLT3 的 14 倍以上。JAK2-IN-7 刺激细胞周期停滞在 G0/G1 期，并诱导肿瘤细胞凋亡 (apoptosis)，具有抗肿瘤活性。
T77697	BML-278 BML278,BML 278	Sirtuin; Histone Methyltransferase	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BML-278 是一种 SIRT1 激活剂，EC150 值为 1 μM。BML-278 增加父本和母本原核中的 H3K9 甲基化并抑制 H3K9 乙酰化，可用于改善早期胚胎发育。BML-278 促使原代人间充质细胞的细胞周期停止在 G1/S 期，可用于延缓衰老。BML-278 减少 U937 细胞中的微管蛋白乙酰化，增加小鼠 C2C12 成肌细胞的线粒体密度。
T33380	MI-389	PROTACs	PROTAC
	MI-389 is a protein degrader, targeting the translation termination factor G1 to S phase transition 1 (GSPT1).
T26194	SKLB70326 SKLB 70326,SKLB-70326	Others	Others
	SKLB70326 is a cell-cycle progression inhibitor that acts by inducing G0/G1 phase arrest and apoptosis in human hepatic carcinoma cells.
T29026	Tylophorine NSC 76387,Tylophorin	Others	Others
	Tylophorine is a major alkaloid of Tylophora indica with anti-inflammatory and antitumor activity. Tylophorine arrests carcinoma cells at G1 phase by downregulating cyclin A2 expression.
T79474	GSPT1 degrader-1	Apoptosis	Apoptosis
	GSPT1 degrader-1 (compound 9q) 是通过泛素蛋白酶体系统有效实现 G1 至 S 相变 1 (GSPT1) 降解的化合物。此外，该化合物能诱导G0/G1 期细胞停滞及细胞凋亡 (apoptosis)。
T6844	GGTI298 Trifluoroacetate GGTI 298,GGTI 298 TFA salt	Apoptosis; Transferase; Ras	Apoptosis; GPCR/G Protein; MAPK; Metabolism
	GGTI298 Trifluoroacetate (GGTI 298 TFA salt) 是一种GGTase I 抑制剂，能够抑制Rap1A 且IC50值为3μM，对Ha-Ras 的作用很小IC50值 > 20 μM。
T61719	DC-CPin711	Others	Others
	DC-CPin711, a potent and selective inhibitor of the bromodomain of CREB-binding protein (CBP) with an IC50 of 0.0626 μM, effectively halts the cell cycle at the G1 phase and promotes apoptosis [1].
T63594	Topoisomerase IIα-IN-3	Others	Others
	Topoisomerase IIα-IN-3 是 DNA 插入型 topoisomerase-Iiα 抑制剂，能够将细胞周期阻滞在 G0/G1 期，并诱导细胞凋亡 (apoptosis)。
T72722	Physachenolide C	Epigenetic Reader Domain	Chromatin/Epigenetic
	Physachenolide C 是一种选择性BET抑制剂，具有诱导细胞凋亡(apoptosis)和引起细胞周期在G0-G1期停滞的抗肿瘤活性。
T61631	VEGFR-2-IN-23	Others	Others
	VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an impressive IC 50 value of 0.34 nM. This compound exhibits notable antitumor activity, capable of inducing apoptosis and cell cycle arrest specifically at the G1 phase [1].
T72411	Kobusine derivative-2	Others	Others
	Kobusine derivative-2，一种kobusine衍生物，对癌细胞显示出抗增殖活性，并能诱导MDA-MB-231细胞在亚G1期阻滞，表现出抗癌活性。
T63002	VEGFR-2-IN-15	Others	Others
	VEGFR-2-IN-15 (Compound 14b) 是一种 VEGFR-2 的有效抑制剂。VEGFR-2-IN-15 能够抑制 HepG2 细胞在 Pre-G1 期的生长，诱导细胞凋亡。
T63360	DNA topoisomerase II inhibitor 1	Others	Others
	DNA topoisomerase II inhibitor 1 是 DNA 拓扑异构酶 II 的有效抑制剂，能够将细胞周期停滞在亚 G1 期，并诱导细胞凋亡 (apoptosis) ，具有抗增值作用。
T61412	Anticancer agent 47	Others	Others
	Anticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities and inducing apoptosis as well as cell cycle arrest at G0/G1 phase. Moreover, Anticancer agent 47 has exhibited significant in vivo antitumor activities [1].
T61299	PAK4-IN-2	Others	Others
	PAK4-IN-2 is an exceptionally effective inhibitor of PAK4, exhibiting an IC 50 value of 2.7 nM. This compound is capable of arresting MV4-11 cells at the G0/G1 phase and inducing cell apoptosis. It holds significant potential in cancer research [1].
T74440	YM281	Others	Others
	YM281是高效EZH2抑制剂，具备诱导细胞凋亡(apoptosis)及使细胞周期在G0/G1期停滞的能力。在体内，YM281展现出对抗肿瘤的活性，并有研究淋巴瘤的潜力。
T62439	VEGFR-2-IN-14	Others	Others
	VEGFR-2-IN-14 (Compound 5) 是一种 VEGFR-2 的有效抑制剂。VEGFR-2-IN-14 对 HepG2 细胞在 Pre-G1 期的生长具有抑制作用，并能够诱导细胞凋亡 (apoptosis)。
T64026	ERα antagonist 1	Others	Others
	ERα antagonist 1 是选择性的、有效的、共价雌激素受体 α (ERα)拮抗剂。ERα antagonist 1 能够将 MCF-7 细胞的细胞周期阻滞在 G0/G1 期，并诱导其凋亡 (apoptosis)。
T74525	PROTAC EGFR degrader 6	Others	Others
	PROTACEGFRdegrader 6 是一种PROTACEGFR 降解剂，可有效降解 HCC827 细胞中的EGFRDel19，DC50为 45.2 nM。PROTACEGFRdegrader 6 显著诱导 HCC827 细胞凋亡 (apoptosis) 并将细胞阻滞在 G1 期。
T82762	Cdc25A (80-93) (human)
	Cdc25A (80-93) (human)为调控细胞周期蛋白D1及G1/S转换中相关蛋白表达，进而控制细胞增殖与肿瘤发生的多肽。该化合物在癌症研究中具应用价值。
T83023	Antiproliferative agent-26	Others	Others
	Antiproliferative agent-26 (compound 4g) 是抗增殖药物，(10 μM) 对多种癌细胞如白血病、中枢神经系统肿瘤、黑色素瘤、肾癌和乳腺癌具有抑制效果。该药物能够阻止集落形成，并在(5 μM) 和 (25 μM) 浓度作用下导致细胞周期在G1期/S期停滞。
TP1105	α-Factor Mating Pheromone, yeast (TFA) α-Factor Mating Pheromone, yeast (TFA)(59401-28-4,FREE),Mating Factor α (TFA)
	The alpha factor pheromone arrests yeast in the G1 phase of their cell cycle. Alpha Factor Mating Pheromone induces the expression of mating genes, changes in nuclear architecture, and polarzes growth toward the mating partner.
T78549	Ethylene glycol dimethacrylate	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Ethylene glycol dimethacrylate 是一种具有细胞毒性和基因毒性作用的甲基丙烯酸酯单体。它可增加人牙龈成纤维细胞 (HGF) 内的活性氧 (ROS) 产生，引发 DNA 损伤和细胞凋亡 (apoptosis)，并使细胞周期在 G1/G0 期停滞。
T63123	FAK inhibitor 6	Others	Others
	化合物26f 不仅优化了有效抑制酶（IC50= 28.2 nM），也表现出相对较少的细胞毒性（IC50= 3.32 μM），并以剂量依赖性方式诱导 MDA-MB-231细胞凋亡，有效阻断 G0/G1期MDA-MB-231细胞。
T74768	Antitumor agent-92	Apoptosis	Apoptosis
	Antitumor agent-92为一种淫羊藿素衍生物，能够引起细胞周期在G0/G1期的停滞，并诱导细胞凋亡。该化合物展现出在肝细胞癌(HCC)研究中的应用潜力。
T73512	ZC0109	Others	Others
	ZC0109 是 IDO1和硫氧还蛋白还原酶 1 (TrxR1) 的双抑制剂，IC50分别为 50 nM 和 3.0 μM。ZC0109 诱导活性氧 (ROS) 积累，使细胞周期阻滞于 G1/S 期，导致癌细胞凋亡 (apoptosis)。
T63599	Anticancer agent 54	Others	Others
	Anticancer agent 54 是有效的抗癌剂，其抗癌活性取决于 DNA 嵌入和 ROS 生成。 Anticancer agent 54 能够将细胞周期阻滞在 G0/G1 期，并诱导细胞凋亡 (apoptosis)，具有抗增殖效果。
T63470	PI3K/mTOR Inhibitor-8	Others	Others
	PI3K/mTOR Inhibitor-8 是 PI3K (PI3Kα IC50: 0.46 nM) 和 mTOR (mTOR IC50: 12 nM) 双重抑制剂。PI3K/mTOR Inhibitor-8 能够将 HCT-116 细胞的细胞周期阻滞在G1/S 期，并诱导其凋亡 (apoptosis)。
T61501	Topoisomerase I inhibitor 5	Others	Others
	Topoisomerase I inhibitor 5 is an efficient inhibitor of topoisomerase I, with an IC50 value. It effectively disrupts DNA and inhibits the activity of topoisomerase I. Moreover, it can induce apoptosis in MCF-7 cells and arrest the cell cycle at the G1 phase. Topoisomerase I inhibitor 5 also exhibits potency in reversing P-gp-mediated resistance to Adriamycin [1].
T36944	Ara-G	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物，可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP)，从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。
T79466	Antitumor agent-111	c-Met/HGFR	Tyrosine Kinase/Adaptors
	Antitumor agent-111（compound 46）是一款c-Met激酶抑制剂，IC50为46 nM，显示出抗肿瘤和抗增殖特性。该化合物能够导致细胞周期在G0/G1期停滞，并诱发细胞凋亡（apoptosis）。
T62916	GEM144	Others	Others
	GEM144 是一种有效的、口服具有活力的 DNA polymerase α(POLA1) 和HDAC 11 双重抑制剂。GEM144 能够诱导 p53 乙酰化、激活 p21，将细胞周期阻滞在 G1/S 期，并诱导细胞凋亡。
T61596	EGFR/HER2/DHFR-IN-1	Others	Others
	EGFR/HER2/DHFR-IN-1 is a highly selective and potent anticancer compound specifically targeting MCF-7 breast cancer cells. It acts as a multi-inhibitor, targeting the EGFR/HER2 kinase and DHFR enzymes, with IC50 values of 0.153 μM, 0.108 μM, and 0.291 μM, respectively. Its mechanism of action involves cell cycle arrest at the G1/S phase and induction of apoptosis in cells [1].
T62917	MIR002	Others	Others
	MIR002 是一种有效的、口服具有活力的 DNA polymerase α (POLA1) 和 HDAC 11 双重抑制剂，具有显著的体内抗肿瘤活性。MIR002 能够诱导 p53 乙酰化、激活 p21，将细胞周期阻滞在 G1/S 期，并诱导细胞凋亡。
T64222	Antitumor agent-55	Others	Others
	Antitumor agent-55 (compound 5q) 是一种有效的抗肿瘤剂，能够有效的抑制PC3 (IC50: 0.91 μM)。Antitumor agent-55 能够将 PC3 的细胞周期阻滞 G1/S 期，诱导其凋亡，抑制细胞迁移，阻碍 PC3 的形成。
T63693	EGFR-IN-55	Others	Others
	EGFR-IN-55 是 EGFR 的有效抑制剂，能够作用于 EGFRWT (IC50: 70 nM) 和 EGFRL858R/T790M (IC50: 3.9 nM) 。EGFR-IN-55 能够将 NCI-H1975 细胞的细胞周期阻滞在 G0/G1 期，表现出抗癌效果。

化合物

Cat.No: T7969

Target: Others

Cat.No: T7057

Target: Histone Demethylase, Others

Cat.No: T8616

Synonym: N-[4-chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

Target: transporter

Cat.No: T4321

Synonym: E 7070

Target: CDK, Carbonic Anhydrase

Cat.No: T61884

Synonym: N-hexanoylsphingosine,N-(hexanoyl)sphing-4-enine

Target: Apoptosis

Cat.No: T73577

Target: Apoptosis

Cat.No: T83641

Target: Apoptosis, EGFR

Cat.No: T61722

Target: Apoptosis

Cat.No: T22317

Target: transporter

Cat.No: T83626

Target: Apoptosis, EGFR, Akt

Cat.No: T36082

Target: Autophagy, Ras

Cat.No: T21872

Target: Apoptosis, HSP

Cat.No: T16522

Synonym: 脱氢雌马酚,Dehydroequol,Idronoxil,Haginin E

Target: Apoptosis, IAP, Caspase, Topoisomerase, p53

Cat.No: T35900

Synonym: JAK2-IN-7

Target: JAK

Cat.No: T77697

Synonym: BML278,BML 278

Target: Sirtuin, Histone Methyltransferase

Cat.No: T33380

Target: PROTACs

Cat.No: T26194

Synonym: SKLB 70326,SKLB-70326

Target: Others

Cat.No: T29026

Synonym: NSC 76387,Tylophorin

Target: Others

GSPT1 degrader-1

Cat.No: T79474

Target: Apoptosis

GGTI298 Trifluoroacetate

Cat.No: T6844

Synonym: GGTI 298,GGTI 298 TFA salt

Target: Apoptosis, Transferase, Ras

Cat.No: T61719

Target: Others

Topoisomerase IIα-IN-3

Cat.No: T63594

Target: Others

Physachenolide C

Cat.No: T72722

Target: Epigenetic Reader Domain

Cat.No: T61631

Target: Others

Kobusine derivative-2

Cat.No: T72411

Target: Others

Cat.No: T63002

Target: Others

DNA topoisomerase II inhibitor 1

Cat.No: T63360

Target: Others

Anticancer agent 47

Cat.No: T61412

Target: Others

Cat.No: T61299

Target: Others

Cat.No: T74440

Target: Others

Cat.No: T62439

Target: Others

ERα antagonist 1

Cat.No: T64026

Target: Others

PROTAC EGFR degrader 6

Cat.No: T74525

Target: Others

Cdc25A (80-93) (human)

Cat.No: T82762

Antiproliferative agent-26

Cat.No: T83023

Target: Others

α-Factor Mating Pheromone, yeast (TFA)

Cat.No: TP1105

Synonym: α-Factor Mating Pheromone, yeast (TFA)(59401-28-4,FREE),Mating Factor α (TFA)

Ethylene glycol dimethacrylate

Cat.No: T78549

Target: Reactive Oxygen Species

FAK inhibitor 6

Cat.No: T63123

Target: Others

Antitumor agent-92

Cat.No: T74768

Target: Apoptosis

Cat.No: T73512

Target: Others

Anticancer agent 54

Cat.No: T63599

Target: Others

PI3K/mTOR Inhibitor-8

Cat.No: T63470

Target: Others

Topoisomerase I inhibitor 5

Cat.No: T61501

Target: Others

Cat.No: T36944

Target: Nucleoside Antimetabolite/Analog

Antitumor agent-111

Cat.No: T79466

Target: c-Met/HGFR

Cat.No: T62916

Target: Others

EGFR/HER2/DHFR-IN-1

Cat.No: T61596

Target: Others

Cat.No: T62917

Target: Others

Antitumor agent-55

Cat.No: T64222

Target: Others

Cat.No: T63693

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3S1416	Decursin Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素	Apoptosis; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling
	Decursin (Decursinol angelate) 是一种细胞毒性剂，是一种来自朝鲜当归根的有效蛋白激酶 C 激活剂。它通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。它通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长，迁移和侵袭。
T1882	Meisoindigo N-Methylisoindigotin,Methylisoindigotin,Natura-α,甲异靛,Dian III,异甲靛	Apoptosis	Apoptosis
	Meisoindigo (Natura-α) 是 Indirubin 的衍生物，可以造成急性髓细胞性白血病细胞周期在 G0/G1 期停滞，并诱导凋亡，具有高抗肿瘤活性。
T3805	Prim-O-glucosylcimifugin 升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside	TNF; COX; JAK; NO Synthase	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Stem Cells
	Prim-O-glucosylcimifugin (Cimifugin 7-glucoside) 具有强效的抗炎作用。通过调节 JAK2/STAT3 信号传导可抑制iNOS 和COX-2表达。
T2996	Tetrandrine NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素	Potassium Channel; Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Tetrandrine (Sinomenine A) 是来自粉防己的一种双苯基异喹啉生物碱，可抑制电压门控钙离子通道 (ICa) 和 Ca2+激活的钾离子通道。
TN1805	Isosilybin B	Apoptosis; Androgen Receptor	Apoptosis; Endocrinology/Hormones
	Isosilybin B 是一种从水飞蓟中提取的黄酮木脂素，具有抗前列腺癌 (PCA) 活性，对癌细胞增殖有抑制作用，促使 G1 期阻滞和凋亡。Isosilybin B 诱导雄激素受体降解。
T36473	trans-Nerolidol	Antifungal	Microbiology/Virology
	trans-Nerolidol 是从撒哈拉瓦莲属植物的地上部分分离出来的倍半萜醇，具有抗真菌活性。trans-Nerolidol 以剂量依赖性方式抑制细胞增殖，诱导细胞周期停滞在 G1 期
T3314	Perillyl alcohol Isocarveol,Perilla alcohol,紫苏醇	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	Perillyl alcohol (Isocarveol) 是一种单萜，可在不影响正常细胞的情况下诱导肿瘤细胞凋亡。
T2S2043	Dracorhodin perchlorate Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate	Apoptosis; Others	Apoptosis; Others
	Dracorhodin perchlorate 是来源于中药血竭的一种天然产物。它抑制细胞生长，并以剂量和时间依赖性方式诱导成纤维细胞凋亡，将细胞周期阻滞在 G1 期，可作为抗乳腺癌的候选药物。
T3386	Kaempferitrin Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷	cell cycle arrest; Glucokinase; IGF-1R	Cell Cycle/Checkpoint; Metabolism; Tyrosine Kinase/Adaptors
	Kaempferitrin (Lespenephryl) 是天然黄酮苷类化合物，具有缓解疼痛、抗糖尿病、消炎、抗肿瘤和化疗作用，可激活胰岛素信号传导。
T37067	9-hydroxy Stearic Acid	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	9-hydroxy Stearic Acid 是一种羟基脂肪酸，是9-PAHSA 的活性代谢物。9-hydroxy Stearic Acid 是由9-PAHSA 通过肝脏和胰腺的羧基酯脂肪酶形成的。9-hydroxy Stearic Acid (5 μM)抑制HT-29结肠癌细胞裂解物中组蛋白去乙酰化酶1 (HDAC1)的表达。3 .当浓度为100 μM.1时，可抑制HT-29细胞的增殖，并诱导细胞周期阻滞于G0/ g1期。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T2S2215	Crebanine	Apoptosis; Others; Akt	Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	Crebanine 是来自于韦诺萨千金藤的一种生物碱，通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性，还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。
T16942	Sterigmatocystine	Others	Others
	Sterigmatocystine is an inhibitor of G1 Phase and DNA synthesis and is used to inhibit p21 activity. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor.
TMA0918	Neochamaejasmine A	Caspase	Apoptosis; Proteases/Proteasome
	Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating the p21 protein and ultimately pro
T75630	Ganoderic acid Mf	Others	Others
	Ganoderic acid Mf为具有抗肿瘤活性的三萜类化合物，能导致细胞周期在G1期停滞，并在正常细胞与癌细胞中显示高度选择性，通过线粒体介导途径促进细胞凋亡(apoptosis)。
T75621	Secalonic acid D	Others	Others
	Secalonic acid D 是一种抗肿瘤细胞的有毒化合物。Secalonic acid D 可以从Aspergillus aculeatus 的代谢产物中分离得到。Secalonic acid D 激活GSK3-β，并降解β-catenin。因此，Secalonic acid D 下调c-Myc 表达，使细胞周期停滞在 G1 期，诱导细胞凋亡 (apoptosis)。
T79971	Asparanin A	Apoptosis	Apoptosis
	Asparanin A 是一种具有抗癌活性的凋亡 (apoptosis) 诱导剂。它能够通过线粒体和 PI3K/AKT 信号通路使细胞周期在 G0/G1 期停滞，并有效抑制癌细胞生长。此外，Asparanin A 在小鼠Ishikawa子宫内膜癌异种移植模型中显示出显著的体内抑制肿瘤生长效力。
TN3719	Cristacarpin	p38 MAPK; ROS; CDK; Antifection; p53	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; Microbiology/Virology
	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s
TN7550	Bostrycin Rhodosporin	Others	Others
	Bostrycin, an anthraquinone derived from B. alpestre, exhibits a broad spectrum of biological activities including antibacterial, antiproliferative, and phytotoxic effects. This compound demonstrates efficacy against Gram-positive bacteria like methicillin-resistant S. aureus (MRSA), M. tuberculosis, and C. botulinum. Additionally, Bostrycin shows antiproliferative action against A549 lung adenocarcinoma cells, particularly by arresting the cell cycle at the G0/G1 phase and triggering apoptosis ...
TN3587	Capillarisin	MMP; ERK; IL Receptor; BCL; VEGFR; TNF; NOS; NF-κB; TLR; MAPK; COX; DNA/RNA Synthesis; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with
T36954	Nemorosone	Others	Others
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Cat.No: T3S1416

Synonym: Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素

Target: Apoptosis, PKC

Cat.No: T1882

Synonym: N-Methylisoindigotin,Methylisoindigotin,Natura-α,甲异靛,Dian III,异甲靛

Target: Apoptosis

Prim-O-glucosylcimifugin

Cat.No: T3805

Synonym: 升麻苷,Cimifugin beta-D-glucopyranoside,Cimifugin 7-glucoside

Target: TNF, COX, JAK, NO Synthase

Cat.No: T2996

Synonym: NSC-77037,d-Tetrandrine,Hanfangchin A,粉防己碱,Fanchinine,Sinomenine A,汉防己甲素

Target: Potassium Channel, Calcium Channel

Cat.No: TN1805

Target: Apoptosis, Androgen Receptor

trans-Nerolidol

Cat.No: T36473

Target: Antifungal

Perillyl alcohol

Cat.No: T3314

Synonym: Isocarveol,Perilla alcohol,紫苏醇

Target: Apoptosis, Endogenous Metabolite

Dracorhodin perchlorate

Cat.No: T2S2043

Synonym: Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate

Target: Apoptosis, Others

Cat.No: T3386

Synonym: Lespedin,Kaempferol,Lespenephryl,Lespenefril,Kaempferol 3,7-dirhamnoside,山奈苷

Target: cell cycle arrest, Glucokinase, IGF-1R

9-hydroxy Stearic Acid

Cat.No: T37067

Target: HDAC

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Cat.No: T2S2215

Target: Apoptosis, Others, Akt

Sterigmatocystine

Cat.No: T16942

Target: Others

Neochamaejasmine A

Cat.No: TMA0918

Target: Caspase

Ganoderic acid Mf

Cat.No: T75630

Target: Others

Secalonic acid D

Cat.No: T75621

Target: Others

Cat.No: T79971

Target: Apoptosis

Cat.No: TN3719

Target: p38 MAPK, ROS, CDK, Antifection, p53

Cat.No: TN7550

Synonym: Rhodosporin

Target: Others

Cat.No: TN3587

Target: MMP, ERK, IL Receptor, BCL, VEGFR, TNF, NOS, NF-κB, TLR, MAPK, COX, DNA/RNA Synthesis, Prostaglandin Receptor, JNK, STAT

Cat.No: T36954

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01308	GSPT1 Protein, Human, Recombinant (His & Myc) GSPT1,Eukaryotic peptide chain release factor GTP-binding su...	Human	P. pastoris (Yeast)
	Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ETF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. GSPT...
TMPY-04548	CDK4 Protein, Human, Recombinant (GST) CMM3,PSK-J3,cyclin-dependent kinase 4	Human	Baculovirus Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser...
TMPY-02543	PCNA Protein, Human, Recombinant (His) ATLD2,proliferating cell nuclear antigen	Human	Baculovirus Insect Cells
	Proliferating Cell Nuclear Antigen (PCNA) is a protein only expressed in normal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established functions for PCNA is its role as the processivity factor for DNA polymerase delta and epsilon. PCNA tethers the polymerase catalytic unit to the DNA template for rapid and processive DNA synthesis. Two forms of PCNA exist in cells: (i) a detergent-insoluble trimeric form stably associated with the replic...
TMPH-01658	MAGEA4 Protein, Human, Recombinant (His) MAGEA4,Melanoma-associated antigen 4,MAGE-4 antigen,MAGE-41 ...	Human	HEK293 Cells
	Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
TMPH-01659	MAGEA4 Protein, Human, Recombinant (A173T, His & Myc) MAGE-41 antigen,MAGE-4 antigen,Melanoma-associated antigen 4...	Human	E. coli
	Regulates cell proliferation through the inhibition of cell cycle arrest at the G1 phase. Also negatively regulates p53-mediated apoptosis.
TMPH-01526	KMT2E Protein, Human, Recombinant (His & Myc) Inactive histone-lysine N-methyltransferase 2E,Myeloid/lymph...	Human	E. coli
	Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle r...
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p33(CDK2)	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...
TMPJ-00502	Serpin G1 Protein, Human, Recombinant (His) C1-Inhibiting Factor,Serpin G1,SERPING1,C1...	Human	HEK293 Cells
	As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. Serpin G1 is a serine protease inhibitor protein. It is the largest member among the serpin class of proteins. Remarkably, Serpin G1 has a 2-domain structure, unlike most family members. The C-terminal serpin domain is similar to other serpins, and this part of Serpin G1 provides the inhibitory activity. The N-terminal domain ...
TMPK-00015	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) GROES,Hsp10,Chaperonin 10,HSPE1,EPF,CPN10	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi) is expressed in E. coli expression system w...
TMPK-00016	Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated Hsp10,Chaperonin 10,HSPE1,GROES,EPF,Cpn10	Human,Mouse,Goat	E. coli
	Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT. A pool of Cpn10 is colocalized with NPAT foci during G1 and S phases in nuclei.Cpn10 is important for S phase progression and cell proliferation. Interaction of Heat Shock Protein Cpn10 with the Cyclin E/Cdk2 Substrate Nuclear Protein Ataxia-Telangiectasia (NPAT) Is Involved in Regulating Histone Transcription. Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated is expressed in E. coli expre...
TMPJ-00053	PRL-2 Protein, Human, Recombinant (His) HU-PP-1,Protein tyrosine phosphatase type IVA 2,OV-1,PTP4A2,...	Human	E. coli
	PTP4A2, also known as PRL2 or PTPCAAX2, is short for Protein tyrosine phosphatase type IVA 2. This protein exists in cell membrane, cytoplasm,endosome and membrane. PTP4A2 is often farnesylated during post-translational modification. Farnesylation is required for membrane targeting and for interaction with RABGGTB. The unfarnesylated forms are redirected to the nucleus and cytosol. It can stimulate progression from G1 into S phase during mitosis and promotes tumors. It also inhibits geranylgeran...
TMPJ-00936	CCND2 Protein, Human, Recombinant (His) G1/S-specific cyclin-D2,CCND2	Human	E. coli
	CCND2，also known as G1/S-specific cyclin-D2，is a member of the highly conserved cyclin family. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND2 is involved in a number of fundamental biological processes such ...
TMPJ-00721	ZBED1 Protein, Human, Recombinant (His) TRAMP,dREF Homolog,ALTE,DREF,ZBED1,Zinc Finger BED Domain-Co...	Human	E. coli
	Zinc Finger BED Domain-Containing Protein 1 (ZBED1) contains one BED-type zinc finger and is found in the cell nucleus. ZBED1 is widely expressed, highly in heart, skeletal muscle, spleen and placenta. The expression of ZBED1 is usually linked to the cell cycle. During the G1/S phase, the expression is increasing. During the S/G2 phage, the expression reaches to the highest, and then decreasing. ZBED1 exists in homodimer forms, which can bind to 5’-TGTCCG[CT]GA[CT]A-3’ DNA elements, that can be ...
TMPJ-00948	Endostatin Protein, Mouse, Recombinant (His) antiangiogenic agent,type XVIII,collagen α-1(XVIII)chain,col...	Mouse	HEK293 Cells
	Endostatin, an endogenous non‑glycosylated inhibitor of endothelial cell proliferation and angiogenesis. It is produced and/or trimmed by metalloproteinases such as MMP‑2 and MMP‑9, and cathepsins S, B and L. The N‑terminal ~27 aa of Endostatin appear to contain the majority of its activity. This region contains zinc binding sites that are thought to be critical for its anti‑endothelial and anti‑tumor effects, as well as multiple cleavage sites that, when used, can modify its activity. Mouse End...
TMPJ-01178	TGFBR1 Protein, Mouse, Recombinant (hFc) ALK-5,ALK-5ALK5,TGFβRI,tβR-I,LDS1A,TGFbetaRI,TGFB1R1,activin...	Mouse	HEK293 Cells
	TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Phosphorylated TGF-beta RI can then transiently bind and phosphorylate Smad2 and Smad3. TGF-beta functions as a tumor suppressor by inhibiting the cell cycle in the G1 phase. Administration of TGF-beta is able to protect against mammary tumor development in transgenic mouse models i...

重组蛋白

GSPT1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01308

Species: Human

Expression System: P. pastoris (Yeast)

CDK4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04548

Species: Human

Expression System: Baculovirus Insect Cells

PCNA Protein, Human, Recombinant (His)

Cat.No: TMPY-02543

Species: Human

Expression System: Baculovirus Insect Cells

MAGEA4 Protein, Human, Recombinant (His)

Cat.No: TMPH-01658

Species: Human

Expression System: HEK293 Cells

MAGEA4 Protein, Human, Recombinant (A173T, His & Myc)

Cat.No: TMPH-01659

Species: Human

Expression System: E. coli

KMT2E Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01526

Species: Human

Expression System: E. coli

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

Serpin G1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00502

Species: Human

Expression System: HEK293 Cells

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi)

Cat.No: TMPK-00015

Species: Human,Mouse,Goat

Expression System: E. coli

Cpn10/HSPE1 Protein, Human/Mouse/Goat, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00016

Species: Human,Mouse,Goat

Expression System: E. coli

PRL-2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00053

Species: Human

Expression System: E. coli

CCND2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00936

Species: Human

Expression System: E. coli

ZBED1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00721

Species: Human

Expression System: E. coli

Endostatin Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00948

Species: Mouse

Expression System: HEK293 Cells

TGFBR1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-01178

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0050	Butyricacid-d7
	Butyricacid-d7 是 Butyricacid 的氘代化合物。Butyricacid 的 CAS 号为 107-92-6。Butyric acid 是一种从许多乳制品中分离出来的脂肪酸，具有抗癌活性。它抑制组蛋白去乙酰化酶 (HDAC) 并诱导胶质瘤细胞凋亡和 G1 期细胞周期停滞。此外，它在低剂量时刺激上皮细胞增殖，在高剂量时抑制增殖。

同位素标记化合物

Cat.No: TMIJ-0050

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