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240

抑制剂 & 化合物

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化合物库

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Cat. No. Product Name
L2140 癌细胞分化化合物库

406 compounds
406 个诱导肿瘤细胞分化化合物的独特集合,可用于高通量筛选和高内涵筛选;

化合物库

癌细胞分化化合物库
Cat.No: L2140
Compounds: 406
Cat. No. Product Name Target Signaling Pathways
T83738 SMAP 29 (ovine) TFA

Sheep Myeloid Antimicrobial Peptide 29

SMAP 29是一种抗微生物肽,同时也是绵羊防御素前体肽的C末端切割产物。在低盐和高盐条件下,对P. aeruginosa菌株PAO1具有杀菌作用,该作用在能量依赖的发光测定中表现出来(EC50s分别为0.05和0.06 µM)。它还能够以浓度依赖的方式引起绵羊红细胞的溶血。
T83706 BMAP 28 (bovine) TFA

Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28

BMAP 28是一种合成抗菌肽,对应牛防御素-5的132-158氨基酸。对大肠杆菌(E. coli)、金黄色葡萄球菌(S. aureus)、耐甲氧西林金黄色葡萄球菌(MRSA)、表皮葡萄球菌(S. epidermidis)及白色念珠菌(C. albicans)具有活性(MICs分别为2、2、4、1和8 µM)。在200 nM浓度下,BMAP 28能够使大肠杆菌的内膜渗透。在5 µM浓度下,减少Vero 76细胞中单纯疱疹病毒1型(HSV-1)的复制。在30 µM浓度下,对分离的人类红细胞引起溶血,并对分离的人类嗜中性粒细胞具有细胞毒性。BMAP 28 (0.8 mg/kg)可提高大肠杆菌或MRSA感染的小鼠的生存率,但对铜绿假单胞菌(P. aeruginosa)感染的小鼠无效。
T9919 Alemtuzumab

Others Others
Alemtuzumab 是人源化抗 CD52单克隆抗体, CD52是一种表达于大多数淋巴细胞以及少数的髓细胞类型的糖蛋白。Alemtuzumab 与能够特异性作用于 CD52 抗原,诱导淋巴细胞深度耗竭,恢复具有调节表型的 T 细胞和 B 细胞。
T12253 Nrf2-IN-1

Others; Nrf2 Immunology/Inflammation; Others
Nrf2-IN-1 是 Nrf2抑制剂,可用于研究急性髓性白血病药物。
T9060 STM2457

Apoptosis; Others Apoptosis; Others
STM2457 是一种 RNA 甲基转移酶 METTL3 的抑制剂 (IC50=16.9 nM),具有选择性和口服活性。STM2457 可用于急性髓系白血病 (AML) 的研究。
T13774 ML390

Others; Dehydrogenase Metabolism; Others
ML390 是二氢乳清酸脱氢酶抑制剂。他是骨髓分化的诱导剂,能够引起鼠 (ER-HoxA9) 以及人 (U937 and THP1) 急性髓细胞性白血病 (AML) 细胞发生骨髓分化。
T13950 UC-514321

Apoptosis; STAT Apoptosis; JAK/STAT signaling; Stem Cells
UC-514321 是NSC370284 的结构类似物,靶向STAT3/5并选择性抑制TET1的表达,且活性更高。它有较低的毒性,在体内外均表现出良好的抗急性髓系白血病活性。
T12943 SNDX-5613

Epigenetic Reader Domain; Histone Methyltransferase Chromatin/Epigenetic
SNDX-5613 是一种 Menin-MLL 特异性抑制剂,Ki 为 0.149 nM,IC50 为 10 在 20 nM 之间,可用于 MLL 基因重排的急性白血病研究。
T83698 Cathelicidin-2 (128-153) (chicken) TFA

Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153)

Cathelicidin-2 (CATH-2) (128-153) 是一种合成抗菌肽,对应于鸡CATH-2的128至153个氨基酸。该化合物对E. coli、S. aureus、S. enteritidis和B. globigii展示出浓度依赖性的活性。CATH-2 (128-153) (40 µM) 可诱导孤立的鸡红细胞溶解,但对孤立的人外周血单个核细胞(PBMCs)无细胞毒性。它能促进化学因子(C-C-基序)配体2 (CCL2)的产生,并抑制LPS诱导的TNF-α、IL-6、IL-8和IL-10在孤立的人PBMCs中的产生。
T9041 AES-350

Apoptosis; HDAC Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
AES-350 是一种具有口服活性HDAC6抑制剂,IC50和Ki 分别为 0.0244 μM 和 0.035 μM。它对 HDAC3、8 和 11 的 IC50值分别为 0.187、0.245和大于1μM。它通过抑制 HDAC 诱导 AML 细胞凋亡,可研究急性髓系白血病。
T7138 FB23-2

Apoptosis; Others Apoptosis; Others
FB23-2 是一种 mRNA N6- 甲基腺嘌呤脱甲基酶 FTO 选择性抑制剂,IC50值为 2.6 μM。它具有抗增殖作用,可研究急性髓系白血病。
T8882 Vodobatinib

K-0706

Bcr-Abl Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
Vodobatinib (K-0706) 是第三代具有口服活性的Bcr-Abl1酪氨酸激酶抑制剂,IC50=7 nM,对大多数 BCR-ABL1 点突变体具有活性,但对 BCR-ABL1T315I 无活性。它可用于研究慢性粒细胞白血病 (CML)。
T64338 AKI603

AKI 603,AKI-603

Aurora Kinase Cell Cycle/Checkpoint; Chromatin/Epigenetic
AKI603 是一种极光激酶 A 抑制剂,IC50值为 12.3 nM。它对白血病细胞具有很强的抗增殖活性,可用于克服白血病中 BCR-ABL-T315I 耐药性突变。
T9765 TJ-M2010-5

MyD88 Immunology/Inflammation
TJ-M2010-5 是一种 MyD88 抑制剂,可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-5 可用于心肌缺血/再灌注损伤研究。
T24269 KPT-251

KPT251

Others Others
KPT-251 是一种选择性核输出抑制剂。
T11344 G150

DNA; cGAS DNA Damage/DNA Repair; Immunology/Inflammation
G150 是高选择性h-cGAS 抑制剂,IC50值为 10.2 nM,用于抑制 dsDNA 引发的干扰素表达。
T8497 SX-682

CXCR Autophagy; GPCR/G Protein; Immunology/Inflammation
SX-682 是口服有效的 CXCR1和 CXCR2变构抑制剂,可以阻断肿瘤髓系抑制细胞募集并增强 T 细胞活化和抗肿瘤免疫,具有治疗去势抵抗性前列腺癌的潜力。
T9014 SKI-178

Apoptosis; S1P Receptor Apoptosis; GPCR/G Protein
SKI-178 是一种鞘氨醇激酶-1(SphK1)和 SphK2抑制剂,以 CDK1 依赖性方式诱导人急性髓性白血病细胞凋亡。
T16557 PNU-159682

Topoisomerase; ADC Cytotoxin Antibody-drug Conjugate/ADC Related; DNA Damage/DNA Repair
PNU-159682 是蒽环类新霉素的代谢产物,是一种 DNA 拓扑异构酶 II 抑制剂,具有出色的细胞毒性。
T10606 BRD0705

GSK-3 PI3K/Akt/mTOR signaling; Stem Cells
BRD0705 是一种具有旁系选择性的、口服具有活性的GSK3α抑制剂,其 IC50=66 nM,Kd=4.8 μM。 它与 GSK3β (其 IC50=515 nM) 相比,对GSK3α的选择性更高 (8 倍)。它可用于研究急性髓细胞性白血病。
T14919 CDKI-73

Apoptosis; CDK Apoptosis; Cell Cycle/Checkpoint
CDKI-73 是一种具有口服活性的 CDK9抑制剂,其对 CDK9、CDK1 和 CDK2 的Ki 值分别为 4 nM、4 nM 和 3 nM。CDKI-73 可下调 RNA 聚合酶 II 的磷酸化。CDKI-73 也是一种 Rab11 的抑制剂。
T9705 TL-895

BTK Angiogenesis; Tyrosine Kinase/Adaptors
TL-895 是口服有效的,ATP 竞争性的,以及高度选择性和不可逆的BTK 抑制剂,IC50和Ki 分别为 1.5 nM 和 11.9 nM。TL-895在 JAKi 复发/难治性骨髓纤维化、急性髓系白血病、COVID-19 和癌症方面有研究的价值。
T38562 AKN-028

FLT Angiogenesis; Tyrosine Kinase/Adaptors
AKN-028 是酪氨酸激酶 FLT3的抑制剂,可剂量依赖性的诱导 FLT3的自磷酸化。
T2620 G-749

G749

Apoptosis; FLT; c-RET; TAM Receptor; Aurora Kinase Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors
G-749 是一种新型 FLT3 抑制剂,对 FLT3 野生型和突变体有持续的抑制作用,IC50值分别为 0.4 nM 和 0.6 nM。它可用于急性髓系白血病的耐药研究。
T22553 Adaphostin

1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410

Bcr-Abl Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
Adaphostin (NSC-680410) 是 AG957 金刚烷酯,是一种 p210bcr/abl 抑制剂,可诱导 T 淋巴细胞白血病细胞系凋亡。它增加了 CLL B 细胞内活性氧的水平,对慢性和急性髓系白血病细胞具有显著的选择性活性。
T8978 DD1

3,3'-Diamino-4'-methoxyflavone,HUN85111

Proteasome Proteases/Proteasome; Ubiquitination
DD1 (HUN85111) 是一种蛋白酶体抑制剂,可诱导人髓系肿瘤选择性凋亡。
T28475 Pyrazoloacridine

PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934

Apoptosis; Topoisomerase Apoptosis; DNA Damage/DNA Repair
Pyrazoloacridine (PD 115934) 是一种核酸结合剂,在 K562 细胞中抑制 topo I 和 II 的活性,IC50 为 1.25 μM。 Pyrazoloacridine 具有抗癌活性。
T10384 Farudodstat

ASLAN003

Apoptosis; Dehydrogenase; DNA/RNA Synthesis Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
Farudodstat (ASLAN003) 是一种具有口服活性的二氢乳清酸脱氢酶 (DHODH) 抑制剂,对人 DHODH 酶的IC50为 35 nM。它通过激活 AP-1 转录因子来抑制蛋白质合成,可以诱导凋亡,并在急性髓样白血病异种移植小鼠中大大延长其生存期。
T1979 AVN-944

VX-944

Dehydrogenase Metabolism
AVN-944 (VX-944) 是一种选择性的、非竞争性 IMPDH 抑制剂,对IMPDH1和IMPDH2的Ki=为6-10nM。
T16028 IMB-XH1

Mcl1-IN-2,7-[(2-吡啶基氨基)-2-噻吩基甲基]-8-喹啉醇

BCL; Antibacterial Apoptosis; Microbiology/Virology
IMB-XH1 (Mcl1-IN-2) 是一种骨髓细胞因子 1 抑制剂。它也是非竞争性的 Delhi metallo-β-lactamase(NDM-1) 抑制剂。它对金属 β-内酰胺酶 NDM-1,IMP-4,ImiS 和 L1 的 IC50值分别为 0.4637 μM,3.980 μM,0.2287 μM 和 1.158 μM。
T3184 Kevetrin hydrochloride

Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride

Mdm2; p53 Apoptosis
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) 是一种小分子,是肿瘤抑制蛋白 p53 的激活剂,具有潜在的抗肿瘤活性。
T2066 Quizartinib

AC220,奎扎替尼

Apoptosis; FLT; Autophagy; Ligands for Target Protein for PROTAC Angiogenesis; Apoptosis; Autophagy; PROTAC; Tyrosine Kinase/Adaptors
Quizartinib (AC220) 是一种第二代 Ⅱ 型 FLT3 酪氨酸激酶抑制剂,具有口服活性和高选择性,抑制 FLT3-WT 和 FLT3-ITD 自磷酸化 (IC50=4.1/1.1 nM)。Quizartinib 可以诱导肿瘤细胞凋亡。
T0942 Quinacrine dihydrochloride

疟疾平,Mepacrine dihydrochloride,阿的平,SN-390,Quinacrine 2HCl

Apoptosis; Mitophagy; DNA; Phospholipase; Parasite; Autophagy; Histamine Receptor Apoptosis; Autophagy; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
Quinacrine dihydrochloride (Mepacrine dihydrochloride) 是一种具有口服活性的抗疟剂,抑制 NF-κB 并激活 p53 信号转导,诱导肿瘤细胞发生凋亡,具有抗肿瘤和抗寄生虫活性。
T2346L Enasidenib mesylate

AG221 mesylate,AG 221 mesylate,恩西地平甲磺酸盐,AG-221 mesylate

Dehydrogenase Metabolism
Enasidenib mesylate (AG-221 mesylate) 是一种具有有效性和选择性的 IDH2 突变酶抑制剂,可促进白血病成髓细胞的分化,可用于治疗急性髓系白血病。
T25006 AGI-14100

AGI 14100

Dehydrogenase Metabolism
AGI-14100 是一种新型且可口服的 mIDH1 抑制剂。AGI-14100 用于治疗原发性人类髓性白血病。
T12629L MIK665

S-64315

BCL Apoptosis
MIK665 (S-64315) (S-64315) 对髓系细胞白血病具有抑制作用。
T27299 F-14512

F14512

Topoisomerase DNA Damage/DNA Repair
F-14512 (free base) 是一种拓扑异构酶II抑制剂,可用于研究急性髓性白血病。
T12041 MIM1

Inhibitor of Mcl-1

BCL Apoptosis
MIM1 (Inhibitor of Mcl-1) 是一种骨髓细胞因子 1 抑制剂。
T4231 MD2-IN-1

TLR Immunology/Inflammation
MD2-IN-1 是骨髓分化蛋白 2 (MD2) 的抑制剂,对重组人 MD2 (rhMD2) 的 KD 为 189  μM。
TQ0245 Sapacitabine

CS682,CYC682

Nucleoside Antimetabolite/Analog Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Sapacitabine (CS682) 是一种可口服的核苷类似物前体化合物,具有潜在的抗肿瘤活性,可用于研究急性髓系白血病。
T31088 CPX-351

CPX 351,Vyxeos,CPX351

Others Others
CPX-351 (Vyxeos) 是阿糖胞苷和柔红霉素的脂质体封装物,具有潜在的抗肿瘤活性,可用与研究急性髓系白血病。
T14501 BAY-2402234

Dehydrogenase; DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
BAY-2402234 是一种选择性二氢乳清酸脱氢酶的抑制剂,可研究骨髓恶性肿瘤。
T3099 Pinometostat

EPZ-5676

Histone Methyltransferase Chromatin/Epigenetic
Pinometostat (EPZ-5676) 是有效的DOT1L 组蛋白甲基转移酶抑制剂,Ki 为 80 pM。它可用于研究多种白血病治疗的实验。
T6857 HLCL-61 hydrochloride

HLCL61,HLCL-61 HCL

Apoptosis; Histone Methyltransferase Apoptosis; Chromatin/Epigenetic
HLCL-61 hydrochloride (HLCL-61 HCL) 是小分子蛋白精氨酸甲基转移酶 5 抑制剂。
T9749 FHD-286

Epigenetic Reader Domain Chromatin/Epigenetic
FHD-286 是 BRM/BRG1 ATPase 的抑制剂,可用于治疗 BAF 相关疾病如急性髓性白血病的研究。
T62750 TREM2 agonist-2

Others Others
TREM2 agonist-2 (I-192) 是一种具有口服活性和高效性的髓系细胞触发受体 2 (TREM2) 激动剂 ,可用于研究神经退行性疾病。
T83966 LSD1-IN-30

Histone Demethylase Chromatin/Epigenetic
LSD1-IN-30 是赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂,具有抗癌活性,可用于研究小细胞肺癌和急性髓细胞白血病。
T27488 GSK-690

GSK 690,GSK690

Histone Demethylase Chromatin/Epigenetic
GSK-690 是一种具有选择性和高效性的赖氨酸去甲基化酶1 (LSD 1) 抑制剂,可诱导急性髓系白血病 (AML) 中白血病干细胞的分化,可用于研究白血病。
T7776 ADH-503

GB1275

Complement System Immunology/Inflammation
ADH-503 (GB1275) 是一种可口服的变构CD11b 激动剂,可以导致与肿瘤相关的巨噬细胞重新极化,可减轻骨髓细胞的免疫抑制,并增强树突状细胞的反应。
T8871 C/EBPα inducer 1

4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-

Others Others
C/EBPα inducer 1 (4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-) 是一种C/EBPα和骨髓细胞分化的诱导剂。

化合物

SMAP 29 (ovine) TFA
Cat.No: T83738
Synonym: Sheep Myeloid Antimicrobial Peptide 29
Target:
BMAP 28 (bovine) TFA
Cat.No: T83706
Synonym: Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28
Target:
Alemtuzumab
Cat.No: T9919
Synonym:
Target: Others
Nrf2-IN-1
Cat.No: T12253
Synonym:
Target: Others, Nrf2
STM2457
Cat.No: T9060
Synonym:
Target: Apoptosis, Others
ML390
Cat.No: T13774
Synonym:
Target: Others, Dehydrogenase
UC-514321
Cat.No: T13950
Synonym:
Target: Apoptosis, STAT
SNDX-5613
Cat.No: T12943
Synonym:
Target: Epigenetic Reader Domain, Histone Methyltransferase
Cathelicidin-2 (128-153) (chicken) TFA
Cat.No: T83698
Synonym: Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153)
Target:
AES-350
Cat.No: T9041
Synonym:
Target: Apoptosis, HDAC
FB23-2
Cat.No: T7138
Synonym:
Target: Apoptosis, Others
Vodobatinib
Cat.No: T8882
Synonym: K-0706
Target: Bcr-Abl
AKI603
Cat.No: T64338
Synonym: AKI 603,AKI-603
Target: Aurora Kinase
TJ-M2010-5
Cat.No: T9765
Synonym:
Target: MyD88
KPT-251
Cat.No: T24269
Synonym: KPT251
Target: Others
G150
Cat.No: T11344
Synonym:
Target: DNA, cGAS
SX-682
Cat.No: T8497
Synonym:
Target: CXCR
SKI-178
Cat.No: T9014
Synonym:
Target: Apoptosis, S1P Receptor
PNU-159682
Cat.No: T16557
Synonym:
Target: Topoisomerase, ADC Cytotoxin
BRD0705
Cat.No: T10606
Synonym:
Target: GSK-3
CDKI-73
Cat.No: T14919
Synonym:
Target: Apoptosis, CDK
TL-895
Cat.No: T9705
Synonym:
Target: BTK
AKN-028
Cat.No: T38562
Synonym:
Target: FLT
G-749
Cat.No: T2620
Synonym: G749
Target: Apoptosis, FLT, c-RET, TAM Receptor, Aurora Kinase
Adaphostin
Cat.No: T22553
Synonym: 1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410
Target: Bcr-Abl
DD1
Cat.No: T8978
Synonym: 3,3'-Diamino-4'-methoxyflavone,HUN85111
Target: Proteasome
Pyrazoloacridine
Cat.No: T28475
Synonym: PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934
Target: Apoptosis, Topoisomerase
Farudodstat
Cat.No: T10384
Synonym: ASLAN003
Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis
AVN-944
Cat.No: T1979
Synonym: VX-944
Target: Dehydrogenase
IMB-XH1
Cat.No: T16028
Synonym: Mcl1-IN-2,7-[(2-吡啶基氨基)-2-噻吩基甲基]-8-喹啉醇
Target: BCL, Antibacterial
Kevetrin hydrochloride
Cat.No: T3184
Synonym: Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride
Target: Mdm2, p53
Quizartinib
Cat.No: T2066
Synonym: AC220,奎扎替尼
Target: Apoptosis, FLT, Autophagy, Ligands for Target Protein for PROTAC
Quinacrine dihydrochloride
Cat.No: T0942
Synonym: 疟疾平,Mepacrine dihydrochloride,阿的平,SN-390,Quinacrine 2HCl
Target: Apoptosis, Mitophagy, DNA, Phospholipase, Parasite, Autophagy, Histamine Receptor
Enasidenib mesylate
Cat.No: T2346L
Synonym: AG221 mesylate,AG 221 mesylate,恩西地平甲磺酸盐,AG-221 mesylate
Target: Dehydrogenase
AGI-14100
Cat.No: T25006
Synonym: AGI 14100
Target: Dehydrogenase
MIK665
Cat.No: T12629L
Synonym: S-64315
Target: BCL
F-14512
Cat.No: T27299
Synonym: F14512
Target: Topoisomerase
MIM1
Cat.No: T12041
Synonym: Inhibitor of Mcl-1
Target: BCL
MD2-IN-1
Cat.No: T4231
Synonym:
Target: TLR
Sapacitabine
Cat.No: TQ0245
Synonym: CS682,CYC682
Target: Nucleoside Antimetabolite/Analog
CPX-351
Cat.No: T31088
Synonym: CPX 351,Vyxeos,CPX351
Target: Others
BAY-2402234
Cat.No: T14501
Synonym:
Target: Dehydrogenase, DNA/RNA Synthesis
Pinometostat
Cat.No: T3099
Synonym: EPZ-5676
Target: Histone Methyltransferase
HLCL-61 hydrochloride
Cat.No: T6857
Synonym: HLCL61,HLCL-61 HCL
Target: Apoptosis, Histone Methyltransferase
FHD-286
Cat.No: T9749
Synonym:
Target: Epigenetic Reader Domain
TREM2 agonist-2
Cat.No: T62750
Synonym:
Target: Others
LSD1-IN-30
Cat.No: T83966
Synonym:
Target: Histone Demethylase
GSK-690
Cat.No: T27488
Synonym: GSK 690,GSK690
Target: Histone Demethylase
ADH-503
Cat.No: T7776
Synonym: GB1275
Target: Complement System
C/EBPα inducer 1
Cat.No: T8871
Synonym: 4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-
Target: Others
Cat. No. Product Name Target Signaling Pathways
T6S1435 Notopterol

Apoptosis; Others Apoptosis; Others
Notopterol 是从羌活提取的一种香豆素,可诱导细胞凋亡,具有解热、缓解疼痛和抗炎作用。它有用于急性髓细胞性白血病的潜力。
T1882 Meisoindigo

N-Methylisoindigotin,Methylisoindigotin,Natura-α,甲异靛,Dian III,异甲靛

Apoptosis Apoptosis
Meisoindigo (Natura-α) 是 Indirubin 的衍生物,可以造成急性髓细胞性白血病细胞周期在 G0/G1 期停滞,并诱导凋亡,具有高抗肿瘤活性。
T34398 Rotundifuran

Others Others
Rotundifuran 是从 Vitex rotundifolia 的果实中提取的。 Rotundifuran 抑制细胞周期进程并诱导人髓性白血病细胞凋亡。
T11060 DMAPT

Dimethylamino Parthenolide

NF-κB NF-κB
DMAPT (Dimethylamino Parthenolide) 是一种具有口服活性的NF-κB 抑制剂,是一种 Parthenolide (PTL) 的类似物,对原发性急性髓性白血病细胞的LD50值为1.7 μM。具有潜在的抗肿瘤和抗转移作用。
TN1369 Alloimperatorin

Prangenidin,别欧前胡素

Others Others
Alloimperatorin (Prangenidin) 是一种从Angelica dahurica 的提取得到的香豆素类化合物,具有抗肿瘤作用。
T4036 Solasodine

Solancarpidine,Purapuridine,澳洲茄铵,Solasodin

Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal Apoptosis; Microbiology/Virology; Others; Ubiquitination
Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。
TN1215 (2S)-2'-Methoxykurarinone

2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone

Akt; Antifection Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
(2S)-2'-Methoxykurarinone 是一种分离自苦参根中的化合物,具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号,抑制破骨细胞形成和骨吸收。
T3733 (E)-Methyl 4-coumarate

Methyl trans-p-Coumarat,OMpCA,反式对羟基肉桂酸,Methyl 4-hydroxycinnamate

Apoptosis; Others; Antibacterial Apoptosis; Microbiology/Virology; Others
Methyl (E)-4-hydroxycinnamatee在几种植物中发现,如洋葱或海巴戟叶中。它与 Carnosic Acid 联用可诱导细胞凋亡,杀死急性髓性白血病细胞。它具有抗氧化和抗菌活性。
T4S1943 Kirenol

奇壬醇,奇任醇,Kirel

Wnt/beta-catenin Cytoskeletal Signaling; Stem Cells
Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的,具有抗氧化、抗炎、抗过敏、抗关节炎活性,可用于缓解疼痛的研究。
TN2211 Silybin B

Silibinin B

Apoptosis; Beta Amyloid; Bcr-Abl Angiogenesis; Apoptosis; Cytoskeletal Signaling; Neuroscience; Tyrosine Kinase/Adaptors
Silybin B (Silibinin B) 是雷洛昔芬4′-和6-葡萄糖醛酸化的有效抑制剂,是水飞蓟素有效的抗纤维原性和抗低聚物成分,具有清除1,1-二苯基-2-吡啶酰肼(DPPH)自由基的活性 ,可通过减轻 DNA 损伤和细胞凋亡对顺铂诱导的神经毒性具有保护作用。Silybin B 对人慢性髓系白血病 K562细胞的生长抑制和诱导凋亡有较强的作用。
TN5585 14-Deoxy-11-hydroxyandrographolide

14-Deoxy-11-hydroxyandrographolide shows potent cell differentiation-inducing activity towards mouse myeloid leukemia (M1) cells.
T80259 PMAP-23

Others Others
PMAP-23为具有生物活性的抗菌肽(AMP),源自猪骨髓。
TN5593 Euphohelioscopin A

Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it exhibits moderate inhibitory activity
T36417 Nargenicin

Antibiotic 47444

Others Others
Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (...

天然产物

Notopterol
Cat.No: T6S1435
Synonym:
Target: Apoptosis, Others
Meisoindigo
Cat.No: T1882
Synonym: N-Methylisoindigotin,Methylisoindigotin,Natura-α,甲异靛,Dian III,异甲靛
Target: Apoptosis
Rotundifuran
Cat.No: T34398
Synonym:
Target: Others
DMAPT
Cat.No: T11060
Synonym: Dimethylamino Parthenolide
Target: NF-κB
Alloimperatorin
Cat.No: TN1369
Synonym: Prangenidin,别欧前胡素
Target: Others
Solasodine
Cat.No: T4036
Synonym: Solancarpidine,Purapuridine,澳洲茄铵,Solasodin
Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal
(2S)-2'-Methoxykurarinone
Cat.No: TN1215
Synonym: 2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone
Target: Akt, Antifection
(E)-Methyl 4-coumarate
Cat.No: T3733
Synonym: Methyl trans-p-Coumarat,OMpCA,反式对羟基肉桂酸,Methyl 4-hydroxycinnamate
Target: Apoptosis, Others, Antibacterial
Kirenol
Cat.No: T4S1943
Synonym: 奇壬醇,奇任醇,Kirel
Target: Wnt/beta-catenin
Silybin B
Cat.No: TN2211
Synonym: Silibinin B
Target: Apoptosis, Beta Amyloid, Bcr-Abl
14-Deoxy-11-hydroxyandrographolide
Cat.No: TN5585
Synonym:
Target:
PMAP-23
Cat.No: T80259
Synonym:
Target: Others
Euphohelioscopin A
Cat.No: TN5593
Synonym:
Target:
Nargenicin
Cat.No: T36417
Synonym: Antibiotic 47444
Target: Others
Cat. No. Product Name Species Expression System
TMPY-01774 TREM-1 Protein, Human, Recombinant (His)

TREM-1,triggering receptor expressed on myeloid cel...

Human HEK293 Cells
TREM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is Q38L15.
TMPY-01703 TREM-2 Protein, Mouse, Recombinant (His)

Trem2b,TREM-2,Trem2c,triggering receptor expressed on my...

Mouse HEK293 Cells
TREM-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is Q99NH8-1.
TMPY-01148 TREM-2 Protein, Human, Recombinant (His)

TREM-2,Trem2b,triggering receptor expressed on myeloid

Human HEK293 Cells
TREM-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.9 kDa and the accession number is Q5TCX1.
TMPY-00432 TREM-2 Protein, Mouse, Recombinant (hFc)

triggering receptor expressed on myeloid cells 2,Tr...

Mouse HEK293 Cells
TREM-2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.4 kDa and the accession number is Q99NH8-1.
TMPY-01648 TREML2 Protein, Human, Recombinant (His)

TLT2,dJ238O23.1,triggering receptor expressed on myeloid...

Human HEK293 Cells
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune respons...
TMPY-06527 TREM-1 Protein, Mouse, Recombinant (His)

triggering receptor expressed on myeloid cells 1

Mouse HEK293 Cells
TREM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.57 kDa and the accession number is Q9JKE2-1.
TMPH-01723 MYD88 Protein, Human, Recombinant (His)

Myeloid differentiation primary response protein My...

Human E. coli
MYD88 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.2 kDa and the accession number is Q99836.
TMPY-00943 TREM-1 Protein, Human, Recombinant (His & hFc)

TREM-1,triggering receptor expressed on myeloid cel...

Human HEK293 Cells
TREM-1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 48.3 kDa and the accession number is Q38L15.
TMPH-03100 PMAP-23 Protein, Pig, Recombinant (His & SUMO)

PMAP23,Antibacterial peptide PMAP-23,Myeloid antiba...

Sus scrofa (Pig) E. coli
Exerts antimicrobial activity against both Gram-positive and negative bacteria at concentrations of 2-16 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes. PMAP-23 Protein, Pig, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 19.0 kDa and the accession number is P49930.
TMPY-06598 TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated

TREM-2,Trem2a,Trem2c,triggering receptor expressed on my...

Human HEK293 Cells
TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 20.69 kDa and the accession number is NP_061838.1.
TMPY-04264 SF20 Protein, Human, Recombinant (mFc)

IL27,EUROIMAGE1875335,myeloid-derived growth factor...

Human HEK293 Cells
SF20 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.2 kDa and the accession number is Q969H8.
TMPY-00034 SF20 Protein, Human, Recombinant (His)

myeloid-derived growth factor,R33729_1,IL25,IL27w,S...

Human HEK293 Cells
SF20 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.3 kDa and the accession number is Q969H8.
TMPY-06566 TREM-2 Protein, Human, Recombinant (hFc)

Trem2b,TREM-2,Trem2a,Trem2c,triggering receptor expressed on...

Human HEK293 Cells
TREM-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.16 kDa and the accession number is NP_061838.1.
TMPH-00230 Cathelicidin-6 Protein, Bovine, Recombinant (His & SUMO)

CATHL6,Antibacterial peptide BMAP-27,Myeloid antiba...

Bovine E. coli
Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. Cathelicidin-6 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 16.2 kDa and the accession number is P54228.
TMPJ-00115 TREM-2 Protein, Human, Recombinant (Avi & His), Biotinylated

Triggering receptor expressed on monocytes 2,Triggering rece...

Human HEK293 Cells
TREM-2 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is Q9NZC2.
TMPJ-00117 TREM-2 Protein, Human, Recombinant (mFc)

Triggering receptor expressed on myeloid cells 2,Tr...

Human HEK293 Cells
TREM-2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 50-65 KDa and the accession number is Q9NZC2.
TMPH-01526 KMT2E Protein, Human, Recombinant (His & Myc)

Inactive histone-lysine N-methyltransferase 2E,Myeloid

Human E. coli
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle r...
TMPJ-00537 Siglec-3/CD33 Protein, Human, Recombinant (hFc & His)

Myeloid Cell Surface Antigen CD33,CD33,Siglec-3,SIG...

Human HEK293 Cells
CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are c...
TMPJ-00589 TREML2 Protein, Human, Recombinant (hFc)

C6orf76,TLT2,Triggering receptor expressed on myeloid

Human HEK293 Cells
TREML2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 80-110 KDa and the accession number is AAI25079.1.
TMPH-01106 CD300LB Protein, Human, Recombinant (His)

CMRF35-like molecule 7,CD300LB,CMRF35A2,CD300b,TREM-5,Leukoc...

Human E. coli
Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. CD300LB Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 18.8 kDa and the accession number is A8K4G0.
TMPJ-00193 TREML1 Protein, Human, Recombinant (hFc)

TLT-1,Trem-Like Transcript 1 Protein,TLT1,Triggering Recepto...

Human HEK293 Cells
Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-like V-type (immunoglobulin-like) domain, and 128 amino acid cytoplasmic domain. It can be expressed exclusively in platelets and megakaryocytes (MKs). It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML1 Sequestered in cytoplasmic...
TMPJ-01144 TREML2 Protein, Mouse, Recombinant (His)

TREML2,TLT2,Trem-like transcript 2 protein,Triggering recept...

Mouse HEK293 Cells
TREML2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 58-62 KDa and the accession number is Q2LA85.
TMPH-01947 PPP1R15A Protein, Human, Recombinant (His)

Growth arrest and DNA damage-inducible protein GADD34,Protei...

Human E. coli
PPP1R15A Protein, Human, Recombinant (His) is expressed in E. coli.
TMPJ-01193 CLM-9 Protein, Human, Recombinant (aa 19-247, His)

TREM4,Triggering Receptor Expressed on Myeloid Cell...

Human HEK293 Cells
CMRF35-Like Molecule 9 (CD300LG) is a single-pass type I membrane protein which belongs to the CD300 family. CD300LG has one Ig-like V-type domain which mediates binding to lymphocyte. CD300LG is highly expressed in heart, skeletal muscle and placenta. CD300LG acts as a receptor which may mediate L-selectin-dependent lymphocyte rollings. CD300LG also binds SELL in a calcium dependent manner and lymphocyte. CD300LG may play a important role in molecular traffic across the capillary endothelium.
TMPH-03358 S100A9 Protein, Rat, Recombinant (His & SUMO)

Myeloid-related protein 14,S100a9,Protein S100-A9,C...

Rat E. coli
S100A9 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.0 kDa and the accession number is P50116.
TMPY-01840 TLT-1/TREML1 Protein, Human, Recombinant (His)

PRO3438,TLT-1,triggering receptor expressed on myeloid

Human HEK293 Cells
Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) do...
TMPH-03366 RUNX1 Protein, Rat, Recombinant (His & Myc)

Runt-related transcription factor 1,Core-binding factor subu...

Rat Baculovirus Insect Cells
RUNX1 Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 52.4 kDa and the accession number is Q63046.
TMPJ-00014 Resistin Protein, Human, Recombinant (His)

Resistin,C/EBP-epsilon-regulated myeloid-specific s...

Human E. coli
Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement wit...
TMPJ-00700 GADD45B Protein, Human, Recombinant (His)

MYD118,Myeloid Differentiation Primary Response Pro...

Human E. coli
Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of growth and apoptosis. GADD45B reacts to environmental stresses by mediating activation of stress-responsive MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. In addition, GADD45B participates in the down-regulation of hepatocellular carcinoma (HCC). It m...
TMPJ-01470 SCF Protein, Human, Recombinant

Mast Cell Growth Factor,c-Kit ligand,KITLG,MGF,Stem Cell Fac...

Human E. coli
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors.
TMPJ-00042 TSLP Protein, Human, Recombinant

TSLP,Thymic stromal lymphopoietin

Human E. coli
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing . lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral...
TMPJ-00994 LTBR Protein, Mouse, Recombinant (hFc)

Tnfcr,Lymphotoxin-beta receptor,Tumor necrosis factor recept...

Mouse HEK293 Cells
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs...
TMPY-04396 C-ABL/ABL1 Protein, Human, Recombinant (GST)

v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k...

Human Baculovirus Insect Cells
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an...
TMPK-00620 TLT-1/TREML1 Protein, Mouse, Recombinant (hFc)

UNQ1825/PRO3438,TLT1,Trem-like transcript 1,MGC119173,TLT-1,...

Mouse HEK293 Cells
Triggering receptor expressed on myeloid cells (TREM)-like transcript-1 (TLT-1) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-baring TREM family protein. Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) is a membrane protein receptor found in alpha-granules of platelets and megakaryocytes.
TMPK-01097 AFP Protein, Canine, Recombinant (His)

Alpha-fetoprotein,HPAFP,Alpha-1-fetoprotein,α-1-fetoprotein,...

Canine HEK293 Cells
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases. AFP Protei...
TMPK-00488 AFP Protein, Cynomolgus, Recombinant (His)

Alpha-1-fetoprotein,HPAFP,α-fetoprotein,AFPD,Alpha-fetoprote...

Cynomolgus HEK293 Cells
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases. AFP Protei...
TMPH-02740 IL-31R alpha Protein, Mouse, Recombinant (His)

ZcytoR17,Interleukin-31 receptor subunit alpha,Novel cytokin...

Mouse E. coli
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. IL-31R alpha Protein, Mouse, Recombinant (His) is expressed in E. coli expression...
TMPH-01818 CD200 Protein, Human, Recombinant (His & SUMO)

MOX1,OX-2 membrane glycoprotein,MOX2,CD200

Human E. coli
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. CD200 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.4 kDa and the accession number is P41217.
TMPJ-00189 TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)

HAVCR2,Tim-3,TIM3,T cell immunoglobulin and mucin domain3

Cynomolgus HEK293 Cells
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance...
TMPK-01357 SIRP alpha V5 Protein, Human, Recombinant (His & Avi)

MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V5,...

Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.
TMPK-01033 PSGL-1/CD162 Protein, Mouse, Recombinant (His)

CLA,SELPLG,Selpl,Selectin P ligand,PSGL1,CD162,Selp1,PSGL-1

Mouse HEK293 Cells
P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. PSGL-1/CD162 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 28.74 kDa and the accession number is Q62170.
TMPK-01267 TREM-1 Protein, Cynomolgus, Recombinant (His)

CD354,TREM-1

Cynomolgus HEK293 Cells
TREM1 (Triggering Receptor Expressed on Myeloid Cells 1) is a pro-inflammatory receptor expressed by phagocytes, which can also be released as a soluble molecule (sTREM1). The roles of TREM1 and sTREM1 in liver infection and inflammation are not clear.
TMPK-00624 CD200R1/CRTR2 Protein, Human, Recombinant (hFc)

MOX2R,CRTR2,CD200R,HCRTR2,CD200 R1,MOX2 receptor,OX2R,CD200 ...

Human HEK293 Cells
CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand. CD200R1/CRTR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53....
TMPK-00128 CD7 Protein, Human, Recombinant (His & Avi), PE-Labeled

LEU-9,TP41,CD7 molecule,Tp40,CD7,GP40

Human HEK293 Cells
CD7, also known as Leu-9, is an approximately 40 kDa glycosylated and palmitoylated transmembrane protein in the immunoglobulin superfamily.CD7 is expressed on T cells, NK cells , myeloid progenitor cells, and CD19 B progenitor cells. Among CD8 T cells, the CD7-bright population preferentially contains naïve and memory cells, while more weak expressors are primarily effector cells. CD7 Protein, Human, Recombinant (His & Avi), PE-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. ...
TMPY-04421 FES Protein, Human, Recombinant (His & GST)

FPS,FES proto-oncogene, tyrosine kinase

Human Baculovirus Insect Cells
Proto-oncogene tyrosine-protein kinase Fes/Fps, also known as Proto-oncogene c-Fes, Proto-oncogene c-Fps, Feline sarcoma oncogene, FES and FPS, is a protein which contains oneFCH domain, oneprotein kinase domain and oneSH2 domain. FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. FES is observed in the nuclear, granular and plasma membrane fractions of primary human neutrophils and the myeloid leukemia cell line, HL-6. T...
TMPJ-01237 IL-17D Protein, Human, Recombinant

IL17D,Interleukin-17D,IL-17D

Human E. coli
The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27% aa sequence ho...
TMPY-02388 SIRP beta 1 Protein, Mouse, Recombinant (His)

SIRP-beta,SIRP-β,99327N5Rik,Sirpb,Sirpb1,Sirpb1a,SIRP-β/Sirp...

Mouse HEK293 Cells
SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing 11- to 113-amino acid long, or...
TMPJ-00803 CD32B Protein, Mouse, Recombinant (His)

Fcgr2,Fcgr2b,Fc-γ-RIIB,Fc-γ RII,Low affinity immunoglobulin ...

Mouse HEK293 Cells
Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therap...
TMPK-01238 PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

PDI5,Protein-arginine deiminase type-4,HL-60,PAD4,HL-60 PAD,...

Human E. coli
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinyla...
TMPK-01364 SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated

SIRP α,MFR,SHPS1,SIRPA,BIT,SHPS-1,MYD-1,SIRP alpha,P84,CD172...

Human HEK293 Cells
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...
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重组蛋白

TREM-1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01774
Species: Human
Expression System: HEK293 Cells
TREM-2 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-01703
Species: Mouse
Expression System: HEK293 Cells
TREM-2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01148
Species: Human
Expression System: HEK293 Cells
TREM-2 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPY-00432
Species: Mouse
Expression System: HEK293 Cells
TREML2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01648
Species: Human
Expression System: HEK293 Cells
TREM-1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-06527
Species: Mouse
Expression System: HEK293 Cells
MYD88 Protein, Human, Recombinant (His)
Cat.No: TMPH-01723
Species: Human
Expression System: E. coli
TREM-1 Protein, Human, Recombinant (His & hFc)
Cat.No: TMPY-00943
Species: Human
Expression System: HEK293 Cells
PMAP-23 Protein, Pig, Recombinant (His & SUMO)
Cat.No: TMPH-03100
Species: Sus scrofa (Pig)
Expression System: E. coli
TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPY-06598
Species: Human
Expression System: HEK293 Cells
SF20 Protein, Human, Recombinant (mFc)
Cat.No: TMPY-04264
Species: Human
Expression System: HEK293 Cells
SF20 Protein, Human, Recombinant (His)
Cat.No: TMPY-00034
Species: Human
Expression System: HEK293 Cells
TREM-2 Protein, Human, Recombinant (hFc)
Cat.No: TMPY-06566
Species: Human
Expression System: HEK293 Cells
Cathelicidin-6 Protein, Bovine, Recombinant (His & SUMO)
Cat.No: TMPH-00230
Species: Bovine
Expression System: E. coli
TREM-2 Protein, Human, Recombinant (Avi & His), Biotinylated
Cat.No: TMPJ-00115
Species: Human
Expression System: HEK293 Cells
TREM-2 Protein, Human, Recombinant (mFc)
Cat.No: TMPJ-00117
Species: Human
Expression System: HEK293 Cells
KMT2E Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01526
Species: Human
Expression System: E. coli
Siglec-3/CD33 Protein, Human, Recombinant (hFc & His)
Cat.No: TMPJ-00537
Species: Human
Expression System: HEK293 Cells
TREML2 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00589
Species: Human
Expression System: HEK293 Cells
CD300LB Protein, Human, Recombinant (His)
Cat.No: TMPH-01106
Species: Human
Expression System: E. coli
TREML1 Protein, Human, Recombinant (hFc)
Cat.No: TMPJ-00193
Species: Human
Expression System: HEK293 Cells
TREML2 Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-01144
Species: Mouse
Expression System: HEK293 Cells
PPP1R15A Protein, Human, Recombinant (His)
Cat.No: TMPH-01947
Species: Human
Expression System: E. coli
CLM-9 Protein, Human, Recombinant (aa 19-247, His)
Cat.No: TMPJ-01193
Species: Human
Expression System: HEK293 Cells
S100A9 Protein, Rat, Recombinant (His & SUMO)
Cat.No: TMPH-03358
Species: Rat
Expression System: E. coli
TLT-1/TREML1 Protein, Human, Recombinant (His)
Cat.No: TMPY-01840
Species: Human
Expression System: HEK293 Cells
RUNX1 Protein, Rat, Recombinant (His & Myc)
Cat.No: TMPH-03366
Species: Rat
Expression System: Baculovirus Insect Cells
Resistin Protein, Human, Recombinant (His)
Cat.No: TMPJ-00014
Species: Human
Expression System: E. coli
GADD45B Protein, Human, Recombinant (His)
Cat.No: TMPJ-00700
Species: Human
Expression System: E. coli
SCF Protein, Human, Recombinant
Cat.No: TMPJ-01470
Species: Human
Expression System: E. coli
TSLP Protein, Human, Recombinant
Cat.No: TMPJ-00042
Species: Human
Expression System: E. coli
LTBR Protein, Mouse, Recombinant (hFc)
Cat.No: TMPJ-00994
Species: Mouse
Expression System: HEK293 Cells
C-ABL/ABL1 Protein, Human, Recombinant (GST)
Cat.No: TMPY-04396
Species: Human
Expression System: Baculovirus Insect Cells
TLT-1/TREML1 Protein, Mouse, Recombinant (hFc)
Cat.No: TMPK-00620
Species: Mouse
Expression System: HEK293 Cells
AFP Protein, Canine, Recombinant (His)
Cat.No: TMPK-01097
Species: Canine
Expression System: HEK293 Cells
AFP Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00488
Species: Cynomolgus
Expression System: HEK293 Cells
IL-31R alpha Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02740
Species: Mouse
Expression System: E. coli
CD200 Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01818
Species: Human
Expression System: E. coli
TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPJ-00189
Species: Cynomolgus
Expression System: HEK293 Cells
SIRP alpha V5 Protein, Human, Recombinant (His & Avi)
Cat.No: TMPK-01357
Species: Human
Expression System: HEK293 Cells
PSGL-1/CD162 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-01033
Species: Mouse
Expression System: HEK293 Cells
TREM-1 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01267
Species: Cynomolgus
Expression System: HEK293 Cells
CD200R1/CRTR2 Protein, Human, Recombinant (hFc)
Cat.No: TMPK-00624
Species: Human
Expression System: HEK293 Cells
CD7 Protein, Human, Recombinant (His & Avi), PE-Labeled
Cat.No: TMPK-00128
Species: Human
Expression System: HEK293 Cells
FES Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-04421
Species: Human
Expression System: Baculovirus Insect Cells
IL-17D Protein, Human, Recombinant
Cat.No: TMPJ-01237
Species: Human
Expression System: E. coli
SIRP beta 1 Protein, Mouse, Recombinant (His)
Cat.No: TMPY-02388
Species: Mouse
Expression System: HEK293 Cells
CD32B Protein, Mouse, Recombinant (His)
Cat.No: TMPJ-00803
Species: Mouse
Expression System: HEK293 Cells
PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
Cat.No: TMPK-01238
Species: Human
Expression System: E. coli
SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated
Cat.No: TMPK-01364
Species: Human
Expression System: HEK293 Cells
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Cat. No. Product Name Target Signaling Pathways
TMIJ-0330 Gilteritinib-d8

Gilteritinib-d8 是 Gilteritinib 的氘代化合物。Gilteritinib 的 CAS 号为 1254053-43-4。Gilteritinib 是一种 FLT3 抑制剂 (IC50:0.29 nM),也是一种 AXL 抑制剂 (IC50:0.73 nM),具有ATP 竞争性。

同位素标记化合物

Gilteritinib-d8
Cat.No: TMIJ-0330
Synonym:
Target:
TargetMol Loading
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