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14
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120
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Cat. No. | Product Name | ||
---|---|---|---|
L2140 | 癌细胞分化化合物库 | 406 compounds | |
406 个诱导肿瘤细胞分化化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T83738 |
SMAP 29 (ovine) TFA
Sheep Myeloid Antimicrobial Peptide 29 |
||
SMAP 29是一种抗微生物肽,同时也是绵羊防御素前体肽的C末端切割产物。在低盐和高盐条件下,对P. aeruginosa菌株PAO1具有杀菌作用,该作用在能量依赖的发光测定中表现出来(EC50s分别为0.05和0.06 µM)。它还能够以浓度依赖的方式引起绵羊红细胞的溶血。 | |||
T83706 |
BMAP 28 (bovine) TFA
Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28 |
||
BMAP 28是一种合成抗菌肽,对应牛防御素-5的132-158氨基酸。对大肠杆菌(E. coli)、金黄色葡萄球菌(S. aureus)、耐甲氧西林金黄色葡萄球菌(MRSA)、表皮葡萄球菌(S. epidermidis)及白色念珠菌(C. albicans)具有活性(MICs分别为2、2、4、1和8 µM)。在200 nM浓度下,BMAP 28能够使大肠杆菌的内膜渗透。在5 µM浓度下,减少Vero 76细胞中单纯疱疹病毒1型(HSV-1)的复制。在30 µM浓度下,对分离的人类红细胞引起溶血,并对分离的人类嗜中性粒细胞具有细胞毒性。BMAP 28 (0.8 mg/kg)可提高大肠杆菌或MRSA感染的小鼠的生存率,但对铜绿假单胞菌(P. aeruginosa)感染的小鼠无效。 | |||
T9919 |
Alemtuzumab
|
Others | Others |
Alemtuzumab 是人源化抗 CD52单克隆抗体, CD52是一种表达于大多数淋巴细胞以及少数的髓细胞类型的糖蛋白。Alemtuzumab 与能够特异性作用于 CD52 抗原,诱导淋巴细胞深度耗竭,恢复具有调节表型的 T 细胞和 B 细胞。 | |||
T12253 |
Nrf2-IN-1
|
Others; Nrf2 | Immunology/Inflammation; Others |
Nrf2-IN-1 是 Nrf2抑制剂,可用于研究急性髓性白血病药物。 | |||
T9060 |
STM2457
|
Apoptosis; Others | Apoptosis; Others |
STM2457 是一种 RNA 甲基转移酶 METTL3 的抑制剂 (IC50=16.9 nM),具有选择性和口服活性。STM2457 可用于急性髓系白血病 (AML) 的研究。 | |||
T13774 |
ML390
|
Others; Dehydrogenase | Metabolism; Others |
ML390 是二氢乳清酸脱氢酶抑制剂。他是骨髓分化的诱导剂,能够引起鼠 (ER-HoxA9) 以及人 (U937 and THP1) 急性髓细胞性白血病 (AML) 细胞发生骨髓分化。 | |||
T13950 |
UC-514321
|
Apoptosis; STAT | Apoptosis; JAK/STAT signaling; Stem Cells |
UC-514321 是NSC370284 的结构类似物,靶向STAT3/5并选择性抑制TET1的表达,且活性更高。它有较低的毒性,在体内外均表现出良好的抗急性髓系白血病活性。 | |||
T12943 |
SNDX-5613
|
Epigenetic Reader Domain; Histone Methyltransferase | Chromatin/Epigenetic |
SNDX-5613 是一种 Menin-MLL 特异性抑制剂,Ki 为 0.149 nM,IC50 为 10 在 20 nM 之间,可用于 MLL 基因重排的急性白血病研究。 | |||
T83698 |
Cathelicidin-2 (128-153) (chicken) TFA
Fowlicidin-2 (128-153),CATH-2 (128-153),Myeloid Antimicrobial Peptide 27 (128-153) |
||
Cathelicidin-2 (CATH-2) (128-153) 是一种合成抗菌肽,对应于鸡CATH-2的128至153个氨基酸。该化合物对E. coli、S. aureus、S. enteritidis和B. globigii展示出浓度依赖性的活性。CATH-2 (128-153) (40 µM) 可诱导孤立的鸡红细胞溶解,但对孤立的人外周血单个核细胞(PBMCs)无细胞毒性。它能促进化学因子(C-C-基序)配体2 (CCL2)的产生,并抑制LPS诱导的TNF-α、IL-6、IL-8和IL-10在孤立的人PBMCs中的产生。 | |||
T9041 |
AES-350
|
Apoptosis; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair |
AES-350 是一种具有口服活性HDAC6抑制剂,IC50和Ki 分别为 0.0244 μM 和 0.035 μM。它对 HDAC3、8 和 11 的 IC50值分别为 0.187、0.245和大于1μM。它通过抑制 HDAC 诱导 AML 细胞凋亡,可研究急性髓系白血病。 | |||
T7138 |
FB23-2
|
Apoptosis; Others | Apoptosis; Others |
FB23-2 是一种 mRNA N6- 甲基腺嘌呤脱甲基酶 FTO 选择性抑制剂,IC50值为 2.6 μM。它具有抗增殖作用,可研究急性髓系白血病。 | |||
T8882 |
Vodobatinib
K-0706 |
Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Vodobatinib (K-0706) 是第三代具有口服活性的Bcr-Abl1酪氨酸激酶抑制剂,IC50=7 nM,对大多数 BCR-ABL1 点突变体具有活性,但对 BCR-ABL1T315I 无活性。它可用于研究慢性粒细胞白血病 (CML)。 | |||
T64338 |
AKI603
AKI 603,AKI-603 |
Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic |
AKI603 是一种极光激酶 A 抑制剂,IC50值为 12.3 nM。它对白血病细胞具有很强的抗增殖活性,可用于克服白血病中 BCR-ABL-T315I 耐药性突变。 | |||
T9765 |
TJ-M2010-5
|
MyD88 | Immunology/Inflammation |
TJ-M2010-5 是一种 MyD88 抑制剂,可与 TIR 结构域结合以干扰其同源二聚化并抑制 MyD88 信号传导。 TJ-M2010-5 可用于心肌缺血/再灌注损伤研究。 | |||
T24269 |
KPT-251
KPT251 |
Others | Others |
KPT-251 是一种选择性核输出抑制剂。 | |||
T11344 |
G150
|
DNA; cGAS | DNA Damage/DNA Repair; Immunology/Inflammation |
G150 是高选择性h-cGAS 抑制剂,IC50值为 10.2 nM,用于抑制 dsDNA 引发的干扰素表达。 | |||
T8497 |
SX-682
|
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
SX-682 是口服有效的 CXCR1和 CXCR2变构抑制剂,可以阻断肿瘤髓系抑制细胞募集并增强 T 细胞活化和抗肿瘤免疫,具有治疗去势抵抗性前列腺癌的潜力。 | |||
T9014 |
SKI-178
|
Apoptosis; S1P Receptor | Apoptosis; GPCR/G Protein |
SKI-178 是一种鞘氨醇激酶-1(SphK1)和 SphK2抑制剂,以 CDK1 依赖性方式诱导人急性髓性白血病细胞凋亡。 | |||
T16557 |
PNU-159682
|
Topoisomerase; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; DNA Damage/DNA Repair |
PNU-159682 是蒽环类新霉素的代谢产物,是一种 DNA 拓扑异构酶 II 抑制剂,具有出色的细胞毒性。 | |||
T10606 |
BRD0705
|
GSK-3 | PI3K/Akt/mTOR signaling; Stem Cells |
BRD0705 是一种具有旁系选择性的、口服具有活性的GSK3α抑制剂,其 IC50=66 nM,Kd=4.8 μM。 它与 GSK3β (其 IC50=515 nM) 相比,对GSK3α的选择性更高 (8 倍)。它可用于研究急性髓细胞性白血病。 | |||
T14919 |
CDKI-73
|
Apoptosis; CDK | Apoptosis; Cell Cycle/Checkpoint |
CDKI-73 是一种具有口服活性的 CDK9抑制剂,其对 CDK9、CDK1 和 CDK2 的Ki 值分别为 4 nM、4 nM 和 3 nM。CDKI-73 可下调 RNA 聚合酶 II 的磷酸化。CDKI-73 也是一种 Rab11 的抑制剂。 | |||
T9705 |
TL-895
|
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
TL-895 是口服有效的,ATP 竞争性的,以及高度选择性和不可逆的BTK 抑制剂,IC50和Ki 分别为 1.5 nM 和 11.9 nM。TL-895在 JAKi 复发/难治性骨髓纤维化、急性髓系白血病、COVID-19 和癌症方面有研究的价值。 | |||
T38562 |
AKN-028
|
FLT | Angiogenesis; Tyrosine Kinase/Adaptors |
AKN-028 是酪氨酸激酶 FLT3的抑制剂,可剂量依赖性的诱导 FLT3的自磷酸化。 | |||
T2620 |
G-749
G749 |
Apoptosis; FLT; c-RET; TAM Receptor; Aurora Kinase | Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Tyrosine Kinase/Adaptors |
G-749 是一种新型 FLT3 抑制剂,对 FLT3 野生型和突变体有持续的抑制作用,IC50值分别为 0.4 nM 和 0.6 nM。它可用于急性髓系白血病的耐药研究。 | |||
T22553 |
Adaphostin
1-Adamantyl 4-((2,5-Dihydroxybenzyl)Amino)Benzoate,NSC 680410 |
Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Adaphostin (NSC-680410) 是 AG957 金刚烷酯,是一种 p210bcr/abl 抑制剂,可诱导 T 淋巴细胞白血病细胞系凋亡。它增加了 CLL B 细胞内活性氧的水平,对慢性和急性髓系白血病细胞具有显著的选择性活性。 | |||
T8978 |
DD1
3,3'-Diamino-4'-methoxyflavone,HUN85111 |
Proteasome | Proteases/Proteasome; Ubiquitination |
DD1 (HUN85111) 是一种蛋白酶体抑制剂,可诱导人髓系肿瘤选择性凋亡。 | |||
T28475 |
Pyrazoloacridine
PD-115934,NSC 366140,NSC-366140,PD 115,934,PD 115934 |
Apoptosis; Topoisomerase | Apoptosis; DNA Damage/DNA Repair |
Pyrazoloacridine (PD 115934) 是一种核酸结合剂,在 K562 细胞中抑制 topo I 和 II 的活性,IC50 为 1.25 μM。 Pyrazoloacridine 具有抗癌活性。 | |||
T10384 |
Farudodstat
ASLAN003 |
Apoptosis; Dehydrogenase; DNA/RNA Synthesis | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Farudodstat (ASLAN003) 是一种具有口服活性的二氢乳清酸脱氢酶 (DHODH) 抑制剂,对人 DHODH 酶的IC50为 35 nM。它通过激活 AP-1 转录因子来抑制蛋白质合成,可以诱导凋亡,并在急性髓样白血病异种移植小鼠中大大延长其生存期。 | |||
T1979 |
AVN-944
VX-944 |
Dehydrogenase | Metabolism |
AVN-944 (VX-944) 是一种选择性的、非竞争性 IMPDH 抑制剂,对IMPDH1和IMPDH2的Ki=为6-10nM。 | |||
T16028 |
IMB-XH1
Mcl1-IN-2,7-[(2-吡啶基氨基)-2-噻吩基甲基]-8-喹啉醇 |
BCL; Antibacterial | Apoptosis; Microbiology/Virology |
IMB-XH1 (Mcl1-IN-2) 是一种骨髓细胞因子 1 抑制剂。它也是非竞争性的 Delhi metallo-β-lactamase(NDM-1) 抑制剂。它对金属 β-内酰胺酶 NDM-1,IMP-4,ImiS 和 L1 的 IC50值分别为 0.4637 μM,3.980 μM,0.2287 μM 和 1.158 μM。 | |||
T3184 |
Kevetrin hydrochloride
Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride |
Mdm2; p53 | Apoptosis |
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) 是一种小分子,是肿瘤抑制蛋白 p53 的激活剂,具有潜在的抗肿瘤活性。 | |||
T2066 |
Quizartinib
AC220,奎扎替尼 |
Apoptosis; FLT; Autophagy; Ligands for Target Protein for PROTAC | Angiogenesis; Apoptosis; Autophagy; PROTAC; Tyrosine Kinase/Adaptors |
Quizartinib (AC220) 是一种第二代 Ⅱ 型 FLT3 酪氨酸激酶抑制剂,具有口服活性和高选择性,抑制 FLT3-WT 和 FLT3-ITD 自磷酸化 (IC50=4.1/1.1 nM)。Quizartinib 可以诱导肿瘤细胞凋亡。 | |||
T0942 |
Quinacrine dihydrochloride
疟疾平,Mepacrine dihydrochloride,阿的平,SN-390,Quinacrine 2HCl |
Apoptosis; Mitophagy; DNA; Phospholipase; Parasite; Autophagy; Histamine Receptor | Apoptosis; Autophagy; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience |
Quinacrine dihydrochloride (Mepacrine dihydrochloride) 是一种具有口服活性的抗疟剂,抑制 NF-κB 并激活 p53 信号转导,诱导肿瘤细胞发生凋亡,具有抗肿瘤和抗寄生虫活性。 | |||
T2346L |
Enasidenib mesylate
AG221 mesylate,AG 221 mesylate,恩西地平甲磺酸盐,AG-221 mesylate |
Dehydrogenase | Metabolism |
Enasidenib mesylate (AG-221 mesylate) 是一种具有有效性和选择性的 IDH2 突变酶抑制剂,可促进白血病成髓细胞的分化,可用于治疗急性髓系白血病。 | |||
T25006 |
AGI-14100
AGI 14100 |
Dehydrogenase | Metabolism |
AGI-14100 是一种新型且可口服的 mIDH1 抑制剂。AGI-14100 用于治疗原发性人类髓性白血病。 | |||
T12629L |
MIK665
S-64315 |
BCL | Apoptosis |
MIK665 (S-64315) (S-64315) 对髓系细胞白血病具有抑制作用。 | |||
T27299 |
F-14512
F14512 |
Topoisomerase | DNA Damage/DNA Repair |
F-14512 (free base) 是一种拓扑异构酶II抑制剂,可用于研究急性髓性白血病。 | |||
T12041 |
MIM1
Inhibitor of Mcl-1 |
BCL | Apoptosis |
MIM1 (Inhibitor of Mcl-1) 是一种骨髓细胞因子 1 抑制剂。 | |||
T4231 |
MD2-IN-1
|
TLR | Immunology/Inflammation |
MD2-IN-1 是骨髓分化蛋白 2 (MD2) 的抑制剂,对重组人 MD2 (rhMD2) 的 KD 为 189 μM。 | |||
TQ0245 |
Sapacitabine
CS682,CYC682 |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Sapacitabine (CS682) 是一种可口服的核苷类似物前体化合物,具有潜在的抗肿瘤活性,可用于研究急性髓系白血病。 | |||
T31088 |
CPX-351
CPX 351,Vyxeos,CPX351 |
Others | Others |
CPX-351 (Vyxeos) 是阿糖胞苷和柔红霉素的脂质体封装物,具有潜在的抗肿瘤活性,可用与研究急性髓系白血病。 | |||
T14501 |
BAY-2402234
|
Dehydrogenase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
BAY-2402234 是一种选择性二氢乳清酸脱氢酶的抑制剂,可研究骨髓恶性肿瘤。 | |||
T3099 |
Pinometostat
EPZ-5676 |
Histone Methyltransferase | Chromatin/Epigenetic |
Pinometostat (EPZ-5676) 是有效的DOT1L 组蛋白甲基转移酶抑制剂,Ki 为 80 pM。它可用于研究多种白血病治疗的实验。 | |||
T6857 |
HLCL-61 hydrochloride
HLCL61,HLCL-61 HCL |
Apoptosis; Histone Methyltransferase | Apoptosis; Chromatin/Epigenetic |
HLCL-61 hydrochloride (HLCL-61 HCL) 是小分子蛋白精氨酸甲基转移酶 5 抑制剂。 | |||
T9749 |
FHD-286
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
FHD-286 是 BRM/BRG1 ATPase 的抑制剂,可用于治疗 BAF 相关疾病如急性髓性白血病的研究。 | |||
T62750 |
TREM2 agonist-2
|
Others | Others |
TREM2 agonist-2 (I-192) 是一种具有口服活性和高效性的髓系细胞触发受体 2 (TREM2) 激动剂 ,可用于研究神经退行性疾病。 | |||
T83966 |
LSD1-IN-30
|
Histone Demethylase | Chromatin/Epigenetic |
LSD1-IN-30 是赖氨酸特异性脱甲基酶 1 (LSD1) 抑制剂,具有抗癌活性,可用于研究小细胞肺癌和急性髓细胞白血病。 | |||
T27488 |
GSK-690
GSK 690,GSK690 |
Histone Demethylase | Chromatin/Epigenetic |
GSK-690 是一种具有选择性和高效性的赖氨酸去甲基化酶1 (LSD 1) 抑制剂,可诱导急性髓系白血病 (AML) 中白血病干细胞的分化,可用于研究白血病。 | |||
T7776 |
ADH-503
GB1275 |
Complement System | Immunology/Inflammation |
ADH-503 (GB1275) 是一种可口服的变构CD11b 激动剂,可以导致与肿瘤相关的巨噬细胞重新极化,可减轻骨髓细胞的免疫抑制,并增强树突状细胞的反应。 | |||
T8871 |
C/EBPα inducer 1
4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl- |
Others | Others |
C/EBPα inducer 1 (4(3H)-Quinazolinone, 6-fluoro-2-[(1E)-2-(5-nitro-2-furanyl)ethenyl]-3-phenyl-) 是一种C/EBPα和骨髓细胞分化的诱导剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S1435 |
Notopterol
|
Apoptosis; Others | Apoptosis; Others |
Notopterol 是从羌活提取的一种香豆素,可诱导细胞凋亡,具有解热、缓解疼痛和抗炎作用。它有用于急性髓细胞性白血病的潜力。 | |||
T1882 |
Meisoindigo
N-Methylisoindigotin,Methylisoindigotin,Natura-α,甲异靛,Dian III,异甲靛 |
Apoptosis | Apoptosis |
Meisoindigo (Natura-α) 是 Indirubin 的衍生物,可以造成急性髓细胞性白血病细胞周期在 G0/G1 期停滞,并诱导凋亡,具有高抗肿瘤活性。 | |||
T34398 |
Rotundifuran
|
Others | Others |
Rotundifuran 是从 Vitex rotundifolia 的果实中提取的。 Rotundifuran 抑制细胞周期进程并诱导人髓性白血病细胞凋亡。 | |||
T11060 |
DMAPT
Dimethylamino Parthenolide |
NF-κB | NF-κB |
DMAPT (Dimethylamino Parthenolide) 是一种具有口服活性的NF-κB 抑制剂,是一种 Parthenolide (PTL) 的类似物,对原发性急性髓性白血病细胞的LD50值为1.7 μM。具有潜在的抗肿瘤和抗转移作用。 | |||
TN1369 |
Alloimperatorin
Prangenidin,别欧前胡素 |
Others | Others |
Alloimperatorin (Prangenidin) 是一种从Angelica dahurica 的提取得到的香豆素类化合物,具有抗肿瘤作用。 | |||
T4036 |
Solasodine
Solancarpidine,Purapuridine,澳洲茄铵,Solasodin |
Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal | Apoptosis; Microbiology/Virology; Others; Ubiquitination |
Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。 | |||
TN1215 |
(2S)-2'-Methoxykurarinone
2'-甲氧基苦参黄素,2'-Methoxykurarinone,2'-O-Methylkurarinone |
Akt; Antifection | Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling |
(2S)-2'-Methoxykurarinone 是一种分离自苦参根中的化合物,具有抗炎、解热、抗糖尿病和抗肿瘤活性。它对人髓系白血病 HL-60 细胞具有细胞毒活性。它能够下调 RANKL 信号,抑制破骨细胞形成和骨吸收。 | |||
T3733 |
(E)-Methyl 4-coumarate
Methyl trans-p-Coumarat,OMpCA,反式对羟基肉桂酸,Methyl 4-hydroxycinnamate |
Apoptosis; Others; Antibacterial | Apoptosis; Microbiology/Virology; Others |
Methyl (E)-4-hydroxycinnamatee在几种植物中发现,如洋葱或海巴戟叶中。它与 Carnosic Acid 联用可诱导细胞凋亡,杀死急性髓性白血病细胞。它具有抗氧化和抗菌活性。 | |||
T4S1943 |
Kirenol
奇壬醇,奇任醇,Kirel |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的,具有抗氧化、抗炎、抗过敏、抗关节炎活性,可用于缓解疼痛的研究。 | |||
TN2211 |
Silybin B
Silibinin B |
Apoptosis; Beta Amyloid; Bcr-Abl | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Neuroscience; Tyrosine Kinase/Adaptors |
Silybin B (Silibinin B) 是雷洛昔芬4′-和6-葡萄糖醛酸化的有效抑制剂,是水飞蓟素有效的抗纤维原性和抗低聚物成分,具有清除1,1-二苯基-2-吡啶酰肼(DPPH)自由基的活性 ,可通过减轻 DNA 损伤和细胞凋亡对顺铂诱导的神经毒性具有保护作用。Silybin B 对人慢性髓系白血病 K562细胞的生长抑制和诱导凋亡有较强的作用。 | |||
TN5585 |
14-Deoxy-11-hydroxyandrographolide
|
||
14-Deoxy-11-hydroxyandrographolide shows potent cell differentiation-inducing activity towards mouse myeloid leukemia (M1) cells. | |||
T80259 |
PMAP-23
|
Others | Others |
PMAP-23为具有生物活性的抗菌肽(AMP),源自猪骨髓。 | |||
TN5593 |
Euphohelioscopin A
|
||
Euphohelioscopin A, an activator of protein kinase C (PKC), it inhibits proliferation and induces differentiation of the myeloid leukemia cell lines THP-1 and HL-60. Euphohelioscopin A has anti-inflammary activity, it exhibits moderate inhibitory activity | |||
T36417 |
Nargenicin
Antibiotic 47444 |
Others | Others |
Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01774 |
TREM-1 Protein, Human, Recombinant (His)
TREM-1,triggering receptor expressed on myeloid cel... |
Human | HEK293 Cells |
TREM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.8 kDa and the accession number is Q38L15. | |||
TMPY-01703 |
TREM-2 Protein, Mouse, Recombinant (His)
Trem2b,TREM-2,Trem2c,triggering receptor expressed on my... |
Mouse | HEK293 Cells |
TREM-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is Q99NH8-1. | |||
TMPY-01148 |
TREM-2 Protein, Human, Recombinant (His)
TREM-2,Trem2b,triggering receptor expressed on myeloid |
Human | HEK293 Cells |
TREM-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.9 kDa and the accession number is Q5TCX1. | |||
TMPY-00432 |
TREM-2 Protein, Mouse, Recombinant (hFc)
triggering receptor expressed on myeloid cells 2,Tr... |
Mouse | HEK293 Cells |
TREM-2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.4 kDa and the accession number is Q99NH8-1. | |||
TMPY-01648 |
TREML2 Protein, Human, Recombinant (His)
TLT2,dJ238O23.1,triggering receptor expressed on myeloid... |
Human | HEK293 Cells |
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune respons... | |||
TMPY-06527 |
TREM-1 Protein, Mouse, Recombinant (His)
triggering receptor expressed on myeloid cells 1 |
Mouse | HEK293 Cells |
TREM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.57 kDa and the accession number is Q9JKE2-1. | |||
TMPH-01723 |
MYD88 Protein, Human, Recombinant (His)
Myeloid differentiation primary response protein My... |
Human | E. coli |
MYD88 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.2 kDa and the accession number is Q99836. | |||
TMPY-00943 |
TREM-1 Protein, Human, Recombinant (His & hFc)
TREM-1,triggering receptor expressed on myeloid cel... |
Human | HEK293 Cells |
TREM-1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 48.3 kDa and the accession number is Q38L15. | |||
TMPH-03100 |
PMAP-23 Protein, Pig, Recombinant (His & SUMO)
PMAP23,Antibacterial peptide PMAP-23,Myeloid antiba... |
Sus scrofa (Pig) | E. coli |
Exerts antimicrobial activity against both Gram-positive and negative bacteria at concentrations of 2-16 micro molar. Its activity appears to be mediated by its ability to damage bacterial membranes. PMAP-23 Protein, Pig, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 19.0 kDa and the accession number is P49930. | |||
TMPY-06598 |
TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated
TREM-2,Trem2a,Trem2c,triggering receptor expressed on my... |
Human | HEK293 Cells |
TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 20.69 kDa and the accession number is NP_061838.1. | |||
TMPY-04264 |
SF20 Protein, Human, Recombinant (mFc)
IL27,EUROIMAGE1875335,myeloid-derived growth factor... |
Human | HEK293 Cells |
SF20 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42.2 kDa and the accession number is Q969H8. | |||
TMPY-00034 |
SF20 Protein, Human, Recombinant (His)
myeloid-derived growth factor,R33729_1,IL25,IL27w,S... |
Human | HEK293 Cells |
SF20 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.3 kDa and the accession number is Q969H8. | |||
TMPY-06566 |
TREM-2 Protein, Human, Recombinant (hFc)
Trem2b,TREM-2,Trem2a,Trem2c,triggering receptor expressed on... |
Human | HEK293 Cells |
TREM-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.16 kDa and the accession number is NP_061838.1. | |||
TMPH-00230 |
Cathelicidin-6 Protein, Bovine, Recombinant (His & SUMO)
CATHL6,Antibacterial peptide BMAP-27,Myeloid antiba... |
Bovine | E. coli |
Exerts a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, and fungi. Cathelicidin-6 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 16.2 kDa and the accession number is P54228. | |||
TMPJ-00115 |
TREM-2 Protein, Human, Recombinant (Avi & His), Biotinylated
Triggering receptor expressed on monocytes 2,Triggering rece... |
Human | HEK293 Cells |
TREM-2 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is Q9NZC2. | |||
TMPJ-00117 |
TREM-2 Protein, Human, Recombinant (mFc)
Triggering receptor expressed on myeloid cells 2,Tr... |
Human | HEK293 Cells |
TREM-2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 50-65 KDa and the accession number is Q9NZC2. | |||
TMPH-01526 |
KMT2E Protein, Human, Recombinant (His & Myc)
Inactive histone-lysine N-methyltransferase 2E,Myeloid |
Human | E. coli |
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle r... | |||
TMPJ-00537 |
Siglec-3/CD33 Protein, Human, Recombinant (hFc & His)
Myeloid Cell Surface Antigen CD33,CD33,Siglec-3,SIG... |
Human | HEK293 Cells |
CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are c... | |||
TMPJ-00589 |
TREML2 Protein, Human, Recombinant (hFc)
C6orf76,TLT2,Triggering receptor expressed on myeloid |
Human | HEK293 Cells |
TREML2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 80-110 KDa and the accession number is AAI25079.1. | |||
TMPH-01106 |
CD300LB Protein, Human, Recombinant (His)
CMRF35-like molecule 7,CD300LB,CMRF35A2,CD300b,TREM-5,Leukoc... |
Human | E. coli |
Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. CD300LB Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 18.8 kDa and the accession number is A8K4G0. | |||
TMPJ-00193 |
TREML1 Protein, Human, Recombinant (hFc)
TLT-1,Trem-Like Transcript 1 Protein,TLT1,Triggering Recepto... |
Human | HEK293 Cells |
Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-like V-type (immunoglobulin-like) domain, and 128 amino acid cytoplasmic domain. It can be expressed exclusively in platelets and megakaryocytes (MKs). It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML1 Sequestered in cytoplasmic... | |||
TMPJ-01144 |
TREML2 Protein, Mouse, Recombinant (His)
TREML2,TLT2,Trem-like transcript 2 protein,Triggering recept... |
Mouse | HEK293 Cells |
TREML2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 58-62 KDa and the accession number is Q2LA85. | |||
TMPH-01947 |
PPP1R15A Protein, Human, Recombinant (His)
Growth arrest and DNA damage-inducible protein GADD34,Protei... |
Human | E. coli |
PPP1R15A Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPJ-01193 |
CLM-9 Protein, Human, Recombinant (aa 19-247, His)
TREM4,Triggering Receptor Expressed on Myeloid Cell... |
Human | HEK293 Cells |
CMRF35-Like Molecule 9 (CD300LG) is a single-pass type I membrane protein which belongs to the CD300 family. CD300LG has one Ig-like V-type domain which mediates binding to lymphocyte. CD300LG is highly expressed in heart, skeletal muscle and placenta. CD300LG acts as a receptor which may mediate L-selectin-dependent lymphocyte rollings. CD300LG also binds SELL in a calcium dependent manner and lymphocyte. CD300LG may play a important role in molecular traffic across the capillary endothelium. | |||
TMPH-03358 |
S100A9 Protein, Rat, Recombinant (His & SUMO)
Myeloid-related protein 14,S100a9,Protein S100-A9,C... |
Rat | E. coli |
S100A9 Protein, Rat, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 29.0 kDa and the accession number is P50116. | |||
TMPY-01840 |
TLT-1/TREML1 Protein, Human, Recombinant (His)
PRO3438,TLT-1,triggering receptor expressed on myeloid |
Human | HEK293 Cells |
Trem-like transcript 1 protein, also known as Triggering receptor expressed on myeloid cells-like protein 1, TREML1 and TLT-1, is a cytoplasm and single-pass type I membrane protein. TREML1 / TLT-1 is expressed exclusively in platelets and megakaryocytes (MKs) and that its expression is up-regulated dramatically upon platelet activation. It is a receptor that may play a role in the innate and adaptive immune response. TREML1 / TLT-1 contains the characteristic single V-set immunoglobulin (Ig) do... | |||
TMPH-03366 |
RUNX1 Protein, Rat, Recombinant (His & Myc)
Runt-related transcription factor 1,Core-binding factor subu... |
Rat | Baculovirus Insect Cells |
RUNX1 Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 52.4 kDa and the accession number is Q63046. | |||
TMPJ-00014 |
Resistin Protein, Human, Recombinant (His)
Resistin,C/EBP-epsilon-regulated myeloid-specific s... |
Human | E. coli |
Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement wit... | |||
TMPJ-00700 |
GADD45B Protein, Human, Recombinant (His)
MYD118,Myeloid Differentiation Primary Response Pro... |
Human | E. coli |
Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of growth and apoptosis. GADD45B reacts to environmental stresses by mediating activation of stress-responsive MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. In addition, GADD45B participates in the down-regulation of hepatocellular carcinoma (HCC). It m... | |||
TMPJ-01470 |
SCF Protein, Human, Recombinant
Mast Cell Growth Factor,c-Kit ligand,KITLG,MGF,Stem Cell Fac... |
Human | E. coli |
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors. | |||
TMPJ-00042 |
TSLP Protein, Human, Recombinant
TSLP,Thymic stromal lymphopoietin |
Human | E. coli |
Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP and sfTSLP produced by alternative splicing . lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral... | |||
TMPJ-00994 |
LTBR Protein, Mouse, Recombinant (hFc)
Tnfcr,Lymphotoxin-beta receptor,Tumor necrosis factor recept... |
Mouse | HEK293 Cells |
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs... | |||
TMPY-04396 |
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k... |
Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... | |||
TMPK-00620 |
TLT-1/TREML1 Protein, Mouse, Recombinant (hFc)
UNQ1825/PRO3438,TLT1,Trem-like transcript 1,MGC119173,TLT-1,... |
Mouse | HEK293 Cells |
Triggering receptor expressed on myeloid cells (TREM)-like transcript-1 (TLT-1) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-baring TREM family protein. Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) is a membrane protein receptor found in alpha-granules of platelets and megakaryocytes. | |||
TMPK-01097 |
AFP Protein, Canine, Recombinant (His)
Alpha-fetoprotein,HPAFP,Alpha-1-fetoprotein,α-1-fetoprotein,... |
Canine | HEK293 Cells |
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases. AFP Protei... | |||
TMPK-00488 |
AFP Protein, Cynomolgus, Recombinant (His)
Alpha-1-fetoprotein,HPAFP,α-fetoprotein,AFPD,Alpha-fetoprote... |
Cynomolgus | HEK293 Cells |
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases. AFP Protei... | |||
TMPH-02740 |
IL-31R alpha Protein, Mouse, Recombinant (His)
ZcytoR17,Interleukin-31 receptor subunit alpha,Novel cytokin... |
Mouse | E. coli |
Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro. IL-31R alpha Protein, Mouse, Recombinant (His) is expressed in E. coli expression... | |||
TMPH-01818 |
CD200 Protein, Human, Recombinant (His & SUMO)
MOX1,OX-2 membrane glycoprotein,MOX2,CD200 |
Human | E. coli |
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues. CD200 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.4 kDa and the accession number is P41217. | |||
TMPJ-00189 |
TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (His)
HAVCR2,Tim-3,TIM3,T cell immunoglobulin and mucin domain3 |
Cynomolgus | HEK293 Cells |
T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance... | |||
TMPK-01357 |
SIRP alpha V5 Protein, Human, Recombinant (His & Avi)
MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V5,... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal. | |||
TMPK-01033 |
PSGL-1/CD162 Protein, Mouse, Recombinant (His)
CLA,SELPLG,Selpl,Selectin P ligand,PSGL1,CD162,Selp1,PSGL-1 |
Mouse | HEK293 Cells |
P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. PSGL-1/CD162 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 28.74 kDa and the accession number is Q62170. | |||
TMPK-01267 |
TREM-1 Protein, Cynomolgus, Recombinant (His)
CD354,TREM-1 |
Cynomolgus | HEK293 Cells |
TREM1 (Triggering Receptor Expressed on Myeloid Cells 1) is a pro-inflammatory receptor expressed by phagocytes, which can also be released as a soluble molecule (sTREM1). The roles of TREM1 and sTREM1 in liver infection and inflammation are not clear. | |||
TMPK-00624 |
CD200R1/CRTR2 Protein, Human, Recombinant (hFc)
MOX2R,CRTR2,CD200R,HCRTR2,CD200 R1,MOX2 receptor,OX2R,CD200 ... |
Human | HEK293 Cells |
CD200Fc, a chimeric molecule including the extracellular domain of CD200 and a murine IgG2a Fc region, regulates immune responses following engagement of a cell surface receptor, CD200R, expressed on cells of the myeloid and T cell lineage. A recent report focused attention on a family of CD200Rs, but concluded that only one member used CD200 as its ligand. CD200R1/CRTR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.... | |||
TMPK-00128 |
CD7 Protein, Human, Recombinant (His & Avi), PE-Labeled
LEU-9,TP41,CD7 molecule,Tp40,CD7,GP40 |
Human | HEK293 Cells |
CD7, also known as Leu-9, is an approximately 40 kDa glycosylated and palmitoylated transmembrane protein in the immunoglobulin superfamily.CD7 is expressed on T cells, NK cells , myeloid progenitor cells, and CD19 B progenitor cells. Among CD8 T cells, the CD7-bright population preferentially contains naïve and memory cells, while more weak expressors are primarily effector cells. CD7 Protein, Human, Recombinant (His & Avi), PE-Labeled is expressed in HEK293 mammalian cells with C-His-Avi tag. ... | |||
TMPY-04421 |
FES Protein, Human, Recombinant (His & GST)
FPS,FES proto-oncogene, tyrosine kinase |
Human | Baculovirus Insect Cells |
Proto-oncogene tyrosine-protein kinase Fes/Fps, also known as Proto-oncogene c-Fes, Proto-oncogene c-Fps, Feline sarcoma oncogene, FES and FPS, is a protein which contains oneFCH domain, oneprotein kinase domain and oneSH2 domain. FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. FES is observed in the nuclear, granular and plasma membrane fractions of primary human neutrophils and the myeloid leukemia cell line, HL-6. T... | |||
TMPJ-01237 |
IL-17D Protein, Human, Recombinant
IL17D,Interleukin-17D,IL-17D |
Human | E. coli |
The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27% aa sequence ho... | |||
TMPY-02388 |
SIRP beta 1 Protein, Mouse, Recombinant (His)
SIRP-beta,SIRP-β,99327N5Rik,Sirpb,Sirpb1,Sirpb1a,SIRP-β/Sirp... |
Mouse | HEK293 Cells |
SIRPB1A (Signal-regulatory protein beta 1A), also known as SIRP beta 1, belongs to signal-regulatory-protein (SIRP) family, and immunoglobulin superfamily. Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on myeloid and neural cells that have been shown to recruit SH2 domain-containing protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine kinase-coupled signaling. SIRP are classified as SIRP alpha molecules, containing 11- to 113-amino acid long, or... | |||
TMPJ-00803 |
CD32B Protein, Mouse, Recombinant (His)
Fcgr2,Fcgr2b,Fc-γ-RIIB,Fc-γ RII,Low affinity immunoglobulin ... |
Mouse | HEK293 Cells |
Low affinity immunoglobulin gamma Fc region receptor II (CD32B) is a single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains. The inhibitory CD32B is expressed on B cells and myeloid dendritic cells. Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target formonoclonal antibody therap... | |||
TMPK-01238 |
PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
PDI5,Protein-arginine deiminase type-4,HL-60,PAD4,HL-60 PAD,... |
Human | E. coli |
Peptidylarginine deiminase type4 (PADI4) was firstly identified as a non-MHC RA genetic risk factor. Furthermore, PADI4 risk allele possessed the association with bone damage regardless of anti citrullinated peptide antibody (ACPA) positivity in Asian RA patients. PADI4 gene codes PAD4 protein which has post-translational modification activity (citrullination). Padi4 is mainly expressed in myeloid cells and granulocytes. PADI4 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinyla... | |||
TMPK-01364 |
SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated
SIRP α,MFR,SHPS1,SIRPA,BIT,SHPS-1,MYD-1,SIRP alpha,P84,CD172... |
Human | HEK293 Cells |
Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V6 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0330 |
Gilteritinib-d8
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Gilteritinib-d8 是 Gilteritinib 的氘代化合物。Gilteritinib 的 CAS 号为 1254053-43-4。Gilteritinib 是一种 FLT3 抑制剂 (IC50:0.29 nM),也是一种 AXL 抑制剂 (IC50:0.73 nM),具有ATP 竞争性。 |