219
46
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12
11
Cat. No. | Product Name | ||
---|---|---|---|
L2191 | 抗乳腺癌化合物库 | 1939 compounds | |
1939 种与乳腺癌相关的化合物,可以用于抗乳腺癌药物研发和药理研究; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15249 |
Estrogen receptor modulator 1
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
Estrogen receptor modulator 1 是一种有效的、具有口服活性的、选择性雌激素受体(estrogen receptor)调节剂 (SERM),其 pIC50为 0.46。它能够诱导 Tamoxifen 耐药、激素非依赖性异种移植瘤的消退。 | |||
T78646 |
Estrogen receptor antagonist 8
|
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Estrogen receptor antagonist 8 作为一种雌激素受体(ER)拮抗剂,具有抗子宫活性和潜在的抗肿瘤活性,可用于研究卵巢功能障碍。 | |||
T40893 |
Estrogen receptor modulator 6
|
Others | Others |
Estrogen receptor modulator 6 (compound 3a) is a highly specific and potent agonist of the estrogen receptor (ER) β with a remarkable affinity (K i = 0.44 nM). This compound exhibits an impressive 19-fold selectivity for ERβ over ERα, as evidenced by its affinity (K i = 8.4 nM). | |||
T11236 |
Giredestrant tartrate
Estrogen receptor antagonist 1 |
Estrogen Receptor/ERR; Others | Endocrinology/Hormones; Others |
Giredestrant tartrate (Estrogen receptor antagonist 1) 是一种新型的、具有口服活性的、有选择性的、有效的的非甾体雌激素受体拮抗剂。Giredestrant tartrate 与 ER 强效结合,导致 ER 无法激活靶向基因的转录,并促使 ER 蛋白降解。Giredestrant tartrate 可用于治疗肿瘤疾病。 | |||
T11237 |
Camizestrant
Estrogen receptor antagonist 2 |
Estrogen Receptor/ERR | Endocrinology/Hormones |
Camizestrant (Estrogen receptor antagonist 2) 是一种雌激素受体拮抗剂,可用于 ER+ HER2 晚期乳腺癌的研究[1]。 | |||
T4388 |
PHTPP
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
PHTPP 是选择性的雌激素受体 β 拮抗剂,其选择性比 ERα 高 36 倍。 | |||
T7904 |
SR 19881
|
Estrogen/progestogen Receptor | Endocrinology/Hormones |
SR 19881 是 ERRγ 的完全激动剂(结合试验中的 EC50 值为 0.39 μM,基于细胞的试验中 EC50 值为 4.7 μM)。 | |||
T8984 |
FLTX1
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
FLTX1 is a fluorescent derivative of Tamoxifen, designed to efficiently target and label intracellular Tamoxifen-binding sites (estrogen receptors) both under permeabilized and non-permeabilized conditions. Additionally, FLTX1 demonstrates strong antiestrogenic activity in breast cancer cells, resembling the potent antiestrogenic properties of Tamoxifen. Notably, FLTX1 does not exhibit any estrogenic agonistic effect on the uterus. | |||
T7644 |
DPN
Diarylpropionitrile,2,3-双(4-羟苯基)丙腈 |
Apoptosis; Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones |
DPN (Diarylpropionitrile) 是一种非甾体雌激素受体 ERβ选择性配体,其 EC50值为 0.85 nM。DPN 在许多神经系统疾病具有神经保护作用。 | |||
T3975 |
AZD9496
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
AZD9496 是口服有效的选择性雌激素受体降解剂,是一种选择性的雌激素受体拮抗剂(IC50:0.28 nM)。 | |||
T39710 |
ARV-471
Vepdegestrant |
Estrogen Receptor/ERR; PROTACs | Endocrinology/Hormones; PROTAC |
ARV-471 (Vepdegestrant) 是一种高效的,口服有效的基于 Cereblon 配体的雌激素受体降解剂 PROTAC 。ARV-471 常用于研究乳腺癌。 | |||
T7389 |
G15
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
G15 是一种高亲和力的、选择性的 G 蛋白偶联雌激素受体(GPER/GPR30)拮抗剂(Ki:20 nM)。 | |||
T5531 |
GSK-4716
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
GSK-4716 是一种ERRβ/γ选择性激动剂。 | |||
T16566 |
Propyl pyrazole triol
PPT |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Propyl pyrazole triol (PPT) 是雌激素受体 α(ERα)选择性激动剂。它对 ERα 的相对结合亲和力 (ERα: 49%) 比雌激素受体 β (ERβ: 0.12%) 高 410 倍。 | |||
T20625 |
Prochloraz
咪鲜胺,Sporgon,Prelude |
Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal | Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology |
Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用,由此抑制麦角固醇的生物合成,从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和 雄激素受体的拮抗剂,IC50分别为25 μM 和4 μM, 并激活芳烃受体,EC50为1μM。 | |||
T60293 |
Estrogen receptor-IN-1
|
Others | Others |
Estrogen receptor-IN-1 (compound 16) 是有效的雌激素受体(ER)抑制剂,其对 ERα 和 Erβ 的IC50值分别为 13 和 5μM。 | |||
T14987 |
CMP8
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
CMP8 是一种雌激素受体的选择性配体,可结合到雌激素受体配体结合域。它能够作用于突变型 MGERα (IC50:29 nM)、MGRERα (IC50:41 nM)和野生型 hERα (IC50:1100 nM)、hERβ (IC50:2200 nM)。 | |||
T15364 |
G-1
|
Estrogen Receptor/ERR; GPR | Endocrinology/Hormones; GPCR/G Protein |
G-1 是一种高亲和力的、非甾体的、有选择性的 GPR30激动剂(Ki:11 nM)。 | |||
T1216 |
Diethylstilbestrol
Stilbestrol,己烯雌酚,DES |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Diethylstilbestrol (DES) 是一种非甾体雌性激素,能够用于更年期和绝经后的紊乱。 | |||
T62953 |
Estrogen receptor antagonist 6
|
Others | Others |
Estrogen receptor antagonist 6 是一种 Estrogen receptor 的有效拮抗剂。雌激素受体 (Estrogen receptor) 是一种配体激活的转录调节蛋白,能够与内源性雌激素的相互作用,并介导多种生物效应的诱导。Estrogen receptor antagonist 6 具有潜力进行转移性疾病的研究。 | |||
T0593 |
XCT790
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Autophagy | Autophagy; Endocrinology/Hormones |
XCT790 是 ERRα的一种选择性反向激动剂,IC50值为 0.37 μM。它在化疗过程中诱导癌细胞死亡。 | |||
T63582 |
Estrogen receptor antagonist 1
|
Others | Others |
Estrogen receptor antagonist 1 是 estrogen receptor 的有效拮抗剂。其中雌激素 (E2) 和雌激素α受体 (ERα) 是乳腺癌发展的重要驱动因素。Estrogen receptor antagonist 1 对乳腺癌疾病表现出研究潜力。 | |||
T79064 |
Estrogen receptor modulator 7
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
Estrogen receptor modulator7 为一高效雌激素受体调节剂,主要用途涉及癌症研究领域。 | |||
T5633 |
H3B-5942
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
H3B-5942 是不可逆的、选择性的、可口服的雌激素受体共价拮抗剂,能够靶作用于 Cys530,使野生型和突变型ERα失活,能够抑制 ERα 的目标基因GREB1的表达。它具有抗癌活性,对含有 ERαWT 或者突变型 ERα 的肿瘤细胞和动物具有抗肿瘤作用。 | |||
T62311 |
Estrogen receptor β antagonist 2
|
Others | Others |
Estrogen receptor β antagonist 2 是一种选择性的、有效的雌激素受体βestrogen receptor β (ERβ) 拮抗剂,作用于 Erα (IC50: 109.10 μM)和 Erβ (IC50: 0.63 μM)。 | |||
T63277 |
Estrogen receptor antagonist 2
|
Others | Others |
Estrogen receptor antagonist 2 是 estrogen receptor 的选择性下调剂。雌激素 (E2) 和雌激素 α 受体 (ERα) 是乳腺癌发展的重要驱动因素。Estrogen receptor antagonist 2 对乳腺癌疾病具有研究潜力。 | |||
T62952 |
Estrogen receptor antagonist 5
|
Others | Others |
Estrogen receptor antagonist 5 是一种 Estrogen receptor 的有效拮抗剂。雌激素受体 (Estrogen receptor) 是一种配体激活的转录调节蛋白,能够与内源性雌激素的相互作用,并介导多种生物效应的诱导。Estrogen receptor antagonist 5 具有潜力进行转移性疾病的研究。 | |||
T61909 |
Estrogen receptor antagonist 7
|
Others | Others |
Estrogen receptor antagonist7 (compound 13) 是高效ER拮抗剂,能够抑制乳腺癌细胞与卵巢癌细胞生长,展现出抗癌及抗子宫营养活性。 | |||
T3958 |
WAY-200070
WAY 200070 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
WAY-200070 是一种选择性的雌激素受体激动剂(IC50:2.3 nM)。 | |||
T63914 |
Estrogen receptor antagonist 3
|
Others | Others |
Estrogen receptor antagonist 3 是雌激素受体 (ER) 的有效降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。Estrogen receptor antagonist 4 对癌症疾病表现出研究潜力。 | |||
T63106 |
Estrogen receptor antagonist 4
|
Others | Others |
Estrogen receptor antagonist4 是一种有效的雌激素受体 (ER) 降解剂。雌激素信号系统在调节细胞生长、分化和凋亡 (apoptosis) 中发挥着重要作用。Estrogen receptor antagonist4 具有研究癌症疾病的潜力。 | |||
T79109 |
Estrogen receptor modulator 8
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
Estrogen receptor modulator8 (compound 4) 为一口服活性化合物,作用为抑制雌激素受体/ERR α(IC50=0.437 nM,MCF-7 细胞)。此化合物能有效抑制MCF-7细胞的增殖,其IC50值仅为0.1 nM。 | |||
T82439 |
Estrogen receptor modulator 10
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
Estrogen receptor modulator10 (compound G-5b) 是一种具有高亲和力的ER拮抗剂,具有IC50值为6.7 nM,并且是一种有效的降解剂,DC50为0.4 nM。它能够通过蛋白酶体途径实现对ER的快速降解,并能诱导细胞凋亡,同时还能将细胞周期阻滞在G1/G0期,这使其成为癌症研究中的一个重要工具。 | |||
T62764 |
Estrogen receptor α antagonist 1
|
Others | Others |
Estrogen receptor α antagonist 1 (compound 35) 是一种高度选择性的 estrogen receptor α 拮抗剂,作用于 estrogen receptor α (IC50: 0.02 μM),estrogen receptor β (IC50: 6.55 μM) 和 MCF-7 细胞 (IC50: 7.73 μM)。Estrogen receptor α antagonist 1 (compound 35) 能够用于研究肿瘤。 | |||
T6306 |
Erteberel
LY500307 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Erteberel (LY500307) 是一种选择性的雌激素受体 β(ERβ) 激动剂,其Ki=1.54 nM,EC50=3.61 nM。具有抗肿瘤作用。 | |||
T8370 |
GSK5182
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Reactive Oxygen Species | Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB |
GSK5182 是高效选择性,具有口服活性的 ERRγ反向激动剂,其 IC50=79 nM,且不与其他核受体相互作用,包括 ERRα 和 ERα。它还能增加肝癌细胞中 reactive oxyen species (ROS)的产生。 | |||
T13443 |
(R)-Equol
(+)-Equol,R-雌马酚 |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
(R)-Equol ((+)-Equol) 是一种 ERα (Ki:27.4 nM) 和 Erβ (Ki:15.4 nM) 激动剂。 | |||
T6533 |
Hexestrol
Bibenzyl,4,4'-(1,2-二乙基亚乙基)二苯酚,Hexanoestrol,meso-Hexestrol,Hexestrofen |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Hexestrol (Hexanoestrol) 是非甾体合成雌激素,对雌激素受体ERα和ERβ的Ki=均为 0.06 nM。它可增加牛的体重,也可用于雌激素缺乏引起的疾病的研究。 | |||
T13674 |
Elacestrant
依拉司群,RAD1901 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Elacestrant (RAD1901) 是一种具有口服活性的、选择性的雌激素受体 (ER) 降解剂 (SERD),能够作用于 ERα (IC50:48 nM)和 ERβ (IC50:870 nM)。 | |||
T13507 |
4,4'-Iminodiphenol
4-(4-羟基苯胺)苯酚,Leucoindophenol |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
4,4'-Iminodiphenol (Leucoindophenol) 是基于二苯胺骨架的无活性雌激素受体配体。 | |||
T6404 |
Bazedoxifene hydrochloride
Bazedoxifene HCl,盐酸巴多昔芬,TSE-424 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Bazedoxifene hydrochloride (TSE-424) 是一种 IL-6/GP130蛋白相互作用抑制剂,可用于胰腺癌的研究。它也是一种有口服活性的,能透过血脑屏障的,非甾体、选择性的雌激素受体调节剂 (SERM),对 ERα 和 ERβ 作用的 IC50值分别为 26 nM 和 99 nM,可用于研究骨质疏松症。 | |||
T0035 |
Dienestrol
Restrol,双烯雌酚,Dehydrostilbestrol,Dienoestrol,Cycladiene |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Dienestrol (Restrol) 是一种雌激素受体激动剂,是一种合成的非甾体类雌激素,用于对绝经期和绝经后症状的相关研究。 | |||
T7223 |
Gestrinone
R 2323,孕三烯酮 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Gestrinone (R 2323) 是一种合成类固醇激素,能够抑制平滑肌瘤(IC50:43.67 μM),有用于子宫内膜异位症的研究潜力。 | |||
T0168 |
Estradiol (cypionate)
Depofemin,环戊丙酸雌二醇,Estradiol cypionate |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Estradiol cypionate (Depofemin) 是一种 Estradiol 的 17β-环戊丙酸酯,能够作用于雌激素受体。抑制ET-1的合成。 | |||
T7313 |
Enclomiphene citrate
恩氯米芬柠檬酸盐,Enclomifene citrate,(E)-Clomiphene citrate,trans-Clomiphene citrate |
Estrogen Receptor/ERR | Endocrinology/Hormones |
Enclomiphene citrate (trans-Clomiphene citrate) 是口服具有活力的 oestrogen receptor 拮抗剂,具有抗雌激素活性。 | |||
T2567 |
Etonogestrel
3-Oxodesogestrel,3-keto-Desogestrel,依托孕烯,Nexplanon,Implanon |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Progesterone Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism; Others |
Etonogestrel (Implanon) 是孕激素去氧孕烯的生物活性代谢物,与靶器官中的孕酮受体和雌激素受体高亲和力地结合,可诱导FKBP51mRNA 和蛋白表达。它是一种甾体孕激素,用作激素避孕药。 | |||
T8981 |
WAY-169916
WAY 169916,WAY169916 |
NF-κB | NF-κB |
WAY-169916 是雌激素受体 (ER) 的通路选择性抑制剂。它通过抑制 NF-kB 转录活性而发挥作用,但没有常规的雌激素活性。 | |||
T4420 |
4-Hydroxytamoxifen
ICI 79280,(Z)-4-hydroxy Tamoxifen,4-羟基他莫昔芬,trans-4-Hydroxytamoxifen |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
4-Hydroxytamoxifen (ICI 79280) 是 Tamoxifen 的活性代谢产物,是一种雌激素受体调节剂 (SERM),具有选择性和口服有效性。4-Hydroxytamoxifen 具有抗肿瘤活性,可用于乳腺癌的研究。 | |||
T0384 |
Estradiol benzoate
Benzoestrofol,Benzhormovarine,苯甲酸雌二醇,Benovocylin |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Estradiol benzoate (Benzhormovarine) 是一种类固醇性激素,是一种雌二醇的前体药物。它表现出轻微的合成代谢特性,增加血液凝固性。 | |||
T5835 |
PROTAC ERRα ligand 2
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
PROTAC ERRα ligand 2 是雌激素相关受体 α (ERRα)反向激动剂。它对 ERRα (IC50=5.67 nM) 的抑制作用比 XCT790 (IC50=61.3 nM) 高效约 11 倍。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1052 |
Lindleyin
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Lindleyin 是从 Rhei rhizoma 中分离得到,通过雌激素受体介导激素作用。它能够与 ERα结合,有类似雌激素的作用。 | |||
T5S0543 |
Isocurcumenol
|
Apoptosis; Estrogen Receptor/ERR; Reductase | Apoptosis; Endocrinology/Hormones; Metabolism |
Isocurcumenol 是从莪术中分离得到的一种天然产物,是一种ERα抑制剂,对 DLA 和 KB 癌细胞的IC50分别为 99.1 µg/mL 和 178.2 µg/mL,具有抗肿瘤活性。 | |||
T13768 |
(+)-Medicarpin
|
Estrogen/progestogen Receptor | Endocrinology/Hormones |
(+)-Medicarpin, a pterocarpan, is an isoflavonoid compound derived from multiple medicinal plant species such as Sophora japonica, Zollernia paraensis, Platymiscium yucatamun, Machaerium aristulatum, and Platymiscium floribundum. It exhibits potent inhibition of osteoclastogenesis and facilitates bone healing and increased bone mass through osteoblast differentiation, which is mediated by the estrogen receptor (ER) β. | |||
T3665 |
Tectoridin
射干苷,Shekanin |
Estrogen Receptor/ERR; Reductase | Endocrinology/Hormones; Metabolism |
Tectoridin (Shekanin) 是分离自 Maackia amurensis 中的异黄酮,是一种植物雌激素,能够激活雌激素和甲状腺激素受体。它通过 ER 依赖性基因组途径和 GPR30 依赖性非基因组途径发挥雌激素作用。 | |||
T3855 |
Tracheloside
|
Estrogen Receptor/ERR; Phosphorylase | Endocrinology/Hormones; Metabolism |
Tracheloside 是抗雌激素木质素,利用 ERK1/2 刺激促进角质形成细胞增殖,是一种良好的促进伤口愈合的药物。 | |||
T0301 |
Ethisterone
炔孕酮,17α-Ethynyltestosterone,Pregneninolone |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Ethisterone (17α-Ethynyltestosterone) 是一种口服活性类固醇避孕药,是一种合成类固醇雌激素。据报道,它具有雄激素活性,用于妇科疾病的研究。 | |||
T13542 |
α-Zearalenol
|
Estrogen Receptor/ERR | Endocrinology/Hormones |
α-Zearalenol 是一种霉菌毒素,对雌激素受体具有高亲和力。它是 zearalenone (ZEN) 的一种衍生物,由于其异种雌激素效应可引起动物的生殖障碍。 | |||
T3913 |
Saikosaponin D
|
Estrogen Receptor/ERR; NF-κB; Antibacterial; STAT | Endocrinology/Hormones; JAK/STAT signaling; Microbiology/Virology; NF-κB; Stem Cells |
Saikosaponin D 是一种从柴胡中分离到的三萜皂苷类天然产物,具有抗炎,抗菌,抗肿瘤,抗过敏作用。它抑制 selectin,STAT3和 NF-kB 的活性,活化estrogen receptor-β。 | |||
TQ0295 |
Coumestrol
拟雌内酯,考迈斯托醇 |
Estrogen Receptor/ERR | Endocrinology/Hormones |
Coumestrol 是一种大豆产品中存在的植物雌激素。它抑制ES2细胞增殖的IC50值为50 μM。它可用于癌症,神经障碍和自身免疫疾病的研究。 | |||
T3325 |
Liquiritigenin
4',7-Dihydroxyflavanone,甘草素 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Liquiritigenin (4',7-Dihydroxyflavanone) 是一种黄烷酮,从甘草中分离得到,是高度选择性的雌激素受体β 激动剂,用于活化 ERE tk-Luc 的 EC50值为36.5 nM。 | |||
T4000 |
(±)-Equol
Equol,(±)-雌马酚,(R,S)-Equol |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Drug Metabolite | Endocrinology/Hormones; Metabolism |
(±)-Equol ((R,S)-Equol) 是 equol 的外消旋体。它对 ERα 和 ERβ 的 EC50s of 分别为 200 和 74 nM。Equol 是大豆异黄酮黄豆苷和大豆黄素的代谢产物。 | |||
T3846 |
Bavachin
Corylifolin,补骨脂甲素,补骨脂二氢黄酮 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Bavachin (Corylifolin) 是一种从补骨脂种子中分离到的黄酮类物质,能够激活雌性激素受体 ERα (EC50:320 nM) 和 ERβ (EC50:680 nM)。 | |||
T1009 |
Estrone
Oestrone,雌酮,Fluoroethyl,Aquacrine |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Estrone (Aquacrine) 是内源性雌激素的主要代表,由多种组织产生,尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。 | |||
TMA1644 |
Segetalin B
王不留行环肽B,王不留行环肽 B |
Estrogen Receptor/ERR | Endocrinology/Hormones |
Segetalin B 是一种环五肽,可从Vaccaria segetalis 分离得到,具有类雌激素活性。 | |||
T1571 |
Estriol
NSC-12169,Oestriol,雌三醇 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; MRP; Endogenous Metabolite | Endocrinology/Hormones; Immunology/Inflammation; Metabolism |
Estriol (Oestriol) 是G 蛋白偶联雌激素受体拮抗剂,能够作用于雌激素受体阴性乳腺癌细胞。 | |||
T3840 |
Dihydroresveratrol
3,4',5-Trihydroxybibenzyl,二氢白藜芦醇,二氢藜芦醇 |
Estrogen Receptor/ERR; Others | Endocrinology/Hormones; Others |
Dihydroresveratrol (3,4',5-Trihydroxybibenzyl) 是一种激素受体调节剂,是一种植物雌激素。它在皮摩尔和纳摩尔浓度下促进前列腺和乳腺癌细胞增殖。 | |||
T2810 |
(20S)-Protopanaxatriol
原人参三醇,20(S)-APPT,20 (S)-原人参三醇,g-PPT |
Apoptosis; Estrogen Receptor/ERR; Glucocorticoid Receptor; Estrogen/progestogen Receptor; Liver X Receptor | Apoptosis; Endocrinology/Hormones; Metabolism |
(20S)-Protopanaxatriol (g-PPT) 是人参皂苷的代谢物,通过糖皮质激素受体和雌激素受体起作用,同时为LXRα的抑制剂,具有广泛的抗癌活性。 | |||
T3385 |
Gypenoside XVII
GP-17,Gynosaponin S,七叶胆苷XVII |
Estrogen Receptor/ERR; GSK-3; Endogenous Metabolite | Endocrinology/Hormones; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells |
Gypenoside XVII (Gynosaponin S) 是一种绞股蓝皂甙类的新型植物雌激素,能够激活雌激素受体。 | |||
T2837 |
Chrysin
5, 7-Dihydroxyflavone,NSC 407436,白杨素,5,7-Dihydroxyflavone |
Estrogen Receptor/ERR; Antioxidant | Endocrinology/Hormones; oxidation-reduction |
Chrysin (5,7-Dihydroxyflavone) 是一种雌激素阻断剂。 | |||
T2177 |
Kaempferol
Kempferol,山柰酚,山奈酚,Robigenin |
Apoptosis; Estrogen Receptor/ERR; Mitophagy; Estrogen/progestogen Receptor; HIV Protease; Endogenous Metabolite; Parasite; Autophagy | Apoptosis; Autophagy; Endocrinology/Hormones; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Kaempferol (Robigenin) 属于天然类黄酮,是一种 ERRα 和 ERRγ 的反向激动剂。Kaempferol 具有抗肿瘤、抗炎、抗氧化、抗菌和抗病毒等多种活性。 | |||
T1048 |
Estradiol
雌二醇,E2,17β-Estradiol,17β-Oestradiol,β-Estradiol |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Estradiol (E2) 是一种天然的类固醇性激素,对于女性生育能力和第二性征的维持至关重要。Estradiol 通过雌激素受体 β (ERβ) 上调 IL-6 表达。 | |||
T0760 |
Cholesterol
Cholesterin,Cholesteryl alcohol,胆固醇 |
Estrogen Receptor/ERR; MRP; Endogenous Metabolite; ROR | Endocrinology/Hormones; Immunology/Inflammation; Metabolism |
Cholesterol (Cholesteryl alcohol) 属于天然产物,是哺乳动物中的主要固醇,是一种雌激素相关受体 α (ERRα) 的激动剂。Cholesterol 广泛存在于动物的细胞膜,也是合成几种重要荷尔蒙及胆酸的材料。 | |||
TQ0274 |
27-Hydroxycholesterol
27-羟基胆固醇,5,25R-胆甾烯-3BETA,26-二醇,25(R)-27-hydroxy Cholesterol |
Estrogen/progestogen Receptor; Liver X Receptor | Endocrinology/Hormones; Metabolism |
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) 是一种有效的、选择性的雌激素受体调节剂和肝X 受体激动剂。 | |||
T6491 |
(-)-(S)-Equol
(−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
(-)-(S)-Equol (4',7-Dihydroxyisoflavan) 是雌激素受体β的高亲和力配体。 | |||
T1424 |
Ethynyl estradiol
乙炔基雌二醇,17α-Ethynylestradiol,Ethinyl Estradiol,炔雌醇 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Ethynyl estradio 是一种高效的生物活性雌激素。 | |||
T36857 |
Estrone sulfate sodium
雌酮3-硫酸钠,Estrone 3-sulfate (sodium salt),17β-Estrone 3-sulfate |
Endogenous Metabolite | Metabolism |
Estrone sulfate sodium (17β-Estrone 3-sulfate) 是一种主要的循环血浆雌激素,无生物活性,通过类固醇硫酸酯酶(STS) 转化为生物活性雌激素雌酮。 | |||
T0345 |
Estropipate
雌酮硫酸酯哌嗪,Piperazine estrone sulfate,Pipestrone,Estrone sulfate piperazine salt |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor | Endocrinology/Hormones |
Estropipate (Piperazine estrone sulfate) 是一种由硫酸雌酮和哌嗪组成的天然雌激素物质。 | |||
T3806 |
kaempferide
Kaempferol 4'-O-methyl ether,山奈素,Kaempferol 4'-methyl ether,4'-Methylkaempferol,4'-O-Methylkaempferol |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Influenza Virus; Antibacterial; Autophagy | Autophagy; Endocrinology/Hormones; Microbiology/Virology |
kaempferide (4'-Methylkaempferol) 是一种存在于山柰中的O-甲基化黄酮醇,具有抗病毒活性。 | |||
T1549 |
Raloxifene hydrochloride
LY156758 hydrochloride,盐酸雷洛昔芬,Raloxifene HCl,LY139481 hydrochloride,Keoxifene hydrochloride,LY156758 (Keoxifene) HCl |
Estrogen Receptor/ERR; Others; MAO; Estrogen/progestogen Receptor; Autophagy | Autophagy; Endocrinology/Hormones; Metabolism; Neuroscience; Others |
Raloxifene hydrochloride (LY156758 hydrochloride) 是一种选择性且可口服的雌激素受体调节剂,用于预防绝经后妇女的骨质疏松症。它对骨骼和胆固醇代谢具有雌激素激动作用,但对乳腺和子宫组织具有完全的雌激素拮抗作用。 | |||
T2882 |
Genistin
染料木甙,Genistoside,Genistein glucoside,Genistein 7-glucoside,Genistine,Genistein 7-O-β-D-glucopyranoside,染料木苷 |
Apoptosis; Estrogen Receptor/ERR; Others | Apoptosis; Endocrinology/Hormones; Others |
Genistin (Genistoside) 是一种植物雌激素家族的异黄酮,是一种抗脂肪生成剂。它通过调节ERalpha 信号通路抑制乳腺癌细胞生长和促进凋亡细胞死亡。 | |||
T7299 |
β-Estradiol 17-acetate
β-雌二醇 17-乙酸酯,17-乙酸-17-BETA-雌二酯,beta-estradiol 17-acetate,1,3,5(10)-Estratriene-3,17β-diol 17-acetate |
Estrogen Receptor/ERR; Others | Endocrinology/Hormones; Others |
β-Estradiol 17-acetate (1,3,5(10)-Estratriene-3,17β-diol 17-acetate) 是一种雌二醇代谢物。 | |||
T15248 |
Estetrol
Donesta |
Estrogen Receptor/ERR; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Estetrol(Donesta) 是可口服且具有选择性核雌激素受体 (estrogen receptor) 调节剂,是一种在怀孕期间由人类胎儿肝脏合成的天然雌激素。Estetrol 对子宫内膜或中枢神经系统有作用,但对乳房有拮抗作用。Estetrol 在低浓度时可能有助于降低血栓形成。Estetrol 可用于缓解更年期症状。 | |||
T3717 |
Hinokitiol
4-Isopropyltropolone,桧木醇,β-thujaplicin,β-桧木醇 |
DNA Methyltransferase; Virus Protease; Estrogen/progestogen Receptor; Nrf2 | Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; Microbiology/Virology |
Hinokitiol (4-Isopropyltropolone) 是从日本扁柏中分离到的一种挥发油成分,可抑制紫外线 B 诱导的角质形成细胞凋亡,可调节雌激素受体信号传导并抑制人乳腺癌细胞的增殖。它具有抗感染、抗氧化及抗肿瘤等活性。 | |||
T3923 |
Calycosin
Cyclosin,3'-Hydroxyformononetin,异黄酮,毛异黄酮 |
Apoptosis; Tyrosinase | Apoptosis; Proteases/Proteasome |
Calycosin (Cyclosin) 是一抗氧化和抗炎症活性天然产物。 | |||
TN1567 |
Delphinidin chloride
|
Estrogen Receptor/ERR; VEGFR | Angiogenesis; Endocrinology/Hormones; Tyrosine Kinase/Adaptors |
Delphinidin chloride 是一种花青素,是一种可从浆果和红酒中分离得到的天然植物色素,是某些花青素的前体。Delphinidin chloride 诱导血管内皮释放一氧化氮,引起血管松弛。在1 ~ 40 μM 剂量下,对上皮生长因子受体的信号传导和雌激素受体α的表达有抑制作用,与细胞凋亡和自噬有关。Delphinidin chloride 能调节 JAK/STAT3 和 MAPKinase 信号传导。Delphinidin 还能抑制 p300/CBP 的组蛋白乙酰转移酶活性(IC50 在约为30 μM) | |||
T36914 |
2-Hydroxyanthraquinone
|
Others | Others |
2-Hydroxyanthraquinone 是一种天然产物,显示出抗肿瘤和免疫抑制活性。 | |||
T39003 |
4',2-Dihydroxy-4,6-dimethoxydihydrochalcone
|
Others | Others |
4',2-Dihydroxy-4,6-dimethoxydihydrochalcone, an estrogen agonist, exhibits a significant binding affinity for the estrogen receptor in bovine uterine tissue, with an IC50 value of 15 μM. | |||
TN4383 |
Kazinol U
|
IL Receptor; IκB/IKK; NOS; NF-κB | Immunology/Inflammation; NF-κB |
Kazinol U may have therapeutic value in delaying pancreatic β-cell destruction in type 1 diabetes by blocking the NF-κB pathway in pancreatic β-cells reduces cell damage. Kazinol U shows estrogenic activity with ligand-activity of estrogen receptor, transcriptional activity of estrogen -responsive element-reporter genes, it may have beneficial effects in the treatment of menopausal symptoms. | |||
TN6366 |
Lupinalbin A
鲁冰花 |
||
Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathw | |||
TN5456 |
Isoerysenegalensein E
|
||
Isoerysenegalensein E shows anti-estrogenic activity comparable to that of 4-hydroxytamoxifen, a typical estrogen receptor antagonist. It shows significant cytotoxicity against HL-60 cells, it induces apoptosis in HL-60 cells through activation of the cas | |||
TN3539 | Broussonin A | ERK; IL Receptor; IκB/IKK; NOS; NF-κB; Akt | Cytoskeletal Signaling; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling |
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c | |||
TN5164 |
trans-Hinokiresinol
|
IL Receptor; TNF; NOS; LTR | Apoptosis; Immunology/Inflammation |
Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphylaxis reaction. Hinokiresinol (trans-hinokiresinol) and nyasol (cis-hinokiresinol) are estrogen | |||
TMA0424 |
Martynoside
|
ROS | Immunology/Inflammation |
Martynoside is a natural selective estrogen receptor modulator, which has antioxidative, anti-muscle fatigue, anticancer and antimetastatic activities. Martynoside has the potential of antagonizing sports anaemia, the mechanism of this effect might be rel | |||
TN3802 |
Dehydrodiconiferyl alcohol
|
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Dehydrodiconiferyl alcohol (DHCA) 是一种从葫芦中分离出来的木脂素,通过作为雌激素受体激动剂抑制破骨细胞分化和卵巢切除术诱导的骨质流失。 | |||
T35667 |
Napyradiomycin A1
Napyradiomycin A1 |
Others | Others |
Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus,M. luteus,B. anthracis,C. bovis, andM. smegmatis(MICs = 1.56-12.5 μg/ml).1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 μM in rat uterine homogenates).2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 μM... | |||
TN3084 |
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone
|
Estrogen Receptor/ERR; Others | Endocrinology/Hormones; Others |
5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone 具有抗癌活性,体外对 ER 阳性乳腺癌MCF-7细胞表现出较强的抗增殖作用,对MCF-7细胞的IC50值为4.41 uM。5,7,3',4'-Tetrahydroxy-3-methoxy-8,5'-diprenylflavone 能显著下调雌激素受体-α (ER-α)的表达浓度,并能抑制人乳腺癌细胞系BCAP-37异种移植模型体内的肿瘤生长。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00762 |
ER alpha Protein, Human, Recombinant (His)
Estrogen Receptor,ER α,estrogen <... |
Human | E. coli |
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as ... | |||
TMPH-02142 |
ERR1 Protein, Human, Recombinant (GST)
Steroid hormone receptor ERR1,Estrogen |
Human | E. coli |
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. | |||
TMPH-01305 |
ER beta Protein, Human, Recombinant (His)
Nuclear receptor subfamily 3 group A member 2,E... |
Human | P. pastoris (Yeast) |
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 61.1 kDa and the accessio... | |||
TMPH-01304 |
ER beta Protein, Human, Recombinant (E. coli, His)
ESR2,Nuclear receptor subfamily 3 group A member 2,... |
Human | E. coli |
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight... | |||
TMPY-03496 |
EBAG9 Protein, Human, Recombinant (His)
EB9,PDAF,estrogen receptor binding site as... |
Human | E. coli |
RCAS1, also known as EBAG9, is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. RCAS1 gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of RCAS1 gene. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for RCAS1 gene. EBAG9 may participate in s... | |||
TMPY-04396 |
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor t... |
Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... | |||
TMPY-01660 |
SULT1E1 Protein, Human, Recombinant (His)
ST1E1,EST,sulfotransferase family 1E member 1,EST-1,STE,MGC3... |
Human | E. coli |
Estrogen sulfotransferase, also known as Sulfotransferase, estrogen-preferring, Sulfotransferase 1E1, SULT1E1 and ST1E1, is a cytoplasm enzyme that belongs to the sulfotransferase 1 family. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. SULT1E1 may control the level of the estrogen receptor by sulfurylating free estradio... | |||
TMPJ-00705 |
BCAS2 Protein, Human, Recombinant (His, T7)
BCAS2,DNA Amplified in Mammary Carcinoma 1 Protein,Pre-mRNA-... |
Human | E. coli |
Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell lines. BCAS2 is a component of the spliceosome, taking part in the removal of introns from mRNA precursors. BCAS2 interacts with estrogen receptor alpha and beta, thyroid hormone receptor beta, peroxisome proliferator-activated receptor gamma. BCAS2 functions as an ER co-activator ... | |||
TMPJ-00056 |
AG-2 Protein, Human, Recombinant (His)
HPC8,AG2,AG-2,hAG-2,Anterior Gradient Protein 2 Homolog,AGR2... |
Human | HEK293 Cells |
Anterior Gradient 2 (AGR2) is an 18-21 kDa member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells, such as small intestine goblet, prostate epithelium, enteroendocrine cells, and multiple carcinoma cell types. AGR2 forms transient disulfide linkages with molecules destined for secretion, possibly aiding protein folding. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of E... | |||
TMPJ-00253 |
OPG Protein, Mouse, Recombinant (His)
Opg,Ocif,Tnfrsf11b,Osteoclastogenesis inhibitory factor,Oste... |
Mouse | HEK293 Cells |
Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells, fibroblasts and endothelial cells. Regulation of its expression by estrogen, parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it, while OPG ... | |||
TMPY-04422 |
Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)
CK1g2,casein kinase 1, γ2,casein kinase 1, gamma 2,Casein Ki... |
Human | Baculovirus Insect Cells |
Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha, beta, gamma, and delta). Dishevelled (Dsh), another positive component of the Wnt pathway, becomes phosphorylated in response to Wnt signals. All the CKI isoforms, with the exce... | |||
TMPY-02214 |
OTUB1 Protein, Human, Recombinant (His)
OTU deubiquitinase, ubiquitin aldehyde binding 1,OTB1,HSPC26... |
Human | E. coli |
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytoplasm protein that belongs to the peptidase C65 family. OTUB1 is a hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. OTUB1 is a regulator of T-cell anergy, a phenomenon that... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12329 |
Ospemifene D4
FC-1271a D4 |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor. | |||
T13076 |
Tamoxifen-d5
ICI 47699-d5,(Z)-Tamoxifen-d5,trans-Tamoxifen-d5 |
HSP | Cytoskeletal Signaling; Metabolism |
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity. | |||
TMIJ-0028 |
17β-Estradiol-2,4-d2
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17β-Estradiol-2,4-d2 是 17β-Estradiol 的氘代化合物。17β-Estradiol 的 CAS 号为 50-28-2。Estradiol 是一种类固醇性激素,对于女性生育能力和第二性征的维持至关重要。它通过雌激素受体 β 途径上调 IL-6 表达。 | |||
TMID-0055 |
17β-estradiol-d4
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17β-estradiol-d4 是 17β-estradiol 的氘代化合物。17β-estradiol 的 CAS 号为 50-28-2。Estradiol 是一种类固醇性激素,对于女性生育能力和第二性征的维持至关重要。它通过雌激素受体 β 途径上调 IL-6 表达。 | |||
TMIJ-0032 |
17beta-Estradiol-13C2
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17beta-Estradiol-13C2 是 17beta-Estradiol 的 13C 的标记化合物。17beta-Estradiol 的 CAS 号为 50-28-2。Estradiol 是一种类固醇性激素,对于女性生育能力和第二性征的维持至关重要。它通过雌激素受体 β 途径上调 IL-6 表达。 | |||
TMID-0024 |
Dienestrol-d6
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Dienestrol-d6 是 Dienestrol 的氘代化合物。Dienestrol 的 CAS 号为 84-17-3。Dienestrol 是一种雌激素受体激动剂,是一种合成的非甾体类雌激素,用于对绝经期和绝经后症状的相关研究。 | |||
TMID-0108 |
17β-Estradiol-2,4,16,16,17-d5
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17β-Estradiol-2,4,16,16,17-d5 是 17β-Estradiol 的氘代化合物。17β-Estradiol 的 CAS 号为 50-28-2。Estradiol 是一种类固醇性激素,对于女性生育能力和第二性征的维持至关重要。它通过雌激素受体 β 途径上调 IL-6 表达。 | |||
TMIJ-0196 |
17β-Estradiol-16,16,17-d3
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17β-Estradiol-16,16,17-d3 是 17β-Estradiol 的氘代化合物。17β-Estradiol 的 CAS 号为 50-28-2。Estradiol 是一种类固醇性激素,对于女性生育能力和第二性征的维持至关重要。它通过雌激素受体 β 途径上调 IL-6 表达。 | |||
TMIJ-0040 |
17alpha-Estradiol-2,4-d2
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17alpha-Estradiol-2,4-d2 是 17alpha-Estradiol 的氘代化合物。17alpha-Estradiol 的 CAS 号为 57-91-0。17α-Estradiol 是一种雌性激素,可抑制5α-reductase,在雄原性脱发的研究中有潜力。 | |||
TMIJ-0244 |
Fulvestrant-d3
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Fulvestrant-d3 是 Fulvestrant 的氘代化合物。Fulvestrant 的 CAS 号为 129453-61-8。Fulvestrant是纯抗雌激素,也是一种雌激素受体拮抗剂,IC50为 9.4 nM。它抑制ER阳性 MCF-7 细胞的生长,IC50为 0.29 nM。它还是一种GPR30的激动剂。它可诱导细胞自噬和凋亡,有抗肿瘤作用。 | |||
T35783 |
Zearalenone-13C18
Zearalenone-13C18 |
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Zearalenone-13C18is intended for use as an internal standard for the quantification of zearalenone by GC- or LC-MS. Zearalenone is a mycotoxin that has been found inFusariumand has estrogenic activities.1It binds to human estrogen receptor α (ERα) and ERβ (IC50s = 9 and 5.8 nM, respectively).2Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs.3Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also i... |