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Search Results for " androgen "

Targets Recommended: Androgen Receptor Others

202

抑制剂 & 化合物

32

天然产物

1

化合物库

25

重组蛋白

11

同位素标记化合物

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Cat. No.	Product Name
L2195	抗前列腺癌化合物库		2070 compounds
	2070 种与前列腺癌相关的化合物，可以用于高通量和高内涵筛选

化合物库

抗前列腺癌化合物库

Cat.No: L2195

Compounds: 2070

Cat. No.	Product Name	Target	Signaling Pathways
T10320	Androgen receptor antagonist 1	Others	Others
	Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, which results in 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively.
T72985	Masofaniten Androgen receptor-IN-2	Others	Others
	Masofaniten (Androgen receptor-IN-2) 是一种有效的、具有口服活性的androgen receptor 抑制剂。Masofaniten 对前列腺癌具有抗肿瘤活性。
T79891	Androgen receptor degrader-3	Androgen Receptor	Endocrinology/Hormones
	Androgen receptordegrader-3是选择性雄激素受体降解剂，具有阻断雄激素受体信号传导并降解受体本体的能力，适用于前列腺癌疾病研究。
T60987	Androgen receptor antagonist 3	Others	Others
	Androgen receptor antagonist 3 (Compound C18) 具有抗癌活性。它是雄激素受体 (AR) 的拮抗剂 (IC50 = 2.4 μM)。
T80647	Androgen receptor degrader-2	Androgen Receptor	Endocrinology/Hormones
	Androgen Receptordegrader-2 (compound 9) 为有效雄激素受体降解剂，适用于癌症研究。
T80633	Androgen receptor degrader-1	Androgen Receptor	Endocrinology/Hormones
	Androgen receptor degrader-1 (compound 18)作为高效的雄激素受体降解剂, 主要应用于癌症研究。
T60988	Androgen receptor antagonist 4	Others	Others
	Androgen receptor antagonist 4 (Compound AT2) 表现出抗癌活性。Androgen receptor antagonist 4 有效拮抗 AR 的转录活性，抑制 AR 的下游靶基因，并阻断 DHT 诱导的 AR 核转位。它是雄激素受体 (AR) 的拮抗剂 (IC50 = 0.15 μM)。
T79024	Androgen receptor-IN-5	Androgen Receptor	Endocrinology/Hormones
	Androgen Receptor-IN-5 为雄激素受体 (androgen receptor) 抑制剂，显示出有效的抗肿瘤活性。它亦能够抑制IL-17A、IL-17F及INF-γ的生成。
T83119	Androgen receptor antagonist 9	Androgen Receptor	Endocrinology/Hormones
	安德罗根受体拮抗剂9（化合物28）作为雄激素受体的对抗物，阻断了该受体的活性。
T63324	Androgen receptor antagonist 5	Others	Others
	Androgen receptor antagonist 5 是雄激素受体 (AR) 的有效拮抗剂 (IC50: 6.17 μM)。Androgen receptor antagonist 5 能够有效损害 AR 核转位，减少细胞核 AR 水平，扰乱 AR 介导的基因调控。Androgen receptor antagonist 5 对前列腺癌细胞 LNCaP 的增殖具有抑制作用，并在 LNCaP 异种移植小鼠模型中显示出抗肿瘤效果，能够用于研究前列腺癌症。
T0380	Bicalutamide 比卡鲁胺,ICI-176334	Androgen Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	Bicalutamide (ICI-176334) 是一种具有口服活性的非甾体雄激素受体拮抗剂，可研究前列腺癌。
T12928	SK33	Androgen Receptor	Endocrinology/Hormones
	SK33 是一种有效的组织选择性抗雄激素药物，是一种肌醇类似物，能够降低雄激素受体 (AR) 的转录活性。
T9035	Testosterone undecanoate	Others; Androgen Receptor	Endocrinology/Hormones; Others
	Testosterone undecanoate 是一种睾酮酯，是睾酮的代谢产物，睾酮是很有前途的男性激素避孕雄激素。
T22263	Bavdegalutamide ARV-110	Androgen Receptor	Endocrinology/Hormones
	Bavdegalutamide (ARV-110) 是一种雄激素受体 (AR) 的 PROTAC 降解剂。 Bavdegalutamide 可用于前列腺癌的研究。 Bavdegalutamide 具有口服活性和选择性，并促进 AR 的泛素化和降解。
T9246	JNJ-63576253	Androgen Receptor	Endocrinology/Hormones
	JNJ63576253 是具有口服活性的、有效的雄激素受体的完全拮抗剂，在 LNCaP 细胞中对 F877L 突变型 AR 和野生型 AR 的IC50值分别为 37 和 54 nM。它可用于研究去势抵抗性前列腺癌。
T6829	EPI-001 EPI001,EPI 001	Apoptosis; Androgen Receptor; PPAR	Apoptosis; DNA Damage/DNA Repair; Endocrinology/Hormones; Metabolism
	EPI-001 是一种选择性雄激素受体 (AR) 的抑制剂，靶向 AR 的反式激活单元 5，可抑制 AR 氨基末端结构域的反式激活，IC50值约为 6 μM。它也是一种选择性的PPARγ调节剂，对去势抵抗性前列腺癌具有活性。
T14116	ACP-105	Androgen Receptor	Endocrinology/Hormones
	ACP-105 是选择性的、可口服的雄激素受体调节剂 , 能够作用于野生型 AR (pEC50:9.0)和 T877A 突变型 AR (pEC50:9.3)。
T12323	ORM-15341	Androgen Receptor	Endocrinology/Hormones
	ORM-15341 是雄激素受体拮抗剂，作用于 AR-HEK293细胞(IC50:38 nM)。
T13272	UT-155	Androgen Receptor	Endocrinology/Hormones
	UT-155 是雄激素受体选择性拮抗剂，能够与 AR-LBD 结合(Ki:267 nM)。
T26539	AC-262536 AC262536,4-(3-内型-羟基-8-氮杂双环[3.2.1]辛烷-8-基)萘-1-甲腈	Androgen Receptor	Endocrinology/Hormones
	AC-262536 是非甾体雄激素受体选择性调节剂，具有有益的合成代谢作用。它可以强效激动雄激素受体，亲和力为1-10 nM。
T7690	2-hydroxy Flutamide	Androgen Receptor	Endocrinology/Hormones
	2-hydroxy Flutamide 是 Flutamide 的活性代谢物，是雄激素受体拮抗剂，其 IC50值为700 nM。它可用于研究前列腺癌。
T3618	GSK-2881078 GSK2881078,GSK 2881078	Androgen Receptor	Endocrinology/Hormones
	GSK-2881078 是雄激素受体调节器，可用于精神萎顿的研究。
T2339	Apalutamide ARN-509	Androgen Receptor; GABA Receptor	Endocrinology/Hormones; Membrane transporter/Ion channel; Neuroscience
	Apalutamide (ARN-509) 是一种有效、竞争性的雄激素受体 (AR) 拮抗剂(IC50:16 nM)。
T20625	Prochloraz 咪鲜胺,Sporgon,Prelude	Estrogen Receptor/ERR; AhR; Androgen Receptor; Antifungal	Endocrinology/Hormones; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用，由此抑制麦角固醇的生物合成，从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和雄激素受体的拮抗剂，IC50分别为25 μM 和4 μM，并激活芳烃受体，EC50为1μM。
T8933	JNJ-63576253 free base TRC253,JNJ-63576253	Androgen Receptor	Endocrinology/Hormones
	JNJ-63576253 free base (TRC253) 是具有口服活性的、有效的雄激素受体的完全拮抗剂，在 LNCaP 细胞中对 F877L 突变型 AR 和野生型 AR 的 IC50值分别为 37 和 54 nM。它可用于研究去势抵抗性前列腺癌 (CRPC) 。
T39695	ARD-2128	Androgen Receptor; PROTACs	Endocrinology/Hormones; PROTAC
	ARD-2128 是高效的雄激素受体降解剂 PROTAC。它可有效降低雄激素受体蛋白并抑制肿瘤组织中雄激素受体调节的基因，在没有毒性迹象的情况下抑制肿瘤生长。它有用于前列腺癌研究的价值。
T8217	Enzalutamide carboxylic acid	Androgen Receptor; Drug Metabolite	Endocrinology/Hormones; Metabolism
	Enzalutamide carboxylic acid 是 Enzalutamide 非活性代谢物。Enzalutamide 是雄激素受体 (AR) 拮抗剂。
T21740	RD162	Androgen Receptor	Endocrinology/Hormones
	RD162 是一种与雄激素受体 (AR) 特异性结合的非甾体抗雄激素 (NSAA)。
T5100	DJ-V-159 DJ-V159	GPR; Androgen Receptor	Endocrinology/Hormones; GPCR/G Protein
	DJ-V-159 (DJ-V159) 是一种G 蛋白偶联受体家族C 组6 A 的激动剂。
T0489	Flutamide SCH 13521,氟他胺	Androgen Receptor	Endocrinology/Hormones
	Flutamide (SCH 13521) 是一种抗雄激素化合物，在啮齿动物和犬科动物中的效力与环丙孕酮大致相同。
T6400	AZD3514	Androgen Receptor	Endocrinology/Hormones
	AZD3514 是一种口服雄激素受体下调剂(Ki :2.2 μM)，能够减少 AR 蛋白表达。
T6889	MI-136	Apoptosis; Epigenetic Reader Domain; Androgen Receptor	Apoptosis; Chromatin/Epigenetic; Endocrinology/Hormones
	MI136 是 menin-MLL(PPI) 蛋白互作的抑制剂，其 IC50值为31 nM，Kd 值为23.6 nM。它可抑制 DHT 诱导的雄激素受体 (AR) 靶基因的表达，有用于去势抵抗性肿瘤的潜能。
T6002	Enzalutamide MDV3100,恩杂鲁胺	Androgen Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	Enzalutamide (MDV3100) 是一种雄激素受体 (AR) 拮抗剂 (IC50=36 nM in LNCaP)。Enzalutamide 可以激活自噬，具有抗肿瘤活性，常用于去势抵抗性前列腺癌的治疗。
T13273	UT-34	Androgen Receptor	Endocrinology/Hormones
	UT-34 是选择性的、具有口服活性的泛雄激素受体拮抗剂和降解剂，能够作用于野生型 AR (IC50:211.7 nM)、F876L-AR (IC50:262.4 nM)、W741L-AR (IC50:215.7 nM)。它与配体结合结构域和功能 1结构域结合，并需要泛素蛋白酶体途径来降解AR。它有抗前列腺癌的能力。
T6915	Darolutamide ODM-201,BAY-1841788	Androgen Receptor	Endocrinology/Hormones
	Darolutamide (BAY-1841788) 是一种雄激素受体(AR) 拮抗剂，在体内试验中的IC50值为26 nM。
T0272	Nilutamide 尼鲁米特,RU23908	Androgen Receptor	Endocrinology/Hormones
	Nilutamide (RU23908) 是一种非甾体抗雄激素药物，有用于转移性前列腺癌的潜力。
T2108	Andarine S-4,GTx-007	Androgen Receptor	Endocrinology/Hormones
	Andarine (GTx-007) 是一种选择性的、具有口服活性的、非甾体受体雄激素受体(AR)调节剂 (SARM) 和部分激动剂，Ki=4 nM。它是一种具有较强活性的、具有组织选择性的 SARM。
T2556	Nandrolone decanoate 癸酸诺龙,19-Nortestosterone decanoate	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Nandrolone decanoate (19-Nortestosterone decanoate) 是一种合成代谢雄激素，通过涉及谷氨酸诱导的 N-甲基-D-天冬氨酸受体过度兴奋的机制诱导攻击性行为表征。
T0476	Spironolactone 安体舒通,螺内酯,SC9420,Abbolactone	Glucocorticoid Receptor; Androgen Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	Spironolactone (SC9420) 是一种可口服的醛固酮盐皮质激素受体拮抗剂，IC50值为 24 nM。它也是雄激素受体拮抗剂，促进足细胞自噬，IC50值为 77 nM。
T12146	N-Desmethyl-Apalutamide N-Desmethyl Apalutamide,N-去甲基阿帕鲁胺杂质	P450; Androgen Receptor	Endocrinology/Hormones; Metabolism
	N-Desmethyl-Apalutamide 是一种 Apalutamide 的活性代谢产物，主要由 CYP2C8 和 CYP3A4 介导形成。它是一种低活性的雄激素受体拮抗剂，其作用力是 Apalutamide 活性的三分之一。它是中等至强的CYP3A4和CYP2B6诱导剂，并具有优异的血浆蛋白结合浓度。
T4358	Vosilasarm Testolone,RAD140	Androgen Receptor	Endocrinology/Hormones
	Testolone 是一种有效的、非甾体的、具有口服活性的、选择性雄激素受体调节剂 (SARM)，Ki 为 7 nM。它对雄激素受体的选择性比其他类固醇激素核受体高。
T9179	CLP-3094 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE	Androgen Receptor	Endocrinology/Hormones
	CLP-3094 (2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE) 是一种雄激素受体 BF3(binding function 3) 抑制剂，是一种选择性GPR142拮抗剂。BF3-IN-1 抑制 AR 转录活性 (IC50:4 μM)。
T1167	Cyproterone acetate Androcur,醋酸环丙氯地孕酮,Cyproterone 17-O-acetate,醋酸环丙孕酮	Androgen Receptor	Endocrinology/Hormones
	Cyproterone acetate (Cyproterone 17-O-acetate) 是能够抗雄激素(IC50=7.1 nM) 和孕激素合成的类固醇。它与 progesteron 和糖皮质激素受体有亲和力。
T7440	p,p'-DDE p,p'-dichlorodiphenyldichloroethylene,4,4'-DDE,Dichlorodiphenyldichloroethylene,2，2-双（4-氯苯基）-1，1-二氯乙烯	Androgen Receptor; Drug Metabolite	Endocrinology/Hormones; Metabolism
	p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) 是持久性 DDT 的主要代谢物。4,4'-DDE 是一种有效的雄激素受体拮抗剂，IC50=5 μM，Ki=3.5 μM。
T20789	S-23 (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23	Androgen Receptor	Endocrinology/Hormones
	S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) 是口服选择性雄激素受体调节剂(Ki:1.7 nM)。它能够诱导 CV-1 细胞雄激素受体介导的转录激活，提高去势大鼠前列腺、精囊和肛提肌重量。
T2236	RU 58841 4-[3-(4-羟基丁基)-4,4-二甲基-2,5-二氧代-1-咪唑烷基]-2-(三氟甲基)苯腈,RU58841,PSK-3841,HMR-3841	Androgen Receptor	Endocrinology/Hormones
	RU 58841 (PSK-3841) 是一种雄激素受体拮抗剂，能够促进头发再生。
T19450	N-desmethyl Enzalutamide 4-[3-[4-氰基-3-(三氟甲基)苯基]-5,5-二甲基-4-氧代-2-硫代-1-咪唑烷基]-2-氟苯甲酰胺,N-desmethyl MDV 3100	Androgen Receptor	Endocrinology/Hormones
	N-desmethyl Enzalutamide (N-desmethyl MDV 3100) 是一种 Enzalutamide 的主要活性代谢物，具有与 Enzalutamide 相似的一级和二级药效功效，并在与 Enzalutamide 大致相同的血浆浓度下循环。
T3357	Clascoterone Cortexolone 17 alpha-propionate,17 alpha-propionate,21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮,CB-03-01,Cortexolone 17α-propionate	Androgen Receptor	Endocrinology/Hormones
	Clascoterone (CB-03-01) 是一种新型的局部和外周的雄性激素拮抗剂。
T1244	Celiprolol hydrochloride Selecor,Selectrol,盐酸塞利洛尔	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Celiprolol hydrochloride (Selectrol) 是一种选择性肾上腺素受体调节剂，是一种选择性的和具有口服活性的β1肾上腺素受体拮抗剂，具有部分β2激动剂活性，具有降压和抗心绞痛的作用。
T6509	Galeterone VN-124-1,TOK-001,VN/124-1,VN 124	P450; Androgen Receptor	Endocrinology/Hormones; Metabolism
	Galeterone (VN 124) 是CYP17抑制剂，能够多功能的抗雄激素，在去势抵抗性前列腺癌中，其IC50值为 47 nM。

化合物

Androgen receptor antagonist 1

Cat.No: T10320

Target: Others

Cat.No: T72985

Synonym: Androgen receptor-IN-2

Target: Others

Androgen receptor degrader-3

Cat.No: T79891

Target: Androgen Receptor

Androgen receptor antagonist 3

Cat.No: T60987

Target: Others

Androgen receptor degrader-2

Cat.No: T80647

Target: Androgen Receptor

Androgen receptor degrader-1

Cat.No: T80633

Target: Androgen Receptor

Androgen receptor antagonist 4

Cat.No: T60988

Target: Others

Androgen receptor-IN-5

Cat.No: T79024

Target: Androgen Receptor

Androgen receptor antagonist 9

Cat.No: T83119

Target: Androgen Receptor

Androgen receptor antagonist 5

Cat.No: T63324

Target: Others

Cat.No: T0380

Synonym: 比卡鲁胺,ICI-176334

Target: Androgen Receptor, Autophagy

Cat.No: T12928

Target: Androgen Receptor

Testosterone undecanoate

Cat.No: T9035

Target: Others, Androgen Receptor

Bavdegalutamide

Cat.No: T22263

Synonym: ARV-110

Target: Androgen Receptor

Cat.No: T9246

Target: Androgen Receptor

Cat.No: T6829

Synonym: EPI001,EPI 001

Target: Apoptosis, Androgen Receptor, PPAR

Cat.No: T14116

Target: Androgen Receptor

Cat.No: T12323

Target: Androgen Receptor

Cat.No: T13272

Target: Androgen Receptor

Cat.No: T26539

Synonym: AC262536,4-(3-内型-羟基-8-氮杂双环[3.2.1]辛烷-8-基)萘-1-甲腈

Target: Androgen Receptor

2-hydroxy Flutamide

Cat.No: T7690

Target: Androgen Receptor

Cat.No: T3618

Synonym: GSK2881078,GSK 2881078

Target: Androgen Receptor

Cat.No: T2339

Synonym: ARN-509

Target: Androgen Receptor, GABA Receptor

Cat.No: T20625

Synonym: 咪鲜胺,Sporgon,Prelude

Target: Estrogen Receptor/ERR, AhR, Androgen Receptor, Antifungal

JNJ-63576253 free base

Cat.No: T8933

Synonym: TRC253,JNJ-63576253

Target: Androgen Receptor

Cat.No: T39695

Target: Androgen Receptor, PROTACs

Enzalutamide carboxylic acid

Cat.No: T8217

Target: Androgen Receptor, Drug Metabolite

Cat.No: T21740

Target: Androgen Receptor

Cat.No: T5100

Synonym: DJ-V159

Target: GPR, Androgen Receptor

Cat.No: T0489

Synonym: SCH 13521,氟他胺

Target: Androgen Receptor

Cat.No: T6400

Target: Androgen Receptor

Cat.No: T6889

Target: Apoptosis, Epigenetic Reader Domain, Androgen Receptor

Cat.No: T6002

Synonym: MDV3100,恩杂鲁胺

Target: Androgen Receptor, Autophagy

Cat.No: T13273

Target: Androgen Receptor

Cat.No: T6915

Synonym: ODM-201,BAY-1841788

Target: Androgen Receptor

Cat.No: T0272

Synonym: 尼鲁米特,RU23908

Target: Androgen Receptor

Cat.No: T2108

Synonym: S-4,GTx-007

Target: Androgen Receptor

Nandrolone decanoate

Cat.No: T2556

Synonym: 癸酸诺龙,19-Nortestosterone decanoate

Target: Others, HIV Protease

Cat.No: T0476

Synonym: 安体舒通,螺内酯,SC9420,Abbolactone

Target: Glucocorticoid Receptor, Androgen Receptor, Autophagy

N-Desmethyl-Apalutamide

Cat.No: T12146

Synonym: N-Desmethyl Apalutamide,N-去甲基阿帕鲁胺杂质

Target: P450, Androgen Receptor

Cat.No: T4358

Synonym: Testolone,RAD140

Target: Androgen Receptor

Cat.No: T9179

Synonym: 2-([2-(4-CHLOROPHENOXY)ETHYL]THIO)-1H-BE

Target: Androgen Receptor

Cyproterone acetate

Cat.No: T1167

Synonym: Androcur,醋酸环丙氯地孕酮,Cyproterone 17-O-acetate,醋酸环丙孕酮

Target: Androgen Receptor

Cat.No: T7440

Synonym: p,p'-dichlorodiphenyldichloroethylene,4,4'-DDE,Dichlorodiphenyldichloroethylene,2，2-双（4-氯苯基）-1，1-二氯乙烯

Target: Androgen Receptor, Drug Metabolite

Cat.No: T20789

Synonym: (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23

Target: Androgen Receptor

Cat.No: T2236

Synonym: 4-[3-(4-羟基丁基)-4,4-二甲基-2,5-二氧代-1-咪唑烷基]-2-(三氟甲基)苯腈,RU58841,PSK-3841,HMR-3841

Target: Androgen Receptor

N-desmethyl Enzalutamide

Cat.No: T19450

Synonym: 4-[3-[4-氰基-3-(三氟甲基)苯基]-5,5-二甲基-4-氧代-2-硫代-1-咪唑烷基]-2-氟苯甲酰胺,N-desmethyl MDV 3100

Target: Androgen Receptor

Cat.No: T3357

Synonym: Cortexolone 17 alpha-propionate,17 alpha-propionate,21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮,CB-03-01,Cortexolone 17α-propionate

Target: Androgen Receptor

Celiprolol hydrochloride

Cat.No: T1244

Synonym: Selecor,Selectrol,盐酸塞利洛尔

Target: Adrenergic Receptor

Cat.No: T6509

Synonym: VN-124-1,TOK-001,VN/124-1,VN 124

Target: P450, Androgen Receptor

Cat. No.	Product Name	Target	Signaling Pathways
T14008	2,2,5,7,8-Pentamethyl-6-Chromanol PMC	Androgen Receptor	Endocrinology/Hormones
	2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) 是维生素 E (α-tocopherol) 的抗氧化部分，能够有效的调节雄激素受体 (androgen receptor) 信号，及抗前列腺癌细胞系的抗癌活性。
TQ0209	Ailanthone 臭椿酮,Δ13-Dehydrochaparrinone	Androgen Receptor	Endocrinology/Hormones
	Ailanthone (Δ13-Dehydrochaparrinone) 是一种有效的雄激素受体 (androgen receptor (AR)) 抑制剂，能够抑制完整雄激素受体(IC50:69 nM)、持续活跃剪切变体(IC50:309 nM)。
T3393	Triptophenolide Hypolide,(+)-Triptophenolide,鼠尾草酸,雷酚内酯	Androgen Receptor	Endocrinology/Hormones
	Triptophenolide (Hypolide) 是一种无色晶体，从雷公藤的乙酸乙酯萃取部位分离得到。
T8709	Nandrolone phenylpropionate Nandrolone phenpropionate,苯丙酸诺龙	Androgen Receptor	Endocrinology/Hormones
	Nandrolone phenylpropionate (Nandrolone phenpropionate) 是一种合成代谢类固醇，是一种 19-nortestosterone 的衍生物。它能够促进蛋白质合成，用于缓解组织分解代谢，可以用于骨质疏松症和特纳综合征的研究。
TQ0214	Dimethylcurcumin ASC-J9,二甲基姜黄素,GO-Y025	Androgen Receptor	Endocrinology/Hormones
	Dimethylcurcumin (ASC-J9) 是雄激素受体降解增强剂，能够有效抑制耐药性前列腺癌细胞增殖和侵袭。
TC0025	Testosterone acetate NSC523836,NSC-523836,NSC 523836,醋酸睾酮	Others	Others
	Testosterone acetate (NSC-523836) 是一种 Testosterone 前药，是一种天然存在的雄激素睾酮酯。它可用于阳痿、虚弱、疲劳和性腺机能减退的研究。
T2991	3,3'-Diindolylmethane HB 236,二吲哚甲烷,DIM,Arundine	Androgen Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	3,3'-Diindolylmethane (DIM) 是一种小分子雄激素受体拮抗剂。
T2895	Lupeol Fagarasterol,羽扇豆醇,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol	Apoptosis; Androgen Receptor; Akt	Apoptosis; Cytoskeletal Signaling; Endocrinology/Hormones; PI3K/Akt/mTOR signaling
	Lupeol (Monogynol B) 是一个活跃的五环三萜，具有抗氧化剂、抗肿瘤和抗炎活性。它是一种雄激素受体抑制剂，可研究癌症，特别是雄激素依赖表型和去势抵抗表型的前列腺癌。
T2207	Adrenosterone 肾上腺甾酮,11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G	Androgen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Adrenosterone (11-ketoandrostenedione) 是一种人内源性代谢物，由肾上腺皮质产生。Adrenosterone 是一种竞争性羟基类固醇脱氢酶 1 抑制剂。它是一种的类固醇激素，具有较弱的雄激素特性。它是一种膳食补充剂，能够减少脂肪并提高肌肉质量。它能够抑制人类癌细胞的转移进展。
T1261	Medroxyprogesterone Acetate Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,醋酸甲羟孕酮,Farlutin,安宫黄体酮,Medroxyprogesterone (acetate)	Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; Androgen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism; Others
	Medroxyprogesterone Acetate (Farlutin) 是广泛使用的合成类固醇，与雄激素，孕酮及糖皮质激素受体均有作用。
T0856	Dehydroisoandrosterone 3-acetate Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,醋酸去氢表雄酮,androstenolone acetate	Androgen Receptor	Endocrinology/Hormones
	Dehydroisoandrosterone 3-acetate (Prasterone acetate) 是一种雄性激素/雌性激素的前体物质，是一种由肾上腺皮质产生的主要 C19 类固醇，能够调节脊椎动物的攻击性行为。
T7873	Iberverin	Others	Others
	Iberverin 是一种天然产品。它诱导 II 期酶活性并降低前列腺癌细胞中雄激素受体的表达。
TN5031	Sitostenone 豆甾-4-烯-3-酮	Others	Others
	Sitostenone 具有抗氧化活性。 Stigmasta-4-en-3-one(Sitostenone)可用于治疗雄激素依赖性疾病，尤其是治疗良性前列腺增生。
T13518	5α-Pregnane-3β,6α-diol-20-one	Others	Others
	5α-Pregnane-3β,6α-diol-20-one 是促进有丝分裂的 progesterone 代谢物，可于血清不足时雄性激素反应的前列腺素癌细胞中产生。
TN1677	Gartanin 1,3,5,8-四羟基-2,4-双(3-甲基-2-丁烯基)-9H-氧杂蒽-9-酮,藤黄苷	BCL; Caspase; JNK	Apoptosis; MAPK; Proteases/Proteasome
	Gartanin 是山竹果中的一种天然黄酮，具有抗氧化、抗真菌、抗炎、神经保护和抗肿瘤活性。它能够诱导人脑胶质瘤细胞的细胞周期阻滞和自噬，抑制其迁移。
TN1805	Isosilybin B	Apoptosis; Androgen Receptor	Apoptosis; Endocrinology/Hormones
	Isosilybin B 是一种从水飞蓟中提取的黄酮木脂素，具有抗前列腺癌 (PCA) 活性，对癌细胞增殖有抑制作用，促使 G1 期阻滞和凋亡。Isosilybin B 诱导雄激素受体降解。
T5574	Guggulsterone Guggulsterone E&Z,香胶甾酮	Apoptosis; FXR; Akt; Caspase; JNK; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Guggulsterone (Guggulsterone E&Z) E&Z 是来自Commiphora wightii 树中树胶脂的植物甾醇。它通过下调抗细胞凋亡基因产物，调节细胞周期蛋白，激活caspases，JNK，抑制Akt，抑制多种肿瘤细胞的生长并诱导细胞凋亡。它是法尼醇 X 受体拮抗剂，可降低 CDCA 诱导的 FXR 活化。
T3390	Obacunone	Apoptosis; Aromatase; p38 MAPK	Apoptosis; Endocrinology/Hormones; MAPK
	Obacunone 是从沼泽白葡萄柚种子中分离得到的，通过诱导凋亡发挥抗癌作用。它在雄激素依赖性人前列腺 Y 细胞中具有细胞毒性。它对鼠伤寒沙门氏菌具有抗毒作用，可作为开发鼠伤寒沙门氏菌抗毒策略的先导化合物。
T3851	Vicenin 2 Vicenin -2,维采宁 2,新西兰牡荆苷	RAAS	Endocrinology/Hormones
	Vicenin 2 来源于广金钱草 (Desmodium styracifolium) 的地上部分。Vicenin 2 是一种血管紧张素转换酶 (ACE) 抑制剂，IC50=43.83 μM。
T4000	(±)-Equol Equol,(±)-雌马酚,(R,S)-Equol	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Drug Metabolite	Endocrinology/Hormones; Metabolism
	(±)-Equol ((R,S)-Equol) 是 equol 的外消旋体。它对 ERα 和 ERβ 的 EC50s of 分别为 200 和 74 nM。Equol 是大豆异黄酮黄豆苷和大豆黄素的代谢产物。
TN1150	Procyanidin B3 原花青素B3,原花青素 B3	Histone Acetyltransferase	Chromatin/Epigenetic
	Procyanidin B3 是从葡萄中提取的一种黄酮类天然产物，是组蛋白乙酰转移酶特异性抑制剂，可与 p300的其他位点而非活性位点结合，选择性抑制 p300 介导的 androgen 受体乙酰化。
T6491	(-)-(S)-Equol (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	(-)-(S)-Equol (4',7-Dihydroxyisoflavan) 是雌激素受体β的高亲和力配体。
TN1308	6-Hydroxyflavanone	Others; Lipoxygenase; COX; GABA Receptor	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others
	6-Hydroxyflavanone 是从菖蒲叶中提取分离，通过靶向环氧合酶-2（COX-2），5-脂氧合酶（5-LOX）以及阿片类药物和 GABA-A 受体从而具有抗炎和抗神经性疼痛活性。6-Hydroxyflavanone 在链脲佐菌素诱导的糖尿病神经病变模型中具有抗伤害感受特性。
TN3416	Angelol M	Others	Others
	Angelol M shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.
TN6638	(E)-6-O-(p-coumaroyl)scandoside methyl ester
	(E)-6-O-(p-coumaroyl)scandoside methyl ester shows moderate anti-proliferation effect on PC3 human androgen-independent prostate cancer cells.
T11834	Leelamine hydrochloride	Others	Others
	Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabinoid receptor type 1 (CB1) agonist and suppresses SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells, irrespective of androgen receptor status.
TN6337	Lupichromone 鲁冰花,5,7-Dihydroxy-6,8-diprenylchromone,5,7-二羟基-6,8-二异戊烯基色原酮
	Eriosemation significant androgen receptor (AR) inhibition activity, suggests that it could be a promising candidate for further evaluation for prostate cancer prevention or management.
TN5878	7,2',4'-Trihydroxy-5-methoxy-3-phenylcoumarin
	7,2',4'-Trihydroxy-5-methoxy-3-arylcoumarin shows activity in inhibiting prostate specific antigen (PSA) secreted from androgen dependent prostate cancer cell line, LNCaP cells.
T75702	Galloylalbiflorin	Others	Others
	Galloylalbiflorin (6′-O-Galloylalbiflorin) 为芍药根部提取的雄性激素受体 (AR) 拮抗剂，具IC50值为53.3 μM，展现抗雄激素活性。
TN4774	Physalin A	ERK; BCL; p38 MAPK; NF-κB; Androgen Receptor; ROS; JAK; JNK; STAT; p53; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; JAK/STAT signaling; MAPK; NF-κB; Stem Cells
	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor ex
T73780	11β-Hydroxyandrosterone	Others	Others
	11β-Hydroxyandrosterone 是 11β-hydroxyandrostenedione 的 11-氧化雄激素代谢物。
TN1061	Ganoderol B	Androgen Receptor	Endocrinology/Hormones
	Ganoderol B is a potent β ±-glucosidase and angiotensin-converting enzyme inhibitor, with an IC(50) of β ±-glucosidase is 119.8 uM. It may be useful in prostate cancer and benign prostatic hyperplasia (BPH) therapy through suppressing the function of andr

天然产物

2,2,5,7,8-Pentamethyl-6-Chromanol

Cat.No: T14008

Synonym: PMC

Target: Androgen Receptor

Cat.No: TQ0209

Synonym: 臭椿酮,Δ13-Dehydrochaparrinone

Target: Androgen Receptor

Triptophenolide

Cat.No: T3393

Synonym: Hypolide,(+)-Triptophenolide,鼠尾草酸,雷酚内酯

Target: Androgen Receptor

Nandrolone phenylpropionate

Cat.No: T8709

Synonym: Nandrolone phenpropionate,苯丙酸诺龙

Target: Androgen Receptor

Dimethylcurcumin

Cat.No: TQ0214

Synonym: ASC-J9,二甲基姜黄素,GO-Y025

Target: Androgen Receptor

Testosterone acetate

Cat.No: TC0025

Synonym: NSC523836,NSC-523836,NSC 523836,醋酸睾酮

Target: Others

3,3'-Diindolylmethane

Cat.No: T2991

Synonym: HB 236,二吲哚甲烷,DIM,Arundine

Target: Androgen Receptor, Autophagy

Cat.No: T2895

Synonym: Fagarasterol,羽扇豆醇,Monogynol B,Clerodol,(3β,13ξ)-Lup-20(29)-en-3-ol,Farganasterol

Target: Apoptosis, Androgen Receptor, Akt

Cat.No: T2207

Synonym: 肾上腺甾酮,11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G

Target: Androgen Receptor, Endogenous Metabolite

Medroxyprogesterone Acetate

Cat.No: T1261

Synonym: Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,醋酸甲羟孕酮,Farlutin,安宫黄体酮,Medroxyprogesterone (acetate)

Target: Glucocorticoid Receptor, Estrogen/progestogen Receptor, Progesterone Receptor, Androgen Receptor, Endogenous Metabolite

Dehydroisoandrosterone 3-acetate

Cat.No: T0856

Synonym: Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,醋酸去氢表雄酮,androstenolone acetate

Target: Androgen Receptor

Cat.No: T7873

Target: Others

Cat.No: TN5031

Synonym: 豆甾-4-烯-3-酮

Target: Others

5α-Pregnane-3β,6α-diol-20-one

Cat.No: T13518

Target: Others

Cat.No: TN1677

Synonym: 1,3,5,8-四羟基-2,4-双(3-甲基-2-丁烯基)-9H-氧杂蒽-9-酮,藤黄苷

Target: BCL, Caspase, JNK

Cat.No: TN1805

Target: Apoptosis, Androgen Receptor

Cat.No: T5574

Synonym: Guggulsterone E&Z,香胶甾酮

Target: Apoptosis, FXR, Akt, Caspase, JNK, Autophagy

Cat.No: T3390

Target: Apoptosis, Aromatase, p38 MAPK

Cat.No: T3851

Synonym: Vicenin -2,维采宁 2,新西兰牡荆苷

Target: RAAS

Cat.No: T4000

Synonym: Equol,(±)-雌马酚,(R,S)-Equol

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Drug Metabolite

Cat.No: TN1150

Synonym: 原花青素B3,原花青素 B3

Target: Histone Acetyltransferase

Cat.No: T6491

Synonym: (−)-Equol,Equol,4',7-Dihydroxyisoflavan,4',7-Isoflavandiol,雌马酚

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

6-Hydroxyflavanone

Cat.No: TN1308

Target: Others, Lipoxygenase, COX, GABA Receptor

Cat.No: TN3416

Target: Others

(E)-6-O-(p-coumaroyl)scandoside methyl ester

Cat.No: TN6638

Leelamine hydrochloride

Cat.No: T11834

Target: Others

Cat.No: TN6337

Synonym: 鲁冰花,5,7-Dihydroxy-6,8-diprenylchromone,5,7-二羟基-6,8-二异戊烯基色原酮

7,2',4'-Trihydroxy-5-methoxy-3-phenylcoumarin

Cat.No: TN5878

Galloylalbiflorin

Cat.No: T75702

Target: Others

Cat.No: TN4774

Target: ERK, BCL, p38 MAPK, NF-κB, Androgen Receptor, ROS, JAK, JNK, STAT, p53, Autophagy

11β-Hydroxyandrosterone

Cat.No: T73780

Target: Others

Cat.No: TN1061

Target: Androgen Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-06986	FGF-8b Protein, Human, Recombinant NEWENTRY,fibroblast growth factor 8 (androgen-induc...	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac...
TMPY-00005	FGF-8a Protein, Human, Recombinant fibroblast growth factor 8 (androgen-induced),FGF-8...	Human	E. coli
	In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment in postnatal mammals. Retinoic acid (RA) directly represses Fgf8 through a RARE-mediated mechanism that promotes repressive chromatin, thus providing valuable insight into the mechanism of RA-FGF antagonism during progenitor cell differentiation. Fgf8 encodes a key signaling fac...
TMPH-00932	Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) Nuclear receptor subfamily 3 group C member 4,AR,NR3C4,Dihyd...	Human	E. coli
	Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPY-00133	PARM-1 Protein, Human, Recombinant (His) PARM-1,Cipar1,WSC4,prostate androgen-regulated muci...	Human	HEK293 Cells
	PARM-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.7 kDa and the accession number is AAH13294.1.
TMPY-03807	SMR3B Protein, Human, Recombinant (His) P-B,PBII,PROL3,SMR3B,submaxillary gland androgen re...	Human	HEK293 Cells
	SMR3B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 7.3 kDa and the accession number is P02814.
TMPY-01116	SMR3B Protein, Human, Recombinant (mFc) SMR3B,submaxillary gland androgen regulated protein...	Human	HEK293 Cells
	SMR3B Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 32.2 kDa and the accession number is P02814.
TMPH-00933	ADTRP Protein, Human, Recombinant (His & Myc) Fatty acid esters of hydroxy fatty acids hydrolase ADTRP,FAH...	Human	E. coli
	ADTRP Protein, Human, Recombinant (His & Myc) is expressed in in vitro E. coli expression system.
TMPH-01679	WDR77 Protein, Human, Recombinant (His & SUMO) Methylosome protein WDR77,Methylosome protein 50,Androge...	Human	E. coli
	WDR77 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 49.6 kDa and the accession number is Q9BQA1.
TMPH-01419	RAN Protein, Human, Recombinant (GST) Ras-like protein TC4,GTPase Ran,RAN,GTP-binding nuclear prot...	Human	E. coli
	RAN Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 51.3 kDa and the accession number is P62826.
TMPH-02284	USP26 Protein, Human, Recombinant (His) USP26,Deubiquitinating enzyme 26,Ubiquitin thioesterase 26,U...	Human	E. coli
	Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway.
TMPY-00611	UBE2B Protein, Mouse, Recombinant mHR6B,ubiquitin-conjugating enzyme E2B,Rad6b,HR6B,E2-14k,261...	Mouse	E. coli
	The ubiquitin-conjugating enzyme E2B (Ube2b) is a critical target gene of androgen receptor (AR), mediating the function of AR in spermatogenesis by promoting H2A ubiquitylation. Moreover, UBE2B plays an important role in muscle protein homeostasis during catabolic conditions.
TMPJ-00207	AKR1C2 Protein, Human, Recombinant 3-Alpha-HSD3,Chlordecone Reductase Homolog HAKRD,2-Diol Dehy...	Human	E. coli
	Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation of the most potent androgen 5-α-Dihydrotestosterone (5-α-DHT) to 5-α-Androstane-3-α, 17-β-diol (3-α-diol).
TMPH-02139	CYP17A1 Protein, Human, Recombinant (GST) Cytochrome P450 17A1,CYPXVII,CYP17A1,CYP17,S17AH,Cytochrome ...	Human	E. coli
	A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol (Probable). Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, follow...
TMPK-01387	EPhA3 Protein, Canine, Recombinant (His) HEK4,TYRO4,ETK1,EPHA3,HEK,ETK,EK4	Canine	HEK293 Cells
	Erythropoietin‑producing hepatocellular carcinoma cell surface type‑A receptor 3 (EPHA3) has been found to promote the proliferation and survival of prostate cancer (PCa) cell lines and prostate tumor development in nude mice. The interaction of AR and SP1 contributes to regulate EPHA3 expression, and the SP1 binding sites (‑295~‑261) in the EPHA3 core promoter region is crucial to the regulation of EPHA3 expression in response to androgen hormone stimuli.
TMPK-00850	MFGE8 Protein, Mouse, Recombinant (His) MFG-E8,Lactadherin,SPAG10,BA46,MFG1,SED1,EDIL1,MP47,MFGM,HsT...	Mouse	HEK293 Cells
	MFGE8 (Milk Fat Globule EGF And Factor V/VIII Domain Containing) is a Protein Coding gene. Diseases associated with MFGE8 include Anal Paget's Disease and Topographical Agnosia. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Extracellular vesicle-mediated signaling in recipient cells. This protein plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing.
TMPH-01303	HSD17B11 Protein, Human, Recombinant (His & Myc) Estradiol 17-beta-dehydrogenase 11,HSD17B11,Retinal short-ch...	Human	E. coli
	Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma. HSD17B11 Prot...
TMPY-03056	LSD1 Protein, Human, Recombinant (His & GST) BHC110,LSD1,KDM1,AOF2,lysine (K)-specific demethylase 1A	Human	Baculovirus Insect Cells
	LSD1 belongs to the flavin monoamine oxidase family. It contains 1 SWIRM domain and is a component of an RCOR/GFI/LSD1/HDAC complex. LSD1 interacts directly with GFI1 and GFI1B. LSD1 specifically removes histone H3K4me2 to H3K4me1 or H3K4me0 through a FAD-dependent oxidative reaction. When forming a complex with an androgen receptor (and possibly other nuclear hormone receptors), LSD1 changes its substrates to H3K9me2. Thus LSD1 is considered to act as a coactivator or a corepressor. It may play...
TMPY-04408	CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST) calcium/calmodulin-dependent protein kinase II beta,CAM2,CAM...	Human	Baculovirus Insect Cells
	Calcium/calmodulin-dependent protein kinase II beta (CAMK2B) is a member of the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. CaMKII is an important player in prostate cancer cells ability to escape apoptosis under androgen ablation and facilitate the progression of prostate cancer cells to an androgen independent state. As a multifunctional protein kinase, the loss of activity may play a critical role in initiating the changes leading to...
TMPY-02844	EBP1 Protein, Human, Recombinant (His) proliferation-associated 2G4,EBP1,p38-2G4,HG4-1	Human	E. coli
	EBP1, also known as PA2G4, is an RNA-binding protein that belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein is a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its int...
TMPY-01190	INHBB Protein, Human, Recombinant (His) inhibin beta B,INHBB,Inhibin β B Protein,MGC157939,inhibin β...	Human	HEK293 Cells
	Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two ß subunits, ßA ßA (activin A), ßB ßB (activin B), or ßA ßB (activin AB). Inhibin is composed of an alpha and one of two ß subunits, ßA (inhibin A) or ßB (inhibin B). Activins are produced in...
TMPY-04484	ACK1 Protein, Human, Recombinant (GST) ACK-1,ACK1,p21cdc42Hs,ACK,tyrosine kinase, non-receptor, 2	Human	Baculovirus Insect Cells
	ACK1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non-receptor tyrosine kinase that is expressed in diverse cell types. This downstream effector of CDC42 mediates CDC42-dependent cell migration via phosphorylation of BCAR1. The ACK1 protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. ACK1 integrates signals from plethora of liga...
TMPY-02043	PARK7/DJ-1 Protein, Human, Recombinant (His) DJ1,HEL-S-67p,DJ-1,parkinson protein 7	Human	E. coli
	Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress...
TMPY-01846	Activin A Protein, Mouse, Recombinant (His) inhibin, β A,inhibin, beta A	Mouse	HEK293 Cells
	Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two β subunits, βA βA (activin A), βB βB (activin B), or βA βB (activin AB). Inhibin is composed of an alpha and one of two β subunits, βA (inhibin A) or βB (inhibin B). Activins are produced in...
TMPH-02236	TMPRSS2 Protein, Human, Recombinant (E. coli, His) Transmembrane protease serine 2,TMPRSS2,Serine protease 10	Human	E. coli
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia....
TMPH-02237	TMPRSS2 Protein, Human, Recombinant (His & Myc) Serine protease 10,Transmembrane protease serine 2,TMPRSS2	Human	HEK293 Cells
	Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia....

重组蛋白

FGF-8b Protein, Human, Recombinant

Cat.No: TMPY-06986

Species: Human

Expression System: E. coli

FGF-8a Protein, Human, Recombinant

Cat.No: TMPY-00005

Species: Human

Expression System: E. coli

Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00932

Species: Human

Expression System: E. coli

PARM-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00133

Species: Human

Expression System: HEK293 Cells

SMR3B Protein, Human, Recombinant (His)

Cat.No: TMPY-03807

Species: Human

Expression System: HEK293 Cells

SMR3B Protein, Human, Recombinant (mFc)

Cat.No: TMPY-01116

Species: Human

Expression System: HEK293 Cells

ADTRP Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00933

Species: Human

Expression System: E. coli

WDR77 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01679

Species: Human

Expression System: E. coli

RAN Protein, Human, Recombinant (GST)

Cat.No: TMPH-01419

Species: Human

Expression System: E. coli

USP26 Protein, Human, Recombinant (His)

Cat.No: TMPH-02284

Species: Human

Expression System: E. coli

UBE2B Protein, Mouse, Recombinant

Cat.No: TMPY-00611

Species: Mouse

Expression System: E. coli

AKR1C2 Protein, Human, Recombinant

Cat.No: TMPJ-00207

Species: Human

Expression System: E. coli

CYP17A1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02139

Species: Human

Expression System: E. coli

EPhA3 Protein, Canine, Recombinant (His)

Cat.No: TMPK-01387

Species: Canine

Expression System: HEK293 Cells

MFGE8 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00850

Species: Mouse

Expression System: HEK293 Cells

HSD17B11 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01303

Species: Human

Expression System: E. coli

LSD1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03056

Species: Human

Expression System: Baculovirus Insect Cells

CAMKII beta/CAMK2B Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04408

Species: Human

Expression System: Baculovirus Insect Cells

EBP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02844

Species: Human

Expression System: E. coli

INHBB Protein, Human, Recombinant (His)

Cat.No: TMPY-01190

Species: Human

Expression System: HEK293 Cells

ACK1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04484

Species: Human

Expression System: Baculovirus Insect Cells

PARK7/DJ-1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02043

Species: Human

Expression System: E. coli

Activin A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01846

Species: Mouse

Expression System: HEK293 Cells

TMPRSS2 Protein, Human, Recombinant (E. coli, His)

Cat.No: TMPH-02236

Species: Human

Expression System: E. coli

TMPRSS2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02237

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T19416	Medroxyprogesterone acetate D3 MPA D3,Medroxyprogesterone 17-acetate D3	Others	Others
	Medroxyprogesterone acetate D3 is deuterium labeled Medroxyprogesterone acetate. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.
T11208	Enzalutamide-d3 MDV3100 D3	Others	Others
	Enzalutamide D3 is a deuterium labeled Enzalutamide . Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.
TMIH-0094	Apalutamide-d7
	Apalutamide-d7 是 Apalutamide 的氘代化合物。Apalutamide 的 CAS 号为 956104-40-8。Apalutamide 是一种有效、竞争性的雄激素受体 (AR) 拮抗剂(IC50:16 nM)。
TMIH-0092	Apalutamide-13C-d3
	Apalutamide-13C-d3 是 Apalutamide 的 13C 和氘代化合物。Apalutamide 的 CAS 号为 956104-40-8。Apalutamide 是一种有效、竞争性的雄激素受体 (AR) 拮抗剂(IC50:16 nM)。
TMIH-0218	Enzalutamide-d6 Carboxylic Acid
	Enzalutamide-d6 Carboxylic Acid 是 Enzalutamide Carboxylic Acid 的氘代化合物。Enzalutamide Carboxylic Acid 的 CAS 号为 1242137-15-0。Enzalutamide carboxylic acid 是 Enzalutamide 非活性代谢物。Enzalutamide 是雄激素受体 (AR) 拮抗剂。
TMIJ-0248	Stanolone-d4
	Stanolone-d4 是 Stanolone 的氘代化合物。Stanolone 的 CAS 号为 521-18-6。Dihydrotestosterone(DHT) 是睾酮的强效雄激素代谢物。它是雄激素受体的激动剂。
TMIJ-0057	5α-Dihydrotestosterone-d4
	5α-Dihydrotestosterone-d4 是 5α-Dihydrotestosterone 的氘代化合物。5α-Dihydrotestosterone 的 CAS 号为 521-18-6。Dihydrotestosterone(DHT) 是睾酮的强效雄激素代谢物。它是雄激素受体的激动剂。
T69758	Flutamide-d7
	Flutamide-d7 is intended for use as an internal standard for the quantification of flutamide by GC- or LC-MS. Flutamide is an androgen receptor antagonist and prodrug form of 2-hydroxy flutamide. Flutamide is converted to 2-hydroxy flutamide by the cytochrome P450 (CYP) isoform CYP1A2 in human liver microsomes. It is cytotoxic to PC3 and LNCaP prostate cancer cells with IC50 values of 98.8 and 81.8 µM, respectively. Flutamide (50 mg/kg per day) reduces tumor growth in a PC-82 mouse xenograft mo...
TMIH-0372	N-desmethyl Apalutamide-d4
	N-desmethyl Apalutamide-d4 是 N-desmethyl Apalutamide 的氘代化合物。N-desmethyl Apalutamide 的 CAS 号为 1332391-11-3。N-Desmethyl Apalutamide 是一种 Apalutamide 的活性代谢产物，主要由 CYP2C8 和 CYP3A4 介导形成。它是一种低活性的雄激素受体拮抗剂，其作用力是 Apalutamide 活性的三分之一。它是中等至强的CYP3A4和CYP2B6诱导剂，并具有优异的血浆蛋白结合浓度。
TMIH-0235	Finerenone-d5
	Finerenone-d5 是 Finerenone 的氘代化合物。Finerenone 的 CAS 号为 1050477-31-0。Finerenone 是一种选择性、具有口服活性的、非甾体类盐皮质激素受体拮抗剂 (IC50=18 nM)。与糖皮质激素受体、雄激素受体和孕酮受体相比，它表现出良好的选择性 (>500-fold)。它在心肾疾病研究中具有潜在的应用前景，如 2 型糖尿病和慢性肾脏疾病。
T71142	Tebuconazole-d9
	Tebuconazole-d9 is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi. It inhibits 14α-demethylase isolated from U. maydis and S. bicolor with IC50 values of 0.05 and 0.16 nM, respectively. It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20 = 2.89 µM) and is cytotoxic (EC20 = 38.9 µM) in an MDA-kb2 assay. Tebuconazole (50 and 100 mg/kg per...

同位素标记化合物

Medroxyprogesterone acetate D3

Cat.No: T19416

Synonym: MPA D3,Medroxyprogesterone 17-acetate D3

Target: Others

Enzalutamide-d3

Cat.No: T11208

Synonym: MDV3100 D3

Target: Others

Cat.No: TMIH-0094

Apalutamide-13C-d3

Cat.No: TMIH-0092

Enzalutamide-d6 Carboxylic Acid

Cat.No: TMIH-0218

Cat.No: TMIJ-0248

5α-Dihydrotestosterone-d4

Cat.No: TMIJ-0057

Cat.No: T69758

N-desmethyl Apalutamide-d4

Cat.No: TMIH-0372

Cat.No: TMIH-0235

Tebuconazole-d9

Cat.No: T71142

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