CSRM617

Name: CSRM617
Brand: TargetMol
SKU: T10896
Price: 127 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T10896Cas号 787504-88-5

CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.

CSRM617

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产品编号 T10896Cas号 787504-88-5

规格	价格	库存
25 mg	¥ 10,600	1-2周
50 mg	¥ 13,800	1-2周
100 mg	¥ 17,500	1-2周

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产品介绍

生物活性

产品描述	CSRM617 is a selective small molecule inhibitor of the transcription factor ONECUT2 (OC2, the main regulator of androgen receptor). The Kd in SPR analysis is 7.43 uM, which can directly bind to the OC2-HOX domain. CSRM617 induces apoptosis by cleaving the presence of Caspase-3 and PARP. CSRM617 is well tolerated in a mouse model of prostate cancer.
体外活性	CSRM617 (0.01-100 μM; 48 hours) inhibits cell growth in several PC cell lines: PC-3, 22RV1, LNCaP, C4-2 cells. CSRM617 (10-20 μM; 48 hours) induces 22Rv1 cell apoptosis, leading to concentration-dependent cell death . CSRM617 (20 μM; 72 hours) induced 22Rv1 cell apoptosis by cleaving the presence of Caspase-3 and PARP.