589
39
6
72
28
Cat. No. | Product Name | ||
---|---|---|---|
L2620 | 神经退行性疾病化合物库 | 2154 compounds | |
2154 种与神经退行性疾病相关的化合物,可用于高通量和高内涵筛选; | |||
L9830 | 抗帕金森病化合物库 | 857 compounds | |
857 种帕金森病相关的化合物集合,可用于高通量和高内涵筛选; | |||
L9840 | 抗阿尔茨海默症化合物库 | 986 compounds | |
986 种阿尔茨海默症相关的化合物集合,可用于高通量和高内涵筛选; | |||
L2510 | 脂代谢化合物库 | 492 compounds | |
492 个脂代谢相关的化合物集合,可用于高通量和高内涵筛选; | |||
L2550 | 谷氨酰胺代谢化合物库 | 565 compounds | |
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选; | |||
L2170 | 肿瘤免疫治疗小分子化合物库 | 449 compounds | |
449 种靶向肿瘤免疫治疗靶点的小分子,可用于高通量和高内涵筛选,是研究肿瘤免疫治疗的有力工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5051 |
Isopropamide Iodide
|
AChR | Neuroscience |
Isopropamide iodide 是长效季铵盐抗胆碱能药物。它用于研究消化性溃疡和其他胃肠道疾病,尤其是胃酸过多和运动过度。 | |||
T0202 |
Sulbentine
Dibenzthione,舒苯汀 |
Antifungal | Microbiology/Virology |
Sulbentine (Dibenzthione) 是一种具有抑菌和杀真菌活性的唑类抗真菌试剂,可作为局部抗菌试剂。 | |||
T4985 |
Neticonazole Hydrochloride
|
Antifungal | Microbiology/Virology |
Neticonazole hydrochloride 是一种咪唑衍生物,具有抗感染和抗癌作用。它也是一种长效抗真菌剂。 | |||
T19862 |
Voxilaprevir
维昔普维,伏西瑞韦 |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Voxilaprevir 是丙型肝炎病毒非结构蛋白 3/4A 蛋白酶的抑制剂,具有抗病毒活性。它抑制基因型 1b 和 3a 野生型 NS3 蛋白酶的 Ki 值分别为 0.038 nM 和 0.066 nM。 | |||
T0388 |
Cilnidipine
FRC-8653,西尼地平 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Cilnidipine (FRC-8653) 是二氢吡啶类Ca2+通道阻断剂,可作用于 L 和 N 型 Ca2+通道,具有抗高血压活性。 | |||
T1674 |
Nateglinide
那格列奈,A4166,Senaglinide |
Potassium Channel; Proteasome; PPAR | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome; Ubiquitination |
Nateglinide (Senaglinide) 是 D-苯丙氨酸的一种衍生物,是口服有效的、短效促胰岛素释放化合物,也是 DPP IV 抑制剂。 Nateglinide 抑制胰岛 β 细胞中 ATP 敏感的 K+通道。Nateglinide 在 2 型糖尿病中具有研究价值。 | |||
T7943 |
Fluphenazine decanoate
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂,是一种长效吩噻嗪抗精神病药,用于精神分裂症的研究。 | |||
T3716 |
Rolapitant
罗拉吡坦,SCH619734,罗拉匹坦 |
Neurokinin receptor | GPCR/G Protein; Neuroscience |
Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂,Ki 值为0.66 nM。 | |||
T6504 |
Flupirtine maleate
Katadolon maleate,氟吡啶马来酸,马来酸氟吡汀 |
Potassium Channel; NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Flupirtine maleate (Katadolon maleate) 是可透过血脑屏障的、具有口服活性的非阿片类化合物。它是间接 NMDAR 拮抗剂,可用于缓解疼痛的研究,具有神经保护特性。 | |||
T5159 |
Olodaterol hydrochloride
BI-1744 HCl,盐酸奥达特罗,BI 1744 hydrochloride |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Olodaterol hydrochloride (BI-1744 HCl) 是一种长效的、选择性 β2-adrenoceptor(β2-AR) 激动剂 (EC50=0.1 nM;pKi= 9.14 for human β2-adrenoceptor),可用于慢性阻塞性肺疾病 (COPD) 和肺纤维化的研究。 | |||
T20720 |
Norethisterone enanthate
NSC 9564,Norethindrone enanthate,LG-202,LG202,NSC9564,LG 202,炔诺酮庚酸酯,NSC-9564 |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Norethisterone enanthate (NSC-9564) 是一种口服有效的长效的孕激素。 | |||
T0373 |
Erlotinib
OSI-744,NSC 718781,CP358774,埃罗替尼,R1415 |
EGFR; Autophagy | Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Erlotinib (CP358774) 是一种 EGFR 一代抑制剂,抑制 EGFR 19 Del 和 L858R 突变。Erlotinib 具有抗肿瘤活性,用于治疗 EGFR 突变的非小细胞肺癌。Erlotinib 用药会产生 EGFR C797S 耐药突变。 | |||
T3457 |
Olodaterol
BI1744,Striverdi Respimat |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Olodaterol 是一种长效的、选择性 β2-adrenoceptor(β2-AR) 激动剂 (EC50=0.1 nM;pKi= 9.14 for human β2-adrenoceptor),可用于慢性阻塞性肺疾病 (COPD) 和肺纤维化的研究。 | |||
T2390 |
Cevimeline hydrochloride hemihydrate
|
AChR | Neuroscience |
Cevimeline hydrochloride hemihydrate 是乙酰胆碱的奎尼丁衍生物,也是选择性的和口服活性的毒蕈碱型M1和M3受体激动剂。它可穿过血脑屏障,刺激唾液腺分泌,用作口干症的催涎剂。 | |||
T0364L |
Dibucaine hydrochloride
Cinchocaine HCl,Dibucaine HCl,盐酸地布卡因,Cinchocaine hydrochloride |
Sodium Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
Dibucaine hydrochloride (Cinchocaine hydrochloride) 是钠通道抑制剂和有效的 SChE 抑制剂。 | |||
T33386 |
Milveterol HCl
Milveterol,GSK-159797,GSK 159797,GSK159797 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Milveterol HCl 是一种长效β(2)-肾上腺素能受体激动剂,可用于治疗慢性阻塞性肺病(COPD)。 | |||
T31716 |
Etidocaine Hydrochloride
W-19053,Duranest,W19053,W 19053 |
Sodium Channel | Membrane transporter/Ion channel |
Etidocaine Hydrochloride (W19053) 是一种长效麻醉剂和电压门控钠通道阻滞剂。 | |||
T0749 |
Succinylsulfathiazole
琥珀酰磺胺噻唑,Succinylsulphathiazole |
Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Succinylsulfathiazole (Succinylsulphathiazole) 是一种超长效磺胺类药物。 | |||
T4548 |
Procaterol hydrochloride
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Procaterol hydrochloride 用于治疗哮喘的短效β2-肾上腺素受体激动剂。 | |||
T68087 |
Inaperisone
|
Others | Others |
Inaperisone 是一种新型的中枢作用的肌肉松弛剂,对排尿反射有抑制作用。Inaperisone 可能通过间接作用于脑干的GABAB 受体来抑制排尿反射。 | |||
T4499 |
Mequitazine
Metaplexan,Virginan,Primalan,LM-209,美喹他嗪 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Mequitazine (Virginan) 是一种有效的、非镇静剂和长效组胺 H1 拮抗剂。 | |||
T4551 |
Acrivastine
Acrivastin,阿伐斯汀,BW825C,Semprex |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Acrivastine (Acrivastin) 是一种短效组胺 1 受体拮抗剂,可用于研究过敏性鼻炎。 | |||
T1629 |
Rifapentine
MDL473,Rifapentina,Rifapentinum,DL 473,利福喷丁,Priftin,Cyclopentylrifampicin |
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Rifapentine (Rifapentinum) 是可用于肺结核的抗生素。 | |||
T28360 |
PF-00489791
PF-4634817,PF 4634817,PF00489791,PF 00489791,PF4634817 |
PDE | Metabolism |
PF-00489791 (PF4634817) 是一种长效 PDE5 抑制剂,具有降血压活性,可用于研究糖尿病肾病。 | |||
T3288 |
Sulfisomidin
Sulfisomidine,Sulfadimetine,磺胺二甲基异嘧啶,sulfamethin,磺胺二甲异嘧啶,Sulfaisodimidine |
Antibacterial; Antibiotic | Microbiology/Virology |
Sulfisomidin (Sulfaisodimidine) 是一种具有口服活性的短效磺酰胺类抗菌剂。它可研究下尿路感染。 | |||
T1239 |
Indacaterol maleate
马来酸茚达特罗,QAB149 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Indacaterol maleate (QAB149) 是一种超长效的 β-肾上腺素受体激动剂。 | |||
T26939 |
Cadralazine
ISF 2469,卡屈嗪,ISF-2469,ISF2469 |
Others | Others |
Cadralazine (ISF 2469) 是一种外周小动脉血管扩张剂,可用于作为抗高血压药物的研究。 | |||
T0747 |
Sulfathiazole
2-Sulfanilamidothiazole,磺胺噻唑 |
Antibacterial; Antibiotic; Autophagy | Autophagy; Microbiology/Virology |
Sulfathiazole (2-Sulfanilamidothiazole) 是一种短效磺胺类抗生素。 | |||
T0015 |
Mephenesin
Cresoxydiol,甲酚甘油醚,Memphenesin,Mephedan,Decontractyl |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
Mephenesin (Cresoxydiol) 是 NMDA 受体拮抗剂,也是中枢性肌松弛剂。 | |||
TP1351L |
Kemptide TFA
|
Others | Others |
Kemptide TFA (65189-71-1 free base) 是一种合成七肽,可作为 cAMP 依赖性蛋白激酶 (PK) 的底物。 | |||
T6876 |
Liraglutide
利拉鲁肽,Liraglutidum,利拉糖肽,Victoza,Liraglutida,NN2211 |
Glucagon Receptor | GPCR/G Protein |
Liraglutide (Liraglutida) 是胰高血糖素样肽-1 受体激动剂,用于 2 型糖尿病的研究。 | |||
T23969 |
DCAI
|
Others | Others |
DCAI 是一种核苷酸交换和核苷酸释放的抑制剂,通过与 Ras-SOS 界面附近的口袋结合而起作用。 | |||
T0504 |
Cyclandelate
安脉生,BS 572,环扁桃酯,3,5,5-Trimethylcyclohexyl mandelate |
Acyltransferase | Metabolism |
Cyclandelate (BS 572) 是直接作用的平滑肌松弛剂,用于扩张血管。 | |||
T34146 |
Propanidid
FBA 1420,Epontol,Sombrevin,Fabontal,Fabantol |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Propanidid (Sombrevin) 是一种 γ-氨基丁酸 A 型受体 (GABAA) 激动剂,也是一种可快速发挥作用的静脉注射麻醉剂,可以降低动脉血压。 | |||
T22508 |
3-CPMT
Chlortropbenzyl hydrochloride,3-[(4-chlorophenyl)-phenylmethoxy]-8-methyl-8-azabicyclo[3.2.1]octane hydrochloride,SL6057,Wy 2149,FC-1 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
3-CPMT (FC-1) 是一种多巴胺摄取抑制剂和一种有效的长效抗组胺剂。 | |||
T6992 |
Sulfadiazine sodium
Sulfadiazin-natrium,磺胺嘧啶钠,Sodium sulfadiazine |
Others; Antibacterial; Antibiotic; Parasite | Microbiology/Virology; Others |
Sulfadiazine sodium (Sulfadiazin-natrium) 是一种磺胺类抗生素具有抗疟活性,可研究弓形虫病。 | |||
T7118 |
Dimethocaine
二甲卡因,Larocaine |
Others; Dopamine Receptor | GPCR/G Protein; Neuroscience; Others |
Dimethocaine (Larocaine) 是一种局部麻醉剂,也对中枢神经系统起多巴胺再摄取抑制剂的作用。 | |||
T4119 |
Octreotide Acetate
醋酸奥曲肽,SMS 201995,Longastatin,Sandostatin,SMS 201-995 (acetate) |
Somatostatin | GPCR/G Protein |
Octreotide Acetate (Sandostatin) 是一种长期有效的合成生长抑素八肽类似物,可抑制生长激素的分泌。 | |||
T0127 |
Glimepiride
Glimperide,HOE-490,格列美脲 |
Potassium Channel | Membrane transporter/Ion channel |
Glimepiride (HOE-490) 是一种中长效的磺酰脲类抗糖尿病化合物,其 ED50=182 μg/k。 | |||
T1645 |
Ramipril
HOE-498,Tritace,雷米普利,Altace,Carasel |
Apoptosis; RAAS | Apoptosis; Endocrinology/Hormones |
Ramipril (Altace) 是一种ACE 抑制剂,IC50为5 nM。 | |||
T1446 |
Bambuterol hydrochloride
(±)-Bambuterol hydrochloride,盐酸班部特罗,盐酸班布特罗,KWD-2183 hydrochloride,Bambuterol HCl |
Adrenergic Receptor; AChR | GPCR/G Protein; Neuroscience |
Bambuterol hydrochloride (KWD-2183 hydrochloride) 是 Terbutaline 的前体药物,是一种肾上腺素受体长效激动剂。 | |||
T6652 |
Salbutamol hemisulfate
Ventolin Sulfate,沙丁胺醇半硫酸盐,Albuterol,Salbutamol Sulfate,硫酸沙丁胺醇,Bronchospray,Albuterol Sulfate |
Adrenergic Receptor; Autophagy | Autophagy; GPCR/G Protein; Neuroscience |
Salbutamol hemisulfate (Albuterol Sulfate) 是一种短效的β2肾上腺素受体激动剂,IC50 为 8.93 μM。 | |||
T31716L |
Etidocaine
|
Others | Others |
Etidocaine 是一种氨基酸酰胺,用作局部麻醉剂,具有快速起效和长效特性。 | |||
T19858 |
Brodimoprim
|
DHFR; Antibacterial | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Brodimoprim 是甲氧苄啶的一种类似物,是口服有效的二氢叶酸还原酶抑制剂,对广谱革兰氏阴性和革兰氏阳性细菌具有高度的抑制作用。 | |||
T35048 |
Verofylline
CK 0383,Verofilina,CK-0383,Verofyllinum,CK0383 |
PDE | Metabolism |
Verofylline (Verofyllinum) 是一种可口服的长效多效取代甲基黄嘌呤支气管扩张剂,对 PDE4 具有抑制作用,可用于治疗哮喘疾病研究肥胖症。 | |||
T25263 |
Clopimozide
R-29764,NSC-335305,NSC 335305,NSC335305,R 29764 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Clopimozide (R-29764) 可作为一种钙通道拮抗剂,抑制 [3H] 尼群地平结合。Clopimozide 是一种新型且可口服的长效抗精神分裂症精神安定化合物。 | |||
T30785 |
Cefacetrile
Cefacetrilum,Cefacetrilo,Celospor,Cephacetrile,Cefacetril |
Antibiotic | Microbiology/Virology |
Cefacetrile (Cephacetrile) 是一种广谱的头孢类抗生素,具有抗菌活性,可用于研究革兰氏菌感染,作用与头孢噻吩作用。 | |||
T16509 |
PF-610355
PF-00610355,PF 610355,PF-610,355,PF610355 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
PF-610355 是一种具有长效性和高效性的β2 肾上腺素能受体激动剂(EC50:0.26 nM)。PF-610355 可用于研究哮喘和 COPD 。 | |||
T2150 |
Guanfacine hydrochloride
盐酸胍法辛,Tenex,Intuniv,Guanfacine |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Guanfacine hydrochloride (Intuniv) 是一种 α2A 肾上腺素受体激动剂,Kd=31 nM,具有抗高血压作用。 | |||
T8748 |
Exendin-4 acetate
|
Glucagon Receptor | GPCR/G Protein |
Exendin-4 acetate 是一种长效的 glucagon-likepeptide-1 受体激动剂(IC50:3.22 nM),是一种由39个氨基酸组成的多肽。。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3327 |
Artemotil
SM-227,β-Arteether,Beta-Arteether,蒿乙醚,Arteether,(+)-Arteether |
CXCR; CCR; Parasite | Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology |
Artemotil (SM-227) 是一种新型的速效抗疟药,可研究耐Plasmodium falciparum 的恶性疟原虫疟疾,IC50值为 1.61 nM。 | |||
TN1128 |
Bruceine E
|
Others | Others |
Bruceine E 是从 B. javanica 种子中分离得到的,具有降血糖作用。 Bruceine E 可用于作为胰岛素促分泌剂的研究。 | |||
TN1927 |
Methyl Kakuol
1-(6-methoxy-1,3-benzodioxol-5-yl)propan-1-one |
TRP/TRPV Channel | Membrane transporter/Ion channel |
Methyl Kakuol 是 TRPA1 的激动剂,EC50 为 0.27 µM,可用于作为 MBST 成分 Asiasari Radix 的活性成分的研究。 | |||
T2796 |
Coenzyme Q10
Ubiquinone-10,辅酶Q10,CoQ10 |
Ferroptosis; Reactive Oxygen Species; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB |
Coenzyme Q10 (CoQ10)是来自藤仓赤霉菌的一种天然产物,在线粒体呼吸链中充当电子载体。 | |||
TN1372 |
Alpha-Amyrin
alpha-Amyrenol,α-Amyrin,alpha-Amyrine,Viminalol,α-香树脂醇 |
P450; Serine Protease; ROS | Immunology/Inflammation; Metabolism; Proteases/Proteasome |
Alpha-Amyrin (alpha-Amyrine) 是一种具有抗肿瘤作用的胰蛋白酶和糜蛋白酶抑制剂。 alpha-Amyrin 可用于作为肝调节剂的研究。 | |||
T0268 |
Lobeline hydrochloride
盐酸洛贝林,α-Lobeline hydrochloride,L-Lobeline hydrochloride |
AChR | Neuroscience |
Lobeline hydrochloride (α-Lobeline hydrochloride) 是一种烟碱样受体激动剂,是神经元烟碱受体α3β2和α4β2拮抗剂。 | |||
TN2148 |
Retusin
5-Hydroxy-3,7,3',4'-tetramethoxyflavone,Quercetin-3,7,3',4'-tetramethyl ether |
ATPase; Free radical scavengers; Tyrosinase | Membrane transporter/Ion channel; oxidation-reduction; Proteases/Proteasome |
Retusin 是从 Talinum triangulare 的叶子中提取的。 Retusin Retusin 可用于作为芽前和芽后除草剂的研究。 | |||
T2983 |
3,4,5-Trimethoxycinnamic acid
3-(3,4,5-Trimethoxyphenyl)acrylic Acid,O-Methylsinapic acid,3,4,5-三甲氧基肉桂酸 |
GABA Receptor; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) 是从远志中分离得到的苯丙素类天然产物,可延长动物的睡眠时间,增强 GAD65 和 GABAA 受体 γ 亚基,具有抗应激作用。 | |||
T3S2007 |
MRE-269
3-氧代-12-烯-28-乌苏酸,MRE 269,ACT-333679,MRE269 |
Prostaglandin Receptor | GPCR/G Protein; Immunology/Inflammation |
MRE-269 (ACT-333679) 是一种口服的长效前列环素受体激动剂前药,是 Selexipag 的活性代谢物,用于治疗肺动脉高压。 | |||
T0965 |
Histamine
Ergamine,组胺 |
5-HT Receptor; Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Histamine (Ergamine) 是通过组胺的酶促脱羧衍生的胺。它是一种强大的胃分泌兴奋剂、支气管平滑肌的收缩剂、血管扩张剂以及中枢作用的神经递质。 | |||
T1261 |
Medroxyprogesterone Acetate
Medroxyprogesterone 17-acetate,Provera,Metigestrona,NSC-26386,醋酸甲羟孕酮,Farlutin,安宫黄体酮,Medroxyprogesterone (acetate) |
Glucocorticoid Receptor; Estrogen/progestogen Receptor; Progesterone Receptor; Androgen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism; Others |
Medroxyprogesterone Acetate (Farlutin) 是广泛使用的合成类固醇,与雄激素,孕酮及糖皮质激素受体均有作用。 | |||
T0086 |
Galanthamine hydrobromide
Galantamine hydrobromide,Galanthamine HBr,氢溴酸加兰他敏 |
AChR; AChE | Neuroscience |
Galanthamine hydrobromide (Galantamine hydrobromide) 是一种长效的中枢活性 AChE 抑制剂,IC50为 410 nM。它是神经元烟碱型 ACh 受体的变构增强剂,IC50值为 0.35 µM,可用于阿尔茨海默症的研究。 | |||
T0012 |
Cinchonine
LA40221,(8R,9S)-Cinchonine,奎宁树,辛可宁 |
Apoptosis; P-gp; Parasite | Apoptosis; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience |
Cinchonine (LA40221) 是金鸡纳树皮中的一种天然产物。它可激活内质网应激诱导的人肝癌细胞凋亡。它是一种酰胺类局部麻醉剂。 | |||
TN1202 |
(-)-α-Pinene
左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene |
Virus Protease; GABA Receptor; Endogenous Metabolite; Antibacterial | Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience |
(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) 是一种单萜类化合物,通过延长 GABAergic 突触传递、作为 GABAA-BZD 受体的部分调节剂并直接与 GABAA 受体的 BZD 结合位点结合来增强 NREMS 的数量而不影响 NREMS 的强度。 | |||
T2S2108 |
Coixol
薏苡素,6-methoxybenzoxazolone,6-MBOA,6-Methoxy-2-benzoxazolinone,MBOA |
Others; Antibacterial | Microbiology/Virology; Others |
Coixol (MBOA) 是一种从薏苡仁中提取的多酚,有抗菌和抗肿瘤作用。 | |||
TCS1704 |
Artemitin
艾黄素,Artemetin,Artemisetin,Erianthin |
Antioxidant | oxidation-reduction |
Artemitin (Erianthin) 是一种存在于翼齿六棱菊中的天然黄酮,具有抗氧化、抗炎、抗病毒活性。 | |||
TN1413 |
Atranorin
荔枝素,巴美灵,荔枝素 |
Endogenous Metabolite; NO Synthase; Ras | GPCR/G Protein; Immunology/Inflammation; MAPK; Metabolism |
Atranorin 是地衣的次生代谢产物,具有显着的抗伤害、抗炎和氧化还原活性,对 H(2)O(2) 诱导的氧化应激下的细胞具有细胞保护作用。 | |||
T11680 |
Isoasatone A
|
P450 | Metabolism |
Isoasatone A 是一种具有抗虫作用的天然产物,分离自Heterotropa takaoiM。它作用于细胞色素 P450 单加氧酶和谷胱甘肽转移酶,产生抗S. litura 作用。 | |||
T6534 |
Histamine dihydrochloride
组胺二盐酸盐,peremin,Ceplene,Histamine 2HCl |
Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Histamine dihydrochloride (Ceplene) 是 Histamine 的二盐酸形式。Histamine 是一种有机氮化合物,是一种强效的胃分泌兴奋剂,支气管平滑肌收缩剂,血管舒张剂,也是一种中枢作用的神经递质。 | |||
T8183 |
Deslanoside
洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C |
ATPase; Drug Metabolite | Membrane transporter/Ion channel; Metabolism |
Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷,可抑制Na-K-ATPase 膜泵,导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常,并在研究慢性心房颤动时控制心室率。 | |||
T3392 |
Sinapine thiocyanate
|
P-gp; AChE | Membrane transporter/Ion channel; Neuroscience |
Sinapine thiocyanate 是萝卜中分离出来的一种生物碱,具有抗炎、抗氧化、抗肿瘤、抗血管生成和放射防护作用。它还是乙酰胆碱酯酶抑制剂,可用于研究阿尔茨海默症,共济失调,重症肌无力和帕金森氏病。 | |||
TC0022 |
Desoxypeganine
Deoxypeganine |
AChE | Neuroscience |
Desoxypeganine (Deoxypeganine) 是胆碱酯酶的抑制剂。它优先作用于丁酰胆碱酯酶,作为单胺氧化酶 A 而不是单胺氧化酶 B 的选择性抑制剂。它在酒精滥用的药理学治疗中的潜在用途,以减少酒精滥用者的渴望和抑郁,并且也可能有用作为戒烟辅助。 | |||
T2520 |
Desloratadine
Sch34117,地氯雷他定,NSC 675447 |
Endogenous Metabolite; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience |
Desloratadine (Sch34117) 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。 | |||
T3753 |
Sinapinic Acid
Sinapic acid,芥子酸,Synapoic acid |
Apoptosis; RAAS; Reactive Oxygen Species; HDAC | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Endocrinology/Hormones; Immunology/Inflammation; Metabolism; NF-κB |
Sinapinic Acid (Synapoic acid) 是从 Hydnophytum formicarumJack. 根中分离到的酚类,是HDAC 抑制剂,对ACE-I 的活性也有抑制作用。它有抗肿瘤活性,诱导肿瘤细胞凋亡,具有抗氧化、抗糖尿病的作用。 | |||
T3929 |
Kaurenoic acid
Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid |
Others | Others |
Kaurenoic acid (kaurenoate) 是一种二萜,来源于 Sphagneticola trilobata 中,可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路,并抑制炎症疼痛。 | |||
T31911 |
Ganodermic acid S
Ganoderic acid R |
Others | Others |
Ganodermic acid S, as a membrane acting agent isolated from the fungus Ganoderma lucidum, exerts multiple effects on human platelet function. | |||
TN2120 |
Quassin
|
Others; Antifection | Microbiology/Virology; Others |
Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion. | |||
TN6565 |
Maculosidin
|
||
Maculosidine affect the PS I electron acceptors on leaf discs, it can inhibit ATP synthesis, basal, phosphorylating and uncoupled electron transport acting as Hill reaction inhibitors on spinach chloroplasts. | |||
TN2306 |
Wilfordine
|
ATPase; Potassium Channel; Sodium Channel | Membrane transporter/Ion channel |
Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect. | |||
T38497 |
(-)-Taxifolin
(-)-二氢槲皮素,(-)-Dihydroquercetin |
Others | Others |
(-)-Taxifolin is the less active enantiomer of Taxifolin, demonstrating vital anti-tyrosinase activity and notable inhibition against collagenase (IC50 = 193.3 μM). It is valued as an essential natural compound showing antifibrotic potential, while also acting as a capable free radical scavenger and possessing antioxidant capacity. | |||
TN2176 |
Sanggenol A
|
Influenza Virus; Antifection | Microbiology/Virology |
Sanggenol A 抑制甲型流感病毒和肺炎球菌神经氨酸酶,因此可作为双重作用的抗感染试剂。 | |||
TN2222 |
Sotetsuflavone
|
Others | Others |
Sotetsuflavone is a potent inhibitor of DENV-NS5 RdRp (Dengue virus NS5 RNA-dependent RNA polymerase) with an IC50 of 0.16 μM, is the most active compound of this series. | |||
TN2050 |
Peonidin-3-O-glucoside chloride
Peonidin 3-Glucoside Chloride |
Free radical scavengers | oxidation-reduction |
Peonidin-3-O-glucoside chloride (Peonidin 3-Glucoside Chloride) 是一种具有自由基清除活性的花青素,可用于作为胰岛素促分泌剂的研究。 | |||
TN3802 |
Dehydrodiconiferyl alcohol
|
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Dehydrodiconiferyl alcohol (DHCA) 是一种从葫芦中分离出来的木脂素,通过作为雌激素受体激动剂抑制破骨细胞分化和卵巢切除术诱导的骨质流失。 | |||
TN4185 |
Hautriwaic acid
|
||
Hautriwaic acid shows anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA) mice ear edema models, it diminishes the joint edema induced by this mixture of polysaccharides (carrageenan), possibly by acting as immunomodulator of the infl | |||
T72459 |
3-Oxo-hop-22(29)-ene
|
Others | Others |
3-Oxo-hop-22(29)-ene 是一种yeast α-glucosidase 抑制剂。3-Oxo-hop-22(29)-ene 具有中等的抗克氏锥虫和抗墨西哥利什曼原虫活性。3-Oxo-hop-22(29)-ene 具有微弱的抗炎活性。 | |||
T73812 |
Phosphatidylinositol 4,5-bisphosphate
|
Others | Others |
Phosphatidylinositol 4,5-bisphosphate(L-alpha-Phosphatidylinositol-4,5-bisphosphate)为细胞膜磷脂成分,主要作为磷脂酶C(PLC)与磷酸肌醇3-激酶(PI3K)的底物,充当重要信使。 | |||
TN7273 |
(±)7-epi Jasmonic Acid
2-iso Jasmonic Acid |
Others | Others |
(±)-7-epiJasmonic acid, the primary metabolite in the 12-oxo phytodienoic acid pathway of 13(S)-hydroperoxy linolenic acid metabolism in plants, is synthesized initially as the more active (+)-7-epijasmonic acid. It quickly epimerizes to the more stable (−)-7-jasmonic acid isomer, demonstrating its biological relevance. Acting as a plant growth regulator, (±)-7-epiJasmonic acid triggers various signal transduction pathways, which can either promote growth or inhibit it, likely as a response to s... | |||
TN5280 |
(-)-Zeylenol
Zeylenol |
Apoptosis | Apoptosis |
(-)-Zeylenol (Zeylenol) 是一种从 Uvaria grandiflora 的茎中提取的天然产物,具有抗炎、拒食和抗肿瘤生物活性,通过抑制多种炎症介质的合成或释放发挥作用。 zezelenol 对油菜根系生长有抑制作用,具有诱导人乳腺癌 MDA-MB231细胞凋亡的潜力。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01460 |
ABHD4 Protein, Human, Recombinant (His)
abhydrolase domain containing 4,ABH4 |
Human | Baculovirus Insect Cells |
Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain containing (ABHD) gene was a small group belongs to alpha/beta hydrolase superfamily. Known members of this group are all found to be involved in important biochemical processes and related to various diseases. The alpha/beta-hydrolase 4 (ABH4) is a lysophospholipase/phospholipa... | |||
TMPJ-01466 |
Osteoprotegerin Protein, Human, Recombinant (aa 22-401, His)
OPG,Tumor Necrosis Factor Receptor Superfamily Member 11B,OC... |
Human | HEK293 Cells |
TNFRSF11B is a secreted protein, containing 2 death domains and 4 TNFR-Cys repeats. TNFRSF11B is a decoy receptor for the receptor activator of nuclear factor kappa B ligand (RANKL). By binding RANKL, TNFRSF11B inhibits nuclear kappa B (NF-κB) which is a central and rapid acting transcription factor for immune-related genes, and a key regulator of inflammation, innate immunity, and cell survival and differentiation. TNFRSF11B levels are influenced by voltage-dependent calcium channelsCav1.2. TNF... | |||
TMPY-04552 |
AKT1 Protein, Human, Recombinant (His)
RAC-ALPHA,v-akt murine thymoma viral oncogene homolog 1,RAC,... |
Human | Baculovirus Insect Cells |
v-akt murine thymoma viral oncogene homolog 1 (AKT1), or protein kinase B-alpha (PKB-ALPHA) is a serine-threonine protein kinase, belonging to the Protein Kinase Superfamily. AKT1 is a major mediator of the responses to insulin, insulin-like growth factor 1 (IGF1), and glucose. AKT1 also plays a key role in the regulation of both muscle cell hypertrophy and atrophy. AKT1 activity is required for physiologic cardiac growth in response to IGF1 stimulation or exercise training. In contrast, AKT1 ac... | |||
TMPH-03764 |
YAP1 Protein, Human, Recombinant (His)
YAP1-2gamma,YAP2L,YAP65 |
Human | P. pastoris (Yeast) |
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,... | |||
TMPY-01104 |
Coagulation factor XI/F11 Protein, Human, Recombinant (His)
coagulation factor 11,coagulation factor XI,FXI |
Human | HEK293 Cells |
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa ... | |||
TMPH-00599 |
LDCC Protein, E. coli, Recombinant (His)
ldcC,Constitutive lysine decarboxylase |
E. coli | E. coli |
Plays a role in lysine utilization by acting as a lysine decarboxylase. | |||
TMPH-00546 |
Epstein-Barr virus (strain GD1) BARF1 Protein (His)
33 kDa early protein,BARF1,p33,Secreted protein BARF1 |
EBV | E. coli |
Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro. | |||
TMPH-00547 |
Epstein-Barr virus (strain B95-8) BARF1 Protein (His & Myc)
33 kDa early protein,p33,Secreted protein BARF1 |
EBV | E. coli |
Plays diverse functions in immunomodulation and oncogenicity, maybe by acting as a functional receptor for human CSF1. May inhibit interferon secretion from mononuclear cells. Exhibits oncogenic activity in vitro. | |||
TMPH-00963 |
Ataxin-2 Protein, Human, Recombinant (His)
TNRC13,ATX2,ATXN2,Ataxin-2,Trinucleotide repeat-containing g... |
Human | E. coli |
Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. Ataxin-2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.0 kDa and the accession number is Q99700. | |||
TMPH-03558 |
LytM Protein, S. aureus, Recombinant (His)
Autolysin LytM,Glycyl-glycine endopeptidase LytM,lytM |
Staphylococcus aureus | E. coli |
Peptidoglycan hydrolase (autolysin) specifically acting on polyglycine interpeptide bridges of the cell wall peptidoglycan. LytM Protein, S. aureus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.9 kDa and the accession number is O33599. | |||
TMPY-05058 |
TMX1 Protein, Human, Recombinant (mFc)
thioredoxin-related transmembrane protein 1,PDIA11,TXNDC,TXN... |
Human | HEK293 Cells |
As a thiol-based tumor suppressor, TMX1 increases mitochondrial ATP production and apoptosis progression. TMX1 is the first example of a topology-specific client protein redox catalyst acting both in the folding and in the degradative pathways. | |||
TMPH-02250 |
TPP2 Protein, Human, Recombinant (His & Myc)
Tripeptidyl-peptidase II,Tripeptidyl aminopeptidase,Tripepti... |
Human | Baculovirus Insect Cells |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. | |||
TMPH-02153 |
Sulfiredoxin-1 Protein, Human, Recombinant (His & Myc)
SRXN1,Sulfiredoxin-1 |
Human | E. coli |
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. | |||
TMPH-01461 |
HNRNPA3 Protein, Human, Recombinant (His & Myc)
Heterogeneous nuclear ribonucleoprotein A3,HNRNPA3 |
Human | E. coli |
Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing. HNRNPA3 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 46.6 kDa and the accession number is P51991. | |||
TMPH-00083 |
Dehydrin ERD14 Protein, Arabidopsis thaliana, Recombinant (His & Myc)
ERD14,Dehydrin ERD14 |
Arabidopsis thaliana | E. coli |
Intrinsically disordered protein acting as a chaperone. Prevents heat-induced aggregation and/or inactivation of various substrates. Binds to acidic phospholipid vesicles without affecting membrane fluidity. Dehydrin ERD14 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.1 kDa and the accession number is P42763. | |||
TMPH-01343 |
FILIP1 Protein, Human, Recombinant (His & Myc)
FILIP1,Filamin-A-interacting protein 1 |
Human | E. coli |
By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A. FILIP1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 30.2 kDa and the accession number is Q7Z7B0. | |||
TMPH-02595 |
Collectrin Protein, Mouse, Recombinant (His & Myc & SUMO)
Cltrn,Collectrin,Tmem27,Nx17,Transmembrane protein 27 |
Mouse | E. coli |
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication. | |||
TMPH-00225 |
APOA1 Protein, Bovine, Recombinant (His)
Apolipoprotein A-I,APOA1,ApoA-I,Apo-AI,Apolipoprotein A1 |
Bovine | P. pastoris (Yeast) |
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. APOA1 Protein, Bovine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.5 kDa and the accession number is P15497. | |||
TMPH-02953 |
TPP2 Protein, Mouse, Recombinant (His & Myc)
Tripeptidyl aminopeptidase,Tripeptidyl-peptidase 2,Tripeptid... |
Mouse | Baculovirus Insect Cells |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. TPP2 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 28.3 kDa and the accession number is Q64514. | |||
TMPH-01567 |
IZUMO1 Protein, Human, Recombinant (His & Myc)
Izumo sperm-egg fusion protein 1,IZUMO1,Sperm-specific prote... |
Human | E. coli |
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. | |||
TMPH-03762 |
TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc)
Tpp2,Tripeptidyl-peptidase 2,Tripeptidyl aminopeptidase,Trip... |
Mouse | E. coli |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 29.5 kDa and the accession number is Q64514. | |||
TMPH-00224 |
APOA1 Protein, Bovine, Recombinant (E. coli, His)
APOA1,Apolipoprotein A-I,ApoA-I,Apo-AI,Apolipoprotein A1 |
Bovine | E. coli |
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. APOA1 Protein, Bovine, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.6 kDa and the accession number is P15497. | |||
TMPH-03757 |
TPP2 Protein, Human, Recombinant (E. coli, His & Myc)
TPP2,Tripeptidyl-peptidase II,Tripeptidyl-peptidase 2,Tripep... |
Human | E. coli |
Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited. Stimulates adipogenesis. TPP2 Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.8 kDa and the accession number is P29144. | |||
TMPH-01973 |
Proteoglycan 4 Protein, Human, Recombinant (His)
PRG4,Megakaryocyte-stimulating factor,Superficial zone prote... |
Human | P. pastoris (Yeast) |
Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface.; Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. Proteoglycan 4 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 1... | |||
TMPJ-01202 |
LYG2 Protein, Human, Recombinant (His)
LYGH,Lysozyme G-Like Protein 2,LYG2 |
Human | HEK293 Cells |
Lysozyme G-Like Protein 2 (LYG2) is a secreted protein that belongs to the glycosyl hydrolase 23 family. LYG2 contains one SLT domain, one protein domain present in bacterial lytic transglycosylase (SLT) and in eukaryotic lysozymes (GEWL). SLT domain catalyzes the cleavage of the β-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyglucosamine (GlcNAc). LYG2 has hydrolase activity which acting on glycosyl bonds, and possess lysozyme activity. | |||
TMPJ-01429 |
SARS-CoV-2 Guanine-N7 methyltransferase Protein (His)
SARS-CoV 2 nsp14,Guanine-N7 methyltransferase,SARS-CoV 2 Exo... |
SARS-CoV-2 | E. coli |
The nonstructural protein (nsp) 14 of SARS-CoV 2 was identified as a cap (guanine-N7)-methyltransferase (N7-MTase). Nsp14 of coronaviruses two different activities: an exoribonuclease activity acting on both ssRNA and dsRNA in a 3' to 5' direction and a N7-guanine methyltransferase activity. It may be involved in the proof-reading ability during the viral RNA replication and transcription. GTP, dGTP as well as cap analogs GpppG, GpppA and m7GpppG could be methylated by nsp14. | |||
TMPH-03550 |
EsxA Protein, S. aureus, Recombinant (His & SUMO)
esxA,Type VII secretion system extracellular protein A |
Staphylococcus aureus | E. coli |
Virulence factor that is important for the establishment of infection in the host. EsxA is required for EsxB synthesis as well as secretion. Modulates host cell apoptotic pathways and mediates together with EsxB the release of S.aureus from the host cell. By acting on apoptosis, plays a role in the modulation of dendritic cell-mediated immunity. EsxA Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 27.... | |||
TMPH-01463 |
HNRNPL Protein, Human, Recombinant (His & SUMO)
HNRNPL,Heterogeneous nuclear ribonucleoprotein L |
Human | E. coli |
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. HNRNPL Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6x... | |||
TMPJ-01395 |
NIP7 Protein, Human, Recombinant (His)
KD93,NIP7,60S Ribosome Subunit Biogenesis Protein NIP7 Homol... |
Human | E. coli |
60S Ribosome Subunit Biogenesis Protein NIP7 Homolog (NIP7) belongs to the NIP7 family. NIP7 contains one PUA domain, it is essential for the process of proper 27S pre-rRNA and 60S ribosome subunit assembly. NIP7 is a monomer form and interacts with NOL8 and SBDS, and may bind to RNA. In addition, NIP7 is one of the many trans-acting factors required for eukaryotic ribosome biogenesis, which interacts with nascent pre-ribosomal particles and dissociates as they complete maturation and are export... | |||
TMPK-00545 |
HPX Protein, Cynomolgus, Recombinant (His)
Hemopexin,Hpx,Hpxn |
Cynomolgus | HEK293 Cells |
Hemopexin (HPX) serves as scavenger and transporter of toxic plasma heme to the liver. HPX is formed by two four-bladed beta-propeller domains, resembling two thick disks that lock together at a 90 degrees angle. The heme is bound between the two beta-propeller domains in a pocket formed by the interdomain linker peptide.HPX, acting not only as a heme carrier but also displaying transient heme-based ligand binding and (pseudo-)enzymatic properties, could be considered a 'chronosteric' heme-prote... | |||
TMPJ-00606 |
Leptin Protein, Carassius auratus, Recombinant (His)
OB,Leptin,LEP,Obese Protein,OBS,Obesity Factor |
Carassius auratus | P. pastoris (Yeast) |
Leptin is a hormone secreted from white adipocytes and plays important role in the regulation of food intake and energy balance. Leptin functions via signaling pathways involving OB-R in hypothalamus. In mammals, leptin is mainly produced by the adipose tissue and encodes body fat reserves, acting as a short-term satiety signal. In fish, the presence of a leptin-like peptide was first evidenced by immuno-cross-reactivity, and its existence was certainly demonstrated after the finding by synteny ... | |||
TMPH-00423 |
Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His)
Tentoxylysin,Tetanus toxin,tetX |
Clostridium tetani | E. coli |
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His) is expressed in E. coli expression... | |||
TMPJ-00484 |
SHMT1 Protein, Human, Recombinant (His)
Serine Methylase,Glycine Hydroxymethyltransferase,Serine Hyd... |
Human | HEK293 Cells |
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to ... | |||
TMPJ-01428 |
SARS-CoV-2 NSP8 Protein (His)
SARS-CoV 2 nsp8 |
SARS-CoV-2 | E. coli |
Cleavage by the viral main protease, 3CLpro results in generating the nsp8 protein, The nsp8 protein has been shown to associate with several other nsps and to colocalize with these nsps in cytoplasmic complexes that are important for viral RNA synthesis. It forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acting as a primase. Alternatively, may synthesize substantially longer products than oligonucleotide primers.Nsp8 was shown to have RNA-dependen... | |||
TMPH-02126 |
SORBS2 Protein, Human, Recombinant (His)
Sorbin and SH3 domain-containing protein 2,Arg-binding prote... |
Human | E. coli |
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. SORBS2 Pro... | |||
TMPH-01273 |
TRIP12 Protein, Human, Recombinant (His & Myc)
Thyroid receptor-interacting protein 12,E3 ubiquiti... |
Human | E. coli |
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damag... | |||
TMPJ-01061 |
Nucleobindin-2 Protein, Human, Recombinant
NUCB2,NEFA,Gastric cancer antigen Zg4,Nesfatin-1,Prepronesfa... |
Human | E. coli |
Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage. Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic islets β-cells, gastric endocrine cells and adipocytes. Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner. Nesfatin-1 may ... | |||
TMPY-03055 |
LYG1 Protein, Human, Recombinant (His)
SALW1939,lysozyme G-like 1 |
Human | Baculovirus Insect Cells |
LYG1 (Lysozyme G1) is a Protein Coding gene. It belongs to the glycosyl hydrolase 23 family. Glycoside hydrolases are a widespread group of enzymes that hydrolyze the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. LYG1 exhibits hydrolase activity, acting on glycosyl bonds (inferred); lysozyme activity (inferred). It is found in the extracellular region and may function in the cell wall macromolecule catabolic process, metabolic process... | |||
TMPY-01816 |
Pentraxin 3 Protein, Human, Recombinant (His)
TNFAIP5,pentraxin 3,PTX3,TSG-14 |
Human | HEK293 Cells |
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cycl... | |||
TMPY-05001 |
MPZL3 Protein, Human, Recombinant (His)
UNQ2966/PRO7425,myelin protein zero-like 3 |
Human | HEK293 Cells |
MPZL3 (Myelin Protein Zero Like 3) is a Protein Coding gene. The encoded protein belongs to the myelin P0 protein family. MPZL3 is broadly expressed in skin, esophagus, and other tissues. MPZL3 was essential for normal differentiation, acting downstream of p63, ZNF750, KLF4, and RCOR1, each of which bound near the MPZL3 gene and controlled its expression. MPZL3 protein localized to mitochondria, where it interacted with FDXR, which was itself also found to be essential for differentiation. Toget... | |||
TMPJ-00092 |
CD8 beta Protein, Human, Recombinant (His)
T-Cell Surface Glycoprotein CD8 Beta Chain,CD8B1,CD8B,T-Cell... |
Human | HEK293 Cells |
T-Cell Surface Glycoprotein CD8β Chain (CD8 Antigen) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. CD8 Antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha a... | |||
TMPY-02444 |
ATF2 Protein, Human, Recombinant (His & GST)
CREB2,CRE-BP1,CREB-2,TREB7,activating transcription factor 2... |
Human | Baculovirus Insect Cells |
Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-activated protein kinases such as c-Jun N-terminal kinase and p38. ATF2 has been found to be a target of the JNK signal transduction pathway and mediate adenovirus E1A-inducible transcriptional activation. ATF2 is also been reported playing roles in TGF-β signaling pathway. It has ... | |||
TMPY-02952 |
SIAE Protein, Human, Recombinant (His)
CSE-C,AIS6,CSEC,LSE,YSG2,sialic acid acetylesterase |
Human | Baculovirus Insect Cells |
Sialate O-acetylesterase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. It is widely expressed with high expression in the testis, prostate, and colon. The systematic name of this enzyme class is N-acyl-O-acetylneuraminate O-acetylhydrolase. Other names in common use include N-acetylneuraminate acetyltransferase, sialate 9(4)-O-acetylesterase, and sialidase. Sialate O-acetylesterase catalyzes the removal of O-acetyl ester groups from position 9 of the p... | |||
TMPJ-01440 |
Cutinase Protein, Thermobifida fusca, Recombinant (His)
Cutinase |
Thermobifida fusca | E. coli |
Cutinase belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is cutin hydrolase. Cutinase is a serine esterase containing the classical Ser, His, Asp triad of serine hydrolases. The protein belongs to the alpha-beta class, with a central beta-sheet of 5 parallel strands covered by 5 helices on either side of the sheet. Cutin monomers released from the cuticle by small amounts of cutinase on fungal spore surfaces can g... | |||
TMPH-00536 |
Epstein-Barr virus (strain AG876) EBNA2 Protein (His & Myc)
Epstein-Barr nuclear antigen 2,EBNA2 |
EBV | P. pastoris (Yeast) |
Plays a key role in the activation of the host resting B-cell and stimulation of B-cell proliferation. Acts by up-regulating the expression of viral EBNA1-6, LMP1, LMP2A and LMP2B genes, as well as several host genes including CD21, CD23 and MYC. Activates transcription by acting as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins such as host CBF1, SMARCB1 and SPI1. Once EBNA2 is near promoter sites, its acidic activating domain recruits basal and activation-ass... | |||
TMPJ-01120 |
KPNB1 Protein, Human, Recombinant (His)
Nuclear factor p97,Importin subunit β-1,NTF97,Karyopherin su... |
Human | E. coli |
Importin subunit beta-1(KPNB1) is a member of the importin beta family. KPNB1 contains 1 importin N-terminal domain and 19 HEAT repeats. It is involved in nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. Its functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by ac... | |||
TMPY-03509 |
TCTP/TPT1 Protein, Human, Recombinant (His)
tumor protein, translationally-controlled 1,HRF,TCTP,p23,p02 |
Human | E. coli |
Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TPT1) (or P23) is a protein that has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first... | |||
TMPJ-00614 |
CD47 Protein, Rhesus macaque, Recombinant (His & Flag)
MER6,Integrin-Associated Protein,IAP,Leukocyte Surface Antig... |
Rhesus | HEK293 Cells |
CD47, also known as Integrin‑Associated Protein (IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain (ECD) with a single Ig‑like domain, five membrane-spanning regions with short intervening loops, and C‑terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important r... | |||
TMPY-04403 |
NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)
nemo-like kinase,LAK1 |
Human | Baculovirus Insect Cells |
Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. As a serine/threonine-protein kinase, Nemo-like kinase regulates some transcription factors with key roles in cell fate determination. It is a positive effector of the non-canonical Wnt signaling... | |||
TMPH-02186 |
TERT Protein, Human, Recombinant (His)
Telomerase reverse transcriptase,Telomerase catalytic subuni... |
Human | E. coli |
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22301 |
L-838417 D9
CTP354,CTP354 (C-21191),C-21191 |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
L-838417 D9 (C-21191) 是 L-838417 的氘代物。其中L-838417 是亚型选择性GABAA 正变构调节剂,在 α2, α3 和 α5 亚型中作为部分激动剂。 | |||
T10241 |
Acrivastine D7
BW825C D7 |
Others | Others |
Acrivastine D7 is a deuterium labeled Acrivastine. Acrivastine is a short acting antagonist of histamine 1 receptor. | |||
T13035 |
Sulfathiazole-d4
|
Others | Others |
Sulfathiazole D4 is a deuterium labeled Sulfathiazole. Sulfathiazole used as a short-acting sulfonamide antibiotic. | |||
T19234 |
Cetirizine D8 dihydrochloride
盐酸西替利嗪 D8 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Cetirizine D8 dihydrochloride is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist. | |||
T19233 |
Cetirizine D4 dihydrochloride
Cetirizine D4 dihydrochloride (1219803-84-5 free base) |
Others | Others |
Cetirizine D4 dihydrochloride is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist. | |||
T10770 |
Cetirizine D8
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Cetirizine D8 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist. | |||
T10769 |
Cetirizine D4
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Cetirizine D4 is a deuterium-labeled Cetirizine. Cetirizine is a second-generation antihistamine and a long-acting histamine H1-receptor antagonist. | |||
T11229 |
Erlotinib-d6
OSI-774 D6,NSC 718781 D6,CP-358774 D6 |
Others | Others |
Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR. Erlotinib D6 is a deuterium labeled Erlotinib . | |||
T13032 |
Sulfamonomethoxine-d4
|
Others | Others |
Sulfamonomethoxine D4 is a deuterium labeled Sulfamonomethoxine. Sulfamonomethoxine is an agent of long acting sulfonamide antibacterial, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate. | |||
TMID-0123 |
Rifapentine-d9
|
||
Rifapentine-d9 是 Rifapentine 的氘代化合物。Rifapentine 的 CAS 号为 61379-65-5。Rifapentine是可用于肺结核的抗生素。 | |||
TMIH-0453 |
Procaterol-d7
(Rac)-Procaterol-d7 |
||
Procaterol-d7 是 Procaterol 的氘代化合物。Procaterol 的 CAS 号为 81262-93-3。Procaterol hydrochloride用于治疗哮喘的短效β2-肾上腺素受体激动剂。 | |||
T11246 |
Etoricoxib-d4
MK-0663 D4,依托考昔 D4,L-791456 D4,Etoricoxib D4 |
Others | Others |
Etoricoxib D4 is a non steroidal anti-inflammatory agent, acting as a selective and orally active COX-2 inhibitor, with IC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood.Etoricoxib D4 is a deuterium labeled Etoricoxib. | |||
TMIJ-0082 |
Benserazide-d3 HCl
|
||
Benserazide-d3 HCl 是 Benserazide HCl 的氘代化合物。Benserazide HCl 的 CAS 号为 14919-77-8。Benserazide hydrochloride 是一种芳香族 L-氨基酸脱羧酶(AADC)的抑制剂,常用于帕金森病。 | |||
TMIJ-0073 |
Dapoxetine hydrochloride-d7
|
||
Dapoxetine hydrochloride-d7 是 Dapoxetine hydrochloride 的氘代化合物。Dapoxetine hydrochloride 的 CAS 号为 129938-20-1。Dapoxetine HCl 是一种具有口服活性的、选择性的血清素再摄取 (serotonin reuptake) 抑制剂 (SSRI),可用于研究早泄 (PE) 。 | |||
TMIJ-0444 |
Coenzyme Q10-d6
|
||
Coenzyme Q10-d6 是 Coenzyme Q10 的氘代化合物。Coenzyme Q10 的 CAS 号为 303-98-0。Coenzyme Q10是来自藤仓赤霉菌的一种天然产物,在线粒体呼吸链中充当电子载体。 | |||
T35915 |
Erlotinib-13C6
Erlotinib-13C6 |
||
Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]... | |||
TMIJ-0437 |
Sulfameter-d4
|
||
Sulfameter-d4 是 Sulfameter 的氘代化合物。Sulfameter 的 CAS 号为 651-06-9。Sulfameter是一种长效磺胺类抗生素,具有抗菌活性。它可研究尿路感染和麻风病。 | |||
TMIH-0583 |
Trelagliptin-13C-d3
|
||
Trelagliptin-13C-d3 是 Trelagliptin 的 13C 和氘代化合物。Trelagliptin 的 CAS 号为 865759-25-7。Trelagliptin 是一种有效的,具有口服活性的DPP-4抑制剂,IC50=4 nM。它可以改善体内血糖控制,能够用于2 型糖尿病 (T2DM) 的研究。 | |||
TMIJ-0216 |
Formoterol-13C-d3 Hemifumarate
|
||
Formoterol-13C-d3 Hemifumarate 是 Formoterol Hemifumarate 的 13C 和氘代化合物。Formoterol Hemifumarate 的 CAS 号为 43229-80-7。Formoterol Hemifumarate 是一种长效的 β2-肾上腺素受体激动剂。 | |||
TMIJ-0243 |
Etomidate-d5
|
||
Etomidate-d5 是 Etomidate 的氘代化合物。Etomidate 的 CAS 号为 33125-97-2。Etomidate 是有效的GABAA受体激动剂,可作为神经药物和肠胃外药物,具有用于内源性高皮质醇血症研究的潜力。 | |||
TMID-0267 |
Glipizide-d11
|
||
Glipizide-d11 是 Glipizide 的氘代化合物。Glipizide 的 CAS 号为 29094-61-9。Glipizide 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent),在 2 型糖尿病的研究中具有价值,但不适用于1 型糖尿病。Glipizide 是通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP)发挥活性 。 | |||
TMIJ-0005 |
Vilanterol-d4 Triphenylacetate
|
||
Vilanterol-d4 Triphenylacetate 是 Vilanterol Triphenylacetate 的氘代化合物。Vilanterol Triphenylacetate 的 CAS 号为 503070-58-4。Vilanterol trifenatate 是一种长效的β2-AR激动剂,效力持续24小时,能够作用于β2-AR (pEC50=10.37),β1-AR (pEC50=6.98) 和 β3-AR (pEC50=7.36)。 | |||
TMIH-0519 |
Selexipag Active Metabolite-d7
|
||
Selexipag Active Metabolite-d7 是 Selexipag Active Metabolite 的氘代化合物。Selexipag Active Metabolite 的 CAS 号为 475085-57-5。MRE269 是一种口服的长效前列环素受体激动剂前药,是 Selexipag 的活性代谢物,用于治疗肺动脉高压。 | |||
TMIH-0324 |
Medroxyprogesterone 17-Acetate-d3
|
||
Medroxyprogesterone 17-Acetate-d3 是 Medroxyprogesterone 17-Acetate 的氘代化合物。Medroxyprogesterone 17-Acetate 的 CAS 号为 71-58-9。Medroxyprogesterone acetate 是广泛使用的合成类固醇,与雄激素,孕酮及糖皮质激素受体均有作用。 | |||
TMIH-0512 |
Salbutamol-d3
|
||
Salbutamol-d3 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。 | |||
TMID-0233 |
Salbutamol-d9
|
||
Salbutamol-d9 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。 | |||
TMIJ-0202 |
Desloratadine-d5
|
||
Desloratadine-d5 是 Desloratadine 的氘代化合物。Desloratadine 的 CAS 号为 100643-71-8。Desloratadine 是非镇静H1抗组胺药 Loratadine 的主要口服代谢物,可减少对支气管平滑肌、毛细血管和胃肠道平滑肌中 H1 受体的典型组胺能作用,包括血管舒张、支气管收缩、血管通透性增加、疼痛、瘙痒和胃肠道平滑肌的痉挛性收缩。它是一种选择性H1受体拮抗剂,具有抗过敏和抗炎活性。 | |||
T38297 |
Ribavirin-13C5
Ribavirin-13C5 |
||
Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro... |