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Levocetirizine Dihydrochloride (Xyzal Dihydrochloride)是一种第三代外周H1受体拮抗剂。作为抗组胺化合物,它特异性地针对组胺H1受体。Levocetirizine Dihydrochloride 是西替利嗪的R-对映体,使其对H1受体的亲和力高于S-对映体。因此,Levocetirizine Dihydrochloride 在治疗过敏性鼻炎和慢性特发性荨麻疹方面有效。
Levocetirizine Dihydrochloride (Xyzal Dihydrochloride)是一种第三代外周H1受体拮抗剂。作为抗组胺化合物,它特异性地针对组胺H1受体。Levocetirizine Dihydrochloride 是西替利嗪的R-对映体,使其对H1受体的亲和力高于S-对映体。因此,Levocetirizine Dihydrochloride 在治疗过敏性鼻炎和慢性特发性荨麻疹方面有效。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | ¥ 113 | 现货 | |
25 mg | ¥ 167 | 现货 | |
50 mg | ¥ 228 | 现货 | |
100 mg | ¥ 322 | 现货 | |
200 mg | ¥ 463 | 现货 | |
500 mg | ¥ 765 | 现货 | |
1 g | ¥ 1,120 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 99 | 现货 |
产品描述 | Levocetirizine Dihydrochloride (Xyzal Dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Acting as an antihistaminic agent, it specifically targets the histamine H1-receptor. Levocetirizine Dihydrochloride is the R-enantiomer of Cetirizine, which gives it a higher affinity for the H1-receptor than the S-enantiomer. Due to this enhanced affinity, Levocetirizine Dihydrochloride is effective in treating allergic rhinitis and chronic idiopathic urticaria. |
体内活性 | Levocetirizine Dihydrochloride(0.4 mg/kg;口服;雄性斯普拉格-道利大鼠)治疗显示,在斯普拉格-道利大鼠中Cmax、AUC0-t、AUC0-∞ 以及 t1/2 分别为 0.34 μg/mL、3.26 μg h/mL、3.67 μg h/mL 和 2.34 小时[1]。 |
别名 | 盐酸左旋西替利嗪, Xyzal Dihydrochloride, (-)-Cetirizine Dihydrochloride |
分子量 | 461.81 |
分子式 | C21H27Cl3N2O3 |
CAS No. | 130018-87-0 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: 90 mg/mL (194.9 mM), Sonication is recommended. DMSO: 50 mg/mL (108.27 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
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