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Search Results for " tubulin "

Targets Recommended: Apoptosis Microtubule Associated Topoisomerase

367

抑制剂 & 化合物

50

天然产物

2

化合物库

21

重组蛋白

4

同位素标记化合物

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Cat. No.	Product Name
L1110	微管靶向化合物库		142 compounds
	142 种靶向微管的分子集合，用于高通量筛选和高内涵筛选；
L1310	细胞骨架化合物库		759 compounds
	759 种细胞骨架相关的化合物，可以用于高通量和高内涵筛选；

化合物库

微管靶向化合物库

Cat.No: L1110

Compounds: 142

细胞骨架化合物库

Cat.No: L1310

Compounds: 759

Cat. No.	Product Name	Target	Signaling Pathways
T77584	Tubulin inhibitor 35 Tubulin IN 35	Apoptosis; Microtubule Associated; Topoisomerase	Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair
	Tubulin inhibitor 35 (Tubulin IN 35) 是一种有效的拓扑异构酶 I 和微管蛋白聚合的双重抑制剂，具有抗肿瘤活性，对 MGC-803 和 RKO 细胞株的迁移和侵袭有抑制作用，中断细胞周期，诱导凋亡 (apoptosis)。
T9812	Tubulin inhibitor 24	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 24 是一种 tubulin 抑制剂，可以抑制微管蛋白聚合，以浓度依赖性方式诱导细胞周期停滞在 G2/M 期，具有抗肿瘤活性且无明显毒性。
T13224	Tubulin inhibitor 6 iHAP1	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 6 (iHAP1) 是一种微管蛋白抑制剂，抑制微管蛋白聚合，IC50为 0.87 μM。它抑制多种癌细胞系，抑制 K562 细胞生长，IC50为 840 nM。
T67935	Tubulin inhibitor 11	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Tubulin inhibitor 11 是一种口服活性的有效微管蛋白抑制剂。它通过靶向秋水仙碱结合位点，抑制tubulin聚合，进而促进有丝分裂阻断和apoptosis。
T77651	Tubulin polymerization-IN-47	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-47 是一种 tubulin 聚合抑制剂和有丝分裂抑制剂，具有抗肿瘤活性，对神经母细胞瘤癌细胞增殖具有抑制作用，对 Chp-134 和 Kelly 细胞系的IC50 分别为 7 和 12 nM。Tubulin polymerization-IN-47 是治疗肝癌、结肠癌、肺癌和乳腺癌的候选化合物。
T13226	Tubulin inhibitor 8	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 8是管蛋白和多种癌症细胞系的抑制剂，对管蛋白聚合和K562细胞生长具有抑制作用，IC50分别为0.73μM 和14nM。
T77647	Tubulin polymerization-IN-43	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Tubulin polymerization-IN-43 是一种微管蛋白聚合 (tubulin polymerization) 抑制剂。Tubulin polymerization-IN-43 具有多种作用，通过靶向 Colchicine 位点破坏细胞微管网络，促进白血病细胞的细胞周期停滞在 G2/M 期和细胞凋亡 (apoptosis)。Tubulin polymerization-IN-43 具有抗血管生成活性。
T78701	Tubulin inhibitor 32	Apoptosis	Apoptosis
	Tubulin inhibitor 32是一种口服活性的新型微管抑制剂，具有抗增殖和抗肿瘤活性，可抑制微管聚合，可诱导细胞凋亡及在G2/M期引起细胞周期停滞。
T77728	Tubulin polymerization-IN-55	Microtubule Associated	Cytoskeletal Signaling
	Tubulin polymerization-IN-55 是一种高效的 Tubulin Polymerization 抑制剂，具有潜在的抗血管生成和抗肿瘤活性，对 A549、K562、HepG2、MDA-MB-231 和 HFL-1 显示出抗增殖作用。
T13225	Tubulin inhibitor 7	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 7 is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines (tubulin polymerization (IC50: 0.52 μM), K562 cell growth (IC50: 11 nM)).
T13227	Tubulin inhibitor 1	Microtubule Associated	Cytoskeletal Signaling
	Tubulin inhibitor 1 is an inhibitor of tubulin, inhibits tubulin polymerization, with potent anti-tumor activity, induces cellular apoptosis causes and cellular mitotic arrest in the G2/M phase.
T61472	Tubulin inhibitor 18	Others	Others
	Tubulin inhibitor 18 (compound 5j) is a highly potent chalcone compound that effectively inhibits tubulin. Its unique molecular structure renders Tubulin inhibitor 18 as a promising candidate for cancer research [1].
T72445	Tubulin inhibitor 30	Others	Others
	Tubulin inhibitor 30 是一种 tubulin 组合抑制剂，IC50为 0.52 μM。Tubulin inhibitor 30 可以诱导 ferroptosis。
T62445	Tubulin inhibitor 22	Others	Others
	Tubulin inhibitor 22 (compound 4c) 是一种 tubulin 的有效抑制剂，表现出抗血管生成和抗癌活性。Tubulin inhibitor 22 能够将 MGC-803 细胞的细胞周期阻滞在 G2/M 期。Tubulin inhibitor 22 剂量依赖性地通过线粒体功能障碍引起 Caspase 诱导的 MGC-803 细胞凋亡 (apoptosis)。
T60026	KIF18A-IN-2	Microtubule Associated	Cytoskeletal Signaling
	KIF18A-IN-2 是有丝分裂驱动蛋白 Kif18A 的抑制剂，IC50 为 28 nM，可用于染色体不稳定性相关漏洞的研究。
T60459	Tubulin inhibitor 15	Others	Others
	Tubulin inhibitor 15 是有效的微管蛋白抑制剂，具有抗增殖活性。Tubulin inhibitor 15 在 HepG2 细胞中表现出细胞毒性。
T60460	Tubulin inhibitor 16	Others	Others
	Tubulin inhibitor 16 是有效的微管蛋白抑制剂，具有抗增殖活性。Tubulin inhibitor 16 在 HepG2 细胞中表现出细胞毒性。
T62922	Tubulin inhibitor 25	Others	Others
	Tubulin inhibitor 25 是一种微管蛋白 (tubulin) 的有效抑制剂 (IC50: 0.98 μM)，能够显著抑制 HT29 细胞。Tubulin inhibitor 25 对细胞迁移和微管形成具有抑制作用，有助于抗血管生成。
T62332	Tubulin inhibitor 13	Others	Others
	Tubulin inhibitor 13 (E27) 是一种有效的tubulin抑制剂，其对tubulin聚合的抑制IC50值为16.1 μM。该化合物不仅可以抑制癌细胞迁移和侵袭，还能诱导apoptosis，显示出抗癌活性。
T78761	Tubulin inhibitor 34	Others	Others
	Tubulin inhibitor 34 (compound b5) 为抗癌效果显著之化学药物，能够阻断微管蛋白（tubulin）聚合，促使G2/M期细胞周期停滞及细胞凋亡（apoptosis），并展现出明显的抗血管生成与抗肿瘤活性。
T72449	Tubulin inhibitor 31	Others	Others
	Tubulin inhibitor 31, 以IC50值4 µM的效力，是一种高效的微管蛋白(Tubulin)抑制剂，具有显著的抗增殖活性，并能抑制HUVEC的迁移。
T61545	Tubulin inhibitor 28	Others	Others
	Tubulin inhibitor 28 (compound 2g) 是一种有效的微管抑制剂，IC50值为 1.2 μM。Tubulin inhibitor 28 对 MCF-7 细胞具有抗增殖活性。
T60793	Tubulin inhibitor 26	Others	Others
	Tubulin inhibitor 26 (compound 3c) 是一种吲唑衍生物，是微管蛋白抑制剂，对 HepG2、HCT116、SW620、HT29 和 A549 癌细胞系具有显著的低纳摩尔效力。Tubulin inhibitor 26 抑制G2/M 期肿瘤细胞，并且诱导细胞凋亡。Tubulin inhibitor 26 在体内抑制肿瘤生长，并且不影响小鼠体重。
T61242	Tubulin inhibitor 12	Others	Others
	Tubulin inhibitor 12 (Hit 9) is a recently developed compound with potent inhibitory effects on tubulin (IC50 = 25.3 μM). This compound exhibits noteworthy anti-tumor and anti-proliferative activities, making it a promising candidate for the treatment of cancer [1].
T73832	Tubulin inhibitor 21	Others	Others
	Tubulin inhibitor 21 (compound 6f) 为基于查尔酮与褪黑激素混合的有效tubulin抑制剂。该化合物对SW480细胞展现显著的细胞毒性活性（IC50=0.26 μM），对非恶性细胞的毒性较低。
T78772	Tubulin inhibitor 37	Others	Others
	Tubulin inhibitor 37（化合物 12）作为Tubulin抑制剂，对Tubulin聚合表现出显著的抑制作用（IC50=1.3 µM）。此外，该化合物在人肿瘤细胞系上展现抗增殖潜力，因此对癌症研究颇具价值。
T60402	Tubulin inhibitor 14	Others	Others
	Tubulin inhibitor 14 是一种有效的 NQO2（醌氧化还原酶 2）抑制剂，IC50 为 1.0 μM，也抑制微管蛋白聚合和内皮细胞毛细管样管的形成。Tubulin inhibitor 14 是一种微管去稳定剂，具有潜在的肿瘤选择性以及抗血管生成和血管破坏的功能[1]。
T78917	Tubulin inhibitor 33	Others	Others
	Tubulin inhibitor 33为一种抗微管蛋白聚合化合物，其抑制作用表现为剂量依赖性，具有9.05 μM的IC50。该化合物不仅具备抗肿瘤活性，还能诱导细胞凋亡(apoptosis)，在抗肿瘤研究领域有应用潜力。
T78771	Tubulin inhibitor 36	Others	Others
	Tubulin inhibitor 36 (Compound 10) 是新型高效微管蛋白抑制剂，可阻止微管蛋白聚合并诱发细胞凋亡，IC50值为1.5±0.1 μM。该化合物在抗有丝分裂中表现出显著活性，并对胶质母细胞瘤（GBM）细胞线有效，适用于胶质母细胞瘤（GBM）的抗肿瘤研究。
T78773	Tubulin inhibitor 38	Others	Others
	Tubulin inhibitor 38（化合物14）是一款强效的四唑基微管蛋白抑制剂，能够显著抑制细胞增殖。以100 nM浓度作用24小时后，该抑制剂能够引起有丝分裂停滞，特别是在G2/M期细胞周期阶段，进而诱导细胞凋亡。在HeLa、MCF7和U87 MG细胞系中，Tubulin inhibitor 38展现了较高的细胞毒性及选择性。
T15236	Entasobulin	Microtubule Associated	Cytoskeletal Signaling
	Entasobulin 是一种 β-微管蛋白聚合的抑制剂，具有潜在的抗癌活性。
T62498	Tubulin polymerization-IN-20	Others	Others
	Tubulin aggregation-IN-20 (compound 11) 是一种有效的 tubulin 聚合抑制剂。Tubulin aggregation-IN-20 具有潜力进行乳腺癌和耐药结肠癌的研究。
T63836	Tubulin polymerization-IN-7	Others	Others
	Tubulin aggregation-IN-7 是有效的 tubulin 聚合抑制剂，对癌症疾病表现出研究潜力。
T61084	Tubulin polymerization-IN-37	Others	Others
	Tubulin polymerization-IN-37 is a potent inhibitor (IC50: 2.3 μΜ) of tubulin polymerization by binding specifically to the colchicine site of tubulin and preventing colchicine binding. It has potential applications in cancer research, notably for lymphomas [1].
T62971	Tubulin polymerization-IN-16	Others	Others
	Tubulin aggregation-IN-16 (compound 5g) 是一种有效的 tubulin 聚合抑制剂。Tubulin aggregation-IN-16 对癌细胞有效 (IC50: 0.084-0.221 μM)。Tubulin aggregation-IN-16 能有效地破坏微管/管蛋白的动态，诱导 SGC-7901 细胞的细胞周期阻滞在 G2/M 期。
T62206	Tubulin polymerization-IN-19	Others	Others
	Tubulin aggregation-IN-19 (compound 4) 是一种有效 tubulin 聚合抑制剂，对乳腺癌和耐药结肠癌表现出研究潜力。
T61524	Tubulin/HDAC-IN-1	Others	Others
	Tubulin/HDAC-IN-1 is a compound that functions as a dual inhibitor for tubulin and HDAC-IN-1. It achieves this by interacting with tubulin through CH/π interaction and with HDAC8 through hydrogen bond interaction. This compound effectively inhibits tubulin polymerization and selectively targets HDAC8 with an IC50 of 150 nM. Additionally, Tubulin/HDAC-IN-1 demonstrates cytotoxicity against various human cancer cells, induces cell cycle arrest in the G2/M phase, and triggers cell apoptosis. This c...
T79887	Tubulin polymerization-IN-49	Others	Others
	Tubulin polymerization-IN-49 (compound 12d) 是一种抑制微管蛋白聚合的有效化合物。它通过结合到微管蛋白的秋水仙碱位点来抑制其聚合。此外，Tubulin polymerization-IN-49 能够诱导细胞周期在 G2/M 期停滞并触发细胞凋亡，表现出对抗癌的活性，能够预防肿瘤的生成及抑制肿瘤增殖和血管生成。
T62121	Tubulin polymerization-IN-3	Others	Others
	Tubulin polymerization-IN-3 是一种有效的微管蛋白聚合抑制剂 (IC50: 3.84 μM)，能够诱导结肠癌细胞凋亡。
T63120	Tubulin inhibitor 23	Others	Others
	Tubulin inhibitor 23 是一种 Tubulin 的有效抑制剂 (IC50: 4.8 μM)。Tubulin inhibitor 23 以剂量依赖性方式表现出抗血管生成作用，并可诱导细胞凋亡。Tubulin inhibitor 23 具有潜力进行白血病的研究。
T60436	Tubulin inhibitor 17	Others	Others
	Tubulin inhibitor 17 (Compound 3b) 是微管蛋白聚合抑制剂（IC50 = 12.38 μM）。Tubulin inhibitor 17 显示出抗癌活性并且诱导细胞凋亡。
T60755	Tubulin inhibitor 20	Others	Others
	Tubulin inhibitor 20 (compound 1) 作为tubulin 的有效抑制剂，显示出癌症研究的潜力。
T61190	Tubulin inhibitor 27	Others	Others
	Tubulin inhibitor 27 (DYT-1) 是一种微管蛋白聚集 (tubulin polymerisation) 抑制剂，IC50为 25.6 μM。Tubulin inhibitor 27 具有抗血管生成活性和抗肿瘤活性。
T60568	Tubulin inhibitor 29	Others	Others
	Tubulin inhibitor 29 (compound 3c) 是一种有效的微管抑制剂，可抑制微管聚合并与秋水仙碱位点结合 (IC 50 = 1.2 μM)。Tubulin inhibitor 29 具有抗增殖作用，对人乳腺癌细胞 MCF-7 细胞的 IC50值为 7.5 μM。
T61459	Tubulin inhibitor 19	Others	Others
	Tubulin inhibitor 19 (compound 9b) is a potent indole chalcone compound that exhibits strong inhibitory activity against tubulin. Its potential in cancer research makes it valuable for studying cancer diseases [1].
T62058	αβ-Tubulin-IN-1	Others	Others
	αβ-Tubulin-IN-1 是有效且具有口服活性的αβ-Tubulin 抑制剂。αβ-Tubulin-IN-1 将细胞周期阻滞在 G2/M 期并诱导细胞凋亡 (apoptosis)。αβ-Tubulin-IN-1 抑制肿瘤细胞迁移和转移。αβ-Tubulin-IN-1 具有显著的抗肿瘤功效。
T62369	Tubulin polymerization-IN-17	Others	Others
	Tubulin aggregation-IN-17 (compound 23g) 是一种 tubulin 聚合的有效抑制剂。Tubulin aggregation-IN-17 具有微管蛋白解聚作用，能够诱导细胞凋亡并抑制迁移。Tubulin aggregation-IN-17 具有潜力进行癌症疾病的研究。
T61940	Tubulin polymerization-IN-4	Others	Others
	Tubulin polymerization-IN-4 是有效的微管蛋白聚合体 (tubulin polymerization) 抑制剂（IC50=4.6 μM）。Tubulin polymerization-IN-4 可以破坏微管蛋白聚合，将细胞周期阻滞在G2/M 期，诱导细胞凋亡 (apoptosis)，抑制细胞的克隆发生和迁移。Tubulin polymerization-IN-4还可以破坏血管系统。
T60735	Tubulin polymerization-IN-22	Others	Others
	Tubulin aggregation-IN-22 抑制细胞周期在 G2/M 期，并且诱导细胞凋亡。Tubulin aggregation-IN-22 是一种微管蛋白聚合抑制剂 (IC50 = 8.1 μM)。
T60936	Tubulin polymerization-IN-24	Others	Others
	Tubulin aggregation-IN-24 (compound HMBA) 是一种有效的微管蛋白聚合抑制剂，可提高 GTP 水解速率并抑制微管组装。Tubulin aggregation-IN-24 诱导细胞凋亡和细胞周期停滞在 G2/M 期。Tubulin aggregation-IN-24 抑制乳腺癌细胞 MCF-7 的增殖。

化合物

Tubulin inhibitor 35

Cat.No: T77584

Synonym: Tubulin IN 35

Target: Apoptosis, Microtubule Associated, Topoisomerase

Tubulin inhibitor 24

Cat.No: T9812

Target: Microtubule Associated

Tubulin inhibitor 6

Cat.No: T13224

Synonym: iHAP1

Target: Microtubule Associated

Tubulin inhibitor 11

Cat.No: T67935

Target: Apoptosis, Microtubule Associated

Tubulin polymerization-IN-47

Cat.No: T77651

Target: Microtubule Associated

Tubulin inhibitor 8

Cat.No: T13226

Target: Microtubule Associated

Tubulin polymerization-IN-43

Cat.No: T77647

Target: Apoptosis, Microtubule Associated

Tubulin inhibitor 32

Cat.No: T78701

Target: Apoptosis

Tubulin polymerization-IN-55

Cat.No: T77728

Target: Microtubule Associated

Tubulin inhibitor 7

Cat.No: T13225

Target: Microtubule Associated

Tubulin inhibitor 1

Cat.No: T13227

Target: Microtubule Associated

Tubulin inhibitor 18

Cat.No: T61472

Target: Others

Tubulin inhibitor 30

Cat.No: T72445

Target: Others

Tubulin inhibitor 22

Cat.No: T62445

Target: Others

Cat.No: T60026

Target: Microtubule Associated

Tubulin inhibitor 15

Cat.No: T60459

Target: Others

Tubulin inhibitor 16

Cat.No: T60460

Target: Others

Tubulin inhibitor 25

Cat.No: T62922

Target: Others

Tubulin inhibitor 13

Cat.No: T62332

Target: Others

Tubulin inhibitor 34

Cat.No: T78761

Target: Others

Tubulin inhibitor 31

Cat.No: T72449

Target: Others

Tubulin inhibitor 28

Cat.No: T61545

Target: Others

Tubulin inhibitor 26

Cat.No: T60793

Target: Others

Tubulin inhibitor 12

Cat.No: T61242

Target: Others

Tubulin inhibitor 21

Cat.No: T73832

Target: Others

Tubulin inhibitor 37

Cat.No: T78772

Target: Others

Tubulin inhibitor 14

Cat.No: T60402

Target: Others

Tubulin inhibitor 33

Cat.No: T78917

Target: Others

Tubulin inhibitor 36

Cat.No: T78771

Target: Others

Tubulin inhibitor 38

Cat.No: T78773

Target: Others

Cat.No: T15236

Target: Microtubule Associated

Tubulin polymerization-IN-20

Cat.No: T62498

Target: Others

Tubulin polymerization-IN-7

Cat.No: T63836

Target: Others

Tubulin polymerization-IN-37

Cat.No: T61084

Target: Others

Tubulin polymerization-IN-16

Cat.No: T62971

Target: Others

Tubulin polymerization-IN-19

Cat.No: T62206

Target: Others

Tubulin/HDAC-IN-1

Cat.No: T61524

Target: Others

Tubulin polymerization-IN-49

Cat.No: T79887

Target: Others

Tubulin polymerization-IN-3

Cat.No: T62121

Target: Others

Tubulin inhibitor 23

Cat.No: T63120

Target: Others

Tubulin inhibitor 17

Cat.No: T60436

Target: Others

Tubulin inhibitor 20

Cat.No: T60755

Target: Others

Tubulin inhibitor 27

Cat.No: T61190

Target: Others

Tubulin inhibitor 29

Cat.No: T60568

Target: Others

Tubulin inhibitor 19

Cat.No: T61459

Target: Others

αβ-Tubulin-IN-1

Cat.No: T62058

Target: Others

Tubulin polymerization-IN-17

Cat.No: T62369

Target: Others

Tubulin polymerization-IN-4

Cat.No: T61940

Target: Others

Tubulin polymerization-IN-22

Cat.No: T60735

Target: Others

Tubulin polymerization-IN-24

Cat.No: T60936

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T2773	Vindoline 文朵灵,文多灵	Microtubule Associated	Cytoskeletal Signaling
	Vindoline 是从长春花叶片中提取的一种生物碱，通过抑制微管组装而表现出抗有丝分裂活性。
T36850	Curvulin	Microtubule Associated	Cytoskeletal Signaling
	Curvulin 是一种植物毒素，可以抑制微管组装，也可以抑制 iNOS 的表达。
T8188	Podophyllotoxone	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	Podophyllotoxone 是从八角莲根中分离得到的一种天然产物，能抑制微管蛋白聚合，具有抗癌活性。
T3S0209	Vincristine	ERK; p38 MAPK; NF-κB; Akt; JNK; mTOR	Cytoskeletal Signaling; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Vincristine 属于生物碱类天然产物，可与微管蛋白结合并抑制微管的形成，从而抑制肿瘤细胞的有丝分裂。Vincristine 可用作微管去稳定剂，用于研究治疗血液系统肿瘤，如白血病和淋巴瘤以及儿童肉瘤的相关研究。
T1121	Podofilox 鬼臼毒素,Podophyllotoxin,(+)-Shikonin	Microtubule Associated; Topoisomerase	Cytoskeletal Signaling; DNA Damage/DNA Repair
	Podofilox ((+)-Shikonin) 是从八角莲中分离的一种木脂素，是微管组装和 DNA 拓扑异构酶 II 抑制剂。它对皮肤和粘膜有很强的刺激性，具有角质溶解作用，可用于治疗疣和角化病，具有潜在的抗肿瘤特性。
TN2256	Taccalonolide B 根薯酮内酯B,根薯酮内酯 B	Microtubule Associated	Cytoskeletal Signaling
	Taccalonolide B 是从广西裂果薯中分离得到的一种微管稳定剂，具有抗肿瘤活性。它抑制 SK-OV-3 细胞的生长，IC50 为 208 nM，在体外对过表达 P-糖蛋白 (Pgp) 和多药耐药蛋白 (MRP7) 的细胞系有效。
TN2190	Scoulerine	Apoptosis; Beta-Secretase; BACE; Parasite	Apoptosis; Microbiology/Virology; Neuroscience
	Scoulerine 是抗有丝分裂化合物。它抑制细胞增殖，阻止细胞周期，并诱导癌细胞凋亡。它也是BACE1(淀粉样前体蛋白裂解酶 1) 的抑制剂。
TN2254	Taccalonolide A 根薯酮内酯A,根薯酮内酯 A	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Taccalonolide A 是从水田七根茎中分离得到的一种类固醇，具有细胞毒性和抗疟活性。它在体外对过表达 p 糖蛋白、多药耐药蛋白 7 细胞系有抑制作用，抑制 SK-OV-3 细胞生长的 IC50值为 622 nM。它是微管稳定剂，能引起 G2-M 期滞留、Bcl-2 磷酸化，并引发细胞凋亡。
TN1087	Deoxypodophyllotoxin 脱氧鬼臼毒素,去氧鬼臼毒素	Apoptosis; Microtubule Associated; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Deoxypodophyllotoxin 是从桃儿七根茎分离的一种木酚素，是鬼臼毒素衍生物，具有抗有丝分裂和抗病毒特性。它是血管生成抑制剂，作为靶向微管药物，在肿瘤学中具有重大影响。它引起 DRG 神经元细胞内 Ca2+浓度增加，诱导细胞自噬和凋亡。
T0320	Colchicine 秋水仙碱,秋水仙素,Colcin,Colchineos,Colchisol	Apoptosis; Microtubule Associated; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Colchicine (Colcin) 属于天然产物，是一种微管聚合的抑制剂 (IC50=3 nM)，通过与微管蛋白结合来阻断微管的聚合。Colchicine 可以被用于治疗通风和风湿病。
T6490	Epothilone A 埃博霉素 A,epothile,Epo A	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Epothilone A (Epo A) 是紫杉醇和管蛋白聚合物结合的一种竞争性抑制剂，其Ki 值为 0.6-1.4 μM。
T2217	Cephalomannine Baccatin III,三尖杉宁碱	Microtubule Associated	Cytoskeletal Signaling
	Cephalomannine (Baccatin III) 是一种从云南红豆杉中提取的紫杉醇衍生物，具有抗肿瘤活性，可用于癌症研究。
T16016	Maytansinol 美登醇,Ansamitocin P-0	Apoptosis; Microtubule Associated; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Apoptosis; Cytoskeletal Signaling
	Maytansinol (Ansamitocin P-0) 在体外抑制微管组装并导致微管分解。它与辐射联用，用于果蝇和人类癌细胞。
T0968	Paclitaxel Taxol,紫杉醇,NSC 125973	Apoptosis; Microtubule Associated; Autophagy; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Apoptosis; Autophagy; Cytoskeletal Signaling
	Paclitaxel (Taxol) 属于天然产物，是一种微管聚合物稳定剂。Paclitaxel 具有抗肿瘤活性；通过诱导有丝分裂停滞、细胞凋亡、细胞自噬等，导致细胞死亡。
T3S2372	7-epi-Taxol 7-Epitaxol,7-表紫杉醇,7-epi-Paclitaxel	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	7-epi-Taxol (7-Epitaxol) 是在细胞中发现的紫杉醇的主要衍生物，在抑制细胞增殖、微管解离和诱导微管聚合等方面与紫杉醇作用相当。
T6272	Fosbretabulin Disodium Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Fosbretabulin Disodium (CA 4P) 是一种微管蛋白去稳定剂，是 Combretastatin A4 前药，可选择性靶向内皮细胞，诱导新生肿瘤新血管消退，减少肿瘤血流量并引起中央肿瘤坏死。
T1668	Vinblastine sulfate 硫酸长春碱,NSC49842,Vincaleukoblastine sulfate salt	Microtubule Associated; AChR; Autophagy	Autophagy; Cytoskeletal Signaling; Neuroscience
	Vinblastine sulfate (Vincaleukoblastine sulfate salt) 是对各种癌症类型有细胞毒性的生物碱。它可以抑制微管的形成，也可以抑制 nAChR，IC50值为8.9 μM。
T21351	Maytansine NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine,美坦新	Microtubule Associated; Antibiotic	Cytoskeletal Signaling; Microbiology/Virology
	Maytansine (NSC-153858) 是从变叶美登木中分离的一种高效微管靶向天然产物，可诱导有丝分裂阻滞并在亚纳摩尔浓度杀死肿瘤细胞。
T1270	Vincristine sulfate Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate,硫酸长春新碱	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Vincristine sulfate (Leurocristine sulfate) 是一种抗肿瘤长春花生物碱。在细胞周期的 S 期不可逆地与微管(Ki: 85 nM) 和纺锤体蛋白结合，并干扰有丝分裂纺锤体的形成。
T19720	Colcemid C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine	Microtubule Associated	Cytoskeletal Signaling
	Colcemid (NSC-3096) 是一种微管聚合抑制剂，可诱导细胞凋亡，可用于肿瘤和胚胎克隆的研究。
T1034	Docetaxel 多西他赛,NSC 628503,RP-56976,多烯紫杉醇	Apoptosis; Microtubule Associated; Endogenous Metabolite	Apoptosis; Cytoskeletal Signaling; Metabolism
	Docetaxel (RP-56976) 是紫杉醇的半合成类似物，是一种微管解聚抑制剂 (IC50=0.2 μM)。Docetaxel 可以减弱 bcl-2 和 bcl-xL 基因表达的影响，具有诱导凋亡、抗肿瘤活性。
TP1180	Dolastatin 10 尾海兔素10,NSC 376128,DLS 10	Microtubule Associated; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling
	Dolastatin 10 (DLS 10) 是一种多肽，可以抑制微管蛋白聚合，显示除抗有丝分裂的活性。
T2220	2-Methoxyestradiol 2-甲氧雌二醇,二甲氧基雌二醇,NSC-659853,2-MeOE2,2-ME2	Apoptosis; Reactive Oxygen Species; Microtubule Associated; Endogenous Metabolite; HIF; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
	2-Methoxyestradiol (2-ME2) 是一种口服生物可利用的雌二醇代谢物，具有抗肿瘤活性。它通过减少内皮细胞增殖和诱导内皮细胞凋亡来抑制血管生成，也可破坏微管的稳定。它可诱导半胱天冬酶活化，导致细胞周期停滞在 G2 期、DNA 断裂和细胞凋亡。
T6212	Combretastatin A4 CA4,康普瑞汀,Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯,CRC 87-09	Microtubule Associated	Cytoskeletal Signaling
	Combretastatin A4 (CA4) 是一种微管靶向剂，可结合 β-tubulin，Kd 值为 0.4 μM。
T22455	Vindesine sulfate DVA,Desacetylvinblastine amide,硫酸长春地辛,DAVA,Desacetyl Vinblastine amide,VDS	Others	Others
	Vindesine sulfate (Desacetyl Vinblastine amide) 是一种长春花生物碱，它是长春碱的合成衍生物，与有丝分裂纺锤体的微管蛋白结合，导致微管结晶和有丝分裂停滞或细胞死亡。
T0186	Docetaxel trihydrate RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物	Apoptosis; BCL; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Docetaxel trihydrate (RP-56976 Trihydrate) 是一种抗肿瘤试剂，抑制微管解聚的IC50值为 0.2 μM。它是紫杉醇的半合成类似物，能减弱 bcl-2 和 bcl-xL 基因表达的影响。它阻滞G2/M 细胞周期，导致细胞凋亡。
T1152	Albendazole SKF-62979,阿苯达唑	HIF/HIF Prolyl-Hydroxylase; Microtubule Associated; Antibiotic; Parasite	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Microbiology/Virology
	Albendazole (SKF-62979) 是一种广谱抗寄生虫剂，具有高效，低宿主毒性的特点。它用于研究人类和动物的胃肠道寄生虫。
T4036	Solasodine Solancarpidine,Purapuridine,澳洲茄铵,Solasodin	Apoptosis; Others; E1/E2/E3 Enzyme; Antifungal	Apoptosis; Microbiology/Virology; Others; Ubiquitination
	Solasodine (Purapuridine) 是存在于茄科植物中的一种类固醇生物碱。它具有神经保护、降压、抗真菌、抗癌、抗动脉粥样硬化、抗雄激素和抗炎活性。
T2937	4'-Demethylepipodophyllotoxin 4'-DMEP,4-Demethylepipodophyllotoxin,4'-脱甲基表鬼臼毒素,4'-去甲基表鬼臼毒素,DMEP,4'-O-demethylepipodophyllotoxin	Microtubule Associated	Cytoskeletal Signaling
	4'-Demethylepipodophyllotoxin (DMEP) 是一种有效的微管组装抑制剂。
T2543	Cabazitaxel XRP6258,卡巴他塞,RPR-116258A,TXD 258,taxoid XRP6258	Microtubule Associated; Autophagy	Autophagy; Cytoskeletal Signaling
	Cabazitaxel (taxoid XRP6258) 是一种紫杉烷类的抗肿瘤剂，可用于治疗多西他赛失败后的去势抵抗性转移性前列腺癌。
T5165	10-Deacetyltaxol 10-DAT,10-Desacetyl Paclitaxel,去乙酰紫衫醇,Deacetyltaxol,10-去乙酰紫杉醇,10-deacetyl-paclitaxel,Deacetyl Paclitaxel	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	10-Deacetyltaxol (10-DAT) 是从红豆杉中分离得到的一种紫杉醇衍生物，对人脑胶质细胞瘤和神经母细胞瘤细胞具有细胞毒性。它能促进微管蛋白的聚合，在体外抑制由钙离子诱导的微管解聚。
T6213	Vinorelbine ditartrate Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate,长春瑞滨酒石酸盐,酒石酸长春瑞滨	Microtubule Associated; Autophagy	Autophagy; Cytoskeletal Signaling
	Vinorelbine ditartrate (KW-2307)是一种抗有丝分裂剂，能够抑制 Hela 细胞的增殖，IC50值为 1.25 nM。
T5749	10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside	Others; Microtubule Associated; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling; Others
	10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) 是一种紫杉醇衍生物，具有改进的药理特性和更高的水溶性，用于治疗癌症。
TN6706	3-demethylcolchicine 3-去甲秋水仙碱,3-去甲基秋水仙碱	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	3-Demethylcolchicine 是一种从金莲花中分离得到的天然产物，对纯化的牛脑微管蛋白的聚合有抑制作用。
T22262	Ansamitocin p-3 Maytansinol isobutyrate,Antibiotic C 15003P3,NSC292222	Microtubule Associated; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling
	Ansamitocin p-3 (Maytansinol isobutyrate) 是一种微管抑制剂，对微管蛋白聚合的 IC50 为 3.4 μM。
T0190	Vinorelbine 长春瑞宾,KW-2307 base	Microtubule Associated	Cytoskeletal Signaling
	Vinorelbine (KW-2307 base) 是一种半合成的长春花生物碱。它与微管蛋白结合并阻止有丝分裂纺锤体的形成，导致中期肿瘤细胞生长停滞。
T13653	Dihydrocephalomannine	Others	Others
	Dihydrocephalomannine is similar to paclitaxel, showing reduced cytotoxicity and tubulin binding.
T28428	PM-060184 Plocabulin,PM 060184	Others	Others
	PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.
TN5107	Taxcultine	Others	Others
	Taxcultine can actively promote tubulin assembly.
T82241	Halichondrin B
	Halichondrin B，源自海绵 Halichondria okadai，为非竞争性Vinca-alkaloid 微管蛋白结合抑制剂，微管蛋白聚合 IC50 值为1.2-1.4 μM，表现出抗肿瘤活性。
T75646	Moroidin	Others	Others
	Moroidin是一种双环八肽，隶属于荨麻疹科环肽科，有效抑制纯化的微管蛋白聚合，表现为微管蛋白聚合抑制剂。此外，Moroidin对包括A549人肺癌细胞在内的多种癌细胞显示出细胞毒性作用，能诱导细胞凋亡。
T75521	PM050489	Others	Others
	PM050489 是一种有效的聚酮类微管/微管蛋白 (Microtubule/Tubulin) 抑制剂，可从马达加斯加海绵Lithoplocamia lithistoides 中分离。PM050489 抑制有丝分裂，IC50值为 26.4 nM。PM050489 具有抗肿瘤活性，能用于癌症研究。
T13944	Tubulysin M	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Tubulysin M is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin M is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T13941	Tubulysin G	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Tubulysin G is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin G is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T82787	Calythropsin
	Calythropsin是一种对有丝分裂产生微弱影响的细胞毒性查尔酮类化合物，该化合物可能还会影响微管蛋白的聚合。
T82857	Blestriarene B (-)-Blestriarene B
	(-)-Blestriarene B 是一种从白芨（兰科）中分离得到的二苯乙烯类化合物，其通过抑制微管蛋白的聚合作用发挥效用。
T13940	Tubulysin F	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Tubulysin F is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin F is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T13943	Tubulysin I	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Tubulysin I is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin I is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to c
T13942	Tubulysin H	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	Tubulysin H is a natural product isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and is a highly cytotoxic peptide. Tubulysin H is a cytotoxic activity tubulysin that inhibits tubulin polymerization and leads to ce
T13228	Tubulysin D	Microtubule Associated; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Cytoskeletal Signaling
	Tubulysin D is a tetrapeptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis, and displays potent antitumor activity.
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天然产物

Cat.No: T2773

Synonym: 文朵灵,文多灵

Target: Microtubule Associated

Cat.No: T36850

Target: Microtubule Associated

Podophyllotoxone

Cat.No: T8188

Target: Others, Microtubule Associated

Cat.No: T3S0209

Target: ERK, p38 MAPK, NF-κB, Akt, JNK, mTOR

Cat.No: T1121

Synonym: 鬼臼毒素,Podophyllotoxin,(+)-Shikonin

Target: Microtubule Associated, Topoisomerase

Taccalonolide B

Cat.No: TN2256

Synonym: 根薯酮内酯B,根薯酮内酯 B

Target: Microtubule Associated

Cat.No: TN2190

Target: Apoptosis, Beta-Secretase, BACE, Parasite

Taccalonolide A

Cat.No: TN2254

Synonym: 根薯酮内酯A,根薯酮内酯 A

Target: Apoptosis, Microtubule Associated

Deoxypodophyllotoxin

Cat.No: TN1087

Synonym: 脱氧鬼臼毒素,去氧鬼臼毒素

Target: Apoptosis, Microtubule Associated, Autophagy

Cat.No: T0320

Synonym: 秋水仙碱,秋水仙素,Colcin,Colchineos,Colchisol

Target: Apoptosis, Microtubule Associated, Autophagy

Cat.No: T6490

Synonym: 埃博霉素 A,epothile,Epo A

Target: Apoptosis, Microtubule Associated

Cat.No: T2217

Synonym: Baccatin III,三尖杉宁碱

Target: Microtubule Associated

Cat.No: T16016

Synonym: 美登醇,Ansamitocin P-0

Target: Apoptosis, Microtubule Associated, ADC Cytotoxin

Cat.No: T0968

Synonym: Taxol,紫杉醇,NSC 125973

Target: Apoptosis, Microtubule Associated, Autophagy, ADC Cytotoxin

Cat.No: T3S2372

Synonym: 7-Epitaxol,7-表紫杉醇,7-epi-Paclitaxel

Target: Others, Microtubule Associated

Fosbretabulin Disodium

Cat.No: T6272

Synonym: Combretastatin A4 Phosphate,CA 4DP,CA 4P,福他布林,Combretastatin A4 disodium phosphate,Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium

Target: Apoptosis, Microtubule Associated

Vinblastine sulfate

Cat.No: T1668

Synonym: 硫酸长春碱,NSC49842,Vincaleukoblastine sulfate salt

Target: Microtubule Associated, AChR, Autophagy

Cat.No: T21351

Synonym: NSC-153858,NSC153858,Maitansina,NSC 153858,Maitansine,美坦新

Target: Microtubule Associated, Antibiotic

Vincristine sulfate

Cat.No: T1270

Synonym: Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate,硫酸长春新碱

Target: Apoptosis, Microtubule Associated

Cat.No: T19720

Synonym: C 12669,C-12669,NSC-3096,Kolchicin,C12669,Demecolcine

Target: Microtubule Associated

Cat.No: T1034

Synonym: 多西他赛,NSC 628503,RP-56976,多烯紫杉醇

Target: Apoptosis, Microtubule Associated, Endogenous Metabolite

Cat.No: TP1180

Synonym: 尾海兔素10,NSC 376128,DLS 10

Target: Microtubule Associated, ADC Cytotoxin

2-Methoxyestradiol

Cat.No: T2220

Synonym: 2-甲氧雌二醇,二甲氧基雌二醇,NSC-659853,2-MeOE2,2-ME2

Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated, Endogenous Metabolite, HIF, Autophagy

Combretastatin A4

Cat.No: T6212

Synonym: CA4,康普瑞汀,Z)-3,4,5,4',-四甲氧基-3'-羟基二苯乙烯,CRC 87-09

Target: Microtubule Associated

Vindesine sulfate

Cat.No: T22455

Synonym: DVA,Desacetylvinblastine amide,硫酸长春地辛,DAVA,Desacetyl Vinblastine amide,VDS

Target: Others

Docetaxel trihydrate

Cat.No: T0186

Synonym: RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物

Target: Apoptosis, BCL, Microtubule Associated

Cat.No: T1152

Synonym: SKF-62979,阿苯达唑

Target: HIF/HIF Prolyl-Hydroxylase, Microtubule Associated, Antibiotic, Parasite

Cat.No: T4036

Synonym: Solancarpidine,Purapuridine,澳洲茄铵,Solasodin

Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal

4'-Demethylepipodophyllotoxin

Cat.No: T2937

Synonym: 4'-DMEP,4-Demethylepipodophyllotoxin,4'-脱甲基表鬼臼毒素,4'-去甲基表鬼臼毒素,DMEP,4'-O-demethylepipodophyllotoxin

Target: Microtubule Associated

Cat.No: T2543

Synonym: XRP6258,卡巴他塞,RPR-116258A,TXD 258,taxoid XRP6258

Target: Microtubule Associated, Autophagy

10-Deacetyltaxol

Cat.No: T5165

Synonym: 10-DAT,10-Desacetyl Paclitaxel,去乙酰紫衫醇,Deacetyltaxol,10-去乙酰紫杉醇,10-deacetyl-paclitaxel,Deacetyl Paclitaxel

Target: Others, Microtubule Associated

Vinorelbine ditartrate

Cat.No: T6213

Synonym: Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate,长春瑞滨酒石酸盐,酒石酸长春瑞滨

Target: Microtubule Associated, Autophagy

10-Deacetyl-7-xylosyl paclitaxel

Cat.No: T5749

Synonym: 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside

Target: Others, Microtubule Associated, ADC Cytotoxin

3-demethylcolchicine

Cat.No: TN6706

Synonym: 3-去甲秋水仙碱,3-去甲基秋水仙碱

Target: Reactive Oxygen Species

Ansamitocin p-3

Cat.No: T22262

Synonym: Maytansinol isobutyrate,Antibiotic C 15003P3,NSC292222

Target: Microtubule Associated, ADC Cytotoxin

Cat.No: T0190

Synonym: 长春瑞宾,KW-2307 base

Target: Microtubule Associated

Dihydrocephalomannine

Cat.No: T13653

Target: Others

Cat.No: T28428

Synonym: Plocabulin,PM 060184

Target: Others

Cat.No: TN5107

Target: Others

Cat.No: T82241

Cat.No: T75646

Target: Others

Cat.No: T75521

Target: Others

Cat.No: T13944

Target: Others, ADC Cytotoxin

Cat.No: T13941

Target: Others, ADC Cytotoxin

Cat.No: T82787

Cat.No: T82857

Synonym: (-)-Blestriarene B

Cat.No: T13940

Target: Others, ADC Cytotoxin

Cat.No: T13943

Target: Others, ADC Cytotoxin

Cat.No: T13942

Target: Others, ADC Cytotoxin

Cat.No: T13228

Target: Microtubule Associated, ADC Cytotoxin

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03059	Tubulin cofactor A Protein, Human, Recombinant tubulin folding cofactor A	Human	E. coli
	Tubulin folding cofactor A belongs to the TBCA family. It is one of four proteins (cofactors A, D, E, and C) involved in the early step of the tubulin folding pathway. These proteins can fold intermediates and finally lead to correctly folded beta-tubulin. It is believed that tubulin folding cofactors A and D play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Tubulin folding cofactor E binds to the cofactor D/beta-tubulin complex; interaction with...
TMPH-00383	Tubulin beta-1 chain Protein, Chicken, Recombinant (His) Tubulin beta-1 chain,Beta-tubulin class-I	Chicken	E. coli
	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Tubulin beta-1 chain Protein, Chicken, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 53.3 kDa and the accession number is P09203.
TMPJ-00773	TUBB4A Protein, Human, Recombinant (His) Tubulin β-4A Chain,Tubulin 5 β,TUBB4,TUBB5...	Human	E. coli
	Tubulin Beta-4A Chain (TUBB4A) is a cytoplasmic peptide containing 444 amino acids. TUBB4A is a member of the Tubulin family. Tubulin is the major constituent of microtubules. Tubulin is a dimer composed of one alpha and one beta tubulin molecule; there are many forms of beta tubulins, Beta II and Beta IV Tubulin are ubiquitously expressed. Beta-III Tubulin, also known as Tubulin Beta-4, is regarded as a neuron-specific marker. It binds two moles of GTP, one at an exchangeable site on the beta c...
TMPH-02262	TUBB3 Protein, Human, Recombinant (GST) Tubulin beta-III,Tubulin beta-3 chain,TUBB...	Human	E. coli
	TUBB3 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 50.1 kDa and the accession number is Q13509.
TMPH-02260	TUBB Protein, Human, Recombinant (His) Tubulin beta chain,TUBB,Tubulin beta-5 cha...	Human	E. coli
	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 50.6 kDa and the accession number is P07437.
TMPH-02261	TUBB2A Protein, Human, Recombinant (His) TUBB2A,Tubulin beta-2A chain,Tubulin beta ...	Human	P. pastoris (Yeast)
	Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
TMPH-02180	TTBK2 Protein, Human, Recombinant (His & Myc) Tau-tubulin kinase 2,TTBK2	Human	E. coli
	Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
TMPY-03392	CKAP1/TBCB Protein, Human, Recombinant (His) CKAPI,tubulin folding cofactor B,CG22,CKAP1	Human	E. coli
	Tubulin-folding cofactor B, also known as TBCB, belongs to the TBCB family. It contains 1 CAP-Gly domain and can be detected in most tissues. TBCB binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway. The cytoskeleton is composed of 3 structural elements: actin filaments, microtubules, and intermediate filaments. TBCB is involved in regulation of tubulin heterodimer dissociation. It may function as a negative regulator of axonal growth.
TMPH-01474	HDAC6 Protein, Human, Recombinant (His) Protein deacetylase HDAC6,Histone deacetylase 6,HDAC6,Tu...	Human	E. coli
	HDAC6 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02263	VASH1 Protein, Human, Recombinant (His) Tubulin carboxypeptidase 1,Tubulinyl-Tyr c...	Human	E. coli
	VASH1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.3 kDa and the accession number is Q7L8A9.
TMPY-04110	TPPP2 Protein, Human, Recombinant (His) P18,p25β,CT152,tubulin polymerization-promoting pro...	Human	E. coli
	TPPP2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 20.3 kDa and the accession number is AAH38970.1.
TMPY-03397	TPPP3 Protein, Human, Recombinant (His) CGI-38,TPPP3,p25gamma,tubulin polymerization-promot...	Human	E. coli
	TPPP3, a member of the Tubulin polymerization-promoting protein family, is an intrinsically unstructured protein that induces tubulin polymerization. TPPP3 is a marker in the developing musculoskeletal system. In tendons, Tppp3 is expressed in cells at the circumference of the developing tendons, likely the progenitors of connective tissues that surround tendons: the tendon sheath, epitenon, and paratenon. Tppp3 is also expressed in forming synovial joints. The onset of Tppp3 expression in joint...
TMPY-01203	RP2 Protein, Human, Recombinant (GST) DELXp11.3,RP2,NME10,KIAA0215,NM23-H10,TBCCD2,retinitis pigme...	Human	Baculovirus Insect Cells
	XRP2, also known as Protein XRP2 and RP2, is a member of the TBCC (tubulin cofactor C) family and contains one C-CAP/cofactor C-like domain. This protein is encoded by the RP2 gene in humans. XRP2 stimulates the GTPase activity of tubulin, but does not enhance tubulin heterodimerization. XRP2 acts as guanine nucleotide dissociation inhibitor for ARL3. Defects in RP2 gene are the cause of retinitis pigmentosa type 2 (RP2), also known as X-linked retinitis pigmentosa 2 (XLRP-2). It leads to degene...
TMPJ-00827	Tau-D Protein, Human, Recombinant (His) PHF-Tau,MAPTL,MAPT,Paired Helical Filament-Tau,Microtubule-A...	Human	E. coli
	Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. Tau interacts with tubulin to stabilize microtubules and promotes tubulin assembly into microtubules. The C-terminus of TAU binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau acts as a linker protein. When tau is defective,...
TMPY-03750	CRIPT Protein, Human, Recombinant (His) HSPC139,SSMDF,cysteine-rich PDZ-binding protein	Human	E. coli
	CRIPT, also known as cysteine-rich PDZ-binding protein, belongs to the CRIPT family. It interacts with TUBB1. CRIPT also interacts strongly with the PDZ3 domain of members of the DLG4 family. It is involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. CRIPT is highly conserved from mammals to plants and binds selectively to the third PDZ domain (PDZ3) of PSD-95 via its C terminus. n heterologous cells, CRIPT causes a redistribution of PSD-95 to microtubules. In brain, CRIPT colo...
TMPH-02304	Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO) Vasohibin-2,VASH2,Vasohibin-like protein,Tubulinyl-...	Human	E. coli
	Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation. Vasohibin-2/VASH2 Protein, Human,...
TMPJ-01270	ZMYND19 Protein, Human, Recombinant (His) MCH-R1-Interacting Zinc Finger Protein,Zinc Finger MYND Doma...	Human	E. coli
	Human Zinc Finger MYND Domain-Containing Protein 19 (ZMYND19) is a protein that contains 1 MYND-Type Zinc Finger. ZMYND19 can be expressed by the brain, testis, placenta, heart, liver, skeletal muscle, kidney, and stomach. ZMYND19 interacts with GPR24/MCH-R1. It binds to the C terminus of Melanin-Concentrating Hormone Receptor-1 and the N Termini of α-Tubulin. ZMYND19 may be involved as a regulatory molecule in GPR24/MCH-R1 signaling.
TMPJ-01387	PACSIN2 Protein, Human, Recombinant (His) Protein Kinase C and Casein Kinase Substrate in Neurons Prot...	Human	HEK293 Cells
	Protein Kinase C and Casein Kinase Substrate in Neurons Protein 2 (PACSIN2) is a member of the PACSIN family. PACSIN2 is localized to the plasma membrane via its coiled-coil domain. PACSIN2 is widely expressed and contains one FCH domain and one SH3 domain. PACSIN2 forms homo- and hetero-aggregates with other PACSINs. PACSIN2 may play a role in vesicle formation and transport. In addition, PACSIN2 is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymeri...
TMPH-02183	CCT2 Protein, Human, Recombinant (His & SUMO) CCT2,99D8.1,CCT-beta,TCP-1-beta,CCTB,T-complex protein 1 sub...	Human	E. coli
	Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin. CCT2 Protein, Human, Recombinant (His & S...
TMPY-03047	Stathmin 1 Protein, Human, Recombinant (His) SMN,OP18,stathmin 1,LAP18,C1orf215,PP17,Lag,PP19,PR22	Human	E. coli
	Stathmin1 (STMN1) is a cytosolic phosphoprotein that regulates cellular microtubule dynamics and is known to have oncogenic activity. STMN1 is a possible biomarker for paclitaxel sensitivity and poor prognosis in GC and could be a novel therapeutic target in metastatic GC. STMN1 expression might serve as a biomarker for determining patient atypical meningioma prognosis. Stathmin1 (STMN1) is a cytosolic protein involved in microtubule dynamics through inhibition of tubulin polymerization and prom...
TMPY-03509	TCTP/TPT1 Protein, Human, Recombinant (His) tumor protein, translationally-controlled 1,HRF,TCTP,p23,p02	Human	E. coli
	Tumor protein, also known as TPT1, is a highly conserved protein among many eukaryotic organisms. Tumor protein is involved in a variety of cellular activities, including microtubule stabilization, calcium-binding activities, and apoptosis. The Mammalian translationally controlled tumour protein (TPT1) (or P23) is a protein that has been found to be preferentially synthesised in cells during the early growth phase of some types of tumour, but which is also expressed in normal cells. It was first...

重组蛋白

Tubulin cofactor A Protein, Human, Recombinant

Cat.No: TMPY-03059

Species: Human

Expression System: E. coli

Tubulin beta-1 chain Protein, Chicken, Recombinant (His)

Cat.No: TMPH-00383

Species: Chicken

Expression System: E. coli

TUBB4A Protein, Human, Recombinant (His)

Cat.No: TMPJ-00773

Species: Human

Expression System: E. coli

TUBB3 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02262

Species: Human

Expression System: E. coli

TUBB Protein, Human, Recombinant (His)

Cat.No: TMPH-02260

Species: Human

Expression System: E. coli

TUBB2A Protein, Human, Recombinant (His)

Cat.No: TMPH-02261

Species: Human

Expression System: P. pastoris (Yeast)

TTBK2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02180

Species: Human

Expression System: E. coli

CKAP1/TBCB Protein, Human, Recombinant (His)

Cat.No: TMPY-03392

Species: Human

Expression System: E. coli

HDAC6 Protein, Human, Recombinant (His)

Cat.No: TMPH-01474

Species: Human

Expression System: E. coli

VASH1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02263

Species: Human

Expression System: E. coli

TPPP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04110

Species: Human

Expression System: E. coli

TPPP3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03397

Species: Human

Expression System: E. coli

RP2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-01203

Species: Human

Expression System: Baculovirus Insect Cells

Tau-D Protein, Human, Recombinant (His)

Cat.No: TMPJ-00827

Species: Human

Expression System: E. coli

CRIPT Protein, Human, Recombinant (His)

Cat.No: TMPY-03750

Species: Human

Expression System: E. coli

Vasohibin-2/VASH2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02304

Species: Human

Expression System: E. coli

ZMYND19 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01270

Species: Human

Expression System: E. coli

PACSIN2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01387

Species: Human

Expression System: HEK293 Cells

CCT2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02183

Species: Human

Expression System: E. coli

Stathmin 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03047

Species: Human

Expression System: E. coli

TCTP/TPT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03509

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T10948	MMAE-d8 D8-MMAE,D8-Monomethyl auristatin E	ADC Cytotoxin	Antibody-drug Conjugate/ADC Related
	D8-MMAE (D8-Monomethyl auristatin E) is an effective mitotic inhibitor and tubulin inhibitor, deuterated MMAE.
TMIJ-0195	Colchicine-d6
	Colchicine-d6 是 Colchicine 的氘代化合物。Colchicine 的 CAS 号为 64-86-8。Colchicine 是微管蛋白抑制剂和微管干扰剂，通过与微管蛋白结合来阻断微管的聚合，IC50值为 3 nM。它还是α3甘氨酸受体的竞争性拮抗剂。
T70808	Cabazitaxel-d6
	Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance...
T71055	Albendazole-d7
	Albendazole-d7 is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Alben...

同位素标记化合物

Cat.No: T10948

Synonym: D8-MMAE,D8-Monomethyl auristatin E

Target: ADC Cytotoxin

Cat.No: TMIJ-0195

Cat.No: T70808

Cat.No: T71055

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