Tubulin polymerization-IN-36

Name: Tubulin polymerization-IN-36
Brand: TargetMol
SKU: T60758
Rating: 4.5 (1 reviews)

还可以

产品编号 T60758Cas号 2011784-91-9

Tubulin polymerization-IN-36 可用于癌症研究，例如淋巴癌。Tubulin polymerization-IN-36 结合微管蛋白的秋水仙碱位点并且抑制秋水碱结合，是一种微管蛋白聚合的抑制剂，IC50值为 2.8 μM。

Tubulin polymerization-IN-36

还可以

产品编号 T60758Cas号 2011784-91-9

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

大包装 & 定制

加入购物车

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

联系我们获取更多批次信息

资源下载

产品操作手册

产品介绍

生物活性

产品描述

Tubulin polymerization-IN-36 is able to be used in cancer research, for example, lymphomas. Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding, that is an inhibitor of tubulin polymerization with IC50 of 2.8 μΜ[1].

体外活性

Tubulin polymerization-IN-36 (compound 2e, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50% [1]. Tubulin polymerization-IN-36 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells [1]. Tubulin polymerization-IN-36 (5 μΜ) inhibits colchicine binding to tubulin by 88% [1]. Tubulin polymerization-IN-36 shows cytotoxicity against MCF-7 cells (IC 50 : 0.29 μΜ) [1]. Cell Proliferation Assay [1] Cell Line: VL51, MINO, HBL1, SU-DHL-10 cells. Concentration: 0-10 μΜ Incubation Time: 72 h Result: Inhibited cell proliferation to 38%, 0.8%, 7.1%, 30.5% at 1 μΜ, respectively. IC 50 s: 0.04, 0.02, 0.02, 0.03 μΜ, respectively. Cell Cycle Analysis [1] Cell Line: VL51 and MINO cells Concentration: 50 and 500 nM Incubation Time: 24, 48 and 72 h Result: Arrested cell in G2/M phase.