|
TMPY-04153
|
RNF43 Protein, Human, Recombinant (His)
ring finger protein 43,URCC,RNF43,RNF124
|
Human
|
HEK293 Cells
|
|
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.5 kDa and t... |
|
TMPY-00150
|
IGF2/IGF-II Protein, Human, Recombinant
PP9974,胰岛素样生长因子,C11orf43,IGF-II,insulin-like growth factor 2
|
Human
|
P. pastoris (Yeast)
|
|
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br... |
|
TMPY-02292
|
IGSF11 Protein, Human, Recombinant (His)
CT119,immunoglobulin superfamily, member 11,BT-IgSF,Igsf13,C...
|
Human
|
HEK293 Cells
|
|
Immunoglobulin superfamily member 11(IGSF11) is expressed on the plasma membrane in the testis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome reaction. IGSF proteins share significant homology with endothelial cell-selective adhesion molecule and coxsackievirus and adenovirus receptor, which mediates cell attachment and homotypic intercellular interactions. In clinical, the IGSF11 has been reported to overexpressed in colorectal cancers and hep... |
|
TMPY-00365
|
GALNT7 Protein, Human, Recombinant (His)
GalNAcT7,polypeptide N-acetylgalactosaminyltransferase 7,GAL...
|
Human
|
HEK293 Cells
|
|
GalNAc-transferase-7 (GALNT7) is essential for the regulation of cell proliferation and has been implicated in tumorigenesis. Colorectal cancer (CRC) arises in a multistep molecular network process, which is from either discrete genetic perturbation or epigenetic dysregulation. GALNT7 acts as a glycosyltransferase in protein O-glycosylation, involving in the occurrence and development of CRC. GALNT7 silencing significantly attenuated the proliferation, clonogenicity and migration of LSCC cells a... |
|
TMPY-02575
|
PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)
CIMT1,PPARγ,GLM1,PPARgamma,PPARG1,PPARG2,NR1C3,peroxisome pr...
|
Human
|
Baculovirus Insect Cells
|
|
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proli... |
|
TMPY-01442
|
DMBT1 Protein, Human, Recombinant (His)
GP340,deleted in malignant brain tumors 1,muclin
|
Human
|
HEK293 Cells
|
|
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo... |
|
TMPH-02218
|
JUN Protein, Human, Recombinant (His)
p39,JUN,Transcription factor Jun,Transcription factor AP-1 s...
|
Human
|
Baculovirus Insect Cells
|
|
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells. JUN Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with C-6x... |
|
TMPY-04149
|
RNF43 Protein, Human, Recombinant (hFc)
RNF43,RNF124,URCC,ring finger protein 43
|
Human
|
HEK293 Cells
|
|
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. The outer mitochondrial membrane 34 (TOMM34) and ring finger protein 43 (RNF43) as highly expressed oncogenes in malignant colorectal tumors. RNF43 is a tumour suppressor gene that suppresses the Wnt-beta-catenin signalling pathway. RNF43 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.8 kDa and t... |
|
TMPH-02219
|
JUN Protein, Human, Recombinant (His & Myc)
Proto-oncogene c-Jun,p39,V-jun avian sarcoma virus 17 oncoge...
|
Human
|
E. coli
|
|
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. Binds to the USP28 promoter in colorectal cancer (CRC) cells. JUN Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system wi... |
|
TMPK-01131
|
Neogenin Protein, Human, Recombinant (hFc)
NEO,NGN,IGDCC2,NEO1,neogenin 1
|
Human
|
HEK293 Cells
|
|
Neogenin is a multifunctional transmembrane receptor belonging to the immunoglobulin superfamily. It displays identical secondary structure to deleted in colorectal cancer (DCC), a netrin receptor that is involved in axon guidance and cell survival. |
|
TMPY-02572
|
TXNDC17 Protein, Human, Recombinant
thioredoxin domain containing 17,TXNL5,TRP14
|
Human
|
E. coli
|
|
Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein family that lacks activity with classical Trx1 substrates. TXNDC17 is a novel 14-kDa disulfide reductase of the TXN (thioredoxin) family. TXNDC17 is involved in the TNF (tumor necrosis factor) signaling pathway. Moreover, TXNDC17 plays an important role in Taxol resistance via enha... |
|
TMPY-00497
|
ZG16 Protein, Human, Recombinant (mFc)
JCLN1,zymogen granule protein 16,ZG16A,JCLN
|
Human
|
HEK293 Cells
|
|
Zymogen granule protein 16 (ZG16) is one of the most significantly down-regulated genes in colorectal cancer (CRC) tissues. Proteomic analyses of mucus have identified the lectin-like protein ZG16 as an abundant mucus component, which is significantly decreased in CRC samples compared to adjacent non-tumor tissues and associated with prognosis of patients. |
|
TMPY-05168
|
Syndecan-2 Protein, Mouse, Recombinant (His)
AA960457,4833414L08Rik,Hspg1,Synd2,syndecan 2,syndecan-2
|
Mouse
|
HEK293 Cells
|
|
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Syndecan-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is P43407. |
|
TMPK-00898
|
EphB3 Protein, Human, Recombinant (His)
EC 2.7.10.1,EPHB3,ETK2,EK2,HEK2,AW456895,Sek4,MDK5,Cek10,TYR...
|
Human
|
HEK293 Cells
|
|
Although EphB3 expression is down-regulated in colorectal cancer (CRC) cells compared with normal intestinal epithelial cells.EphB3 is down-regulated in CRC compared to normal mucosa. Hypermethylation of CpG island is contributed to downregulation of EphB3 in CRC. EphB3 expression in tumor cells may be a useful prognostic indicator for patients with CRC. |
|
TMPY-04249
|
Syndecan-2 Protein, Human, Recombinant (His)
syndecan 2,HSPG1,CD362,SYND2,HSPG
|
Human
|
HEK293 Cells
|
|
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Syndecan-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.4 kDa and the accession number is A0A024R9D1. |
|
TMPJ-00796
|
Serpin E2 Protein, Human, Recombinant (His)
PN-1,PI-7,Protease nexin 1,PI7,GDN,Peptidase inhibitor 7,Ser...
|
Human
|
HEK293 Cells
|
|
Serpin E2 is a secreted protein that belongs to the serpin family. Serpin E2 is a serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Serpin E2 expression is weak or absent in all normal pancreas and chronic pancreatitis tissue. In contrast, it was strongly over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples. Serpin E2 promotes neurite extension by inhibiting thrombin. It also can bind heparin. It has been shown tha... |
|
TMPK-01323
|
CEACAM1 Protein, Canine, Recombinant (His)
CEACAM1,BGP1,BGP,CD66a,BGPI
|
Canine
|
HEK293 Cells
|
|
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is the major antigen of the CD66 cluster of granulocyte differentiation antigens. The present study aimed to assess the biological function of CEACAM-1 on the growth of human colorectal cancer (CRC) cells in vitro. CEACAM1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 43.62 kDa and the accession number is XP_038509497.1. |
|
TMPK-00869
|
CEACAM1 Protein, Mouse, Recombinant (aa 35-428, His)
BGP,CEACAM1,BGP1,CD66a,BGPI
|
Mouse
|
HEK293 Cells
|
|
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM-1) is the major antigen of the CD66 cluster of granulocyte differentiation antigens. The present study aimed to assess the biological function of CEACAM-1 on the growth of human colorectal cancer (CRC) cells in vitro. CEACAM1 Protein, Mouse, Recombinant (aa 35-428, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 44.7 kDa and the accession number is P31809-1. |
|
TMPY-03859
|
DHRS9 Protein, Human, Recombinant (His)
3α-HSD,RDHTBE,3ALPHA-HSD,RDH-E2,RETSDR8,dehydrogenase/reduct...
|
Human
|
E. coli
|
|
Dehydrogenase/reductase (SDR family) member 9 (DHRS9) is aberrantly expressed in colorectal cancer (CRC), the decreased expression of DHRS9 correlates with tumor progression and may serve as a potential prognostic biomarker in CRC. The human regulatory macrophage (Mreg) has emerged as a promising cell type for use as a cell-based adjunct immunosuppressive therapy in solid organ transplant recipients. DHRS9 is a specific and stable marker of human Mregs. |
|
TMPY-03673
|
REG3B Protein, Mouse, Recombinant (His)
Pap,HIP,REG-III,PAP1
|
Mouse
|
HEK293 Cells
|
|
Expression of REG3B was sufficient to inhibit cytokine-induced activation of STAT3 in IECs. The human REG3beta protein, the functional counterpart of mouse REG3B, inhibited STAT3 activity in human 293T cells, and its expression level in colorectal tumors correlated inversely with pSTAT3 level and survival times of patients. REG3B negatively regulates cytokine-induced activation of STAT3 in colon epithelial cells. This pathway might be targeted in patients with colitis to reduce carcinogenesis. |
|
TMPK-01306
|
CDH3 Protein, Cynomolgus, Recombinant (His)
PCAD,CDHP,CAD3,Placental cadherin,HJMD,Cadherin-3,CDH3,P-cad...
|
Cynomolgus
|
HEK293 Cells
|
|
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag.... |
|
TMPK-00800
|
CDH3 Protein, Mouse, Recombinant (His)
HJMD,CDHP,CAD3,P-cadherin,Placental cadherin,PCAD,CDH3,Cadhe...
|
Mouse
|
HEK293 Cells
|
|
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The ... |
|
TMPY-03989
|
PFDN1 Protein, Human, Recombinant (His)
PDF,PFD1,prefoldin subunit 1
|
Human
|
E. coli
|
|
PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1 was involved in the progression of CRC, and provide new insights into PFDN1 as a potential therapeutic target for colorectal cancer (CRC) treatment. PFDN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is ... |
|
TMPK-01332
|
LY6G6D Protein, Cynomolgus, Recombinant (His)
Ly6-D,C6orf23,G6D,MEGT1,NG25,Protein Ly6-D
|
Cynomolgus
|
HEK293 Cells
|
|
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. LY6G6D Protein, Cynomolgus, Recombinant (His) is expresse... |
|
TMPK-00851
|
CDH3 Protein, Human, Recombinant (aa 108-654, His)
CAD3,Placental cadherin,PCAD,HJMD,CDH3,P-cadherin,Cadherin-3...
|
Human
|
HEK293 Cells
|
|
Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer. Inhibited CDH3 expression could upregulate E-cadherin, downregulated N-cadherin, which may control invasion and migration. CDH3 Protein, Human, Recombinant (aa 108-654, His) is expressed in HEK293 mammalian cells with C-H... |
|
TMPH-01699
|
SMAD2 Protein, Human, Recombinant (His & SUMO)
JV18-1,SMAD2,SMAD family member 2,Mothers against decapentap...
|
Human
|
E. coli
|
|
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3... |
|
TMPY-02046
|
PFDN1 Protein, Mouse, Recombinant (His)
AU044714,AA408327,2700086I23Rik,prefoldin subunit 1
|
Mouse
|
E. coli
|
|
PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1 was involved in the progression of CRC, and provide new insights into PFDN1 as a potential therapeutic target for colorectal cancer (CRC) treatment. PFDN1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is ... |
|
TMPJ-01155
|
PDCD4 Protein, Human, Recombinant (His)
Programmed Cell Death Protein 4,Protein 197/15a,Neoplastic T...
|
Human
|
E. coli
|
|
Programmed Cell Death Protein 4 (PDCD4) is a member of the PDCD4 family. PDCD4 and EIF4A1 form a heterotrimer. One molecule of PDCD4 binds two molecules of EIF4A1. PDCD4 takes part in apoptosis via inhibiting translation initiation and cap-dependent translation.PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. Overexpression of PDCD4 in carc... |
|
TMPK-00752
|
LY6G6D Protein, Human, Recombinant (hFc)
G6D,MEGT1,C6orf23,NG25,Protein Ly6-D,Ly6-D
|
Human
|
HEK293 Cells
|
|
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. LY6G6D Protein, Human, Recombinant (hFc) is expressed in ... |
|
TMPK-00753
|
LY6G6D Protein, Human, Recombinant (His)
C6orf23,Ly6-D,NG25,G6D,Protein Ly6-D,MEGT1
|
Human
|
HEK293 Cells
|
|
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. LY6G6D Protein, Human, Recombinant (His) is expressed in ... |
|
TMPH-01048
|
CEACAM5 Protein, Human, Recombinant (E398K, His)
Carcinoembryonic antigen-related cell adhesion molecule 5,CD...
|
Human
|
HEK293 Cells
|
|
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. CEACAM5... |
|
TMPK-00754
|
LY6G6D Protein, Human, Recombinant (His & Strep-II)
C6orf23,MEGT1,Protein Ly6-D,NG25,G6D,Ly6-D
|
Human
|
HEK293 Cells
|
|
LY6G6D is a selectively expressed colorectal cancer antigen that can be used for targeting a therapeutic T-cell response by a T-cell engager.LY6G6D was identified as a selectively expressed CRC antigen that can be utilized to potently re-direct and activate cytotoxic T-cells to lyse LY6G6D expressing CRC using a TcE. This effect can be spread to target negative neighboring tumor cells, potentially leading to improved therapeutic efficacy. LY6G6D Protein, Human, Recombinant (His & Strep-II) is ex... |
|
TMPY-03329
|
DPEP1 Protein, Human, Recombinant (His)
MBD1,dipeptidase 1,MDP,RDP
|
Human
|
HEK293 Cells
|
|
Dehydropeptidase-I, also known as DPEP1, is a kidney membrane enzyme. Its expression in normal colonic mucosa is very low, but it is highly expressed in colorectal adenoma and cancer specimens and is negatively correlated with parameters of pathological aggressiveness and poor prognosis. The overexpression of DPEP1 suppressed tumor cells invasiveness and increased sensitivity to chemotherapeutic agent Gemcitabine. Growth factor EGF treatment decreased DPEP1 expression. Dehydropeptidase-I m... |
|
TMPY-02249
|
FABP6 Protein, Human, Recombinant
I-BABP,I-BAP,ILLBP,I-15P,ILBP3,I-BALB,ILBP,fatty acid bindin...
|
Human
|
E. coli
|
|
Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family. Isoform2 of FABP6 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform1of FABP6 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isof... |
|
TMPJ-00529
|
FABP6 Protein, Human, Recombinant (His)
Ileal Lipid-Binding Protein,I-BABP,Intestinal Bile Acid-Bind...
|
Human
|
E. coli
|
|
Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine to the ileum where it is involved in the enterohepatic circulation of bile acids. FABP6 forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level)... |
|
TMPY-04765
|
PKLR Protein, Human, Recombinant (His)
PKRL,PKR,RPK,PKL,PK1,pyruvate kinase, liver and RBC
|
Human
|
E. coli
|
|
Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pathway and the most common cause of hereditary nonspherocytic hemolytic anemia. Over 250 PKLR-gene mutations have been described, including missense/nonsense, splicing and regulatory mutations, small insertions, small and gross deletions, causing PKD and hemolytic anemia of variabl... |
|
TMPY-03419
|
SMAD3 Protein, Human, Mouse, Rat, Recombinant (His & GST)
SMAD family member 3
|
Human,Mouse,Rat
|
Baculovirus Insect Cells
|
|
SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice,... |
|
TMPY-01249
|
Cathepsin V Protein, Human, Recombinant (His)
CTSV,cathepsin V,MGC125957,CATL2,CTSU,CTSL2
|
Human
|
HEK293 Cells
|
|
Cathepsin V (CTSV), also known as Cathepsin L2, CTSL2, and CATL2, is a member of the peptidase C1 family. It is predominantly expressed in the thymus and testis. Cathepsin V is also expressed in corneal epithelium, and to a lesser extent in conjuctival epithelium and skin. It is a lysosomal cysteine proteinase that may play an important role in corneal physiology. It has about 75% protein sequence identity to murine cathepsin L. The fold of this enzyme is similar to the fold adopted by other mem... |
|
TMPJ-01083
|
Serpin E2 Protein, Mouse, Recombinant (His)
Pi7,Protease nexin I,Spi4,Pn1,Serine protease-inhibitor 4,PI...
|
Mouse
|
HEK293 Cells
|
|
Serpin E2 is a member of the Serpin superfamily. It is differentially expressed during neuronal differentiation and is able to transform human embryonic kidney cells into neuronlike cells. Its over-expression in mice leads to progressive neuronal and motor dysfunction in these animals. It is also over-expressed in the majority of pancreatic carcinoma as well as gastric and colorectal cancer samples whereas it is weakly expressed in all normal pancreas and chronic pancreatitis tissue samples. Ser... |
|
TMPY-04267
|
MSH2 Protein, Human, Recombinant (His & GST)
FCC1,COCA1,HNPCC1,HNPCC,LCFS2,mutS homolog 2
|
Human
|
Baculovirus Insect Cells
|
|
MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and binds to various DNA damage-induced adducts to trigger cell cycle arrest or apoptosis. Loss or depletion of MSH2 from cells renders resistance to certain DNA-damaging agents. Therefore, the level of MSH2 determines the DNA damage response.MSH2 is a central component of the mismatch r... |
|
TMPY-02100
|
TEM7 Protein, Human, Recombinant (His)
TEM3,plexin domain containing 1,TEM7
|
Human
|
HEK293 Cells
|
|
Plexin domain-containing protein 1, also known as tumor endothelial marker 3, tumor endothelial marker 7 and PLXDC1 and TEM3, is a secreted, cytoplasm and single-pass type I membrane protein that belongs to the plexin family. PLXDC1 / TEM3 is detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. It is expressed in fibrovascular membrane with increased expression in individuals with proliferative diabeti... |
|
TMPY-01268
|
SMYD3 Protein, Human, Recombinant (GST)
SET and MYND domain containing 3,ZMYND1,KMT3E,ZNFN3A1,bA74P1...
|
Human
|
Baculovirus Insect Cells
|
|
SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains one MYND-type zinc finger and one SET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). SMYD3 plays an important role in transcriptional reg... |
|
TMPY-00924
|
SMAC Protein, Human, Recombinant (His)
DFNA64,diablo, IAP-binding mitochondrial protein,SMAC
|
Human
|
E. coli
|
|
Apoptosis is an essential processes required for normal development and homeostasis of all metazoan organisms. Second Mitochondria-Derived Activator of Caspases (Smac) or Direct IAP Binding Protein with low isoelectric point, pI (Diablo) is a proapoptogenic mitochondrial protein that is released to the cytosol in response to diverse apoptotic stimuli, including commonly used chemotherapeutic drugs. The current knowlege about structure and function of Smac/Diablo during programmed cell death, bot... |
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