|
TMPH-01751
|
Nephrin/NPHS1 Protein, Human, Recombinant (His)
Nephrin,Renal glomerulus-specific cell adhesion rec...
|
Human
|
E. coli
|
|
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. Nephrin/NPHS1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.1 kDa and the accession number is O60500. |
|
TMPH-02094
|
STK11 Protein, Human, Recombinant (His & SUMO)
Liver kinase B1,Renal carcinoma antigen NY-REN-19,S...
|
Human
|
E. coli
|
|
STK11 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 64.3 kDa and the accession number is Q15831. |
|
TMPJ-00797
|
LDHB Protein, Human, Recombinant (His)
LDH-B,Renal Carcinoma Antigen NY-REN-46,LDH-H,LDH H...
|
Human
|
E. coli
|
|
L-Lactate Dehydrogenase B Chain (LDH-B) is a member of the lactate dehydrogenase family that consists of three members, LDH-A, LDH-B and LDH-C; members of this family function as powerful markers for germ cell tumors. LDH-B is an oxidoreductase that catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+. It converts pyruvate to lactate when oxygen is absent or in short supply and it performs the reverse reaction during the Cori cycle in the liver.... |
|
TMPH-03132
|
AVPR2 Protein, Pig, Recombinant (His & SUMO)
AVPR2,Vasopressin V2 receptor,V2R,AVPR V2,Antidiuretic hormo...
|
Sus scrofa (Pig)
|
E. coli
|
|
Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption. AVPR2 Protein, Pig, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 24.7 kDa and the accession number is P32307. |
|
TMPH-01745
|
NOX4 Protein, Human, Recombinant (Cell-Free, His)
NOX4,Kidney oxidase-1,Renal NAD(P)H-oxidase,Kidney ...
|
Human
|
E. coli
|
|
NOX4 Protein, Human, Recombinant (Cell-Free, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 69.8?kDa and the accession number is Q9NPH5. |
|
TMPH-01746
|
NOX4 Protein, Human, Recombinant (E. coli, His)
Kidney superoxide-producing NADPH oxidase,NOX4,NADPH oxidase...
|
Human
|
E. coli
|
|
NOX4 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.8 kDa and the accession number is Q9NPH5. |
|
TMPJ-00724
|
LDHA Protein, Human, Recombinant (His)
LDH-M,Renal Carcinoma Antigen NY-REN-59,Cell Prolif...
|
Human
|
E. coli
|
|
L-Lactate Dehydrogenase A Chain (LDHA) is an enzyme that catalyzes the conversion of L-lactate and NAD+ to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA contains an N-terminal coenzyme binding region, a central catalytic site, and at least nine utilized Lys acetylation and two Tyr phosphorylation sites. LDHA belongs to the lactate dehydrogenase family, expressed predominantly in muscle tissue. LDHA mutations have been linked to exertional myoglobinuria. |
|
TMPH-01429
|
HSP90AA1 Protein, Human, Recombinant (His)
Lipopolysaccharide-associated protein 2,Heat shock 86 kDa,
|
Human
|
E. coli
|
|
HSP90AA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.0 kDa and the accession number is P07900. |
|
TMPH-02523
|
AQP2 Protein, Mouse, Recombinant (His)
ADH water channel,cph,Water channel protein for renal
|
Mouse
|
E. coli
|
|
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. AQP2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.5 kDa and the accession number is P56402. |
|
TMPH-03246
|
AQP2 Protein, Rat, Recombinant (His)
cph,AQP-2,Collecting duct water channel protein,ADH water ch...
|
Rat
|
E. coli
|
|
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis. AQP2 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 30.4 kDa and the accession number is P34080. |
|
TMPJ-00755
|
CRYAB Protein, Human, Recombinant (His)
α(B)-Crystallin,Alpha(B)-Crystallin,Heat Shock Protein Beta-...
|
Human
|
E. coli
|
|
α Crystallin B Chain (CRYAB) is a cytoplasmic protein that belongs to the small heat shock protein (HSP20) family. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. Alpha crystallins acts as molecular chaperones and hold them in in large soluble aggregates. CRYAB is expressed widely in many tissues and or... |
|
TMPJ-01010
|
PLA2G16 Protein, Human, Recombinant (His)
Renal Carcinoma Antigen NY-REN-65,HRAS-Like Suppres...
|
Human
|
E. coli
|
|
Group XVI Phospholipase A1/A2 (PLA2G16) belongs to the H-rev 107 family. PLA2G16 is expressed in a number of human tumors including ovarian carcinomas, lung carcinomas. PLA2G16 is involved in the regulation of differentiation and survival. PLA2G16 regulates adipocyte lipolysis and release of fatty acids through a G-protein coupled pathway involving prostaglandin and EP3. It has also been reported to play a crucial role in the development of obesity in mouse models. |
|
TMPH-02880
|
Renalase Protein, Mouse, Recombinant (His & SUMO)
Monoamine oxidase-C,Renalase,Rnls
|
Mouse
|
E. coli
|
|
Renalase Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 52.0 kDa and the accession number is A7RDN6. |
|
TMPY-02956
|
Apolipoprotein L/APOL1 Protein, Human, Recombinant (His)
APOL1,apolipoprotein L1,APOL,FSGS4,APOL-I,APO-L
|
Human
|
Baculovirus Insect Cells
|
|
APOL1, also known as apolipoprotein L1, is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. APOL1 belongs to the apolipoprotein L family. It may play a role in lipid exchange and transport throughout the body. It may also participate in reverse cholesterol transport from peripheral cells to the liver. Defects in APOL1 are the cause of focal segmental glomer... |
|
TMPJ-00071
|
EPO/Erythropoietin Protein, Human, Recombinant (His)
Erythropoietin,EPO,红细胞生长素,Epoetin
|
Human
|
HEK293 Cells
|
|
Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EP... |
|
TMPY-04483
|
IRAK4 Protein, Human, Recombinant (His)
IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...
|
Human
|
Baculovirus Insect Cells
|
|
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ... |
|
TMPJ-00504
|
Serpin A8 Protein, Human, Recombinant (His)
AGT and SERPINA8,Angiotensinogen,Serpin A8
|
Human
|
HEK293 Cells
|
|
Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the encoding gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. |
|
TMPK-01128
|
LRG1 Protein, Mouse, Recombinant (His)
Leucine-rich α-2-glycoprotein,Leucine-rich alpha-2-glycoprot...
|
Mouse
|
HEK293 Cells
|
|
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular complications of diabetes mellitus that is characterized by proteinuria and glomerular structural changes. LRG1 is a novel pro-angiogenic factors involved in the abnormal angiogenesis and renal fibrosis in DN. LRG1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammali... |
|
TMPK-00526
|
LRG1 Protein, Cynomolgus, Recombinant (His)
Leucine-rich α-2-glycoprotein,LRG1,LRG,Leucine-rich alpha-2-...
|
Cynomolgus
|
HEK293 Cells
|
|
Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular complications of diabetes mellitus that is characterized by proteinuria and glomerular structural changes. LRG1 is a novel pro-angiogenic factors involved in the abnormal angiogenesis and renal fibrosis in DN. LRG1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 ma... |
|
TMPJ-00931
|
Serpin A4 Protein, Human, Recombinant (His)
Kallistatin,Peptidase Inhibitor 4,KST,Kallikrein Inhibitor,S...
|
Human
|
HEK293 Cells
|
|
Serpin Peptidase Inhibitor, Clade A (α-1 Antiproteinase, Antitrypsin), Member 4 (Serpin A4) is a member of the Serpin family. Serpin A4 exists as a monomer and some homodimers. Serpin A4 is expressed by the liver and secreted in plasma. Serpin A4 is a regulator of vascular homeostasis capable of controlling a wide spectrum of biological actions in the cardiovascular and renal systems. It can inhibit intracellular reactive oxygen species formation in cultured cardiac and renal cells. In addition,... |
|
TMPH-03293
|
FGF-23 Protein, Rat, Recombinant (E. coli, His)
Fgf23,Fibroblast growth factor 23
|
Rat
|
E. coli
|
|
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL. |
|
TMPY-03460
|
DCXR Protein, Human, Recombinant (His)
XR,P34H,HCR2,HCRII,PNTSU,SDR20C1,DCR,dicarbonyl/L-xylulose r...
|
Human
|
E. coli
|
|
DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and distal sections of the corpus region. HCR2 is weakly or not expressed in brain, lung, heart, spleen and testis. DCXR catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. DCXR participates in the uronate cycle of... |
|
TMPH-02434
|
PTH Protein, Cynomolgus, Recombinant (His & Myc)
Parathyroid hormone,PTH,Parathyrin
|
Cynomolgus
|
E. coli
|
|
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. PTH Protein, Cynomolgus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 16.9 kDa and the accession number is Q9XT35. |
|
TMPH-03348
|
PTH Protein, Rat, Recombinant (His & Myc)
Parathyrin,PTH,Parathyroid hormone
|
Rat
|
E. coli
|
|
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells. PTH Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 16.9 kDa and the accession number is Q9XT35. |
|
TMPH-02595
|
Collectrin Protein, Mouse, Recombinant (His & Myc & SUMO)
Cltrn,Collectrin,Tmem27,Nx17,Transmembrane protein 27
|
Mouse
|
E. coli
|
|
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication. |
|
TMPH-03294
|
FGF-23 Protein, Rat, Recombinant (His)
Fibroblast growth factor 23,Fgf23
|
Rat
|
P. pastoris (Yeast)
|
|
Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Regulator of vitamin-D metabolism. Negatively regulates osteoblasts differentiation and matrix mineralization. Acts directly on the parathyroid to decrease PTH secretion. Upregulates EGR1 expression in the presence of KL. FGF-23 Protein, Rat, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 27.5 kDa and the accession number is Q8VI82. |
|
TMPK-00751
|
FSTL3 Protein, Human, Recombinant (His)
FSTL3,FLRGFSRP,Follistatin-like 3,FLRG
|
Human
|
HEK293 Cells
|
|
Follistatin-like 3 (FSTL3) is a novel cytokine that regulates insulin sensitivity and counteracts activin/myostatin signalling. In the present study, regulation of FSTL3 in renal dysfunction was investigated in both human chronic kidney disease (CKD) and acute kidney dysfunction (AKD). Furthermore, mFSTL3 expression was analysed in insulin-sensitive tissues in a mouse model of CKD. |
|
TMPK-00172
|
B7-H4 Protein, Human, Recombinant (His & Avi)
B7H4,B7x,VTCN1,PRO1291,B7S1,B7h.5,FLJ22418,B7-H4
|
Human
|
HEK293 Cells
|
|
B7-H4, also known as B7x and B7S1, is a 50-80 kDa glycosylated member of the B7 family of immunomodulatory proteins.B7-H4 is up-regulated in several carcinomas in correlation with tumor progression and metastasis. A soluble form of B7-H4 is elevated in the serum of ovarian cancer, renal cell carcinoma, and rheumatoid arthritis patients, also in correlation with advanced disease status . |
|
TMPK-00574
|
MRC2 Protein, Canine, Recombinant (His)
Mannose receptor C type 2
|
Canine
|
HEK293 Cells
|
|
MRC2 (Mannose Receptor C Type 2) is a constitutively recycling endocytic receptor belonging to the mannose receptor family, which has been found to be closely involved with cancer metastasis. MRC2 expresses an extracellular fibronectin type II domain that binds to and internalizes collagen, suggesting that it may play a role in modulating renal fibrosis. MRC2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 57.76 kDa and ... |
|
TMPK-00151
|
Complement Factor D/CFD Protein, Mouse, Recombinant (hFc)
C3 convertase activator,AMBP-1,PFD,FACTOR D,CFD,ADN,EC 3.4.2...
|
Mouse
|
HEK293 Cells
|
|
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Mouse, Recom... |
|
TMPJ-00876
|
FAH Protein, Human, Recombinant (His)
Fumarylacetoacetate Hydrolase,β-Diketonase,FAH,FAA,Fumarylac...
|
Human
|
HEK293 Cells
|
|
Fumarylacetoacetase belongs to the FAH family. Fumarylacetoacetase is primary expressed in liver and kidney. It exists as a homodimer and catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. Defects in Fumarylacetoacetase cause tyrosinemia type 1, which is congenital metabolism defect characterized by elevated levels of tyrosine in the blood and urine, and hepatorenal manifestations. Typical features include renal tubular injury, self-mutilation, hepatic necrosis, ep... |
|
TMPJ-00265
|
Serpin F1 Protein, Mouse, Recombinant
Pedf,Caspin,Stromal cell-derived factor 3,Sdf3,Pigment epith...
|
Mouse
|
E. coli
|
|
Serpin F1 is secreted Neurotrophic protein and belongs to the serpin family. Serpin F1 Highly expressed in the liver, gastric glandular mucosa and renal tubules. It is also expressed in the brain, heart, lung retina and testes. It induces extensive neuronal differentiation in retinoblastoma cells. It is potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, exhibits no serine protease inhibitory activi... |
|
TMPK-01225
|
MRC2 Protein, Human, Recombinant (His)
C-type lectin domain family 13 member E, Endocytic receptor ...
|
Human
|
HEK293 Cells
|
|
MRC2 (Mannose Receptor C Type 2) is a constitutively recycling endocytic receptor belonging to the mannose receptor family, which has been found to be closely involved with cancer metastasis. MRC2 expresses an extracellular fibronectin type II domain that binds to and internalizes collagen, suggesting that it may play a role in modulating renal fibrosis. MRC2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 57.64 kDa and t... |
|
TMPJ-01350
|
XPNPEP3 Protein, Human, Recombinant (His)
XPNPEP3,X-Pro Aminopeptidase 3,Aminopeptidase P3,APP3,Probab...
|
Human
|
E. coli
|
|
Probable Xaa-Pro Aminopeptidase 3 (XPNPEP3) is a member of the peptidase M24B family. XPNPEP3 has two isoforms and both are widely expressed. XPNPEP3 is localized in the Mitochondrion. XPNPEP3 catalyzes the release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 which is a disorder with features of nephronophthisis, a cystic kidney disease leading to end-s... |
|
TMPK-00755
|
Complement Factor D/CFD Protein, Human, Recombinant (hFc)
C3 convertase activator,DF,AMBP-1,EC 3.4.21,EC 3.4.21.46,Adi...
|
Human
|
HEK293 Cells
|
|
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Human, Recom... |
|
TMPJ-00457
|
OGG1 Protein, Human, Recombinant
OGH1,N-Glycosylase/DNA Lyase,DNA-(Apurinic or Apyrimidinic S...
|
Human
|
E. coli
|
|
Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma. |
|
TMPK-00138
|
CXCL16 Protein, Mouse, Recombinant (hFc)
SR-PSOX,SCYB16,SRPSOX,CXCLG16,CXCL16
|
Mouse
|
HEK293 Cells
|
|
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. CXCL16 Pro... |
|
TMPH-02432
|
Legumain Protein, Cynomolgus, Recombinant (E. coli, His & Myc)
Legumain,Protease, cysteine 1,LGMN,Asparaginyl endopeptidase
|
Cynomolgus
|
E. coli
|
|
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Legumain Protein, Cynomolg... |
|
TMPK-00469
|
CXCL16 Protein, Human, Recombinant (hFc)
SR-PSOX,SCYB16,CXCL16,CXCLG16,SRPSOX
|
Human
|
HEK293 Cells
|
|
CXC chemokine ligand 16 (CXCL16) is a CXC soluble chemokine, an adhesion molecule and a cell surface scavenger receptor. CXCL16 regulates inflammation, tissue injury and fibrosis. Parenchymal renal cells, vascular wall cells, leukocytes and platelets express and/or release CXCL16 under the regulation of inflammatory mediators. CXCL16 expression is increased in experimental and human nephropathies. Targeting CXCL16 protected from experimental glomerular injury or interstitial fibrosis. CXCL16 Pro... |
|
TMPK-00671
|
Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His)
Adipsin,CFD,ADN,Complement factor D,DF,AMBP-1,EC 3.4.21,FACT...
|
Rhesus
|
HEK293 Cells
|
|
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Rhesus macaq... |
|
TMPJ-01306
|
CFHR5 Protein, Human, Recombinant (His)
Complement factor H-related protein 5,CFHR5,FHR5,CFHL5
|
Human
|
HEK293 Cells
|
|
Complement factor H-related protein 5(FHR-5 for short), is a secreted protein which contains 9 Sushi (CCP/SCR) domains. It is expressed by the liver and secreted in plasma. The pattern of the deposits is similar to other complement components, suggesting that FHR-5 may play a role in complement activation and regulation. Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may contribute to the disease. In contrast to typical hemolytic uremic syndrome, atypica... |
|
TMPH-02431
|
Legumain Protein, Cynomolgus, Recombinant (His & Myc)
Legumain,Protease, cysteine 1,Asparaginyl endopeptidase,LGMN
|
Cynomolgus
|
Baculovirus Insect Cells
|
|
Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Legumain Protein, Cynomolg... |
|
TMPH-00331
|
ALS3 Protein, Candida albicans, Recombinant (B2M & His & Myc)
Adhesin 3,3D9 antigen,Agglutinin-like protein 3
|
Candida albicans
|
E. coli
|
|
Cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. ALS3 Prot... |
|
TMPY-01451
|
MESDC2 Protein, Human, Recombinant (His)
MESD,mesoderm development candidate 2,BOCA
|
Human
|
HEK293 Cells
|
|
MESD (Mesoderm Development LRP Chaperone) is a Protein Coding gene. LDLR chaperone MESD, also known as Mesoderm development protein, Mesoderm development candidate 2, Renal carcinoma antigen NY-REN-61, and MESDC2, is a member of the MESD family. It is widely expressed in the thyroid, placenta, and other tissues. MESDC2 is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). The LDLR maturation activity reside... |
|
TMPY-00261
|
Meprin beta Protein, Human, Recombinant (His)
meprin A, β,Meprin β,meprin A, beta
|
Human
|
HEK293 Cells
|
|
MEP1B (Meprin A Subunit Beta) is a Protein Coding gene. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in the kidney and intestine. Meprins are cell membrane, oligomeric metalloendopeptidases composed of two distinct but evolutionarily related subunits, alpha, and beta. MEP1A is mapped to the short arm of chromosome 6 by the use of radiation and som... |
|
TMPY-01579
|
GBA3 Protein, Human, Recombinant (His)
glucosidase, beta, acid 3 (gene/pseudogene),GBA3,MGC126878,K...
|
Human
|
Baculovirus Insect Cells
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Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to theglycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in r... |
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TMPY-02003
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FH/Fumarate Hydratase Protein, Human, Recombinant (His)
fumarate hydratase,MCL,LRCC,MCUL1,FMRD,HLRCC
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Human
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E. coli
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Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. Fumarate Hydratase is similar to some thermostable class II fumarases and func... |
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TMPJ-00817
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HO-1 Protein, Human, Recombinant
HO,HMOX1,HO-1,Heme Oxygenase 1,HO1
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Human
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E. coli
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Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy me... |
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TMPJ-00741
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PTH Protein, Human, Recombinant (His)
Parathyroid hormone,Parathyrin,PTH,Parathormone
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Human
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HEK293 Cells
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Parathyroid hormone (PTH) is a critical hormone in the regulation of Ca++ homeostasis. Parathyroid hormone is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid. This hormone is secreted from cells of the parathyroid glands and finds its major target cells in bone and kidney. Another hormone, parathyroid hormone-related protein, binds to the same receptor as parathyroid hormone and has major effects on development. Like most other protein hormon... |
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TMPJ-00082
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NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc)
Lipocalin-2,SV-40-induced 24P3 protein,Siderocalin LCN2,LCN2...
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Mouse
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HEK293 Cells
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Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell sig... |
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