Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and has a relatively long half-life.

在大鼠中,与基线值相比较,Torsemide增加血尿素氮和血浆肌酐浓度,且明显迅速地增加尿量.在二尖瓣关闭的犬中,Torsemide增加循环血管紧张素II和醛甾酮水平,而呋喃苯胺酸只增加血管紧张素II水平.

肾Henle厚上循环是Torsemide的主要作用位点,通过与K+,Na+,Cl-转运相互作用促进水,钠和氯化物的排泄。Torsemide剂量依赖地干扰盐皮质醛固酮的结合和分泌。Torsemide抑制醛固酮分泌,其由鼠,豚鼠和牛的肾上腺细胞分泌,并经血管紧张素,促肾上腺皮质激素,丁酰环AMP,皮质酮或在体外刺激。