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Cat. No. | Product Name | ||
---|---|---|---|
L2200 | 酪氨酸激酶分子库 | 1016 compounds | |
1016 种酪氨酸激酶抑制剂的独特集合,可用于高通量筛选和高内涵筛选; | |||
L9410 | 共价抑制剂库 | 1920 compounds | |
1920 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T41099 |
EGFR Protein Tyrosine Kinase Substrate
|
||
EGFR Protein Tyrosine Kinase Substrate is a EGFR protein tyrosine kinase substrate. | |||
TP1269 |
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9)
Tyrosine Protein Kinase JAK2 Phospho-Tyr8, 9 |
||
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from mouse JAK2, specifically composed of amino acids 475 to 491. | |||
T2314 |
PF-431396
|
FAK; PYK2 | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
PF 431396 是一种具有口服活性的 FAK (IC50:2 nM) 和 Pyk2 (IC50:11 nM)的抑制剂。 | |||
T5480 |
BI-4464
|
FAK; Ligands for Target Protein for PROTAC | Angiogenesis; Cytoskeletal Signaling; PROTAC; Tyrosine Kinase/Adaptors |
BI-4464 是一种高选择性的 ATP 竞争性 PTK2/FAK 抑制剂,IC50=17 nM。它可用于PROTAC 降解剂的 PTK2 配体。 | |||
T6997 |
SU6656
|
FAK; Akt; Src | Angiogenesis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
SU6656 是Src 家族激酶抑制剂,抑制 Src,Yes,Lyn,Fyn 的IC50分别为 280,20,130,170 nM。它还能抑制p-AKT。它可抑制FAK Y576/577、 Y925、Y861位点的磷酸化。 | |||
T9576 |
AMP-945
|
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
AMP-945 是一种粘着斑激酶抑制剂。 | |||
T9973 |
FAK-IN-7
|
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
FAK-IN-7 有潜在的抗增殖活性,是一种 FAK 抑制剂。 | |||
T6177 |
PF-562271 besylate
PF-00562271 Besylate |
FAK; PYK2; CDK | Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
PF-562271 besylate (PF-00562271 Besylate) 是一种可逆的,有效的,ATP 竞争性的 FAK(IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。 | |||
T2465 |
PF-562271
PF562271,PF 562271 |
FAK; PYK2; CDK | Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
PF-562271 是一种可逆的,有效的,ATP 竞争性的 FAK (IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。 | |||
T2001 |
PF-573228
PF 573228 |
Apoptosis; FAK | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
PF-573228是一种选择性的 FAK 抑制剂,对 FAK 纯化重组催化片段的 IC50值为4 nM。 | |||
T1835 |
Ibrutinib
伊布替尼,依鲁替尼,PCI-32765 |
Tyrosine Kinases; Src; BTK; Ligands for Target Protein for PROTAC | Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors |
Ibrutinib (PCI-32765) 是一种布鲁顿酪氨酸激酶 (BTK) 抑制剂 (IC50=0.5 nM),具有不可逆性和选择性。Ibrutinib 可以阻断 BTK 抑制 B 细胞的增殖和存活,具有抗肿瘤活性,可以用于治疗慢性淋巴细胞白血病等。 | |||
T2655 |
CEP-37440
CEP37440 |
FAK; ALK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
CEP-37440 是一种新型的 FAK (IC50:2.3 nM) 和 ALK (IC50:120 nM) 双重抑制剂。 | |||
T3041 |
ALK inhibitor 2
|
FAK; ALK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
ALK inhibitor 2 是嘧啶类 ALK 的有效抑制剂。它是一种睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2;IC50=37 nM) 和粘着斑激酶 (FAK;IC50=5 nM) 抑制剂。 | |||
T1918 |
NVP-TAE 226
TAE226 |
Apoptosis; FAK; c-Met/HGFR; PYK2; IGF-1R | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
NVP-TAE 226 (TAE226) 是一种具有 ATP 竞争性的双重FAK 和IGF-1R 抑制剂,IC50分别为 5.5 nM、140 nM。它还抑制Pyk2、胰岛素受体,IC50分为 3.5 nM、40 nM。 | |||
T21768 |
PF-562271 hydrochloride
PF-562271 HCl |
FAK; PYK2; CDK | Angiogenesis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
PF-562271 hydrochloride (PF-562271 HCl) 是一种可逆的,有效的,ATP 竞争性的 FAK (IC50:1.5 nM)和 Pyk2 (IC50:13 nM)激酶抑制剂。 | |||
T10285 |
ALK inhibitor 1
|
FAK; IGF-1R; ALK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
ALK inhibitor 1 是嘧啶类 ALK 的有效抑制剂。它是一种睾丸特异性丝氨酸/苏氨酸激酶 2 (TSSK2;IC50=31 nM) 和粘着斑激酶 (FAK;IC50=2 nM) 抑制剂。 | |||
T4337 |
PCI 29732
PCI29732,PCI-29732 |
Others; BCRP; BTK | Angiogenesis; Membrane transporter/Ion channel; Others; Tyrosine Kinase/Adaptors |
PCI 29732 是一种有效的可逆BTK 抑制剂,对 BTK、Lck 和 Lyn 的Kiapp 值分别为 8.2、4.6 和 2.5 nM。它通过竞争性结合ABCG2 的 ATP 结合位点来抑制ABCG2的功能。 | |||
T2281 |
GSK2256098
GSK 2256098,GSK-2256098,GTPL7939 |
Apoptosis; FAK | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
GSK2256098 (GTPL7939) 是一种选择性FAK 激酶抑制剂,抑制胰腺癌细胞的生长和存活。 | |||
T7541 |
PTP inhibitor 1
PTP Inhibitor II,alpha-溴-4-甲氧基苯乙酮 |
Phosphatase | Metabolism |
PTP inhibitor 1 是蛋白酪氨酸磷酸酶 (PTP) 抑制剂,具有抗血管生成作用。 | |||
T2066 |
Quizartinib
AC220,奎扎替尼 |
Apoptosis; FLT; Autophagy; Ligands for Target Protein for PROTAC | Angiogenesis; Apoptosis; Autophagy; PROTAC; Tyrosine Kinase/Adaptors |
Quizartinib (AC220) 是一种第二代 Ⅱ 型 FLT3 酪氨酸激酶抑制剂,具有口服活性和高选择性,抑制 FLT3-WT 和 FLT3-ITD 自磷酸化 (IC50=4.1/1.1 nM)。Quizartinib 可以诱导肿瘤细胞凋亡。 | |||
T1996 |
Defactinib
PF-04554878,VS-6063 |
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Defactinib (VS-6063) 是新型的 FAK 抑制剂,能够时间和剂量依赖性的抑制 FAK 在 Tyr397 位点磷酸化。 | |||
T0827 |
Cefsulodin sodium
Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠 |
Antibacterial; Antibiotic | Microbiology/Virology |
Cefsulodin sodium (Sulcephalosporin) 是β内酰胺抗生素,对缘脓杆菌和肠杆菌有活性。 | |||
T4636 |
Protein kinase inhibitors 1
|
Others; DYRK | Cell Cycle/Checkpoint; Others; Tyrosine Kinase/Adaptors |
Protein kinase inhibitors 1 是新型的 HIPK2 抑制剂,其 IC50=74 nM,Kd=9.5 nM。 | |||
T0263 |
Chloropyramine hydrochloride
Nilfan,盐酸氯吡胺,Alergosan,Halopyramine hydrochloride |
FAK; VEGFR; Histamine Receptor | Angiogenesis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Neuroscience; Tyrosine Kinase/Adaptors |
Chloropyramine hydrochloride (Alergosan) 是一种组胺受体 H1 拮抗剂,可抑制VEGFR-3和FAK 的生化功能。 | |||
T24730 |
Roslin 2 bromide
Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2 |
FAK; p53 | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) 是一种 p53 再激活剂,可破坏 FAK 和 p53 的结合。 Roslin 2 bromide 具有抗癌作用。 | |||
T2609 |
Masitinib
AB1010,马赛替尼 |
Apoptosis; FAK; c-Fms; FGFR; Bcr-Abl; PDGFR; Src; c-Kit; Hck | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Masitinib (AB1010) 是生物口服可利用的选择性 c-Kit 抑制剂 (对于人重组c-Kit,IC50=200 nM),它还抑制PDGFRα/β(IC50s=540/800 nM),Lyn(对 LynB 的IC50=510 nM),Lck,较小程度上抑制FGFR3和FAK。它有抗增殖,促凋亡活性,且毒性低。 | |||
T4185 |
lavendustin C
HDBA,NSC 666251,N-(2,5-二羟基苄基)-5-氨基水杨酸 |
CaMK; EGFR; Tyrosinase; Src | Angiogenesis; JAK/STAT signaling; Neuroscience; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
lavendustin C (NSC 666251) 是 Ca2+钙调蛋白依赖性激酶 II 抑制剂,IC50为 0.2 µM。它抑制 EGFR 相关酪氨酸激酶和 pp60c-src(+)激酶,IC50分别为 0.012 和 0.5 µM。 | |||
T1950 |
PND-1186
PND1186,PND 1186,VS-4718,SR-2516 |
Apoptosis; FAK | Angiogenesis; Apoptosis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
PND-1186 (VS-4718) 是一种高特异性的FAK 可逆抑制剂,IC50为 1.5 nM。它选择性促进肿瘤细胞凋亡。 | |||
T7119 |
Y15
1,2,4,5-苯四胺四盐酸盐,1,2,4,5-Benzenetetramine tetrahydrochlor,FAK Inhibitor 14 |
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) 是一种特异性的粘着斑激酶抑制剂,能够降低其自身磷酸化活性,抑制癌细胞的活力,阻断肿瘤生长。 | |||
T2160 |
Suramin Sodium Salt
苏拉明钠,BAY-205,Suramin hexasodium salt,苏拉明钠盐,NF-060 |
Apoptosis; Phosphatase; SARS-CoV; Sirtuin; Reverse Transcriptase; Topoisomerase; Parasite | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Suramin Sodium Salt (BAY-205) 是可逆的竞争性蛋白酪氨酸磷酸酶抑制剂。它抑制 IP5K,是抗寄生虫,抗肿瘤和抗血管生成剂。它是sirtuins 的有效抑制剂,也是 SARS-CoV-2 RNA 依赖性 RNA 聚合酶抑制剂。 | |||
T21761 |
HNMPA
|
IGF-1R | Tyrosine Kinase/Adaptors |
HNMPA 是膜不可渗透的胰岛素受体酪氨酸激酶 (insulin receptor tyrosine kinase) 抑制剂。HNMPA 可以抑制人胰岛素受体的酪氨酸和丝氨酸自磷酸化。HNMPA 对环 AMP 依赖性蛋白激酶或蛋白激酶 C 活性没有影响。 | |||
T31458 |
DiFMUP
6,8-Difluoro-4-methylumbelliferyl phosphate |
||
DiFMUP (6,8-Difluoro-4-methylumbelliferyl phosphate) 是一种荧光底物,抑制蛋白酪氨酸磷酸酶(PTPs),可用于检测苏氨酸磷酸酶的活性。 | |||
T7381 |
TCS 401
|
Phosphatase | Metabolism |
TCS 401 是一种选择性的蛋白酪氨酸磷酸酶 1B 抑制剂。 | |||
T12578 |
(E,E)-RAMB4
PTP1B-IN-8 |
Phosphatase | Metabolism |
PTP1B-IN-8 is a potent and selective inhibitor of protein tyrosine phosphatase-1B (PTP1B). | |||
T7900 |
BAY-474
|
c-Met/HGFR | Tyrosine Kinase/Adaptors |
BAY-474 是酪氨酸蛋白激酶 c-MET 抑制剂,能够用于表观遗传学探针。 | |||
T7356 |
PTP1B-IN-1
PTP1B inhibitor,5-苯基-1,2,5-噻二唑烷-3-酮 1,1-二氧化物 |
Phosphatase | Metabolism |
PTP1B-IN-1 (PTP1B inhibitor) 是一种蛋白质酪氨酸磷酸酶 1B 的有效抑制剂 (IC50 : 1.6 mM) | |||
T4256 |
PTP1B-IN-2
|
Phosphatase | Metabolism |
PTP1B-IN-2 是一种蛋白酪氨酸磷酸酶抑制剂,IC50=50 nM。 | |||
TP1051L |
Protein Kinase C Peptide Substrate acetate
Protein Kinase C Peptide Substrate acetate(120253-69-2 free base) |
Others | Others |
Protein Kinase C Peptide Substrate acetate(120253-69-2 free base) 以依赖于第二信使和特定衔接蛋白的方式靶向特定细胞间隔物,以响应激活 g 蛋白偶联受体、酪氨酸激酶受体或酪氨酸激酶偶联受体的细胞外信号。 | |||
T4511 |
ST271
ST 271 |
Phospholipase; Tyrosine Kinases | Metabolism; Tyrosine Kinase/Adaptors |
ST271 是蛋白质酪氨酸激酶 (PTK) 抑制剂,抑制 fMet-Leu-Phe 和 PAF 引起的 phospholipase D 活化的IC50值分别为 6.7 和 9 μM。 | |||
T7101 |
Tyrphostin AG30
Tyrphostin AG30(AG30),酪氨酸磷酸化抑制剂 AG 30 |
EGFR; Tyrosine Kinases | Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Tyrphostin AG30 (AG30) 是一种有效的蛋白质酪氨酸激酶 (PTK) 抑制剂,选择性地抑制 c-ErbB 的自我更新诱导,并能抑制原发性红细胞 c-ErbB 激活 STAT5。 | |||
T13013 |
Sodium stibogluconate
Stibogluconate trisodium nonahydrate,葡萄糖酸锑钠 |
Phosphatase | Metabolism |
Sodium stibogluconate (Stibogluconate trisodium nonahydrate) 是一种有效的蛋白酪氨酸磷酸酶 (phosphatase) 抑制剂。 它在10,100 和 100 μg/mL 时分别抑制 99% 的 SHP-1,SHP-2 和 PTP1B 活性。 | |||
T19498 |
p-Cresyl sulfate potassium
p-Tolyl sulfate potassium salt,p-Cresol sulfate potassium,p-Methylphenyl potassium sulfate,对甲基硫酸钾,Potassium p-tolyl sulfate |
Endogenous Metabolite | Metabolism |
p-Cresyl sulfate potassium (p-Tolyl sulfate potassium salt) 是一种尿毒症毒素,能够与原型蛋白质结合。 | |||
T14841 |
BVT948
|
Phosphatase; P450; Histone Methyltransferase | Chromatin/Epigenetic; Metabolism |
BVT948 是一种蛋白酪氨酸磷酸酶抑制剂,还可以抑制赖氨酸甲基转移酶 SETD8 (KMT5A) 和几种细胞色素 P450 (P450) 同工型。 | |||
T67893 |
PTP1B-IN-22
|
Phosphatase | Metabolism |
PTP1B-IN-22是一种蛋白酪氨酸磷酸酶1B (PTP1B)抑制剂,可抑制骨骼肌 L6肌管的葡萄糖摄取。 | |||
T3211 |
Midostaurin
米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱 |
Others; PKC | Chromatin/Epigenetic; Cytoskeletal Signaling; Others |
Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂,有抗肿瘤活性,对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。 | |||
T10190 |
7-BIA
|
Phosphatase | Metabolism |
7-BIA 是一种受体型蛋白酪氨酸磷酸酶 D (PTPRD) 抑制剂,具有抗抗成瘾作用,可用于研究神经性疼痛。 | |||
T6217 |
LFM-A13
|
PLK; JAK; BTK | Angiogenesis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors |
LFM-A13 是一种 BTK,JAK2,PLK 有效抑制剂,可抑制 BTK、Plx1 和 PLK3 的活性,IC50分别为 2.5、10 和 61 μM。 | |||
T50088 |
N-phenylthiophene-2-carboximidamide
|
Others | Others |
N-phenylthiophene-2-carboximidamide 是一种噻吩衍生物,可以作为蛋白酪氨酸激酶(PTKs)的抑制剂和 G 蛋白偶联受体(GPCR)的配体发挥作用。 | |||
T37184 |
CX08005
2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid |
Phosphatase | Metabolism |
CX08005 是一种蛋白酪氨酸磷酸酶 1B 抑制剂,可减轻与非酒精性脂肪肝相关的肝脏脂质蓄积和微循环障碍。 | |||
T1962 |
ASP3026
ASP 3026 |
Apoptosis; ALK | Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors |
ASP3026 是一种选择性的,具有口服活性的间变性淋巴瘤激酶抑制剂,可诱导肿瘤细胞凋亡,可研究非小细胞肺癌。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1433 |
Batatasin III
|
FAK; Others; Akt | Angiogenesis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭,并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用,显示出抑制萌发活性。 | |||
T5S0761 |
Nitidine chloride
|
Apoptosis; ERK; FAK; p38 MAPK; NF-κB; Topoisomerase; STAT; Parasite | Angiogenesis; Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors |
Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的,具有抗疟疾活性。它通过多个靶点通路,起抗癌作用,抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。 | |||
T3122 |
Fangchinoline
Tetrandrine B,防己诺林碱,(+)-Limacine,Hanfangichin B,防己醇灵,(+)-Fangchinoline |
Apoptosis; FAK; HIV Protease; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Fangchinoline (Tetrandrine B) 是从Stephaniatetrandra 中分离出来的,一种具有广泛生物学活性的天然产物。它是新型HIV-1抑制剂,通过损害 gp160 蛋白水解过程来抑制 HIV-1 复制。它靶向Focal adhesion kinase (FAK)并抑制肿瘤细胞中 FAK 介导的的信号传导途径。 | |||
T1695 |
DL-O-Tyrosine
|
Amino Acids and Derivatives | Metabolism |
DL-O-Tyrosine 是苯丙氨酸的代谢物,是形成儿茶酚胺的前体。它被用作β-地中海贫血中蛋白质氧化损伤的生物标志物。 | |||
TN1096 |
Ginsenoside Ra1
人参皂苷 Ra1,人参皂苷Ra1 |
Others; Tyrosine Kinases | Others; Tyrosine Kinase/Adaptors |
Ginsenoside Ra1 是来自人参的成分。 Ginsenoside Ra1 对缺氧/复氧诱导的蛋白酪氨酸激酶 (PTK) 活化具有显着抑制作用。 | |||
TN1053 |
Aloe-emodin-8-O-β-D-glucopyranoside
Aloe-emodin-8-O-beta-D-glucopyranoside,芦荟大黄素-8-O-β-D-葡萄糖苷 |
Phosphatase | Metabolism |
Aloe-emodin-8-O-β-D-glucopyranoside (Aloe-emodin-8-O-beta-D-glucopyranoside) 是一种分离自Saussrurea lappa 中的化合物,是一种温和的人类蛋白酪氨酸磷酸酶 1B 抑制剂,其IC50=26.6 μM。 | |||
T1737 |
Genistein
NPI 031L,三叶草,染料木素,金雀异黄酮 |
Apoptosis; EGFR; Endogenous Metabolite; Autophagy | Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Tyrosine Kinase/Adaptors |
Genistein (NPI 031L) 是一种大豆异黄酮,是一种多重的酪氨酸激酶抑制剂,通过改变细胞凋亡,细胞周期和血管生成以及抑制转移对多种癌症有化疗作用。 | |||
T6427 |
Butein
2’,3,4,4’-tetrahydroxy Chalcone,紫铆因 |
Apoptosis; EGFR; Others; PDE; Autophagy | Angiogenesis; Apoptosis; Autophagy; JAK/STAT signaling; Metabolism; Others; Tyrosine Kinase/Adaptors |
Butein (2’,3,4,4’-tetrahydroxy Chalcone) 是一种 cAMP 特异性PDE 抑制剂,也是蛋白酪氨酸激酶抑制剂,还是一种SIRT1激活剂。它通过 AKT 和 ERK/p38 MAPK 通路,靶向 FoxO3a 使 HeLa 细胞对 Cisplatin 敏感。 | |||
TN1470 |
Cassiaside B2
决明子苷B2 |
Phosphatase; MAO; 5-HT Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Cassiaside B2 是蛋白酪氨酸磷酸酶1B (PTP1B) 和人单胺氧化酶A (hMAO-A) 的抑制剂。Cassiaside B2是 5-HT2C 受体的激动剂, 具有抗过敏活性。Cassiaside B2 是萘吡喃酮参比提取物(NRE)的有效成分之一。 | |||
TN1440 |
Beta-Hydroxyisovalerylshikonin
|
EGFR; Tyrosine Kinases; Prostaglandin Receptor; Src; AMPK; Fatty Acid Synthase | Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
Beta-hydroxyisovalerylshikonin 是分离自Lithospermium radix 的天然产物,具有抑制PTK 的作用, 对 EGFR 和 v-Src 受体作用的IC50分别为 0.7 μM 和 1 μM。它对多种肿瘤细胞系均有抑制作用,可以高效诱导 NCI-H522 和 DMS114 细胞的死亡。 | |||
TN2019 |
Orobol
3'-Hydroxygenistein,3’,4’,5,7-tetrahydroxy-isoflavon,3',4',5,7-四羟基异黄酮 |
BCL; Caspase; PI3K | Apoptosis; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) 是酪氨酸特异性蛋白激酶和磷脂酰肌醇转换的抑制剂。Orobol 抑制 PI3K,对 PI3K α/β/γ/K/δ 的 IC50 为 3.46-5.27 μM。 Orobol 具有抗皮肤老化和抗肥胖的作用。 | |||
T0610 |
Piceatannol
白皮杉醇,trans-Piceatannol,Astringenin |
Apoptosis; Serine/threonin kinase; PKA; Syk; PKC; Autophagy | Angiogenesis; Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Tyrosine Kinase/Adaptors |
Piceatannol (Astringenin) 是一种Syk 抑制剂,可降低由 TNF 诱导的 iNOS 表达,可研究急性肺损伤。它是存在于各种水果和蔬菜中天然存在的多酚二苯乙烯,可诱导细胞自噬和凋亡,具有抗癌和抗炎特性。 | |||
TN2111 |
Prunin
Naringenin 7-0-glucoside,柚皮素-7-O-葡萄糖苷 |
Phosphatase; Anti-infection; Virus Protease | Metabolism; Microbiology/Virology |
Prunin (Naringenin 7-0-glucoside) 是一种人肠道病毒 A71 抑制剂。它抑制蛋白酪氨酸磷酸酶 1B,IC50值为 5.5 μM。 | |||
T4S0498 |
Glaucocalyxin A
蓝萼甲素,Wangzaozin B,Leukamenin F |
Apoptosis; Akt; Caspase; PI3K | Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜,具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位,诱导骨肉瘤凋亡。 | |||
T4S0878 |
Prunetin
樱黄素,Prunusetin |
ERK; Dehydrogenase; NF-κB | MAPK; Metabolism; NF-κB |
Prunetin (Prunusetin) 是一种O-甲基化异黄酮,具有抗炎的作用。它是人醛脱氢酶的有效抑制剂。 | |||
T3S1612 |
kuwanon G
桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G |
Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂,具有杀菌作用。 | |||
TN5400 |
Aerugidiol
|
||
Aerugidiol inhibits protein tyrosine phosphatase 1B (PTP1B). | |||
T20555 |
Glycyltyrosine
NSC 118362,Gly Tyr,NSC-118362,Gly-Tyr,NSC118362,N-Glycyl-L-tyrosine |
Others | Others |
Glycyltyrosine, a dipeptide composed of tyrosine and glycine, is an incomplete breakdown product of protein catabolism or protein digestion. | |||
T19885 |
Methyllucidone
|
||
Methyllucidone is an inhibitor of STAT3 that acts by regulating the expression of the protein tyrosine phosphatase MEG2. | |||
TN3042 |
4-Hydroxycinnamamide
|
ATPase; EGFR; Potassium Channel; p38 MAPK; Calcium Channel; Sodium Channel; AMPK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors |
4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases. | |||
T39219 |
Ficusonolide
|
Others | Others |
Ficusonolide exhibits significant antidiabetic activity through its interactions with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase. | |||
T13740 |
Isotanshinone IIA
|
Others | Others |
Isotanshinone IIA, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. is an abietane-type diterpene metabolite. | |||
TN3335 |
Abyssinone V
|
Phosphatase | Metabolism |
Abyssinone V 是一种从刺桐茎皮中分离的天然化合物,是蛋白质酪氨酸磷酸酶 1B (PTP1B) 的抑制剂。 | |||
TN2887 |
3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid
|
Phosphatase | Metabolism |
(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM. | |||
T73073 |
PTP1B-IN-21
|
Others | Others |
PTP1B-IN-21 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.56 μM),抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP;IC50>100 μM),PTP1B 是抑制 2 型糖尿病的重要靶点。 | |||
T38587 |
Chrysophanol triglucoside
|
Others | Others |
Chrysophanol triglucoside is an anthraquinone isolated from Cassia obtusifolia , inhibits protein tyrosine phosphatases 1B (PTP1B) and α-glucosidase with IC 50 s of 80.17 and 197.06 μM, respectively. Chrysophanol triglucoside has the potential for diabetes research. | |||
TN3505 | Beta-Peltoboykinolic acid | Phosphatase | Metabolism |
Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cytotoxic activity. | |||
TN2913 |
3-Acetoxy-11-ursen-28,13-olide
|
Phosphatase | Metabolism |
3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line. | |||
T73072 |
PTP1B-IN-20
|
Others | Others |
PTP1B-IN-20 是蛋白酪氨酸磷酸酶 1B (PTP1B) 的选择性抑制剂 (IC50=1.05 μM),抑制力超出高度同源 T 细胞蛋白酪氨酸磷酸酶 (TCPTP;IC50=78.0 μM),PTP1B 是抑制 2 型糖尿病的重要靶点。 | |||
TN1775 |
Isocryptotanshinone
|
ERK; JNK; STAT | JAK/STAT signaling; MAPK; Stem Cells |
Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. | |||
T3827 |
Rhein-8-glucoside calcium
大黄酸-8-O-β-D-葡萄糖苷,Rhein-8-O-β-D-glucopyranoside,Rhein-8-glucoside calcium salt |
Phosphatase; Antibacterial | Metabolism; Microbiology/Virology |
Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt 是一种从 Saussurea lappa 根的 EtOH 提取物中,分离得到的蒽醌类 hPTP1B 抑制剂,IC50值为11.5 μM,具有抗菌作用。 | |||
T38069 |
Aquastatin A
|
Others | Others |
Aquastatin A is a fungal metabolite originally isolated fromF. aquaeductuumthat has diverse biological activities.1It is active againstS. aureus(MIC = 32 μg/ml) and inhibits enoyl-acyl carrier protein reductase (Fabl; IC50= 3.2 μM) andS. aureusfatty acid synthesis (IC50= 3.5 μM).2Aquastatin A also inhibits the Na+/K+-ATPase and H+/K+-ATPase (IC50s = 7.1 and 6.2 μM, respectively), as well as protein tyrosine phosphatase 1B (PTP1B; IC50= 0.19 μM).1,3 1.Hamano, K., Kinoshita-Okami, M., Minagawa, K.... | |||
TN3525 |
Boehmenan
|
ERK; Phosphatase; EGFR; PARP; MEK; Wnt/beta-catenin; Akt; Caspase; STAT; p53 | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors |
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell | |||
T75495 |
Rubrofusarin 6-O-β-D-glucopyranoside
|
Others | Others |
Rubrofusarin 6-O-β-D-glucopyranoside为Rubrofusarin的糖苷形式,具有抑制蛋白酪氨酸磷酸酶 1B (PTP1B) 的活性,IC50值为87.36 μM,适用于糖尿病和抑郁症研究。 | |||
TN4279 |
Isoderrone
|
Tyrosinase | Proteases/Proteasome |
Isoderrone 在体外对α-葡萄糖苷酶(α-glucosidase)有抑制作用;它是一种蛋白酪氨酸磷酸酶1B(PTP1B)抑制剂,IC50值为22.7±1.7μM,表明它可能是一种治疗2型糖尿病的新药。 | |||
T79985 |
Cryptosporioptide A
|
Phosphatase | Metabolism |
Cryptosporioptide A (Compound 3)是一种从昆虫寄生真菌Cordyceps gracilioides中分离出的色素蛋白酪氨酸磷酸酶抑制剂,针对PTP1B、SHP2、CDC25B、LAR和SHP1等酶展示了抑制作用,其IC50值分别为7.3、5.7、7.6、>50、4.9 μg/mL。 | |||
TN2928 |
Pygenic acid A
3-Epicorosolic acid,脓毒酸A |
||
3-Epicorosolic acid has a potent inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) induction, it has potential anti-inflammatory activities as well as cancer chemopreventive activity.3-Epicorosolic acid shows both potent α-glucosidase and pro | |||
T80007 |
Stevisalioside A
|
Phosphatase | Metabolism |
Stevisalioside A (Compound 2),一种从甜叶菊根提取的化合物,展现出抗糖尿病的口服活性。该化合物有效抑制PTP1B,IC50为526.8 μM,并能降低Stevisalioside A引起的高血糖小鼠血糖水平,改善餐后血糖峰值及口服葡萄糖和胰岛素耐量测试结果。 | |||
T36950 |
Rubrofusarin triglucoside
|
Others | Others |
Rubrofusarin triglucoside is a glycoside compound isolated from Cassia obtusifolia Linn seeds. Rubrofusarin triglucoside inhibits human monoamine oxidase A (hMAO-A) with an IC50 of 85.5 μM[1]. [1]. Pradeep Paudel, et al. Rubrofusarin as a Dual Protein Tyrosine Phosphate 1B and Human Monoamine Oxidase-A Inhibitor: An in Vitro and in Silico Study. ACS Omega. 2019 Jul 3;4(7):11621-11630. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00412 |
VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)
Vascular endothelial growth factor receptor 1,Vascular perme... |
Human | HEK293 Cells |
Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas... | |||
TMPH-02271 |
BTK Protein, Human, Recombinant (His)
BPK,AGMX1,ATK,B-cell progenitor kinase,Tyrosine- |
Human | Baculovirus Insect Cells |
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in... | |||
TMPY-04125 |
PTP1B Protein, Human, Recombinant (His)
protein tyrosine phosphatase, non-receptor... |
Human | E. coli |
PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein p... | |||
TMPJ-00778 |
HER2/ERBB2 Protein, Human, Recombinant (His)
TKR1,Metastatic lymph node gene 19 protein,ERBB2,Pr... |
Human | HEK293 Cells |
HER2/ERBB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 90-120 KDa and the accession number is P04626. | |||
TMPY-03484 |
TCPTP Protein, Human, Recombinant
TCPTP,protein tyrosine phosphatase, non-re... |
Human | Baculovirus Insect Cells |
TCPTP Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 36.8 kDa and the accession number is P17706-1. | |||
TMPY-03548 |
PTPN12 Protein, Human, Recombinant
protein tyrosine phosphatase, non-receptor... |
Human | Baculovirus Insect Cells |
PTPN12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.8 kDa and the accession number is AAA36529.1. | |||
TMPY-05308 |
CD45 Protein, Human, Recombinant (aa 1-529, His)
GP180,B220,L-CA,protein tyrosine phosphata... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5. | |||
TMPY-05748 |
CD45 Protein, Human, Recombinant (aa 26-577, His)
L-CA,T200,LCA,B220,protein tyrosine phosph... |
Human | HEK293 Cells |
CD45 Protein, Human, Recombinant (aa 26-577, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 62.2 kDa and the accession number is P08575-3. | |||
TMPJ-01017 |
Dtk Protein, Mouse, Recombinant (hFc)
tyro3,Tyrosine-protein kinase receptor TYR... |
Mouse | HEK293 Cells |
Dtk Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is P55144. | |||
TMPJ-01081 |
Dtk Protein, Human, Recombinant (His)
RSE,SKY,DTK,Tyrosine-protein kinase DTK, |
Human | HEK293 Cells |
Axl (Ufo, Ark), Dtk (Sky, Tyro3, Rse, Brt) and Mer (human and mouse homologues of chicken cEyk)constitute a new receptor tyrosine kinase subfamily. The extracellular domain of these proteins contain two Ig-like motifs and two fibronectin type III motifs. This characteristic topology is also found in neural cell adhesion molecules and in receptor tyrosine phosphatases. All three receptors bind the vitamin K-dependent protein growth-arrest specific gene 6 (Gas6) which is structurally related to th... | |||
TMPJ-01018 |
Dtk Protein, Mouse, Recombinant (mFc)
TK19-2,Tyrosine-protein kinase RSE,Etk2/ty... |
Mouse | HEK293 Cells |
Dtk Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 60-90 KDa and the accession number is P55144. | |||
TMPY-04377 |
Brk Protein, Human, Recombinant (GST)
BRK,protein tyrosine kinase 6 |
Human | Baculovirus Insect Cells |
Brk Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 78 kDa and the accession number is Q13882-1. | |||
TMPJ-00465 |
PTP1C Protein, Human, Recombinant (His)
HCP,Hematopoietic Cell Protein-Tyrosine Ph... |
Human | E. coli |
Protein-Tyrosine Phosphatase 1C (PTP1C) belongs to the protein-tyrosine phosphatase family.which is known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1C is highly expressed in leukocyte cell type. It contains two SH2 domains and one tyrosine-protein phosphatase domain. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against inter... | |||
TMPH-02278 |
PTPN5 Protein, Human, Recombinant (His & SUMO)
PTPN5,Neural-specific protein-tyrosine pho... |
Human | E. coli |
May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. PTPN5 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.5 kDa and the accession number is P54829. | |||
TMPH-02277 |
PTPN11 Protein, Human, Recombinant (T253M & Q257L, His)
Protein-tyrosine phosphatase 1D,Tyrosi... |
Human | E. coli |
Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification. | |||
TMPH-02011 |
PTPRB Protein, Human, Recombinant (His & SUMO)
PTPRB,Receptor-type tyrosine-protein phosp... |
Human | E. coli |
PTPRB Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-02010 |
PTPRB Protein, Human, Recombinant (His)
Vascular endothelial protein tyrosine phos... |
Human | P. pastoris (Yeast) |
PTPRB Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPH-02790 |
MUSK Protein, Mouse, Recombinant (His & Myc & SUMO)
Muscle-specific tyrosine-protein kinase re... |
Mouse | E. coli |
MUSK Protein, Mouse, Recombinant (His & Myc & SUMO) is expressed in E. coli. | |||
TMPJ-00449 |
AXL Protein, Human, Recombinant (hFc)
UFO,Tyrosine-protein kinase receptor UFO,A... |
Human | HEK293 Cells |
AXL Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-115 KDa and the accession number is AAA61243. | |||
TMPH-01718 |
MUSK Protein, Human, Recombinant (His)
Muscle, skeletal receptor tyrosine-protein... |
Human | P. pastoris (Yeast) |
MUSK Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 53.8 kDa and the accession number is O15146. | |||
TMPJ-00399 |
AXL Protein, Mouse, Recombinant (hFc)
Tyrosine-protein kinase receptor UFO,UFO,A... |
Mouse | HEK293 Cells |
AXL Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 85-120 KDa and the accession number is Q00993. | |||
TMPY-04440 |
Brk Protein, Mouse, Recombinant (His & GST)
BRK,Tksk,protein tyrosine kinase 6,tks,Sik |
Mouse | Baculovirus Insect Cells |
Brk Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 79.8 kDa and the accession number is Q64434. | |||
TMPH-03719 |
YopH Protein, Yersinia enterocolitica, Recombinant (His & Myc)
yopH,Virulence protein,Tyrosine-protei... |
Yersinia enterocolitica | E. coli |
Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages. | |||
TMPJ-01143 |
MERTK/Mer Protein, Human, Recombinant (aa 1-323, His)
MER,Receptor tyrosine kinase MerTK,Tyrosine |
Human | HEK293 Cells |
Tyrosine-protein kinase Mer (MERTK) is a single-pass type I membrane protein which belongs to the MER/AXL/TYRO3 receptor kinase family. MERTK include two fibronectin type-III domains, two Ig-like C2-type domains, and one tyrosine kinase domain. It can’t be expressed in normal B- and T-lymphocytes, but it is usually expressed in numerous neoplastic B- and T-cell lines. MERTK could regulate many physiological processes, such as cell survival, migration, differentiation. It was demonstrated that t... | |||
TMPH-02275 |
Lck Protein, Human, Recombinant (His)
Proto-oncogene Lck,T cell-specific protein-tyro... |
Human | E. coli |
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules... | |||
TMPH-02987 |
PTPRS Protein, Mus musculus, Recombinant (His & Myc)
Ptprs,Receptor-type tyrosine-protein phosp... |
Mouse | Baculovirus Insect Cells |
PTPRS Protein, Mus musculus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 35.8 kDa and the accession number is B0V2N1. | |||
TMPH-02013 |
PTPRZ1 Protein, Human, Recombinant (His)
Protein-tyrosine phosphatase receptor type... |
Human | P. pastoris (Yeast) |
Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades. PTPRZ1 Protein, Human, Recombinant (His) is exp... | |||
TMPJ-01085 |
DPT Protein, Human, Recombinant (hFc & His)
TRAMP and DPT,Tyrosine-rich acidic matrix prote... |
Human | HEK293 Cells |
Dermatopontin, also known as Tyrosine-rich acidic matrix protein, TRAMP and DPT, is a secreted protein which belongs to the dermatopontin family. DPT is expressed in various tissues, such as fibroblasts, heart, skeletal muscle, brain and pancreas. It seems to mediate adhesion by cell surface integrin binding. DPT may serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. DPT can enhance TGFB1 activity through interaction with decorin. ... | |||
TMPJ-00053 |
PRL-2 Protein, Human, Recombinant (His)
HU-PP-1,Protein tyrosine phosphatase type ... |
Human | E. coli |
PTP4A2, also known as PRL2 or PTPCAAX2, is short for Protein tyrosine phosphatase type IVA 2. This protein exists in cell membrane, cytoplasm,endosome and membrane. PTP4A2 is often farnesylated during post-translational modification. Farnesylation is required for membrane targeting and for interaction with RABGGTB. The unfarnesylated forms are redirected to the nucleus and cytosol. It can stimulate progression from G1 into S phase during mitosis and promotes tumors. It also inhibits geranylgeran... | |||
TMPH-02878 |
PTPRS Protein, Mouse, Recombinant (His & Myc)
Receptor-type tyrosine-protein phosphatase... |
Mouse | E. coli |
Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteo... | |||
TMPH-02012 |
PTPRZ1 Protein, Human, Recombinant (E. coli, His)
Protein-tyrosine phosphatase receptor type... |
Human | E. coli |
PTPRZ1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli. | |||
TMPJ-01369 |
DPT Protein, Mouse, Recombinant (hFc)
EQ-1,Early quiescence protein 1,TRAMP,Tyrosine<... |
Mouse | HEK293 Cells |
Dermatopontin is a widely expressed noncollagenous protein component of the extracellular matrix. It is a 22 kDa molecule that is tyrosine sulfated but not glycosylated. Dermatopontin is down regulated in fibrotic growths such as leiomyoma and scar tissue, inhibits cell proliferation, accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation, Dermatopontin deficient mice exhibit altered collagen matrix deposition and organization. Dermatopontin s... | |||
TMPJ-00307 |
BLK Protein, Human, Recombinant (His)
Tyrosine-Protein Kinase Blk,BLK,B Lymphocy... |
Human | E. coli |
Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B t... | |||
TMPY-02584 |
14-3-3 beta Protein, Cynomolgus, Recombinant
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase... |
Cynomolgus | E. coli |
14-3-3 beta Protein, Cynomolgus, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 27.8 kDa and the accession number is Q4R572-2. | |||
TMPH-01777 |
TYK2 Protein, Human, Recombinant (E. coli, His)
TYK2,Non-receptor tyrosine-protein kinase ... |
Human | E. coli |
TYK2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.9 kDa and the accession number is P29597. | |||
TMPH-01778 |
TYK2 Protein, Human, Recombinant (His)
Non-receptor tyrosine-protein kinase TYK2,... |
Human | Baculovirus Insect Cells |
TYK2 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 34.4 kDa and the accession number is P29597. | |||
TMPJ-00808 |
CD45RA Protein, Human, Recombinant (His)
PTPRC,CD45R,CD45,LCA,protein tyrosine phos... |
Human | HEK293 Cells |
CD45RA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 100-135 KDa and the accession number is P08575-8. | |||
TMPJ-00794 |
CD45 Protein, Mouse, Recombinant (His)
CD45,receptor-type tyrosine-protein phosph... |
Mouse | HEK293 Cells |
CD45 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 120-160 KDa and the accession number is P06800. | |||
TMPH-02961 |
JAK1 Protein, Mouse, Recombinant (His)
Janus kinase 1,Jak1,Tyrosine-protein kinas... |
Mouse | E. coli |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. JAK1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.1 kDa and the accession numb... | |||
TMPH-01938 |
PRKCD Protein, Human, Recombinant (His)
Tyrosine-protein kinase PRKCD,PRKCD,Pr... |
Human | E. coli |
PRKCD Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPJ-00410 |
CD45R0 Protein, Human, Recombinant (His)
CD45 antigen,L-CA,protein tyrosine phospha... |
Human | HEK293 Cells |
CD45R0 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 80-120 KDa and the accession number is P08575-4. | |||
TMPY-00487 |
PTPN9 Protein, Human, Recombinant (His & GST)
PTPMEG2,protein tyrosine phosphatase, non-... |
Human | Baculovirus Insect Cells |
Protein tyrosine phosphatase non-receptor type 9 (PTPN9), also named PTP-MEG2, is an important member of the protein tyrosine phosphatase family that is involved in variety of human diseases.PTPN9 plays an important role in erythropoiesis by disrupting an inhibitory complex of phosphorylated STAT3, GATA1 and ZBP-89, providing new cellular and molecular insights into the role of ptpn9a in developmental hematopoiesis. | |||
TMPY-02378 |
14‑3‑3 theta/YWHAQ Protein, Human, Recombinant (GST)
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase... |
Human | E. coli |
The recently identified 14-3-3 tau, whose corresponding gene name is YWHAQ, is in a hypoxia-treated human trophoblast cell line. YWHAQ may play a role in epigenetic regulation of placental genes in the onset of Preeclampsia (PE). Moreover, there was a closer relationship between blood pressure and methylation levels of the YWHAQ promoter. | |||
TMPH-02274 |
JAK2 Protein, Human, Recombinant (His)
JAK2,Janus kinase 2,Tyrosine-protein kinas... |
Human | E. coli |
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple int... | |||
TMPH-02273 |
JAK1 Protein, Human, Recombinant (His)
JAK1,Janus kinase 1,Tyrosine-protein kinas... |
Human | P. pastoris (Yeast) |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. | |||
TMPH-02272 |
JAK1 Protein, Human, Recombinant (E. coli, His)
Tyrosine-protein kinase JAK1,JAK1,Janus ki... |
Human | E. coli |
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Directly phosphorylates STAT but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors. | |||
TMPY-02369 |
TCPTP Protein, Mouse, Recombinant (aa 2-314, His)
protein tyrosine phosphatase, non-receptor... |
Mouse | Baculovirus Insect Cells |
TCPTP Protein, Mouse, Recombinant (aa 2-314, His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 38.7 kDa and the accession number is Q06180-1. | |||
TMPJ-00405 |
EphA4 Protein, Human, Recombinant (hFc)
Ephrin type-A receptor 4,SEK,hEK8,TYRO1,Tyrosine- |
Human | HEK293 Cells |
EphA4 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 90-120 KDa and the accession number is P54764. | |||
TMPY-02179 |
14-3-3 epsilon Protein, Mouse, Recombinant (GST)
AU019196,tyrosine 3-monooxygenase/tryptophan 5-mono... |
Mouse | E. coli |
14-3-3 epsilon Protein, Mouse, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 56.1 kDa and the accession number is P62259. | |||
TMPJ-00404 |
EphA4 Protein, Human, Recombinant
Ephrin type-A receptor 4,TYRO1,HEK8,EK8,EPH-like kinase 8,SE... |
Human | HEK293 Cells |
EphA4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 60-80 KDa and the accession number is P54764. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMID-0096 |
P-CRESOL-d3 (METHYL-d3)
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P-CRESOL-d3 (METHYL-d3) 是 P-CRESOL 的氘代化合物。P-CRESOL 的 CAS 号为 106-44-5。p-Cresol 是一种部分亲脂性部分,在正常条件下与血浆蛋白(接近 100%)强烈结合。对甲酚通过结合代谢,主要是硫酸化和葡萄糖醛酸化,但未结合的对甲酚至少部分通过尿液去除。 |