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223

抑制剂 & 化合物

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Cat. No. Product Name
L1720 核苷类化合物库

334 compounds
334 种核苷类化合物,包括核苷酸、核苷酸类似物及衍生物等,适用于抗病毒、抗肿瘤、抗真菌、抗抑郁等药物的研发;

化合物库

核苷类化合物库
Cat.No: L1720
Compounds: 334
Cat. No. Product Name Target Signaling Pathways
T21195 AICAR monophosphate

Aica ribonucleotide,AICA riboside,Acadesine 5'-monophosphate,Z-nucleotide

Others Others
AICAR monophosphate (Aica ribonucleotide) 是一种具有抗肿瘤活性的嘌呤前体,可用于 2 型糖尿病的研究。
T6357 (S)-crizotinib

ent-crizotinib

Apoptosis; DNA/RNA Synthesis; MTH1 Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
(S)-crizotinib (ent-crizotinib) 是一种选择性MTH1(mutT 同源物)抑制剂,IC50为 330 nM。它通过抑制 MTH1 破坏核苷酸库的稳态,诱导 DNA 单链断裂的增加,激活人结肠癌细胞的 DNA 修复,在动物模型中抑制肿瘤生长。
T9341 Bemnifosbuvir

AT-511

Others; HCV Protease; SARS-CoV Microbiology/Virology; Others; Proteases/Proteasome
Bemnifosbuvir (AT-511) 是一种口服活性抑制剂,抑制 HCV 病毒复制,具有全基因型抗病毒活性。它有效抑制 SARS-CoV-2 (COVID-19)感染 (EC90=0.47 μM)。
T9331 Bemnifosbuvir hemisulfate

AT-527

HCV Protease; SARS-CoV Microbiology/Virology; Proteases/Proteasome
Bemnifosbuvir hemisulfate (AT-527) 是一种 HCV 病毒复制抑制剂。
T40192 dGTP

2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate

Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
dGTP(2'-Deoxyguanosine-5'-triphosphate)作为脱氧核糖核酸(DNA)合成的基本单元,属于鸟苷核苷酸,对8-O-GDP、8-O-dGTP、8-O-GTP及8-O-dGTP的氧化损伤具有高度敏感性。
T1675 Adefovir dipivoxil

Hepsera,GS 0840,阿德福韦酯,Preveon

Others; HBV; Reverse Transcriptase Microbiology/Virology; Others
Adefovir dipivoxil (GS 0840) 是一种腺苷类似物,是核苷逆转录酶抑制剂 Adefovir 的口服前药,具有抗乙型肝炎病毒、疱疹病毒和人类免疫缺陷病毒的活性。
T2923 Apremilast

阿普斯特,CC-10004,阿普司特

Apoptosis; TNF; PDE Apoptosis; Metabolism
Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 抑制剂,IC50为 74 nM。它抑制脂多糖释放TNF-α,IC50为 104 nM。
T2535 Ivabradine hydrochloride

盐酸伊伐布雷定,S 16257-2,Ivabradine HCl

Adrenergic Receptor GPCR/G Protein; Neuroscience
Ivabradine hydrochloride (S 16257-2) 是一种可口服的,超极化激活的环核苷酸门控离子通道通道阻滞剂。
T7516 ZD7288

N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐,ICI D7288

HCN Channel Membrane transporter/Ion channel
ZD7288 (ICI D7288) 是一种选择性超极化激活的环核苷酸门控通道阻滞剂,可抑制海马突触可塑性。
T3280 Clodronate disodium tetrahydrate

clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium

IL Receptor; TNF Apoptosis; Immunology/Inflammation
Clodronate disodium tetrahydrate (Clastoban) 是一种选择性、高效的,可逆、Cl-竞争性的囊泡核苷酸转运体阻滞剂(IC50:15.6 nM)。是一种双膦酸盐,具有抗骨质疏松、抗炎作用,可用于缓解疼痛的研究。它可抑制神经元释放囊泡 ATP,缓解慢性神经病理性疼痛和炎症性疼痛。
T8855 Polydeoxyribonucleotide(Sodium salt)

Polydeoxyribonucleotide from salmon

Others Others
Polydeoxyribonucleotide(Sodium salt) 可改善大鼠跟腱损伤模型中各种生长因子的分泌,促进胶原蛋白合成,恢复跟腱的拉伸强度。
T77253 β-Nicotinamide adenine dinucleotide reduced dipotassium

Others Others
β-Nicotinamide adenine dinucleotide reduced dipotassium 作为一种口服有效的还原型辅酶,在ADP-核糖基转移酶反应中担任ADP-核糖单元的供体及环状ADP-核糖的前体。该化合物在细胞能量代谢,包含糖酵解、β-氧化及三羧酸(TCA)循环中,发挥重要的再生电子供体角色。
T78408 Nicotinamide 1,N6-ethenoadenine dinucleotide

ε-NAD

Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) 是一种NAD的荧光类似物,它可作为底物参与细菌毒素催化的信号转导G蛋白G-ADP核糖基化反应。此外,ε-NAD还常用作ADP核糖基化反应研究的荧光底物。
T64590 Flavin Adenine Dinucleotide DiSodium Salt xhydrate

Others Others
Flavin Adenine Dinucleotide DiSodium Salt xhydrate 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64590。
T23969 DCAI

Others Others
DCAI 是一种核苷酸交换和核苷酸释放的抑制剂,通过与 Ras-SOS 界面附近的口袋结合而起作用。
T19214 Bredinin aglycone

5-Hydroxy-1H-imidazole-4-carboxamide,5-羟基-1H-咪唑-4-甲酰胺,SM-108

Others Others
Bredinin aglycone 是嘌呤核苷酸类似物,可用于嘌呤核苷酸类似物催化剂的制作效率的检测 。
T12814 (S)-Tenofovir

(S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF

Others Others
(S)-Tenofovir ((S)-PMPA) 是Tenofovir 的活性较低的S-对映体,Tenofovir 是一种核苷酸逆转录酶抑制剂。
T16716 Rabacfosadine

VDC-1101,GS-9219

Nucleoside Antimetabolite/Analog Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Rabacfosadine (GS-9219) 是向肿瘤淋巴细胞的无环核苷酸膦酸 PMEG 的新型双前药,可用于研究淋巴瘤。
T22592 ATPγS tetralithium salt

ATP-gamma-S tetralithium salt

PERK Apoptosis
ATPγS tetralithium salt 是真核生物翻译起始因子 eIF4A 的核苷酸水解和RNA解链活性的底物,与 p97 突变体和朊病毒相关。
T3587 NOD-IN-1

Compound 4

NOD-like Receptor (NLR); NOD Immunology/Inflammation; NF-κB
NOD-IN-1 (Compound 4) 是核苷酸结合寡聚化结构域样受体 NOD1(IC50:5.74 μM)和 NOD2 (IC50:6.45 μM)的抑制剂。
T2409 Tenofovir alafenamide

替诺福韦艾拉酚胺,替诺福韦,GS-7340

HIV Protease; Reverse Transcriptase Microbiology/Virology; Proteases/Proteasome
Tenofovir alafenamide (GS-7340) 是一种核苷酸逆转录酶抑制剂和抗逆转录病毒替诺福韦的新型酯类前药。
T13995 1-Methyl-7-nitroisatoic anhydride

1M7

Others Others
1-Methyl-7-nitroisatoic anhydride (1M7) 是一种能够检测局部核苷酸的试剂。
T7111 Tenofovir Disoproxil

替诺福韦酯,GS 4331,Bis(POC)-PMPA

HBV; HIV Protease; Reverse Transcriptase Microbiology/Virology; Proteases/Proteasome
Tenofovir Disoproxil (GS 4331) 是一种核苷酸逆转录酶抑制剂,用于治疗 HIV 和慢性乙型肝炎。
T67817 Besifovir PM

LB80331 PM

HBV Microbiology/Virology
Besifovir PM (LB80331 PM) 是Besifovir 的类似物。Besifovir 是一种新型可口服的无环核苷酸膦酸酯,可治疗慢性乙型肝炎感染。
T7282 Tenofovir alafenamide hemifumarate

GS-7340 (hemifumarate),Tenofovir alafenamide fumarate,替诺福韦艾拉酚胺富马酸盐

HIV Protease; Reverse Transcriptase Microbiology/Virology; Proteases/Proteasome
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) 是 HIV 逆转录酶核苷酸抑制剂替诺福韦的口服膦酰胺前药。
T7558 CID-1067700

2-[[(苯甲酰基氨基)硫代甲酰]氨基]-4,7-二氢-5,5-二甲基-5H-噻吩并[2,3-C]吡喃-3-羧酸

Ras GPCR/G Protein; MAPK
CID-1067700 是泛 GTPase 抑制剂,可竞争性抑制 Ras-related in brain 7 (Rab7) 中的 Ras 相关蛋白,Ki 为 13 nM。
T63290 (R,1R)-Tenofovir amibufenamide

(R,1R)-HS-10234

Antiviral Immunology/Inflammation
(R,1R)-Tenofovir amibufenamide ((R,1R)-HS-10234) 可用于 Tenofovir 前药,可口服,具有抗病毒活性。Tynofovir 是一种核苷酸逆转录酶抑制剂。
T35648 4-Thiouridine

Others Others
4-Thiouridine (4-TU) 是一种光活化核糖核苷类似物,广泛用于RNA 分析。
T74041 GDP-L-fucose

Endogenous Metabolite Metabolism
GDP-L-fucose 是一种广泛存在与真菌和植物中的核苷酸糖,参与从头代谢途径和次要的补救代谢途径。
T2244 ESI-09

cAMP; Virus Protease GPCR/G Protein; Microbiology/Virology
ESI-09是一种新型非环状核苷酸EPAC 的拮抗剂,对EPAC1和EPAC2的IC50值分别为3.2和1.4 μM。
T19596 UDP-GlcNAc Disodium Salt

Uridine 5′-diphospho-N-acetylglucosamine,5′-二磷酸尿嘧啶核苷-N-乙酰半乳糖胺二钠盐,UDP-α-D-N-Acetylglucosamine Disodium Salt

Others Others
UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) 是一种 O-GlcNAc 转移酶 (OGT) 的供体底物。
T12569L PSB-12379 ditriethylamine salt

CD73 Immunology/Inflammation
PSB-12379 ditriethylamine salt 是一种核苷酸类似物,是一种有效的 Ecto-5'-Nucleotidase (CD73) 抑制剂,Kis 值为 9.03 nM (鼠) 和 2.21 nM (人)。
T24154 I942

I 942,I-942

cAMP GPCR/G Protein
I942 是一种新型且具有选择性的非环核苷酸 (NCN) EPAC1 激动剂,可激活交换蛋白调节人脐血管中的炎症基因表达,可抑制与心血管疾病相关的促炎细胞因子信号传导。
T19706 Ro 20-1724

Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724

PDE Metabolism
Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) 是 cAMP 特异性磷酸二酯酶抑制剂 b>(PDE4/PDE IV),其 Ki=1930 nM,具有神经保护作用。
T10509 Xanthine oxidase-IN-1

4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid

Xanthine Oxidase Metabolism
Xanthine oxidase-IN-1是一种有效的黄嘌呤氧化酶抑制剂(IC50值:6.5 nM),是一种利用核酸和核苷酸介质降解产生的生物活性核苷酸在嘌呤分解代谢中起核心作用的化合物,
T22680 CP-100356 hydrochloride

CP-100356 HCl,CP 100356 hydrochloride

BCRP Membrane transporter/Ion channel
CP-100356 hydrochloride 是一种具有口服活性和低微摩尔的 MDR1 (P-gp) 和 BCRP 双重抑制剂,是核苷酸衍生的底物类似物,对 MDR1 介导的 Calcein-AM 转运 和 BCRP 介导的 Prazosin 转运有抑制作用。CP-100356 抑制 OATP1B1,可在黑暗中诱导气孔张开。
T60109 Protein kinase inhibitor H-7

5-(2-methylpiperazine-1-sulfonyl)isoquinoline,蛋白激酶抑制剂H-7,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine

PKC Chromatin/Epigenetic; Cytoskeletal Signaling
Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) 是有效的蛋白激酶 C (PKC) 和环核苷酸依赖性蛋白激酶抑制剂,抑制 PKC 的 Ki 值为 6 μM。
T33762 Fosifloxuridine nafalbenamide

NUC-3373,NUC3373,NUC 3373

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Fosifloxuridine nafalbenamide (NUC 3373) 是一种胸腺嘧啶合酶抑制剂,属于嘧啶核苷酸类似物,具有抗癌活性。它能诱发宿主免疫反应,有潜力增强免疫治疗。
T8798 MSA-2

STING Immunology/Inflammation
MSA-2 是可口服的非核苷酸 STING 激动剂,以具有纳摩尔亲和力的非共价二聚体形式与 STING 结合。它在同基因小鼠肿瘤模型中显示抗肿瘤活性,与抗 PD-1 协同作用,可刺激肿瘤分泌干扰素-β,诱导肿瘤消退,具有持久的抗肿瘤免疫。
TQ0002 A-317491

ABT 202

P2X Receptor Membrane transporter/Ion channel; Neuroscience
A-317491 (ABT 202) 是选择性和非核苷酸的 P2X3和 P2X2/3受体的拮抗剂,通过阻断 P2X3和 P2X2/3受体介导的钙通量减轻炎性和神经性疼痛。它对其他 P2 受体和神经递质受体,离子通道以及酶具有高度选择性,IC50大于10 μM。
T4132 BPTU

BMS-646786

P2Y Receptor GPCR/G Protein; Neuroscience
BPTU (BMS-646786) 是一种非核苷酸类P2Y1受体变构拮抗剂,能够阻断位于胃肠道神经肌肉接头的 P2Y1受体,具有抗血栓活性。
T28946 Tenofovir exalidex

Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157

Antiviral Immunology/Inflammation
Tenofovir exalidex (CMX 157) 是一种非环核苷酸类似物 Tenofovir 的脂质结合物,对野生型和抗逆转录病毒耐药的 HIV 毒株,包括多药核苷/核苷酸类似物耐药病毒,都有活性。Tenofovir exalidex 对人外周血单个核细胞中所有主要的HIV-1和HIV-2亚型以及单核细胞来源的巨噬细胞中所有 HIV-1 菌株具有活性,EC50 范围在 0.2 和 7.2 nM 之间。Tenofovir exalidex 具有口服活性,无明显毒性。Tenofovir exalidex 对 HBV 也有活性。
T36688 Deoxyguanosine triphosphate trisodium salt

Deoxyguanosine 5-triphosphate,2'-Deoxyguanosine-5'-triphosphate trisodium salt,dGTP trisodium salt

Nucleoside Antimetabolite/Analog Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Deoxyguanosine triphosphate trisodium salt (2'-Deoxyguanosine-5'-triphosphate trisodium salt) 是细胞中用于 DNA 合成的核苷酸前体,可用于逆转录聚合酶链反应 (RT-PCR) 中以进行 DNA 扩增。
T60904 ERCC1-XPF-IN-2

Others Others
ERCC1-XPF-IN-2 在核苷酸切除修复、顺铂增强和 γH2AX 测定中具有活性。ERCC1-XPF-IN-2 是 ERCC1-XPF 核酸内切酶的有效抑制剂,IC50值为 0.6 μM。
T85309 VVD-214

Others Others
VVD-214 是一种强效、选择性、共价变构的 WRN 解旋酶抑制剂。它以核苷酸协同的方式共价结合 WRN 的半胱氨酸 727,抑制 ATP 水解和解旋酶活性。
T38361 GSK717

IL Receptor; NOD Immunology/Inflammation; NF-κB
GSK717 是 NOD2(核苷酸结合寡聚结构域 2) 的选择性抑制剂。它抑制壁酰二肽 (MDP) 诱导的 NOD2 介导的信号转导,抑制 MDP 刺激的 HEK293/hNOD2 细胞分泌 IL-8 (IC50为 400 nM)。
T80548 mSIRK

ERK MAPK
mSIRK (G-Protein βγ Binding Peptide) 为细胞渗透性ERK1/2激活剂,EC50值介于2.5-5 μM。该化合物干扰α与βγ亚基相互作用,并促进α亚基解离,但不促进核苷酸交换。
T23164 PIT

2,2'-Pyridylisatogen tosylate

P2Y Receptor GPCR/G Protein; Neuroscience
PIT (2,2'-Pyridylisatogen tosylate) 是嘌呤能受体 P2Y1 的特异性非竞争性拮抗剂,对人 P2Y1 的 IC50 为 0.14 μM。 PIT 不影响核苷酸结合,可用于慢性支气管炎和哮喘的研究。
T2627 Nolatrexed dihydrochloride

盐酸诺拉曲塞,Thymitaq,AG 337

DNA/RNA Synthesis Cell Cycle/Checkpoint; DNA Damage/DNA Repair
Nolatrexed dihydrochloride (Thymitaq) 是一种非竞争性的胸苷酸合酶抑制剂,能够在癌细胞 S 期诱导细胞周期停滞,具有抗癌活性。它与该酶的叶酸辅因子结合位点相互作用,对人胸苷酸合酶的Ki 值为 11 nM。
T8930 CID44216842

KUC103479N-02

CDK; Ras Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
CID44216842 (KUC103479N-02) 是Cdc42选择性抑制剂。在 GDP 结合测定中,它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 0.3 和 0.5 μM。在 GTP 结合测定中,它对 Cdc42 野生型和 Cdc42Q61L 突变型的EC50分别为 1.0 和 1.2 μM。它可用作分子探针。

化合物

AICAR monophosphate
Cat.No: T21195
Synonym: Aica ribonucleotide,AICA riboside,Acadesine 5'-monophosphate,Z-nucleotide
Target: Others
(S)-crizotinib
Cat.No: T6357
Synonym: ent-crizotinib
Target: Apoptosis, DNA/RNA Synthesis, MTH1
Bemnifosbuvir
Cat.No: T9341
Synonym: AT-511
Target: Others, HCV Protease, SARS-CoV
Bemnifosbuvir hemisulfate
Cat.No: T9331
Synonym: AT-527
Target: HCV Protease, SARS-CoV
dGTP
Cat.No: T40192
Synonym: 2′-脱氧鸟苷 5′-(四氢三磷酸酯),2'-Deoxyguanosine-5'-triphosphate
Target: Nucleoside Antimetabolite/Analog, DNA/RNA Synthesis
Adefovir dipivoxil
Cat.No: T1675
Synonym: Hepsera,GS 0840,阿德福韦酯,Preveon
Target: Others, HBV, Reverse Transcriptase
Apremilast
Cat.No: T2923
Synonym: 阿普斯特,CC-10004,阿普司特
Target: Apoptosis, TNF, PDE
Ivabradine hydrochloride
Cat.No: T2535
Synonym: 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl
Target: Adrenergic Receptor
ZD7288
Cat.No: T7516
Synonym: N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐,ICI D7288
Target: HCN Channel
Clodronate disodium tetrahydrate
Cat.No: T3280
Synonym: clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium
Target: IL Receptor, TNF
Polydeoxyribonucleotide(Sodium salt)
Cat.No: T8855
Synonym: Polydeoxyribonucleotide from salmon
Target: Others
β-Nicotinamide adenine dinucleotide reduced dipotassium
Cat.No: T77253
Synonym:
Target: Others
Nicotinamide 1,N6-ethenoadenine dinucleotide
Cat.No: T78408
Synonym: ε-NAD
Target:
Flavin Adenine Dinucleotide DiSodium Salt xhydrate
Cat.No: T64590
Synonym:
Target: Others
DCAI
Cat.No: T23969
Synonym:
Target: Others
Bredinin aglycone
Cat.No: T19214
Synonym: 5-Hydroxy-1H-imidazole-4-carboxamide,5-羟基-1H-咪唑-4-甲酰胺,SM-108
Target: Others
(S)-Tenofovir
Cat.No: T12814
Synonym: (S)-替诺福韦,(S)-PMPA,(S)-GS 1278,(S)-TDF
Target: Others
Rabacfosadine
Cat.No: T16716
Synonym: VDC-1101,GS-9219
Target: Nucleoside Antimetabolite/Analog
ATPγS tetralithium salt
Cat.No: T22592
Synonym: ATP-gamma-S tetralithium salt
Target: PERK
NOD-IN-1
Cat.No: T3587
Synonym: Compound 4
Target: NOD-like Receptor (NLR), NOD
Tenofovir alafenamide
Cat.No: T2409
Synonym: 替诺福韦艾拉酚胺,替诺福韦,GS-7340
Target: HIV Protease, Reverse Transcriptase
1-Methyl-7-nitroisatoic anhydride
Cat.No: T13995
Synonym: 1M7
Target: Others
Tenofovir Disoproxil
Cat.No: T7111
Synonym: 替诺福韦酯,GS 4331,Bis(POC)-PMPA
Target: HBV, HIV Protease, Reverse Transcriptase
Besifovir PM
Cat.No: T67817
Synonym: LB80331 PM
Target: HBV
Tenofovir alafenamide hemifumarate
Cat.No: T7282
Synonym: GS-7340 (hemifumarate),Tenofovir alafenamide fumarate,替诺福韦艾拉酚胺富马酸盐
Target: HIV Protease, Reverse Transcriptase
CID-1067700
Cat.No: T7558
Synonym: 2-[[(苯甲酰基氨基)硫代甲酰]氨基]-4,7-二氢-5,5-二甲基-5H-噻吩并[2,3-C]吡喃-3-羧酸
Target: Ras
(R,1R)-Tenofovir amibufenamide
Cat.No: T63290
Synonym: (R,1R)-HS-10234
Target: Antiviral
4-Thiouridine
Cat.No: T35648
Synonym:
Target: Others
GDP-L-fucose
Cat.No: T74041
Synonym:
Target: Endogenous Metabolite
ESI-09
Cat.No: T2244
Synonym:
Target: cAMP, Virus Protease
UDP-GlcNAc Disodium Salt
Cat.No: T19596
Synonym: Uridine 5′-diphospho-N-acetylglucosamine,5′-二磷酸尿嘧啶核苷-N-乙酰半乳糖胺二钠盐,UDP-α-D-N-Acetylglucosamine Disodium Salt
Target: Others
PSB-12379 ditriethylamine salt
Cat.No: T12569L
Synonym:
Target: CD73
I942
Cat.No: T24154
Synonym: I 942,I-942
Target: cAMP
Ro 20-1724
Cat.No: T19706
Synonym: Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724
Target: PDE
Xanthine oxidase-IN-1
Cat.No: T10509
Synonym: 4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid
Target: Xanthine Oxidase
CP-100356 hydrochloride
Cat.No: T22680
Synonym: CP-100356 HCl,CP 100356 hydrochloride
Target: BCRP
Protein kinase inhibitor H-7
Cat.No: T60109
Synonym: 5-(2-methylpiperazine-1-sulfonyl)isoquinoline,蛋白激酶抑制剂H-7,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine
Target: PKC
Fosifloxuridine nafalbenamide
Cat.No: T33762
Synonym: NUC-3373,NUC3373,NUC 3373
Target: DNA/RNA Synthesis
MSA-2
Cat.No: T8798
Synonym:
Target: STING
A-317491
Cat.No: TQ0002
Synonym: ABT 202
Target: P2X Receptor
BPTU
Cat.No: T4132
Synonym: BMS-646786
Target: P2Y Receptor
Tenofovir exalidex
Cat.No: T28946
Synonym: Tenofovir,HDP-Tenofovir,CMX-157,CMX157,CMX 157
Target: Antiviral
Deoxyguanosine triphosphate trisodium salt
Cat.No: T36688
Synonym: Deoxyguanosine 5-triphosphate,2'-Deoxyguanosine-5'-triphosphate trisodium salt,dGTP trisodium salt
Target: Nucleoside Antimetabolite/Analog
ERCC1-XPF-IN-2
Cat.No: T60904
Synonym:
Target: Others
VVD-214
Cat.No: T85309
Synonym:
Target: Others
GSK717
Cat.No: T38361
Synonym:
Target: IL Receptor, NOD
mSIRK
Cat.No: T80548
Synonym:
Target: ERK
PIT
Cat.No: T23164
Synonym: 2,2'-Pyridylisatogen tosylate
Target: P2Y Receptor
Nolatrexed dihydrochloride
Cat.No: T2627
Synonym: 盐酸诺拉曲塞,Thymitaq,AG 337
Target: DNA/RNA Synthesis
CID44216842
Cat.No: T8930
Synonym: KUC103479N-02
Target: CDK, Ras
Cat. No. Product Name Target Signaling Pathways
T22446 NADP disodium salt

Disodium NADP,Triphosphopyridine nucleotide disodium salt,beta-烟酰胺腺嘌呤二核苷酸磷酸二钠盐

Others Others
NADP disodium salt (Disodium NADP) 是一种氧化还原辅助因子,是一种烟酰胺腺嘌呤二核苷酸。它是代谢中电子转移的关键辅因子,可以被交替氧化 (NADP+) 和还原 (NADPH)。
T4721 β-Nicotinamide mononucleotide

NMN,β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸

Others; Endogenous Metabolite Metabolism; Others
β-nicotinamide mononucleotide 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物。β-nicotinamide mononucleotide的作用包括其在细胞生化功能、心脏保护、糖尿病、肥胖相关并发症和阿尔茨海默病中的作用。
T65172 Flavin adenine dinucleotide

FAD

Endogenous Metabolite Metabolism
Flavin adenine dinucleotide (FAD) 是一种氧化还原辅因子,是蛋白质的辅基,参与机体多种代谢反应。
T5067 Flavin adenine dinucleotide disodium salt

Flavin Adenine Dinucleotide Disodium,黄素腺嘌呤二核苷酸二钠,FAD sodium salt,FAD-Na2

Others; Endogenous Metabolite Metabolism; Others
Flavin adenine dinucleotide disodium salt (FAD sodium salt) 是一种辅酶,作用是促进细胞氧化还原反应中黄素酶的电子转移。
T19477 Nicotinic acid mononucleotide

Others Others
Nicotinic acid mononucleotide is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD+.
T4832 Cytosine

6-Aminopyrimidin-2(1H)-one,4-Amino-2-hydroxypyrimidine,Cytosinimine,胞嘧啶

Endogenous Metabolite Metabolism
Cytosine (6-Aminopyrimidin-2(1H)-one) 是 DNA 和 RNA 中发现的四个主要碱基之一。它修饰表现出与表观遗传多样性和衰老有关的昼夜节律振荡。
T4718 Uridine 5'-monophosphate

Uridylic acid,尿苷5-单磷酸,UMP,Uridine phosphate,Uridine 5'-phosphoric acid,5'-Uridylic acid

Others; Endogenous Metabolite Metabolism; Others
Uridine 5'-monophosphate (Uridylic acid) 是一种单磷酸盐形式的尿嘧啶核苷酸,能够由从头途径或体内核苷酸和核酸的降解产物获得,是哺乳动物乳中的主要核苷酸类似物。
T4685 INOSINIC ACID

Inosine 5′-monophosphate,IMP,5'-肌苷酸,I-5'-P

Endogenous Metabolite Metabolism
Inosinic acid (IMP) 是内源性代谢产物。
T14140 Agaric acid

落叶松蕈酸,Agaricinic Acid

Mitochondrial Metabolism; AChR Metabolism; Neuroscience
Agaric acid (Agaricinic Acid) 来一种自真菌部落的Polyporus officinalis 和Polyporus igniarius。它可促进积累的 Ca2+流出,跨膜电位的破坏和线粒体肿胀。它通过其与腺嘌呤核苷酸转位酶的相互作用诱导线粒体通透性转变。它用于调节脂类代谢。
T37635 2'-Deoxyadenosine-5'-triphosphate trisodium

dATP trisodium

DNA/RNA Synthesis; Endogenous Metabolite Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
2'-Deoxyadenosine-5'-triphosphate trisodium (dATP trisodium) 是一种核苷酸,是 DNA 聚合酶的底物,在细胞中用于 DNA 合成或复制。
T8393 Uridine triphosphate trisodium salt

UTP, Trisodium Salt,Uridine 5'-triphosphate trisodium salt,尿苷-5'-三磷酸三钠盐,Uridine triphosphate (trisodium salt)

Others Others
Uridine triphosphate trisodium salt (UTP, Trisodium Salt) 是一种核苷酸,在正常和疾病状态,均能够调节胰腺内分泌和外分泌、通道、增殖、转运体和细胞内信号传导的功能。
T3791 Atractyloside A

AChR Neuroscience
Atractyloside A 是存在于一些植物中的贝壳杉类二萜糖苷,具有降血压、降血糖、抗肿瘤等活性。
T5073 Inosine 5'-monophosphate disodium salt hydrate

Inosine 5'-monophosphate disodium salt,5'-IMP-Na2,肌苷5-单磷酸二钠盐水合物,Disodium 5'-inosinate monohydrate

Others; Endogenous Metabolite Metabolism; Others
Inosine 5'-monophosphate disodium salt hydrate (Inosine 5'-monophosphate disodium salt) 或肌苷酸是次黄嘌呤的核糖核苷酸,是嘌呤合成过程中形成的第一个核苷酸。
TMO2752 Cytidine 5'-monophosphate

5'-Cytidylic acid,5'-CMP,胞苷酸,Cytidylic Acid

Others; Endogenous Metabolite Metabolism; Others
Cytidine 5'-monophosphate (5'-Cytidylic acid) 是一种核苷酸,是组成 RNA 的基本单位之一。它由核碱基胞嘧啶,戊糖核糖和磷酸基团组成。
T4942 Galactose 1-phosphate Potassium salt

D-半乳糖 1-磷酸二钾盐五水合物,α-D-Galactose-1-phosphate Dipotassium Pentahydrate

Others; Endogenous Metabolite Metabolism; Others
Galactose 1-phosphate Potassium salt (α-D-Galactose-1-phosphate Dipotassium Pentahydrate) 是一种半乳糖代谢中的中间体和核苷酸糖。
T12295 Oleoylcarnitine

Oleoyl-L-carnitine

Endogenous Metabolite Metabolism
Oleoylcarnitine (Oleoyl-L-carnitine) 抑制腺嘌呤核苷酸转位酶 (AdNT) 活性,ic50为14 μM。Oleoylcarnitine 是检测神经分裂的重要指标。
T5270 5-Methylcytosine

Others; DNA/RNA Synthesis; Endogenous Metabolite Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
5-Methylcytosine 是一种存在于真核 DNA 中的甲基化核苷酸碱基。它是由 DNA 甲基转移酶作用形成的表观遗传修饰。
T19083 1-Methylinosine

N1-Methylinosine,Inosine, 1-methyl,1-甲基肌苷

Nucleoside Antimetabolite/Analog; Endogenous Metabolite Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
1-Methylinosine (N1-Methylinosine) 是在真核生物 tRNA 反密码子 3' 位 tRNA 的 37 位上发现的修饰核苷酸,具有代谢物的作用。
T4824 5,6-Dimethyl-1H-benzo[d]imidazole

5,6-Dimethylbenzimidazole,5,6-二甲基苯并咪唑

Others; Endogenous Metabolite Metabolism; Others
5,6-Dimethyl-1H-benzo[d]imidazole (5,6-Dimethylbenzimidazole) 是内源性代谢产物的一种。
TN1691 Glabrol

光甘草酚,光甘草醇

P450; NF-κB; NO Synthase; Acyltransferase Immunology/Inflammation; Metabolism; NF-κB
Glabrol 是分离自甘草根的乙醇提取物中的一种异戊二烯类黄酮,是一种有效且非竞争性的酰基辅酶 A:胆固醇酰基转移酶(ACAT)抑制剂,抑制大鼠肝脏微粒体 ACAT 的IC50为 24.6 μM。
T1083 Theophylline

Theo-24,1,3-Dimethylxanthine,茶碱

Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物,具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。
T8787 Drotaverine hydrochloride

PDE Metabolism
Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂,也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂,可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果,但无抗胆碱能的效果。
T4743 Uridine 5′-diphosphoglucose disodium salt

二磷酸尿苷葡萄糖二钠盐,UDP-Glucose sodium salt,UDPG sodium salt,UDP-α-D-Glucose sodium salt,Uridine 5'-diphosphoglucose disodium sal

Endogenous Metabolite; P2Y Receptor GPCR/G Protein; Metabolism; Neuroscience
Uridine 5′-diphosphoglucose disodium salt (UDP-Glucose sodium salt) 是一种内源性核苷酸糖,参与代谢中的糖基转移酶反应。它是 P2Y14 受体的激动剂,EC50为 0.35 μM。
T0853L Adenosine 5'-monophosphate monohydrate

5'-AMP,腺苷-5'-单磷酸一水合物,5'-AMP monohydrate,5'-Adenylic acid

AMPK; Adenosine Receptor; HSV Chromatin/Epigenetic; GPCR/G Protein; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
Adenosine 5'-monophosphate monohydrate (5'-AMP) 是一种核苷酸,用作 RNA 中的单体。它是一个腺苷 A1受体激动剂,对HSV-1和HSV-2具有显著的抗病毒活性。
T5079 Adenosine 5'-diphosphate sodium salt

腺苷-5‘-二磷酸钠盐,Adenosine-5'-diphosphate trisodium salt,ADP sodium salt

Others; Endogenous Metabolite Metabolism; Others
Adenosine 5'-diphosphate sodium salt (ADP sodium salt) 是一种核苷二磷酸,是一种 ATP 酶对 ATP 去磷酸化的产物。它通过在 P2T-嘌呤受体上的作用诱导人血小板聚集并抑制刺激的腺苷酸环化酶。
T1362 Hypoxanthine

次黄嘌呤,6-羟基嘌呤,6-Hydroxypurine,Purin-6-ol,Sarcine,Sarkin

Others; Endogenous Metabolite Metabolism; Others
Hypoxanthine (Purin-6-ol),也被称为 purine-6-ol 或 Hyp,是一种天然存在的嘌呤衍生物,是腺苷代谢和核苷酸补救途径形成核酸的反应中间体。在正常情况下,Hypoxanthine 很容易转化为尿酸。Hypoxanthine 首先被氧化为黄嘌呤,黄嘌呤再被黄嘌呤氧化酶氧化为尿酸。
T4839 Ac-Ala-OH

N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸

Others; Endogenous Metabolite Metabolism; Others
Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。
T4826 L-Histidine monohydrochloride monohydrat

Others; Endogenous Metabolite Metabolism; Others
L-Histidine monohydrochloride monohydrat 是一种 α-氨基酸。 L-异构体是 22 种蛋白质氨基酸之一,即蛋白质的组成部分。
T16397 Ophiobolin A

Others Others
Ophiobolin A is a fungal metabolite and a phytotoxin and is an effective and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase (IC50: 9 μM). Ophiobolin A also has antimicrobial and anticancer activity.
T38415 Adenosine 5′-monophosphoramidate sodium

Others Others
Adenosine 5′-monophosphoramidate sodium is a derivative of adenosine used as an intermediate for nucleotide synthesis. It significantly influences the accumulation of cyclic AMP.
T16837 SAICAR

Others Others
SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner (EC50: 0.3 mM).
T19334 Galactose 1-phosphate

Others Others
Galactose 1-phosphate, an intermediate substance in both galactose metabolism and nucleotide sugar processes, plays a crucial role in the biochemical pathways involved.
T75579 UDP-xylose disodium

Others Others
UDP-xylose disodium为从Cryptococcus laurentii (N RRL Y-1401)中提取的天然产物,属于核苷酸糖代谢过程中的一种代谢产物。
T83789 7-Deazaadenosine-5'-O-diphosphate sodium

7-CH-ADP,Tubercidin 5’-diphosphate,TuDP

Others Others
7-Deazaadenosine-5'-O-diphosphate是一种修饰过的核苷酸和tubercidin的代谢物。该化合物通过磷酸化tubercidin形成,并进一步磷酸化生成活性代谢物7-deazaadenosine-5'-O-triphosphate。
T75525 UDP-rhamnose

UDP-L-rhamnose

Endogenous Metabolite Metabolism
UDP-rhamnose (UDP-L-rhamnose) 是一种广泛存在于动植物中的糖核苷酸,可用于合成细胞壁中果胶。UDP-rhamnose 可被真菌中识别,可用于合成槲皮素。
T75676 Orotidine 5′-monophosphate trisodium

Others Others
Orotidine 5'-monophosphate trisodium 是一种嘧啶核苷酸。Orotidine 5'-monophosphate trisodium 是通过从头合成途径合成的,用于在大量微生物中合成 DNA,包括 M. tuberculosis、S. cerevisiae、S. typhimurium 和 P. falciparum 等等。乳清酸磷酸核糖基转移酶 (OPRT) 以磷酸核糖焦磷酸 (PRPP) 和乳清酸 (OA) 作为底物催化合成 Orotidine 5'-monophosphate trisodium[1]
T36667 2'-Deoxyadenosine-5'-triphosphate

dATP,Deoxyadenosine 5-triphosphate

DNA/RNA Synthesis; Endogenous Metabolite Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) 是一种天然存在的小分子核苷酸,在细胞中用于DNA合成或复制。2'-Deoxyadenosine-5'-triphosphate (dATP) 是 DNA 聚合酶的底物。2'-Deoxyadenosine-5'-triphosphate 通过无活性的 α4beta4 四级结构抑制RNA。2'-Deoxyadenosine-5'-triphosphate 与心肌细胞生长有关。

天然产物

NADP disodium salt
Cat.No: T22446
Synonym: Disodium NADP,Triphosphopyridine nucleotide disodium salt,beta-烟酰胺腺嘌呤二核苷酸磷酸二钠盐
Target: Others
β-Nicotinamide mononucleotide
Cat.No: T4721
Synonym: NMN,β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸
Target: Others, Endogenous Metabolite
Flavin adenine dinucleotide
Cat.No: T65172
Synonym: FAD
Target: Endogenous Metabolite
Flavin adenine dinucleotide disodium salt
Cat.No: T5067
Synonym: Flavin Adenine Dinucleotide Disodium,黄素腺嘌呤二核苷酸二钠,FAD sodium salt,FAD-Na2
Target: Others, Endogenous Metabolite
Nicotinic acid mononucleotide
Cat.No: T19477
Synonym:
Target: Others
Cytosine
Cat.No: T4832
Synonym: 6-Aminopyrimidin-2(1H)-one,4-Amino-2-hydroxypyrimidine,Cytosinimine,胞嘧啶
Target: Endogenous Metabolite
Uridine 5'-monophosphate
Cat.No: T4718
Synonym: Uridylic acid,尿苷5-单磷酸,UMP,Uridine phosphate,Uridine 5'-phosphoric acid,5'-Uridylic acid
Target: Others, Endogenous Metabolite
INOSINIC ACID
Cat.No: T4685
Synonym: Inosine 5′-monophosphate,IMP,5'-肌苷酸,I-5'-P
Target: Endogenous Metabolite
Agaric acid
Cat.No: T14140
Synonym: 落叶松蕈酸,Agaricinic Acid
Target: Mitochondrial Metabolism, AChR
2'-Deoxyadenosine-5'-triphosphate trisodium
Cat.No: T37635
Synonym: dATP trisodium
Target: DNA/RNA Synthesis, Endogenous Metabolite
Uridine triphosphate trisodium salt
Cat.No: T8393
Synonym: UTP, Trisodium Salt,Uridine 5'-triphosphate trisodium salt,尿苷-5'-三磷酸三钠盐,Uridine triphosphate (trisodium salt)
Target: Others
Atractyloside A
Cat.No: T3791
Synonym:
Target: AChR
Inosine 5'-monophosphate disodium salt hydrate
Cat.No: T5073
Synonym: Inosine 5'-monophosphate disodium salt,5'-IMP-Na2,肌苷5-单磷酸二钠盐水合物,Disodium 5'-inosinate monohydrate
Target: Others, Endogenous Metabolite
Cytidine 5'-monophosphate
Cat.No: TMO2752
Synonym: 5'-Cytidylic acid,5'-CMP,胞苷酸,Cytidylic Acid
Target: Others, Endogenous Metabolite
Galactose 1-phosphate Potassium salt
Cat.No: T4942
Synonym: D-半乳糖 1-磷酸二钾盐五水合物,α-D-Galactose-1-phosphate Dipotassium Pentahydrate
Target: Others, Endogenous Metabolite
Oleoylcarnitine
Cat.No: T12295
Synonym: Oleoyl-L-carnitine
Target: Endogenous Metabolite
5-Methylcytosine
Cat.No: T5270
Synonym:
Target: Others, DNA/RNA Synthesis, Endogenous Metabolite
1-Methylinosine
Cat.No: T19083
Synonym: N1-Methylinosine,Inosine, 1-methyl,1-甲基肌苷
Target: Nucleoside Antimetabolite/Analog, Endogenous Metabolite
5,6-Dimethyl-1H-benzo[d]imidazole
Cat.No: T4824
Synonym: 5,6-Dimethylbenzimidazole,5,6-二甲基苯并咪唑
Target: Others, Endogenous Metabolite
Glabrol
Cat.No: TN1691
Synonym: 光甘草酚,光甘草醇
Target: P450, NF-κB, NO Synthase, Acyltransferase
Theophylline
Cat.No: T1083
Synonym: Theo-24,1,3-Dimethylxanthine,茶碱
Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy
Drotaverine hydrochloride
Cat.No: T8787
Synonym:
Target: PDE
Uridine 5′-diphosphoglucose disodium salt
Cat.No: T4743
Synonym: 二磷酸尿苷葡萄糖二钠盐,UDP-Glucose sodium salt,UDPG sodium salt,UDP-α-D-Glucose sodium salt,Uridine 5'-diphosphoglucose disodium sal
Target: Endogenous Metabolite, P2Y Receptor
Adenosine 5'-monophosphate monohydrate
Cat.No: T0853L
Synonym: 5'-AMP,腺苷-5'-单磷酸一水合物,5'-AMP monohydrate,5'-Adenylic acid
Target: AMPK, Adenosine Receptor, HSV
Adenosine 5'-diphosphate sodium salt
Cat.No: T5079
Synonym: 腺苷-5‘-二磷酸钠盐,Adenosine-5'-diphosphate trisodium salt,ADP sodium salt
Target: Others, Endogenous Metabolite
Hypoxanthine
Cat.No: T1362
Synonym: 次黄嘌呤,6-羟基嘌呤,6-Hydroxypurine,Purin-6-ol,Sarcine,Sarkin
Target: Others, Endogenous Metabolite
Ac-Ala-OH
Cat.No: T4839
Synonym: N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸
Target: Others, Endogenous Metabolite
L-Histidine monohydrochloride monohydrat
Cat.No: T4826
Synonym:
Target: Others, Endogenous Metabolite
Ophiobolin A
Cat.No: T16397
Synonym:
Target: Others
Adenosine 5′-monophosphoramidate sodium
Cat.No: T38415
Synonym:
Target: Others
SAICAR
Cat.No: T16837
Synonym:
Target: Others
Galactose 1-phosphate
Cat.No: T19334
Synonym:
Target: Others
UDP-xylose disodium
Cat.No: T75579
Synonym:
Target: Others
7-Deazaadenosine-5'-O-diphosphate sodium
Cat.No: T83789
Synonym: 7-CH-ADP,Tubercidin 5’-diphosphate,TuDP
Target: Others
UDP-rhamnose
Cat.No: T75525
Synonym: UDP-L-rhamnose
Target: Endogenous Metabolite
Orotidine 5′-monophosphate trisodium
Cat.No: T75676
Synonym:
Target: Others
2'-Deoxyadenosine-5'-triphosphate
Cat.No: T36667
Synonym: dATP,Deoxyadenosine 5-triphosphate
Target: DNA/RNA Synthesis, Endogenous Metabolite
Cat. No. Product Name Species Expression System
TMPH-02696 GNAQ Protein, Mouse, Recombinant (His & Myc)

Guanine nucleotide-binding protein G(q) subunit alp...

Mouse E. coli
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).
TMPY-03406 NMNAT1 Protein, Human, Recombinant (His)

PNAT1,LCA9,nicotinamide nucleotide adenylyltransfer...

Human Baculovirus Insect Cells
NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver, and kidney. NMNAT appears to have the ability to protect against axonal degeneration following mechanical or toxic insults. The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT enz...
TMPY-02802 GNG13 Protein, Human, Recombinant (His)

G(gamma)13,h2-35,G(γ)13,guanine nucleotide binding ...

Human E. coli
GNG13 is a subunit of heterotrimeric G proteins which consist of alpha, beta, and gamma subunits. Heterotrimeric G proteins are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. Each G protein is composed of an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding...
TMPJ-00473 QPRTase Protein, Human, Recombinant (His)

QPRTase,QAPRTase,Nicotinate-Nucleotide Pyrophosphor...

Human E. coli
Nicotinate-Nucleotide Pyrophosphorylase (QPRT) belongs to the nadC/modD family. QPRT plays an improtant role in catabolism of quinolinate which acts as a potent endogenous exitotoxin to neurons. In addition, QPRT serves as an an intermediate in the Tryptophan-Nicotinamide Adenine Dinucleotide pathway. QPRT participates in some pathways including Cofactor biosynthesis, NAD(+) biosynthesis and the Nicotinate D-Ribonucleotide from Quinolinate. In addition, QPRT is involved in the catabolism of Quin...
TMPY-02805 GNGT1 Protein, Human, Recombinant (His)

guanine nucleotide binding protein (G protein), γ t...

Human E. coli
GNGT1 is a subunit of transducin. Heterotrimeric G proteins consist of alpha, beta, and gamma subunits. They are membrane-bound GTPases that are linked to 7-TM receptors. They function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. They are involved as a modulator or transducer in various transmembrane signaling systems. G proteins are bound to GDP in the 'off' state. GNGT1 is the gamma subunit of transducin. Ligand-receptor binding results in detachment of the ...
TMPH-02697 GNA12 Protein, Mouse, Recombinant (His & Myc)

Guanine nucleotide-binding protein subunit alpha-12...

Mouse E. coli
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins. Promotes tumor cell invasion and metastasis by ac...
TMPH-02694 GNG12 Protein, Mouse, Recombinant (His & Myc)

Gng12,Guanine nucleotide-binding protein G(I)/G(S)/...

Mouse E. coli
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
TMPH-02695 GNAO1 Protein, Mouse, Recombinant (His)

Gnao1,Guanine nucleotide-binding protein G(o) subun...

Mouse E. coli
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Stimulated by RGS14. The G(o) protein function is not clear.
TMPH-01915 PREB Protein, Human, Recombinant (His & Myc)

Mammalian guanine nucleotide exchange factor mSec12...

Human E. coli
PREB Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-01421 GNAI3 Protein, Human, Recombinant (His)

GNAI3,G(i) alpha-3,Guanine nucleotide-binding prote...

Human E. coli
GNAI3 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.5 kDa and the accession number is P08754.
TMPH-00270 GNAT2 Protein, Bovine, Recombinant (His)

GNAT2,Transducin alpha-2 chain,Guanine nucleotide-b...

Bovine E. coli
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase. GNAT2 Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.0 kDa and the accession number is P04696.
TMPH-02041 ARHGEF12 Protein, Human, Recombinant (His)

ARHGEF12,KIAA0382,Rho guanine nucleotide exchange f...

Human E. coli
ARHGEF12 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-03254 PDE1C Protein, Rat, Recombinant (His)

Dual specificity calcium/calmodulin-dependent 3',5'-cyclic <...

Rat E. coli
PDE1C Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 92.6 kDa and the accession number is Q63421.
TMPH-01423 GNAZ Protein, Human, Recombinant (His & SUMO)

GNAZ,Gz-alpha,G(x) alpha chain,Guanine nucleotide-b...

Human E. coli
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. GNAZ Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.8 kDa and the accession number is P19086.
TMPH-03205 HINT1 Protein, Rabbit, Recombinant (His & Myc)

HINT1,Histidine triad nucleotide-binding protein 1,...

Rabbit HEK293 Cells
HINT1 Protein, Rabbit, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 17.6 kDa and the accession number is P80912.
TMPH-02693 GNAI2 Protein, Mouse, Recombinant (His)

Guanine nucleotide-binding protein G(i) subunit alp...

Mouse E. coli
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division.
TMPH-00289 NOD2 Protein, Bovine, Recombinant (His & KSI)

Caspase recruitment domain-containing protein 15,Nucleot...

Bovine E. coli
NOD2 Protein, Bovine, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 36.8 kDa and the accession number is Q6E804.
TMPH-01422 GNAS Protein, Human, Recombinant (His & SUMO)

Guanine nucleotide-binding protein G(s) subunit alp...

Human E. coli
Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. GNAS Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6...
TMPH-03209 CLNS1A Protein, Rabbit, Recombinant (His & Myc)

I(Cln),Chloride conductance regulatory protein ICln,Methylos...

Rabbit E. coli
CLNS1A Protein, Rabbit, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 33.4 kDa and the accession number is Q28678.
TMPH-01553 GBP2 Protein, Human, Recombinant (E. coli, His)

Interferon-induced guanylate-binding protein 2,GBP2,Guanylat...

Human E. coli
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP. Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. GBP2 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.4 kDa and the accession number is P32456.
TMPH-00906 SLC25A6 Protein, Human, Recombinant (His & KSI)

ADP,ATP carrier protein 3,SLC25A6,ADP,ATP carrier protein, i...

Human E. coli
SLC25A6 Protein, Human, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 20.2 kDa and the accession number is P12236.
TMPH-01738 NLRP1 Protein, Human, Recombinant (GST)

Caspase recruitment domain-containing protein 7,Nucleoti...

Human E. coli
NLRP1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 42.9 kDa and the accession number is Q9C000.
TMPY-04310 Apolipoprotein A-IV/APOA4 Protein, Human, Recombinant (His)

apolipoprotein A-IV

Human HEK293 Cells
Apolipoprotein is genetically associated with the risk of Alzheimer's disease (AD). The APOA1, APOC3, and APOA4 genes are closely linked and located on human chromosome 11. There was a decreased trend for levels of APOA1, APOC3, and APOA4 in AD patients. CONCLUSION: Low levels of APOA1, APOC3, and APOA4 are associated with risk of AD. APOA1, APOC3, and APOA4 should be developed as combined drugs for the therapy of AD. SNP(single nucleotide polymorphisms)in APOA1and APOA4 genes influences atherog...
TMPY-03855 DNase I Protein, Human, Recombinant (His)

DRNI,DNL1,deoxyribonuclease I

Human HEK293 Cells
DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations i...
TMPY-02575 PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)

CIMT1,PPARγ,GLM1,PPARgamma,PPARG1,PPARG2,NR1C3,peroxisome pr...

Human Baculovirus Insect Cells
Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proli...
TMPH-01024 Calbindin Protein, Human, Recombinant (His)

Vitamin D-dependent calcium-binding protein, avian-type,D-28...

Human P. pastoris (Yeast)
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Calbindin Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P05937.
TMPY-01819 PDE1B Protein, Human, Recombinant (His & GST)

PDES1B,phosphodiesterase 1B, calmodulin-dependent,PDE1B1

Human Baculovirus Insect Cells
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Phosphodiesterase-1A (PDE1A), Phosphodiesterase-1B (PDE1B), Phosphodiesterase-4B (PDE4B), and Phosphodiesterase-4A (PDE4A) are important regulators of signal transduction in striatum due to their catalysis of cyclic AMP and cyclic GMP. PDE1B is highly expressed in the striatum. It b...
TMPY-02880 ENPP5 Protein, Human, Recombinant (His)

NPP-5,ectonucleotide pyrophosphatase/phosphodiester...

Human HEK293 Cells
ENPP5 is a member of the nucleotide pyrophosphatase/phosphodiesterase family (NPP). It is a family comprised of dimeric enzymes that catalyze the hydrolysis of phosphate diester bonds. There are seven isoforms in NPP family, some of which prefer nucleotide substrates, some of which prefer phospholipid substrates, and others of which prefer substrates that have not yet been determined. NPP also belongs to the alkaline phosphatase (AP) superfamily of enzymes and they are located in the cell membra...
TMPY-03849 NUDT5 Protein, Human, Recombinant (His)

hYSAH1,YSAH1,nudix (nucleoside diphosphate linked moiety X)-...

Human E. coli
NUDT5 (Nudix Hydrolase 5) is a Protein Coding gene. This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates. ADP-sugar Pyrophosphatase, also known as NUDT5, eliminates toxic nucleotide derivatives from the cell and regulates the levels of important signaling nucleotides and their metabolites. It is widely expressed in the liver, skin, and other tissues. NUDT5 functions as a MutT...
TMPJ-01072 GALK2 Protein, Human, Recombinant (His)

GalNAc kinase,N-acetylgalactosamine kinase,Galactokinase 2,G...

Human HEK293 Cells
GALK2 acts as a galactokinase when galactose is present at high concentrations. GALK2 may be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. GALK2 has been reported to participate in pathways , such as Amino sugar and nucleotide sugar metabolism, Galactose metabolism and Metabolic pathways.
TMPJ-00792 DNA PolymeraseBeta Protein, Human, Recombinant (His)

DNA Polymeraseβ,POLB,DNA Polymerase Beta,DNA Polymerase β

Human E. coli
Human DNA polymerase β is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. It conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a proce...
TMPH-03503 Adenylate kinase Protein, Shigella flexneri, Recombinant (His & Myc & SUMO)

ATP-AMP transphosphorylase,AK,Adenylate monophosphate kinase...

Shigella flexneri E. coli
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase Protein, Shigella flexneri, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 43.6 kDa and the accession number is Q83M40.
TMPH-02829 Phospholipase D3/PLD3 Protein, Mouse, Recombinant (His)

Phosphatidylcholine-hydrolyzing phospholipase D3,Pld3,Cholin...

Mouse E. coli
5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting.
TMPH-02313 RPGR Protein, Human, Recombinant (hFc)

RPGR,X-linked retinitis pigmentosa GTPase regulator

Human HEK293 Cells
Could be a guanine-nucleotide releasing factor. Plays a role in ciliogenesis. Probably regulates cilia formation by regulating actin stress filaments and cell contractility. Plays an important role in photoreceptor integrity. May play a critical role in spermatogenesis and in intraflagellar transport processes. May be involved in microtubule organization and regulation of transport in primary cilia.
TMPH-02300 RAD23A Protein, Human, Recombinant (His)

UV excision repair protein RAD23 homolog A,RAD23A

Human E. coli
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucle...
TMPK-01268 Complement C2 Protein, Cynomolgus, Recombinant (His)

C2,CO2,Complement C2,C3/C5 convertase,ARMD14

Cynomolgus HEK293 Cells
Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to healthy controls, and C2 was associated with TNM stages. Higher C2 expression was significantly associated with better prognosis, and multivariate analysis showed that C2 was also an independent factor for the prognosis of HCC.
TMPY-05055 GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His)

GGH/Glutamyl hydrolase γ,γ-glutamyl hydrolase (conjugase, fo...

Human HEK293 Cells
gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer.
TMPH-02964 UMP-CMP kinase/CMPK1 Protein, Mouse, Recombinant (His & SUMO)

Cmpk1,UMP-CMP kinase,Nucleoside-diphosphate kinase,Uridine m...

Mouse E. coli
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. UMP-CMP kinase/CMPK1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 38.2 kDa and the accession number is Q9DBP5.
TMPH-02649 FAN1 Protein, Mouse, Recombinant (His & Myc)

Fanconi-associated nuclease 1,Myotubularin-related protein 1...

Mouse E. coli
Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to e...
TMPY-02977 PDE1C Protein, Human, Recombinant (His & GST)

hCam-3,phosphodiesterase 1C, calmodulin-dependent 70kDa,cam-...

Human Baculovirus Insect Cells
PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s...
TMPJ-00689 EIF1B Protein, Human, Recombinant (His)

Protein Translation Factor SUI1 Homolog GC20,EIF1B,Eukaryoti...

Human E. coli
Eukaryotic Translation Initiation Factor 1B (EIF1B) is an element of a complex involved in recognition of the initiator codon during the scanning process. Translation is also initiated by the function of EIF1B in regulating the activity of ribosomal subunits 43S, 48S and 40S. EIF1B enables 43S ribosomal complexes to distinguish between cognate and near-cognate initiation codons, perceiving the nucleotide content of initiation codons.
TMPH-01663 GRM5 Protein, Human, Recombinant (His & Myc)

Metabotropic glutamate receptor 5,GRM5

Human E. coli
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
TMPH-00039 Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc)

Single-strand DNA-binding protein,63.5 kDa virulence protein...

Agrobacterium fabrum E. coli
Involved in DNA transformation; mediates the nuclear uptake of single-stranded DNA copies of the transferred DNA (T-DNA) element. Binds single-stranded but not double-stranded DNA regardless of nucleotide sequence composition. Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 70.3 kDa and the accession number is P08062.
TMPK-00839 ITGB6 Protein, Human, Recombinant (His)

β6,Integrin β-6,β 6,beta 6,Integrin β 6,Integrin beta-6,Inte...

Human HEK293 Cells
ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide polymorphism (SNP), G29A, db SNP Id: rs109075046, in the 5' untranslated region (5'UTR) of the bovine ITGB6 gene. ITGB6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 75.4 kDa and the accession number is ...
TMPK-01031 MAdCAM-1 Protein, Mouse, Recombinant (His)

MACAM1,MADCAM1,MAdCAM-1

Mouse HEK293 Cells
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The pred...
TMPK-01247 ITGB6 Protein, Mouse, Recombinant (His)

ITGB6,Integrin β-6,Integrin beta-6

Mouse HEK293 Cells
ITGB6 is known to be one of the major receptor components involved in host tropism of foot-and-mouth disease (FMD) virus in cattle. A competitive PCR technique called ARMS PCR was adapted to identify a single-nucleotide polymorphism (SNP), G29A, db SNP Id: rs109075046, in the 5' untranslated region (5'UTR) of the bovine ITGB6 gene. ITGB6 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 75.7 kDa and the accession number is ...
TMPY-02081 PDE2A Protein, Human, Recombinant (aa 215-900, His)

phosphodiesterase 2A, cGMP-stimulated,cGSPDE,PED2A4,PDE2A1,C...

Human Baculovirus Insect Cells
cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac ...
TMPY-04480 UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)

CMPK,UMPK,UMK,CK,UMP-CMPK,CMK,cytidine monophosphate (UMP-CM...

Human Baculovirus Insect Cells
CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid bi...
TMPY-03617 GMPR Protein, Human, Recombinant (His)

GMPR1,guanosine monophosphate reductase

Human E. coli
GMPR, also known as GMPR1, belongs to the IMPDH/GMPR family.This familyofenzymesincludesIMP dehydrogenaseandGMP reductase. These enzymes are involved inpurine metabolism and adopt aTIM barrelstructure. GMPR is an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP. GMPR functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
TMPK-00965 MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc)

MADCAM1,MACAM1,MAdCAM-1

Human HEK293 Cells
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc) is expressed in HEK293 mammalian cells with C-hFc ta...
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重组蛋白

GNAQ Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02696
Species: Mouse
Expression System: E. coli
NMNAT1 Protein, Human, Recombinant (His)
Cat.No: TMPY-03406
Species: Human
Expression System: Baculovirus Insect Cells
GNG13 Protein, Human, Recombinant (His)
Cat.No: TMPY-02802
Species: Human
Expression System: E. coli
QPRTase Protein, Human, Recombinant (His)
Cat.No: TMPJ-00473
Species: Human
Expression System: E. coli
GNGT1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02805
Species: Human
Expression System: E. coli
GNA12 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02697
Species: Mouse
Expression System: E. coli
GNG12 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02694
Species: Mouse
Expression System: E. coli
GNAO1 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02695
Species: Mouse
Expression System: E. coli
PREB Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01915
Species: Human
Expression System: E. coli
GNAI3 Protein, Human, Recombinant (His)
Cat.No: TMPH-01421
Species: Human
Expression System: E. coli
GNAT2 Protein, Bovine, Recombinant (His)
Cat.No: TMPH-00270
Species: Bovine
Expression System: E. coli
ARHGEF12 Protein, Human, Recombinant (His)
Cat.No: TMPH-02041
Species: Human
Expression System: E. coli
PDE1C Protein, Rat, Recombinant (His)
Cat.No: TMPH-03254
Species: Rat
Expression System: E. coli
GNAZ Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01423
Species: Human
Expression System: E. coli
HINT1 Protein, Rabbit, Recombinant (His & Myc)
Cat.No: TMPH-03205
Species: Rabbit
Expression System: HEK293 Cells
GNAI2 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02693
Species: Mouse
Expression System: E. coli
NOD2 Protein, Bovine, Recombinant (His & KSI)
Cat.No: TMPH-00289
Species: Bovine
Expression System: E. coli
GNAS Protein, Human, Recombinant (His & SUMO)
Cat.No: TMPH-01422
Species: Human
Expression System: E. coli
CLNS1A Protein, Rabbit, Recombinant (His & Myc)
Cat.No: TMPH-03209
Species: Rabbit
Expression System: E. coli
GBP2 Protein, Human, Recombinant (E. coli, His)
Cat.No: TMPH-01553
Species: Human
Expression System: E. coli
SLC25A6 Protein, Human, Recombinant (His & KSI)
Cat.No: TMPH-00906
Species: Human
Expression System: E. coli
NLRP1 Protein, Human, Recombinant (GST)
Cat.No: TMPH-01738
Species: Human
Expression System: E. coli
Apolipoprotein A-IV/APOA4 Protein, Human, Recombinant (His)
Cat.No: TMPY-04310
Species: Human
Expression System: HEK293 Cells
DNase I Protein, Human, Recombinant (His)
Cat.No: TMPY-03855
Species: Human
Expression System: HEK293 Cells
PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-02575
Species: Human
Expression System: Baculovirus Insect Cells
Calbindin Protein, Human, Recombinant (His)
Cat.No: TMPH-01024
Species: Human
Expression System: P. pastoris (Yeast)
PDE1B Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-01819
Species: Human
Expression System: Baculovirus Insect Cells
ENPP5 Protein, Human, Recombinant (His)
Cat.No: TMPY-02880
Species: Human
Expression System: HEK293 Cells
NUDT5 Protein, Human, Recombinant (His)
Cat.No: TMPY-03849
Species: Human
Expression System: E. coli
GALK2 Protein, Human, Recombinant (His)
Cat.No: TMPJ-01072
Species: Human
Expression System: HEK293 Cells
DNA PolymeraseBeta Protein, Human, Recombinant (His)
Cat.No: TMPJ-00792
Species: Human
Expression System: E. coli
Adenylate kinase Protein, Shigella flexneri, Recombinant (His & Myc & SUMO)
Cat.No: TMPH-03503
Species: Shigella flexneri
Expression System: E. coli
Phospholipase D3/PLD3 Protein, Mouse, Recombinant (His)
Cat.No: TMPH-02829
Species: Mouse
Expression System: E. coli
RPGR Protein, Human, Recombinant (hFc)
Cat.No: TMPH-02313
Species: Human
Expression System: HEK293 Cells
RAD23A Protein, Human, Recombinant (His)
Cat.No: TMPH-02300
Species: Human
Expression System: E. coli
Complement C2 Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-01268
Species: Cynomolgus
Expression System: HEK293 Cells
GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His)
Cat.No: TMPY-05055
Species: Human
Expression System: HEK293 Cells
UMP-CMP kinase/CMPK1 Protein, Mouse, Recombinant (His & SUMO)
Cat.No: TMPH-02964
Species: Mouse
Expression System: E. coli
FAN1 Protein, Mouse, Recombinant (His & Myc)
Cat.No: TMPH-02649
Species: Mouse
Expression System: E. coli
PDE1C Protein, Human, Recombinant (His & GST)
Cat.No: TMPY-02977
Species: Human
Expression System: Baculovirus Insect Cells
EIF1B Protein, Human, Recombinant (His)
Cat.No: TMPJ-00689
Species: Human
Expression System: E. coli
GRM5 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-01663
Species: Human
Expression System: E. coli
Single-strand DNA-binding protein Protein, Agrobacterium fabrum, Recombinant (His & Myc)
Cat.No: TMPH-00039
Species: Agrobacterium fabrum
Expression System: E. coli
ITGB6 Protein, Human, Recombinant (His)
Cat.No: TMPK-00839
Species: Human
Expression System: HEK293 Cells
MAdCAM-1 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-01031
Species: Mouse
Expression System: HEK293 Cells
ITGB6 Protein, Mouse, Recombinant (His)
Cat.No: TMPK-01247
Species: Mouse
Expression System: HEK293 Cells
PDE2A Protein, Human, Recombinant (aa 215-900, His)
Cat.No: TMPY-02081
Species: Human
Expression System: Baculovirus Insect Cells
UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)
Cat.No: TMPY-04480
Species: Human
Expression System: Baculovirus Insect Cells
GMPR Protein, Human, Recombinant (His)
Cat.No: TMPY-03617
Species: Human
Expression System: E. coli
MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc)
Cat.No: TMPK-00965
Species: Human
Expression System: HEK293 Cells
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Cat. No. Product Name Target Signaling Pathways
TMID-0167 6-Hydroxypurine-d4

6-Hydroxypurine-d4 是 6-Hydroxypurine 的氘代化合物。6-Hydroxypurine 的 CAS 号为 68-94-0。Hypoxanthine,也被称为 purine-6-ol 或 Hyp,属于嘌呤类有机化合物。Hypoxanthine 是一种天然存在的嘌呤衍生物,是腺苷代谢和核苷酸补救途径形成核酸的反应中间体。在正常情况下,Hypoxanthine 很容易转化为尿酸。Hypoxanthine 首先被氧化为黄嘌呤,黄嘌呤再被黄嘌呤氧化酶氧化为尿酸。

同位素标记化合物

6-Hydroxypurine-d4
Cat.No: TMID-0167
Synonym:
Target:
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