首页工具

登录

搜索结果

Search Results for " cyclin dependent kinase "

Targets Recommended: CDK

199

抑制剂 & 化合物

12

天然产物

23

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T60025	Eciruciclib	CDK	Cell Cycle/Checkpoint
	Eciruciclib 是一种具有抗肿瘤特性的 CDK 抑制剂。
T5673	Senexin A	CDK	Cell Cycle/Checkpoint
	Senexin A 是一种有效且选择性的 CDK8 抑制剂，它还抑制 CDK19，Kd 值分别为0.83μM 和0.31μM。
T7789	DRB	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	DRB 是一种核苷类似物，对几种羧基末端结构域激酶（包括酪蛋白激酶 II 、细胞周期依赖性激酶）有抑制作用。它可诱导人类结肠腺癌细胞的 p53 依赖性凋亡，且不会诱发健康细胞遗传毒性应激。
T5358	Longdaysin	ERK; Casein Kinase; CDK	Cell Cycle/Checkpoint; MAPK; Metabolism; Stem Cells
	Longdaysin 是一种 CK1α 和 CK1δ 的抑制剂，IC50为5.6和8.8 µM。它还抑制ERK2，IC50值为52 µM。它是Wnt/β-catenin 信号通路的抑制剂，通过阻断CK1δ/ε依赖性 Wnt 信号通路发挥抗肿瘤作用。
T7426	ALSTERPAULLONE	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	Alsterpaullone 是高效的 CDK 抑制剂，是一种 ATP 竞争性的 GSK-3alpha/GSK-3beta 抑制剂，且作用的 IC50值都为 4 nM。它有用于神经退行性和增生性疾病的研究潜力，具有抗肿瘤活性，诱导白血病细胞凋亡。
T6312	R547 Ro 4584820	Apoptosis; GSK-3; PKA; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells; Tyrosine Kinase/Adaptors
	R547 (Ro 4584820) 是一种口服有效，选择性， ATP 竞争性CDK 抑制剂，对 CDK1/cyclin B、 CDK2/cyclin E 和 CDK4/cyclin D1 作用的Ki 值分别为 2 nM、3 nM、1 nM。
T2029	Bohemine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Bohemine 是一种合成的选择性CDK 抑制剂，是嘌呤类似物，具有抗癌活性。它对Cdk2/cyclin E、Cdk2/cyclin A 和Cdk9/cyclin T1的IC50分别为 4.6 μM、83 μM 和 2.7 μM。
T16359	NU6140	CDK; Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	NU6140 是选择性CDK2-cyclin A 抑制剂，IC50为0.41 μM。它显示出比其他 CDK 高 10 到 36 倍的选择性。它还抑制Aurora A 和Aurora B 的活性，IC50值分别为 67 和 35 nM。它还增强细胞凋亡作用并具有抗癌活性。
T5395	BSJ-03-123	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	BSJ-03-123是一种有效的 CDK6 选择性小分子降解剂，是由 Cereblon 配体和 CDK 配体相连的 PROTAC。
T2356	Ro-3306	Apoptosis; ERK; SGK; PKA; CDK; PKC	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; Tyrosine Kinase/Adaptors
	Ro 3306 是一种 CDK1 抑制剂，可以抑制 CDK1、CDK1/cyclin B1 和 CDK2/cyclin E (Ki=20/35/340 nM)，具有选择性和 ATP 竞争性。Ro-3306 具有抗肿瘤活性，可以抑制细胞周期阻滞，诱导细胞凋亡。
T39957	CDK4/6-IN-6	CDK	Cell Cycle/Checkpoint
	CDK4/6-IN-6 是CDK4/CDK6的有效抑制剂，结合CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 为 0.6 nM 和 13.9 nM。
TQ0266	MSC2530818	CDK	Cell Cycle/Checkpoint
	MSC2530818 是一种有效的、选择性的、可口服的 CDK8 抑制剂，IC50值为2.6 nM。
T8801	SRI-29329	CDK	Cell Cycle/Checkpoint
	SRI-29329 是一种有效的、特异性的 CDC 样激酶抑制剂，对 CLK1、CLK2 和 CLK4 的 IC50 分别为 78 nM、16 nM 和 86 nM。
T10436	AZD4573	CDK	Cell Cycle/Checkpoint
	AZD4573 是一种有效的选择性 CDK9 抑制剂，IC50值小于 4 nM，可以用于治疗血液系统恶性肿瘤的研究。
T4482	CC-671	Others; CDK	Cell Cycle/Checkpoint; Others
	CC-671 是一种双重 TTK 蛋白激酶/CLK2抑制剂, 对于 TTK 和 CLK2 的IC50值分别为 0.005 和 0.006 μM。
T16391	ON-013100	CDK	Cell Cycle/Checkpoint
	ON-013100 是有丝分裂的抑制剂，具有抗肿瘤活性。ON-013100能够抑制细胞周期蛋白 D1 的表达。
T14901	CCT-251921	CDK	Cell Cycle/Checkpoint
	CCT-251921是一种有口服活性的选择性CDK8抑制剂；IC50值为2.3 nM。
T6126	JNJ-7706621 JNJ 7706621	Apoptosis; CDK; Aurora Kinase	Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic
	JNJ-7706621 是一种aurora kinase 抑制剂，有效抑制CDK1和CDK2，对CDK1，CDK2，aurora-A 和aurora-B 的IC50值分别为 9 nM，3 nM，11 nM 和 15 nM。
TQ0060	LY2857785	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	LY2857785 是 I 型可逆的 ATP 竞争性 CDK9、CDK8和 CDK7抑制剂，IC50分别为 11 nM、16 nM 和 246 nM。
T3352	XL413	cholecystokinin; Casein Kinase; Pim; CDK	Cell Cycle/Checkpoint; Chromatin/Epigenetic; GPCR/G Protein; JAK/STAT signaling; Metabolism; Stem Cells
	XL413 是一种口服生物可利用的细胞分裂周期 7 同源物 (CDC7) 激酶抑制剂，具有潜在的抗肿瘤活性，IC50值为 3.4 nM。它对 pMCM 的 EC50值为 118 nM，对 CK2 和 PIM1 的 IC50值分别为 215 和 42 nM。
T4293	THZ531	CDK	Cell Cycle/Checkpoint
	THZ531 是一种选择性CDK12和CDK13共价抑制剂，IC50值分别为 158 nM 和 69 nM。
T8484	JSH-150	CDK	Cell Cycle/Checkpoint
	JSH-150 是一种高选择性的 CDK9抑制剂， IC50为 1 nM。
T14916	CDK2-IN-4	CDK	Cell Cycle/Checkpoint
	CDK2-IN-4 是选择性的CDK2抑制剂，对 CDK2/cyclin A 的IC50值为 44 nM，选择性高出 CDK1/cyclin B 的 2,000 倍 (IC50=86 μM)。
T8378	AS2863619	CDK; STAT	Cell Cycle/Checkpoint; JAK/STAT signaling; Stem Cells
	AS2863619 是一种口服的细胞周期蛋白依赖性激酶 8 和CDK19抑制剂，抑制CDK8/19可增强STAT5的激活，从而激活 Foxp3 基因。它可将抗原特异性效应子/记忆 T 细胞转换为 Foxp3+调节性 T 细胞，以研究各种免疫疾病。
T8325	SR-4835	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	SR-4835 是一种 ATP 竞争性的 CDK12/CDK13高选择性抑制剂。它与破坏 DNA 的化学疗法和 PARP 抑制剂协同作用，并引起三阴性乳腺癌细胞凋亡。
T16021	MBQ-167	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	MBQ-167 是一种 Rac/Cdc42 的双重抑制剂，在 MDA-MB-231 细胞中，Rac 1/2/3 和 Cdc42 的 IC50 分别为 103 nM 和 78 nM。
T2506	AZD-5438 AZD5438	CDK	Cell Cycle/Checkpoint
	AZD-5438 有效抑制 CDK1,CDK2,CDK9，IC50值分别为 16 nM, 6 nM, 20 nM，但它对 GSK3β，CDK5，CDK6 的抑制作用较弱。
T6167	SU9516	Apoptosis; p38 MAPK; CDK; PKC; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK
	SU9516 是一种 CDK2抑制剂，IC50值为 22 nM，对 CDK1 和 CDK4 也有抑制作用，IC50值分别为 40 和 200 nM。
T13202	Trilaciclib hydrochloride G1T28 hydrochloride	CDK	Cell Cycle/Checkpoint
	Trilaciclib hydrochloride (G1T28 hydrochloride) 是一种CDK4/6的抑制剂，对 CDK4 和 CDK6 的IC50值分别为 1 nM 和 4 nM。
T6924	Riviciclib hydrochloride P276-00	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	Riviciclib hydrochloride (P276-00) 是一种CDK 抑制剂，抑制CDK9-cyclinT1、CDK4-cyclin D1、CDK1-cyclinB 的IC50值分别为 20 nM、63 nM、79 nM。它对 Cisplatin 耐药性细胞具有抗肿瘤活性。
T7810	LY3177833 LY-3177833	CDK	Cell Cycle/Checkpoint
	LY3177833 抑制CDC7和pMCM2，IC50值分别为 3.3 nM 和 290 nM。
T21966	MeBIO	GSK-3; Aryl Hydrocarbon Receptor; CDK	Cell Cycle/Checkpoint; Immunology/Inflammation; PI3K/Akt/mTOR signaling; Stem Cells
	MeBIO 是一种芳烃受体激动剂，对 GSK-3 和 CDK1/CyclinB 的 IC50 分别为 44 和 55 μM。 MeBIO 不影响 GSK-3β。
T11929	M2N12	Phosphatase	Metabolism
	M2N12 是一种高度选择性的细胞分裂周期蛋白磷酸酶 25C 抑制剂，IC50值为 0.09 μM。它还抑制 Cdc25A 和 Cdc25B 的活性，IC50值分别为 0.53 μM 和 1.39 μM。它具有抗肿瘤活性，可研究癌症。
T6205	AT7519	Apoptosis; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
	AT7519 是一种CDK 抑制剂，对 CDK1，CDK2，CDK4-CDK6 以及 CDK9 的IC50值分别为 210，47，100，13，170 和 <10 nM。
T17069	THAL-SNS-032	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	THAL-SNS-032 是一种选择性 CDK 降解剂，由 CereblonE3 连接酶 (CRBN) 的配体 thalidomide 衍生物、CDK 配体 SNS-032和 linker 组成的 PROTAC 连接体。
T9849	HQ461	CDK; Molecular Glues	Cell Cycle/Checkpoint; PROTAC
	HQ461 是一种分子胶，可促进 CDK12-DDB1 相互作用并触发cyclin K降解， cyclin K 的降解会损害 CDK12 的功能，导致 CDK12 底物磷酸化降低、DNA 损伤反应基因下调和细胞死亡。
T16363	NVP-2	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	NVP-2 是一种具有选择性的 ATP 竞争性细胞周期蛋白依赖性激酶 9 探针，可抑制 CDK9/CycT 活性，IC50值为 0.514 nM。它对 CDK1/CycB，CDK2/CycA 和 CDK16/CycY 激酶具有抑制作用，可诱导细胞凋亡。
T2113	PHA-793887 PHA 793887,PHA793887	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	PHA-793887 是一种ATP 竞争性的CDK 抑制剂，可抑制 Cdk2、Cdk1、Cdk4 和 Cdk9 的活性，IC50值分别为 8 nM、60 nM、62 nM 和 138 nM，同时可抑制糖原合酶激酶 3β，IC50值为 79 nM。
TQ0053	Fadraciclib CYC065	CDK	Cell Cycle/Checkpoint
	Fadraciclib (CYC065) 是一种口服有效的 ATP 竞争性的CDK2/CDK9激酶抑制剂，IC50分别为 5 和 26 nM。
T13467	(±)-Enitociclib (±)-BAY-1251152	CDK	Cell Cycle/Checkpoint
	(±)-Enitociclib ((±)-BAY-1251152) 是 BAY-1251152 的外消旋混合物。BAY-1251152 是一种高度选择性的 PTEF/CDK9抑制剂。
T11345L	Lerociclib dihydrochloride G1T38 dihydrochloride	CDK	Cell Cycle/Checkpoint
	Lerociclib dihydrochloride (G1T38 dihydrochloride) 是一种有效的选择性CDK4/CDK6抑制剂，抑制CDK6/CyclinD3和CDK4/CyclinD1，IC50值分别为 2 nM 和 1 nM。
T9117	BSJ-4-116	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	BSJ-4-116 是一种高效的选择性 CDK12 降解剂，IC50 为 6 nM，是由 Cereblon 配体和 CDK 配体相连的 PROTAC。它通过提前终止转录来下调 DDR 基因，主要是通过增加聚腺苷酸化，具有抗增殖作用。
T10744L	SEL120-34A HCl	CDK	Cell Cycle/Checkpoint
	SEL120-34A HCl 是一种可口服的，选择性的，ATP-竞争性的CDK8抑制剂，具有抗肿瘤活性，对 CDK8/CycC 和 CDK19/CycC 的IC50值分别为 4.4 nM 和 10.4 nM。
T21678	3MB-PP1	PLK	Cell Cycle/Checkpoint
	3MB-PP1是嘌呤类似物，是一种 Polo 样激酶 1 (Plk1) 抑制剂。在表达类似物敏感的 Plk1 等位基因的细胞中，3MB-PP1 通过靶向 Plk1 阻断有丝分裂进程和细胞分裂。3MB-PP1 特异性抑制类似物敏感的 Ssn3 (Cdk8)。3MB-PP1 抑制 Leu93 突变 Zipper-interacting protein kinase(Leu93-ZIPK)，IC50为2 μM。3MB-PP1 可用于细胞分裂和白色念珠菌 (Candida albicans) 菌丝形成的研究。
T6081	Milciclib PHA-848125	Trk receptor; CDK; Autophagy	Autophagy; Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors
	Milciclib (PHA-848125) 是一种 ATP 竞争性的 CDK 和原肌球蛋白受体激酶双重抑制剂，作用于 CDK2，IC50 为 45 nM。
T10736	CDK4/6-IN-2	CDK	Cell Cycle/Checkpoint
	CDK4/6-IN-2 是一种CDK4和CDK6抑制剂，IC50分别为 2.7 和 16 nM。
TQ0078	CDK-IN-2 CDK inhibitor II	CDK	Cell Cycle/Checkpoint
	CDK-IN-2 (CDK inhibitor II) 是一种有效且特异性的 CDK9 抑制剂，IC50小于8 nM。
T10096L	Voruciclib	CDK	Cell Cycle/Checkpoint
	Voruciclib 是一种具有口服活性和选择性 CDK 抑制剂，Ki 为 0.626 nM-9.1 nM。它在多种弥漫性大 B 细胞淋巴瘤模型中抑制 MCL-1 的表达。它有效阻断 MCL-1 的转录调节子 CDK9。
T36694	XY028-140 XY028-140	CDK; PROTACs	Cell Cycle/Checkpoint; PROTAC
	XY028-140 是一种特异性 CDK4/CDK6 降解，抑制 CDK4/6 在癌细胞中的表达和活性。 XY028-140 是一种 PROTAC，由 Cereblon 配体和 CDK 配体相连接。
T9615	CK7	CDK	Cell Cycle/Checkpoint
	CK7是有效的Cdk2/9抑制剂。CK7可用于合成 Nek1 抑制剂 BSc5231 和BSc5367。

化合物

Cat.No: T60025

Target: CDK

Cat.No: T5673

Target: CDK

Cat.No: T7789

Target: HIV Protease

Cat.No: T5358

Target: ERK, Casein Kinase, CDK

Cat.No: T7426

Target: Apoptosis, GSK-3, CDK

Cat.No: T6312

Synonym: Ro 4584820

Target: Apoptosis, GSK-3, PKA, CDK

Cat.No: T2029

Target: ERK, CDK

Cat.No: T16359

Target: CDK, Aurora Kinase

Cat.No: T5395

Target: CDK, PROTACs

Cat.No: T2356

Target: Apoptosis, ERK, SGK, PKA, CDK, PKC

Cat.No: T39957

Target: CDK

Cat.No: TQ0266

Target: CDK

Cat.No: T8801

Target: CDK

Cat.No: T10436

Target: CDK

Cat.No: T4482

Target: Others, CDK

Cat.No: T16391

Target: CDK

Cat.No: T14901

Target: CDK

Cat.No: T6126

Synonym: JNJ 7706621

Target: Apoptosis, CDK, Aurora Kinase

Cat.No: TQ0060

Target: Apoptosis, CDK

Cat.No: T3352

Target: cholecystokinin, Casein Kinase, Pim, CDK

Cat.No: T4293

Target: CDK

Cat.No: T8484

Target: CDK

Cat.No: T14916

Target: CDK

Cat.No: T8378

Target: CDK, STAT

Cat.No: T8325

Target: Apoptosis, CDK

Cat.No: T16021

Target: CDK, Ras

Cat.No: T2506

Synonym: AZD5438

Target: CDK

Cat.No: T6167

Target: Apoptosis, p38 MAPK, CDK, PKC, Autophagy

Trilaciclib hydrochloride

Cat.No: T13202

Synonym: G1T28 hydrochloride

Target: CDK

Riviciclib hydrochloride

Cat.No: T6924

Synonym: P276-00

Target: Apoptosis, CDK

Cat.No: T7810

Synonym: LY-3177833

Target: CDK

Cat.No: T21966

Target: GSK-3, Aryl Hydrocarbon Receptor, CDK

Cat.No: T11929

Target: Phosphatase

Cat.No: T6205

Target: Apoptosis, GSK-3, CDK

Cat.No: T17069

Target: CDK, PROTACs

Cat.No: T9849

Target: CDK, Molecular Glues

Cat.No: T16363

Target: Apoptosis, CDK

Cat.No: T2113

Synonym: PHA 793887,PHA793887

Target: Apoptosis, CDK

Cat.No: TQ0053

Synonym: CYC065

Target: CDK

(±)-Enitociclib

Cat.No: T13467

Synonym: (±)-BAY-1251152

Target: CDK

Lerociclib dihydrochloride

Cat.No: T11345L

Synonym: G1T38 dihydrochloride

Target: CDK

Cat.No: T9117

Target: CDK, PROTACs

Cat.No: T10744L

Target: CDK

Cat.No: T21678

Target: PLK

Cat.No: T6081

Synonym: PHA-848125

Target: Trk receptor, CDK, Autophagy

Cat.No: T10736

Target: CDK

Cat.No: TQ0078

Synonym: CDK inhibitor II

Target: CDK

Cat.No: T10096L

Target: CDK

Cat.No: T36694

Synonym: XY028-140

Target: CDK, PROTACs

Cat.No: T9615

Target: CDK

Cat. No.	Product Name	Target	Signaling Pathways
T5S1467	Cucurbitacin E	CDK; Autophagy	Autophagy; Cell Cycle/Checkpoint
	Cucurbitacin E 是从黄瓜的攀缘茎中分离得到的一种天然产物。它显着抑制细胞周期蛋白B1/CDC2复合物的活性，具有预防神经变性，具有强效的抗增殖、抗肿瘤、抗炎和镇痛作用行动。
T16324	Nimbolide	Apoptosis; NF-κB; CDK	Apoptosis; Cell Cycle/Checkpoint; NF-κB
	Nimbolide 是源自印楝叶和花的一种三萜。它抑制CDK4/CDK6激酶活性。它抑制 NF-κB，Wnt，PI3K-Akt，MAPK 和 JAK-STAT 信号通路。它通过抑制NF-κB 而诱导肿瘤细胞凋亡。
T2933	Wogonin Vogonin,汉黄芩素	Apoptosis; Wnt/beta-catenin; CDK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Wogonin (Vogonin) 是一种具有细胞渗透性的口服类黄酮，具有抗炎和抗癌特性，能够抑制 CDK8和 Wnt 的活性。
TN1673	Garcinone C 伽升沃 C,伽升沃C	ATM/ATR; CDK; STAT; AChR; Antifection	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Garcinone C 是一种从 Garcinia oblongifolia Champ 中提取的黄酮衍生物，具有抗炎、收敛和促进肉芽的活性。 Garcinone C 是一种 AChE 抑制剂，对某些癌症具有潜在的细胞毒性作用。
TN1299	Desmethylglycitein 4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone	PI3K; CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物，具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂，抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2，抑制 CDK1 和 CDK2 活性。
T7444	6-(Dimethylamino)purine N,N-Dimethyladenine,6-二甲基氨基嘌呤	Serine/threonin kinase; CDK	Cell Cycle/Checkpoint; Metabolism
	6-(Dimethylamino)purine (N,N-Dimethyladenine) 是一种丝氨酸苏氨酸蛋白激酶和 CDK 抑制剂。
T17143	Toyocamycin 丰加霉素,Vengicide	Apoptosis; Others; IRE1; Antibiotic; Antifungal	Apoptosis; Cell Cycle/Checkpoint; Microbiology/Virology; Others
	Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物，为 X 盒结合蛋白 1 (XBP1) 抑制剂，抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂，IC50值为 80 nM。它还诱导凋亡。
T7060	Amantadine 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine	Others	Others
	Amantadine (1-Aminoadamantane) 是抗病毒药物，也是是 NMDA 型谷氨酸受体的弱拮抗剂，能促进高多巴胺的释放，并阻断多巴胺的再摄取。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
T6169	Indirubin Indigopurpurin,Indigo red,NSC 105327,Couroupitine B,靛玉红	Apoptosis; Raf; GSK-3; CDK	Apoptosis; Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	Indirubin (Couroupitine B) 是一种具有抗炎症和抗癌活性的天然产物。
TN3673	Clausine Z	CDK	Cell Cycle/Checkpoint
	Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
TMA1012	Ganoderiol F	Androgen Receptor; HIV Protease; Autophagy	Autophagy; Endocrinology/Hormones; Microbiology/Virology; Proteases/Proteasome
	Ganoderiol F has anti-inflammatory, cytotoxic and anti-HIV activity, it inhibits activity of topoisomerases in vitro, and it inhibits human immunodeficiency virus-1 protease with IC(50) values of 20-40 microM. It induced HO-1 expression, activation of the mitogen-activated protein kinase EKR and up-regulation of cyclin-dependent kinase inhibitor p16 and suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) production.

天然产物

Cat.No: T5S1467

Target: CDK, Autophagy

Cat.No: T16324

Target: Apoptosis, NF-κB, CDK

Cat.No: T2933

Synonym: Vogonin,汉黄芩素

Target: Apoptosis, Wnt/beta-catenin, CDK, Autophagy

Cat.No: TN1673

Synonym: 伽升沃 C,伽升沃C

Target: ATM/ATR, CDK, STAT, AChR, Antifection

Desmethylglycitein

Cat.No: TN1299

Synonym: 4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone

Target: PI3K, CDK, PKC

6-(Dimethylamino)purine

Cat.No: T7444

Synonym: N,N-Dimethyladenine,6-二甲基氨基嘌呤

Target: Serine/threonin kinase, CDK

Cat.No: T17143

Synonym: 丰加霉素,Vengicide

Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal

Cat.No: T7060

Synonym: 1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine

Target: Others

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: T6169

Synonym: Indigopurpurin,Indigo red,NSC 105327,Couroupitine B,靛玉红

Target: Apoptosis, Raf, GSK-3, CDK

Cat.No: TN3673

Target: CDK

Cat.No: TMA1012

Target: Androgen Receptor, HIV Protease, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04548	CDK4 Protein, Human, Recombinant (GST) CMM3,PSK-J3,cyclin-dependent kinase	Human	Baculovirus Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser...
TMPY-04556	CDK5 Protein, Human, Recombinant (GST) PSSALRE,cyclin-dependent kinase 5	Human	Baculovirus Insect Cells
	Cell division protein kinase 5, also known as Cyclin-dependent kinase 5, Serine/threonine-protein kinase PSSALRE, Tau protein kinase II catalytic subunit, TPKII catalytic subunit and CDK5, is a cytoplasm protein which belongs to theprotein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2 / CDKX subfamily. Cyclin-dependent kinases (Cdks) are a family of proline-directed Ser/Thr kinases known for their role in the control of cell cycle progression. In 1992, this family was jo...
TMPJ-00972	CDKN1B Protein, Human, Recombinant (His) KIP1,CDKN1B,Cyclin-Dependent Kinase	Human	E. coli
	Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B) is a Kinesin-related motor protein necessary for mitotic spindle assembly and chromosome segregation. CDKN1B is expressed in all tissues with highest levels observed in skeletal muscle. CDKN1B is a potent inhibitor of Cyclin E- and Cyclin A-CDK2 complexes. CDKN1B forms a complex with Cyclin Type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. In addition, CDKN1B acts as an inhibitor or an ...
TMPJ-00963	CDKN2C Protein, Human, Recombinant (His) Cyclin-Dependent Kinase 4 Inhibit...	Human	E. coli
	Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) is a member of the INK4 family of cyclin dependent kinase inhibitors. CDKN2C contains 4 ANK repeats and interacts with CDK4 or CDK6. Highest levels of CDKN2C can be found in skeletal muscle, pancreas, and heart. CDKN2C inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB and prevent the activation of the CDK kinases. Studies have been shown the roles of CDKN2C gene in regulating spermatogenesis,...
TMPY-04542	CDK2 Protein, Human, Recombinant (His) CDKN2,cyclin-dependent kinase 2,p...	Human	Baculovirus Insect Cells
	CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. Cdks (cyclin-dependent kinases) are heteromeric serine/threonine kinases that control progression through the cell cycle in concert with their regulatory subunits, the c...
TMPY-04549	CDK1 Protein, Human, Recombinant (GST) CDC2,P34CDC2,CDC28A,cyclin-dependent k...	Human	Baculovirus Insect Cells
	CDK1 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 60 kDa and the accession number is P06493-1.
TMPY-04463	CDKL2 Protein, Human, Recombinant (His) KKIAMRE,P56,cyclin-dependent kinase	Human	Baculovirus Insect Cells
	Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus, amygdala, and dorsal thalamus. The high expression in these brain regions suggests that Cdkl2 may have functions in congnition and emotion processes. Cdkl2 accumulates primarily in the cytoplasm, with lower levels in the nucleus.
TMPY-02921	CDK2AP2 Protein, Human, Recombinant (His) DOC-1R,p14,cyclin-dependent kinase	Human	E. coli
	CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative las...
TMPY-04775	CDK1 Protein, Mouse, Recombinant (His & GST) CDC2>,Cdc2,Cdc2a,p34<,cyclin-dependent...	Mouse	Baculovirus Insect Cells
	CDK1 Protein, Mouse, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 61.9 kDa and the accession number is P11440.
TMPY-04776	PCTAIRE1 Protein, Human, Recombinant (GST) cyclin-dependent kinase 16,PCTAIR...	Human	Baculovirus Insect Cells
	PCTAIRE1 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 82 kDa and the accession number is Q00536-1.
TMPY-02495	p19 INK4d Protein, Human, Recombinant (GST) p19-INK4D,INK4D,cyclin-dependent kinas...	Human	E. coli
	Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S transition by phosphorylating the retinoblastoma tumor-suppressor gene product. It is clearly shown that DNA repair is the main target of p19ink4d effect and that diminished apoptosis is a downstream event. Experiments has uncovered a role of p19INK4d as a regulator of DNA-damage-ind...
TMPH-01170	CDK5R1 Protein, Human, Recombinant (His) CDK5 activator 1,CDK5R,NCK5A,CDK5R1,Cyclin-depe...	Human	E. coli
	CDK5R1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-00081	CDKB1-2 Protein, Arabidopsis thaliana, Recombinant (His) CDKB1-2,CDKB1;2,Cyclin-dependent kinas...	Arabidopsis thaliana	P. pastoris (Yeast)
	Together with CDKB1-1, promotes both the last division in the stomatal cell lineage as well as the number of stomata. In collaboration with MYB124 and MYB88, restrict the G1/S transition and chloroplast and nuclear number during stomatal formation, and normally maintain fate and developmental progression throughout the stomatal cell lineage. CDKB1-2 Protein, Arabidopsis thaliana, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 37.6 kDa and the accessio...
TMPH-01169	CDK4 Protein, Human, Recombinant (His) Cyclin-dependent kinase 4,CDK4,Ce...	Human	E. coli
	CDK4 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01171	CDK5 Protein, Human, Recombinant Serine/threonine-protein kinase PSSALRE,Cyclin<...	Human	E. coli
	CDK5 Protein, Human, Recombinant is expressed in E. coli.
TMPY-04449	CDK7 & CCNH & MNAT1 Protein, Human, Recombinant (His) HCAK,CAK1,cyclin-dependent kinase...	Human	Baculovirus Insect Cells
	CDK7 & CCNH & MNAT1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 118.8 kDa and the accession number is P50613&P51946&P51948.
TMPH-01167	CDK1 Protein, Human, Recombinant (His) p34 protein kinase,Cell division control protein 2 ...	Human	E. coli
	CDK1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01168	CDKN2B Protein, Human, Recombinant (His & Myc) Multiple tumor suppressor 2,Cyclin-dependent	Human	E. coli
	CDKN2B Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-01173	CDK7 Protein, Human, Recombinant Cyclin-dependent kinase 7,Cell di...	Human	E. coli
	CDK7 Protein, Human, Recombinant is expressed in E. coli.
TMPH-01172	CDK7 Protein, Human, Recombinant (His) 39 kDa protein kinase,Cyclin-dependent...	Human	Baculovirus Insect Cells
	CDK7 Protein, Human, Recombinant (His) is expressed in Baculovirus.
TMPY-01401	Cyclin A1 Protein, Human, Recombinant (His) cyclin A1,CT146	Human	Baculovirus Insect Cells
	Cyclin A1 is a member of the highly conserved cyclin family that is characterized by a dramatic periodicity in protein abundance, and belongs to the A-type cyclin subfamily. The mammalian A-type cyclin family consists of two members: cyclin A1 and cyclin A2. Different cyclins exhibit distinct expression. Cyclin A1 is expressed in mice exclusively in the germ cell lineage and high rate of cyclinA1 is found in human testis and certain myeloid leukaemia cells. Cyclin A1 is primarily function in the...
TMPH-03264	p53 Protein, Rat, Recombinant (His) Tumor suppressor p53,Tp53,Cellular tumor antigen p53	Rat	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex...
TMPH-02574	p53 Protein, Mouse, Recombinant (His & SUMO) Tp53,Cellular tumor antigen p53,Tumor suppressor p53	Mouse	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 ex...

重组蛋白

CDK4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04548

Species: Human

Expression System: Baculovirus Insect Cells

CDK5 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04556

Species: Human

Expression System: Baculovirus Insect Cells

CDKN1B Protein, Human, Recombinant (His)

Cat.No: TMPJ-00972

Species: Human

Expression System: E. coli

CDKN2C Protein, Human, Recombinant (His)

Cat.No: TMPJ-00963

Species: Human

Expression System: E. coli

CDK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04542

Species: Human

Expression System: Baculovirus Insect Cells

CDK1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04549

Species: Human

Expression System: Baculovirus Insect Cells

CDKL2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04463

Species: Human

Expression System: Baculovirus Insect Cells

CDK2AP2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02921

Species: Human

Expression System: E. coli

CDK1 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04775

Species: Mouse

Expression System: Baculovirus Insect Cells

PCTAIRE1 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04776

Species: Human

Expression System: Baculovirus Insect Cells

p19 INK4d Protein, Human, Recombinant (GST)

Cat.No: TMPY-02495

Species: Human

Expression System: E. coli

CDK5R1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01170

Species: Human

Expression System: E. coli

CDKB1-2 Protein, Arabidopsis thaliana, Recombinant (His)

Cat.No: TMPH-00081

Species: Arabidopsis thaliana

Expression System: P. pastoris (Yeast)

CDK4 Protein, Human, Recombinant (His)

Cat.No: TMPH-01169

Species: Human

Expression System: E. coli

CDK5 Protein, Human, Recombinant

Cat.No: TMPH-01171

Species: Human

Expression System: E. coli

CDK7 & CCNH & MNAT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04449

Species: Human

Expression System: Baculovirus Insect Cells

CDK1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01167

Species: Human

Expression System: E. coli

CDKN2B Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01168

Species: Human

Expression System: E. coli

CDK7 Protein, Human, Recombinant

Cat.No: TMPH-01173

Species: Human

Expression System: E. coli

CDK7 Protein, Human, Recombinant (His)

Cat.No: TMPH-01172

Species: Human

Expression System: Baculovirus Insect Cells

Cyclin A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01401

Species: Human

Expression System: Baculovirus Insect Cells

p53 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03264

Species: Rat

Expression System: E. coli

p53 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02574

Species: Mouse

Expression System: E. coli

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼