首页工具

登录

搜索结果

Search Results for " non–small-cell lung cancer "

Targets Recommended: VEGFR

137

抑制剂 & 化合物

17

天然产物

1

化合物库

12

重组蛋白

4

同位素标记化合物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L2190	抗肺癌化合物库		1702 compounds
	1702 种与肺癌相关的化合物，可以用于抗肺癌药物研发和药理研究；

化合物库

抗肺癌化合物库

Cat.No: L2190

Compounds: 1702

Cat. No.	Product Name	Target	Signaling Pathways
T9929	Ramucirumab	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Ramucirumab 是一种人 VEGFR-2 拮抗剂，具有抗实体瘤活性。它是人源化单克隆抗体，能够与 VEGFR-2 结合，阻碍 VEGFR 配体 VEGF-A，VEGF-C 和 VEGF-D 结合。
T10777	CG347B	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	CG347B 是一种选择性HDAC6抑制剂。
T21588	Olomoucine	ERK; CDK	Cell Cycle/Checkpoint; MAPK
	Olomoucine 是 Cdk2/cyclin A、Cdc2/CyclinB、CDK2/CyclinE、CDK5/p35 和 ERK1/p44 MAP 激酶的 ATP 竞争性抑制剂，IC50 分别为 7、7、7、3 和 25 µM。 Olomoucine 调节细胞周期并表现出抗黑色素肿瘤活性。
T2325	Neratinib HKI-272,来那替尼	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Neratinib (HKI-272) 是一种酪氨酸激酶受体抑制剂，可以抑制 HER2 和 EGFR (IC50=59/92 nM)，具有不可逆性和口服活性。Neratinib 具有抗肿瘤活性，可以用于治疗乳腺癌。
T9865	Almonertinib mesylate	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Almonertinib mesylate 是一种不可逆的 EGFR 酪氨酸激酶抑制剂，对 EGFR 敏感突变和 T790M 耐药突变具有高选择性。它可用于非小细胞肺癌研究。
T8756	KRAS inhibitor-9 DUN09716	Apoptosis; Ras	Apoptosis; GPCR/G Protein; MAPK
	KRAS inhibitor-9 (DUN09716) 是一种 KRAS 抑制剂，阻止 GTP-KRAS 的形成和 KRAS 下游激活。它以中等的结合亲和力与 KRAS G12D、KRAS G12C 和 KRAS Q61H 蛋白结合，选择性抑制具有 KRAS 突变的 NSC-LC 细胞的增殖。它可导致 G2/M 细胞周期停滞并诱导凋亡。
T60076	Oritinib SH-1028	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Oritinib (SH-1028) 是一种 EGFR 抑制剂，对 EGFR (wt)、EGFR (L858R)、EGFR (L861Q)、EGFR (L858R/T790M)、EGFR (d746-750) 的 IC50 分别为 18、0.7、4、0.1、1.4 和 0.89 nM , EGFR (d746-750/T790M), 分别。奥瑞替尼可用于治疗非小细胞肺癌的研究。
T5462	Almonertinib HS-10296,阿美替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Almonertinib (HS-10296) 是EGFR 激活突变抑制剂和EGFR T790M 耐受突变抑制剂，对 EGFR 致敏和 T790M 耐药突变具有高选择性，用于非小细胞肺癌的研究。它对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性，对野生型的抑制作用较弱。
T8656	CAY10404 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T	Apoptosis; Akt; COX	Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Neuroscience; PI3K/Akt/mTOR signaling
	CAY10404 (3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T) 是一种有效且高度选择性的 COX-2 和 COX-1 抑制剂。它还是 PKB/Akt 和 MAPK 信号通路的有效抑制剂，可诱导 NSC-LC 细胞凋亡，具有镇痛、抗炎和抗癌活性。
T0373	Erlotinib OSI-744,NSC 718781,CP358774,埃罗替尼,R1415	EGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Erlotinib (CP358774) 是一种 EGFR 一代抑制剂，抑制 EGFR 19 Del 和 L858R 突变。Erlotinib 具有抗肿瘤活性，用于治疗 EGFR 突变的非小细胞肺癌。Erlotinib 用药会产生 EGFR C797S 耐药突变。
T5675	Almonertinib hydrochloride HS-10296 hydrochloride,盐酸阿美替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Almonertinib hydrochloride (HS-10296 hydrochloride) 是一种 EGFR 激活突变和 T790M 耐药突变的小分子抑制剂，用于非小细胞肺癌的研究，对 T790M、T790M/L858R 和 T790M/Del19 表现出较强的抑制活性，对野生型的抑制作用较弱。
T1758	ABT-751 E7010	Microtubule Associated; Autophagy	Autophagy; Cytoskeletal Signaling
	ABT-751 (E7010) 是一种新型的生物相容性的微管蛋白结合剂，用于治疗肺癌、非小细胞肺癌和非小细胞肺癌。它是磺胺类抗有丝分裂抑制剂，对神经母细胞瘤细胞株和非神经母细胞瘤细胞株的IC50分别为1.5 和 3.4 μM。
T15390	Glufosfamide D 19575,Glucosylifosfamide mustard	Others	Others
	Glufosfamide 是一种新型噁唑磷胺化合物，具有抗癌活性，可用于研究晚期非小细胞肺癌。
T36404L	PRLX-93936 HCL PRLX-93936 hcl(903499-49-0 Free base)	Ferroptosis; Reactive Oxygen Species	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB
	PRLX-93936 HCL 是 erastin 的类似物，并显示出与顺铂对非小细胞肺癌 (NSCLC) 细胞的协同作用。
T39275	Befotertinib D-0316,Befotertinib	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Befotertinib (D-0316) 是一种 EGFR 酪氨酸激酶抑制剂，可用于 EGFR T790M 阳性非小细胞肺癌的研究。
T30087	Antroquinonol	Reactive Oxygen Species; Nrf2	Immunology/Inflammation; Metabolism; NF-κB
	Antroquinonol 是一种来源于 Antrodia camphorata 的泛醌衍生物，具有抗炎和抗癌活性。Antroquinonol 通过增强 Nrf2 信号通路降低氧化应激，抑制局灶节段性肾小球硬化小鼠的炎症和硬化。Antroquinonol 具有治疗非小细胞肺癌的潜力，可用于结肠癌的研究。
T67934	MRT-2359	Others	Others
	MRT-2359 是一种有效的且可口服的 GSPT1 降解剂，具有抗肿瘤活性。MRT-2359 对耐药非小细胞肺癌 (NSCLC) 和小细胞肺癌 (SCLC) 细胞的生长具有抑制作用。MRT-2359 在 MYC 驱动的细胞系中表现出优先活性。
T0373L	Erlotinib hydrochloride 盐酸埃罗替尼,OSI-744,NSC 718781,Erlotinib HCl,CP-358774	EGFR; Autophagy	Angiogenesis; Autophagy; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Erlotinib hydrochloride (NSC 718781) 抑制EGFR 激酶的IC50为 2 nM，用于治疗非小细胞肺癌。
T9673	RET-IN-3	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	RET-IN-3 是一种具有选择性和高效性的 RETV804M 激酶抑制剂，具有潜在抗癌活性,可用于研究非小细胞肺癌。
T39764	KER047 ALK2-IN-4	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	KER047 (ALK2-IN-4) 是一种 ALK2 抑制剂，具有潜在的抗癌活性，可用于研究非小细胞肺癌。
T13564L2	AZ7550 trimesylate salt AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)	MLK	MAPK
	AZ7550 trimesylate salt (AZ7550 Mesylate) 是奥希替尼的活性代谢产物，AZ7550 trimesylate salt 抑制 IGF1R 活性，可用于研究非小细胞肺癌。
T6084	Rabusertib LY2603618,IC-83	Chk; PDK; Autophagy	Autophagy; Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling
	Rabusertib (IC-83) 是一种有效的选择性的Chk1抑制剂，IC50为 7 nM。它有潜在的化学增强活性，用于各种癌症和肿瘤治疗的试验。
T72043	SCFSkp2-IN-2	Apoptosis; E1/E2/E3 Enzyme	Apoptosis; Ubiquitination
	SCFSkp2-IN-2 是一种 Skp2抑制剂，其 KD 为 28.77 μM。AAA-237 诱导 NSCLC 细胞凋亡 (apoptosis)，显示出抗肿瘤活性。
T76792	Sibrotuzumab BIBH 1,Anti-Human FAP Recombinant Antibody	Others	Others
	Sibrotuzumab (BIBH 1) 是一种靶向成纤维细胞激活蛋白 (FAP)的人源化 IgG1 单克隆抗体。Sibrotuzumab 可用于研究结直肠癌和非小细胞肺癌。
T74982	Akt3 degrader 1	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Akt3 degrader 1 是一种特异性 Akt3 降解剂，具有抗癌抗增殖活性，可抑制小鼠体内肿瘤的生长。Akt3 degrader 1 可用于研究非小细胞肺癌和胰腺癌。
T9901A-002	Enoblituzumab MGA271,TJ-271	Others	Others
	Enoblituzumab 是一种人源化 IgG1κ 单克隆抗体，可以识别人 B7-H3 蛋白，可用于研究非小细胞肺癌（NSCLC）等实体肿瘤。
T40292	Opnurasib NVP-JDQ443,JDQ-443,Opnurasib	Ras	GPCR/G Protein; MAPK
	Opnurasib (JDQ-443) 是一种可口服且具有选择性和有效性的共价 KRAS G12C 抑制剂，具有抗肿瘤活性，可用于研究晚期非小细胞肺癌。
T35901	EGFR-IN-99 JBJ-03-142-02	EGFR; HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-99 (JBJ-03-142-02) 是一种 EGFR 和 HER2 Exon 20 插入突变抑制剂，具有抗增殖活性，可用于研究非小细胞肺癌 (NSCLC) 。
T78156	MC4033	Apoptosis; Histone Acetyltransferase	Apoptosis; Chromatin/Epigenetic
	MC4033 是一种选择性的赖氨酸乙酰转移酶8 (KAT8) 抑制剂（IC50：12.1 μM），具有抗癌作用，可诱导凋亡，可用于研究非小细胞肺癌。
T61016	EMI1	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EMI1 是 EGFR 三重突变体 (EGFR ex19del/T790M/C797S, EGFR L858R/T790M/C797S) 的有效抑制剂。EMI1 可用于 EGFR 突变相关的耐药型非小细胞肺癌 (NSCLC) 的研究。
T64028	Iruplinalkib WX-0593	ALK; ROS Kinase	Angiogenesis; Tyrosine Kinase/Adaptors
	Iruplinalkib (WX-0593) 是一种具有口服活性、选择性和高效性的 ALK 和 ROS1 酪氨酸激酶抑制剂，具有抗癌活性，可用于研究非小细胞肺癌。
T35391	Vibostolimab (anti-TIGIT) Vibostolimab (anti-TIGIT)	Others	Others
	Vibostolimab 是一种抗 T 细胞免疫蛋白和 ITIM 域的单克隆抗体。Vibostolimab 在体外实验中显示出抗肿瘤活性，可用于研究非小细胞肺癌 (NSCLC) 和黑色素瘤。
T35916	Simotinib AL-6802,SIM-6802	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Simotinib (AL-6802) 是一种具有选择性和口服生物活性的 EGFR 酪氨酸激酶抑制剂（ IC50 ：19.9 nM），具有抗肿瘤活性，可用于研究非小细胞性肺癌。
T9460	iMDK	PI3K	PI3K/Akt/mTOR signaling
	iMDK 是PI3K 抑制剂，能够抑制生长因子MDK。它能够与 MEK 抑制剂协同抑制非小细胞肺癌，而不会伤害正常细胞和小鼠。
T36316	mTOR inhibitor-8 mTOR-IN-8	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	mTOR inhibitor-8 是一种有效的 mTOR 抑制剂和自噬诱导剂，具有抗病毒和抗肿瘤活性。mTOR inhibitor-8 抑制A549细胞的生长，可用于研究非小细胞肺癌。
T35394	Sintilimab (anti-PD-1) IBI308,Sintilimab (anti-PD-1)	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Sintilimab (IBI308) 是一种人源化的 IgG4 单克隆抗体，具有显著的抗肿瘤活性，通过与 PD-1 结合从而阻断 PD-1 与其配体 (PD-L1 和 PL-L2) 的相互作用，进而恢复内源性抗肿瘤 T 细胞反应。Sintilimab 联合其他化合物来治疗经典霍奇金淋巴瘤、非小细胞肺癌和食管癌。
T9754	BLU-945 BLU945,BLU 945	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BLU-945 是一种强效的、高选择性的、口服有效的、可逆的表皮生长因子受体酪氨酸激酶抑制剂 (TKIs)。BLU-945 可有效抑制具有 L858R 和/或外显子 19 缺失突变、T790M 突变和 C797S 突变的 EGFR。BLU-945 可用于肺癌包括非小细胞肺癌（NSCLC）的研究。
T60039	KSQ-4279 USP1-IN-1	PARP; DUB	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Ubiquitination
	KSQ-4279 (USP1-IN-1)是 USP1 和 PARP 的抑制剂。KSQ-4279 具有抗癌活性，可用于研究非小细胞肺癌、骨肉瘤、卵巢癌、乳腺癌、胶质母细胞瘤、膀胱癌、子宫癌和胰腺癌。
T76796	Patritumab U3-1287,AMG-888	ERK; EGFR; Akt; HER	Angiogenesis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Patritumab（U3-1287）是抗 HER3 单克隆抗体，具有潜在的抗肿瘤活性，对 EGFR，HER2，HER3，ERK 和 AKT 的磷酸化有抑制作用和。Patritumab 促使细胞凋亡 (apoptosis)，抑制非小细胞肺癌的增殖。
T35392	Tiragolumab RO 7092284,RG6058-10,MTIG-7192A,RG6058-11,RG-6058	Others	Others
	Tiragolumab(MTIG-7192A) 是一种靶向 T 细胞免疫球蛋白和 ITIM 结构域 (TIGIT) 的单克隆抗体。Tiragolumab (anti-TIGIT) 常与 PD-L1 抑制剂 Atezolizumab 联合使用用来治疗像非小细胞肺癌类的实体恶性肿瘤。
T14997	Conteltinib SY-707,CT-707	FAK; PYK2; ALK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Conteltinib (CT-707) 是一种靶向FAK、ALK 和 Pyk2 的酶抑制剂，具有抗肿瘤活性。Conteltinib 对 FAK 有明显的抑制作用，通过抑制 YAP 信号传导来克服肝细胞癌中缺氧介导的索拉非尼耐药性，可用于晚期 ALK 阳性非小细胞肺癌和淋巴癌。
T72784	OTUB1/USP8-IN-1	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	OTUB1/USP8-IN-1 是一种高效的 OTUB1/USP8 抑制剂，具有潜在的抗癌活性，对 OTUB1 和 USP8 的 IC50 值分别为 0.17 和 0.28 nM。OTUB1/USP8-IN-1 可用于研究非小细胞肺癌。
T22443	Triglycidyl isocyanurate Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI	Apoptosis	Apoptosis
	Triglycidyl isocyanurate (Teroxirone) 是一种三氮烯三环氧化合物，可通过 p53的激活抑制非小细胞肺癌细胞的生长。它诱导细胞凋亡，具有抗血管生成和抗肿瘤活性，用于癌症研究。
T2490	Osimertinib AZD-9291,Mereletinib,奥希替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Osimertinib (AZD-9291) 是一种 EGFR 三代抑制剂，抑制二代 EGFR 抑制剂产生的 T790M 耐药突变，具有不可逆性和口服活性。Osimertinib 具有抗肿瘤活性，用于治疗 EGFR 突变的非小细胞肺癌。
T76703	Tislelizumab VDT-482,BGB-A317	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Tislelizumab (BGB-A317) 是一种靶向人程序性死亡受体-1（PD-1）IgG4类单克隆抗体，具有抗肿瘤活性，抑制 Fcγ 受体与巨噬细胞的结合，可用于研究晚期鳞状非小细胞肺癌。
T72953	Zidesamtinib NVL-520	ROS Kinase	Tyrosine Kinase/Adaptors
	Zidesamtinib (NVL-520)是一种具有口服活性、选择性、高效性和可透过血脑屏障的 ROS1 融合和抗性突变抑制剂，抑制 ROS1 和 ROS1 G2032R ，可用于研究非小细胞肺癌和实体瘤。
T63343	ULK1-IN-2	Apoptosis; Autophagy	Apoptosis; Autophagy
	ULK1-IN-2 是一种有效的 ULK1 抑制剂，具有潜在的抗癌活性，可诱导细胞凋亡同时阻断自噬。ULK1-IN-2 对癌细胞具有较高的细胞毒作用，对 A549 细胞的 IC50 值为 1.94 μM。ULK1-IN-2 可用于研究非小细胞肺癌。
T77401	Bavituximab Anti-PS MAb 3G4	Others	Others
	Bavituximab (Anti-Human Phosphatidylserine Recombinant Antibody) 是一种针对磷脂酰丝氨酸 (PS) 的单克隆抗体，具有血管靶向和免疫调节特性，能够重新激活抗肿瘤免疫来抑制肿瘤生长。Bavituximab 具有抗癌活性，常联合Paclitaxel 和 Carboplatin 来研究非小细胞肺癌。
T61575	USP15-IN-1	DUB	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Ubiquitination
	USP15-IN-1 是一种有效的 USP15 抑制剂（IC50 为 3.76 μM）。USP15-IN-1对非小细胞肺癌和白血病细胞具有高度的抗增殖活性。USP15是 cGAS 的互作蛋白，并且 USP15可以促进 cGAS 识别DNA 激活下游信号通路。
T83626	YS-67	Apoptosis; EGFR; Akt	Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	YS-67 是一种可口服且具有选择性和高效性的 EGFR 抑制剂，具有抗肿瘤活性，抑制 p-EGFR 和 p-AKT，抑制 A549、PC-9 和 A431 细胞的增殖。YS-67在 G0/G1 期阻止细胞周期进程并诱导细胞凋亡，可用于研究非小细胞肺癌。

化合物

Cat.No: T9929

Target: VEGFR

Cat.No: T10777

Target: HDAC

Cat.No: T21588

Target: ERK, CDK

Cat.No: T2325

Synonym: HKI-272,来那替尼

Target: EGFR, HER

Almonertinib mesylate

Cat.No: T9865

Target: EGFR

KRAS inhibitor-9

Cat.No: T8756

Synonym: DUN09716

Target: Apoptosis, Ras

Cat.No: T60076

Synonym: SH-1028

Target: EGFR

Cat.No: T5462

Synonym: HS-10296,阿美替尼

Target: EGFR

Cat.No: T8656

Synonym: 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T

Target: Apoptosis, Akt, COX

Cat.No: T0373

Synonym: OSI-744,NSC 718781,CP358774,埃罗替尼,R1415

Target: EGFR, Autophagy

Almonertinib hydrochloride

Cat.No: T5675

Synonym: HS-10296 hydrochloride,盐酸阿美替尼

Target: EGFR

Cat.No: T1758

Synonym: E7010

Target: Microtubule Associated, Autophagy

Cat.No: T15390

Synonym: D 19575,Glucosylifosfamide mustard

Target: Others

Cat.No: T36404L

Synonym: PRLX-93936 hcl(903499-49-0 Free base)

Target: Ferroptosis, Reactive Oxygen Species

Cat.No: T39275

Synonym: D-0316,Befotertinib

Target: EGFR

Cat.No: T30087

Target: Reactive Oxygen Species, Nrf2

Cat.No: T67934

Target: Others

Erlotinib hydrochloride

Cat.No: T0373L

Synonym: 盐酸埃罗替尼,OSI-744,NSC 718781,Erlotinib HCl,CP-358774

Target: EGFR, Autophagy

Cat.No: T9673

Target: c-RET

Cat.No: T39764

Synonym: ALK2-IN-4

Target: ALK

AZ7550 trimesylate salt

Cat.No: T13564L2

Synonym: AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)

Target: MLK

Cat.No: T6084

Synonym: LY2603618,IC-83

Target: Chk, PDK, Autophagy

Cat.No: T72043

Target: Apoptosis, E1/E2/E3 Enzyme

Cat.No: T76792

Synonym: BIBH 1,Anti-Human FAP Recombinant Antibody

Target: Others

Akt3 degrader 1

Cat.No: T74982

Target: Akt

Cat.No: T9901A-002

Synonym: MGA271,TJ-271

Target: Others

Cat.No: T40292

Synonym: NVP-JDQ443,JDQ-443,Opnurasib

Target: Ras

Cat.No: T35901

Synonym: JBJ-03-142-02

Target: EGFR, HER

Cat.No: T78156

Target: Apoptosis, Histone Acetyltransferase

Cat.No: T61016

Target: EGFR

Cat.No: T64028

Synonym: WX-0593

Target: ALK, ROS Kinase

Vibostolimab (anti-TIGIT)

Cat.No: T35391

Synonym: Vibostolimab (anti-TIGIT)

Target: Others

Cat.No: T35916

Synonym: AL-6802,SIM-6802

Target: EGFR

Cat.No: T9460

Target: PI3K

mTOR inhibitor-8

Cat.No: T36316

Synonym: mTOR-IN-8

Target: mTOR, Autophagy

Sintilimab (anti-PD-1)

Cat.No: T35394

Synonym: IBI308,Sintilimab (anti-PD-1)

Target: PD-1/PD-L1

Cat.No: T9754

Synonym: BLU945,BLU 945

Target: EGFR

Cat.No: T60039

Synonym: USP1-IN-1

Target: PARP, DUB

Cat.No: T76796

Synonym: U3-1287,AMG-888

Target: ERK, EGFR, Akt, HER

Cat.No: T35392

Synonym: RO 7092284,RG6058-10,MTIG-7192A,RG6058-11,RG-6058

Target: Others

Cat.No: T14997

Synonym: SY-707,CT-707

Target: FAK, PYK2, ALK

OTUB1/USP8-IN-1

Cat.No: T72784

Target: DUB

Triglycidyl isocyanurate

Cat.No: T22443

Synonym: Tris(2,3-epoxypropyl) Isocyanurate,Teroxirone,TGIC,1,3,5-三缩水甘油-S-三嗪三酮,TGI

Target: Apoptosis

Cat.No: T2490

Synonym: AZD-9291,Mereletinib,奥希替尼

Target: EGFR

Cat.No: T76703

Synonym: VDT-482,BGB-A317

Target: PD-1/PD-L1

Cat.No: T72953

Synonym: NVL-520

Target: ROS Kinase

Cat.No: T63343

Target: Apoptosis, Autophagy

Cat.No: T77401

Synonym: Anti-PS MAb 3G4

Target: Others

Cat.No: T61575

Target: DUB

Cat.No: T83626

Target: Apoptosis, EGFR, Akt

Cat. No.	Product Name	Target	Signaling Pathways
T2870	Matrine Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy; Ferroptosis; Opioid Receptor; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Matrine (Vegard) 是一种从槐属植物中分离出来的生物碱，可作为一种κ阿片受体激动剂，有抗肿瘤活性。
T25192	Butyrolactone I Olomoucin,丁酸内酯I	CDK	Cell Cycle/Checkpoint
	Butyrolactone I (Olomoucin) 是 CDK 和 cdc2 激酶家族的 ATP 竞争性抑制剂。 Butyrolactone I 在非小细胞肺、小细胞肺和前列腺癌细胞系中显示出抗肿瘤作用。
T7849	Norspermine	Others	Others
	Norspermine 是一种多胺类似物，用于治疗非小细胞肺癌和乳腺癌。
TN5254	Wighteone Erythrinin B,6-Isopentenylgenistein	Antifungal	Microbiology/Virology
	Wighteone (Erythrinin B) 是一种从 Genista ephedroides 中提取出来的小分子化合物，具有潜在的抗真菌和抗癌活性，对 EGFR L858R/T790M 突变非小细胞肺癌具有抗肿瘤作用。。
TN1721	Gypenoside L	ERK; p38 MAPK; Calcium Channel; NF-κB; ROS	Immunology/Inflammation; MAPK; Membrane transporter/Ion channel; Metabolism; NF-κB
	Gypenoside L 是存在于绞股蓝中的一种皂苷，可增加 SA-β-半乳糖苷酶活性，促进衰老相关分泌细胞因子的产生。它还可以激活p38和ERK MAPK 通路和NF-κB 通路以诱导衰老，具有抗肿瘤和抗炎活性。
TN3972	Epimedokoreanin B	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Epimedokoreanin B （EKB）是一种从韩国淫羊藿中分离出的异戊烯化类黄酮，在人非小细胞肺癌（NSCLC）A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性，可有清除 DPPH 自由基的活性，能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -（羧甲基）赖氨酸（CML）和 N (Ï) -（羧甲基）精氨酸（CMA）的形成，可通过抑制高级糖化终产物（AGEs）预防糖尿病的临床并发症。
TN3355	Agatharesinol acetonide	Antifection	Microbiology/Virology
	Agatharesinol acetonide shows anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM).
TN4355	Jolkinol A	Others	Others
	Jolkinol A can inhibit both MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM.
TN1642	Ferruginol 铁锈罗汉柏醇	BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Ferruginol has anti-plasmodial, leishmanicidal, anti-ulcerogenic, cardioprotective, anticancer, anti-oxidative and anti-inflammatory activities, it can induce apoptosis in non-small cell lung cancer (NSCLC) cells.
TN4166	Griffipavixanthone	ERK; Raf; ROS; MEK; Caspase	Apoptosis; Immunology/Inflammation; MAPK; Proteases/Proteasome
	Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. It can inhibit tumor metastasis
TN6062	1,3,9-Trimethyluric acid
	1,3,9-Trimethyluric acid exhibits in vitro cytotoxic activity against breast cancer (MCF-7), human neuroblastoma (SHSY5Y), human non-small cell lung cancer (A549) and human liver cancer (HEPG2) with IC50 value in the range of 1-3 uM. 1,3,9-Trimethyluric a
TN5440	Catechin-7-O-xyloside Catechin 7-O-β-D-xylopyranoside	Others	Others
	Catechin-7-O-xyloside（C7Ox）具有抗癌活性，它通过内质网应激和线粒体功能障碍诱导人非小细胞肺癌H1299细胞凋亡。
TN4774	Physalin A	ERK; BCL; p38 MAPK; NF-κB; Androgen Receptor; ROS; JAK; JNK; STAT; p53; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; Endocrinology/Hormones; Immunology/Inflammation; JAK/STAT signaling; MAPK; NF-κB; Stem Cells
	Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor ex
T11009	Destruxin B	Others	Others
	Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces apoptosis of human non-small cell lung cancer cells through the Bcl-2 family-dependent mitochond
T81132	Soladulcoside A	Others	Others
	Soladulcoside A，一种甾体糖苷及抗肿瘤剂，源自龙葵全株。该化合物可抑制A549细胞，并展示对治疗非小细胞肺癌(NSCLC)等癌症的潜在应用。
T81201	Sartorypyrone B
	Sartorypyrone B为Chevalone C的2β-乙酰氧基衍生物，由海绵源真菌Neosartorya tsunodae(KUFC 9213)的培养物中乙酸乙酯提取得到。该化合物对MCF-7、NCI-H460和A375-C5细胞系展示出较强的生长抑制活性，GI50s值分别为17.8、20.5和25.0 μM，显示其在乳腺癌、非小细胞肺癌和黑色素瘤研究中的应用潜力。
TN7505	Thujopsene NSC 44707	Others	Others
	Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 µg/ml and Ki of 0.8 µM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 µg/ml. It also suppresses antigen-induced β-hexosaminidase release in IgE-se...

天然产物

Cat.No: T2870

Synonym: Vegard,苦参碱,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine

Target: Mitophagy, Ferroptosis, Opioid Receptor, Autophagy

Butyrolactone I

Cat.No: T25192

Synonym: Olomoucin,丁酸内酯I

Target: CDK

Cat.No: T7849

Target: Others

Cat.No: TN5254

Synonym: Erythrinin B,6-Isopentenylgenistein

Target: Antifungal

Cat.No: TN1721

Target: ERK, p38 MAPK, Calcium Channel, NF-κB, ROS

Epimedokoreanin B

Cat.No: TN3972

Target: Apoptosis, Others, Antibacterial

Agatharesinol acetonide

Cat.No: TN3355

Target: Antifection

Cat.No: TN4355

Target: Others

Cat.No: TN1642

Synonym: 铁锈罗汉柏醇

Target: BCL, PARP, Caspase

Griffipavixanthone

Cat.No: TN4166

Target: ERK, Raf, ROS, MEK, Caspase

1,3,9-Trimethyluric acid

Cat.No: TN6062

Catechin-7-O-xyloside

Cat.No: TN5440

Synonym: Catechin 7-O-β-D-xylopyranoside

Target: Others

Cat.No: TN4774

Target: ERK, BCL, p38 MAPK, NF-κB, Androgen Receptor, ROS, JAK, JNK, STAT, p53, Autophagy

Cat.No: T11009

Target: Others

Soladulcoside A

Cat.No: T81132

Target: Others

Sartorypyrone B

Cat.No: T81201

Cat.No: TN7505

Synonym: NSC 44707

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03958	TGF alpha Protein, Human, Recombinant transforming growth factor α,转化生长因子,transforming growth fact...	Human	E. coli
	The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (...
TMPK-01034	SEMA4B Protein, Mouse, Recombinant (His) SEMA4B,SemC,Semaphorin-C,MGC131831,Semaphorin-4B,KIAA1745,SE...	Mouse	HEK293 Cells
	Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling pathway, which subsequently inhibited cell growth through the direct nuclear target of FoxO1, p21. A role of SEMA4B in suppressing NSCLC growth, besides its role in inhibiting cell metastasis, and highlights SEMA4B as a promising therapeutic target for NSCLC.
TMPK-00906	PSCA Protein, Mouse, Recombinant (hFc) UNQ206,PSCA,PRO232	Mouse	HEK293 Cells
	Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein widely expressed in bladder, prostate, and pancreatic cancers. Existing studies have thoroughly recognized the availability of utilizing anti-PSCA CAR-T cells in the treatment of metastatic prostate cancer and non-small-cell lung cancer. PSCA Protein, Mouse, Recomb...
TMPK-00728	PSCA Protein, Human, Recombinant (hFc) UNQ206,PRO232,PSCA	Human	HEK293 Cells
	Gastric cancer is a deadly malignancy and is a prognostically unfavorable entity with restricted therapeutic strategies available. Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein widely expressed in bladder, prostate, and pancreatic cancers. Existing studies have thoroughly recognized the availability of utilizing anti-PSCA CAR-T cells in the treatment of metastatic prostate cancer and non-small-cell lung cancer. PSCA Protein, Human, Recomb...
TMPK-00341	ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated ALCAM,KG-CAM,MEMD,CD166,CD6L	Human	HEK293 Cells
	Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed ...
TMPK-00339	ALCAM Protein, Mouse, Recombinant (His & Avi), Biotinylated CD6L,ALCAM,MEMD,KG-CAM,CD166	Mouse	HEK293 Cells
	Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian...
TMPK-00340	ALCAM Protein, Human, Recombinant (His & Avi), Biotinylated CD166,CD6L,KG-CAM,ALCAM,MEMD	Human	HEK293 Cells
	Brain metastasis (BM) in non-small-cell lung cancer (NSCLC) has a very poor prognosis. Recent studies have demonstrated the importance of cell adhesion molecules in tumor metastasis.Elevated levels of ALCAM expression promote BM formation in NSCLC through increased tumor cell dissemination and interaction with the brain endothelial cells. Therefore, ALCAM could be targeted to reduce the occurrence of BM. ALCAM Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian...
TMPY-04375	Casein Kinase 1 alpha Protein, Human, Recombinant (GST) CKIa,casein kinase 1, alpha 1,casein kinase 1, α1,CK1a,Casei...	Human	Baculovirus Insect Cells
	Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are use...
TMPY-02399	TRF1 Protein, Human, Recombinant (His) TRF,telomeric repeat binding factor (NIMA-interacting) 1,hTR...	Human	Baculovirus Insect Cells
	Telomeric repeat binding factor 1 (TRF1), also known as TERF1, the shelterin complex, which modulates the telomere structures. TRF1 protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Pin2/TRF1 was originally identified as a protein bound to telomeric DNA (TRF1) and as a protein involved in mitotic regulation (Pin2). Pin2/TRF1 negatively regulates telomere length and importantly, its function is tightly regulated during the cell ...
TMPY-04417	DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST) DAPK,death-associated protein kinase 1,ROCO3	Human	Baculovirus Insect Cells
	Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains tenANK repeats, onedeath domain and oneprotein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 g...
TMPY-02796	KIAA0101 Protein, Human, Recombinant (His) L5,NS5ATP9,p15PAF,OEATC1,p15(PAF),OEATC,PAF,p15/PAF,OEATC-1,...	Human	E. coli
	KIAA11, also known as p15(PAF), is a proliferating cell nuclear antigen-associated factor that interacts with proliferating cell nuclear antigen(PCNA). It was initially isolated in a yeast two-hybrid screen for PCNA binding partners and was shown to bind PCNA competitively with the cell cycle regulator p21(WAF). KIAA11 is localized primarily in the nucleus. It shares the conserved PCNA binding motif with several other PCNA binding proteins including CDK inhibitor p21. KIAA11 is involved in cell ...
TMPJ-00281	CADM1 Protein, Mouse, Recombinant (hFc) IgSF4,NECL-2,Nectin-like protein 2,Immunoglobulin superfamil...	Mouse	HEK293 Cells
	Cell adhesion molecule 1(CADM1) is a single-pass type I membrane protein and belongs to the nectin family. It contains 2 Ig-like C2-type (immunoglobulin-like) domains and 1 Ig-like V-type (immunoglobulin-like) domain. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in...

重组蛋白

TGF alpha Protein, Human, Recombinant

Cat.No: TMPY-03958

Species: Human

Expression System: E. coli

SEMA4B Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01034

Species: Mouse

Expression System: HEK293 Cells

PSCA Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00906

Species: Mouse

Expression System: HEK293 Cells

PSCA Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00728

Species: Human

Expression System: HEK293 Cells

ALCAM Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated

Cat.No: TMPK-00341

Species: Human

Expression System: HEK293 Cells

ALCAM Protein, Mouse, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00339

Species: Mouse

Expression System: HEK293 Cells

ALCAM Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00340

Species: Human

Expression System: HEK293 Cells

Casein Kinase 1 alpha Protein, Human, Recombinant (GST)

Cat.No: TMPY-04375

Species: Human

Expression System: Baculovirus Insect Cells

TRF1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02399

Species: Human

Expression System: Baculovirus Insect Cells

DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)

Cat.No: TMPY-04417

Species: Human

Expression System: Baculovirus Insect Cells

KIAA0101 Protein, Human, Recombinant (His)

Cat.No: TMPY-02796

Species: Human

Expression System: E. coli

CADM1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00281

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T11067	VX-984 M9831	DNA-PK	DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	VX-984 (M9831) 是一种可口服的、具有选择性的的、可透过血脑屏障的 DNA-PK 抑制剂。VX-984 对非同源性末端 NHEJ 的接合具有抑制作用，可作用于 DSBs 使 DNA 双链断裂。VX-984常见于对胶质母细胞瘤 (GBM) 和非小细胞肺癌 (NSC-LC) 的研究。
TMIH-0413	Osimertinib-d6
	Osimertinib-d6 是 Osimertinib 的氘代化合物。Osimertinib 的 CAS 号为 1421373-65-0。Osimtinib 是一种小分子酪氨酸激酶受体抑制剂和抗肿瘤剂，用于治疗选定形式的晚期非小细胞肺癌，其有效抑制 L858R 和 L858R/T790M EGFR，IC50 为 12 和 1 nM。
T72818	Dosimertinib-d3
	Dosimertinib-d3是一种有效的口服活性EGFR 抑制剂。Dosimertinib-d3降低 p-EGFR 和 p-ERK 蛋白水平的表达。Dosimertinib-d3显示出抗增殖和抗肿瘤活性。Dosimertinib-d3具有非小细胞肺癌 (NSCLC) 研究的潜力。
T35915	Erlotinib-13C6 Erlotinib-13C6
	Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]...

同位素标记化合物

Cat.No: T11067

Synonym: M9831

Target: DNA-PK

Cat.No: TMIH-0413

Dosimertinib-d3

Cat.No: T72818

Cat.No: T35915

Synonym: Erlotinib-13C6

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼