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Cat. No. | Product Name | ||
---|---|---|---|
L1710 | 抗COVID-19化合物库 | 1133 compounds | |
1133 种对SARS-CoV-2有抑制作用或潜在抑制作用的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9614 |
MERS-CoV-IN-1
|
SARS-CoV | Microbiology/Virology |
MERS-CoV-IN-1 对冠状病毒的活性具有优异的抑制作用,可用作预防冠状病毒引起疾病的药物组合物。 | |||
T8419 |
XP-59
|
SARS-CoV | Microbiology/Virology |
XP-59 是一种 SARS-CoV Mpro 抑制剂,其 Ki 值为 0.1 nM。 | |||
T40276 |
GS-621763
|
SARS-CoV | Microbiology/Virology |
GS-621763 是具有口服活性的 GS-441524 前药,在小鼠体内具有抗SARS-CoV-2病毒活性。 | |||
T7872 |
Monolaurin
|
Others | Others |
Monolaurin 是椰子油中的一种表面活性剂和乳化剂。它抑制葡萄球菌、链球菌、加德纳菌、念珠菌和嗜血杆菌的生长,并减少促炎细胞因子的产生。 | |||
T9109 |
SSAA09E2
|
RAAS; SARS-CoV | Endocrinology/Hormones; Microbiology/Virology |
SSAA09E2 是一种新型的SARS-CoV 复制抑制剂,通过阻断SARS-S 与SARS-CoV 受体血管紧张素转换酶-2 的早期相互作用发挥作用。 | |||
T9458 |
PF-00835231
|
SARS-CoV | Microbiology/Virology |
PF-00835231 是一种 CoV-2 半胱氨酸 3C 样蛋白酶抑制剂,对 SARS CoV-2 和 SARS CoV-1 3CLpro 的 IC50 分别为 0.27 nM 和 4 nM。它用于抗 SARS-CoV-2/COVID-19 的研究。 | |||
T9672 |
GRL-0496
|
SARS-CoV | Microbiology/Virology |
GRL-0496 是氯吡啶酯衍生物,是有效的 SARS-CoV 3CLpro 抑制剂,IC50为 30 nM。GRL-0496显示出抗 SARS-CoV 病毒活性,EC50为 6.9 μM。 | |||
T9351 |
Nirmatrelvir
|
SARS-CoV | Microbiology/Virology |
Nirmatrelvir (PF-07321332) 是一种 SARS-CoV 3CLPRO 抑制剂,一种胰蛋白酶样蛋白酶抑制剂,具有有效性和口服活性。Nirmatrelvir 对 SARS-CoV-2 病毒有针对性,可研究 COVID-19。 | |||
T21727 |
Ivermectin B1a
|
SARS-CoV; Parasite | Microbiology/Virology |
Ivermectin B1a 是 Avermectin B1a 的一种衍生物,是 Ivermectin 的主要成分。Ivermectin 是广谱的抗寄生虫剂。Ivermectin 也是抗 SARS-CoV-2/COVID-19 的候选药物。 | |||
T11464 |
GRL0617
|
SARS-CoV; DUB | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Ubiquitination |
GRL0617 是一种选择性和竞争性的 SARS-CoVPLpro 和去泛素酶非共价抑制剂,其 IC50值为 0.6 μM,Ki 值为 0.49 μM. | |||
T9618 |
HeE1-2Tyr
|
SARS-CoV | Microbiology/Virology |
HeE1-2Tyr 是 一种pyridobenzothiazole,抑制黄病毒 RNA 依赖性 RNA 聚合酶。HeE1-2Tyr 在体外对Dengue, West Nile 和 SARS-CoV-2 RdRps 有显著的抑制活性(IC50为 27.6 µM) 。 | |||
T8371 |
ML188
|
Virus Protease; SARS-CoV | Microbiology/Virology |
ML188是一种选择性非共价 SARS-CoV3CLpro 抑制剂,具有抗病毒活性,IC50为 1.5 μM。 | |||
T6738 |
Z-FA-FMK
|
SARS-CoV; Cysteine Protease | Microbiology/Virology; Proteases/Proteasome |
Z-FA-FMK 是一种广谱的卤代甲基酮抑制剂,可抑制冠状病毒蛋白酶3CL,Ki 为 25.7 μM。它可以不可逆地抑制半胱氨酸蛋白酶,也可以抑制效应半胱天冬酶。 | |||
T5126 |
Glecaprevir
ABT-493 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Glecaprevir (ABT-493) 是一种新型的 HCV NS3/4A 蛋白酶抑制剂,其 IC50值在 3.5 和 11.3 nM 之间。它也是 SARS-CoV 3CLpro 的抑制剂,IC50为 4.09 μM。 | |||
T60014 |
SHEN26
|
Antiviral | Immunology/Inflammation |
SHEN26 具有抗病毒活性,可用于治疗病毒感染的研究。 | |||
T22323 |
Enoxaparin sodium
|
Thrombin | Proteases/Proteasome |
Enoxaparin sodium 是一种低分子量肝素 (LMWH),已获得美国 FDA 批准,可用于医疗管理的 ST 段心肌梗死 (STEMI) 或 STEMI 及随后的经皮冠状动脉介入治疗 (PCI) 患者。它与抗凝血酶结合并增强其作用,并抑制凝血因子 XIa、IXa、Xa 和 IIa(凝血酶),从而防止血栓形成。 | |||
T1303 |
Auranofin
醋硫葡金,SKF-39162 |
Others; SARS-CoV; Antibacterial | Microbiology/Virology; Others |
Auranofin (SKF-39162) 是一种硫氧还蛋白还原酶 TrxR 抑制剂 (IC50=0.2 μM)。Auranofin 是一种抗风湿剂,用于治疗类风湿性关节炎,改善关节炎症状。Auranofin 也具有对 SARS-CoV21 的抗病毒活性。 | |||
T1307 |
Carmofur
HCFU,卡莫氟 |
Nucleoside Antimetabolite/Analog; Virus Protease; SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Carmofur (HCFU) 是 5-氟尿嘧啶的衍生物,是一种抗肿瘤药物。它是一种酸性神经酰胺酶抑制剂,用于治疗乳腺癌和结直肠癌。它抑制 SARS-CoV-2主要蛋白酶,还抑制 Vero E6 细胞 SARS-CoV-2,EC50为 24.3 μM。 | |||
T3334 |
Velpatasvir
GS-5816,维帕他韦 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Velpatasvir (GS-5816) 是一种的 HCV NS5A 抑制剂。它也是 SARS-CoV 3CLpro 的抑制剂,IC50为 2.16 μM。 | |||
T4547 |
Grazoprevir
MK-5172 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Grazoprevir (MK-5172) 是一种丙型肝炎病毒 NS3/4a 蛋白酶的选择性抑制剂,具有跨基因型和耐药变体的广泛活性,对 gt1b、gt1a、gt2a、gt2b 和 gt3a 的Ki 分别为 0.01 nM、0.01 nM、0.08 nM、0.15 nM 和 0.90 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。 | |||
T9716 |
Ensitrelvir
S-217622 |
SARS-CoV | Microbiology/Virology |
Ensitrelvir (S-217622) 是首个口服有效的、非共价的、非肽的SARS-CoV-2 3CL 蛋白酶抑制剂,IC50为13 nM。 | |||
T7903 |
Saquinavir
Ro 31-8959,沙奎那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Saquinavir (Ro 31-8959) 是一种 HIV 蛋白酶抑制剂,可研究逆转录病毒。它也是 SARS-CoV 3CLpro 抑制剂,IC50为 1.36 μM。 | |||
T0211 |
Azelastine
Azelastina,Astelin,Azelastinum,氮卓斯汀 |
SARS-CoV; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Azelastine (Azelastinum) 是一种选择性组胺 1 拮抗剂,可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。 | |||
T6040 |
Aloxistatin
E64d,Loxistatin,阿洛司他丁,E64c ethyl ester |
SARS-CoV; Cysteine Protease | Microbiology/Virology; Proteases/Proteasome |
Aloxistatin (E64d) 是一种不可逆的、可透过膜的溶酶体和细胞溶质半胱氨酸蛋白酶抑制剂,能够抑制完整血小板中的钙蛋白酶活性。它是一种半胱氨酸蛋白酶抑制剂,具有血小板聚集抑制活性。 | |||
T8676 |
FOY 251
|
Others; Serine/threonin kinase; SARS-CoV | Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Others |
FOY 251 是一种蛋白酶抑制剂,是具有抗蛋白水解活性的 Camostate 代谢物,能抑制 SARS-CoV-2 的感染。 | |||
T6200 |
Ledipasvir
GS-5885,雷迪帕韦 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Ledipasvir (GS-5885) 是一种丙型肝炎病毒 NS5A 抑制剂。它也是 P-糖蛋白抑制剂和乳腺癌抗性蛋白抑制剂。 | |||
T9341 |
Bemnifosbuvir
AT-511 |
Others; HCV Protease; SARS-CoV | Microbiology/Virology; Others; Proteases/Proteasome |
Bemnifosbuvir (AT-511) 是一种口服活性抑制剂,抑制 HCV 病毒复制,具有全基因型抗病毒活性。它有效抑制 SARS-CoV-2 (COVID-19)感染 (EC90=0.47 μM)。 | |||
T12502 |
PLpro inhibitor
5-(乙酰氨基)-2-甲基-N-[(1R)-1-(1-萘基)乙基]苯甲酰胺 |
SARS-CoV | Microbiology/Virology |
PLpro inhibitor 是一种木瓜蛋白酶抑制剂,IC50为 2.6 µM,能抑制 SARS-CoV-2 PLpro。 | |||
T4474 |
Asunaprevir
BMS-650032,阿那匹韦 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Asunaprevir (BMS-650032) 是一种有口服活性的 HCV NS3 蛋白酶抑制剂,IC50值为 0.2 nM-3.5 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。 | |||
T9331 |
Bemnifosbuvir hemisulfate
AT-527 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Bemnifosbuvir hemisulfate (AT-527) 是一种 HCV 病毒复制抑制剂。 | |||
T7766 |
Remdesivir
瑞德西韦,GS-5734 |
SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Remdesivir (GS-5734) 是一种核苷类似物,一种广谱的抗病毒化合物,通过抑制病毒的 RNA 依赖性 RNA 聚合酶发挥活性。Remdesivir 对埃博拉病毒、SARS 病毒、MERS病毒等均有活性,对 COVID-19 有潜在治疗价值。 | |||
T9066 |
Merafloxacin
CI 934 |
SARS-CoV | Microbiology/Virology |
Merafloxacin (CI 934) 是一种氟喹诺酮类抗菌药物,也被确定为 SARS-CoV-2 的 1 PRF 抑制剂。它对革兰氏阳性菌和革兰氏阴性菌具有体外活性。 | |||
T2486 |
IOWH-032
IOWH032,IOWH 032 |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
IOWH-032 (IOWH032) 是一种合成 CFTR 抑制剂,可用于研究治疗霍乱、腹泻和分泌性腹泻,在T84和CHO-CFTR 细胞实验中IC50为1.01 uM。 | |||
T1623 |
Lopinavir
ABT-378,洛匹那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Lopinavir (ABT-378) 是一种选择性肽模拟 HIV-1 蛋白酶的高效抑制剂。它通过阻止 HIV-1 的成熟而起作用,从而阻断其感染性。它也是 SARS-CoV 3CLpro 的抑制剂。 | |||
T22394 |
Paritaprevir
ABT450,ABT-450,帕利普韦,Veruprevir |
HCV Protease | Microbiology/Virology; Proteases/Proteasome |
Paritaprevir (ABT450) 是一种非结构蛋白 3/4A 蛋白酶抑制剂,对 HCV 1a 和 HCV 1b 的 EC50 值分别为 1 和 0.21 nM。它也是SARS-CoV 3CLpro 的抑制剂,IC50为 1.31 μM。 | |||
T1817 |
GNF-2
GNF2 |
SARS-CoV; Bcr-Abl | Angiogenesis; Cytoskeletal Signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors |
GNF-2 是一种高选择性的非 ATP 竞争性 Bcr-Abl 抑制剂。 它抑制 Ba/F3.p210 增殖,IC50为 138 nM。 | |||
T0211L |
Azelastine hydrochloride
Optivar,Azelastine HCl,Allergodil,盐酸氮卓斯汀,Astelin |
SARS-CoV; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience |
Azelastine hydrochloride (Astelin) 是一种选择性组胺 1拮抗剂,可研究过敏性鼻炎、哮喘、糖尿病高脂血症和 SARS-CoV-2 。 | |||
T8688 |
(Rac)-X77
CPD77,MUN91789 |
SARS-CoV | Microbiology/Virology |
(Rac)-X77 (MUN91789) 是一种 SARS-CoV-2 主要蛋白酶抑制剂。 | |||
T0828 |
Bromhexine hydrochloride
Bromhexine HCl,Auxit,盐酸溴己新,Bisolvon |
SARS-CoV; HIV Protease; Autophagy | Autophagy; Microbiology/Virology; Proteases/Proteasome |
Bromhexine hydrochloride (Bisolvon) 是TMPRSS2蛋白酶的一种特异性有效抑制剂,IC50为 0.75 μM。它可预防和控制SARS-CoV-2感染。它是一种粘液溶解剂,用于治疗与粘稠或过多粘液相关的呼吸系统疾病。 | |||
T6573 |
E 64c
阿洛司他丁酸,NSC 694279,EP 475,Loxistatin Acid |
SARS-CoV; Cysteine Protease | Microbiology/Virology; Proteases/Proteasome |
E 64c (EP 475) 是一种不可逆且可透过膜的半胱氨酸蛋白酶抑制剂,是 E-64 的衍生物。它也是钙离子激活中性蛋白酶抑制剂和组织蛋白酶 C 弱不可逆抑制剂,可抑制 MERS-CoV。 | |||
T7222 |
GS-441524
GS 441524 triphosphate |
Others; SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others |
GS-441524 是 Remdesivir 的主要活性代谢物,活性更优于 Remdesivir ,治疗患有自然发生的猫传染性腹膜炎的猫。 | |||
T9287 |
Hydroxychloroquine
2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol,羟氯喹 |
SARS-CoV; TLR; Parasite; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology |
Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) 是一种合成抗疟疾剂,有效抑制SARS-CoV-2感染,也抑制 Toll 样受体 7/9 信号传导。 | |||
T4988 |
Boceprevir
SCH 503034,EBP 520,波普瑞韦 |
HCV Protease; SARS-CoV | Microbiology/Virology; Proteases/Proteasome |
Boceprevir (SCH 503034) 是一种口服有效的选择性 HCV NS3 蛋白酶抑制剂。在酶试验中的 Ki 为 14 nM,在基于细胞的复制子试验中 EC90 为 350 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。 | |||
T0860 |
Mefloquine hydrochloride
Mefloquin hydrochloride,Mefloquine HCl,盐酸甲氟喹 |
Potassium Channel; SARS-CoV; Reactive Oxygen Species; Parasite; Autophagy | Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB |
Mefloquine hydrochloride (Mefloquin hydrochloride) 是喹啉抗疟药,是抗 SARS-CoV-2进入抑制剂,可研究疟疾、系统性红斑狼疮和癌症。它也是 K+通道(KvQT1/minK) 拮抗剂,IC50约为 1 μM。 | |||
T2392 |
Nafamostat mesylate
甲磺酸萘莫司他,FUT-175 |
Apoptosis; Serine/threonin kinase; SARS-CoV; Serine Protease | Apoptosis; Cell Cycle/Checkpoint; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Nafamostat mesylate (FUT-175) 是一种广谱丝氨酸蛋白酶抑制剂,血管舒缓素抑制剂,能抑制血液凝固。它通过降低颗粒酶活性和 CTL 细胞溶解抑制T 细胞自身反应活性,可抑制SARS-CoV-2 的激活。它还是潜在的补体抑制剂。 | |||
T0951 |
Hydroxychloroquine sulfate
Acidum iopanoicum,硫酸羟基氯喹,硫酸羟氯喹,HCQ sulfate |
DNA; SARS-CoV; TLR; Parasite; Autophagy | Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Microbiology/Virology |
Hydroxychloroquine sulfate (Acidum iopanoicum) 抑制疟原虫血红素聚合酶。它还可抑制 Toll 样受体 7/9 信号传导和 SARS-CoV-2 感染。 | |||
T5013 |
Brequinar
Bipenquinate,NSC 368390,DUP785,布喹那 |
Virus Protease; Dehydrogenase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Brequinar (NSC-368390) 是二氢乳清酸脱氢酶的一种强效抑制剂,对广谱病毒具有强效活性。 | |||
T2391 |
Camostat mesylate
FOY-S980,甲磺酸卡莫司他,FOY305,Camostat mesilate |
Serine/threonin kinase; SARS-CoV; Sodium Channel | Cell Cycle/Checkpoint; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Camostat mesylate (FOY-S980) 是口服活性合成的丝氨酸蛋白酶抑制剂,用于慢性胰腺炎。它是TMPRSS2的抑制剂,对SARS-CoV-2具有抗病毒活性。它抑制前列腺素、胰蛋白酶和苦参多糖的活性。 | |||
T0104 |
Umifenovir hydrochloride
盐酸阿比朵尔,Arbidol hydrochloride,Arbidol HCl,盐酸阿比多尔 |
SARS-CoV; Influenza Virus | Microbiology/Virology |
Umifenovir hydrochloride (Arbidol HCl) 是一种口服有效的广谱抗病毒药物,对多种包膜和非包膜病毒均有活性。它被用作抗流感病毒剂,可通过阻断病毒与宿主细胞膜的融合来抑制包膜病毒的细胞侵袭。它是一种 SARS-CoV-2 抑制剂,具有抗炎活性。 | |||
T6388 |
Amprenavir
141W94,安普那韦,Prozei,KVX-478,VX-478,安瑞那韦 |
SARS-CoV; HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Amprenavir (KVX-478) 是一种 HIV 蛋白酶抑制剂,Ki 为0.6 nM。它也是 SARS-CoV 3CLpro 抑制剂,IC50为 1.09 μM。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN3651 |
Cichoriin
|
Others | Others |
Cichoriin 对SARS-CoV-2有明显活性,是治疗重症COVID-19的潜在候选物质。 | |||
T40660 |
Kansuinine B
|
IL Receptor; SARS-CoV | Immunology/Inflammation; Microbiology/Virology |
Kansuinine B 抑制由 IL-6 诱导的 Stat3 活化。 Kansuinine B 具有抗病毒活性,可用于 COVID-19 研究。 | |||
T3S1447 |
Arteannuin B
|
SARS-CoV; Ferroptosis | Apoptosis; Microbiology/Virology |
Arteannuin B 与青蒿素共同存在,有强效抗疟活性,具有抗 SARS-CoV-2 的活性,EC50为 10.28 μM。 | |||
TQ0302 |
Thapsigargin
毒胡萝卜素 |
Apoptosis; SARS-CoV; Calcium Channel | Apoptosis; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology |
Thapsigargin 属于天然产物,是一种肌/内质网 Ca2+ ATP 酶 (SERCA) 的抑制剂,也是一种内质网应激诱导剂。Thapsigargin 通过阻断细胞将钙泵入肌浆和内质网的能力来提高胞浆钙浓度。 | |||
T2869 |
Emodin
Frangula emodin,大黄素 |
SARS-CoV; Casein Kinase; Autophagy | Autophagy; Metabolism; Microbiology/Virology; Stem Cells |
Emodin (Frangula emodin) 是蒽醌衍生物,有抗SARS-CoV 作用。它阻断 SARS 冠状病毒刺突蛋白和血管紧张素转化酶 2 的相互作用。它抑制酪蛋白激酶 2 ,具有抗炎和抗癌作用。它可改善饮食诱导的肥胖小鼠的代谢紊乱。 | |||
TQ0180 |
Chebulagic acid
|
SARS-CoV; Influenza Virus; Lipoxygenase; COX | Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience |
Chebulagic acid 是从 Terminalia chebula Retz 中分离出来的一种 COX-LOX 双重抑制剂,有抗炎和抗感染作用。它抑制 SARS-CoV-2病毒的复制,EC50值为 9.76 μM。它还是 M2(S31N)抑制剂和抗流感病毒剂。 | |||
T1134 |
Clofoctol
叔辛酚氯,氯福克酚 |
Antibacterial; Antibiotic | Microbiology/Virology |
Clofoctol 是一种抗生素,,可研究革兰氏阳性菌感染。它仅对革兰氏阳性菌起作用, 可渗透入人类肺组织。 | |||
T9715 |
Aplidine
|
SARS-CoV; DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Aplidine 是有效的eEF1A2(KD=80 nM) 靶向的抗癌药物。Aplidine 具有抗病毒活性,抑制SARS-CoV-2的 IC90为 0.88 nM。Aplidine 在多发性骨髓瘤,晚期癌症及 COVID-19 领域有研究的价值。 | |||
T6670 |
Silymarin
Silybin B,水飞蓟素 |
SARS-CoV | Microbiology/Virology |
Silymarin (Silybin B) 是一种多酚类黄酮,是从水飞蓟或水飞蓟的种子中提取的一种 SARS-CoV-2 主蛋白酶抑制剂。它可降低肿瘤细胞的增殖,血管生成以及胰岛素抵抗,用于预防和治疗肝脏疾病,有潜力研究 COVID-19 。 | |||
T2898 |
Andrographolide
Andrographis,穿心莲内酯 |
SARS-CoV; Influenza Virus; NF-κB; Autophagy | Autophagy; Microbiology/Virology; NF-κB |
Andrographolide (Andrographis) 是 NF-κB 的不可逆拮抗剂,具有抗病毒、抗炎和抗血小板聚集活性和潜在的抗肿瘤作用。 | |||
T3921 |
Punicalagin
安石榴甙,安石榴苷 |
SARS-CoV; HBV | Microbiology/Virology |
Punicalagin 是一种在石榴中发现的主要鞣花单宁,是可逆且非竞争性的 3CLpro 抑制剂。Punicalagin 具有抗氧化、抗炎和抗肿瘤活性。 | |||
T8689 |
Chloroquine
CQ,氯喹 |
SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Chloroquine 是一种 Toll 样受体抑制剂,可以抑制自噬。Chloroquine 具有抗疟疾和抗炎活性,广泛用于治疗疟疾和类风湿性关节炎。Chloroquine 还具有抗 SARS-CoV-2 (COVID-19) 活性、抗 HIV-1 活性。 | |||
T3319 |
Scutellarein
野黄芩素,4',5,6,7-Tetrahydroxyflavone,6-Hydroxyapigenin |
SARS-CoV; Src; Autophagy | Angiogenesis; Autophagy; Microbiology/Virology; Tyrosine Kinase/Adaptors |
Scutellarein (6-Hydroxyapigenin) 是一种天然黄酮,具有抗炎功效。 | |||
T0131 |
Cepharanthine
NSC-623442,千金藤碱,千金藤素 |
Apoptosis; TNF; HIV Protease; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome |
Cepharanthine (NSC-623442) 是从Stephania cepharanthaHayata 中提取的一种生物碱,具有抗炎、抗氧化作用。它可抑制肿瘤坏死因子 (TNF)-α 介导的 NFκB 刺激、质膜脂质过氧化和血小板聚集,并抑制细胞因子的产生。 | |||
T3S0136 |
4'-O-Methylbavachalcone
O-Methylbroussochalcone B,4'-O-甲基补骨脂查尔酮 |
SARS-CoV | Microbiology/Virology |
4'-O-Methylbavachalcone (O-Methylbroussochalcone B) 是从补骨脂中分离得到的一种查尔酮,可抑制严重急性呼吸综合征冠状病毒木瓜样蛋白酶的活性,IC50值为 10.1 μM。 | |||
T3374 |
Dihydrotanshinone I
DHTS,15,16-dihydrotanshinone I,二氢丹参酮I,二氢丹参酮 I |
SARS-CoV; ROS | Immunology/Inflammation; Microbiology/Virology |
Dihydrotanshinone I (DHTS) 是从丹参中分离到的一种天然产物,可抑制 MERS-CoV,可研究心血管疾病。 | |||
T1131 |
Ivermectin
MK-933,伊维菌素 |
Mitophagy; GluCls; P2X Receptor; SARS-CoV; HIV Protease; Antibiotic; Parasite; Autophagy; HSV | Autophagy; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Ivermectin (MK-933) 是谷氨酸门控氯离子通道激活剂,具有抗寄生虫活性。它特异性抑制Impα/β1 介导的核导入,还抑制牛疱疹病毒 1 复制并抑制BoHV-1DNA 聚合酶的核输入。它具有很强的抗病毒活性。它也是P2X4和 α7nAChRs 的正异构效应物。 | |||
T7991 |
2-Hydroxycinnamic acid
邻羟基肉桂酸(邻香豆酸),(E)-3-(2-羟基苯基)丙烯酸 |
Others; SARS-CoV; HIV Protease | Microbiology/Virology; Others; Proteases/Proteasome |
2-Hydroxycinnamic acid 是从肉桂的甲醇提取物中分离出的一种天然产物,具有光氧化活性。它对HIV/SARS-CoV S 假病毒的感染具有抑制作用,IC50为 0.3 mM。 | |||
T1188 |
Mizoribine
Bredinin,NSC 289637,咪唑立宾,HE 69 |
HCV Protease; SARS-CoV; Tyrosinase | Microbiology/Virology; Proteases/Proteasome |
Mizoribine (NSC-289637) 是一种免疫抑制剂,抑制HCVRNA 复制,有抗 HCV 活性,IC50约为 100 μM。它抑制SARS-CoV 复制,对 SARS-CoV Frankfurt-1 和 SARS-CoV HKU39849 的 IC50分别为 3.5 μg/mL 和 16 μg/mL。 | |||
T0194 |
Chloroquine phosphate
Chloroquine diphosphate,Aralen phosphate,磷酸氯喹,Chingamin phosphate |
SARS-CoV; TLR; HIV Protease; Antibiotic; Parasite; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Chloroquine phosphate (Aralen phosphate) 是广泛用于疟疾和类风湿性关节炎的抗疟疾和抗炎剂。它是autophagy 和toll-like receptors 抑制剂,有效抑制SARS-CoV-2(COVID-19) 感染 (EC50=1.13 μM)。 | |||
T7060 |
Amantadine
1-Aminoadamantane,1-金刚烷胺,金刚烷胺,1-Adamantanamine,1-Adamantylamine |
Others | Others |
Amantadine (1-Aminoadamantane) 是抗病毒药物,也是是 NMDA 型谷氨酸受体的弱拮抗剂,能促进高多巴胺的释放,并阻断多巴胺的再摄取。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02870 |
SARS-CoV Nucleocapsid Protein (His)
coronavirus Nucleocapsid Protein, SARS, |
SARS | Baculovirus Insect Cells |
SARS-CoV Nucleocapsid Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 47.5 kDa and the accession number is Q6S8E1. | |||
TMPY-06176 |
SARS-CoV (Isolate Tor2) Spike S1+S2 Protein (S577A, His), Biotinylated
nove,ncov spike Protein, SARS,coronavirus ... |
SARS | Baculovirus Insect Cells |
SARS-CoV (Isolate Tor2) Spike S1+S2 Protein (S577A, His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 132.58 kDa and the accession number is NP_828851.1. | |||
TMPY-06204 |
SARS-CoV (Isolate Tor2) Spike RBD Protein (His & Avi), Biotinylated
ncov spike Protein, SARS,ncov RBD Protein, SARS... |
SARS | HEK293 Cells |
SARS-CoV (Isolate Tor2) Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.4 kDa and the accession number is NP_828851.1. | |||
TMPY-05817 |
SARS-CoV Spike/RBD Protein (His), Biotinylated
ncov spike Protein, SARS,novel coronavirus... |
SARS | Baculovirus Insect Cells |
SARS-CoV Spike/RBD Protein (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is Q5DIC5. | |||
TMPY-05718 |
SARS-CoV (Isolate Tor2) Spike S1+S2 ECD Protein (S577A, His)
ncov s2 Protein, SARS,nove,coronavirus spi... |
SARS | Baculovirus Insect Cells |
SARS-CoV (Isolate Tor2) Spike S1+S2 ECD Protein (S577A, His) is expressed in Baculovirus insect cells. The predicted molecular weight is 132.58 kDa and the accession number is NP_828851.1. | |||
TMPY-05702 |
SARS-CoV Spike/S1 Protein (mFc)
coronavirus spike Protein, SARS,corona... |
SARS | HEK293 Cells |
SARS-CoV Spike/S1 Protein (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 99.40 kDa and the accession number is Q5DIC5. | |||
TMPY-06372 |
SARS-CoV Spike RBD Protein (mFc), Biotinylated
ncov spike Protein, SARS,cov spike Protein, SAR... |
SARS | HEK293 Cells |
SARS-CoV Spike RBD Protein (mFc), Biotinylated is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 51.49 kDa and the accession number is AAX16192.1. | |||
TMPY-05722 |
SARS-CoV Spike S2 Protein (His)
coronavirus spike Protein, SARS,ncov s2 Pr... |
SARS | Baculovirus Insect Cells |
SARS-CoV Spike S2 Protein (His) is expressed in Baculovirus insect cells. The predicted molecular weight is 59.65 kDa and the accession number is NP_828851.1. | |||
TMPY-04177 |
SARS-CoV Spike/RBD Protein (rFc)
cov spike Protein, SARS,ncov s1 Protein, SARS |
SARS | Baculovirus Insect Cells |
SARS-CoV Spike/RBD Protein (rFc) is expressed in Baculovirus insect cells with rFc tag. The predicted molecular weight is 50.2 kDa and the accession number is Q5DIC5. | |||
TMPY-03224 |
SARS-CoV Spike/RBD Protein (His)
ncov s2 Protein, SARS,cov spike Protein, SARS |
SARS | Baculovirus Insect Cells |
SARS-CoV Spike/RBD Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is Q5DIC5. | |||
TMPY-05701 |
SARS-CoV Spike/RBD Protein (mFc)
ncov spike Protein, SARS,nove,ncov s2 Protein, ... |
SARS | HEK293 Cells |
SARS-CoV Spike/RBD Protein (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 51.40 kDa and the accession number is Q5DIC5. | |||
TMPY-05699 |
SARS-CoV Spike/S1 Protein (His), Biotinylated
ncov s1 Protein, SARS,coronavirus s2 Prote... |
SARS | Baculovirus Insect Cells |
SARS-CoV Spike/S1 Protein (His), Biotinylated is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 74.4 kDa and the accession number is Q5DIC5. | |||
TMPY-03988 |
SARS-CoV Spike/S1 Protein (His)
ncov RBD Protein, SARS,nove,ncov s1 Protein, SA... |
SARS | Baculovirus Insect Cells |
SARS-CoV Spike/S1 Protein (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 74.4 kDa and the accession number is Q5DIC5. | |||
TMPJ-01449 |
3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant
M Proteinase,3C-like Proteinase,3CL Proteinase |
SARS-CoV-2 | E. coli |
The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant is expressed in E. coli expression system. The predicted molec... | |||
TMPK-00705 |
MASP2 Protein, Human, Recombinant (His)
MAP19,sMap,MASP-2,MASP1P1 |
Human | E. coli |
The pathogenesis of severe acute respiratory disease syndrome (SARS) is not fully understood. One case-control study has reported an association between susceptibility to SARS and mannan-binding lectin (MBL) in China. As the downstream protein of MBL, variants of the MBL-associated serine protease-2 (MASP2) gene may be associated with SARS coronavirus (SARS-CoV) infection in the same population. | |||
TMPJ-01448 |
3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His)
M Proteinase,3CL Proteinase |
2019-nCoV | E. coli |
The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex. It functions as a cysteine protease engaging in the proteolytic cleavage of the viral precursor polyprotein to a series of functional proteins required for coronavirus replication and is considered as an appealing target for designing anti-SARS agents. 3CLpro/3C-like Protease Protein, SARS-CoV-2, Recombinant (His) is expressed in E. coli expression system with N-6xHis t... | |||
TMPY-06416 |
SARS-CoV-2 NSP8 Protein
|
SARS-CoV-2 | E. coli |
NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein is expressed in E. coli expression system. The predicted molecular weight is 22.04 kDa and the accession number is... | |||
TMPY-05749 |
SARS-CoV-2 NSP8 Protein (Avi)
|
SARS-CoV-2 | E. coli |
NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein (Avi) is expressed in E. coli expression system. The predicted molecular weight is 24.17 kDa and the accession num... | |||
TMPY-05752 |
SARS-CoV-2 3CLpro/3C-like protease Protein (His)
|
SARS-CoV-2 | Baculovirus Insect Cells |
3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication and Coronavirus virion production, such as an RNA-dependent RNA polymerase, a helicase, ribonucleases and 3CLpro itself, from two types of polyproteins (pp1a and pp1ab). SARS-CoV 3CLpro exists as a homodimer and each protomer has an active site. SARS-CoV-2 3CLpro/3C-like protease P... | |||
TMPY-05727 |
SARS-CoV-2 3CLpro/3C-like protease Protein (His & Avi)
|
SARS-CoV-2 | E. coli |
3C-like protease (3CLpro) is the main protease of Humann Coronavirus. 3C-like protease (3CLpro) is a key enzyme, as it cleaves several sites to produce non-structural proteins that are essential for genome replication and Coronavirus virion production, such as an RNA-dependent RNA polymerase, a helicase, ribonucleases and 3CLpro itself, from two types of polyproteins (pp1a and pp1ab). SARS-CoV 3CLpro exists as a homodimer and each protomer has an active site. SARS-CoV-2 3CLpro/3C-like protease P... | |||
TMPH-02236 |
TMPRSS2 Protein, Human, Recombinant (E. coli, His)
Transmembrane protease serine 2,TMPRSS2,Serine protease 10 |
Human | E. coli |
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.... | |||
TMPH-02237 |
TMPRSS2 Protein, Human, Recombinant (His & Myc)
Serine protease 10,Transmembrane protease serine 2,TMPRSS2 |
Human | HEK293 Cells |
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.... | |||
TMPY-05693 |
SARS-CoV-2 Methyltransferase/ME Protein (His)
|
SARS-CoV-2 | E. coli |
Coronavirus encodes the 2’-O-MTase (2'O Methyltransferase) that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate immunity during viral infection. Nonstructural protein 16 (NSP16) / viral 2'O-methyltransferase (2'O-MTase) is highly conserved. The conserved 2'O-MTase activity is important for CoV pathogenesis and NSP16 is a conserved universal target for rapid live attenuated vaccine design ... | |||
TMPK-01335 |
3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant
M Proteinase,Mpro,3CL Protease,3CL-Mpro |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (E166V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.80 kDa and the accession number is YP_009725301.1. | |||
TMPK-01343 |
3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant
3CL-Mpro,M Proteinase,Mpro,3CL Protease |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (A191T), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1. | |||
TMPH-02239 |
TMPRSS4 Protein, Human, Recombinant (His & Myc)
Channel-activating protease 2,TMPRSS4,Transmembrane protease... |
Human | E. coli |
Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC.; (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. TMPRSS4 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10... | |||
TMPK-01342 |
3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant
Mpro,3CL-Mpro,3CL Protease,M Proteinase |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (A191V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.8kDa and the accession number is YP_009725301.1. | |||
TMPK-01347 |
3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant
3CL-Mpro,3CL Protease,M Proteinase,Mpro |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (E166A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.4kDa and the accession number is YP_009725301.1. | |||
TMPK-01336 |
3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant
3CL-Mpro,3CL Protease,M Proteinase,Mpro |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F, E166V), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.80 kDa and the accession number is YP_009725301.1. | |||
TMPK-01346 |
3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant
3CL-Mpro,Mpro,M Proteinase,3CL Protease |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8kDa and the accession number is YP_009725301.1. | |||
TMPK-01339 |
3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant
3CL-Mpro,M Proteinase,3CL Protease,Mpro |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (S144A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.78 kDa and the accession number is YP_009725301.1. | |||
TMPK-01337 |
3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant
Mpro,3CL-Mpro,3CL Protease,M Proteinase |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (Q189K), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.79 kDa and the accession number is YP_009725301.1. | |||
TMPK-01340 |
3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant
3CL-Mpro,3CL Protease,M Proteinase,Mpro |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (F140A), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.72 kDa and the accession number is YP_009725301.1. | |||
TMPK-01338 |
3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant
M Proteinase,3CL-Mpro,Mpro,3CL Protease |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (H172Y), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.82 kDa and the accession number is YP_009725301.1. | |||
TMPK-01341 |
3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant
3CL Protease,3CL-Mpro,Mpro,M Proteinase |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (P132H), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1. | |||
TMPK-00432 |
SARS-COV-2 Spike S1 Protein (hFc & Avi)
Spike protein S1,S glycoprotein Subunit1,S1 protein,Spike,S1... |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S1 Protein (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 102.6 kDa and the accession number is A0A6... | |||
TMPK-00434 |
SARS-COV-2 Spike RBD Protein (hFc & Avi), Biotinylated
S protein RBD,S glycoprotein RBD,Spike protein RBD |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike RBD Protein (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 51.7 kDa and the accession ... | |||
TMPK-00911 |
SARS Spike RBD Protein (His & Avi)
S protein RBD,Spike protein RBD,S glycoprotein RBD |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike RBD Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.9 kDa and the accession number is P59594. | |||
TMPK-01344 |
3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant
M Proteinase,Mpro,3CL-Mpro,3CL Protease |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L167F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.5kDa and the accession number is YP_009725301.1. | |||
TMPH-01283 |
EEF1A1 Protein, Human, Recombinant (His)
EF-1-alpha-1,EEF1A,EEF1A1,Elongation factor 1-alpha 1,EF1A,e... |
Human | E. coli |
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.; (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. | |||
TMPK-00438 |
SARS-COV-2 Spike S Trimer Protein (His & Avi)
COVID-19,S protein,S glycoprotein,Spike glycoprotein |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike S Trimer Protein (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 136.6 kDa and the accession number i... | |||
TMPK-01345 |
3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant
3CL-Mpro,Mpro,M Proteinase,3CL Protease |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein (L50F, E166A, L167F), SARS-COV-2, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 34.5 kDa and the accession number is YP_009725301.1. | |||
TMPH-01284 |
EEF1A1 Protein, Human, Recombinant
EF-Tu,LENG7,EEF1A,eEF1A-1,EF1A,EF-1-alpha-1,EEF1A1,Elongatio... |
Human | E. coli |
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1.; (Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection. | |||
TMPK-01348 |
3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306)
COVID-19,3CL Protease,M Proteinase,3CL Pro,3CL-Mpro,3C-like ... |
SARS-CoV-2 | E. coli |
3CL protease, a viral cysteine proteinase, plays an important role in co-translational proteolytic processing of Coronavirus polyproteins. The 3CL protease cleaves as much as 11 sites in the replicase polyproteins and also releases the key replicative functions of polymerase and helicase. 3CLpro/3C-like Protease Protein, SARS-COV-2, Recombinant (aa 1-306) is expressed in E. coli expression system. The predicted molecular weight is 33.8 kDa and the accession number is YP_009725301.1. | |||
TMPK-00439 |
SARS-COV-2 Spike RBD Protein (His & Avi), Biotinylated
S protein RBD,S glycoprotein RBD,Spike protein RBD |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27 kDa and the accession nu... | |||
TMPK-00912 |
SARS Spike RBD Protein (His & Avi), Biotinylated
S glycoprotein RBD,S protein RBD,Spike protein RBD |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike RBD Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.9 kDa and the accession number... | |||
TMPK-00442 |
SARS-COV-2 (Omicron B.1.1.529) Spike S Trimer Protein (His & Avi), Biotinylated
S glycoprotein,COVID-19,S protein,Spike glycoprotein |
SARS-CoV-2 | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS-COV-2 (Omicron B.1.1.529) Spike S Trimer Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 13... | |||
TMPY-06012 |
SARS-CoV-2 NSP10 Protein
|
SARS-CoV-2 | E. coli |
NSP10 is a major regulator of coronavirus replicase function. NSP10 contains two zinc fingers and binds and stimulates both NSP14 and NSP16 activities. Researchers has found that the nsp10 surface that interacts with nsp14 and nsp16 and possibly other subunits of the viral replication complex may be a target for the development of antiviral compounds against pathogenic coronaviruses. SARS-CoV-2 NSP10 Protein is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and ... | |||
TMPK-00908 |
SARS Spike S1 Protein (hFc & Avi)
Spike protein S1,S1 protein,Spike,S1 protein,S glycoprotein ... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 100.6 kDa and the accession number is P59594. | |||
TMPK-00913 |
SARS Spike S1 Protein (His & Avi), Biotinylated
Spike protein S1,S glycoprotein Subunit1,S1 protein,Spike,S1... |
SARS | HEK293 Cells |
The spike protein (S) of coronavirus (CoV) attaches the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). A defined receptor-binding domain (RBD) on S mediates this interaction.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. SARS Spike S1 Protein (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 75.9 kDa and the accession number ... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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T38297 |
Ribavirin-13C5
Ribavirin-13C5 |
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Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coro... |