148
50
20
170
1
Cat. No. | Product Name | ||
---|---|---|---|
L7900 | 成骨分子库 | 317 compounds | |
317 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L9830 | 抗帕金森病化合物库 | 857 compounds | |
857 种帕金森病相关的化合物集合,可用于高通量和高内涵筛选; | |||
L3800 | NF-κB 通路分子库 | 729 compounds | |
729 个 NF-κB 信号通路相关的小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L1510 | 核受体化合物库 | 531 compounds | |
531 个核受体作用化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L1400 | MAPK 抑制剂库 | 365 compounds | |
365 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合,可用于高通量筛选和高内涵筛选; | |||
L4800 | 血管生成库 | 1353 compounds | |
1353 个高潜力的抑制或促进血管生成的小分子集合,可用于药物靶点开发、血管生成机理研究的高通量筛选,高内涵筛选; | |||
L8300 | 染色质修饰分子库 | 250 compounds | |
250 种染色质化学修饰相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L4000 | 经典已知活性库 | 14439 compounds | |
14439 个已知活性化合物的集合,可用于高通量筛选、高内涵筛选、细胞诱导和靶点确认; | |||
L7500 | 凝血与抗凝化合物库 | 144 compounds | |
144 个化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L1000 | 上市药物库 | 2808 compounds | |
2808 个上市药物化合物集合,可用于高通量筛选和高内涵筛选; | |||
L9000 | 细胞凋亡化合物库 | 1760 compounds | |
1760 种与凋亡相关的生物活性小分子化合物的特有集合,多用于研究肿瘤发生发展机制和抗癌药物筛选等。可用于高通量筛选和高内涵筛选; | |||
L2500 | 人内源代谢化合物库 | 499 compounds | |
499 种内源性生物活性化合物的独特集合,用于高通量、高内涵筛选; | |||
L1010 | FDA上市及药典收录分子库 | 3158 compounds | |
3158 个上市及药典分子集合,可用于高通量筛选和高内涵筛选; | |||
L9600 | 多肽分子库 | 791 compounds | |
791 种多肽类分子,可用于多肽药物开发及信号转导通路和作用机制研究; | |||
L7100 | 抗肥胖化合物库 | 2247 compounds | |
2247 个抗肥胖化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L9420 | 外泌体相关化合物库 | 76 compounds | |
76 种外泌体相关的化合物,可以用于高通量和高内涵筛选; | |||
L2190 | 抗肺癌化合物库 | 1702 compounds | |
1702 种与肺癌相关的化合物,可以用于抗肺癌药物研发和药理研究; | |||
L2194 | 抗结直肠癌化合物库 | 1545 compounds | |
1545 种与结直肠癌相关的化合物,可以用于高通量和高内涵筛选; | |||
L8500 | HIF-1化合物库 | 1336 compounds | |
1336 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究; | |||
DO1200 | 药物靶点库 | 53200 compounds | |
数量多,含53200种小分子化合物,是高通量筛选的有力工具; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3169 |
KC7F2
|
HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
KC7F2 是缺氧诱导因子HIF-1通道抑制剂,在 LN229-HRE-AP 细胞中的IC50=20 μM,可用作抗癌试剂。 | |||
T22022 |
Adaptaquin
|
HIF | Angiogenesis; Chromatin/Epigenetic |
Adaptaquin 是缺氧诱导因子脯氨酰羟化酶(HIF-PH)的抑制剂。 | |||
T0244 |
Tilorone dihydrochloride
|
Influenza Virus; HIF/HIF Prolyl-Hydroxylase; IFNAR | Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology |
Tilorone dihydrochloride 是一种具有口服活性的干扰素诱导剂,具有抗肿瘤和抗炎作用。 | |||
T12675L |
PT2399
|
HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
PT2399 是高选择性的HIF-2α拮抗剂,能直接结合 HIF-2α PAS B 结构域,IC50=6 nM,具有显著的体内抗肿瘤特性。 | |||
T13050 |
SYP-5
|
HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
SYP-5 是新型HIF-1抑制剂,阻碍肿瘤细胞侵袭和血管生成。 | |||
T5392 |
TP0463518
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
TP0463518 是缺氧诱导因子脯氨酰羟化酶抑制剂,能够作用于人 PHD2(Ki= 5.3 nM)。它还抑制人PHD1/PHD3,IC50分别为 18 和 63 nM,以及猴 PHD2(IC50=22 nM)。 | |||
T5537 |
IDF-11774
|
HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
IDF-11774 是新型低氧诱导因子 α (HIFα)-1的抑制剂,其 IC50=3.65 μM。。 | |||
T13398 |
ZINC13466751
|
HIF | Angiogenesis; Chromatin/Epigenetic |
ZINC13466751 是有效的 HIF-1α/von Hippel-Lindau 相互作用抑制剂,抑制作用的 IC50为 2.0 µM。 | |||
T7848 |
PT-2385
|
HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
PT-2385 是一种选择性HIF-2α抑制剂,Ki< 50 nM。 | |||
T4022 |
QS11
QS 11 |
GTPase | GPCR/G Protein |
QS11 是一种ARFGAP1抑制剂(EC50:1.5 µM)。QS 11 能抑制 ARFGAP 过表达的乳腺癌细胞迁移。QS 11 通过影响蛋白质运输来增强 Wnt/β-catenin 信号。 | |||
T7880 |
IOX4
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
IOX4 是选择性 PHD2抑制剂,IC50=1.6 nM,在细胞和野生型小鼠中诱导 HIFα表达,可透过血脑屏障。它与 PHD2 特性位点的 2-氧代戊二酸竞争并置换。 | |||
T4106 |
MK-8617
MK8617 |
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
MK-8617 是一种口服具有活力的低氧诱导因子脯氨酰羟化酶 1-3 (HIF PHD1-3) 泛抑制剂,对于PHD2的IC50=1 nM。 | |||
T2652 |
Molidustat
BAY 85-3934 |
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
Molidustat (BAY 85-3934) 是新型HIF-PH 抑制剂,对PHD1(IC50:480 nM)、PHD2(IC50:280 nM)、PHD3(IC50:450 nM)。 | |||
T2488 |
BAY 87-2243
|
Ferroptosis; HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Metabolism |
BAY 87-2243 是一种选择性的低氧诱导因子-1 抑制剂。 | |||
T3197 |
Daprodustat
GSK1278863 |
HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
Daprodustat 是一种口服具有活力的缺氧诱导因子脯氨酰羟化酶 (HIFPH) 抑制剂,可用于与慢性肾病相关的贫血病的研究。 | |||
T21653 |
1,4-DPCA
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
1,4-DPCA 是一种脯氨酰羟化酶抑制剂,对人源包皮成纤维细胞中胶原羟基化的 IC50 为 2.4 μM,对因子抑制 HIF (FIH) 的 IC50 为 60 μM。 | |||
T64336 |
Izilendustat
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate 是一种脯氨酰羟化酶抑制剂。 | |||
T15219 |
Enarodustat
JTZ-951 |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Enarodustat (JTZ-951) 是口服具有活力的 hypoxia-inducible factor prolyl hydroxylase 抑制剂,EC50=0.22 μM,有用于肾性贫血症的研究潜力。 | |||
T11561 |
HIF-2α-IN-2
|
HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
HIF-2α-IN-2 是低氧诱导因子抑制剂,IC50=16 nM。 | |||
T7802 |
M1001
|
HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
M1001 是较弱的HIF-2α激动剂,直接与 HIF-2α PAS-B 结构域结合,Kd=667 nM,能够提高 HIF-2α-ARNT 复合体之间的稳定性。 | |||
T21806 |
HNHA
|
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
HNHA 是组蛋白去乙酰化酶抑制剂。它通过 p21诱导将细胞周期阻滞在 G1/S 期,抑制肿瘤生长及肿瘤新生血管形成。HNHA 可能是一种有效的抗乳腺癌药物。 | |||
T29797 |
AKB-6899
AKB6899 |
VEGFR; HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism; Tyrosine Kinase/Adaptors |
AKB-6899 是脯氨酰羟化酶结构域 3 (PHD3) 的抑制剂,可增加 GM-CSF 处理的巨噬细胞产生的 VEGF 受体的可溶形式 (sVEGFR-1)。 AKB-6899 能稳定 HIF-2α,从而诱导肿瘤相关巨噬细胞产生 sVEGFR-1 并减少肿瘤生长。 | |||
T21807 |
INCA-6
Triptycene-1,4-quinone |
Others | Others |
INCA-6 (Triptycene-1,4-quinone) 是细胞渗透性的 NFAT 抑制剂。INCA-6 通过特异性阻断 NFAT 底物靶向钙调神经磷酸酶位点,有效抑制calcineurin (CN)-NFAT 信号传导。 | |||
T1823 |
IOX2
IOX 2,JICL38 |
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
IOX2 (IOX 2) 是特异性的脯氨酰羟化酶-2 抑制剂,IC50=22 nM。 | |||
T6961 |
PX-478
PX-478 2HCl |
HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy | Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism |
PX-478 是一种 HIF-1α 抑制剂,具有选择性、口服活性和血脑屏障渗透性。PX-478 具有抗肿瘤活性,还可以保护糖尿病中的胰腺 β 细胞功能,用于 2 型糖尿病的研究。 | |||
T9627 |
PHD-1-IN-1
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
PHD-1-IN-1 是口服有效的缺氧诱导因子脯氨酰羟化酶结构域 1抑制剂,IC50为 0.034 μM。它与活性位 Fe2+具有独特的单齿结合相互作用,并诱导形成一个 “Arg367-out” 口袋。 | |||
T3180 |
JNJ-42041935
HIF-PHD Inhibitor II |
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
JNJ-42041935 (HIF-PHD Inhibitor II) 是一种高效的,竞争性的、选择性的脯氨酰羟化酶PHD 抑制剂,抑制PHD1(pKi= 7.91±0.04),PHD2 (pKi= 7.29 ±0.05) 和 PHD3 (pKi= 7.65±0.09)。 | |||
T1613 |
Hydralazine hydrochloride
Hydralazine HCl,Apresoline,盐酸肼屈嗪 |
MAO; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Neuroscience |
Hydralazine hydrochloride (Apresoline) 是一种直接作用的血管舒张剂,可抗高血压。 | |||
T19786 |
Hematin
Ferrihemate,Ferriheme hydroxide,Ferriheme,Ferrihemic acid,羟高铁血红素 |
Others | Others |
Hematin (Ferrihemic acid) 是含铁卟啉,可以结合止血蛋白诱导其失活,降低凝血因子的活性以及阻碍纤维蛋白凝块的溶解。它可用于研究急性卟啉症和癌症。 | |||
T16679 |
Belzutifan
PT2977,MK-6482 |
HIF | Angiogenesis; Chromatin/Epigenetic |
Belzutifan (MK-6482) 是具有口服活性的 HIF-2α选择性抑制剂,IC50为 9 nM。Belzutifan 具有提高的效力和改善的药代动力学特征。Belzutifan (MK-6482) 可以抑制透明细胞肾细胞癌。 | |||
T13289 |
EHP-101
VCE-004.8 |
Cannabinoid Receptor; HIF/HIF Prolyl-Hydroxylase; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism |
EHP-101 (VCE-004.8) 是一种口服有效的特异性PPARγ和CB2受体双重激动剂,可抑制脯氨酰-羟化酶(PHDs) 并激活HIF 通路。它是一种半合成的多靶点大麻喹啉,可减弱脂肪生成并防止饮食诱导的肥胖,具有抗炎活性。 | |||
T50099 |
HIF-2α-IN-4
|
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
HIF-2a translation inhibitor 是一种有效的HIF-2α翻译抑制剂,IC50=5 μM,能够抑制组成型和缺氧诱导的 HIF-2α 蛋白表达。其中 HIF-2α-IN-4 将 5'UTR 铁响应元件与氧传感联系起来。 | |||
T9890 |
HIF1-IN-3
Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]- |
HIF | Angiogenesis; Chromatin/Epigenetic |
HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) 是HIF-1的有效抑制剂(EC50 = 0.9 μM),可用于抗癌的研究。 | |||
T2515 |
Roxadustat
ASP1517,FG-4592,罗沙司他 |
Ferroptosis; HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Metabolism |
Roxadustat (FG-4592) 是一种口服生物可利用的缺氧诱导因子脯氨酰羟化酶抑制剂,通过增加内源性促红细胞生成素、改善铁调节和降低铁调素来促进红细胞生成,具有潜在的抗贫血活性。 | |||
T1939 |
DMOG
Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine,二甲基草酰甘氨酸 |
HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy | Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism |
DMOG (Dimethyloxalylglycine) 是一种 α-酮戊二酸辅因子的拮抗剂,一种 HIF 脯氨酰羟化酶 (HIF-PH) 的抑制剂,可导致蛋白 HIF-1α 的积聚和稳定。DMOG 可以诱导细胞自噬,还是一种促血管生成剂。 | |||
T0153 |
Oltipraz
吡噻硫酮,NSC 347901,RP 35972 |
HIF/HIF Prolyl-Hydroxylase; HIV Protease; Reverse Transcriptase; Nrf2; HIF | Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Proteases/Proteasome |
Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活,IC50为 10 μM,浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。 | |||
T3289 |
Amifostine
氨磷汀,Ethyol,WR2721,Gammaphos |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Amifostine (Ethyol) 是一种广谱细胞保护剂和辐射防护剂,具有清除自由基的作用。它可选择性保护正常组织免受放射线和化学疗法造成的损害。它是有效的 HIF-α1和 p53诱导剂,可降低肾脏毒性并具有抗血管生成作用。 | |||
T2445 |
FG-2216
YM-311,FG2216,FG 2216 |
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
FG-2216 (YM-311) 是一种有效的、口服具有活力的HIF 脯氨酰羟化酶-2 (PHD2) 抑制剂,IC50=3.9 nM。它在体内能够诱导促红细胞生成素生成和胎儿血红蛋白的表达。 | |||
T0446 |
Naphazoline hydrochloride
盐酸萘甲唑啉,Albalon,Rhinantin,Naphazoline HCl |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Naphazoline hydrochloride (Naphazoline HCl) 是一种咪唑啉衍生物,是一种眼血管收缩剂。 | |||
T3494 |
LW6
HIF-1α inhibitor,CAY10585,LW8 |
Apoptosis; Dehydrogenase; HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Metabolism |
LW6 (HIF-1α inhibitor) 是一种新型 HIF-1抑制剂,IC50值为 4.4 μM。它降低 HIF-1α蛋白表达,但不影响 HIF-1β 表达。 | |||
T6381 |
Amifostine trihydrate
Ethyol trihydrate,WR2721,三水氨磷汀,Amifostine |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Amifostine trihydrate (WR2721) 是一种广谱细胞保护剂和辐射防护剂。它可选择性保护正常组织免受放射线和化学疗法造成的损害。它是有效的HIF-α1和p53诱导剂。它通过清除氧衍生的自由基来保护细胞免受损伤。它可降低肾脏毒性并具有抗血管生成作用。 | |||
T4651 |
Vadadustat
N-(5-(3-氯苯基)-3-羟基吡啶-2-羰基)甘氨酸,PG-1016548,AKB-6548 |
HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
Vadadustat 是一种可滴定口服的缺氧诱导因子脯氨酰羟化酶 (HIF-PH) 抑制剂,是一种促红细胞生成剂,在动物慢性肾脏疾病模型中,有用于贫血的研究潜力。 | |||
T15396 |
GN44028
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine |
HIF | Angiogenesis; Chromatin/Epigenetic |
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) 是缺氧诱导因子(HIF)-1的有效抑制剂,其 IC50=14 nM。它可以抑制低氧诱导的 HIF-1α 的转录特性,但不抑制 HIF-1α mRNA 的表达,HIF-1α 蛋白的累积或HIF-1α/HIF-1β 的异缘二聚化。 | |||
T1101 |
Minocycline hydrochloride
Minocycline HCl,盐酸米诺环素,美满霉素 |
HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic | Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Minocycline hydrochloride (Minocycline HCl) 属于四环素类抗生素,具有出色的吸收和组织渗透性。Minocycline hydrochloride 是一种广谱的抗菌剂,可用于多种细菌感染以及痤疮的治疗。 | |||
T1637 |
Deferoxamine Mesylate
desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM,去铁铵,甲磺酸去铁胺 |
Mitophagy; Beta Amyloid; Others; Ferroptosis; HIF/HIF Prolyl-Hydroxylase; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Metabolism; Neuroscience; Others |
Deferoxamine Mesylate (DFOM) 是一种铁螯合剂和铁死亡抑制剂。Deferoxamine Mesylate 可将游离铁结合成稳定的复合物,减少铁的积累。Deferoxamine Mesylate 可以上调 HIF-1α 水平,诱导细胞凋亡。 | |||
T6823 |
E3330
|
HIF/HIF Prolyl-Hydroxylase; DNA/RNA Synthesis | Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
E3330 是一种口服有效的选择性 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂,可抑制NF-κB DNA 结合活性。它阻断 TNF-α 诱导的肝癌细胞系中 IL-8 的激活,可以抑制癌细胞的生长和迁移,具有抗癌活性。 | |||
T62356 |
Mardepodect hydrochloride
PF-2545920 HCl,Mardepodect HCl,MP-10 HCl,PF-02545920 HCl |
Apoptosis; PDE | Apoptosis; Metabolism |
Mardepodect hydrochloride (Mardepodect HCl) 是一种可穿过血脑屏障且具有口服活性的、选择性和高效性的 PDE10A 抑制剂(IC50 :0.37 nM)。Mardepodect hydrochloride 可上调编码特定生长因子、转录因子、细胞信号分子和细胞表面蛋白的基因,同时下调广泛的可靶向细胞周期和细胞凋亡相关基因。 | |||
TP2221L |
ANP (1-11), rat acetate
Atrial natriuretic factor (1-11) acetate,ANP (1-11), rat醋酸盐,Atriopeptide (1-11) acetate |
Others | Others |
ANP (1-11), rat acetate (Atrial natriuretic factor (1-11) acetate) 是心房利钠因子之一,是 CRF 刺激的 ACTH 分泌的抑制剂。 | |||
T16430 |
Paliroden
SR 57667,SR 57667B |
Others | Others |
Paliroden 是一种可口服和用于补充神经营养的非肽类化合物,能够刺激内源性神经营养素因子的合成,用于研究阿尔兹海默症和帕金森症等神经系统类疾病。 | |||
T60024 |
CFT7455
Cemsidomide |
Ligand for E3 Ligase | PROTAC |
CFT7455 (Cemsidomide) 是一种抗癌剂,对 cereblon E3 连接酶具有高亲和力,Kd 为 0.9 nM。 CFT7455 是锌指转录因子 Ikaros (IKZF1) 和 Aiolos (IKZF3) 的口服活性降解剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T6S0071 |
Fraxinellone
|
HIF/HIF Prolyl-Hydroxylase; STAT; PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Metabolism; Stem Cells |
Fraxinellone 是从白鲜的根皮中分离出来的一种天然产物,是PD-L1抑制剂,可抑制HIF-1α蛋白质合成。它通过靶向 PD-L1,有用于癌症免疫的潜力。 | |||
T5S2347 |
Deoxyshikonin
去氧紫草素,Arnebin 7 |
Others; HIF/HIF Prolyl-Hydroxylase; Antibacterial | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Others |
Deoxyshikonin (Arnebin 7) 是从紫草中分离的天然产物,具有抗肿瘤活性,在体外具有促血管生成作用。它和没食子酸十二烷基酯在体内外均与青霉素有显着的协同抗菌活性。 | |||
TL0001 |
dencichine
L-Dencichin,ODAP,Dencichin,三七素 |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Dencichine (ODAP) 是抑制从三七中分到的非蛋白氨基酸,可抑制 HIF-prolyl hydroxylase-2 的活性。 | |||
T0429 |
Glucosamine
Chitosamine,D-Glucosamine,氨基葡萄糖,葡糖胺 |
MMP; Others; TNF; NF-κB; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; CFTR; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Others; Proteases/Proteasome |
Glucosamine (Chitosamine) 是软骨基质和滑液中糖胺聚糖的天然成分,常用作骨关节炎的治疗方法。它也是一种氨基糖,是糖基化蛋白和脂质生化合成的突出前体,用作膳食补充剂。 | |||
T2763 |
Panaxadiol
人参二醇,20(R)-Panaxadiol |
Others; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; Others |
Panaxadiol (20(R)-Panaxadiol) 是从人参根中获得,具有神经保护和抗肿瘤作用,能够抑制程序性细胞死亡配体-1(PD-L1)的表达和肿瘤增殖。 | |||
T5684 |
Ethyl 3,4-dihydroxybenzoate
|
Apoptosis; Others; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; NO Synthase; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Others |
Ethyl 3,4-dihydroxybenzoate 是从花生种子的种皮中发现的脯氨酰羟化酶抑制剂,是一种抗氧化剂。它是胶原蛋白合成抑制剂,具有骨骼保护作用。它通过激活 NO 合酶并产生线粒体 ROS 来保护心肌,可诱导 ESCC 细胞自噬和凋亡。 | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 | |||
T2792 |
Glucosamine sulfate
硫酸葡萄糖胺,硫酸氨基葡萄糖,D-Glucosamine sulphate,D-Glucosaminesulfate |
MMP; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; Autophagy | Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Proteases/Proteasome |
Glucosamine sulfate (D-Glucosaminesulfate) 是软骨基质和滑液中糖胺聚糖的天然成分,常用作骨关节炎的治疗方法。它也是一种氨基糖,是糖基化蛋白和脂质生化合成的突出前体,用作膳食补充剂。 | |||
T1152 |
Albendazole
SKF-62979,阿苯达唑 |
HIF/HIF Prolyl-Hydroxylase; Microtubule Associated; Antibiotic; Parasite | Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism; Microbiology/Virology |
Albendazole (SKF-62979) 是一种广谱抗寄生虫剂,具有高效,低宿主毒性的特点。 它用于研究人类和动物的胃肠道寄生虫。 | |||
T2805 |
Chlorogenic Acid
NSC-407296,3-O-Caffeoylquinic acid,Heriguard,绿原酸 |
Others; Influenza Virus; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; Antibacterial | Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Others |
Chlorogenic acid 作为金银花中的主要酚类化合物,具有潜在的抗氧化,抗菌抗炎和抗癌活性,可用于晚期癌症和葡萄糖耐量受损治疗等相关研究。 | |||
T1205 |
Chloramphenicol
Chlornitromycin,Levomycetin,Chloromycetin,氯霉素 |
ribosome; HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic | Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Chloramphenicol (Chloromycetin) 是一种广谱抗生素,有效抑制细菌蛋白质生物合成。它主要作用于细菌 70S 核糖体的 50S 亚基,对肽基转移酶有活性,抑制肽键的形成。 | |||
T11589 |
Hydroxycitric acid tripotassium hydrate
柠檬酸钾一水合物,三水合钾柠檬酸,Potassium citrate monohydrate |
ATP Citrate Lyase; HIF/HIF Prolyl-Hydroxylase; HIF | Angiogenesis; Chromatin/Epigenetic; Metabolism |
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) 是一种藤黄果的主要活性成分,也是一种柠檬酸的衍生物。它可竞争性抑制柠檬酸裂解酶 (ATP citrate lyase) ,并具有减肥作用。它有效抑制结石形成,并抑制HIF,具有抗氧化,抗炎和抗肿瘤活性。 | |||
T2941 |
Glucosamine hydrochloride
Chitosamine hydrochloride,盐酸氨基葡萄糖,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride |
Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite; Autophagy | Autophagy; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB |
Glucosamine hydrochloride (Chitosamine hydrochloride) 是软骨基质和滑液中糖胺聚糖的天然成分,常用作骨关节炎的治疗方法。它也是一种氨基糖,是糖基化蛋白和脂质生化合成的突出前体,用作膳食补充剂。 | |||
T0256 |
Citric acid trilithium salt tetrahydrate
Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate |
Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR | Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells |
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。 | |||
T5S1569 |
AKBA
乙酰基-11-酮基-beta-乳香酸,3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid |
Others; Reactive Oxygen Species; HIF/HIF Prolyl-Hydroxylase; Endogenous Metabolite | Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; Others |
AKBA (3-O-Acetyl-11-keto-beta-boswellic acid) 是一种从乳香中分离的天然成分,是新颖的 Nrf2 的活化剂。 | |||
TN1836 |
Kudinoside D
|
LDL; AMPK; PPAR | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling |
Kudinoside D 是 Ilex kudingcha 中三萜皂苷的主要天然成分之一。它能够调节 3T3-L1 脂肪细胞中 AMPK 途径,并可抑制脂肪形成。 | |||
T19603 |
Vitamin K
Kephton,维生素K,Vitamin K1(20) |
Endogenous Metabolite | Metabolism |
Vitamin K (Kephton) 具有凝血作用,对凝血因子、基质-Gla 蛋白和骨钙素很重要。 | |||
T11012 |
Dextran
Dextran 40,葡聚糖 |
Platelet aggregation | Others |
Dextran 对血小板聚集和凝血因子有抑制作用,用作增加血浆容量的药剂。 | |||
T8244 |
Raspberry ketone glucoside
覆盆子酮葡糖苷,树莓苷,覆盆子酮葡萄糖甙 |
Others | Others |
Raspberry ketone glucoside 是一种山莓果实中的天然产物。它能够抑制黑色素的合成。 | |||
T5754 |
Kavain
|
NF-κB; GABA Receptor | Membrane transporter/Ion channel; Neuroscience; NF-κB |
Kavain 是从卡瓦胡椒中分离出来的卡瓦酸内酯,可以正向调控GABAA 受体,具有抗焦虑作用。 | |||
T8301 |
Amaranth
Acid Red 27,酸性红 27 |
Others | Others |
Amaranth (Acid Red 27) 是一种阴离子染料, 可应用到天然和合成纤维、皮革、纸张及苯酚-甲醛树脂。它是一种暗红色至紫色的偶氮染料,可用作食品染料和化妆品。 | |||
TN1664 |
Ganoderic acid H
|
NF-κB; DNA/RNA Synthesis; CDK | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; NF-κB |
Ganoderic acid H 是一种羊毛脂烷型三萜,提取自灵芝中。它能够抑制转录因子AP-1 和 NF-kappaB 信号,并抑制乳腺癌细胞细胞的生长和入侵。 | |||
TN2121 |
3,5,7,3′,4′-Pentamethoxyflavone
栎精-3,5,7,3',4'-五甲醚,槲皮素3,5,7,3',4'-五甲基醚,Quercetin 3,5,7,3,4-pentamethyl ether |
Others | Others |
3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) 是一种分离自小花山奈中的多甲氧基黄酮。在分化早期,它可以调控转录因子,促进 3T3-L1 前脂肪细胞形成脂肪。 | |||
T14291 |
Anisindione
|
Others | Others |
Anisindione 是合成的抗凝血剂,对活性促凝因子II,VII,IX 和X 的形成具有抑制作用。 | |||
T3887 |
Rosarin
|
Others | Others |
Rosarin 是从玫瑰红景天中分离出来的肉桂醇糖苷。它抑制小鼠肾脏和大脑前额皮层中促炎因子 iNOS,IL-1β 和 TNF-α 的表达。它具有抗炎和神经保护作用。 | |||
T2336 |
Vitamin K2
Menatetrenone,四烯甲萘醌 |
Endogenous Metabolite | Metabolism |
Vitamin K2 (Menatetrenone) 是内源性代谢产物的一种。 | |||
T5770 |
Alisol B
|
RANKL/RANK | NF-κB |
Alisol B 是一种具有用于骨科疾病研究潜力的化合物,通过分化破骨细胞发挥其功能。 | |||
T5S1103 |
Isoliensinine
异莲心碱,Isoliensinin |
Apoptosis; Antioxidant | Apoptosis; oxidation-reduction |
Isoliensinine (Isoliensinin) 是从水芙蓉种子胚中提取的一种双苄基异喹啉生物碱,能诱导三阴性乳腺癌细胞凋亡,具有抗氧化、抗炎、抗癌活性。 | |||
TN4234 |
Hydrangenol
|
NOS; NF-κB; Nrf2; NO Synthase; Antifection; Autophagy | Autophagy; Immunology/Inflammation; Microbiology/Virology; NF-κB |
Hydrangenol 是一种天然产物,可从绣球花 (Hydrangea serrata) 的叶中分离。Hydrangenol 是口服有效的抗光老化化合物,可以预防皱纹的形成。Hydrangenol 可以降低 MMP 和炎症细胞因子的表达,增加保湿因子和抗氧化基因的水平。 | |||
TN1237 |
3-O-Methylgallic acid
3,4-Dihydroxy-5-methoxybenzoic acid,3-O-甲基没食子酸 |
Apoptosis; NF-κB; OCT; DNA/RNA Synthesis; STAT | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; JAK/STAT signaling; Membrane transporter/Ion channel; NF-κB; Stem Cells |
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) 是一种花青素代谢产物,具有强大的抗氧化能力。它还诱导细胞凋亡并具有抗癌作用,可抑制 Caco-2 细胞增殖,IC50值为 24.1 μM。 | |||
T37341 |
N-Acetyltyramine
|
Antibacterial | Microbiology/Virology |
N-Acetyltyramine 是一种群体感应抑制剂,由溶藻弧菌 M3-10 产生。N-Acetyltyramine 可以抑制C. violaceumATCC 12472 的群体感应。它可以逆转阿霉素耐药白血病 P388 细胞的耐药性。 | |||
T38248 |
2-Ethylpyrazine
|
Endogenous Metabolite; NO Synthase | Immunology/Inflammation; Metabolism |
2-Ethylpyrazine 存在与烘焙后的咖啡豆中,是一种挥发性化合物 。2-Ethylpyrazine 通过内皮衍生的松弛因子的活动诱导血管舒张。2-Ethylpyrazine 通过内皮内皮NO 合酶的作用激活NO 合成。2-Ethylpyrazine 通过诱导NO 释放和增加外周血流量来诱导血管舒张。 | |||
T1611 |
Isotretinoin
13-cis-Retinoic acid,异维A酸 |
Retinoid Receptor; Endogenous Metabolite; Autophagy | Autophagy; Metabolism |
Isotretinoin (13-cis-Retinoic acid) 是一种天然存在的维甲酸,具有潜在的抗肿瘤活性。 它结合并激活核视黄酸受体 (RAR), 活化的 RARs 作为促进细胞分化和凋亡的转录因子。它是一种类维生素A 和维生素A 衍生物,用于治疗严重的痤疮和某些形式的皮肤、头颈癌。 | |||
TN5888 |
Toddaculin
|
Others | Others |
Toddaculin 是一种天然香豆素,抑制过度的破骨细胞活性并增强成骨细胞分化和矿化。它可诱导白血病细胞分化和凋亡,具有抗炎活性。 | |||
T6S1049 |
Wilforine
|
ATPase | Membrane transporter/Ion channel |
Wilforine 是一倍半萜吡啶化合物,T. wilfordii 植物中的重要生物活性化合物,可有效治疗特发性肺纤维化。它具有抗炎和杀虫活性。 | |||
T4944 |
Nervonic acid
cis-15-Tetracosenoic acid,神经酸,Selacholeic acid |
Endogenous Metabolite | Metabolism |
Nervonic acid (Selacholeic acid) 是在髓磷脂生物合成中很重要的单不饱和脂肪酸。 | |||
T9113 |
Myristicin
Myristicine,肉豆蔻醚 |
IL Receptor; Anti-infection; BCL; P450; PARP; 5-HT Receptor; Caspase; GABA Receptor; NO Synthase | Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome |
Myristicin (Myristicine) 是一种在香料和伞形植物中发现的天然产物。肉豆蔻素具有抗胆碱能、抗菌和肝保护作用,还具有抗炎作用,其通过钙途径抑制dsrna 刺激的巨噬细胞中的NO、细胞因子、趋化因子和生长因子。Myristicin 可以诱导细胞凋亡,其特征是改变线粒体膜电位、细胞色素c 释放、Caspase-3激活、parp 切割和DNA 断裂。 | |||
T3123 |
Allicin
|
ERK; IL Receptor; Others; IκB/IKK; p38 MAPK; TNF; ROS; Caspase; Antifection | Apoptosis; Immunology/Inflammation; MAPK; Microbiology/Virology; NF-κB; Others; Proteases/Proteasome |
Allicin 具有抗氧化、杀菌、抗癌、抗炎活性,对肠上皮细胞具有抑制性免疫调节作用。 Allicin 能显着抑制胰岛素诱导的血管平滑肌细胞的增殖和迁移,这可能与抑制 ERK 信号通路的激活有关。 Allicin 有利于降低高胆固醇血症大鼠的血液胆固醇、甘油三酯水平和收缩压,它可能有益于影响动脉粥样硬化的两个危险因素——高脂血症和高血压。 | |||
T5S2343 |
Acetylshikonin
乙酰紫草素,Acetyl shikonin |
Others; P450; AChE | Metabolism; Neuroscience; Others |
Acetylshikonin 来源于紫草根,具有抗癌、抗炎作用。它是一种 AChE 抑制剂,具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂,对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。 | |||
TN1897 |
Luteone
羽扇豆异黄酮 |
Antifection | Microbiology/Virology |
Luteone possesses antifungal activity sufficient to support its proposed role as pre-infectional resistance factors. | |||
TN2228 |
Soyasaponin Aa
大豆皂苷 AA,大豆皂苷Aa |
PPAR | DNA Damage/DNA Repair; Metabolism |
Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factors PPARγ and C/EBPα± in 3T3-L1 adipo | |||
T80018 |
cis-2-Dodecenoic acid
|
Others | Others |
cis-2-Dodecenoic acid,最初在Burkholderia cenocepacia中被发现,能够干扰细菌的群体感应系统,从而抑制细菌生物膜的形成和毒力因子的产生。 | |||
TMA1944 |
Protopine hydrochloride
|
EGFR; cAMP | Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.Protopine seems to inhibit the heterotypic cell adhesion between MD | |||
T39605 |
β-D-Glucopyranosyl abscisate
ABA-GE,β-D-Glucopyranosyl abscisate,(S)-cis,trans-Abscisicacidglucosylester |
Others | Others |
β-D-Glucopyranosyl abscisate (ABA-GE) is a hydrolyzable conjugate of abscisic acid (ABA), which predominantly accumulates in the vacuole and likely in the endoplasmic reticulum. The deconjugation of β-D-Glucopyranosyl abscisate enables a swift release of free ABA in response to abiotic stress factors like dehydration and salt stress. β-D-Glucopyranosyl abscisate plays a crucial role in maintaining ABA homeostasis. | |||
TN6524 |
Irilone
|
||
Irilone has immunomodulatory, and α-amylase inhibitory activities, it exhibits the selective inhibition toward CYP3 A4 rather than other major human CYPs. Irilone exhibited prominent antioxidant activities with the IC50 value of 10.46μM. Irilone potentiat | |||
TN5369 |
Dehydroleucodine
Dehydroleucodin |
||
Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating adipocyte differentiation by modulat | |||
TN4092 | Galanolactone | 5-HT Receptor | GPCR/G Protein; Neuroscience |
Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors, it has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. Galanolactone exerts anti-obesity effect through do | |||
TN2177 |
Sanggenol L
|
Apoptosis | Apoptosis |
Sanggenol L 是一种来自是桑树根皮的化合物,抑制细胞生长,通过激活半胱天冬酶级联反应和细胞凋亡诱导因子促进黑色素瘤皮肤癌细胞的凋亡细胞死亡。 Sanggenol L 具有抗癌活性和抗增殖作用,可用于研究前列腺癌。 | |||
TN3070 |
4beta-Hydroxywithanolide E
|
PARP; HSP; NF-κB; COX | Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progression and develop into a dietary chemopreventive agent, it affects alternative splicing by mo | |||
T75611 |
Tibesaikosaponin V
|
Others | Others |
Tibesaikosaponin V 是一种三萜双糖苷,可从北柴胡 (Bupleurum chinense DC) 的根的甲醇提取物中分离得到。Tibesaikosaponin V (TKV) 是一种三萜双糖苷,可从 Bupleurum chinense DC 根的甲醇提取物中分离得到。Tibesaikosaponin V 抑制脂质积累和甘油三酯含量的发生,对脂肪细胞没有细胞毒性。Tibesaikosaponin V 抑制核转录因子的 mRNA 表达,例如过氧化物酶体增殖物激活受体 γ (PPARγ) 和 CCAAT/增强子结合蛋白 α (C/EBPα)。Tibesaikosaponin V 抑制 3T3-L1 前脂肪细胞分化。Tibesaikosaponin V 可用于肥胖及其相关代谢紊乱的研究。 | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04029 |
Protein C Protein, Mouse, Recombinant (His)
PC,PROC,protein C, inactivator of coagulation factors |
Mouse | HEK293 Cells |
Protein C Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.1 kDa and the accession number is NP_032960.3. | |||
TMPY-03880 |
Protein C Protein, Human, Recombinant (His)
PROC,APC,THPH4,protein C, inactivator of coagulation fac... |
Human | HEK293 Cells |
Protein C Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 51.5 kDa and the accession number is P04070. | |||
TMPJ-01470 |
SCF Protein, Human, Recombinant
Mast Cell Growth Factor,c-Kit ligand,KITLG,MGF,Stem Cell Fac... |
Human | E. coli |
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors. | |||
TMPK-01393 |
Tenascin Protein, Mouse, Recombinant (His)
Hexabrachion,Hxb,TN-C,TN,TNC,Tenascin-C |
Mouse | HEK293 Cells |
Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin. Tenascin-C has many extracellular binding partners, including matrix components, soluble factors and pathogens; it also influences cell phenotype directly through interactions with cell surface receptors. Tena... | |||
TMPK-01392 |
Tenascin Protein, Human, Recombinant (His)
Tenascin-C,TNC,TN,Hexabrachion,Hxb,TN-C |
Human | HEK293 Cells |
Tenascin-C (TNC) is a hexameric, multimodular extracellular matrix protein with several molecular forms that are created through alternative splicing and protein modifications. It is highly conserved amongst vertebrates, and molecular phylogeny indicates that it evolved before fibronectin. Tenascin-C has many extracellular binding partners, including matrix components, soluble factors and pathogens; it also influences cell phenotype directly through interactions with cell surface receptors. Tena... | |||
TMPJ-00135 |
BDNF Protein, Human/Murine/Rat, Recombinant
BDNF,Abrineurin,Brain-Derived Neurotrophic Factor |
Human,Mouse,Rat | E. coli |
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. ... | |||
TMPJ-00842 |
FGF-2 Protein, Rat, Recombinant
bFGF,Heparin-Binding Growth Factor 2,FGFB,Fibroblast Growth ... |
Rat | E. coli |
FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF-basic is a non-glycosylated heparin binding g... | |||
TMPJ-00864 |
VEGF165 Protein, Human, Recombinant
Vascular Endothelial Growth Factor Isoform 165,血管内皮生长因子,VEGF... |
Human | HEK293 Cells |
Human Vascular endothelial growth factor (VEGF), also known as VEGF-A and vascular permeability factor (VPF), belongs to the platelet-derived growth factor family of cysteine-knot growth factors. It is a potent activator in vasculogenesis and angiogenesis both physiologically and pathologically. VEGF-A has 8 differently spliced isoforms, of which VEGF165 is the most abundant one. VEGF165 is a disulfide-linked homodimer consisting of two glycosylated 165 amino acid polypeptide chains. VEGF stimul... | |||
TMPJ-00327 |
M-CSF/CSF1 Protein, Human, Recombinant (His)
Lanimostim,M-CSF,CSF-1,MCSF,CSF1,集落刺激因子,Macrophage Colony-St... |
Human | HEK293 Cells |
Macrophage Colony-Stimulating Factors (m-csf) are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and themonocytes-macrophages. CSF-1 promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulatio... | |||
TMPY-02907 |
FGF-19 Protein, Human, Recombinant
fibroblast growth factor 19,FGF19 |
Human | E. coli |
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglyca... | |||
TMPJ-01469 |
NGF Protein, Human, Recombinant (E. colli)
NGFB,神经生长因子,β-NGF,NGF,Beta-Nerve Growth Factor,β-Nerve Growt... |
Mouse | E. coli |
NGF is the first member discovered in the Neurotrophin family, which includes brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an impo... | |||
TMPY-02115 |
R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)
CRISTIN1,THSD2,R-spondin 3,PWTSR |
Human | HEK293 Cells |
R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify s... | |||
TMPY-02030 |
CD82 Protein, Human, Recombinant (His)
CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,TSPAN27,ST6,IA4,GR1... |
Human | HEK293 Cells |
CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud... | |||
TMPY-03431 |
HDAC4 Protein, Human, Recombinant (aa 612-1084)
histone deacetylase 4,HA6116,HDAC-4,HD4,BDMR,HDAC-A,AHO3,HDA... |
Human | Baculovirus Insect Cells |
HDAC4 (histone deacetylase 4), belongs to class II of the histone deacetylase/AcuC/APhA family. Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. Th... | |||
TMPY-02028 |
RON/CD136 Protein, Human, Recombinant (His)
CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON |
Human | HEK293 Cells |
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in... | |||
TMPH-03764 |
YAP1 Protein, Human, Recombinant (His)
YAP1-2gamma,YAP2L,YAP65 |
Human | P. pastoris (Yeast) |
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1,... | |||
TMPY-00150 |
IGF2/IGF-II Protein, Human, Recombinant
PP9974,胰岛素样生长因子,C11orf43,IGF-II,insulin-like growth factor 2 |
Human | P. pastoris (Yeast) |
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumor, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. IGF-2/IGF-II is a mediator of prolactin-induced alveologenesis; prolactin, IGF-2, and cyclin D1, all of which are overexpressed in br... | |||
TMPH-00727 |
FliA Protein, E. coli, Recombinant (His)
RNA polymerase sigma factor for flagellar operon,Sigma-28,Si... |
E. coli | E. coli |
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes. | |||
TMPH-00728 |
FliA Protein, E. coli, Recombinant
fliA,Sigma-27,Sigma F,Sigma-28,RNA polymerase sigma factor f... |
E. coli | E. coli |
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes. FliA Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 27.7 kDa and the accession number is P0AEM6. | |||
TMPH-00731 |
RpoS Protein, E. coli, Recombinant
RNA polymerase sigma factor RpoS,rpoS,Sigma S,Sigma-38 |
E. coli | E. coli |
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.; Protects stationary phase cells from killing induced by endoribonuclease MazF. | |||
TMPK-00672 |
CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His)
CTGRP,CTGF,IBP-8,CCN2,NOV2,HCS24,IGFBP8,Fisp12 |
Rhesus | HEK293 Cells |
Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis.CTGF can simultaneously interact with several factors with its four domains. The microenvironment differs depending on the types of cells and tissues and differentiation stages of these cells. CTGF/CCN2 Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His ta... | |||
TMPH-00730 |
RpoS Protein, E. coli, Recombinant (His)
Sigma S,rpoS,RNA polymerase sigma factor RpoS,Sigma-38 |
E. coli | E. coli |
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. Controls, positively or negatively, the expression of several hundred genes, which are mainly involved in metabolism, transport, regulation and stress management.; Protects stationary phase cells from killing induced by endoribonuclease MazF. | |||
TMPJ-00464 |
APE Protein, Human, Recombinant
APEX,Apurinic-Apyrimidinic Endonuclease 1,APEN,DNA-(Apurinic... |
Human | E. coli |
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down... | |||
TMPH-00077 |
IAA17 Protein, Arabidopsis thaliana, Recombinant (His & Myc)
IAA17,Auxin response 3,Indoleacetic acid-induced protein 17,... |
Arabidopsis thaliana | E. coli |
Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression. IAA17 Protein, Arabidopsis thaliana, Recombinant (His & Myc) is expressed in E.... | |||
TMPH-03079 |
Sialidase Protein, Paeniclostridium sordellii, Recombinant (His & Myc)
Neuraminidase,Sialidase |
Paeniclostridium sordellii | E. coli |
Sialidases have been suggested to be pathogenic factors in microbial infections. Sialidase Protein, Paeniclostridium sordellii, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.2 kDa and the accession number is P15698. | |||
TMPK-01000 |
CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated
CTGF,CCN2,IBP-8,IGFBP8,Fisp12,CTGRP,HCS24,MGC102839,NOV2 |
Human | HEK293 Cells |
Connective tissue growth factor (CTGF) is a member of the CCN matricellular protein family, consisting of four domains, that regulates the signaling of other growth factors and promotes kidney fibrosis.CTGF can simultaneously interact with several factors with its four domains. The microenvironment differs depending on the types of cells and tissues and differentiation stages of these cells. CTGF/CCN2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells wi... | |||
TMPH-03080 |
Sialidase Protein, Paeniclostridium sordellii, Recombinant (hFc & Myc)
Sialidase,Neuraminidase |
Paeniclostridium sordellii | HEK293 Cells |
Sialidases have been suggested to be pathogenic factors in microbial infections. Sialidase Protein, Paeniclostridium sordellii, Recombinant (hFc & Myc) is expressed in HEK293 mammalian cells with C-hFC-Myc tag. The predicted molecular weight is 70.7 kDa and the accession number is P15698. | |||
TMPH-03512 |
GT Protein, Solanum melongena, Recombinant (His & Myc)
GT,UDP-glucose flavonoid 3-O-glucosyltransferase,Anthocyanid... |
Solanum melongena | Baculovirus Insect Cells |
In the presence of other necessary color factors, this glycosylation reaction allows the accumulation of anthocyanin pigments. GT Protein, Solanum melongena, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 52.2 kDa and the accession number is Q43641. | |||
TMPJ-00080 |
IL-11 Protein, Human, Recombinant (P. pastoris)
白细胞介素,Oprelvekin,Adipogenesis Inhibitory Factor,白介素,IL11,AGI... |
Human | P. pastoris (Yeast) |
Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. It also promotes the proliferation of hepatocytes in response to liver damage. Binding to its recepto... | |||
TMPH-00729 |
RpoH Protein, E. coli, Recombinant (His & Myc)
RNA polymerase sigma-32 factor,Heat shock regulatory protein... |
E. coli | E. coli |
Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. Intracellular concentration of free RpoH protein increases in response to heat shock, which causes association with RNA polymerase (RNAP) and initiation of transcription of heat shock genes, including numerous global transcriptional regulators and genes involved in maintaining membrane... | |||
TMPH-02401 |
rplL Protein, Legionella pneumophila, Recombinant (His & Myc)
Large ribosomal subunit protein bL12,50S ribosomal protein L... |
Legionella pneumophila | E. coli |
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation. rplL Protein, Legionella pneumophila, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.4 kDa and the accession number is Q5ZYQ1. | |||
TMPH-00028 |
Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP)
Protein Rep78 |
AAV-2 | E. coli |
Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a priming site for initiation of the synthesis of a complementary strand. Plays also a role as transcriptional regulator, DNA helicase and as key factors in site-specific integration of the viral genome. Regulates host PKA activity by interacting with host PRKX as a mechanism of i... | |||
TMPH-01974 |
Prothrombin Protein, Human, Recombinant (His)
F2,Coagulation factor II,Prothrombin |
Human | P. pastoris (Yeast) |
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Prothrombin Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 67.3 kDa and the accession number is P00734. | |||
TMPH-01610 |
LINGO1 Protein, Human, Recombinant (His)
Leucine-rich repeat neuronal protein 6A,LINGO1,Leucine-rich ... |
Human | E. coli |
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. | |||
TMPH-00038 |
Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc)
Snake venom serine protease,Thrombin-like enzyme contortrixo... |
Agkistrodon contortrix | E. coli |
Thrombin-like snake venom serine protease that cleaves beta chain of fibrinogen (FGB), releasing fibrinopeptide B. Has a coagulant activity activating blood coagulation factors V (F5) and XIII (F13A1). Thrombin-like enzyme contortrixobin Protein, Agkistrodon contortrix, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 32.4 kDa and the accession number is P82981. | |||
TMPH-03162 |
Serralysin Protein, Proteus mirabilis, Recombinant (His & SUMO)
Serralysin,Extracellular metalloprotease,zapA |
Proteus mirabilis | E. coli |
One of the virulence factors produced during swarmer cell differentiation of the bacteria, which seems to be associated with pathogenesis. The protease activity is limited to IgA1, IgA2, as well as IgG degradation. Serralysin Protein, Proteus mirabilis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 68.4 kDa and the accession number is Q11137. | |||
TMPK-00929 |
FLT3 Protein, Mouse, Recombinant (hFc)
FL,FLT3LG,Flt3L,SL cytokine,Flt3 ligand |
Mouse | HEK293 Cells |
Flt‑3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. FLT3 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 84.78 kDa and the accession number is Q00342. | |||
TMPY-02949 |
AP2 Gamma/TFAP2C Protein, Human, Recombinant (His)
ERF1,hAP-2g,transcription factor AP-2 gamma (activating enha... |
Human | E. coli |
TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2C may be prognostic indicators for patients with breast tumors. TFAP2C gene has been tested fo... | |||
TMPJ-01383 |
Serpin A10 Protein, Human, Recombinant (His)
PZI,Protein Z-Dependent Protease Inhibitor,Serpin A10,ZPI,PZ... |
Human | HEK293 Cells |
Serpin A10 is a secreted protein that belongs to the serpin family. It is predominantly expressed in the liver and secreted in the plasma. Its phosphorylation sites are present in the extracelllular medium. It inhibits factors Xa and XIa of the coagulation cascade in the presence of protein Z, calcium, and phospholipid. Mutations in SERPINA10 are associated with venous thrombosis. | |||
TMPH-01285 |
EEF1D Protein, Human, Recombinant (His)
Elongation factor 1-delta,EF1D,EF-1-delta,EEF1D,Antigen NY-C... |
Human | E. coli |
EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome.; Regulates induction of heat-shock-responsive genes through association with heat shock transcription factors and direct DNA-binding at heat shock promoter elements (HSE). | |||
TMPJ-00191 |
FSTL1 Protein, Human, Recombinant
FRP,Follistatin-Related Protein 1,Follistatin-Like Protein 1... |
Human | E. coli |
Follistatin-Related Protein 1 (FSTL1) is a secreted protein that contains two EF-hand domains, one follistatin-like domain, one Kazal-like domain, and one VWFC domain. Its functional significance in physiological and pathological processes is not completely understood. However, FSTL1 is thought to modulate the action of some growth factors on cell proliferation and differentiation. FSTL1 maybe an autoantigen associated with rheumatoid arthritis. | |||
TMPJ-00720 |
TXNDC12 Protein, Human, Recombinant (His)
TLP19,ERp19,Thioredoxin Domain-Containing Protein 12,hTLP19,... |
Human | HEK293 Cells |
Thioredoxin Domain-Containing Protein 12 belongs to the thioredoxin superfamily. In this family, proteins possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors. TXNDC12 is widely expressed in many tissues and contains one thioredoxin domain. | |||
TMPK-00204 |
FGL1 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated
Hepassocin,Lag3 ligand,HP-041,LFIRE-1,HFREP1,FGL1,HFREP-1,FG... |
Human | HEK293 Cells |
Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FLG-1 is encoded by the FGL1 gene.Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII.Fibrinogen-like Protein 1 is a major immune inhibitory ligand of LAG-3. | |||
TMPK-00125 |
FLT3 Ligand Protein, Human, Recombinant (hFc)
FLT3LG,FL,Flt3 ligand,SL cytokine,Flt3L |
Human | HEK293 Cells |
Flt‑3 Ligand, also known as FL, is an alpha -helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages.Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. FLT3 Ligand Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 44.8 kDa and the accession number is P49771-1. | |||
TMPK-01153 |
PLVAP Protein, Human, Recombinant (His)
PV1,FELS |
Human | HEK293 Cells |
Plasmalemma vesicle-associated protein (PLVAP, also called PV-1) is the only protein that forms endothelial diaphragms. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such as high glucose and vascular endothelial growth factor (VEGF) induce its expression, leading to the exacerbation of cellular permeability. Because the new blood vessels are fragile and leaky, PLVAP could possibly be considered a therapeutic target against retinovascular diseases... | |||
TMPH-02753 |
LINGO1 Protein, Mouse, Recombinant (His)
Leucine-rich repeat neuronal protein 6A,Leucine-rich repeat ... |
Mouse | E. coli |
Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. LINGO1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The pre... | |||
TMPJ-00123 |
FLT3LG Protein, Mouse, Recombinant (His)
Fms-related tyrosine kinase 3 ligand (Flt3L),Flt3 ligand,SL ... |
Mouse | HEK293 Cells |
Fms-related tyrosine kinase 3 ligand(Flt3L) is a single-pass type I membrane protein and consists of 232 amino acids. Flt3L is a hematopoietic four helical bundle cytokine, structurally homologous to stem cell factor and colony stimulating factor. Flt3L synergizes well with a number of other colony stimulating factors and interleukins. Flt3L stimulates the proliferation and differentiation of various blood cell progentiors by activating FLT3. | |||
TMPH-02865 |
Wnt3 Protein, Mouse, Recombinant (His & SUMO)
Proto-oncogene Int-4,Proto-oncogene Wnt-3,Wnt3 |
Mouse | E. coli |
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development. | |||
TMPK-00710 |
Claudin-4 Protein-VLP, Human, Recombinant
Claudin4,CLDN4,Claudin-4,CPETR1,CPE-R,WBSCR8,CPE R |
Human | HEK293 Cells |
Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs in... | |||
TMPY-05749 |
SARS-CoV-2 NSP8 Protein (Avi)
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SARS-CoV-2 | E. coli |
NSP8 is a nonstructural protein of coronavirus. NSP8 acts as a primase in RNA synthesis. NSP8 and NSP7 are essential co-factors of NSP12 (the catalytic subunit with RNA-dependent RNA polymerase activity) that can remarkably stimulate RdRp activity. The nsp12-nsp7-nsp8 subcomplex is defined as the minimal core component for mediating coronavirus RNA synthesis. SARS-CoV-2 NSP8 Protein (Avi) is expressed in E. coli expression system. The predicted molecular weight is 24.17 kDa and the accession num... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMID-0061 |
MK7-d7
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MK7-d7 是 MK7 的氘代化合物。MK7 的 CAS 号为 2124-57-4。Menaquinone-7 是一种最早作为抗出血因子被发现的维生素K2家族成员。它是Gla-蛋白羧化反应中最具生物活性的辅因子,补充它也是激活Gla基质蛋白并干预钙化性主动脉瓣狭窄(CAVS)进展的一种药理选择。 |