购物车
- 全部删除
- 您的购物车当前为空
Daprodustat 是一种口服具有活力的缺氧诱导因子脯氨酰羟化酶 (HIFPH) 抑制剂,可用于与慢性肾病相关的贫血病的研究。
为众多的药物研发团队赋能,
让新药发现更简单!
Daprodustat 是一种口服具有活力的缺氧诱导因子脯氨酰羟化酶 (HIFPH) 抑制剂,可用于与慢性肾病相关的贫血病的研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 419 | 现货 | |
5 mg | ¥ 755 | 现货 | |
10 mg | ¥ 1,250 | 现货 | |
25 mg | ¥ 2,060 | 现货 | |
50 mg | ¥ 3,455 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 660 | 现货 |
产品描述 | Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor. |
体外活性 | GSK1278863有效诱导EPO反应,并刺激非EPO机制以促进红细胞生成。[1] |
激酶实验 | SK Assay: A medium-throughput assay suitable for screening for inhibitors of recombinant human SK has been established. Briefly, 5 μg of purified GST-SK fusion protein are combined with 12 nM sphingosine, which contains a 100-fold dilution of [3-3H]sphingosine (20 Ci/mmol), 1 mM ATP, 1 mM magnesium chloride, and 200 μL of assay buffer [20 mM Tris HCl (pH 7.4), 20% glycerol, 1 mM beta-mercaptoethanol, 1 mM EDTA, 20 mM zinc chloride, 1 mM sodium orthovanadate, 15 mM sodium fluoride, and 0.5 mM 4-deoxypyridoxine]. Assays are run for 30 min at 25°C with shaking and contains either 1% DMSO or 5 g/mL test compound, which corresponds to concentrations of 10–25 μM. The reactions are terminated with 50 μL of concentrated ammonium hydroxide, followed by extraction of the assay mixture with chloroform:methanol (2:1). The aqueous portion is transferred to scintillation vials and radioactivity is quantified as a measure of [3H]]S1P formation using a Beckman LS 3801 Scintillation Counter. The intra-assay coefficient of variation is ~10%, whereas interassay variation is ~20%. |
别名 | GSK1278863 |
分子量 | 393.43 |
分子式 | C19H27N3O6 |
CAS No. | 960539-70-2 |
Smiles | OC(=O)CNC(=O)C1C(=O)N(C2CCCCC2)C(=O)N(C2CCCCC2)C1=O |
密度 | 1.359 g/cm3 (Predicted) |
存储 | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | Ethanol: <1 mg/mL H2O: <1 mg/mL DMSO: 10 mg/mL (25.42 mM) | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
DMSO
|
评论内容