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Search Results for " cyclic "

Targets Recommended: STING Endogenous Metabolite

354

抑制剂 & 化合物

72

天然产物

5

化合物库

35

重组蛋白

9

同位素标记化合物

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Cat. No.	Product Name
L9610	环肽库		80 compounds
	80 种环肽分子，可用于高通量和高内涵筛选；
L9300	大环化合物库		210 compounds
	210 种活性已知的大环化合物，用于高通量、高内涵筛选；
L7860	Mini片段亲电杂环化合物库		369 compounds
	高溶解度共价杂环片段库中的 369 个化合物
L7700	神经再生化合物库		524 compounds
	524 种神经再生相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L6750	活血化瘀中药单体库		580 compounds
	580种来源于常见活血化瘀中药的单体化合物，是药物开发、药理研究等领域的有效工具。

化合物库

Cat.No: L9610

Compounds: 80

大环化合物库

Cat.No: L9300

Compounds: 210

Mini片段亲电杂环化合物库

Cat.No: L7860

Compounds: 369

神经再生化合物库

Cat.No: L7700

Compounds: 524

活血化瘀中药单体库

Cat.No: L6750

Compounds: 580

Cat. No.	Product Name	Target	Signaling Pathways
T36983	Cyclic-di-GMP disodium Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium	STING; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Cyclic-di-GMP disodium (5GP-5GP disodium) 是细菌的第二信使，也是一种 STING 激动剂，参与原核生物的多种过程，包括生物膜的形成、运动、和细胞周期的进展。Cyclic-di-GMP disodium 对癌细胞显示出抗增殖活性，可诱导 CD4 受体表达升高和细胞周期停滞。Cyclic-di-GMP disodium 可用于癌研究癌症。
TP1035L	Cyclic somatostatin Acetate Somatostatin (sheep), monoacetate (salt),Cyclic somatostatin Acetate(38916-34-6 free base),Somatostatin-14,SRIF-14,monoacetate (salt)	Others	Others
	Cyclic somatostatin Acetate(38916-34-6(free base)) (Somatostatin-14) 是一种环状十四肽，可调节许多内分泌和神经系统功能。
T12472	Pifithrin-α, p-Nitro, Cyclic PFN-α	p53	Apoptosis
	Pifithrin-α, p-Nitro, Cyclic (PFN-α) 是 p53 的细胞渗透性和活性形式抑制剂。它对暴露于 Etoposide 的皮层神经元的保护作用比 Pifithrin-α 强一个数量级，ED50为30 nM。它也作为 p53 转录后的活性抑制剂。
TP1035	Cyclic somatostatin SRIF-14,合成生长抑素,环状生长激素抑制素,Somatostatin-14	Others	Others
	Cyclic somatostatin (SRIF-14) 是生长激素释放抑制因子，可用于研究胃十二指肠溃疡出血。
TP1501L	CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)	MMP	Proteases/Proteasome
	CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base) 是基质金属蛋白酶 (MMP)-2 和 MMP-9 的抑制剂。它也被称为IV 型胶原酶或明胶酶。明胶酶是癌症治疗干预的潜在靶点，这些酶的抑制剂可以防止肿瘤进展。
T3637	Pifithrin-β hydrobromide Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)	Ferroptosis; p53	Apoptosis
	Pifithrin-β hydrobromide (Cyclic PFT-α) 是一种 p53 的抑制剂，可逆地阻断 p53 依赖性转录激活和细胞凋亡。IC50值为23 μM。
T37475	Cyclic ADP-Ribose (ammonium salt) cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt)	Others	Others
	Cyclic ADP-ribose (cADP-ribose) is an endogenous metabolite of NAD+ that mobilizes the release of stored Ca2+ in the endoplasmic reticulum via ryanodine receptors in various cell types.[1],[2],[3],[4],[5] This second messenger is generated via the cADP-ribose synthases CD38 and CD157.[6],[5],[7] cADP-Ribose may also trigger the cell surface Ca2+ influx channel TRPM2 in a temperature-dependent manner.[8] In vitro, cADP-ribose modulates Ca2+ signaling in rat and mouse cardiomyocytes treated with i...
T33516	Msh (5-10), cyclic Cyclic H-asp-his-phe-arg-trp-lys-NH2	Others	Others
	Msh (5-10), cyclic, as a synthetic peptide, can conjugate with fatty acids for enhanced potency.
TP1620	Cyclic MKEY
	MKEY, a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, has been shown to protect against atherosclerosis and aortic aneurysm formation by mediating inflammation, but whether it modulates neuroinflammation and brain injury has not
TP1501	CTTHWGFTLC, CYCLIC
	This cyclic CTT Gelatinase Inhibitor peptide is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, and inhibitors of t
T36985	Cyclic di-UMP (sodium salt)	Others	Others
	Cyclic di-UMP is a pyrimidine-containing cyclic dinucleotide (CDN).1It is produced by bacterial cGAS/DncV-like nucleotidyltransferases (CD-NTases), such as LpCdnE02 fromL. pneumophila, and binds to cGAS, in the apo or dsDNA-bound forms, with reduced affinity compared to 2'3'-cGAMP or 3'3'-cGAMP .1,2Cyclic di-UMP is intended for use as a negative control for cyclic di-GMP signaling. 1.Whiteley, A.T., Eaglesham, J.B., de Oliveira Mann, C.C., et al.Bacterial cGAS-like enzymes synthesize diverse nuc...
T36984	Cyclic di-IMP (sodium salt)	Others	Others
	Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) p...
T35424	8-bromo-Cyclic AMP	Others	Others
	8-bromo-Cyclic AMP is a brominated derivative of cAMP that remains long-acting due to its resistance to degradation by cAMP phosphodiesterase. It can activate cAMP-dependent protein kinase, inhibiting growth, decreasing proliferation, increasing differentiation, and inducing apoptosis of cancer cells.
T35595	Cyclic di-AMP (sodium salt)	Others	Others
	Cyclic di-AMP (c-di-AMP) is a second messenger produced by bacteria but not by mammals. Generated by a family of diadenylate cyclases, c-di-AMP can impact bacterial cell growth, cell wall homeostasis, pathogenicity, and other cellular functions. Bacteria-derived cyclic dinucleotides, including c-di-AMP, trigger the expression of interferon genes in mammalian cells.
T64318	Capecitabine-2',3'-cyclic Carbonate	Others	Others
	Capecitabine-2',3'-cyclic Carbonate 是一种抗增殖化合物。
T37803	8-bromo-Cyclic ADP-Ribose (sodium salt)	Others	Others
	Cyclic ADP-ribose (cADP-ribose) is a calcium mobilizing nucleotide that is biosynthesized from NAD+ by cADP-ribose synthases, including CD38. cADP-Ribose appears to activate calcium channels in intracellular membranes, which in turn activate ryanodine receptors. 8-bromo-cADP-Ribose is a stable, cell-permeable analog that blocks calcium release evoked by cADP-ribose in sea urchin egg homogenates with an IC50 value of 1.7 μM. It is commonly used to investigate intracellular signaling through cADP-...
T21697	Sp-Cyclic AMPS (sodium salt)	Others	Others
	Sp-cAMPS sodium salt 作为 cAMP 类似物，是一种依赖 cAMP 的PKA I 和PKA II 的有效激活剂。Sp-cAMPS sodium salt 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 μM。Sp-cAMPS sodium salt 结合PDE10 GAF 结构域，EC50为 40 μM 。
T36677	Rp-8-bromo-Cyclic AMPS (sodium salt)	Others	Others
	Rp-8-bromo-Cyclic AMPS (Rp-8-bromo-cAMPS) is a cell-permeable cAMP analog that combines an exocyclic sulfur substitution in the equatorial position of the cyclophosphate ring with a bromine substitution in the adenine base of cAMP. It acts as an antagonist of cAMP-dependent protein kinases (PKAs) and is resistant to hydrolysis by cyclic nucleotide phosphodiesterases. Rp-8-bromo-cAMPS more effectively antagonizes cAMP-dependent activation of purified PKA type I from rabbit muscle than PKA type II...
T60419	Cyclic HPMPC	Others	Others
	Cyclic HPMPC 是有效的抗病毒剂，可以增加感染致死性牛痘苗病毒 (IHD 株) 小鼠的动脉氧饱和度水平。用 Cyclic HPMPC 治疗可改善先天性豚鼠巨细胞病毒 (GPCMV) 感染的结果并减少豚鼠模型中的病毒复制。
T21705	8-CPT-Cyclic AMP (sodium salt)	Others	Others
	8-CPT-Cyclic AMP (8-CPT-cAMP) sodium 是环 AMP 依赖性蛋白激酶的选择性激活剂。 8-CPT-Cyclic AMP sodium 也是有效的环 GMP 特异性磷酸二酯酶(PDE VA)抑制剂，IC50为 0.9 μM。 8-CPT-Cyclic AMP sodium 还抑制 PDE III 和 PDE IV，IC50分别为 24 和 25 μM。8-CPT-Cyclic AMP sodium 对 Epac 具有非常高的亲和力，是一种有效的Epac 活化剂。
T73362	C-di-IMP Cyclic-di-IMP	Others	Others
	C-di-IMP (Cyclic-di-IMP) 是一种STING 激动剂。C-di-IMP 可用于肿瘤的研究。
T10642	c-di-AMP 环二腺苷酸,Cyclic diadenylate,Cyclic-di-AMP	Others	Others
	c-di-AMP (Cyclic diadenylate) is a STING agonist. It binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway.
T78011	Cyclic MKEY TFA
	Cyclic MKEY TFA为CXCL4-CCL5异二聚体的合成环肽抑制剂，可通过调控炎症反应预防动脉粥样硬化和主动脉瘤。此外，该化合物亦能阻止小鼠中风后脑损伤的发生。
T76544	Cyclic SSTR agonist octreotide
	Cyclic SSTR agonist octreotide 是一种 Octreotide ，可作为生长抑素受体 (SSTR) 的激动剂。
T76017	CTTHWGFTLC, CYCLIC TFA
	CTTHWGFTLC, CYCLIC TFA 是一种基质金属蛋白酶 MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为 8 μM。
T82645	Cyclic PSAP peptide
	Cyclic PSAP peptide（DWLPK）是一种环五肽，具有活性分子特性，在体内能够抑制肿瘤转移扩散和发展。
T83402	2′,3′-cGMP triethylamine Guanosine 2',3'-cyclic phosphate triethylamine	Others	Others
	2',3'-cGMP triethylamine（Guanosine 2',3'-cyclic phosphate triethylamine）是一种活性化合物，常被用于多种科学研究领域。
T82760	C-di-IMP disodium Cyclic-di-IMP disodium	STING	Immunology/Inflammation
	C-di-IMP二钠是一种效果显著的STING激动剂，主要在肿瘤领域的研究中应用。
T13606	cGAMP 3',3'-cGAMP,Cyclic GMP-AMP	Others	Others
	cGAMP is an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. It also is a STING ligand.
T9213	G140	cGAS	Immunology/Inflammation
	G140 是选择性环状GMP-AMP 合酶抑制剂，具有抗炎活性，对 h-cGAS 和 m-cGAS 的IC50值分别为 14.0 和 442 nM。
T10065	2',3'-cGAMP 2'-3'-cyclic GMP-AMP	STING; cGAS	Immunology/Inflammation
	2',3'-cGAMP (2'-3'-cyclic GMP-AMP) 是细胞天然免疫中第二信使，在DNA结合条件下由 cGAMP 合成酶 (cGAS) 催化形成。2',3'-cGAMP 可与 STING 结合形成二聚体，诱导干扰素-β（IFN-β）及其他细胞因子的产生和表达。
T12432	PF-06928215	cGAS	Immunology/Inflammation
	PF-06928215 是高亲和力 cGAS 抑制剂，IC50为 4.9 μΜ，亲和力 Kd 值为 0.2 μΜ。
T5486	RU.521 RU320521	DNA; cGAS	DNA Damage/DNA Repair; Immunology/Inflammation
	RU.521 (RU3205217) 是选择性的环状 GMP-AMP 合成酶 (cGAS) 抑制剂，抑制 cGAS 介导的干扰素上调。它也抑制dsDNA 激活受体的活性，IC50为 700 nM。它可降低来自 Aicardi-Goutières 综合征小鼠模型的巨噬细胞中干扰素的组成型表达。
T11673	IRAK4-IN-4	IRAK; cGAS	Immunology/Inflammation; NF-κB
	IRAK4-IN-4 （化合物 15）是白介素-1 受体相关激酶抑制剂，IC50为 2.8 nM。它还抑制环 GMP-AM 合酶，IC50为 2.1 nM。
T11344	G150	DNA; cGAS	DNA Damage/DNA Repair; Immunology/Inflammation
	G150 是高选择性h-cGAS 抑制剂，IC50值为 10.2 nM，用于抑制 dsDNA 引发的干扰素表达。
T83671	CCP-biotin Peptide (non-cyclized) Citrullinated Filaggrin (Q447H, S449C, G459R, E460G, S462C) (R455) (447-467)-biotin Peptide (non-cyclized),Cyclic Citrullinated Peptide-biotin Peptide (non-cyclized)
	CCP-biotin Peptide（非环化）是一种生物素化且非环化的圆形瓜氨酸化肽（CCP）版本。该序列对应于人类filaggrin的447-467氨基酸，但包含Q447H、S449C、G459R、E460G和S462C的替换，并在455位的精氨酸处发生了瓜氨酸化。CCP-biotin Peptide（非环化）旨在用于检测可能与线性肽结合的抗瓜氨酸自身抗体。
T7511	Cyclo(his-pro)	NF-κB; Endogenous Metabolite	Metabolism; NF-κB
	Cyclo(his-pro) 是一种口服具有活力的，结构上与促甲状腺激素释放激素相关的环状二肽。它能够抑制NF-κB 核积累，也能够穿越脑血屏障并影响多种炎症和应激反应。
T2923	Apremilast 阿普斯特,CC-10004,阿普司特	Apoptosis; TNF; PDE	Apoptosis; Metabolism
	Apremilast (CC-10004) 是一种口服有效的磷酸二酯酶 4 抑制剂，IC50为 74 nM。它抑制脂多糖释放TNF-α，IC50为 104 nM。
T2535	Ivabradine hydrochloride 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Ivabradine hydrochloride (S 16257-2) 是一种可口服的，超极化激活的环核苷酸门控离子通道通道阻滞剂。
T36678	Rp-8-CPT-cAMPS sodium	Others	Others
	Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP and Rp-cyclic AMPS .[1] It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II.2 By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.[2],[3]
T2137	Ibudilast AV-411,KC-404,MN-166,异丁司特	PDE	Metabolism
	Ibudilast (MN-166) 是一种环腺苷酸磷酸二酯酶 (PDE) 抑制剂，具有抗血小板聚集作用。它能够抑制气管平滑肌收缩性，可用于研究哮喘。它可对抗活化小胶质细胞的神经毒性，可能是一种有效的神经保护和抗痴呆药物。
T35421	2'-O-Succinyl-cAMP	Others	Others
	2'-O-Monosuccinyladenosine-3',5'-cyclic monophosphate is an immunogenic derivative of cAMP that has been used to generate anti-cAMP antisera and antibodies.1,2
T9137	SN-011 [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901	STING	Immunology/Inflammation
	SN-011 (GUN35901) 是选择性 STING 抑制剂，可与环状二核苷酸 (CDN) 竞争 STING 二聚体的结合口袋，从而阻断 CDN 结合和 STING 激活。它用于 STING 驱动的自身免疫和炎症性疾病的研究，抑制 STING 信号传导的 IC50值为 76 nM。
T7516	ZD7288 N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐,ICI D7288	HCN Channel	Membrane transporter/Ion channel
	ZD7288 (ICI D7288) 是一种选择性超极化激活的环核苷酸门控通道阻滞剂，可抑制海马突触可塑性。
T84482	Oleoyl 3-carbacyclic Phosphatidic Acid 3-ccPA 18:1	Others	Others
	Cyclic Phosphatidic Acids (cPAs) are naturally occurring lysophosphatidic acid (LPA) analogs, characterized by a 5-membered ring formed between the sn-2 hydroxy group and the sn-3 phosphate. Carba-derivatives of cPA (ccPA) modify the sn-2 (2-ccPA) or sn-3 (3-ccPA) linkage, hindering the conversion of cPA into LPA. Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) incorporates the 18:1 fatty acid oleate at the sn-1 position on the glycerol backbone, acting as a cyclic LPA analog. This compound...
T83937	Tricyclic cytosine tC
	Tricyclic cytosine tC 是一种用于在活细胞中成像 RNA 的荧光胞嘧啶类似物。当与共聚焦成像技术结合使用时，可用于研究单细胞分辨率下的 RNA 合成、降解和运输。激发/发射最大值 (λ) = 375/505 nm；消光系数 = 4000 M-1cm-1；量子产率 = 0.2。
T84481	Palmitoleoyl 3-carbacyclic phosphatidic acid 3-carbacyclic PA	Others	Others
	Palmitoleoyl 3-carbacyclic phosphatidic acid (3ccPA 16:1) 作为一种autotaxin (ATX) 抑制剂，具有中等效力，IC50值为620 nM。该化合物适用于黑色素瘤的研究。
T36330	Terrecyclic Acid	Others	Others
	Terrecyclic acid is a sesquiterpene originally isolated from A. terreus with antibiotic and anticancer activity. It is active against S. aureus, B. subtilis, and M. roseus (MICs = 25, 50, and 25 μg/ml, respectively). Terrecyclic acid induces a heat shock response, increases levels of reactive oxygen species (ROS), and inhibits NF-κB activity and cell growth in 3T3-Y9-B12 cells. In vivo, terrecyclic acid (0.1, 1, and 10 mg/ml) reduces the number of ascitic fluid tumor cells in a mouse model of P3...
T36548	Carbocyclic Thromboxane A2	Others	Others
	Carbocyclic Thromboxane A2 可用于生命科学领域的相关研究。其产品编号为 T36548，CAS号为 74034-56-3。
T130205	Dihydroterrecyclic acid	Others	Others
	Dihydroterrecyclic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T130205。

化合物

Cyclic-di-GMP disodium

Cat.No: T36983

Synonym: Cyclic diguanylate,5GP-5GP disodium,3',5'-Cyclic diguanylic acid,Cyclic di-GMP (sodium salt),cyclic diguanylate disodium,c-di-GMP,c-di-GMP disodium

Target: STING, Endogenous Metabolite

Cyclic somatostatin Acetate

Cat.No: TP1035L

Synonym: Somatostatin (sheep), monoacetate (salt),Cyclic somatostatin Acetate(38916-34-6 free base),Somatostatin-14,SRIF-14,monoacetate (salt)

Target: Others

Pifithrin-α, p-Nitro, Cyclic

Cat.No: T12472

Synonym: PFN-α

Target: p53

Cyclic somatostatin

Cat.No: TP1035

Synonym: SRIF-14,合成生长抑素,环状生长激素抑制素,Somatostatin-14

Target: Others

CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)

Cat.No: TP1501L

Target: MMP

Pifithrin-β hydrobromide

Cat.No: T3637

Synonym: Cyclic PFT-α,PFT-β,Cyclic Pifithrin-α hydrobromide,Pifithrin-β,PFT β (hydrobromide)

Target: Ferroptosis, p53

Cyclic ADP-Ribose (ammonium salt)

Cat.No: T37475

Synonym: cADP-Ribose,cADPR,Cyclic ADP-Ribose (ammonium salt)

Target: Others

Msh (5-10), cyclic

Cat.No: T33516

Synonym: Cyclic H-asp-his-phe-arg-trp-lys-NH2

Target: Others

Cat.No: TP1620

CTTHWGFTLC, CYCLIC

Cat.No: TP1501

Cyclic di-UMP (sodium salt)

Cat.No: T36985

Target: Others

Cyclic di-IMP (sodium salt)

Cat.No: T36984

Target: Others

8-bromo-Cyclic AMP

Cat.No: T35424

Target: Others

Cyclic di-AMP (sodium salt)

Cat.No: T35595

Target: Others

Capecitabine-2',3'-cyclic Carbonate

Cat.No: T64318

Target: Others

8-bromo-Cyclic ADP-Ribose (sodium salt)

Cat.No: T37803

Target: Others

Sp-Cyclic AMPS (sodium salt)

Cat.No: T21697

Target: Others

Rp-8-bromo-Cyclic AMPS (sodium salt)

Cat.No: T36677

Target: Others

Cat.No: T60419

Target: Others

8-CPT-Cyclic AMP (sodium salt)

Cat.No: T21705

Target: Others

Cat.No: T73362

Synonym: Cyclic-di-IMP

Target: Others

Cat.No: T10642

Synonym: 环二腺苷酸,Cyclic diadenylate,Cyclic-di-AMP

Target: Others

Cyclic MKEY TFA

Cat.No: T78011

Cyclic SSTR agonist octreotide

Cat.No: T76544

CTTHWGFTLC, CYCLIC TFA

Cat.No: T76017

Cyclic PSAP peptide

Cat.No: T82645

2′,3′-cGMP triethylamine

Cat.No: T83402

Synonym: Guanosine 2',3'-cyclic phosphate triethylamine

Target: Others

C-di-IMP disodium

Cat.No: T82760

Synonym: Cyclic-di-IMP disodium

Target: STING

Cat.No: T13606

Synonym: 3',3'-cGAMP,Cyclic GMP-AMP

Target: Others

Cat.No: T9213

Target: cGAS

Cat.No: T10065

Synonym: 2'-3'-cyclic GMP-AMP

Target: STING, cGAS

Cat.No: T12432

Target: cGAS

Cat.No: T5486

Synonym: RU320521

Target: DNA, cGAS

Cat.No: T11673

Target: IRAK, cGAS

Cat.No: T11344

Target: DNA, cGAS

CCP-biotin Peptide (non-cyclized)

Cat.No: T83671

Synonym: Citrullinated Filaggrin (Q447H, S449C, G459R, E460G, S462C) (R455) (447-467)-biotin Peptide (non-cyclized),Cyclic Citrullinated Peptide-biotin Peptide (non-cyclized)

Cat.No: T7511

Target: NF-κB, Endogenous Metabolite

Cat.No: T2923

Synonym: 阿普斯特,CC-10004,阿普司特

Target: Apoptosis, TNF, PDE

Ivabradine hydrochloride

Cat.No: T2535

Synonym: 盐酸伊伐布雷定,S 16257-2,Ivabradine HCl

Target: Adrenergic Receptor

Rp-8-CPT-cAMPS sodium

Cat.No: T36678

Target: Others

Cat.No: T2137

Synonym: AV-411,KC-404,MN-166,异丁司特

Target: PDE

2'-O-Succinyl-cAMP

Cat.No: T35421

Target: Others

Cat.No: T9137

Synonym: [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-,GUN35901

Target: STING

Cat.No: T7516

Synonym: N-乙基-1,6-二氢-1,2-二甲基-6-(甲基亚氨基)-N-苯基-4-嘧啶胺盐酸盐,ICI D7288

Target: HCN Channel

Oleoyl 3-carbacyclic Phosphatidic Acid

Cat.No: T84482

Synonym: 3-ccPA 18:1

Target: Others

Tricyclic cytosine tC

Cat.No: T83937

Palmitoleoyl 3-carbacyclic phosphatidic acid

Cat.No: T84481

Synonym: 3-carbacyclic PA

Target: Others

Terrecyclic Acid

Cat.No: T36330

Target: Others

Carbocyclic Thromboxane A2

Cat.No: T36548

Target: Others

Dihydroterrecyclic acid

Cat.No: T130205

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TCO2745	Cyclic AMP Adenosine 3',5'-cyclophosphate,cAMP,腺苷环磷酸酯,环磷腺苷,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate	Others; Endogenous Metabolite	Metabolism; Others
	Cyclic AMP (cAMP)(Adenosine 3',5'-cyclophosphate) 是有丝分裂信使，可以促进 G1期到 S 期的细胞周期进程。
T5065	GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD Monosodium-GMP,cGMP sodium salt,鸟苷-3',5'-环磷酸一钠盐,Cyclic GMP	PKA	Tyrosine Kinase/Adaptors
	GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD (cGMP sodium salt) 也称为 cGMP，是一种细胞调节剂，被描述为第二信使。它的水平随着各种激素的增加而增加，包括乙酰胆碱、胰岛素和催产素。 cGMP 激活蛋白激酶 G(PKG) 并调节离子通道电导，信号传导影响多种过程，包括平滑肌松弛和增殖、光转导和能量稳态。
T10909	Cyclic-di-GMP c-di-GMP,cyclic diguanylate,5GP-5GP	Others	Others
	Cyclic-di-GMP is a STING agonist and ubiquitous second messenger, which regulates the formation, motility and virulence of biofilms in various bacterial species.
T72243	Cyclic-di-GMP diammonium 5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium	Others	Others
	Cyclic di-GMP (c-di-GMP) diammonium 是一种STING 激活剂和无处不在的第二信使，调节生物膜的形成、运动和各种细菌的毒力。
T37687	Cyclic ADP-ribose ammonium	Others	Others
	Cyclic ADP-ribose ammonium (cADPR ammonium) is a powerful calcium mobilization second messenger synthesized from NAD+ by an ADP-ribosyl cyclase. It primarily raises cytosolic calcium levels through Ryanodine receptor-mediated release from the endoplasmic reticulum, while also facilitating extracellular influx through the opening of TRPM2 channels [1][2][3].
T10065L	2',3'-cGAMP sodium 2'-3'-cyclic GMP-AMP sodium	STING; cGAS	Immunology/Inflammation
	2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) 是细胞天然免疫中第二信使，在 DNA 结合条件下由 cGAMP 合成酶 (cGAS) 催化形成。2',3'-cGAMP sodium 可与 STING 结合形成二聚体，诱导 IFN-β 及其他细胞因子的产生和表达。
T19253	Cyclic ADP-ribose cADPR	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Cyclic ADP-ribose (cADPR) is an effective calcium mobilization second messenger, which is synthesized from NAD + by ADP-ribosyl cyclase. Cyclic ADP-ribose mainly increases cytosolic calcium through Ryanodine receptor-mediated endoplasmic reticulum release
T64248	Cyclic-di-GMP sodium	Others	Others
	Cyclic di-GMP sodium (c-di-GMP sodium) 是一种 STING 激活剂，也是一种无处不在的第二信使，具有调节生物膜的形成、运动和各种细菌的毒力的作用。
T5671	Isophorone	Others	Others
	Isophorone 是一种可用作聚合物前体的 α,β-不饱和环状酮。
T4725	N-Acetyl-D-mannosamine N-乙酰-D-甘露糖胺,2-ACETAMIDO-2-DEOXY-D-MANNOPYRANOSE HYDRATE	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-D-mannosamine 是一种单糖，在糖脂和糖蛋白中发现的神经氨酸的化学或酶合成中用作前体。N-Acetyl-D-mannosamine 是合成细菌荚膜聚唾液酸(PA)必需前体n -乙酰神经氨酸的特异性底物。N-Acetyl-D-mannosamine 用于合成唾液酸。它也是许多碳水化合物衍生的生物活性化合物家族和候选药物的合成中间体。N-Acetyl-D-mannosamine 可用于研究认知障碍和衰老。
T1083	Theophylline Theo-24,1,3-Dimethylxanthine,茶碱	Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物，具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。
TN4510	(+)-Medioresinol Di-O-β-D-glucopyranoside (+)-Mediresinol Di-O-beta-D-glucopyranoside,(+)-Medioresinol Di-O-β-D-glucopyranoside	PDE	Metabolism
	(+)-Medioresinol Di-O-β-D-glucopyranoside 对环 AMP 磷酸二酯酶具有很强的抑制活性。
TN7068	Sinomenine N-oxide	Others	Others
	Sinomenine N-oxide 是青藤碱循环代谢机制的主要代谢产物之一。
T13495	3-Amino-2-piperidinone Cyclo-ornithine	Endogenous Metabolite	Metabolism
	3-Amino-2-piperidinone 是来自生物体的代谢物，可用作环状鸟氨酸类似物。
T1665	Daptomycin 达托霉素,LY146032	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Daptomycin (LY146032) 是脂肽类抗生素，在体外快速灭活革兰氏阳性细菌。
TN6444	Cyclo(Tyr-Leu)	Antifungal	Microbiology/Virology
	Cyclo(Tyr-Leu) 是一种来自马齿苋 Portulaca oleracea Linn 的环状二肽，具有细胞毒性、抗真菌和抗凝血活性。
T21518	Colistin methanesulfonate sodium salt 粘杆菌素甲基磺酸钠,Colistin Methanesulfonate (sodium salt)	Cell wall; Antibacterial	Immunology/Inflammation; Microbiology/Virology
	Colistin methanesulfonate sodium salt (Colistimethate Sodium) 是一种来自 Bacillus colistinus 的环状多肽抗生素，由多粘菌素 E1 和 E2 组成。
T1226	Bacitracin Albac,Ziba-RX,杆菌肽	Antibacterial; Antibiotic	Microbiology/Virology
	Bacitracin (Ziba-RX) 是一种用于葡萄球菌感染的多肽抗生素。它通过与焦磷酸十一癸烯基结合，起抑制细胞壁生物合成作用。
T4805	α-Pyridone 2-Hydroxypyridine,2-羟基吡啶	Others; Endogenous Metabolite	Metabolism; Others
	α-Pyridone (2-Hydroxypyridine) 是内源性代谢产物的一种。
T1441	Capreomycin sulfate Capastat sulfate,硫酸卷曲霉素	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Capreomycin sulfate (Capastat sulfate) 是一种多肽类抗生素，与其它抗生素结合用于MDR-肺结核。
T9267	Aureobasidin A	Others; Antifungal	Microbiology/Virology; Others
	Aureobasidin A 是一种环肽和抗真菌抗生素。它是肌醇磷酸神经酰胺合酶 AUR1 的抑制剂。
T4S0792	Pinoresinol 4-O-β-D-glucopyranoside (+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside	Others; Antioxidant	Others; oxidation-reduction
	(+)-pinoresinol-β-D-glucoside; (+)-pinor 是连翘中主要的活性呋喃类木脂素。它显示出抗氧化、降血压和环磷酸腺苷 (cAMP) 磷酸二酯酶抑制活性。
T1245	Colistin sulfate Colistin sulfate (1066-17-7 free base),Polymixin E Sulfate,Polymyxin E Sulfate,硫酸粘杆菌素	Cell wall; Antibacterial; Antibiotic; Autophagy	Autophagy; Immunology/Inflammation; Microbiology/Virology
	Colistin sulfate (Colistin sulfate (1066-17-7 free base)) 是抑制革兰氏阴性细菌的一种多肽抗生素，与革兰氏阴性细菌的外细胞膜中的脂多糖和磷脂结合起作用。
T3788	Rehmannioside A	Apoptosis; Others; NF-κB; MAPK	Apoptosis; MAPK; NF-κB; Others
	Rehmannioside A 是从中药地黄中提取的环烯醚萜苷,具有神经保护活性，通过抑制 NF-κB 和 MAPK 信号通路发挥作用。
T6S0627	Mesaconitine 新乌碱,新乌头碱；中乌头碱	TNF	Apoptosis
	Mesaconitine 是乌头属植物的一种主要活性成分，通过循环 AMP 和刺激中枢 β-肾上腺素能系统具有镇痛活性，还有抗炎活性。
T1679	Thiostrepton Thiactin,Bryamycin,Alaninamide,硫链丝菌素	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Thiostrepton (Alaninamide) 是一种选择性抑制FOXM1的抗生素。FOXM1会与 YAP/TEAD 复合物结合，形成YAP/TEAD/FOXM1 复合物。
T1130	Gramicidin 短杆菌肽,Gramicidinum,Gramicidine,Gramicidina	MRP; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology
	Gramicidin (Gramicidine) 是一种抗菌肽。它通过组装成膜中的通道，增加其对阳离子的渗透性。
T2723	Ketoisophorone 茶香酮,4-Oxoisophorone,2,6,6-Trimethyl-2-cyclohexene-1,4-dione	Others	Others
	Ketoisophorone (2,6,6-Trimethyl-2-cyclohexene-1,4-dione) 是工业上重要的环状内酯，是合成类胡萝卜素和调味剂的关键中间体。
T7933	D(+)-LACTIDE	Others	Others
	D(+)-LACTIDE 是丙酮的环状二聚体，用于合成各种药物和其他化合物，也可用于生物化学和生理学研究。
T0167	Vinpocetine 长春西丁,RGH-4405,长春西汀,Ethyl apovincaminate	IκB/IKK; NF-κB; Sodium Channel; PDE	Membrane transporter/Ion channel; Metabolism; NF-κB
	Vinpocetine (RGH-4405) 是一种长春花生物碱衍生物，是阻断 Na+通道的阻断剂。Vinpocetine 抑制IKK 的IC50为 17.17 μM。Vinpocetine 也是PDE 抑制剂，并通过直接靶向IKK 抑制NF-κB 依赖性炎症反应，已被广泛用于研究脑血管疾病。
TP1072	Valinomycin 缬氨霉素,NSC 122023	Apoptosis; PTEN; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Valinomycin (NSC-122023) 是钾离子选择性运输载体，是一种环状缩酚肽类抗生素。它通过影响生物膜抑制淋巴细胞的扩增，能诱导 CHO 细胞凋亡，也可诱导 PINK1 激活，促进 Parkin 在 Ser65 位点磷酸化。
T5S0733	Picroside III	Others	Others
	Picroside III 是一种环烯醚萜苷，分离自传统中药胡黄连中。Picroside III 具有修复肠粘膜损伤的潜力，可减轻小鼠肠道炎症。
T0945	Cyclosporin A 环孢素,Cyclosporine A,Ciclosporin,Cyclosporine,环孢菌素	Phosphatase; Antibiotic; Complement System	Immunology/Inflammation; Metabolism; Microbiology/Virology
	Cyclosporin A 属于天然产物，是一种真菌的活性代谢产物，一种环状多肽。Cyclosporin A 是一种能与亲环素结合的免疫抑制剂，可以抑制 calcineurin (IC50=7 nM)。
TN6900	Reptoside	Others	Others
	Reptoside 可从杜仲和 Ajuga chamaepitys （L.） Schreb 根部和地上部分中提取，是杜仲治疗骨质疏松症的活性环烯醚萜苷之一。
PDK0014	3-Methylxanthine	Endogenous Metabolite	Metabolism
	3-Methylxanthine 是一种黄嘌呤衍生物和环磷酸鸟苷（GMP）抑制剂，在豚鼠分离的气管肌肉中测得其IC50值为 920 μM。
T4814	(R)-5-Oxopyrrolidine-2-carboxylic acid D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid,D-焦谷氨酸	Others; Endogenous Metabolite	Metabolism; Others
	(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) 是内源性代谢产物的一种。
T0933	D-(+)-Glucono-1,5-lactone Gluconic acid lactone,Delta-Gluconolactone,Gluconolactone,葡萄糖酸内酯	Others; Reactive Oxygen Species; Endogenous Metabolite	Immunology/Inflammation; Metabolism; NF-κB; Others
	D-(+)-Glucono-1,5-lactone (Gluconolactone) 是聚羟基酸，可螯合金属离子，具有保湿、抗氧化特性。
T8787	Drotaverine hydrochloride	PDE	Metabolism
	Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂，也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂，可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果，但无抗胆碱能的效果。
T1009	Estrone Oestrone,雌酮,Fluoroethyl,Aquacrine	Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Estrone (Aquacrine) 是内源性雌激素的主要代表，由多种组织产生，尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。
T3929	Kaurenoic acid Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid	Others	Others
	Kaurenoic acid (kaurenoate) 是一种二萜，来源于 Sphagneticola trilobata 中，可以抑制细胞因子的产生和激活 NO–cyclic GMP–PKG–ATP- 敏感型钾通道信号通路，并抑制炎症疼痛。
TN3013	4,5-Dimethoxycanthin-6-one Methylnigakinone	P450; Antibacterial; PDE	Metabolism; Microbiology/Virology
	4,5-Dimethoxycanthin-6-one 从 Picrasma quassioides BENNET (Simaroubaceae)是一种从 Picrasma quassioides BENNET (Simaroubaceae) 中分离得到生物碱。4,5-Dimethoxycanthin-6-one 是一种有效的、非竞争性的 CYP1A2 介导的 phenacetin O-deethylation 抑制剂（IC50 ： 1.7 μM, Ki ： 2.6 μM），对环磷酸腺苷（cAMP）磷酸二酯酶有很强的抑制作用。4,5-Dimethoxycanthin-6-one 具有抗菌活性，对金黄色葡萄球菌及其耐药菌株有抑制作用。4,5-Dimethoxycanthin-6-one 对肿瘤细胞株 U937 和 HepG2 具有细胞毒性。
T16397	Ophiobolin A	Others	Others
	Ophiobolin A is a fungal metabolite and a phytotoxin and is an effective and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase (IC50: 9 μM). Ophiobolin A also has antimicrobial and anticancer activity.
T38650	Lyciumin B	Others	Others
	Lyciumin B is a cyclic peptide isolated from Lysium chinense.
T31141	Cyclotheonamide A	Others	Others
	Cyclotheonamide A is a cyclic peptide isolated from the marine sponge Theonella.
TN6447	Cyclo(Leu-Val)
	Cyclo(Leu-Val) is a cyclic dipeptide from the fermentation broth of F8712 strain.
T21098	Decamethylcyclopentasiloxane Dekamethylcyklopentasiloxan,Cyclopentasiloxane, decamethyl-
	Decamethylcyclopentasiloxane is a cyclic methylsiloxane with volatile properties.
T39649	ε-Amanitin	Others; ADC Cytotoxin	Antibody-drug Conjugate/ADC Related; Others
	ε-Amanitin is a cyclic peptide obtained from various mushroom species. It exhibits a strong affinity for RNA polymerase II and effectively inhibits its activity.
T68351	Homodestcardin	Others	Others
	Homodestcardin is a cyclic depsipeptide fungal metabolite that has been found in T. roseum and has immunosuppressant activity. It inhibits concanavalin A-induced proliferation of isolated mouse T cells.
T37876	Fengycin	Others	Others
	Fengycin is a cyclic lipopeptide used as an agricultural fungicide. Fengmycin has an anti-fungal infection effect by damaging the target’s cell membrane[1]. [1]. Sreyoshi Sur, et al. Selectivity and Mechanism of Fengycin, an Antimicrobial Lipopeptide, from Molecular Dynamics. J Phys Chem B. 2018 Mar 1;122(8):2219-2226.
T38415	Adenosine 5′-monophosphoramidate sodium	Others	Others
	Adenosine 5′-monophosphoramidate sodium is a derivative of adenosine used as an intermediate for nucleotide synthesis. It significantly influences the accumulation of cyclic AMP.
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天然产物

Cat.No: TCO2745

Synonym: Adenosine 3',5'-cyclophosphate,cAMP,腺苷环磷酸酯,环磷腺苷,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate

Target: Others, Endogenous Metabolite

GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SOD

Cat.No: T5065

Synonym: Monosodium-GMP,cGMP sodium salt,鸟苷-3',5'-环磷酸一钠盐,Cyclic GMP

Target: PKA

Cyclic-di-GMP

Cat.No: T10909

Synonym: c-di-GMP,cyclic diguanylate,5GP-5GP

Target: Others

Cyclic-di-GMP diammonium

Cat.No: T72243

Synonym: 5GP-5GP diammonium,c-di-GMP diammonium ; cyclic diguanylate diammonium ; 5GP-5GP diammonium,c-di-GMP diammonium,cyclic diguanylate diammonium

Target: Others

Cyclic ADP-ribose ammonium

Cat.No: T37687

Target: Others

2',3'-cGAMP sodium

Cat.No: T10065L

Synonym: 2'-3'-cyclic GMP-AMP sodium

Target: STING, cGAS

Cyclic ADP-ribose

Cat.No: T19253

Synonym: cADPR

Target: Calcium Channel

Cyclic-di-GMP sodium

Cat.No: T64248

Target: Others

Cat.No: T5671

Target: Others

N-Acetyl-D-mannosamine

Cat.No: T4725

Synonym: N-乙酰-D-甘露糖胺,2-ACETAMIDO-2-DEOXY-D-MANNOPYRANOSE HYDRATE

Target: Others, Endogenous Metabolite

Cat.No: T1083

Synonym: Theo-24,1,3-Dimethylxanthine,茶碱

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

(+)-Medioresinol Di-O-β-D-glucopyranoside

Cat.No: TN4510

Synonym: (+)-Mediresinol Di-O-beta-D-glucopyranoside,(+)-Medioresinol Di-O-β-D-glucopyranoside

Target: PDE

Sinomenine N-oxide

Cat.No: TN7068

Target: Others

3-Amino-2-piperidinone

Cat.No: T13495

Synonym: Cyclo-ornithine

Target: Endogenous Metabolite

Cat.No: T1665

Synonym: 达托霉素,LY146032

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Cat.No: TN6444

Target: Antifungal

Colistin methanesulfonate sodium salt

Cat.No: T21518

Synonym: 粘杆菌素甲基磺酸钠,Colistin Methanesulfonate (sodium salt)

Target: Cell wall, Antibacterial

Cat.No: T1226

Synonym: Albac,Ziba-RX,杆菌肽

Target: Antibacterial, Antibiotic

Cat.No: T4805

Synonym: 2-Hydroxypyridine,2-羟基吡啶

Target: Others, Endogenous Metabolite

Capreomycin sulfate

Cat.No: T1441

Synonym: Capastat sulfate,硫酸卷曲霉素

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T9267

Target: Others, Antifungal

Pinoresinol 4-O-β-D-glucopyranoside

Cat.No: T4S0792

Synonym: (+)-pinor,(+)-pinoresinol-β-D-glucoside; (+)-pinor,(+)-pinoresinol-β-D-glucoside

Target: Others, Antioxidant

Colistin sulfate

Cat.No: T1245

Synonym: Colistin sulfate (1066-17-7 free base),Polymixin E Sulfate,Polymyxin E Sulfate,硫酸粘杆菌素

Target: Cell wall, Antibacterial, Antibiotic, Autophagy

Rehmannioside A

Cat.No: T3788

Target: Apoptosis, Others, NF-κB, MAPK

Cat.No: T6S0627

Synonym: 新乌碱,新乌头碱；中乌头碱

Target: TNF

Cat.No: T1679

Synonym: Thiactin,Bryamycin,Alaninamide,硫链丝菌素

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Cat.No: T1130

Synonym: 短杆菌肽,Gramicidinum,Gramicidine,Gramicidina

Target: MRP, Antibacterial, Antibiotic

Cat.No: T2723

Synonym: 茶香酮,4-Oxoisophorone,2,6,6-Trimethyl-2-cyclohexene-1,4-dione

Target: Others

Cat.No: T7933

Target: Others

Cat.No: T0167

Synonym: 长春西丁,RGH-4405,长春西汀,Ethyl apovincaminate

Target: IκB/IKK, NF-κB, Sodium Channel, PDE

Cat.No: TP1072

Synonym: 缬氨霉素,NSC 122023

Target: Apoptosis, PTEN, Antibacterial, Antibiotic, Autophagy

Cat.No: T5S0733

Target: Others

Cat.No: T0945

Synonym: 环孢素,Cyclosporine A,Ciclosporin,Cyclosporine,环孢菌素

Target: Phosphatase, Antibiotic, Complement System

Cat.No: TN6900

Target: Others

3-Methylxanthine

Cat.No: PDK0014

Target: Endogenous Metabolite

(R)-5-Oxopyrrolidine-2-carboxylic acid

Cat.No: T4814

Synonym: D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid,D-焦谷氨酸

Target: Others, Endogenous Metabolite

D-(+)-Glucono-1,5-lactone

Cat.No: T0933

Synonym: Gluconic acid lactone,Delta-Gluconolactone,Gluconolactone,葡萄糖酸内酯

Target: Others, Reactive Oxygen Species, Endogenous Metabolite

Drotaverine hydrochloride

Cat.No: T8787

Target: PDE

Cat.No: T1009

Synonym: Oestrone,雌酮,Fluoroethyl,Aquacrine

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Endogenous Metabolite

Cat.No: T3929

Synonym: Kauren-19-Oic Acid,异贝壳杉烯酸,kaurenoate,kaur-16-en-18-oic acid

Target: Others

4,5-Dimethoxycanthin-6-one

Cat.No: TN3013

Synonym: Methylnigakinone

Target: P450, Antibacterial, PDE

Cat.No: T16397

Target: Others

Cat.No: T38650

Target: Others

Cyclotheonamide A

Cat.No: T31141

Target: Others

Cat.No: TN6447

Decamethylcyclopentasiloxane

Cat.No: T21098

Synonym: Dekamethylcyklopentasiloxan,Cyclopentasiloxane, decamethyl-

Cat.No: T39649

Target: Others, ADC Cytotoxin

Cat.No: T68351

Target: Others

Cat.No: T37876

Target: Others

Adenosine 5′-monophosphoramidate sodium

Cat.No: T38415

Target: Others

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02706	PDE9A Protein, Mouse, Recombinant (His) High affinity cGMP-specific 3',5'-cyclic phosphodie...	Mouse	E. coli
	PDE9A Protein, Mouse, Recombinant (His) is expressed in E. coli.
TMPJ-00190	CD38 Protein, Mouse, Recombinant (hFc) ADP-ribosyl cyclase 1,cyclic ADP-ribose hydrolase,T...	Mouse	HEK293 Cells
	CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Th...
TMPH-01467	PDE9A Protein, Human, Recombinant (His & Myc) PDE9A,High affinity cGMP-specific 3',5'-cyclic phos...	Human	E. coli
	PDE9A Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPJ-00202	CD157 Protein, Human, Recombinant (hFc) Cyclic ADP-ribose hydrolase 2,cADPr hydrolase 2,ADP...	Human	HEK293 Cells
	The cluster of differentiation (CD) system is a glycosyl phosphatidylinositol anchored membrane protein that belongs to the CD38 family.It is generally used in immunophynotyping. CD157 was discovered in a bone marrow stromal cell line where it facilitates pre-B-cell growth. CD157 is a bifunctional ectoenzyme that exhibits both ADP-ribosyl cyclase and cyclic ADP ribose hydrolase activities followed with CD38. It plays a role in rheumatoid arthritis (RA) due to its enhanced expression in RA-derive...
TMPH-02575	PDE5A Protein, Mouse, Recombinant (His & Myc) cGMP-specific 3',5'-cyclic phosphodiesterase,Pde5a,...	Mouse	E. coli
	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. PDE5A Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 26.1 kDa and the accession number is Q8CG03.
TMPH-03254	PDE1C Protein, Rat, Recombinant (His) Dual specificity calcium/calmodulin-dependent 3',5'-cycl...	Rat	E. coli
	PDE1C Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 92.6 kDa and the accession number is Q63421.
TMPH-02993	DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc) disA,c-di-AMP synthase,DNA integrity scanning protein DisA,D...	Mycobacterium paratuberculosis	E. coli
	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions.; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predict...
TMPJ-00886	ATF1 Protein, Human, Recombinant (His) Cyclic AMP-dependent transcription factor ATF-1,Act...	Human	E. coli
	Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. ATF1 binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It also binds to the ...
TMPH-01164	ATF-3 Protein, Human, Recombinant (His) ATF3,cAMP-dependent transcription factor ATF-3,Activating tr...	Human	E. coli
	ATF3 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01166	CGAS Protein, Human, Recombinant (His) Cyclic GMP-AMP synthase,cGAMP synthase,CGAS,h-cGAS,...	Human	E. coli
	CGAS Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01165	CREB1 Protein, Human, Recombinant (His) CREB-1,cAMP-responsive element-binding protein 1,Cyclic<...	Human	E. coli
	CREB1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02614	CREB5 Protein, Mouse, Recombinant (His) Creb5,Cyclic AMP-responsive element-binding protein...	Mouse	E. coli
	Binds to the cAMP response element and activates transcription.
TMPH-03274	ATF-4 Protein, Rat, Recombinant (His & Myc) cAMP-dependent transcription factor ATF-4,Activating transcr...	Rat	E. coli
	ATF-4 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 43.2 kDa and the accession number is Q9ES19.
TMPJ-00840	ANXA3 Protein, Human, Recombinant Annexin III,Placental anticoagulant protein III,35-alpha cal...	Human	E. coli
	Annexin A3（ANXA3）contains 4 annexin repeats and belongs to the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. ANXA3 is Inhibitor of phospholipase A2 and cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. ...
TMPH-00936	ANXA3 Protein, Human, Recombinant (His) Annexin-3,Annexin III,35-alpha calcimedin,Inositol 1,2-c...	Human	E. coli
	ANXA3 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02016	SLC19A1 Protein, Human, Recombinant (His & Myc) Reduced folate carrier protein,Intestinal folate carrier 1,<...	Human	E. coli
	SLC19A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-02613	ATF-5 Protein, Mouse, Recombinant (His & Myc) Transcription factor ATFx,Transcription factor-like protein ...	Mouse	E. coli
	Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcrip...
TMPY-02081	PDE2A Protein, Human, Recombinant (aa 215-900, His) phosphodiesterase 2A, cGMP-stimulated,cGSPDE,PED2A4,PDE2A1,C...	Human	Baculovirus Insect Cells
	cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac ...
TMPY-01819	PDE1B Protein, Human, Recombinant (His & GST) PDES1B,phosphodiesterase 1B, calmodulin-dependent,PDE1B1	Human	Baculovirus Insect Cells
	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Phosphodiesterase-1A (PDE1A), Phosphodiesterase-1B (PDE1B), Phosphodiesterase-4B (PDE4B), and Phosphodiesterase-4A (PDE4A) are important regulators of signal transduction in striatum due to their catalysis of cyclic AMP and cyclic GMP. PDE1B is highly expressed in the striatum. It b...
TMPY-02977	PDE1C Protein, Human, Recombinant (His & GST) hCam-3,phosphodiesterase 1C, calmodulin-dependent 70kDa,cam-...	Human	Baculovirus Insect Cells
	PDE1C belongs to the cyclic nucleotide phosphodiesterase family, PDE1 subfamily. Phosphodiesterases (PDEs) are a family of related phosphohydrolyases that selectively catalyze the hydrolysis of 3' cyclic phosphate bonds in adenosine and/or guanine 3',5' cyclic monophosphate (cAMP and/or cGMP). They regulate the cellular levels, localization and duration of action of these second messengers by controlling the rate of their degradation. PDEs are expressed ubiquitously, with each subtype having a s...
TMPH-00633	Heat-stable enterotoxin A2 Protein, E. coli, Recombinant (His & Myc & SUMO) sta2,Heat-stable enterotoxin A2	E. coli	E. coli
	Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
TMPH-00635	Heat-stable enterotoxin ST-IA/ST-P Protein, E. coli, Recombinant (GST) STh,sta1,Heat-stable enterotoxin ST-IA/ST-P,STp	E. coli	E. coli
	Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
TMPH-00732	RtcB Protein, E. coli, Recombinant (His) rtcB,3'-phosphate/5'-hydroxy nucleic acid ligase,RNA-splicin...	E. coli	P. pastoris (Yeast)
	GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends. Also acts as a DNA ligase in case of DNA damage by splicing 'dirty' DNA breaks, characterized by 3'-phosphate (or cyclic-phosphate) and 5'-hydroxy ends that cannot be sealed by classical DNA ligases.
TMPH-03715	Y-STB Protein, Yersinia enterocolitica, Recombinant (His & SUMO) Y-STB,ystB,Heat-stable enterotoxin B	Yersinia enterocolitica	E. coli
	Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Could play an important role in pathogenesis.
TMPH-01024	Calbindin Protein, Human, Recombinant (His) Vitamin D-dependent calcium-binding protein, avian-type,D-28...	Human	P. pastoris (Yeast)
	Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Calbindin Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 30.8 kDa and the accession number is P05937.
TMPH-00634	Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant Heat-stable enterotoxin ST-2	E. coli	E. coli
	Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 2.0 kDa and the accession number is P01560.
TMPH-03159	DODA Protein, Portulaca grandiflora, Recombinant (His & Myc & SUMO) DOPA 4,5-dioxygenase,DODA	Portulaca grandiflora	E. coli
	Opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. DODA Protein, Portulaca grandiflora, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 49.9 kDa and the accession number is Q7XA48.
TMPH-02498	AKR1C3 Protein, Mouse, Recombinant (His & Myc) Aldo-keto reductase family 1 member C13	Mouse	E. coli
	Catalyzes the dehydrogenation of 17-beta-hydroxysteroids. May also exhibit significant activity with a variety of cyclic and alicyclic alcohols. Uses both NAD and NADP, but the activity is much greater with NAD than with NADP. AKR1C3 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 44.5 kDa and the accession number is Q8VC28.
TMPH-00047	DODA Protein, Amanita muscaria, Recombinant (His & Myc) DOPA 4,5-dioxygenase,DODA	Amanita muscaria	E. coli
	Extradiol dioxygenase that opens up the cyclic ring of DOPA between carbons 4 and 5 thus producing an unstable seco-DOPA that rearranges non-enzymatically to betalamic acid. Can also catalyze the formation of muscaflavin (a pigment found in the hygrocybe mushrooms family and of some amanita species only) by a 2,3-extradiol cleavage of DOPA. DODA Protein, Amanita muscaria, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight...
TMPH-00147	IBV (strain KB8523) Replicase polyprotein 1ab (His) ORF1ab polyprotein,Replicase polyprotein 1ab,rep	IBV	Baculovirus Insect Cells
	The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.; NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. IBV (strain KB8523) Replicase polyprotein 1ab (His) is expressed in Baculo...
TMPJ-00971	PPIC Protein, Human, Recombinant (Trx & His) PPIase C,Peptidyl-Prolyl Cis-Trans Isomerase C,PPIC,Cyclophi...	Human	E. coli
	Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but prolines unusual structure stabilizes the cis form so...
TMPJ-01112	PRKG1 Protein, Human, Recombinant (His) PRKGR1B,PRKG1B,cGKI,cGMP-Dependent Protein Kinase 1,cGK1,cGK...	Human	HEK293 Cells
	cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one protein kinase domain. PRKG1 is mainly expressed in the lung and placenta. PRKG1 acts as a key mediator of the nitric oxide (NO)/cGMP signaling pathway. PRKG1 can phosphorylate many proteins that regulate platelet activation and adhesion, smooth muscle contraction, cardiac function,...
TMPY-03180	Ribonuclease A Protein, Human, Recombinant (His) RNS1,ribonuclease, RNase A family, 1 (pancreatic),RIB1,RAC1	Human	HEK293 Cells
	RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its binding to RNA (a poly-anion). More generally, RNase A is unusually polar or, rather, unusually lacking in hydrophobic groups, especially aliphatic ones. As an endonuclease, RNase A cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) ...
TMPY-04402	CSNK1G1 Protein, Human, Recombinant (His & GST) CK1γ1,casein kinase 1, gamma 1,casein kinase 1, γ1,CK1gamma1	Human	Baculovirus Insect Cells
	Casein kinase I isoform gamma-1, also known as CSNK1G1, is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Thecasein kinase I family of protein kinases are serine / threonine-selective enzymes that function as regulators ofsignal transductionpathways in most eukaryotic cell types. Casein has been used as a substrate since the earliest days of research on protein phosphorylation. Casein kinase activity associated with the endopla...
TMPY-01816	Pentraxin 3 Protein, Human, Recombinant (His) TNFAIP5,pentraxin 3,PTX3,TSG-14	Human	HEK293 Cells
	Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cycl...

重组蛋白

PDE9A Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02706

Species: Mouse

Expression System: E. coli

CD38 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00190

Species: Mouse

Expression System: HEK293 Cells

PDE9A Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01467

Species: Human

Expression System: E. coli

CD157 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00202

Species: Human

Expression System: HEK293 Cells

PDE5A Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02575

Species: Mouse

Expression System: E. coli

PDE1C Protein, Rat, Recombinant (His)

Cat.No: TMPH-03254

Species: Rat

Expression System: E. coli

DisA Protein, Mycobacterium paratuberculosis, Recombinant (His & Myc)

Cat.No: TMPH-02993

Species: Mycobacterium paratuberculosis

Expression System: E. coli

ATF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00886

Species: Human

Expression System: E. coli

ATF-3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01164

Species: Human

Expression System: E. coli

CGAS Protein, Human, Recombinant (His)

Cat.No: TMPH-01166

Species: Human

Expression System: E. coli

CREB1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01165

Species: Human

Expression System: E. coli

CREB5 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02614

Species: Mouse

Expression System: E. coli

ATF-4 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03274

Species: Rat

Expression System: E. coli

ANXA3 Protein, Human, Recombinant

Cat.No: TMPJ-00840

Species: Human

Expression System: E. coli

ANXA3 Protein, Human, Recombinant (His)

Cat.No: TMPH-00936

Species: Human

Expression System: E. coli

SLC19A1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02016

Species: Human

Expression System: E. coli

ATF-5 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02613

Species: Mouse

Expression System: E. coli

PDE2A Protein, Human, Recombinant (aa 215-900, His)

Cat.No: TMPY-02081

Species: Human

Expression System: Baculovirus Insect Cells

PDE1B Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-01819

Species: Human

Expression System: Baculovirus Insect Cells

PDE1C Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02977

Species: Human

Expression System: Baculovirus Insect Cells

Heat-stable enterotoxin A2 Protein, E. coli, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00633

Species: E. coli

Expression System: E. coli

Heat-stable enterotoxin ST-IA/ST-P Protein, E. coli, Recombinant (GST)

Cat.No: TMPH-00635

Species: E. coli

Expression System: E. coli

RtcB Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00732

Species: E. coli

Expression System: P. pastoris (Yeast)

Y-STB Protein, Yersinia enterocolitica, Recombinant (His & SUMO)

Cat.No: TMPH-03715

Species: Yersinia enterocolitica

Expression System: E. coli

Calbindin Protein, Human, Recombinant (His)

Cat.No: TMPH-01024

Species: Human

Expression System: P. pastoris (Yeast)

Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant

Cat.No: TMPH-00634

Species: E. coli

Expression System: E. coli

DODA Protein, Portulaca grandiflora, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03159

Species: Portulaca grandiflora

Expression System: E. coli

AKR1C3 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02498

Species: Mouse

Expression System: E. coli

DODA Protein, Amanita muscaria, Recombinant (His & Myc)

Cat.No: TMPH-00047

Species: Amanita muscaria

Expression System: E. coli

IBV (strain KB8523) Replicase polyprotein 1ab (His)

Cat.No: TMPH-00147

Species: IBV

Expression System: Baculovirus Insect Cells

PPIC Protein, Human, Recombinant (Trx & His)

Cat.No: TMPJ-00971

Species: Human

Expression System: E. coli

PRKG1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01112

Species: Human

Expression System: HEK293 Cells

Ribonuclease A Protein, Human, Recombinant (His)

Cat.No: TMPY-03180

Species: Human

Expression System: HEK293 Cells

CSNK1G1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04402

Species: Human

Expression System: Baculovirus Insect Cells

Pentraxin 3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01816

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0037	Tadalafil-d3
	Tadalafil-d3 是 Tadalafil 的氘代化合物。Tadalafil 的 CAS 号为 171596-29-5。Tadalafil 是一种PDE5抑制剂，IC50为 1.8 nM。
TMIJ-0313	Estrone-d2
	Estrone-d2 是 Estrone 的氘代化合物。Estrone 的 CAS 号为 53-16-7。Aquacrine是内源性雌激素的主要代表，由多种组织产生，尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。
TMIH-0457	Proguanil-d6 HCl
	Proguanil-d6 HCl 是 Proguanil HCl 的氘代化合物。Proguanil HCl 的 CAS 号为 637-32-1。Proguanil hydrochloride 是一种双胍类抗疟疾剂，在体内代谢形成环胍。它还是一种二氢叶酸还原酶抑制剂。
TMIJ-0255	Estrone-d4 Estriol EP Impurity B-d4
	Estrone-d4 是 Estrone 的氘代化合物。Estrone 的 CAS 号为 53-16-7。Aquacrine是内源性雌激素的主要代表，由多种组织产生，尤其是脂肪组织。它是脂肪细胞中雄烯二酮芳构化过程的结果。
TMIJ-0274	Sulindac-d3
	Sulindac-d3 是 Sulindac 的氘代化合物。Sulindac 的 CAS 号为 38194-50-2。Sulindac 是一种非甾体类抗炎剂，可抑制COX-2的活性，也可抑制 COX-2 的过表达。它是一种亚磺酰基茚衍生物前药，具有潜在的抗肿瘤活性。
TMIJ-0114	Vardenafil-d5
	Vardenafil-d5 是 Vardenafil 的氘代化合物。Vardenafil 的 CAS 号为 224785-90-4。Vardenafil 是选择性、高效的、具有口服活性的磷酸二酯酶5抑制剂，IC50=0.7 nM。它能够非竞争性地抑制环磷酸鸟苷水解，从而提高 cGMP 水平。它对 PDE1 (180 nM)，PDE6 (11 nM)，PDE2，PDE3，PDE4 (>1000 nM) 具有选择性。它可用于研究勃起功能障碍。
TMID-0209	Tadalafil-13C-d3
	Tadalafil-13C-d3 是 Tadalafil 的 13C 和氘代化合物。Tadalafil 的 CAS 号为 171596-29-5。Tadalafil 是一种PDE5抑制剂，IC50为 1.8 nM。
TMID-0233	Salbutamol-d9
	Salbutamol-d9 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂，用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。
TMIH-0512	Salbutamol-d3
	Salbutamol-d3 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂，用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。

同位素标记化合物

Cat.No: TMID-0037

Cat.No: TMIJ-0313

Proguanil-d6 HCl

Cat.No: TMIH-0457

Cat.No: TMIJ-0255

Synonym: Estriol EP Impurity B-d4

Cat.No: TMIJ-0274

Cat.No: TMIJ-0114

Tadalafil-13C-d3

Cat.No: TMID-0209

Cat.No: TMID-0233

Cat.No: TMIH-0512

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